Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Protein O-GlcNAcase (Homo sapiens (Human)) | BDBM139926 (US8901087, 2) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | 0.0500 | -58.8 | n/a | n/a | n/a | n/a | n/a | 7.0 | 25 |
Merck Sharp & Dohme Corp. US Patent | Assay Description Enzymatic reactions are carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acety... | US Patent US8901087 (2014) BindingDB Entry DOI: 10.7270/Q24B301W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(3) dopamine receptor (Homo sapiens (Human)) | BDBM50443101 (Cariprazine | RGH-188) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase DrugBank MCE PC cid PC sid PDB UniChem Similars | Article PubMed | 0.0850 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. Curated by ChEMBL | Assay Description Displacement of [3H]Spiperone from dopamine D3 receptor (unknown origin) | J Med Chem 60: 6480-6515 (2017) Article DOI: 10.1021/acs.jmedchem.7b00010 BindingDB Entry DOI: 10.7270/Q2PK0JDP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human)) | BDBM466723 (US10800761, Example 42 | US10800761, Example 55 | ...) | PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | <0.100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Assay Description In vitro inhibition of human carbonic anhydrase II (0.1 nM). | Citation and Details | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Indoleamine 2,3-dioxygenase 1 (Homo sapiens (Human)) | BDBM50604026 (CHEMBL5192384) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | 0.110 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01670 BindingDB Entry DOI: 10.7270/Q2VH5SX2 | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor (Homo sapiens (Human)) | BDBM4779 (CHEMBL31965 | CHEMBL545315 | CI-1033 | Canertinib ...) | PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 0.110 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. Curated by ChEMBL | Assay Description Reversible binding affinity to human EGFR L858R/ T790M double mutant expressed in baculovirus by fluorometric analysis | J Med Chem 59: 2005-24 (2016) Article DOI: 10.1021/acs.jmedchem.5b01633 BindingDB Entry DOI: 10.7270/Q2KS6TDD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (Homo sapiens (Human)) | BDBM50428107 (CHEMBL2331664 | PF-04979064 | US8791131, 257) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Similars | PDB Article PubMed | 0.111 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. Curated by ChEMBL | Assay Description Inhibition of human PI3Kgamma | ACS Med Chem Lett 4: 91-7 (2013) Article DOI: 10.1021/ml300309h BindingDB Entry DOI: 10.7270/Q2HX1F0B | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Protein O-GlcNAcase (Homo sapiens (Human)) | BDBM139933 (US8901087, 27) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | 0.120 | -56.6 | n/a | n/a | n/a | n/a | n/a | 7.0 | 25 |
Merck Sharp & Dohme Corp. US Patent | Assay Description Enzymatic reactions are carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acety... | US Patent US8901087 (2014) BindingDB Entry DOI: 10.7270/Q24B301W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human)) | BDBM50428107 (CHEMBL2331664 | PF-04979064 | US8791131, 257) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Similars | Article PubMed | 0.122 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. Curated by ChEMBL | Assay Description Inhibition of human PI3Kdelta | ACS Med Chem Lett 4: 91-7 (2013) Article DOI: 10.1021/ml300309h BindingDB Entry DOI: 10.7270/Q2HX1F0B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein O-GlcNAcase (Homo sapiens (Human)) | BDBM177755 (US9120781, 18) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | 0.130 | -56.4 | n/a | n/a | n/a | n/a | n/a | 7.0 | 25 |
Simon Fraser University; Merck Sharp & Dohme Corp.; Alectos Therapeutics Inc. US Patent | Assay Description Enzymatic reactions are carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acety... | US Patent US9120781 (2015) BindingDB Entry DOI: 10.7270/Q2DZ072S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human)) | BDBM50428107 (CHEMBL2331664 | PF-04979064 | US8791131, 257) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Similars | Article PubMed | 0.130 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. Curated by ChEMBL | Assay Description Inhibition of human PI3Kalpha | ACS Med Chem Lett 4: 91-7 (2013) Article DOI: 10.1021/ml300309h BindingDB Entry DOI: 10.7270/Q2HX1F0B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein O-GlcNAcase (Homo sapiens (Human)) | BDBM179374 (US9126957, 10) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | 0.140 | -56.2 | n/a | n/a | n/a | n/a | n/a | 7.0 | 25 |
