Found 282 hits with Last Name = 'lazar' and Initial = 'j' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Protein kinase C delta type
(Homo sapiens (Human)) | BDBM92596
(Sapintoxin D)Show SMILES CCCC(=O)O[C@@]12C(C3CC(=O)C[C@@]4(O)C(C=C(C)C4=O)[C@]3(O)[C@@H](C)[C@H]1OC(=O)c1ccccc1NC)C2(C)C |r,t:16| Show InChI InChI=1S/C31H39NO8/c1-7-10-23(34)40-31-24(28(31,4)5)20-14-18(33)15-29(37)22(13-16(2)25(29)35)30(20,38)17(3)26(31)39-27(36)19-11-8-9-12-21(19)32-6/h8-9,11-13,17,20,22,24,26,32,37-38H,7,10,14-15H2,1-6H3/t17-,20?,22?,24?,26+,29+,30-,31-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| 0.140 | -54.9 | n/a | n/a | n/a | n/a | n/a | 7.4 | 18 |
National Institutes of Health
| Assay Description [3H]PDBu binding to the C1 domains of MRCK alpha/beta and PKC alpha/delta was measured using the polyethylene glycol precipitation assay. |
J Biol Chem 283: 10543-9 (2008)
Article DOI: 10.1074/jbc.M707463200 BindingDB Entry DOI: 10.7270/Q2CF9NQ6 |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50385670
(CHEMBL2042399)Show SMILES C[C@H](C(=O)NCc1ccc(cc1)C(C)(C)C)c1ccc(NS(C)(=O)=O)c(F)c1 |r| Show InChI InChI=1S/C21H27FN2O3S/c1-14(16-8-11-19(18(22)12-16)24-28(5,26)27)20(25)23-13-15-6-9-17(10-7-15)21(2,3)4/h6-12,14,24H,13H2,1-5H3,(H,23,25)/t14-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 0.490 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Seoul National University
Curated by ChEMBL
| Assay Description Antagonist activity at human TRPV1 receptor expressed in CHO cells assessed as decrease in capsaicin-induced intracellular 45Ca2+ uptake after 1 hr b... |
Bioorg Med Chem 20: 215-24 (2011)
Article DOI: 10.1016/j.bmc.2011.11.008 BindingDB Entry DOI: 10.7270/Q2MG7QJJ |
More data for this Ligand-Target Pair | |
Protein kinase C delta type
(Homo sapiens (Human)) | BDBM50107112
((Z) 2,2-Dimethyl-propionic acid 2-hydroxymethyl-4-...)Show SMILES CC(C)CC(C\C=C1\CC(CO)(COC(=O)C(C)(C)C)OC1=O)CC(C)C Show InChI InChI=1S/C22H38O5/c1-15(2)10-17(11-16(3)4)8-9-18-12-22(13-23,27-19(18)24)14-26-20(25)21(5,6)7/h9,15-17,23H,8,10-14H2,1-7H3/b18-9- | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 1.16 | -49.8 | n/a | n/a | n/a | n/a | n/a | 7.4 | 18 |
National Institutes of Health
| Assay Description [3H]PDBu binding to the C1 domains of MRCK alpha/beta and PKC alpha/delta was measured using the polyethylene glycol precipitation assay. |
J Biol Chem 283: 10543-9 (2008)
Article DOI: 10.1074/jbc.M707463200 BindingDB Entry DOI: 10.7270/Q2CF9NQ6 |
More data for this Ligand-Target Pair | |
Protein kinase C delta type
(Homo sapiens (Human)) | BDBM92595
(DAG-lactone (130C045))Show SMILES CN(C)c1ccc(\C=C2\CC(CO)(COC(=O)c3ccc(cc3)N(=O)=O)OC2=O)cc1 Show InChI InChI=1S/C22H22N2O7/c1-23(2)18-7-3-15(4-8-18)11-17-12-22(13-25,31-21(17)27)14-30-20(26)16-5-9-19(10-6-16)24(28)29/h3-11,25H,12-14H2,1-2H3/b17-11- | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| KEGG PC cid PC sid UniChem
Similars
| Article PubMed
| 1.54 | -49.1 | n/a | n/a | n/a | n/a | n/a | 7.4 | 18 |
National Institutes of Health
| Assay Description [3H]PDBu binding to the C1 domains of MRCK alpha/beta and PKC alpha/delta was measured using the polyethylene glycol precipitation assay. |
J Biol Chem 283: 10543-9 (2008)
Article DOI: 10.1074/jbc.M707463200 BindingDB Entry DOI: 10.7270/Q2CF9NQ6 |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM20330
(3-[(4-tert-butylphenyl)methyl]-1-[(4-methanesulfon...)Show SMILES COc1cc(CNC(=S)NCc2ccc(cc2)C(C)(C)C)ccc1NS(C)(=O)=O Show InChI InChI=1S/C21H29N3O3S2/c1-21(2,3)17-9-6-15(7-10-17)13-22-20(28)23-14-16-8-11-18(19(12-16)27-4)24-29(5,25)26/h6-12,24H,13-14H2,1-5H3,(H2,22,23,28) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 3.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Seoul National University
Curated by ChEMBL
| Assay Description Antagonist activity towards rat TRPV1 expressed in CHO cells |
Bioorg Med Chem Lett 15: 4143-50 (2005)
Article DOI: 10.1016/j.bmcl.2005.06.006 BindingDB Entry DOI: 10.7270/Q2JH3KQB |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM50385670
(CHEMBL2042399)Show SMILES C[C@H](C(=O)NCc1ccc(cc1)C(C)(C)C)c1ccc(NS(C)(=O)=O)c(F)c1 |r| Show InChI InChI=1S/C21H27FN2O3S/c1-14(16-8-11-19(18(22)12-16)24-28(5,26)27)20(25)23-13-15-6-9-17(10-7-15)21(2,3)4/h6-12,14,24H,13H2,1-5H3,(H,23,25)/t14-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 4.16 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Seoul National University
Curated by ChEMBL
| Assay Description Antagonist activity at rat TRPV1 receptor expressed in CHO cells assessed as decrease in capsaicin-induced intracellular 45Ca2+ uptake after 1 hr by ... |
