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Found 4060 hits with Last Name = 'lawson' and Initial = 'jd'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Son of sevenless homolog 1 [564-1049]


()
BDBM609420
PNG
(US11702418, Example 6-10)
Show SMILES C[C@@H](Nc1nnc(C)c2ccc(cc12)N1CCn2nccc2C1)c1cccc(c1C)C(F)(F)F |r|
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Citation and Details

BindingDB Entry DOI: 10.7270/Q2C251J6
More data for this
Ligand-Target Pair
Son of sevenless homolog 1 [564-1049]


()
BDBM609446
PNG
(US11702418, Example 10-5)
Show SMILES C[C@@H](Nc1nnc(C)c2ccc(cc12)N1CCNCC(F)(F)C1)c1cccc(c1C)C(F)(F)F |r|
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BindingDB Entry DOI: 10.7270/Q2C251J6
More data for this
Ligand-Target Pair
Son of sevenless homolog 1 [564-1049]


()
BDBM609525
PNG
(US11702418, Example 11-4)
Show SMILES C[C@@H](Nc1nnc(C)c2ccc(cc12)N1CCN(CC1)C(=O)[C@@H]1CCOC1)c1cccc(c1C)C(F)(F)F |r|
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BindingDB Entry DOI: 10.7270/Q2C251J6
More data for this
Ligand-Target Pair
Son of sevenless homolog 1 [564-1049]


()
BDBM609526
PNG
(US11702418, Example 11-5)
Show SMILES C[C@@H](Nc1nnc(C)c2ccc(cc12)N1CCN(CC1)C(=O)[C@H]1CCOC1)c1cccc(c1C)C(F)(F)F |r|
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BindingDB Entry DOI: 10.7270/Q2C251J6
More data for this
Ligand-Target Pair
Son of sevenless homolog 1 [564-1049]


()
BDBM609451
PNG
(US11702418, Example 10-10)
Show SMILES C[C@@H](Nc1nnc(C)c2ccc(cc12)N1CCN(CC1)c1cnn(C)c1)c1cccc(c1C)C(F)(F)F |r|
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BindingDB Entry DOI: 10.7270/Q2C251J6
More data for this
Ligand-Target Pair
Son of sevenless homolog 1 [564-1049]


()
BDBM609522
PNG
((R)-(4-(1-methyl-4-((1-(2-methyl-3-(trifluoromethy...)
Show SMILES C[C@@H](Nc1nnc(C)c2ccc(cc12)N1CCN(CC1)C(=O)C1COC1)c1cccc(c1C)C(F)(F)F |r|
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BindingDB Entry DOI: 10.7270/Q2C251J6
More data for this
Ligand-Target Pair
Son of sevenless homolog 1 [564-1049]


()
BDBM609523
PNG
(US11702418, Example 11-2)
Show SMILES C[C@@H](Nc1nnc(C)c2ccc(cc12)N1CCN(CC1)C(=O)C1CCOCC1)c1cccc(c1C)C(F)(F)F |r|
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BindingDB Entry DOI: 10.7270/Q2C251J6
More data for this
Ligand-Target Pair
Son of sevenless homolog 1 [564-1049]


()
BDBM609524
PNG
(US11702418, Example 11-3)
Show SMILES C[C@@H](Nc1nnc(C)c2ccc(cc12)N1CCN(CC1)C(=O)C1(CC1)C(F)(F)F)c1cccc(c1C)C(F)(F)F |r|
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BindingDB Entry DOI: 10.7270/Q2C251J6
More data for this
Ligand-Target Pair
Son of sevenless homolog 1 [564-1049]


()
BDBM609452
PNG
(US11702418, Example 10-11)
Show SMILES C[C@@H](Nc1nnc(C)c2ccc(cc12)N1CCn2c(C)nc(C)c2C1)c1cccc(c1C)C(F)(F)F |r|
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BindingDB Entry DOI: 10.7270/Q2C251J6
More data for this
Ligand-Target Pair
Son of sevenless homolog 1 [564-1049]