MERCK SHARP & DOHME CORP.; ALECTOS THERAPEUTICS, INC. US Patent | Assay Description Enzymatic reactions are carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acety... | US Patent US9126957 (2015) BindingDB Entry DOI: 10.7270/Q2DV1HN2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein O-GlcNAcase (Homo sapiens (Human)) | BDBM139959 (US8901087, 191) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | 0.140 | -56.2 | n/a | n/a | n/a | n/a | n/a | 7.0 | 25 |
Merck Sharp & Dohme Corp. US Patent | Assay Description Enzymatic reactions are carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acety... | US Patent US8901087 (2014) BindingDB Entry DOI: 10.7270/Q24B301W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Indoleamine 2,3-dioxygenase 1 (Homo sapiens (Human)) | BDBM50604023 (CHEMBL5192977) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem | PDB Article PubMed | 0.150 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01670 BindingDB Entry DOI: 10.7270/Q2VH5SX2 | ||||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Protein O-GlcNAcase (Homo sapiens (Human)) | BDBM139951 (US8901087, 95) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | 0.160 | -55.9 | n/a | n/a | n/a | n/a | n/a | 7.0 | 25 |
Merck Sharp & Dohme Corp. US Patent | Assay Description Enzymatic reactions are carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acety... | US Patent US8901087 (2014) BindingDB Entry DOI: 10.7270/Q24B301W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein O-GlcNAcase (Homo sapiens (Human)) | BDBM314813 ((3aR,5S,6S,7R,7aR)-5-((R)-1-(4- benzylbenzyloxy)-2...) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.160 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
ALECTOS THERAPEUTICS, INC.; MERCK SHARP & DOHME CORP. US Patent | Assay Description Enzymatic reactions were carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acet... | US Patent US9611275 (2017) BindingDB Entry DOI: 10.7270/Q2833V4D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein O-GlcNAcase (Homo sapiens (Human)) | BDBM139925 (US8901087, 1) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | 0.170 | -55.8 | n/a | n/a | n/a | n/a | n/a | 7.0 | 25 |
Merck Sharp & Dohme Corp. US Patent | Assay Description Enzymatic reactions are carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acety... | US Patent US8901087 (2014) BindingDB Entry DOI: 10.7270/Q24B301W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein O-GlcNAcase (Homo sapiens (Human)) | BDBM139952 (US8901087, 97) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | 0.170 | -55.8 | n/a | n/a | n/a | n/a | n/a | 7.0 | 25 |
Merck Sharp & Dohme Corp. US Patent | Assay Description Enzymatic reactions are carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acety... | US Patent US8901087 (2014) BindingDB Entry DOI: 10.7270/Q24B301W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein O-GlcNAcase (Homo sapiens (Human)) | BDBM139946 (US8901087, 76) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | 0.180 | -55.6 | n/a | n/a | n/a | n/a | n/a | 7.0 | 25 |
Merck Sharp & Dohme Corp. US Patent | Assay Description Enzymatic reactions are carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acety... | US Patent US8901087 (2014) BindingDB Entry DOI: 10.7270/Q24B301W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein O-GlcNAcase (Homo sapiens (Human)) | BDBM46008 (US8901087, 96) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | 0.190 | -55.5 | n/a | n/a | n/a | n/a | n/a | 7.0 | 25 |
Merck Sharp & Dohme Corp. US Patent | Assay Description Enzymatic reactions are carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acety... | US Patent US8901087 (2014) BindingDB Entry DOI: 10.7270/Q24B301W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein O-GlcNAcase (Homo sapiens (Human)) | BDBM314809 ((3aR,5S,6S,7R,7aR)-2-(dimethylamino)-5-((R)-1-meth...) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.190 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