Bioorg Med Chem 20: 215-24 (2011)
Article DOI: 10.1016/j.bmc.2011.11.008 BindingDB Entry DOI: 10.7270/Q2MG7QJJ |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50385656
(CHEMBL2042264)Show SMILES CC(C(=O)NCc1ccc(cc1)C(C)(C)C)c1ccc(NS(C)(=O)=O)c(F)c1 Show InChI InChI=1S/C21H27FN2O3S/c1-14(16-8-11-19(18(22)12-16)24-28(5,26)27)20(25)23-13-15-6-9-17(10-7-15)21(2,3)4/h6-12,14,24H,13H2,1-5H3,(H,23,25) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 5.10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Seoul National University
Curated by ChEMBL
| Assay Description Antagonist activity at human TRPV1 receptor expressed in CHO cells assessed as decrease in capsaicin-induced intracellular 45Ca2+ uptake after 1 hr b... |
Bioorg Med Chem 20: 215-24 (2011)
Article DOI: 10.1016/j.bmc.2011.11.008 BindingDB Entry DOI: 10.7270/Q2MG7QJJ |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase MRCK alpha
(Homo sapiens (Human)) | BDBM92596
(Sapintoxin D)Show SMILES CCCC(=O)O[C@@]12C(C3CC(=O)C[C@@]4(O)C(C=C(C)C4=O)[C@]3(O)[C@@H](C)[C@H]1OC(=O)c1ccccc1NC)C2(C)C |r,t:16| Show InChI InChI=1S/C31H39NO8/c1-7-10-23(34)40-31-24(28(31,4)5)20-14-18(33)15-29(37)22(13-16(2)25(29)35)30(20,38)17(3)26(31)39-27(36)19-11-8-9-12-21(19)32-6/h8-9,11-13,17,20,22,24,26,32,37-38H,7,10,14-15H2,1-6H3/t17-,20?,22?,24?,26+,29+,30-,31-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| 5.90 | -45.9 | n/a | n/a | n/a | n/a | n/a | 7.4 | 18 |
National Institutes of Health
| Assay Description [3H]PDBu binding to the C1 domains of MRCK alpha/beta and PKC alpha/delta was measured using the polyethylene glycol precipitation assay. |
J Biol Chem 283: 10543-9 (2008)
Article DOI: 10.1074/jbc.M707463200 BindingDB Entry DOI: 10.7270/Q2CF9NQ6 |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM50196343
(2,2-Dimethyl-propionic acid 2-(4-tert-butyl-benzyl...)Show SMILES COc1cc(CNC(=S)NCC(COC(=O)C(C)(C)C)Cc2ccc(cc2)C(C)(C)C)ccc1O Show InChI InChI=1S/C28H40N2O4S/c1-27(2,3)22-11-8-19(9-12-22)14-21(18-34-25(32)28(4,5)6)17-30-26(35)29-16-20-10-13-23(31)24(15-20)33-7/h8-13,15,21,31H,14,16-18H2,1-7H3,(H2,29,30,35) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 6.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Seoul National University
Curated by ChEMBL
| Assay Description Displacement of [3H]RTX from rat TRPV1 expressed in CHO cells |
Bioorg Med Chem Lett 17: 214-9 (2006)
Article DOI: 10.1016/j.bmcl.2006.09.059 BindingDB Entry DOI: 10.7270/Q27D2TSX |
More data for this Ligand-Target Pair | |
Protein kinase C delta type
(Homo sapiens (Human)) | BDBM50015677
((S)-1-hydroxymethyl-2-octanoyloxy-ethyl ester | 1,...)Show InChI InChI=1S/C19H36O5/c1-3-5-7-9-11-13-18(21)23-16-17(15-20)24-19(22)14-12-10-8-6-4-2/h17,20H,3-16H2,1-2H3/t17-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL KEGG PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 6.80 | -45.5 | n/a | n/a | n/a | n/a | n/a | 7.4 | 18 |
National Institutes of Health
| Assay Description [3H]PDBu binding to the C1 domains of MRCK alpha/beta and PKC alpha/delta was measured using the polyethylene glycol precipitation assay. |
J Biol Chem 283: 10543-9 (2008)
Article DOI: 10.1074/jbc.M707463200 BindingDB Entry DOI: 10.7270/Q2CF9NQ6 |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM50385658
(CHEMBL2042266)Show SMILES CC(C(=O)NCc1ccc(cc1)C(C)(C)C)c1ccc(NS(C)(=O)=O)c(Br)c1 Show InChI InChI=1S/C21H27BrN2O3S/c1-14(16-8-11-19(18(22)12-16)24-28(5,26)27)20(25)23-13-15-6-9-17(10-7-15)21(2,3)4/h6-12,14,24H,13H2,1-5H3,(H,23,25) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| 7.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Seoul National University
Curated by ChEMBL
| Assay Description Displacement of [3H]RTX from rat TRPV1 receptor expressed in CHO cells after 60 mins by scintillation counting |
Bioorg Med Chem 20: 215-24 (2011)
Article DOI: 10.1016/j.bmc.2011.11.008 BindingDB Entry DOI: 10.7270/Q2MG7QJJ |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM50385671
(CHEMBL2042384)Show SMILES CC(C(=O)NCc1ccc(cc1)C(C)(C)C)c1cc(F)c(NS(C)(=O)=O)c(F)c1 Show InChI InChI=1S/C21H26F2N2O3S/c1-13(15-10-17(22)19(18(23)11-15)25-29(5,27)28)20(26)24-12-14-6-8-16(9-7-14)21(2,3)4/h6-11,13,25H,12H2,1-5H3,(H,24,26) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 7.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Seoul National University
Curated by ChEMBL
| Assay Description Antagonist activity at rat TRPV1 receptor expressed in CHO cells assessed as decrease in capsaicin-induced intracellular 45Ca2+ uptake after 1 hr by ... |
