Found 227 hits with Last Name = 'leber' and Initial = 'jd' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
RAC-alpha serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50316184
(4-(2-(4-amino-1,2,5-oxadiazol-3-yl)-6-((S)-3-amino...)Show SMILES CCn1c(nc2c(nc(O[C@@H](CCN)c3ccccc3)cc12)C#CC(C)(C)O)-c1nonc1N |r| Show InChI InChI=1S/C24H27N7O3/c1-4-31-17-14-19(33-18(11-13-25)15-8-6-5-7-9-15)27-16(10-12-24(2,3)32)20(17)28-23(31)21-22(26)30-34-29-21/h5-9,14,18,32H,4,11,13,25H2,1-3H3,(H2,26,30)/t18-/m0/s1 | PDB
UniProtKB/SwissProt
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| CHEMBL MMDB PC cid PC sid UniChem
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| Article PubMed
| 0.200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Inhibition of AKT |
Bioorg Med Chem Lett 19: 1508-11 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.002 BindingDB Entry DOI: 10.7270/Q2XK8FP7 |
More data for this Ligand-Target Pair | |
RAC-alpha serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50316183
(4-(2-(4-amino-1,2,5-oxadiazol-3-yl)-6-((R)-2-amino...)Show SMILES CCn1c(nc2c(nc(OC[C@H](N)Cc3ccccc3)cc12)C#CC(C)(C)O)-c1nonc1N |r| Show InChI InChI=1S/C24H27N7O3/c1-4-31-18-13-19(33-14-16(25)12-15-8-6-5-7-9-15)27-17(10-11-24(2,3)32)20(18)28-23(31)21-22(26)30-34-29-21/h5-9,13,16,32H,4,12,14,25H2,1-3H3,(H2,26,30)/t16-/m1/s1 | PDB
UniProtKB/SwissProt
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| PDB Article PubMed
| 0.200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Inhibition of AKT |
Bioorg Med Chem Lett 19: 1508-11 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.002 BindingDB Entry DOI: 10.7270/Q2XK8FP7 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
RAC-alpha serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50316192
(4-(2-(4-amino-1,2,5-oxadiazol-3-yl)-6-((R)-2-amino...)Show SMILES CCn1c(nc2c(nc(O[C@@H](CN)c3ccccc3)cc12)C#CC(C)(C)O)-c1nonc1N |r| Show InChI InChI=1S/C23H25N7O3/c1-4-30-16-12-18(32-17(13-24)14-8-6-5-7-9-14)26-15(10-11-23(2,3)31)19(16)27-22(30)20-21(25)29-33-28-20/h5-9,12,17,31H,4,13,24H2,1-3H3,(H2,25,29)/t17-/m0/s1 | PDB
UniProtKB/SwissProt
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| Article PubMed
| 0.400 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Inhibition of AKT |
Bioorg Med Chem Lett 19: 1508-11 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.002 BindingDB Entry DOI: 10.7270/Q2XK8FP7 |
More data for this Ligand-Target Pair | |
Endothelin-1 receptor
(Homo sapiens (Human)) | BDBM50041617
((1S,2R,3S)-1-Benzo[1,3]dioxol-5-yl-3-(2-carboxymet...)Show SMILES CCCOc1ccc2[C@@H]([C@H]([C@@H](c2c1)c1ccc(OC)cc1OCC(O)=O)C(O)=O)c1ccc2OCOc2c1 Show InChI InChI=1S/C29H28O9/c1-3-10-35-18-6-7-19-21(12-18)27(20-8-5-17(34-2)13-23(20)36-14-25(30)31)28(29(32)33)26(19)16-4-9-22-24(11-16)38-15-37-22/h4-9,11-13,26-28H,3,10,14-15H2,1-2H3,(H,30,31)(H,32,33)/t26-,27+,28+/m0/s1 | PDB
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| 0.430 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals
Curated by ChEMBL
| Assay Description Inhibition of [125I]-ET-1 binding to cloned human ET-A receptor |
J Med Chem 37: 1553-7 (1994)
BindingDB Entry DOI: 10.7270/Q2154G2V |
More data for this Ligand-Target Pair | |
Leukotriene B4 receptor 1
(Homo sapiens (Human)) | BDBM50042149
(CHEMBL112520 | Lithium; 3-{1-hydroxy-2-[6-(3-hydro...)Show SMILES CCCCCCCCC(O)\C=C\c1cccc(CC(O)c2cccc(c2)C([O-])=O)n1 Show InChI InChI=1S/C25H33NO4/c1-2-3-4-5-6-7-14-23(27)16-15-21-12-9-13-22(26-21)18-24(28)19-10-8-11-20(17-19)25(29)30/h8-13,15-17,23-24,27-28H,2-7,14,18H2,1H3,(H,29,30)/p-1/b16-15+ | PDB
UniProtKB/SwissProt
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| 1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals
Curated by ChEMBL
| Assay Description Inhibition of [3H]- LTB4 binding on human whole cells |
J Med Chem 36: 3308-20 (1993)
BindingDB Entry DOI: 10.7270/Q21R6R4P |
More data for this Ligand-Target Pair | |
RAC-beta serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50316184
(4-(2-(4-amino-1,2,5-oxadiazol-3-yl)-6-((S)-3-amino...)Show SMILES CCn1c(nc2c(nc(O[C@@H](CCN)c3ccccc3)cc12)C#CC(C)(C)O)-c1nonc1N |r| Show InChI InChI=1S/C24H27N7O3/c1-4-31-17-14-19(33-18(11-13-25)15-8-6-5-7-9-15)27-16(10-12-24(2,3)32)20(17)28-23(31)21-22(26)30-34-29-21/h5-9,14,18,32H,4,11,13,25H2,1-3H3,(H2,26,30)/t18-/m0/s1 | PDB
