BindingDB PrimarySearch

Found 69 hits with Last Name = 'malmquist' and Initial = 'na'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human))	BDBM15339 (6-fluoro-2-[4-(2-fluorophenyl)phenyl]-3-methyl-qui...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	MMDB PDB Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Institut Pasteur Curated by ChEMBL					Assay Description Inhibition of human recombinant DHODH				J Med Chem 58: 5579-98 (2015) Article DOI: 10.1021/acs.jmedchem.5b00606 BindingDB Entry DOI: 10.7270/Q20V8FJT
Institut Pasteur Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Dihydroorotate dehydrogenase (quinone), mitochondrial (Plasmodium falciparum)	BDBM14711 (Asinex compound no. 6 \| N-(3,5-Dichlorophenyl)-2-m...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	Purchase PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	16	n/a	n/a	n/a	n/a	8.0	22
University of Texas Southwestern Medical Center					Assay Description The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...				J Biol Chem 280: 21847-53 (2005) Article DOI: 10.1074/jbc.M501100200 BindingDB Entry DOI: 10.7270/Q21G0JH3
University of Texas Southwestern Medical Center					More data for this Ligand-Target Pair				3D Structure (crystal)
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human))	BDBM50095120 (CHEMBL3589752) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	25	n/a	n/a	n/a	n/a	n/a	n/a
Institut Pasteur Curated by ChEMBL					Assay Description Inhibition of His-tagged human DHODH assessed as reduction of DCIP by spectrophotometry				J Med Chem 58: 5579-98 (2015) Article DOI: 10.1021/acs.jmedchem.5b00606 BindingDB Entry DOI: 10.7270/Q20V8FJT
Institut Pasteur Curated by ChEMBL					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Plasmodium falciparum (isolate 3D7))	BDBM24400 (5-methyl-N-(naphthalen-2-yl)-[1,2,4]triazolo[1,5-a...) Show SMILES Cc1cc(Nc2ccc3ccccc3c2)n2ncnc2n1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	47	n/a	n/a	n/a	n/a	8.0	20
University of Texas Southwestern Medical Center at Dallas					Assay Description The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...				J Med Chem 51: 3649-53 (2008) Article DOI: 10.1021/jm8001026 BindingDB Entry DOI: 10.7270/Q2PV6HNF
University of Texas Southwestern Medical Center at Dallas					More data for this Ligand-Target Pair				3D Structure (crystal)
Dihydroorotate dehydrogenase (quinone), mitochondrial (Plasmodium falciparum)	BDBM15345 (Asinex compound no. 1 \| N-(2,4-dichlorophenyl)naph...) Show SMILES Clc1ccc(NC(=O)c2ccc3ccccc3c2)c(Cl)c1 Show InChI	PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	50	n/a	n/a	n/a	n/a	8.0	22
University of Texas Southwestern Medical Center					Assay Description The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...				J Biol Chem 280: 21847-53 (2005) Article DOI: 10.1074/jbc.M501100200 BindingDB Entry DOI: 10.7270/Q21G0JH3
University of Texas Southwestern Medical Center					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Plasmodium falciparum)	BDBM14710 (ChemBridge compound no. 2 \| N-(4-Bromo-2-methylphe...) Show SMILES Cc1cc(Br)ccc1NC(=O)c1ccc2ccccc2c1 Show InChI	PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	50	n/a	n/a	n/a	n/a	8.0	22
University of Texas Southwestern Medical Center					Assay Description The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...				J Biol Chem 280: 21847-53 (2005) Article DOI: 10.1074/jbc.M501100200 BindingDB Entry DOI: 10.7270/Q21G0JH3
University of Texas Southwestern Medical Center					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial [R265A] (Plasmodium falciparum)	BDBM14710 (ChemBridge compound no. 2 \| N-(4-Bromo-2-methylphe...) Show SMILES Cc1cc(Br)ccc1NC(=O)c1ccc2ccccc2c1 Show InChI	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	50	n/a	n/a	n/a	n/a	n/a	n/a
University of Texas Southwestern Medical Center					Assay Description The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...				J Biol Chem 280: 21847-53 (2005) Article DOI: 10.1074/jbc.M501100200 BindingDB Entry DOI: 10.7270/Q21G0JH3
University of Texas Southwestern Medical Center					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Plasmodium falciparum (isolate 3D7))	BDBM24413 (JMC521864 Compund DSM2 \| N-(anthracen-2-yl)-5-meth...) Show SMILES Cc1cc(Nc2ccc3cc4ccccc4cc3c2)n2ncnc2n1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	DrugBank PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	56	n/a	n/a	n/a	n/a	8.0	20
University of Texas Southwestern Medical Center at Dallas					Assay Description The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...				J Med Chem 51: 3649-53 (2008) Article DOI: 10.1021/jm8001026 BindingDB Entry DOI: 10.7270/Q2PV6HNF