Bioorg Med Chem 20: 215-24 (2011)
Article DOI: 10.1016/j.bmc.2011.11.008 BindingDB Entry DOI: 10.7270/Q2MG7QJJ |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM50385656
(CHEMBL2042264)Show SMILES CC(C(=O)NCc1ccc(cc1)C(C)(C)C)c1ccc(NS(C)(=O)=O)c(F)c1 Show InChI InChI=1S/C21H27FN2O3S/c1-14(16-8-11-19(18(22)12-16)24-28(5,26)27)20(25)23-13-15-6-9-17(10-7-15)21(2,3)4/h6-12,14,24H,13H2,1-5H3,(H,23,25) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 7.60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Seoul National University
Curated by ChEMBL
| Assay Description Antagonist activity at rat TRPV1 receptor expressed in CHO cells assessed as decrease in capsaicin-induced intracellular 45Ca2+ uptake after 1 hr by ... |
Bioorg Med Chem 20: 215-24 (2011)
Article DOI: 10.1016/j.bmc.2011.11.008 BindingDB Entry DOI: 10.7270/Q2MG7QJJ |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM50362800
(CHEMBL1940382)Show SMILES [#6]-[#6](-[#6](=O)-[#7]-[#6]\[#6]=[#6](\c1ccc(-[#6])cc1)-c1ccc(-[#6])cc1)-c1ccc(-[#7]S([#6])(=O)=O)c(F)c1 Show InChI InChI=1S/C27H29FN2O3S/c1-18-5-9-21(10-6-18)24(22-11-7-19(2)8-12-22)15-16-29-27(31)20(3)23-13-14-26(25(28)17-23)30-34(4,32)33/h5-15,17,20,30H,16H2,1-4H3,(H,29,31) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 8 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description Antagonist activity at rat TRPV1 expressed in CHO cells by 45Ca2+ uptake assay |
Bioorg Med Chem 20: 1310-8 (2012)
Article DOI: 10.1016/j.bmc.2011.12.014 BindingDB Entry DOI: 10.7270/Q2ZK5H3M |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50385670
(CHEMBL2042399)Show SMILES C[C@H](C(=O)NCc1ccc(cc1)C(C)(C)C)c1ccc(NS(C)(=O)=O)c(F)c1 |r| Show InChI InChI=1S/C21H27FN2O3S/c1-14(16-8-11-19(18(22)12-16)24-28(5,26)27)20(25)23-13-15-6-9-17(10-7-15)21(2,3)4/h6-12,14,24H,13H2,1-5H3,(H,23,25)/t14-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 8.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Seoul National University
Curated by ChEMBL
| Assay Description Antagonist activity at human TRPV1 receptor expressed in CHO cells assessed as decrease in pH-induced intracellular 45Ca2+ uptake after 1 hr by fluor... |
Bioorg Med Chem 20: 215-24 (2011)
Article DOI: 10.1016/j.bmc.2011.11.008 BindingDB Entry DOI: 10.7270/Q2MG7QJJ |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM20321
(3-[(4-tert-butylphenyl)methyl]-1-[(3-fluoro-4-meth...)Show SMILES CC(C)(C)c1ccc(CNC(=S)NCc2ccc(NS(C)(=O)=O)c(F)c2)cc1 Show InChI InChI=1S/C20H26FN3O2S2/c1-20(2,3)16-8-5-14(6-9-16)12-22-19(27)23-13-15-7-10-18(17(21)11-15)24-28(4,25)26/h5-11,24H,12-13H2,1-4H3,(H2,22,23,27) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 9.16 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Seoul National University
Curated by ChEMBL
| Assay Description Antagonist activity towards rat TRPV1 expressed in CHO cells |
Bioorg Med Chem Lett 15: 4143-50 (2005)
Article DOI: 10.1016/j.bmcl.2005.06.006 BindingDB Entry DOI: 10.7270/Q2JH3KQB |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM20321
(3-[(4-tert-butylphenyl)methyl]-1-[(3-fluoro-4-meth...)Show SMILES CC(C)(C)c1ccc(CNC(=S)NCc2ccc(NS(C)(=O)=O)c(F)c2)cc1 Show InChI InChI=1S/C20H26FN3O2S2/c1-20(2,3)16-8-5-14(6-9-16)12-22-19(27)23-13-15-7-10-18(17(21)11-15)24-28(4,25)26/h5-11,24H,12-13H2,1-4H3,(H2,22,23,27) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 9.20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Seoul National University
Curated by ChEMBL
| Assay Description Antagonist activity at rat TRPV1 receptor expressed in CHO cells assessed as decrease in capsaicin-induced intracellular 45Ca2+ uptake after 1 hr by ... |
Bioorg Med Chem 20: 215-24 (2011)
Article DOI: 10.1016/j.bmc.2011.11.008 BindingDB Entry DOI: 10.7270/Q2MG7QJJ |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM50196366
(2-((3-(2-chloro-4-hydroxy-5-methoxybenzyl)thiourei...)Show SMILES COc1cc(CNC(=S)NCC(COC(=O)C(C)(C)C)Cc2ccc(cc2)C(C)(C)C)c(Cl)cc1O Show InChI InChI=1S/C28H39ClN2O4S/c1-27(2,3)21-10-8-18(9-11-21)12-19(17-35-25(33)28(4,5)6)15-30-26(36)31-16-20-13-24(34-7)23(32)14-22(20)29/h8-11,13-14,19,32H,12,15-17H2,1-7H3,(H2,30,31,36) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 12 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Seoul National University
Curated by ChEMBL
| Assay Description Displacement of [3H]RTX from rat TRPV1 expressed in CHO cells |
Bioorg Med Chem Lett 17: 214-9 (2006)
Article DOI: 10.1016/j.bmcl.2006.09.059 BindingDB Entry DOI: 10.7270/Q27D2TSX |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase MRCK beta