UniProtKB/SwissProt
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| 1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Inhibition of AKT2 |
Bioorg Med Chem Lett 19: 1508-11 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.002 BindingDB Entry DOI: 10.7270/Q2XK8FP7 |
More data for this Ligand-Target Pair | |
RAC-alpha serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM25013
(4-[2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-[(3S...)Show SMILES CCn1c(nc2c(ncc(OC[C@H]3CCCNC3)c12)C#CC(C)(C)O)-c1nonc1N |r| Show InChI InChI=1S/C21H27N7O3/c1-4-28-18-15(30-12-13-6-5-9-23-10-13)11-24-14(7-8-21(2,3)29)16(18)25-20(28)17-19(22)27-31-26-17/h11,13,23,29H,4-6,9-10,12H2,1-3H3,(H2,22,27)/t13-/m0/s1 | PDB
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| 1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Inhibition of AKT |
Bioorg Med Chem Lett 19: 1508-11 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.002 BindingDB Entry DOI: 10.7270/Q2XK8FP7 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
RAC-alpha serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50316185
(4-(2-(4-amino-1,2,5-oxadiazol-3-yl)-6-((R)-3-amino...)Show SMILES CCn1c(nc2c(nc(O[C@H](CCN)c3ccccc3)cc12)C#CC(C)(C)O)-c1nonc1N |r| Show InChI InChI=1S/C24H27N7O3/c1-4-31-17-14-19(33-18(11-13-25)15-8-6-5-7-9-15)27-16(10-12-24(2,3)32)20(17)28-23(31)21-22(26)30-34-29-21/h5-9,14,18,32H,4,11,13,25H2,1-3H3,(H2,26,30)/t18-/m1/s1 | PDB
UniProtKB/SwissProt
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| 1.90 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Inhibition of AKT |
Bioorg Med Chem Lett 19: 1508-11 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.002 BindingDB Entry DOI: 10.7270/Q2XK8FP7 |
More data for this Ligand-Target Pair | |
RAC-beta serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50316183
(4-(2-(4-amino-1,2,5-oxadiazol-3-yl)-6-((R)-2-amino...)Show SMILES CCn1c(nc2c(nc(OC[C@H](N)Cc3ccccc3)cc12)C#CC(C)(C)O)-c1nonc1N |r| Show InChI InChI=1S/C24H27N7O3/c1-4-31-18-13-19(33-14-16(25)12-15-8-6-5-7-9-15)27-17(10-11-24(2,3)32)20(18)28-23(31)21-22(26)30-34-29-21/h5-9,13,16,32H,4,12,14,25H2,1-3H3,(H2,26,30)/t16-/m1/s1 | PDB
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| 2 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Inhibition of AKT2 |
Bioorg Med Chem Lett 19: 1508-11 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.002 BindingDB Entry DOI: 10.7270/Q2XK8FP7 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Leukotriene B4 receptor 1
(Homo sapiens (Human)) | BDBM50042153
(CHEMBL113288 | Lithium; 3-(2-{7-[3-(3-butoxy-pheny...)Show SMILES CCCCOc1cccc(c1)C(O)\C=C\c1cccc(CC(O)c2cccc(c2)C([O-])=O)n1 Show InChI InChI=1S/C27H29NO5/c1-2-3-15-33-24-12-5-8-20(17-24)25(29)14-13-22-10-6-11-23(28-22)18-26(30)19-7-4-9-21(16-19)27(31)32/h4-14,16-17,25-26,29-30H,2-3,15,18H2,1H3,(H,31,32)/p-1/b14-13+ | PDB
UniProtKB/SwissProt
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| 3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals
Curated by ChEMBL
| Assay Description Inhibition of [3H]- LTB4 binding on human whole cells |
J Med Chem 36: 3308-20 (1993)
BindingDB Entry DOI: 10.7270/Q21R6R4P |
More data for this Ligand-Target Pair | |
RAC-alpha serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50316182
(4-(2-(4-amino-1,2,5-oxadiazol-3-yl)-6-((S)-2-amino...)Show SMILES CCn1c(nc2c(nc(O[C@H](CN)c3ccccc3)cc12)C#CC(C)(C)O)-c1nonc1N |r| Show InChI InChI=1S/C23H25N7O3/c1-4-30-16-12-18(32-17(13-24)14-8-6-5-7-9-14)26-15(10-11-23(2,3)31)19(16)27-22(30)20-21(25)29-33-28-20/h5-9,12,17,31H,4,13,24H2,1-3H3,(H2,25,29)/t17-/m1/s1 | PDB
UniProtKB/SwissProt
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| 3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Inhibition of AKT |
Bioorg Med Chem Lett 19: 1508-11 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.002 BindingDB Entry DOI: 10.7270/Q2XK8FP7 |
More data for this Ligand-Target Pair | |
RAC-beta serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM25013
(4-[2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-[(3S...)Show SMILES CCn1c(nc2c(ncc(OC[C@H]3CCCNC3)c12)C#CC(C)(C)O)-c1nonc1N |r| Show InChI InChI=1S/C21H27N7O3/c1-4-28-18-15(30-12-13-6-5-9-23-10-13)11-24-14(7-8-21(2,3)29)16(18)25-20(28)17-19(22)27-31-26-17/h11,13,23,29H,4-6,9-10,12H2,1-3H3,(H2,22,27)/t13-/m0/s1 | PDB