ALECTOS THERAPEUTICS, INC.; MERCK SHARP & DOHME CORP. US Patent | Assay Description Enzymatic reactions were carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acet... | US Patent US9611275 (2017) BindingDB Entry DOI: 10.7270/Q2833V4D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Mus musculus (Mouse)) | BDBM50428109 (CHEMBL2331668 | US8791131, 259) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.191 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. Curated by ChEMBL | Assay Description Inhibition of mouse PI3Kalpha | ACS Med Chem Lett 4: 91-7 (2013) Article DOI: 10.1021/ml300309h BindingDB Entry DOI: 10.7270/Q2HX1F0B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein O-GlcNAcase (Homo sapiens (Human)) | BDBM177758 (US9120781, 26) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | 0.200 | -55.4 | n/a | n/a | n/a | n/a | n/a | 7.0 | 25 |
Simon Fraser University; Merck Sharp & Dohme Corp.; Alectos Therapeutics Inc. US Patent | Assay Description Enzymatic reactions are carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acety... | US Patent US9120781 (2015) BindingDB Entry DOI: 10.7270/Q2DZ072S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein O-GlcNAcase (Homo sapiens (Human)) | BDBM139941 (US8901087, 63) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | 0.220 | -55.1 | n/a | n/a | n/a | n/a | n/a | 7.0 | 25 |
Merck Sharp & Dohme Corp. US Patent | Assay Description Enzymatic reactions are carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acety... | US Patent US8901087 (2014) BindingDB Entry DOI: 10.7270/Q24B301W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 6 (Homo sapiens (Human)) | BDBM50334730 (3-(Naphthalen-1-ylsulfonyl)-5-(piperazin-1-ylmethy...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.240 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research Curated by ChEMBL | Assay Description Displacement of [3H]-LSD from cloned human 5-HT6 receptor expressed in human HeLa cells | Bioorg Med Chem 19: 650-62 (2011) Article DOI: 10.1016/j.bmc.2010.10.033 BindingDB Entry DOI: 10.7270/Q29S1R9V | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase mTOR (Homo sapiens (Human)) | BDBM50428109 (CHEMBL2331668 | US8791131, 259) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.243 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. Curated by ChEMBL | Assay Description Inhibition of mTOR (unknown origin) | ACS Med Chem Lett 4: 91-7 (2013) Article DOI: 10.1021/ml300309h BindingDB Entry DOI: 10.7270/Q2HX1F0B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein O-GlcNAcase (Homo sapiens (Human)) | BDBM179366 (US9126957, 2) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | 0.260 | -54.7 | n/a | n/a | n/a | n/a | n/a | 7.0 | 25 |
MERCK SHARP & DOHME CORP.; ALECTOS THERAPEUTICS, INC. US Patent | Assay Description Enzymatic reactions are carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acety... | US Patent US9126957 (2015) BindingDB Entry DOI: 10.7270/Q2DV1HN2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein O-GlcNAcase (Homo sapiens (Human)) | BDBM179370 (US9126957, 6) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | 0.260 | -54.7 | n/a | n/a | n/a | n/a | n/a | 7.0 | 25 |
MERCK SHARP & DOHME CORP.; ALECTOS THERAPEUTICS, INC. US Patent | Assay Description Enzymatic reactions are carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acety... | US Patent US9126957 (2015) BindingDB Entry DOI: 10.7270/Q2DV1HN2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Mus musculus (Mouse)) | BDBM50428107 (CHEMBL2331664 | PF-04979064 | US8791131, 257) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Similars | Article PubMed | 0.299 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. Curated by ChEMBL | Assay Description Inhibition of mouse PI3Kalpha | ACS Med Chem Lett 4: 91-7 (2013) Article DOI: 10.1021/ml300309h BindingDB Entry DOI: 10.7270/Q2HX1F0B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human)) | BDBM50336407 (4-amino-2,6-dimethyl-N-(1H-pyrrolo[2,3-b]pyridin-5...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.300 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. Curated by ChEMBL | Assay Description Inhibition of PI3Kalpha by fluorescene polarization assay | Bioorg Med Chem Lett 21: 1270-4 (2011) Article DOI: 10.1016/j.bmcl.2010.12.026 BindingDB Entry DOI: 10.7270/Q2H1329M | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein O-GlcNAcase (Homo sapiens (Human)) | BDBM139930 (US8901087, 11) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | 0.300 | -54.4 | n/a | n/a | n/a | n/a | n/a | 7.0 | 25 |
Merck Sharp & Dohme Corp. US Patent | Assay Description Enzymatic reactions are carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acety... | US Patent US8901087 (2014) BindingDB Entry DOI: 10.7270/Q24B301W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein O-GlcNAcase (Homo sapiens (Human)) | BDBM139939 (US8901087, 57) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | 0.330 | -54.1 | n/a | n/a | n/a | n/a | n/a | 7.0 | 25 |