(Homo sapiens (Human)) | BDBM92596
(Sapintoxin D)Show SMILES CCCC(=O)O[C@@]12C(C3CC(=O)C[C@@]4(O)C(C=C(C)C4=O)[C@]3(O)[C@@H](C)[C@H]1OC(=O)c1ccccc1NC)C2(C)C |r,t:16| Show InChI InChI=1S/C31H39NO8/c1-7-10-23(34)40-31-24(28(31,4)5)20-14-18(33)15-29(37)22(13-16(2)25(29)35)30(20,38)17(3)26(31)39-27(36)19-11-8-9-12-21(19)32-6/h8-9,11-13,17,20,22,24,26,32,37-38H,7,10,14-15H2,1-6H3/t17-,20?,22?,24?,26+,29+,30-,31-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| 12.6 | -44.0 | n/a | n/a | n/a | n/a | n/a | 7.4 | 18 |
National Institutes of Health
| Assay Description [3H]PDBu binding to the C1 domains of MRCK alpha/beta and PKC alpha/delta was measured using the polyethylene glycol precipitation assay. |
J Biol Chem 283: 10543-9 (2008)
Article DOI: 10.1074/jbc.M707463200 BindingDB Entry DOI: 10.7270/Q2CF9NQ6 |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50385656
(CHEMBL2042264)Show SMILES CC(C(=O)NCc1ccc(cc1)C(C)(C)C)c1ccc(NS(C)(=O)=O)c(F)c1 Show InChI InChI=1S/C21H27FN2O3S/c1-14(16-8-11-19(18(22)12-16)24-28(5,26)27)20(25)23-13-15-6-9-17(10-7-15)21(2,3)4/h6-12,14,24H,13H2,1-5H3,(H,23,25) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 12.7 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Seoul National University
Curated by ChEMBL
| Assay Description Antagonist activity at human TRPV1 receptor expressed in CHO cells assessed as decrease in pH-induced intracellular 45Ca2+ uptake after 1 hr by fluor... |
Bioorg Med Chem 20: 215-24 (2011)
Article DOI: 10.1016/j.bmc.2011.11.008 BindingDB Entry DOI: 10.7270/Q2MG7QJJ |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM50362810
(CHEMBL1940207)Show SMILES CC(C(=O)NCc1ccc(cc1Br)C(C)(C)C)c1ccc(NS(C)(=O)=O)c(F)c1 Show InChI InChI=1S/C21H26BrFN2O3S/c1-13(14-7-9-19(18(23)10-14)25-29(5,27)28)20(26)24-12-15-6-8-16(11-17(15)22)21(2,3)4/h6-11,13,25H,12H2,1-5H3,(H,24,26) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 12.7 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description Antagonist activity at rat TRPV1 expressed in CHO cells by 45Ca2+ uptake assay |
Bioorg Med Chem 20: 1310-8 (2012)
Article DOI: 10.1016/j.bmc.2011.12.014 BindingDB Entry DOI: 10.7270/Q2ZK5H3M |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM50196365
(2-((3-(4-hydroxy-2-iodo-5-methoxybenzyl)thioureido...)Show SMILES COc1cc(CNC(=S)NCC(COC(=O)C(C)(C)C)Cc2ccc(cc2)C(C)(C)C)c(I)cc1O Show InChI InChI=1S/C28H39IN2O4S/c1-27(2,3)21-10-8-18(9-11-21)12-19(17-35-25(33)28(4,5)6)15-30-26(36)31-16-20-13-24(34-7)23(32)14-22(20)29/h8-11,13-14,19,32H,12,15-17H2,1-7H3,(H2,30,31,36) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 13 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Seoul National University
Curated by ChEMBL
| Assay Description Displacement of [3H]RTX from rat TRPV1 expressed in CHO cells |
Bioorg Med Chem Lett 17: 214-9 (2006)
Article DOI: 10.1016/j.bmcl.2006.09.059 BindingDB Entry DOI: 10.7270/Q27D2TSX |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM50196341
(2-((3-(2-bromo-4-hydroxy-5-methoxybenzyl)thioureid...)Show SMILES COc1cc(CNC(=S)NCC(COC(=O)C(C)(C)C)Cc2ccc(cc2)C(C)(C)C)c(Br)cc1O Show InChI InChI=1S/C28H39BrN2O4S/c1-27(2,3)21-10-8-18(9-11-21)12-19(17-35-25(33)28(4,5)6)15-30-26(36)31-16-20-13-24(34-7)23(32)14-22(20)29/h8-11,13-14,19,32H,12,15-17H2,1-7H3,(H2,30,31,36) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 13 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Seoul National University
Curated by ChEMBL
| Assay Description Displacement of [3H]RTX from rat TRPV1 expressed in CHO cells |
Bioorg Med Chem Lett 17: 214-9 (2006)
Article DOI: 10.1016/j.bmcl.2006.09.059 BindingDB Entry DOI: 10.7270/Q27D2TSX |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM50196365
(2-((3-(4-hydroxy-2-iodo-5-methoxybenzyl)thioureido...)Show SMILES COc1cc(CNC(=S)NCC(COC(=O)C(C)(C)C)Cc2ccc(cc2)C(C)(C)C)c(I)cc1O Show InChI InChI=1S/C28H39IN2O4S/c1-27(2,3)21-10-8-18(9-11-21)12-19(17-35-25(33)28(4,5)6)15-30-26(36)31-16-20-13-24(34-7)23(32)14-22(20)29/h8-11,13-14,19,32H,12,15-17H2,1-7H3,(H2,30,31,36) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 13.3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Seoul National University
Curated by ChEMBL
| Assay Description Displacement of [3H]RTX from rat TRPV1 expressed in CHO cells |
Bioorg Med Chem Lett 17: 214-9 (2006)
Article DOI: 10.1016/j.bmcl.2006.09.059 BindingDB Entry DOI: 10.7270/Q27D2TSX |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM50362796