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| 4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Inhibition of AKT2 |
Bioorg Med Chem Lett 19: 1508-11 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.002 BindingDB Entry DOI: 10.7270/Q2XK8FP7 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
RAC-beta serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50316192
(4-(2-(4-amino-1,2,5-oxadiazol-3-yl)-6-((R)-2-amino...)Show SMILES CCn1c(nc2c(nc(O[C@@H](CN)c3ccccc3)cc12)C#CC(C)(C)O)-c1nonc1N |r| Show InChI InChI=1S/C23H25N7O3/c1-4-30-16-12-18(32-17(13-24)14-8-6-5-7-9-14)26-15(10-11-23(2,3)31)19(16)27-22(30)20-21(25)29-33-28-20/h5-9,12,17,31H,4,13,24H2,1-3H3,(H2,25,29)/t17-/m0/s1 | PDB
UniProtKB/SwissProt
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| 5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Inhibition of AKT2 |
Bioorg Med Chem Lett 19: 1508-11 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.002 BindingDB Entry DOI: 10.7270/Q2XK8FP7 |
More data for this Ligand-Target Pair | |
RAC-alpha serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50316189
(4-(2-(4-amino-1,2,5-oxadiazol-3-yl)-6-(2-aminoetho...)Show SMILES CCn1c(nc2c(nc(OCCN)cc12)C#CC(C)(C)O)-c1nonc1N Show InChI InChI=1S/C17H21N7O3/c1-4-24-11-9-12(26-8-7-18)20-10(5-6-17(2,3)25)13(11)21-16(24)14-15(19)23-27-22-14/h9,25H,4,7-8,18H2,1-3H3,(H2,19,23) | PDB
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| 6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Inhibition of AKT |
Bioorg Med Chem Lett 19: 1508-11 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.002 BindingDB Entry DOI: 10.7270/Q2XK8FP7 |
More data for this Ligand-Target Pair | |
Leukotriene B4 receptor 1
(Homo sapiens (Human)) | BDBM50042150
(CHEMBL326397 | Lithium; 3-{1-hydroxy-2-[7-(1-hydro...)Show SMILES CCCCCCCCC(O)c1ccc2ccc(CC(O)c3cccc(c3)C([O-])=O)nc2c1 Show InChI InChI=1S/C27H33NO4/c1-2-3-4-5-6-7-11-25(29)21-13-12-19-14-15-23(28-24(19)17-21)18-26(30)20-9-8-10-22(16-20)27(31)32/h8-10,12-17,25-26,29-30H,2-7,11,18H2,1H3,(H,31,32)/p-1 | PDB
UniProtKB/SwissProt
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| 10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals
Curated by ChEMBL
| Assay Description Inhibition of [3H]- LTB4 binding on human whole cells |
J Med Chem 36: 3308-20 (1993)
BindingDB Entry DOI: 10.7270/Q21R6R4P |
More data for this Ligand-Target Pair | |
Endothelin-1 receptor
(Homo sapiens (Human)) | BDBM50041616
((1S,2S,3R)-1-Benzo[1,3]dioxol-5-yl-3-(4-methoxy-ph...)Show SMILES CCCOc1ccc2[C@@H]([C@H]([C@@H](c2c1)c1ccc(OC)cc1)C(O)=O)c1ccc2OCOc2c1 Show InChI InChI=1S/C27H26O6/c1-3-12-31-19-9-10-20-21(14-19)24(16-4-7-18(30-2)8-5-16)26(27(28)29)25(20)17-6-11-22-23(13-17)33-15-32-22/h4-11,13-14,24-26H,3,12,15H2,1-2H3,(H,28,29)/t24-,25+,26+/m1/s1 | PDB
UniProtKB/SwissProt
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| 11.3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals
Curated by ChEMBL
| Assay Description Inhibition of [125I]-ET-1 binding to cloned human ET-A receptor |
J Med Chem 37: 1553-7 (1994)
BindingDB Entry DOI: 10.7270/Q2154G2V |
More data for this Ligand-Target Pair | |
Endothelin receptor type B
(Homo sapiens (Human)) | BDBM50041617
((1S,2R,3S)-1-Benzo[1,3]dioxol-5-yl-3-(2-carboxymet...)Show SMILES CCCOc1ccc2[C@@H]([C@H]([C@@H](c2c1)c1ccc(OC)cc1OCC(O)=O)C(O)=O)c1ccc2OCOc2c1 Show InChI InChI=1S/C29H28O9/c1-3-10-35-18-6-7-19-21(12-18)27(20-8-5-17(34-2)13-23(20)36-14-25(30)31)28(29(32)33)26(19)16-4-9-22-24(11-16)38-15-37-22/h4-9,11-13,26-28H,3,10,14-15H2,1-2H3,(H,30,31)(H,32,33)/t26-,27+,28+/m0/s1 | PDB
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| 14.7 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals
Curated by ChEMBL
| Assay Description Inhibition of [125I]-ET-1 binding to cloned human ET-B receptor |
J Med Chem 37: 1553-7 (1994)
BindingDB Entry DOI: 10.7270/Q2154G2V |
More data for this Ligand-Target Pair | |
Endothelin-1 receptor
(Homo sapiens (Human)) | BDBM50041622
((1S,2S,3R)-1-Benzo[1,3]dioxol-5-yl-5-hydroxy-3-(4-...)Show SMILES COc1ccc(cc1)[C@H]1[C@@H]([C@H](c2ccc(O)cc12)c1ccc2OCOc2c1)C(O)=O Show InChI InChI=1S/C24H20O6/c1-28-16-6-2-13(3-7-16)21-18-11-15(25)5-8-17(18)22(23(21)24(26)27)14-4-9-19-20(10-14)30-12-29-19/h2-11,21-23,25H,12H2,1H3,(H,26,27)/t21-,22+,23+/m1/s1 | PDB
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| 15 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals
Curated by ChEMBL
| Assay Description Inhibition of [125I]-ET-1 binding to cloned human ET-A receptor |
J Med Chem 37: 1553-7 (1994)
BindingDB Entry DOI: 10.7270/Q2154G2V |
More data for this Ligand-Target Pair | |
RAC-beta serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50316182
(4-(2-(4-amino-1,2,5-oxadiazol-3-yl)-6-((S)-2-amino...)Show SMILES CCn1c(nc2c(nc(O[C@H](CN)c3ccccc3)cc12)C#CC(C)(C)O)-c1nonc1N |r| Show InChI InChI=1S/C23H25N7O3/c1-4-30-16-12-18(32-17(13-24)14-8-6-5-7-9-14)26-15(10-11-23(2,3)31)19(16)27-22(30)20-21(25)29-33-28-20/h5-9,12,17,31H,4,13,24H2,1-3H3,(H2,25,29)/t17-/m1/s1 | PDB
UniProtKB/SwissProt
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| Article PubMed
| 17 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Inhibition of AKT2 |
Bioorg Med Chem Lett 19: 1508-11 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.002 BindingDB Entry DOI: 10.7270/Q2XK8FP7 |
More data for this Ligand-Target Pair | |
RAC-beta serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50316189
(4-(2-(4-amino-1,2,5-oxadiazol-3-yl)-6-(2-aminoetho...)Show SMILES CCn1c(nc2c(nc(OCCN)cc12)C#CC(C)(C)O)-c1nonc1N Show InChI InChI=1S/C17H21N7O3/c1-4-24-11-9-12(26-8-7-18)20-10(5-6-17(2,3)25)13(11)21-16(24)14-15(19)23-27-22-14/h9,25H,4,7-8,18H2,1-3H3,(H2,19,23) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 39 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Inhibition of AKT2 |
Bioorg Med Chem Lett 19: 1508-11 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.002 BindingDB Entry DOI: 10.7270/Q2XK8FP7 |
More data for this Ligand-Target Pair | |
Endothelin-1 receptor
(Homo sapiens (Human)) | BDBM50041618
((1R,2R,3S)-1-Benzo[1,3]dioxol-5-yl-3-(4-methoxy-ph...)Show SMILES COc1ccc(cc1)[C@@H]1[C@H]([C@@H](c2ccccc12)c1ccc2OCOc2c1)C(O)=O Show InChI InChI=1S/C24H20O5/c1-27-16-9-6-14(7-10-16)21-17-4-2-3-5-18(17)22(23(21)24(25)26)15-8-11-19-20(12-15)29-13-28-19/h2-12,21-23H,13H2,1H3,(H,25,26)/t21-,22+,23+/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| 43 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals
Curated by ChEMBL
| Assay Description Inhibition of [125I]-ET-1 binding to cloned human ET-A receptor |
J Med Chem 37: 1553-7 (1994)
BindingDB Entry DOI: 10.7270/Q2154G2V |
More data for this Ligand-Target Pair | |
Leukotriene B4 receptor 1
(Homo sapiens (Human)) | BDBM50368705
(CHEMBL1788228)Show SMILES CCCCCCCC[C@@H](O)c1ccc2ccc(CCc3cccc(c3)C([O-])=O)nc2c1 |r| Show InChI InChI=1S/C27H33NO3/c1-2-3-4-5-6-7-11-26(29)22-14-13-21-15-17-24(28-25(21)19-22)16-12-20-9-8-10-23(18-20)27(30)31/h8-10,13-15,17-19,26,29H,2-7,11-12,16H2,1H3,(H,30,31)/p-1/t26-/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| 50 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals
Curated by ChEMBL
| Assay Description Inhibition of [3H]- LTB4 binding on human whole cells |
J Med Chem 36: 3308-20 (1993)
BindingDB Entry DOI: 10.7270/Q21R6R4P |
More data for this Ligand-Target Pair | |
Leukotriene B4 receptor 1
(Homo sapiens (Human)) | BDBM50042148
(CHEMBL111811 | Lithium; 3-{1-hydroxy-2-[6-(3-hydro...)Show SMILES CCCCCCCCC(O)CCc1cccc(CC(O)c2cccc(c2)C([O-])=O)n1 Show InChI InChI=1S/C25H35NO4/c1-2-3-4-5-6-7-14-23(27)16-15-21-12-9-13-22(26-21)18-24(28)19-10-8-11-20(17-19)25(29)30/h8-13,17,23-24,27-28H,2-7,14-16,18H2,1H3,(H,29,30)/p-1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| PubMed
| 60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals
Curated by ChEMBL
| Assay Description Inhibition of [3H]- LTB4 binding on human whole cells |
J Med Chem 36: 3308-20 (1993)
BindingDB Entry DOI: 10.7270/Q21R6R4P |
More data for this Ligand-Target Pair | |
Leukotriene B4 receptor 1
(Homo sapiens (Human)) | BDBM50042142
((R)-Lithium; 3-{2-[7-(1-hydroxy-nonyl)-quinolin-2-...)Show SMILES CCCCCCCCC(O)c1ccc2ccc(CCc3cccc(c3)C([O-])=O)nc2c1 Show InChI InChI=1S/C27H33NO3/c1-2-3-4-5-6-7-11-26(29)22-14-13-21-15-17-24(28-25(21)19-22)16-12-20-9-8-10-23(18-20)27(30)31/h8-10,13-15,17-19,26,29H,2-7,11-12,16H2,1H3,(H,30,31)/p-1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| 100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals
Curated by ChEMBL
| Assay Description Inhibition of [3H]- LTB4 binding on human whole cells |
J Med Chem 36: 3308-20 (1993)
BindingDB Entry DOI: 10.7270/Q21R6R4P |
More data for this Ligand-Target Pair | |