University of Texas Southwestern Medical Center at Dallas					More data for this Ligand-Target Pair				3D Structure (crystal)
Dihydroorotate dehydrogenase (quinone), mitochondrial (Plasmodium falciparum)	BDBM15349 (Asinex compound no. 4 \| N-(3-bromophenyl)-2-methyl...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	60	n/a	n/a	n/a	n/a	8.0	22
University of Texas Southwestern Medical Center					Assay Description The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...				J Biol Chem 280: 21847-53 (2005) Article DOI: 10.1074/jbc.M501100200 BindingDB Entry DOI: 10.7270/Q21G0JH3
University of Texas Southwestern Medical Center					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial [R265A] (Plasmodium falciparum)	BDBM15345 (Asinex compound no. 1 \| N-(2,4-dichlorophenyl)naph...) Show SMILES Clc1ccc(NC(=O)c2ccc3ccccc3c2)c(Cl)c1 Show InChI	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	80	n/a	n/a	n/a	n/a	n/a	n/a
University of Texas Southwestern Medical Center					Assay Description The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...				J Biol Chem 280: 21847-53 (2005) Article DOI: 10.1074/jbc.M501100200 BindingDB Entry DOI: 10.7270/Q21G0JH3
University of Texas Southwestern Medical Center					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Plasmodium falciparum)	BDBM15355 (2-methyl-3-nitro-N-[3-(trifluoromethyl)phenyl]benz...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	80	n/a	n/a	n/a	n/a	8.0	22
University of Texas Southwestern Medical Center					Assay Description The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...				J Biol Chem 280: 21847-53 (2005) Article DOI: 10.1074/jbc.M501100200 BindingDB Entry DOI: 10.7270/Q21G0JH3
University of Texas Southwestern Medical Center					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Plasmodium falciparum)	BDBM15353 (2-methyl-N-(naphthalen-1-yl)-3-nitrobenzamide \| Ch...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	80	n/a	n/a	n/a	n/a	8.0	22
University of Texas Southwestern Medical Center					Assay Description The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...				J Biol Chem 280: 21847-53 (2005) Article DOI: 10.1074/jbc.M501100200 BindingDB Entry DOI: 10.7270/Q21G0JH3
University of Texas Southwestern Medical Center					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Plasmodium falciparum)	BDBM15354 (Asinex compound no. 9 \| N-(3,4-dichlorophenyl)-2-m...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	80	n/a	n/a	n/a	n/a	8.0	22
University of Texas Southwestern Medical Center					Assay Description The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...				J Biol Chem 280: 21847-53 (2005) Article DOI: 10.1074/jbc.M501100200 BindingDB Entry DOI: 10.7270/Q21G0JH3
University of Texas Southwestern Medical Center					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Plasmodium falciparum)	BDBM15350 (ChemBridge compound no. 5 \| N-(3-chloro-4-fluoroph...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	100	n/a	n/a	n/a	n/a	8.0	22
University of Texas Southwestern Medical Center					Assay Description The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...				J Biol Chem 280: 21847-53 (2005) Article DOI: 10.1074/jbc.M501100200 BindingDB Entry DOI: 10.7270/Q21G0JH3
University of Texas Southwestern Medical Center					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Plasmodium falciparum (isolate 3D7))	BDBM24403 (5,6-dimethyl-N-(naphthalen-2-yl)-[1,2,4]triazolo[1...) Show SMILES Cc1nc2ncnn2c(Nc2ccc3ccccc3c2)c1C Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	160	n/a	n/a	n/a	n/a	8.0	20
University of Texas Southwestern Medical Center at Dallas					Assay Description The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...				J Med Chem 51: 3649-53 (2008) Article DOI: 10.1021/jm8001026 BindingDB Entry DOI: 10.7270/Q2PV6HNF
University of Texas Southwestern Medical Center at Dallas					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Plasmodium falciparum (isolate 3D7))	BDBM24402 (5-ethyl-N-(naphthalen-2-yl)-[1,2,4]triazolo[1,5-a]...) Show SMILES CCc1cc(Nc2ccc3ccccc3c2)n2ncnc2n1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	190	n/a	n/a	n/a	n/a	8.0	20
University of Texas Southwestern Medical Center at Dallas					Assay Description The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...				J Med Chem 51: 3649-53 (2008) Article DOI: 10.1021/jm8001026 BindingDB Entry DOI: 10.7270/Q2PV6HNF
University of Texas Southwestern Medical Center at Dallas					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Plasmodium falciparum (isolate 3D7))	BDBM24401 (N-(naphthalen-2-yl)-5-(trifluoromethyl)-[1,2,4]tri...) Show SMILES FC(F)(F)c1cc(Nc2ccc3ccccc3c2)n2ncnc2n1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	210	n/a	n/a	n/a	n/a	8.0	20