(CHEMBL1940378)Show SMILES [#6]-[#6](-[#6](=O)-[#7]-[#6]\[#6]=[#6](/c1ccccc1)-c1ccccc1)-c1ccc(-[#7]S([#6])(=O)=O)c(F)c1 Show InChI InChI=1S/C25H25FN2O3S/c1-18(21-13-14-24(23(26)17-21)28-32(2,30)31)25(29)27-16-15-22(19-9-5-3-6-10-19)20-11-7-4-8-12-20/h3-15,17-18,28H,16H2,1-2H3,(H,27,29) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 14.2 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description Antagonist activity at rat TRPV1 expressed in CHO cells by 45Ca2+ uptake assay |
Bioorg Med Chem 20: 1310-8 (2012)
Article DOI: 10.1016/j.bmc.2011.12.014 BindingDB Entry DOI: 10.7270/Q2ZK5H3M |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM50362814
(CHEMBL1940203)Show SMILES CC(C(=O)NCc1ccc(cc1)C1CCC=C1)c1ccc(NS(C)(=O)=O)c(F)c1 |c:16| Show InChI InChI=1S/C22H25FN2O3S/c1-15(19-11-12-21(20(23)13-19)25-29(2,27)28)22(26)24-14-16-7-9-18(10-8-16)17-5-3-4-6-17/h3,5,7-13,15,17,25H,4,6,14H2,1-2H3,(H,24,26) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 15 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description Antagonist activity at rat TRPV1 expressed in CHO cells by 45Ca2+ uptake assay |
Bioorg Med Chem 20: 1310-8 (2012)
Article DOI: 10.1016/j.bmc.2011.12.014 BindingDB Entry DOI: 10.7270/Q2ZK5H3M |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50385670
(CHEMBL2042399)Show SMILES C[C@H](C(=O)NCc1ccc(cc1)C(C)(C)C)c1ccc(NS(C)(=O)=O)c(F)c1 |r| Show InChI InChI=1S/C21H27FN2O3S/c1-14(16-8-11-19(18(22)12-16)24-28(5,26)27)20(25)23-13-15-6-9-17(10-7-15)21(2,3)4/h6-12,14,24H,13H2,1-5H3,(H,23,25)/t14-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 15.8 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Seoul National University
Curated by ChEMBL
| Assay Description Displacement of [3H]RTX from human TRPV1 receptor expressed in CHO cells after 60 mins by scintillation counting |
Bioorg Med Chem 20: 215-24 (2011)
Article DOI: 10.1016/j.bmc.2011.11.008 BindingDB Entry DOI: 10.7270/Q2MG7QJJ |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM50196337
(2,2-Dimethyl-propionic acid 2-(3,4-dimethyl-benzyl...)Show SMILES COc1cc(CNC(=S)NCC(COC(=O)C(C)(C)C)Cc2ccc(C)c(C)c2)ccc1O Show InChI InChI=1S/C26H36N2O4S/c1-17-7-8-19(11-18(17)2)12-21(16-32-24(30)26(3,4)5)15-28-25(33)27-14-20-9-10-22(29)23(13-20)31-6/h7-11,13,21,29H,12,14-16H2,1-6H3,(H2,27,28,33) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 17 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Seoul National University
Curated by ChEMBL
| Assay Description Displacement of [3H]RTX from rat TRPV1 expressed in CHO cells |
Bioorg Med Chem Lett 17: 214-9 (2006)
Article DOI: 10.1016/j.bmcl.2006.09.059 BindingDB Entry DOI: 10.7270/Q27D2TSX |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM50385655
(CHEMBL2042263)Show SMILES CC(C(=O)NCc1ccc(cc1)C(C)(C)C)c1ccc(NS(C)(=O)=O)cc1 Show InChI InChI=1S/C21H28N2O3S/c1-15(17-8-12-19(13-9-17)23-27(5,25)26)20(24)22-14-16-6-10-18(11-7-16)21(2,3)4/h6-13,15,23H,14H2,1-5H3,(H,22,24) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 17.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Seoul National University
Curated by ChEMBL
| Assay Description Antagonist activity at rat TRPV1 receptor expressed in CHO cells assessed as decrease in capsaicin-induced intracellular 45Ca2+ uptake after 1 hr by ... |
Bioorg Med Chem 20: 215-24 (2011)
Article DOI: 10.1016/j.bmc.2011.11.008 BindingDB Entry DOI: 10.7270/Q2MG7QJJ |
More data for this Ligand-Target Pair | |
Protein kinase C alpha type
(Homo sapiens (Human)) | BDBM92596
(Sapintoxin D)Show SMILES CCCC(=O)O[C@@]12C(C3CC(=O)C[C@@]4(O)C(C=C(C)C4=O)[C@]3(O)[C@@H](C)[C@H]1OC(=O)c1ccccc1NC)C2(C)C |r,t:16| Show InChI InChI=1S/C31H39NO8/c1-7-10-23(34)40-31-24(28(31,4)5)20-14-18(33)15-29(37)22(13-16(2)25(29)35)30(20,38)17(3)26(31)39-27(36)19-11-8-9-12-21(19)32-6/h8-9,11-13,17,20,22,24,26,32,37-38H,7,10,14-15H2,1-6H3/t17-,20?,22?,24?,26+,29+,30-,31-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| 18.2 | -43.1 | n/a | n/a | n/a | n/a | n/a | 7.4 | 18 |
National Institutes of Health
| Assay Description [3H]PDBu binding to the C1 domains of MRCK alpha/beta and PKC alpha/delta was measured using the polyethylene glycol precipitation assay. |
J Biol Chem 283: 10543-9 (2008)
Article DOI: 10.1074/jbc.M707463200 BindingDB Entry DOI: 10.7270/Q2CF9NQ6 |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM50385667
(CHEMBL2042396)Show SMILES CC(C(=O)NCc1ccc(cc1)C(C)(C)C)c1ccc(NS(C)(=O)=O)c(C)c1 Show InChI InChI=1S/C22H30N2O3S/c1-15-13-18(9-12-20(15)24-28(6,26)27)16(2)21(25)23-14-17-7-10-19(11-8-17)22(3,4)5/h7-13,16,24H,14H2,1-6H3,(H,23,25) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 18.9 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Seoul National University