RAC-beta serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50316185
(4-(2-(4-amino-1,2,5-oxadiazol-3-yl)-6-((R)-3-amino...)Show SMILES CCn1c(nc2c(nc(O[C@H](CCN)c3ccccc3)cc12)C#CC(C)(C)O)-c1nonc1N |r| Show InChI InChI=1S/C24H27N7O3/c1-4-31-17-14-19(33-18(11-13-25)15-8-6-5-7-9-15)27-16(10-12-24(2,3)32)20(17)28-23(31)21-22(26)30-34-29-21/h5-9,14,18,32H,4,11,13,25H2,1-3H3,(H2,26,30)/t18-/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 105 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Inhibition of AKT2 |
Bioorg Med Chem Lett 19: 1508-11 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.002 BindingDB Entry DOI: 10.7270/Q2XK8FP7 |
More data for this Ligand-Target Pair | |
RAC-alpha serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50316197
(4-(2-(4-amino-1,2,5-oxadiazol-3-yl)-6-(3-aminoprop...)Show SMILES CCn1c(nc2c(nc(OCCCN)cc12)C#CC(C)(C)O)-c1nonc1N Show InChI InChI=1S/C18H23N7O3/c1-4-25-12-10-13(27-9-5-8-19)21-11(6-7-18(2,3)26)14(12)22-17(25)15-16(20)24-28-23-15/h10,26H,4-5,8-9,19H2,1-3H3,(H2,20,24) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 115 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Inhibition of AKT |
Bioorg Med Chem Lett 19: 1508-11 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.002 BindingDB Entry DOI: 10.7270/Q2XK8FP7 |
More data for this Ligand-Target Pair | |
Leukotriene B4 receptor 1
(Homo sapiens (Human)) | BDBM50042143
(3-[7-(1-Hydroxy-nonyl)-quinolin-2-ylmethanesulfiny...)Show SMILES CCCCCCCCC(O)c1ccc2ccc(CS(=O)c3cccc(c3)C(O)=O)nc2c1 Show InChI InChI=1S/C26H31NO4S/c1-2-3-4-5-6-7-11-25(28)20-13-12-19-14-15-22(27-24(19)17-20)18-32(31)23-10-8-9-21(16-23)26(29)30/h8-10,12-17,25,28H,2-7,11,18H2,1H3,(H,29,30) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| 140 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals
Curated by ChEMBL
| Assay Description Inhibition of [3H]- LTB4 binding on human whole cells |
J Med Chem 36: 3308-20 (1993)
BindingDB Entry DOI: 10.7270/Q21R6R4P |
More data for this Ligand-Target Pair | |
Endothelin-1 receptor
(Homo sapiens (Human)) | BDBM50041621
((1R,2R,3S)-1,3-Bis-(4-methoxy-phenyl)-indan-2-carb...)Show SMILES COc1ccc(cc1)[C@H]1[C@@H]([C@H](c2ccccc12)c1ccc(OC)cc1)C(O)=O Show InChI InChI=1S/C24H22O4/c1-27-17-11-7-15(8-12-17)21-19-5-3-4-6-20(19)22(23(21)24(25)26)16-9-13-18(28-2)14-10-16/h3-14,21-23H,1-2H3,(H,25,26)/t21-,22+,23+ | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| 422 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals
Curated by ChEMBL
| Assay Description Inhibition of [125I]-ET-1 binding to cloned human ET-A receptor |
J Med Chem 37: 1553-7 (1994)
BindingDB Entry DOI: 10.7270/Q2154G2V |
More data for this Ligand-Target Pair | |
Endothelin receptor type B
(Homo sapiens (Human)) | BDBM50041622
((1S,2S,3R)-1-Benzo[1,3]dioxol-5-yl-5-hydroxy-3-(4-...)Show SMILES COc1ccc(cc1)[C@H]1[C@@H]([C@H](c2ccc(O)cc12)c1ccc2OCOc2c1)C(O)=O Show InChI InChI=1S/C24H20O6/c1-28-16-6-2-13(3-7-16)21-18-11-15(25)5-8-17(18)22(23(21)24(26)27)14-4-9-19-20(10-14)30-12-29-19/h2-11,21-23,25H,12H2,1H3,(H,26,27)/t21-,22+,23+/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| 483 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals
Curated by ChEMBL
| Assay Description Inhibition of [125I]-ET-1 binding to cloned human ET-B receptor |
J Med Chem 37: 1553-7 (1994)
BindingDB Entry DOI: 10.7270/Q2154G2V |
More data for this Ligand-Target Pair | |
Leukotriene B4 receptor 1
(Homo sapiens (Human)) | BDBM50042151
(CHEMBL115826 | Lithium; 3-[7-(1-hydroxy-nonyl)-nap...)Show SMILES CCCCCCCCC(O)c1ccc2ccc(CS(=O)c3cccc(c3)C([O-])=O)cc2c1 Show InChI InChI=1S/C27H32O4S/c1-2-3-4-5-6-7-11-26(28)22-15-14-21-13-12-20(16-24(21)17-22)19-32(31)25-10-8-9-23(18-25)27(29)30/h8-10,12-18,26,28H,2-7,11,19H2,1H3,(H,29,30)/p-1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| 500 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals
Curated by ChEMBL
| Assay Description Inhibition of [3H]- LTB4 binding on human whole cells |
J Med Chem 36: 3308-20 (1993)
BindingDB Entry DOI: 10.7270/Q21R6R4P |
More data for this Ligand-Target Pair | |
Leukotriene B4 receptor 1
(Homo sapiens (Human)) | BDBM50042146
(3-[7-(1-Hydroxy-nonyl)-quinolin-2-ylmethylsulfanyl...)Show SMILES CCCCCCCCC(O)c1ccc2ccc(CSc3cccc(c3)C(O)=O)nc2c1 Show InChI InChI=1S/C26H31NO3S/c1-2-3-4-5-6-7-11-25(28)20-13-12-19-14-15-22(27-24(19)17-20)18-31-23-10-8-9-21(16-23)26(29)30/h8-10,12-17,25,28H,2-7,11,18H2,1H3,(H,29,30) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| 600 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals
Curated by ChEMBL
| Assay Description Inhibition of [3H]- LTB4 binding on human whole cells |
J Med Chem 36: 3308-20 (1993)
BindingDB Entry DOI: 10.7270/Q21R6R4P |
More data for this Ligand-Target Pair | |
RAC-beta serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50316197
(4-(2-(4-amino-1,2,5-oxadiazol-3-yl)-6-(3-aminoprop...)Show SMILES CCn1c(nc2c(nc(OCCCN)cc12)C#CC(C)(C)O)-c1nonc1N Show InChI InChI=1S/C18H23N7O3/c1-4-25-12-10-13(27-9-5-8-19)21-11(6-7-18(2,3)26)14(12)22-17(25)15-16(20)24-28-23-15/h10,26H,4-5,8-9,19H2,1-3H3,(H2,20,24) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 646 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Inhibition of AKT2 |
Bioorg Med Chem Lett 19: 1508-11 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.002 BindingDB Entry DOI: 10.7270/Q2XK8FP7 |
More data for this Ligand-Target Pair | |
Leukotriene B4 receptor 1
(Homo sapiens (Human)) | BDBM79408
((5R)-6-[6-[(1E,3S,5Z)-3-hydroxyundeca-1,5-dienyl]-...)Show SMILES CCCCC\C=C/C[C@H](O)\C=C\c1cccc(C[C@H](O)CCCCO)n1 Show InChI InChI=1S/C22H35NO3/c1-2-3-4-5-6-7-13-21(25)16-15-19-11-10-12-20(23-19)18-22(26)14-8-9-17-24/h6-7,10-12,15-16,21-22,24-26H,2-5,8-9,13-14,17-18H2,1H3/b7-6-,16-15+/t21-,22+/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| Purchase
PC cid PC sid UniChem
Similars
| PubMed
| 700 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals
Curated by ChEMBL
| Assay Description Inhibition of [3H]- LTB4 binding on human whole cells |
J Med Chem 36: 3308-20 (1993)
BindingDB Entry DOI: 10.7270/Q21R6R4P |
More data for this Ligand-Target Pair | |
Endothelin receptor type B
(Homo sapiens (Human)) | BDBM50041618
((1R,2R,3S)-1-Benzo[1,3]dioxol-5-yl-3-(4-methoxy-ph...)Show SMILES COc1ccc(cc1)[C@@H]1[C@H]([C@@H](c2ccccc12)c1ccc2OCOc2c1)C(O)=O Show InChI InChI=1S/C24H20O5/c1-27-16-9-6-14(7-10-16)21-17-4-2-3-5-18(17)22(23(21)24(25)26)15-8-11-19-20(12-15)29-13-28-19/h2-12,21-23H,13H2,1H3,(H,25,26)/t21-,22+,23+/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| 757 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals
Curated by ChEMBL
| Assay Description Inhibition of [125I]-ET-1 binding to cloned human ET-B receptor |
J Med Chem 37: 1553-7 (1994)
BindingDB Entry DOI: 10.7270/Q2154G2V |
More data for this Ligand-Target Pair | |
Leukotriene B4 receptor 1
(Homo sapiens (Human)) | BDBM50042145
(5-Hydroxy-6-[7-(1-hydroxy-nonyl)-quinolin-2-yl]-he...)Show InChI InChI=1S/C24H35NO4/c1-2-3-4-5-6-7-10-23(27)19-13-12-18-14-15-20(25-22(18)16-19)17-21(26)9-8-11-24(28)29/h12-16,21,23,26-27H,2-11,17H2,1H3,(H,28,29) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| 900 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals
Curated by ChEMBL
| Assay Description Inhibition of [3H]- LTB4 binding on human whole cells |
J Med Chem 36: 3308-20 (1993)
BindingDB Entry DOI: 10.7270/Q21R6R4P |
More data for this Ligand-Target Pair | |
Leukotriene B4 receptor 1
(Homo sapiens (Human)) | BDBM50042152
(CHEMBL114454 | Lithium; 3-(2-{6-[3-(3-butoxy-pheny...)Show SMILES CCCCOc1cccc(c1)C(O)CCc1cccc(CC(O)c2cccc(c2)C([O-])=O)n1 Show InChI InChI=1S/C27H31NO5/c1-2-3-15-33-24-12-5-8-20(17-24)25(29)14-13-22-10-6-11-23(28-22)18-26(30)19-7-4-9-21(16-19)27(31)32/h4-12,16-17,25-26,29-30H,2-3,13-15,18H2,1H3,(H,31,32)/p-1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| PubMed
| 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals
Curated by ChEMBL
| Assay Description Inhibition of [3H]- LTB4 binding on human whole cells |
J Med Chem 36: 3308-20 (1993)
BindingDB Entry DOI: 10.7270/Q21R6R4P |
More data for this Ligand-Target Pair | |
Endothelin receptor type B
(Homo sapiens (Human)) | BDBM50041616
((1S,2S,3R)-1-Benzo[1,3]dioxol-5-yl-3-(4-methoxy-ph...)Show SMILES CCCOc1ccc2[C@@H]([C@H]([C@@H](c2c1)c1ccc(OC)cc1)C(O)=O)c1ccc2OCOc2c1 Show InChI InChI=1S/C27H26O6/c1-3-12-31-19-9-10-20-21(14-19)24(16-4-7-18(30-2)8-5-16)26(27(28)29)25(20)17-6-11-22-23(13-17)33-15-32-22/h4-11,13-14,24-26H,3,12,15H2,1-2H3,(H,28,29)/t24-,25+,26+/m1/s1 | PDB
UniProtKB/SwissProt
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Similars
| PubMed
| 1.04E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals
Curated by ChEMBL