Merck Sharp & Dohme Corp. US Patent | Assay Description Enzymatic reactions are carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acety... | US Patent US8901087 (2014) BindingDB Entry DOI: 10.7270/Q24B301W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human)) | BDBM50380320 (CHEMBL2017653) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.350 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Inhibition of PI3Kalpha | ACS Med Chem Lett 2: 809-813 (2011) Article DOI: 10.1021/ml200126j BindingDB Entry DOI: 10.7270/Q2DJ5GN2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein O-GlcNAcase (Homo sapiens (Human)) | BDBM50513934 (CHEMBL4443587) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 0.360 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck & Co. Curated by ChEMBL | Assay Description Inhibition of recombinant human OGA | J Med Chem 62: 10062-10097 (2019) Article DOI: 10.1021/acs.jmedchem.9b01090 BindingDB Entry DOI: 10.7270/Q21G0QMH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase mTOR (Homo sapiens (Human)) | BDBM50428111 (CHEMBL2331666 | US8791131, 153) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.377 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. Curated by ChEMBL | Assay Description Inhibition of mTOR (unknown origin) | ACS Med Chem Lett 4: 91-7 (2013) Article DOI: 10.1021/ml300309h BindingDB Entry DOI: 10.7270/Q2HX1F0B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Mus musculus (Mouse)) | BDBM50428108 (CHEMBL2331669 | US8791131, 255) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.395 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. Curated by ChEMBL | Assay Description Inhibition of mouse PI3Kalpha | ACS Med Chem Lett 4: 91-7 (2013) Article DOI: 10.1021/ml300309h BindingDB Entry DOI: 10.7270/Q2HX1F0B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein O-GlcNAcase (Homo sapiens (Human)) | BDBM139931 (US8901087, 13) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | 0.400 | -53.6 | n/a | n/a | n/a | n/a | n/a | 7.0 | 25 |
Merck Sharp & Dohme Corp. US Patent | Assay Description Enzymatic reactions are carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acety... | US Patent US8901087 (2014) BindingDB Entry DOI: 10.7270/Q24B301W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein O-GlcNAcase (Homo sapiens (Human)) | BDBM50323697 ((3AR,5R,6S,7R,7AR)-2-(ETHYLAMINO)-5-(HYDROXYMETHYL...) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Similars | PDB Article PubMed | 0.410 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck & Co. Curated by ChEMBL | Assay Description Inhibition of recombinant human OGA | J Med Chem 62: 10062-10097 (2019) Article DOI: 10.1021/acs.jmedchem.9b01090 BindingDB Entry DOI: 10.7270/Q21G0QMH | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Protein O-GlcNAcase (Homo sapiens (Human)) | BDBM139961 (US8901087, 211) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | 0.440 | -53.4 | n/a | n/a | n/a | n/a | n/a | 7.0 | 25 |
Merck Sharp & Dohme Corp. US Patent | Assay Description Enzymatic reactions are carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acety... | US Patent US8901087 (2014) BindingDB Entry DOI: 10.7270/Q24B301W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein O-GlcNAcase (Homo sapiens (Human)) | BDBM139942 (US8901087, 65) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | 0.450 | -53.3 | n/a | n/a | n/a | n/a | n/a | 7.0 | 25 |
Merck Sharp & Dohme Corp. US Patent | Assay Description Enzymatic reactions are carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acety... | US Patent US8901087 (2014) BindingDB Entry DOI: 10.7270/Q24B301W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein O-GlcNAcase (Homo sapiens (Human)) | BDBM314781 ((3aR,5S,6S,7R,7aR)-2- (dimethylamino)-5-((R)-2,2,2...) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.450 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