Curated by ChEMBL
| Assay Description Antagonist activity at rat TRPV1 receptor expressed in CHO cells assessed as decrease in capsaicin-induced intracellular 45Ca2+ uptake after 1 hr by ... |
Bioorg Med Chem 20: 215-24 (2011)
Article DOI: 10.1016/j.bmc.2011.11.008 BindingDB Entry DOI: 10.7270/Q2MG7QJJ |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM50196336
(2-((3-(4-hydroxy-2-iodo-5-methoxybenzyl)thioureido...)Show SMILES COc1cc(CNC(=S)NCC(COC(=O)C(C)(C)C)Cc2ccc(C)c(C)c2)c(I)cc1O Show InChI InChI=1S/C26H35IN2O4S/c1-16-7-8-18(9-17(16)2)10-19(15-33-24(31)26(3,4)5)13-28-25(34)29-14-20-11-23(32-6)22(30)12-21(20)27/h7-9,11-12,19,30H,10,13-15H2,1-6H3,(H2,28,29,34) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 19 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Seoul National University
Curated by ChEMBL
| Assay Description Displacement of [3H]RTX from rat TRPV1 expressed in CHO cells |
Bioorg Med Chem Lett 17: 214-9 (2006)
Article DOI: 10.1016/j.bmcl.2006.09.059 BindingDB Entry DOI: 10.7270/Q27D2TSX |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM50196354
(2-((3-(3-bromo-4-hydroxy-5-methoxybenzyl)thioureid...)Show SMILES COc1cc(CNC(=S)NCC(COC(=O)C(C)(C)C)Cc2ccc(cc2)C(C)(C)C)cc(Br)c1O Show InChI InChI=1S/C28H39BrN2O4S/c1-27(2,3)21-10-8-18(9-11-21)12-20(17-35-25(33)28(4,5)6)16-31-26(36)30-15-19-13-22(29)24(32)23(14-19)34-7/h8-11,13-14,20,32H,12,15-17H2,1-7H3,(H2,30,31,36) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 19 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Seoul National University
Curated by ChEMBL
| Assay Description Displacement of [3H]RTX from rat TRPV1 expressed in CHO cells |
Bioorg Med Chem Lett 17: 214-9 (2006)
Article DOI: 10.1016/j.bmcl.2006.09.059 BindingDB Entry DOI: 10.7270/Q27D2TSX |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM50385671
(CHEMBL2042384)Show SMILES CC(C(=O)NCc1ccc(cc1)C(C)(C)C)c1cc(F)c(NS(C)(=O)=O)c(F)c1 Show InChI InChI=1S/C21H26F2N2O3S/c1-13(15-10-17(22)19(18(23)11-15)25-29(5,27)28)20(26)24-12-14-6-8-16(9-7-14)21(2,3)4/h6-11,13,25H,12H2,1-5H3,(H,24,26) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 19.9 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Seoul National University
Curated by ChEMBL
| Assay Description Displacement of [3H]RTX from rat TRPV1 receptor expressed in CHO cells after 60 mins by scintillation counting |
Bioorg Med Chem 20: 215-24 (2011)
Article DOI: 10.1016/j.bmc.2011.11.008 BindingDB Entry DOI: 10.7270/Q2MG7QJJ |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM50196367
(2-((3-(2-bromo-4-hydroxy-5-methoxybenzyl)thioureid...)Show SMILES COc1cc(CNC(=S)NCC(COC(=O)C(C)(C)C)Cc2ccc(C)c(C)c2)c(Br)cc1O Show InChI InChI=1S/C26H35BrN2O4S/c1-16-7-8-18(9-17(16)2)10-19(15-33-24(31)26(3,4)5)13-28-25(34)29-14-20-11-23(32-6)22(30)12-21(20)27/h7-9,11-12,19,30H,10,13-15H2,1-6H3,(H2,28,29,34) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Seoul National University
Curated by ChEMBL
| Assay Description Displacement of [3H]RTX from rat TRPV1 expressed in CHO cells |
Bioorg Med Chem Lett 17: 214-9 (2006)
Article DOI: 10.1016/j.bmcl.2006.09.059 BindingDB Entry DOI: 10.7270/Q27D2TSX |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM50362813
(CHEMBL1940204)Show SMILES CC(C(=O)NCc1ccc(cc1)C1CCCC1)c1ccc(NS(C)(=O)=O)c(F)c1 Show InChI InChI=1S/C22H27FN2O3S/c1-15(19-11-12-21(20(23)13-19)25-29(2,27)28)22(26)24-14-16-7-9-18(10-8-16)17-5-3-4-6-17/h7-13,15,17,25H,3-6,14H2,1-2H3,(H,24,26) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 20.8 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description Antagonist activity at rat TRPV1 expressed in CHO cells by 45Ca2+ uptake assay |
Bioorg Med Chem 20: 1310-8 (2012)
Article DOI: 10.1016/j.bmc.2011.12.014 BindingDB Entry DOI: 10.7270/Q2ZK5H3M |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM50196352
(2-((3-(3-chloro-4-hydroxy-5-methoxybenzyl)thiourei...)Show SMILES COc1cc(CNC(=S)NCC(COC(=O)C(C)(C)C)Cc2ccc(cc2)C(C)(C)C)cc(Cl)c1O Show InChI InChI=1S/C28H39ClN2O4S/c1-27(2,3)21-10-8-18(9-11-21)12-20(17-35-25(33)28(4,5)6)16-31-26(36)30-15-19-13-22(29)24(32)23(14-19)34-7/h8-11,13-14,20,32H,12,15-17H2,1-7H3,(H2,30,31,36) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 21 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Seoul National University
Curated by ChEMBL
| Assay Description Displacement of [3H]RTX from rat TRPV1 expressed in CHO cells |
Bioorg Med Chem Lett 17: 214-9 (2006)