()
BDBM609413
PNG
(US11702418, Example 6-3)
Show SMILES CNCc1ccccc1-c1ccc(s1)[C@@H](C)Nc1nnc(C)c2ccc(cc12)N1CCOCC1 |r|
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BindingDB Entry DOI: 10.7270/Q2C251J6
More data for this
Ligand-Target Pair
Son of sevenless homolog 1 [564-1049]


()
BDBM609450
PNG
(US11702418, Example 10-9)
Show SMILES C[C@@H](Nc1nnc(C)c2ccc(cc12)N1CCC(C)(N)CC1)c1cccc(c1C)C(F)(F)F |r|
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Citation and Details

BindingDB Entry DOI: 10.7270/Q2C251J6
More data for this
Ligand-Target Pair
Son of sevenless homolog 1 [564-1049]


()
BDBM609448
PNG
(US11702418, Example 10-7)
Show SMILES CNC1CCN(CC1)c1ccc2c(C)nnc(N[C@H](C)c3cccc(c3C)C(F)(F)F)c2c1 |r|
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BindingDB Entry DOI: 10.7270/Q2C251J6
More data for this
Ligand-Target Pair
Son of sevenless homolog 1 [564-1049]


()
BDBM609445
PNG
(US11702418, Example 10-4)
Show SMILES C[C@@H](Nc1nnc(C)c2ccc(cc12)N1CCNCC1)c1cccc(C(F)F)c1C |r|
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BindingDB Entry DOI: 10.7270/Q2C251J6
More data for this
Ligand-Target Pair
Son of sevenless homolog 1 [564-1049]


()
BDBM609449
PNG
(US11702418, Example 10-8)
Show SMILES C[C@@H](Nc1nnc(C)c2ccc(cc12)N1CCC(CC1)N(C)C)c1cccc(c1C)C(F)(F)F |r|
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BindingDB Entry DOI: 10.7270/Q2C251J6
More data for this
Ligand-Target Pair
Son of sevenless homolog 1 [564-1049]


()
BDBM609416
PNG
(US11702418, Example 6-6)
Show SMILES CNCc1c(F)cccc1-c1ccc(s1)[C@@H](C)Nc1nnc(C)c2ccc(cc12)N1CCOCC1 |r|
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Citation and Details

BindingDB Entry DOI: 10.7270/Q2C251J6
More data for this
Ligand-Target Pair
Son of sevenless homolog 1 [564-1049]


()
BDBM609411
PNG
((R)-4-methyl-N-(1-(2-methyl-3-(trifluoromethyl)phe...)
Show SMILES C[C@@H](Nc1nnc(C)c2ccc(cc12)N1CCN(C)CC1)c1cccc(c1C)C(F)(F)F |r|
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Citation and Details

BindingDB Entry DOI: 10.7270/Q2C251J6
More data for this
Ligand-Target Pair
Son of sevenless homolog 1 [564-1049]


()
BDBM50601067
PNG
(CHEMBL5208088 | US11702418, Example 6-4)
Show SMILES C[C@@H](Nc1nnc(C)c2ccc(cc12)N1CCNCC1)c1cccc(c1C)C(F)(F)F |r|
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Citation and Details

BindingDB Entry DOI: 10.7270/Q2C251J6
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Son of sevenless homolog 1 [564-1049]


()
BDBM609415
PNG
(US11702418, Example 6-5)
Show SMILES C[C@@H](Nc1nnc(C)c2ccc(cc12)N1CCOCC1)c1cc(N)cc(c1)C(F)(F)F |r|
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BindingDB Entry DOI: 10.7270/Q2C251J6
More data for this
Ligand-Target Pair
Son of sevenless homolog 1 [564-1049]