University of Texas Southwestern Medical Center at Dallas					Assay Description The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...				J Med Chem 51: 3649-53 (2008) Article DOI: 10.1021/jm8001026 BindingDB Entry DOI: 10.7270/Q2PV6HNF
University of Texas Southwestern Medical Center at Dallas					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Plasmodium falciparum)	BDBM15357 (3-(2-methoxyphenyl)-1-naphthalen-1-ylurea \| ChemBr...) Show SMILES COc1ccccc1NC(=O)Nc1cccc2ccccc12 Show InChI	PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	230	n/a	n/a	n/a	n/a	8.0	22
University of Texas Southwestern Medical Center					Assay Description The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...				J Biol Chem 280: 21847-53 (2005) Article DOI: 10.1074/jbc.M501100200 BindingDB Entry DOI: 10.7270/Q21G0JH3
University of Texas Southwestern Medical Center					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial [R265A] (Plasmodium falciparum)	BDBM15357 (3-(2-methoxyphenyl)-1-naphthalen-1-ylurea \| ChemBr...) Show SMILES COc1ccccc1NC(=O)Nc1cccc2ccccc12 Show InChI	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	240	n/a	n/a	n/a	n/a	n/a	n/a
University of Texas Southwestern Medical Center					Assay Description The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...				J Biol Chem 280: 21847-53 (2005) Article DOI: 10.1074/jbc.M501100200 BindingDB Entry DOI: 10.7270/Q21G0JH3
University of Texas Southwestern Medical Center					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Plasmodium falciparum)	BDBM15352 (ChemBridge compound no. 7 \| N-(3,4-difluorophenyl)...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	260	n/a	n/a	n/a	n/a	8.0	22
University of Texas Southwestern Medical Center					Assay Description The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...				J Biol Chem 280: 21847-53 (2005) Article DOI: 10.1074/jbc.M501100200 BindingDB Entry DOI: 10.7270/Q21G0JH3
University of Texas Southwestern Medical Center					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial [R265A] (Plasmodium falciparum)	BDBM15348 (ChemBridge compound no. 3 \| N-(2-fluorophenyl)naph...) Show SMILES Fc1ccccc1NC(=O)c1ccc2ccccc2c1 Show InChI	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	300	n/a	n/a	n/a	n/a	n/a	n/a
University of Texas Southwestern Medical Center					Assay Description The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...				J Biol Chem 280: 21847-53 (2005) Article DOI: 10.1074/jbc.M501100200 BindingDB Entry DOI: 10.7270/Q21G0JH3
University of Texas Southwestern Medical Center					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Plasmodium falciparum (isolate 3D7))	BDBM24409 (3-({5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl}...) Show SMILES Cc1cc(Nc2cc3ccccc3cc2O)n2ncnc2n1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	330	n/a	n/a	n/a	n/a	8.0	20
University of Texas Southwestern Medical Center at Dallas					Assay Description The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...				J Med Chem 51: 3649-53 (2008) Article DOI: 10.1021/jm8001026 BindingDB Entry DOI: 10.7270/Q2PV6HNF
University of Texas Southwestern Medical Center at Dallas					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial [R265A] (Plasmodium falciparum)	BDBM15356 (1-naphthalen-1-yl-3-[2-(trifluoromethyl)phenyl]ure...) Show SMILES FC(F)(F)c1ccccc1NC(=O)Nc1cccc2ccccc12 Show InChI	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	340	n/a	n/a	n/a	n/a	n/a	n/a
University of Texas Southwestern Medical Center					Assay Description The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...				J Biol Chem 280: 21847-53 (2005) Article DOI: 10.1074/jbc.M501100200 BindingDB Entry DOI: 10.7270/Q21G0JH3
University of Texas Southwestern Medical Center					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial [R265A] (Plasmodium falciparum)	BDBM15355 (2-methyl-3-nitro-N-[3-(trifluoromethyl)phenyl]benz...) Show SMILES Show InChI	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	370	n/a	n/a	n/a	n/a	n/a	n/a
University of Texas Southwestern Medical Center					Assay Description The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...				J Biol Chem 280: 21847-53 (2005) Article DOI: 10.1074/jbc.M501100200 BindingDB Entry DOI: 10.7270/Q21G0JH3
University of Texas Southwestern Medical Center					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial [R265A] (Plasmodium falciparum)	BDBM14711 (Asinex compound no. 6 \| N-(3,5-Dichlorophenyl)-2-m...) Show SMILES Show InChI	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	400	n/a	n/a	n/a	n/a	n/a	n/a
University of Texas Southwestern Medical Center					Assay Description The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...				J Biol Chem 280: 21847-53 (2005) Article DOI: 10.1074/jbc.M501100200 BindingDB Entry DOI: 10.7270/Q21G0JH3