Article DOI: 10.1016/j.bmcl.2006.09.059 BindingDB Entry DOI: 10.7270/Q27D2TSX |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM50362796
(CHEMBL1940378)Show SMILES [#6]-[#6](-[#6](=O)-[#7]-[#6]\[#6]=[#6](/c1ccccc1)-c1ccccc1)-c1ccc(-[#7]S([#6])(=O)=O)c(F)c1 Show InChI InChI=1S/C25H25FN2O3S/c1-18(21-13-14-24(23(26)17-21)28-32(2,30)31)25(29)27-16-15-22(19-9-5-3-6-10-19)20-11-7-4-8-12-20/h3-15,17-18,28H,16H2,1-2H3,(H,27,29) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 21.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description Displacement of [3H]RTX from rat TRPV1 expressed in CHO cells |
Bioorg Med Chem 20: 1310-8 (2012)
Article DOI: 10.1016/j.bmc.2011.12.014 BindingDB Entry DOI: 10.7270/Q2ZK5H3M |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM50196336
(2-((3-(4-hydroxy-2-iodo-5-methoxybenzyl)thioureido...)Show SMILES COc1cc(CNC(=S)NCC(COC(=O)C(C)(C)C)Cc2ccc(C)c(C)c2)c(I)cc1O Show InChI InChI=1S/C26H35IN2O4S/c1-16-7-8-18(9-17(16)2)10-19(15-33-24(31)26(3,4)5)13-28-25(34)29-14-20-11-23(32-6)22(30)12-21(20)27/h7-9,11-12,19,30H,10,13-15H2,1-6H3,(H2,28,29,34) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 23 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Seoul National University
Curated by ChEMBL
| Assay Description Antagonist activity at rat TRPV1 expressed in CHO cells assessed as inhibition of calcium uptake |
Bioorg Med Chem Lett 17: 214-9 (2006)
Article DOI: 10.1016/j.bmcl.2006.09.059 BindingDB Entry DOI: 10.7270/Q27D2TSX |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM50385659
(CHEMBL2042383)Show SMILES CC(C(=O)NCc1ccc(cc1)C(C)(C)C)c1ccc(NS(C)(=O)=O)c(I)c1 Show InChI InChI=1S/C21H27IN2O3S/c1-14(16-8-11-19(18(22)12-16)24-28(5,26)27)20(25)23-13-15-6-9-17(10-7-15)21(2,3)4/h6-12,14,24H,13H2,1-5H3,(H,23,25) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| 23.3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Seoul National University
Curated by ChEMBL
| Assay Description Displacement of [3H]RTX from rat TRPV1 receptor expressed in CHO cells after 60 mins by scintillation counting |
Bioorg Med Chem 20: 215-24 (2011)
Article DOI: 10.1016/j.bmc.2011.11.008 BindingDB Entry DOI: 10.7270/Q2MG7QJJ |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM50362823
(CHEMBL1940193)Show SMILES CC(NC(=O)\C=C\c1ccc(cc1)C(C)(C)C)c1ccc(NS(C)(=O)=O)c(F)c1 Show InChI InChI=1S/C22H27FN2O3S/c1-15(17-9-12-20(19(23)14-17)25-29(5,27)28)24-21(26)13-8-16-6-10-18(11-7-16)22(2,3)4/h6-15,25H,1-5H3,(H,24,26)/b13-8+ | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 23.9 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description Antagonist activity at rat TRPV1 expressed in CHO cells by 45Ca2+ uptake assay |
Bioorg Med Chem 20: 1310-8 (2012)
Article DOI: 10.1016/j.bmc.2011.12.014 BindingDB Entry DOI: 10.7270/Q2ZK5H3M |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM50196357
(2-((3-(2-chloro-4-hydroxy-5-methoxybenzyl)thiourei...)Show SMILES COc1cc(CNC(=S)NCC(COC(=O)C(C)(C)C)Cc2ccc(C)c(C)c2)c(Cl)cc1O Show InChI InChI=1S/C26H35ClN2O4S/c1-16-7-8-18(9-17(16)2)10-19(15-33-24(31)26(3,4)5)13-28-25(34)29-14-20-11-23(32-6)22(30)12-21(20)27/h7-9,11-12,19,30H,10,13-15H2,1-6H3,(H2,28,29,34) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 24 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Seoul National University
Curated by ChEMBL
| Assay Description Displacement of [3H]RTX from rat TRPV1 expressed in CHO cells |
Bioorg Med Chem Lett 17: 214-9 (2006)
Article DOI: 10.1016/j.bmcl.2006.09.059 BindingDB Entry DOI: 10.7270/Q27D2TSX |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM50385670
(CHEMBL2042399)Show SMILES C[C@H](C(=O)NCc1ccc(cc1)C(C)(C)C)c1ccc(NS(C)(=O)=O)c(F)c1 |r| Show InChI InChI=1S/C21H27FN2O3S/c1-14(16-8-11-19(18(22)12-16)24-28(5,26)27)20(25)23-13-15-6-9-17(10-7-15)21(2,3)4/h6-12,14,24H,13H2,1-5H3,(H,23,25)/t14-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 24.4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Seoul National University
Curated by ChEMBL
| Assay Description Displacement of [3H]RTX from rat TRPV1 receptor expressed in CHO cells after 60 mins by scintillation counting |
Bioorg Med Chem 20: 215-24 (2011)
Article DOI: 10.1016/j.bmc.2011.11.008 BindingDB Entry DOI: 10.7270/Q2MG7QJJ |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM50362803
(CHEMBL1940385)Show SMILES [#6]-[#6](-[#6](=O)-[#7]-[#6]\[#6]=[#6](\c1ccc(Cl)cc1)-c1ccc(Cl)cc1)-c1ccc(-[#7]S([#6])(=O)=O)c(F)c1 Show InChI InChI=1S/C25H23Cl2FN2O3S/c1-16(19-7-12-24(23(28)15-19)30-34(2,32)33)25(31)29-14-13-22(17-3-8-20(26)9-4-17)18-5-10-21(27)11-6-18/h3-13,15-16,30H,14H2,1-2H3,(H,29,31) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 24.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description Antagonist activity at rat TRPV1 expressed in CHO cells by 45Ca2+ uptake assay |