()
BDBM609387
PNG
(US11702418, Example 1-28)
Show SMILES C[C@@H](Nc1nncc2ccc(cc12)N1CCn2c(C1)nc(C)c2C)c1cccc(c1C)C(F)(F)F |r|
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Citation and Details

BindingDB Entry DOI: 10.7270/Q2C251J6
More data for this
Ligand-Target Pair
Son of sevenless homolog 1 [564-1049]


()
BDBM609528
PNG
((R)-4-methyl-7-(4-(1-methyl-1H-pyrazol-4-yl)pipera...)
Show SMILES C[C@@H](Nc1nnc(C)c2cnc(cc12)N1CCN(CC1)c1cnn(C)c1)c1cccc(c1C)C(F)(F)F |r|
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BindingDB Entry DOI: 10.7270/Q2C251J6
More data for this
Ligand-Target Pair
Son of sevenless homolog 1 [564-1049]


()
BDBM609468
PNG
(US11702418, Example 10-32)
Show SMILES C[C@@H](Nc1nnc(C)c2ccc(cc12)N1C[C@H]2CC[C@@H]1CN2C)c1cccc(c1C)C(F)(F)F |r,TLB:22:21:14.15:17.18,THB:11:14:21.20:17.18|
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Citation and Details

BindingDB Entry DOI: 10.7270/Q2C251J6
More data for this
Ligand-Target Pair
Son of sevenless homolog 1 [564-1049]


()
BDBM609472
PNG
(US11702418, Example 10-36)
Show SMILES C[C@@H](Nc1nnc(C)c2ccc(cc12)N1CCC2(CCNC2)CC1)c1cccc(c1C)C(F)(F)F |r|
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Citation and Details

BindingDB Entry DOI: 10.7270/Q2C251J6
More data for this
Ligand-Target Pair
Son of sevenless homolog 1 [564-1049]


()
BDBM50601075
PNG
(CHEMBL5202472 | US11702418, Example 6-9)
Show SMILES C[C@@H](Nc1nnc(C)c2cnc(cc12)N1CCNCC1)c1cccc(c1C)C(F)(F)F |r|
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BindingDB Entry DOI: 10.7270/Q2C251J6
More data for this
Ligand-Target Pair
Son of sevenless homolog 1 [564-1049]


()
BDBM609473
PNG
(US11702418, Example 10-37)
Show SMILES C[C@@H](Nc1nnc(C)c2ccc(cc12)N1CCC2(CCN(C)C2)CC1)c1cccc(c1C)C(F)(F)F |r|
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BindingDB Entry DOI: 10.7270/Q2C251J6
More data for this
Ligand-Target Pair
Son of sevenless homolog 1 [564-1049]


()
BDBM609540
PNG
(US11702418, Example 12-15)
Show SMILES C[C@@H](Nc1nnc(C)c2cnc(cc12)N1CCC(CC1)N(C)C)c1cccc(c1C)C(F)(F)F |r|
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BindingDB Entry DOI: 10.7270/Q2C251J6
More data for this
Ligand-Target Pair
Son of sevenless homolog 1 [564-1049]


()
BDBM609585
PNG
(US11702418, Example 12-60)
Show SMILES C[C@@H](Nc1nnc(C)c2cnc(cc12)N1C[C@H]2CC[C@@H]1CN2C)c1cccc(c1F)C(F)(F)F |r,TLB:22:21:14.15:17.18,THB:11:14:21.20:17.18|
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Citation and Details

BindingDB Entry DOI: 10.7270/Q2C251J6
More data for this
Ligand-Target Pair
Son of sevenless homolog 1 [564-1049]


()
BDBM609394
PNG
(US11702418, Example 1-37)
Show SMILES C[C@@H](Nc1nncc2ccc(cc12)N1CCn2c(C)ncc2C1)c1cccc(c1C)C(F)(F)F |r|
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Citation and Details

BindingDB Entry DOI: 10.7270/Q2C251J6
More data for this
Ligand-Target Pair
Son of sevenless homolog 1 [564-1049]