| Assay Description Inhibition of [125I]-ET-1 binding to cloned human ET-B receptor |
J Med Chem 37: 1553-7 (1994)
BindingDB Entry DOI: 10.7270/Q2154G2V |
More data for this Ligand-Target Pair | |
Leukotriene B4 receptor 1
(Homo sapiens (Human)) | BDBM50042141
(6-[7-(1-Hydroxy-nonyl)-quinolin-2-yl]-hex-5-enoic ...)Show InChI InChI=1S/C24H33NO3/c1-2-3-4-5-6-9-12-23(26)20-15-14-19-16-17-21(25-22(19)18-20)11-8-7-10-13-24(27)28/h8,11,14-18,23,26H,2-7,9-10,12-13H2,1H3,(H,27,28)/b11-8+ | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| PubMed
| 1.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals
Curated by ChEMBL
| Assay Description Inhibition of [3H]- LTB4 binding on human whole cells |
J Med Chem 36: 3308-20 (1993)
BindingDB Entry DOI: 10.7270/Q21R6R4P |
More data for this Ligand-Target Pair | |
Endothelin receptor type B
(Homo sapiens (Human)) | BDBM50041621
((1R,2R,3S)-1,3-Bis-(4-methoxy-phenyl)-indan-2-carb...)Show SMILES COc1ccc(cc1)[C@H]1[C@@H]([C@H](c2ccccc12)c1ccc(OC)cc1)C(O)=O Show InChI InChI=1S/C24H22O4/c1-27-17-11-7-15(8-12-17)21-19-5-3-4-6-20(19)22(23(21)24(25)26)16-9-13-18(28-2)14-10-16/h3-14,21-23H,1-2H3,(H,25,26)/t21-,22+,23+ | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| 2.44E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals
Curated by ChEMBL
| Assay Description Inhibition of [125I]-ET-1 binding to cloned human ET-B receptor |
J Med Chem 37: 1553-7 (1994)
BindingDB Entry DOI: 10.7270/Q2154G2V |
More data for this Ligand-Target Pair | |
Leukotriene B4 receptor 1
(Homo sapiens (Human)) | BDBM50042154
(6-[7-(1-Hydroxy-nonyl)-quinolin-2-yl]-hexanoic aci...)Show InChI InChI=1S/C24H35NO3/c1-2-3-4-5-6-9-12-23(26)20-15-14-19-16-17-21(25-22(19)18-20)11-8-7-10-13-24(27)28/h14-18,23,26H,2-13H2,1H3,(H,27,28) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| 2.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals
Curated by ChEMBL
| Assay Description Inhibition of [3H]- LTB4 binding on human whole cells |
J Med Chem 36: 3308-20 (1993)
BindingDB Entry DOI: 10.7270/Q21R6R4P |
More data for this Ligand-Target Pair | |
Endothelin-1 receptor
(Homo sapiens (Human)) | BDBM50041619
((1S,2S,3R)-1-(4-Methoxy-phenyl)-3-phenyl-indan-2-c...)Show SMILES COc1ccc(cc1)[C@@H]1[C@H]([C@@H](c2ccccc12)c1ccccc1)C(O)=O Show InChI InChI=1S/C23H20O3/c1-26-17-13-11-16(12-14-17)21-19-10-6-5-9-18(19)20(22(21)23(24)25)15-7-3-2-4-8-15/h2-14,20-22H,1H3,(H,24,25)/t20-,21+,22+/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| 5.67E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals
Curated by ChEMBL
| Assay Description Inhibition of [125I]-ET-1 binding to cloned human Endothelin A receptor |
J Med Chem 37: 1553-7 (1994)
BindingDB Entry DOI: 10.7270/Q2154G2V |
More data for this Ligand-Target Pair | |
Leukotriene B4 receptor 1
(Homo sapiens (Human)) | BDBM50042147
(CHEMBL113401 | Lithium; 3-[7-(1-hydroxy-nonyl)-nap...)Show SMILES CCCCCCCCC(O)c1ccc2ccc(CSc3cccc(c3)C([O-])=O)cc2c1 Show InChI InChI=1S/C27H32O3S/c1-2-3-4-5-6-7-11-26(28)22-15-14-21-13-12-20(16-24(21)17-22)19-31-25-10-8-9-23(18-25)27(29)30/h8-10,12-18,26,28H,2-7,11,19H2,1H3,(H,29,30)/p-1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| 9.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals
Curated by ChEMBL
| Assay Description Inhibition of [3H]- LTB4 binding on human whole cells |
J Med Chem 36: 3308-20 (1993)
BindingDB Entry DOI: 10.7270/Q21R6R4P |
More data for this Ligand-Target Pair | |
Endothelin-1 receptor
(Homo sapiens (Human)) | BDBM50041620
((1R,2R,3S)-1,3-Diphenyl-indan-2-carboxylic acid | ...)Show SMILES OC(=O)[C@H]1[C@@H](c2ccccc2[C@@H]1c1ccccc1)c1ccccc1 Show InChI InChI=1S/C22H18O2/c23-22(24)21-19(15-9-3-1-4-10-15)17-13-7-8-14-18(17)20(21)16-11-5-2-6-12-16/h1-14,19-21H,(H,23,24)/t19-,20+,21+ | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| 1.12E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals
Curated by ChEMBL
| Assay Description Inhibition of [125I]-ET-1 binding to cloned human ET-A receptor |
J Med Chem 37: 1553-7 (1994)
BindingDB Entry DOI: 10.7270/Q2154G2V |
More data for this Ligand-Target Pair | |
Endothelin receptor type B
(Homo sapiens (Human)) | BDBM50041620
((1R,2R,3S)-1,3-Diphenyl-indan-2-carboxylic acid | ...)Show SMILES OC(=O)[C@H]1[C@@H](c2ccccc2[C@@H]1c1ccccc1)c1ccccc1 Show InChI InChI=1S/C22H18O2/c23-22(24)21-19(15-9-3-1-4-10-15)17-13-7-8-14-18(17)20(21)16-11-5-2-6-12-16/h1-14,19-21H,(H,23,24)/t19-,20+,21+ | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals
Curated by ChEMBL
| Assay Description Inhibition of [125I]-ET-1 binding to cloned human ET-B receptor |
J Med Chem 37: 1553-7 (1994)
BindingDB Entry DOI: 10.7270/Q2154G2V |
More data for this Ligand-Target Pair | |
Endothelin receptor type B
(Homo sapiens (Human)) | BDBM50041619
((1S,2S,3R)-1-(4-Methoxy-phenyl)-3-phenyl-indan-2-c...)Show SMILES COc1ccc(cc1)[C@@H]1[C@H]([C@@H](c2ccccc12)c1ccccc1)C(O)=O Show InChI InChI=1S/C23H20O3/c1-26-17-13-11-16(12-14-17)21-19-10-6-5-9-18(19)20(22(21)23(24)25)15-7-3-2-4-8-15/h2-14,20-22H,1H3,(H,24,25)/t20-,21+,22+/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals
Curated by ChEMBL
| Assay Description Inhibition of [125I]-ET-1 binding to cloned human ET-B receptor |
J Med Chem 37: 1553-7 (1994)
BindingDB Entry DOI: 10.7270/Q2154G2V |
More data for this Ligand-Target Pair | |
RAC-alpha serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50316183
(4-(2-(4-amino-1,2,5-oxadiazol-3-yl)-6-((R)-2-amino...)Show SMILES CCn1c(nc2c(nc(OC[C@H](N)Cc3ccccc3)cc12)C#CC(C)(C)O)-c1nonc1N |r| Show InChI InChI=1S/C24H27N7O3/c1-4-31-18-13-19(33-14-16(25)12-15-8-6-5-7-9-15)27-17(10-11-24(2,3)32)20(18)28-23(31)21-22(26)30-34-29-21/h5-9,13,16,32H,4,12,14,25H2,1-3H3,(H2,26,30)/t16-/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL MMDB PC cid PC sid PDB UniChem
Similars
| PDB Article PubMed
| n/a | n/a | 0.600 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Inhibition of AKT |
Bioorg Med Chem Lett 19: 1508-11 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.002 BindingDB Entry DOI: 10.7270/Q2XK8FP7 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Ribosomal protein S6 kinase alpha-5
(Homo sapiens (Human)) | BDBM24994
(4-[1-ethyl-7-(piperidin-4-ylmethoxy)-1H-imidazo[4,...)Show InChI InChI=1S/C16H21N7O2/c1-2-23-14-11(20-16(23)13-15(17)22-25-21-13)7-19-8-12(14)24-9-10-3-5-18-6-4-10/h7-8,10,18H,2-6,9H2,1H3,(H2,17,22) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
| Assay Description IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from radiolabeled AT... |
J Med Chem 51: 5663-79 (2008)
Article DOI: 10.1021/jm8004527 BindingDB Entry DOI: 10.7270/Q29G5K3H |
More data for this Ligand-Target Pair | |
Ribosomal protein S6 kinase alpha-1
(Homo sapiens (Human)) | BDBM25004
(3-[2-(4-amino-1,2,5-oxadiazol-3-yl)-7-(3-aminoprop...)Show InChI InChI=1S/C16H19N7O3/c1-2-23-14-11(25-8-4-6-17)9-19-10(5-3-7-24)12(14)20-16(23)13-15(18)22-26-21-13/h9,24H,2,4,6-8,17H2,1H3,(H2,18,22) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
MCE PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
| Assay Description IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from radiolabeled AT... |
J Med Chem 51: 5663-79 (2008)
Article DOI: 10.1021/jm8004527 BindingDB Entry DOI: 10.7270/Q29G5K3H |
More data for this Ligand-Target Pair | |
RAC-gamma serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50316192
(4-(2-(4-amino-1,2,5-oxadiazol-3-yl)-6-((R)-2-amino...)Show SMILES CCn1c(nc2c(nc(O[C@@H](CN)c3ccccc3)cc12)C#CC(C)(C)O)-c1nonc1N |r| Show InChI InChI=1S/C23H25N7O3/c1-4-30-16-12-18(32-17(13-24)14-8-6-5-7-9-14)26-15(10-11-23(2,3)31)19(16)27-22(30)20-21(25)29-33-28-20/h5-9,12,17,31H,4,13,24H2,1-3H3,(H2,25,29)/t17-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Inhibition of AKT3 |
Bioorg Med Chem Lett 19: 1508-11 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.002 BindingDB Entry DOI: 10.7270/Q2XK8FP7 |
More data for this Ligand-Target Pair | |
Rho-associated protein kinase 1
(Homo sapiens (Human)) | BDBM14043
(Aminofurazanyl-azabenzimidazole 6j | N-(3-{[2-(4-a...)Show SMILES CCn1c(nc2cnc(Oc3cccc(NC(=O)c4ccc(CN)cc4)c3)cc12)-c1nonc1N Show InChI InChI=1S/C24H22N8O3/c1-2-32-19-11-20(27-13-18(19)29-23(32)21-22(26)31-35-30-21)34-17-5-3-4-16(10-17)28-24(33)15-8-6-14(12-25)7-9-15/h3-11,13H,2,12,25H2,1H3,(H2,26,31)(H,28,33) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | <1 | n/a | n/a | n/a | n/a | 7.4 | 22 |
GlaxoSmithKline
| Assay Description The assay of Rock-1 activity involved incubation with peptide substrate and ATP/[gamma-33P] ATP, the subsequent incorporation of 33P into the peptid... |
J Med Chem 50: 2-5 (2007)
Article DOI: 10.1021/jm060873p BindingDB Entry DOI: 10.7270/Q2F18WZB |
More data for this Ligand-Target Pair | |