Bioorg Med Chem 20: 1310-8 (2012)
Article DOI: 10.1016/j.bmc.2011.12.014 BindingDB Entry DOI: 10.7270/Q2ZK5H3M |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM50362801
(CHEMBL1940383)Show SMILES CC(C(=O)NCCC(c1ccc(F)cc1)c1ccc(F)cc1)c1ccc(NS(C)(=O)=O)c(F)c1 Show InChI InChI=1S/C25H25F3N2O3S/c1-16(19-7-12-24(23(28)15-19)30-34(2,32)33)25(31)29-14-13-22(17-3-8-20(26)9-4-17)18-5-10-21(27)11-6-18/h3-12,15-16,22,30H,13-14H2,1-2H3,(H,29,31) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 24.8 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description Antagonist activity at rat TRPV1 expressed in CHO cells by 45Ca2+ uptake assay |
Bioorg Med Chem 20: 1310-8 (2012)
Article DOI: 10.1016/j.bmc.2011.12.014 BindingDB Entry DOI: 10.7270/Q2ZK5H3M |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM50385658
(CHEMBL2042266)Show SMILES CC(C(=O)NCc1ccc(cc1)C(C)(C)C)c1ccc(NS(C)(=O)=O)c(Br)c1 Show InChI InChI=1S/C21H27BrN2O3S/c1-14(16-8-11-19(18(22)12-16)24-28(5,26)27)20(25)23-13-15-6-9-17(10-7-15)21(2,3)4/h6-12,14,24H,13H2,1-5H3,(H,23,25) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| 25 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Seoul National University
Curated by ChEMBL
| Assay Description Antagonist activity at rat TRPV1 receptor expressed in CHO cells assessed as decrease in capsaicin-induced intracellular 45Ca2+ uptake after 1 hr by ... |
Bioorg Med Chem 20: 215-24 (2011)
Article DOI: 10.1016/j.bmc.2011.11.008 BindingDB Entry DOI: 10.7270/Q2MG7QJJ |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM50196335
(2-(3-(3-chloro-4-hydroxy-5-methoxybenzyl)thioureid...)Show SMILES COc1cc(CNC(=S)NC(COC(=O)C(C)(C)C)Cc2ccc(cc2)C(C)(C)C)cc(Cl)c1O Show InChI InChI=1S/C27H37ClN2O4S/c1-26(2,3)19-10-8-17(9-11-19)12-20(16-34-24(32)27(4,5)6)30-25(35)29-15-18-13-21(28)23(31)22(14-18)33-7/h8-11,13-14,20,31H,12,15-16H2,1-7H3,(H2,29,30,35) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 29 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Seoul National University
Curated by ChEMBL
| Assay Description Displacement of [3H]RTX from rat TRPV1 expressed in CHO cells |
Bioorg Med Chem Lett 17: 214-9 (2006)
Article DOI: 10.1016/j.bmcl.2006.09.059 BindingDB Entry DOI: 10.7270/Q27D2TSX |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM50362802
(CHEMBL1940384)Show SMILES [#6]-[#6](-[#6](=O)-[#7]-[#6]\[#6]=[#6](\c1ccc(F)cc1)-c1ccc(F)cc1)-c1ccc(-[#7]S([#6])(=O)=O)c(F)c1 Show InChI InChI=1S/C25H23F3N2O3S/c1-16(19-7-12-24(23(28)15-19)30-34(2,32)33)25(31)29-14-13-22(17-3-8-20(26)9-4-17)18-5-10-21(27)11-6-18/h3-13,15-16,30H,14H2,1-2H3,(H,29,31) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 29.2 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description Antagonist activity at rat TRPV1 expressed in CHO cells by 45Ca2+ uptake assay |
Bioorg Med Chem 20: 1310-8 (2012)
Article DOI: 10.1016/j.bmc.2011.12.014 BindingDB Entry DOI: 10.7270/Q2ZK5H3M |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM50385657
(CHEMBL2042265)Show SMILES CC(C(=O)NCc1ccc(cc1)C(C)(C)C)c1ccc(NS(C)(=O)=O)c(Cl)c1 Show InChI InChI=1S/C21H27ClN2O3S/c1-14(16-8-11-19(18(22)12-16)24-28(5,26)27)20(25)23-13-15-6-9-17(10-7-15)21(2,3)4/h6-12,14,24H,13H2,1-5H3,(H,23,25) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| 29.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Seoul National University
Curated by ChEMBL
| Assay Description Antagonist activity at rat TRPV1 receptor expressed in CHO cells assessed as decrease in capsaicin-induced intracellular 45Ca2+ uptake after 1 hr by ... |
Bioorg Med Chem 20: 215-24 (2011)
Article DOI: 10.1016/j.bmc.2011.11.008 BindingDB Entry DOI: 10.7270/Q2MG7QJJ |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM50362803
(CHEMBL1940385)Show SMILES [#6]-[#6](-[#6](=O)-[#7]-[#6]\[#6]=[#6](\c1ccc(Cl)cc1)-c1ccc(Cl)cc1)-c1ccc(-[#7]S([#6])(=O)=O)c(F)c1 Show InChI InChI=1S/C25H23Cl2FN2O3S/c1-16(19-7-12-24(23(28)15-19)30-34(2,32)33)25(31)29-14-13-22(17-3-8-20(26)9-4-17)18-5-10-21(27)11-6-18/h3-13,15-16,30H,14H2,1-2H3,(H,29,31) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 29.6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description Displacement of [3H]RTX from rat TRPV1 expressed in CHO cells |
Bioorg Med Chem 20: 1310-8 (2012)
Article DOI: 10.1016/j.bmc.2011.12.014 BindingDB Entry DOI: 10.7270/Q2ZK5H3M |
More data for this Ligand-Target Pair | |