()
BDBM609618
PNG
(US11702418, Example 12-102)
Show SMILES CCN1CCN(CC1)c1cc2c(N[C@H](C)c3cccc(C(F)F)c3F)nnc(C)c2cn1 |r|
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BindingDB Entry DOI: 10.7270/Q2C251J6
More data for this
Ligand-Target Pair
Son of sevenless homolog 1 [564-1049]


()
BDBM609613
PNG
(US11702418, Example 12-89)
Show SMILES C[C@@H](Nc1nnc(C)c2cnc(cc12)N1C[C@H]2CC[C@@H]1CN2CCO)c1cccc(C#N)c1C |r,TLB:22:21:14.15:17.18,THB:11:14:21.20:17.18|
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BindingDB Entry DOI: 10.7270/Q2C251J6
More data for this
Ligand-Target Pair
Son of sevenless homolog 1 [564-1049]


()
BDBM609397
PNG
(US11702418, Example 1-40)
Show SMILES C[C@@H](Nc1nncc2ccc(cc12)N1CCn2cc(C)nc2C1)c1cccc(c1C)C(F)(F)F |r|
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Citation and Details

BindingDB Entry DOI: 10.7270/Q2C251J6
More data for this
Ligand-Target Pair
Son of sevenless homolog 1 [564-1049]


()
BDBM609457
PNG
(US11702418, Example 10-19)
Show SMILES C[C@@H](Nc1nnc(C)c2ccc(cc12)N1CCC2(CCCN2C)CC1)c1cccc(c1C)C(F)(F)F |r|
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Citation and Details

BindingDB Entry DOI: 10.7270/Q2C251J6
More data for this
Ligand-Target Pair
Son of sevenless homolog 1 [564-1049]


()
BDBM50601069
PNG
(CHEMBL5191446 | US11702418, Example 6-7)
Show SMILES C[C@@H](Nc1nnc(C)c2ccc(cc12)N1CCN(C)C(=O)C1)c1cccc(c1C)C(F)(F)F |r|
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Citation and Details

BindingDB Entry DOI: 10.7270/Q2C251J6
More data for this
Ligand-Target Pair
Son of sevenless homolog 1 [564-1049]


()
BDBM609424
PNG
(US11702418, Example 6-13)
Show SMILES CNCc1c(F)cccc1-c1ccc(s1)[C@@H](C)Nc1nnc(C)c2cnc(cc12)N1CCOCC1 |r|
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BindingDB Entry DOI: 10.7270/Q2C251J6
More data for this
Ligand-Target Pair
Son of sevenless homolog 1 [564-1049]


()
BDBM609558
PNG
(US11702418, Example 12-33)
Show SMILES C[C@@H](Nc1nnc(C)c2cnc(cc12)N1CCC(CC1)N1CCC1)c1cccc(c1C)C(F)(F)F |r|
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Citation and Details

BindingDB Entry DOI: 10.7270/Q2C251J6
More data for this
Ligand-Target Pair
Son of sevenless homolog 1 [564-1049]


()
BDBM609478
PNG
(US11702418, Example 10-42)
Show SMILES C[C@@H](Nc1nnc(C)c2ccc(cc12)N1CCC(C)(CC1)N(C)C)c1cccc(c1C)C(F)(F)F |r|
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Citation and Details

BindingDB Entry DOI: 10.7270/Q2C251J6
More data for this
Ligand-Target Pair
Son of sevenless homolog 1 [564-1049]


()
BDBM609456
PNG
(US11702418, Example 10-18 | US11702418, Example 10...)
Show SMILES C[C@@H](Nc1nnc(C)c2ccc(cc12)N1CCC2(CCCN2)CC1)c1cccc(c1C)C(F)(F)F |r|
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Citation and Details

BindingDB Entry DOI: 10.7270/Q2C251J6
More data for this
Ligand-Target Pair
Son of sevenless homolog 1 [564-1049]