ALECTOS THERAPEUTICS, INC.; MERCK SHARP & DOHME CORP. US Patent | Assay Description Enzymatic reactions were carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acet... | US Patent US9611275 (2017) BindingDB Entry DOI: 10.7270/Q2833V4D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (Homo sapiens (Human)) | BDBM50443101 (Cariprazine | RGH-188) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase DrugBank MCE PC cid PC sid PDB UniChem Similars | DrugBank Article PubMed | 0.490 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. Curated by ChEMBL | Assay Description Displacement of [3H]Spiperone from human dopamine D2L receptor expressed in CHO cells | J Med Chem 60: 6480-6515 (2017) Article DOI: 10.1021/acs.jmedchem.7b00010 BindingDB Entry DOI: 10.7270/Q2PK0JDP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human)) | BDBM50385670 (CHEMBL2042399) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.490 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Seoul National University Curated by ChEMBL | Assay Description Antagonist activity at human TRPV1 receptor expressed in CHO cells assessed as decrease in capsaicin-induced intracellular 45Ca2+ uptake after 1 hr b... | Bioorg Med Chem 20: 215-24 (2011) Article DOI: 10.1016/j.bmc.2011.11.008 BindingDB Entry DOI: 10.7270/Q2MG7QJJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human)) | BDBM50336406 (4-amino-2,6-dimethyl-N-(6-methylpyridin-3-yl)quina...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. Curated by ChEMBL | Assay Description Inhibition of PI3Kalpha by fluorescene polarization assay | Bioorg Med Chem Lett 21: 1270-4 (2011) Article DOI: 10.1016/j.bmcl.2010.12.026 BindingDB Entry DOI: 10.7270/Q2H1329M | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein O-GlcNAcase (Homo sapiens (Human)) | BDBM177756 (US9120781, 22) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | 0.5 | -53.1 | n/a | n/a | n/a | n/a | n/a | 7.0 | 25 |
Simon Fraser University; Merck Sharp & Dohme Corp.; Alectos Therapeutics Inc. US Patent | Assay Description Enzymatic reactions are carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acety... | US Patent US9120781 (2015) BindingDB Entry DOI: 10.7270/Q2DZ072S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 6 (Homo sapiens (Human)) | BDBM28574 (1-sulfonylindazole, 6c | 3-amino-N-[1-(naphthalene...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | 0.5 | -52.6 | n/a | n/a | n/a | n/a | n/a | 7.4 | 22 |
Wyeth Research | Assay Description Competition experiments were performed in the presence radioligand with membrane protein (obtained from cells expressing the receptor) and test compo... | Bioorg Med Chem Lett 19: 2413-5 (2009) Article DOI: 10.1016/j.bmcl.2009.03.071 BindingDB Entry DOI: 10.7270/Q28K77CF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein O-GlcNAcase (Homo sapiens (Human)) | BDBM139948 (US8901087, 80) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | 0.5 | -53.1 | n/a | n/a | n/a | n/a | n/a | 7.0 | 25 |
Merck Sharp & Dohme Corp. US Patent | Assay Description Enzymatic reactions are carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acety... | US Patent US8901087 (2014) BindingDB Entry DOI: 10.7270/Q24B301W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human)) | BDBM50336405 (4-amino-2-methyl-N-(6-methylpyridin-3-yl)quinazoli...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. Curated by ChEMBL | Assay Description Inhibition of PI3Kalpha by fluorescene polarization assay | Bioorg Med Chem Lett 21: 1270-4 (2011) Article DOI: 10.1016/j.bmcl.2010.12.026 BindingDB Entry DOI: 10.7270/Q2H1329M | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human)) | BDBM50336410 (4-amino-N-(6-methoxypyridin-3-yl)-2,6-dimethylquin...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. Curated by ChEMBL | Assay Description Inhibition of PI3Kalpha by fluorescene polarization assay | Bioorg Med Chem Lett 21: 1270-4 (2011) Article DOI: 10.1016/j.bmcl.2010.12.026 BindingDB Entry DOI: 10.7270/Q2H1329M | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein O-GlcNAcase (Homo sapiens (Human)) | BDBM50513931 (CHEMBL4444446) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 0.530 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck & Co. Curated by ChEMBL | Assay Description Inhibition of recombinant human OGA | J Med Chem 62: 10062-10097 (2019) Article DOI: 10.1021/acs.jmedchem.9b01090 BindingDB Entry DOI: 10.7270/Q21G0QMH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein O-GlcNAcase (Homo sapiens (Human)) | BDBM139950 (US8901087, 91) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | 0.530 | -52.9 | n/a | n/a | n/a | n/a | n/a | 7.0 | 25 |
Merck Sharp & Dohme Corp. US Patent | Assay Description Enzymatic reactions are carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acety... | US Patent US8901087 (2014) BindingDB Entry DOI: 10.7270/Q24B301W | |||||||||||
More data for this Ligand-Target Pair |
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