()
BDBM609433
PNG
(US11702418, Example 7-3)
Show SMILES C[C@@H](Nc1nnc(C)c2ccc(O[C@H]3CCNC3)cc12)c1cccc(c1C)C(F)(F)F |r|
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Citation and Details

BindingDB Entry DOI: 10.7270/Q2C251J6
More data for this
Ligand-Target Pair
Son of sevenless homolog 1 [564-1049]


()
BDBM609432
PNG
(US11702418, Example 7-2)
Show SMILES C[C@@H](Nc1nnc(C)c2ccc(OC3CCNCC3)cc12)c1cccc(c1C)C(F)(F)F |r|
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Citation and Details

BindingDB Entry DOI: 10.7270/Q2C251J6
More data for this
Ligand-Target Pair
Son of sevenless homolog 1


(Homo sapiens (Human))
BDBM50601067
PNG
(CHEMBL5208088 | US11702418, Example 6-4)
Show SMILES C[C@@H](Nc1nnc(C)c2ccc(cc12)N1CCNCC1)c1cccc(c1C)C(F)(F)F |r|
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PDB
UniChem
PDB
Article
PubMed
0.330n/an/an/an/an/an/an/an/a


TBA



Citation and Details

Article DOI: 10.1021/acs.jmedchem.2c00741
BindingDB Entry DOI: 10.7270/Q2XD15Q0
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Son of sevenless homolog 1 [564-1049]


()
BDBM609467
PNG
(US11702418, Example 10-31)
Show SMILES C[C@@H](Nc1nnc(C)c2ccc(cc12)N1C[C@@H]2CC[C@H]1CN2C)c1cccc(c1C)C(F)(F)F |r,TLB:22:21:14.15:17.18,THB:11:14:21.20:17.18|
PDB

UniProtKB/SwissProt

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PC cid
PC sid
UniChem
0.350n/an/an/an/an/an/an/an/a


TBA



Citation and Details

BindingDB Entry DOI: 10.7270/Q2C251J6
More data for this
Ligand-Target Pair
Son of sevenless homolog 1 [564-1049]


()
BDBM609591
PNG
(US11702418, Example 12-67)
Show SMILES C[C@@H](Nc1nnc(C)c2cnc(cc12)N1CCN(C)CC1)c1cccc(c1F)C(F)(F)F |r|
PDB

UniProtKB/SwissProt

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PC cid
PC sid
UniChem
0.360n/an/an/an/an/an/an/an/a


TBA



Citation and Details

BindingDB Entry DOI: 10.7270/Q2C251J6
More data for this
Ligand-Target Pair
Son of sevenless homolog 1


(Homo sapiens (Human))
BDBM50601075
PNG
(CHEMBL5202472 | US11702418, Example 6-9)
Show SMILES C[C@@H](Nc1nnc(C)c2cnc(cc12)N1CCNCC1)c1cccc(c1C)C(F)(F)F |r|
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
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UniChem
Article
PubMed
0.360n/an/an/an/an/an/an/an/a


TBA



Citation and Details

Article DOI: 10.1021/acs.jmedchem.2c00741
BindingDB Entry DOI: 10.7270/Q2XD15Q0
More data for this
Ligand-Target Pair
Son of sevenless homolog 1 [564-1049]


()
BDBM609592
PNG
(US11702418, Example 12-68)
Show SMILES CCN1CCN(CC1)c1cc2c(N[C@H](C)c3cccc(c3F)C(F)(F)F)nnc(C)c2cn1 |r|
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UniChem
0.370n/an/an/an/an/an/an/an/a


TBA



Citation and Details

BindingDB Entry DOI: 10.7270/Q2C251J6
More data for this
Ligand-Target Pair
Son of sevenless homolog 1 [564-1049]


()
BDBM609465
PNG
(US11702418, Example 10-29)
Show SMILES C[C@@H](Nc1nnc(C)c2ccc(cc12)N1CC2CCC(C1)N2C)c1cccc(c1C)C(F)(F)F |r,TLB:11:14:21:17.18|
PDB

UniProtKB/SwissProt

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UniChem
0.390n/an/an/an/an/an/an/an/a


TBA



Citation and Details

BindingDB Entry DOI: 10.7270/Q2C251J6
More data for this
Ligand-Target Pair
Son of sevenless homolog 1 [564-1049]


()
BDBM609506
PNG
(US11702418, Example 10-71)
Show SMILES C[C@@H](Nc1nnc(C)c2ccc(cc12)N1C[C@H]2CC[C@@H]1CN2C)c1cccc(C#N)c1C |r,TLB:22:21:14.15:17.18,THB:11:14:21.20:17.18|
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UniProtKB/SwissProt

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UniChem
0.390n/an/an/an/an/an/an/an/a


TBA



Citation and Details

BindingDB Entry DOI: 10.7270/Q2C251J6
More data for this
Ligand-Target Pair
Son of sevenless homolog 1 [564-1049]


()
BDBM609431
PNG
(4-methyl-N—((R)-1-(5-(2-((methylamino)methyl(...)
Show SMILES CNCc1ccccc1-c1ccc(s1)[C@@H](C)Nc1nnc(C)c2ccc(O[C@H]3CCOC3)cc12 |r|
PDB

UniProtKB/SwissProt

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UniChem
0.400n/an/an/an/an/an/an/an/a


TBA



Citation and Details

BindingDB Entry DOI: 10.7270/Q2C251J6
More data for this
Ligand-Target Pair
Son of sevenless homolog 1 [564-1049]


()
BDBM609453
PNG
(US11702418, Example 10-12)
Show SMILES C[C@@H](Nc1nnc(C)c2ccc(cc12)N1CCN2[C@H](CCC2=O)C1)c1cccc(c1C)C(F)(F)F |r|
PDB

UniProtKB/SwissProt

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PC sid
UniChem
0.400n/an/an/an/an/an/an/an/a


TBA



Citation and Details

BindingDB Entry DOI: 10.7270/Q2C251J6
More data for this
Ligand-Target Pair
Son of sevenless homolog 1 [564-1049]


()
BDBM609532
PNG
(US11702418, Example 12-7)
Show SMILES C[C@@H](Nc1nnc(C)c2cnc(cc12)N1CCC(C)(O)CC1)c1cccc(c1C)C(F)(F)F |r|
PDB

UniProtKB/SwissProt

GoogleScholar
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PC cid
PC sid
UniChem
0.400n/an/an/an/an/an/an/an/a


TBA



Citation and Details

BindingDB Entry DOI: 10.7270/Q2C251J6
More data for this
Ligand-Target Pair
Son of sevenless homolog 1 [564-1049]


()
BDBM609683
PNG
(US11702418, Example 20-5)
Show SMILES C[C@H](Nc1nnc(C)c2cnc(cc12)N1CC2CC(C1)O2)c1cccc(c1F)C(F)(F)C(C)(C)O |r,THB:11:14:20:17|
PDB

UniProtKB/SwissProt

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UniChem
0.400n/an/an/an/an/an/an/an/a


TBA



Citation and Details

BindingDB Entry DOI: 10.7270/Q2C251J6
More data for this
Ligand-Target Pair
Son of sevenless homolog 1 [564-1049]


()
BDBM609466
PNG
(US11702418, Example 10-30)
Show SMILES C[C@@H](Nc1nnc(C)c2ccc(cc12)N1CCC(CC1)N1CCC1)c1cccc(c1C)C(F)(F)F |r|
PDB

UniProtKB/SwissProt

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UniChem
0.410n/an/an/an/an/an/an/an/a


TBA



Citation and Details

BindingDB Entry DOI: 10.7270/Q2C251J6
More data for this
Ligand-Target Pair
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