University of Texas Southwestern Medical Center					More data for this Ligand-Target Pair				3D Structure (crystal)
Dihydroorotate dehydrogenase (quinone), mitochondrial (Plasmodium falciparum)	BDBM15356 (1-naphthalen-1-yl-3-[2-(trifluoromethyl)phenyl]ure...) Show SMILES FC(F)(F)c1ccccc1NC(=O)Nc1cccc2ccccc12 Show InChI	PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	400	n/a	n/a	n/a	n/a	8.0	22
University of Texas Southwestern Medical Center					Assay Description The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...				J Biol Chem 280: 21847-53 (2005) Article DOI: 10.1074/jbc.M501100200 BindingDB Entry DOI: 10.7270/Q21G0JH3
University of Texas Southwestern Medical Center					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Plasmodium falciparum)	BDBM15348 (ChemBridge compound no. 3 \| N-(2-fluorophenyl)naph...) Show SMILES Fc1ccccc1NC(=O)c1ccc2ccccc2c1 Show InChI	PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	470	n/a	n/a	n/a	n/a	8.0	22
University of Texas Southwestern Medical Center					Assay Description The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...				J Biol Chem 280: 21847-53 (2005) Article DOI: 10.1074/jbc.M501100200 BindingDB Entry DOI: 10.7270/Q21G0JH3
University of Texas Southwestern Medical Center					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial [R265A] (Plasmodium falciparum)	BDBM15353 (2-methyl-N-(naphthalen-1-yl)-3-nitrobenzamide \| Ch...) Show SMILES Show InChI	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	480	n/a	n/a	n/a	n/a	n/a	n/a
University of Texas Southwestern Medical Center					Assay Description The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...				J Biol Chem 280: 21847-53 (2005) Article DOI: 10.1074/jbc.M501100200 BindingDB Entry DOI: 10.7270/Q21G0JH3
University of Texas Southwestern Medical Center					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial [R265A] (Plasmodium falciparum)	BDBM15350 (ChemBridge compound no. 5 \| N-(3-chloro-4-fluoroph...) Show SMILES Show InChI	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	500	n/a	n/a	n/a	n/a	n/a	n/a
University of Texas Southwestern Medical Center					Assay Description The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...				J Biol Chem 280: 21847-53 (2005) Article DOI: 10.1074/jbc.M501100200 BindingDB Entry DOI: 10.7270/Q21G0JH3
University of Texas Southwestern Medical Center					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Plasmodium falciparum)	BDBM15358 (3-(4-chlorophenyl)-1-quinolin-8-ylurea \| Asinex co...) Show SMILES Clc1ccc(NC(=O)Nc2cccc3cccnc23)cc1 Show InChI	PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	780	n/a	n/a	n/a	n/a	8.0	22
University of Texas Southwestern Medical Center					Assay Description The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...				J Biol Chem 280: 21847-53 (2005) Article DOI: 10.1074/jbc.M501100200 BindingDB Entry DOI: 10.7270/Q21G0JH3
University of Texas Southwestern Medical Center					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial [R265A] (Plasmodium falciparum)	BDBM15352 (ChemBridge compound no. 7 \| N-(3,4-difluorophenyl)...) Show SMILES Show InChI	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	820	n/a	n/a	n/a	n/a	n/a	n/a
University of Texas Southwestern Medical Center					Assay Description The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...				J Biol Chem 280: 21847-53 (2005) Article DOI: 10.1074/jbc.M501100200 BindingDB Entry DOI: 10.7270/Q21G0JH3
University of Texas Southwestern Medical Center					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human))	BDBM50018011 (Aubagio \| CHEBI:68540 \| HMR-1726 \| TERIFLUNOMIDE) Show SMILES C\C(O)=C(/C#N)C(=O)Nc1ccc(cc1)C(F)(F)F Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Institut Pasteur Curated by ChEMBL					Assay Description Inhibition of human recombinant DHODH				J Med Chem 58: 5579-98 (2015) Article DOI: 10.1021/acs.jmedchem.5b00606 BindingDB Entry DOI: 10.7270/Q20V8FJT
Institut Pasteur Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Dihydroorotate dehydrogenase (quinone), mitochondrial [R265A] (Plasmodium falciparum)	BDBM15349 (Asinex compound no. 4 \| N-(3-bromophenyl)-2-methyl...) Show SMILES Show InChI	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Texas Southwestern Medical Center					Assay Description The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...				J Biol Chem 280: 21847-53 (2005) Article DOI: 10.1074/jbc.M501100200 BindingDB Entry DOI: 10.7270/Q21G0JH3
University of Texas Southwestern Medical Center					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Plasmodium falciparum (isolate 3D7))	BDBM24408 (N-{5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl}q...) Show SMILES Cc1cc(Nc2ccc3ncccc3c2)n2ncnc2n1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a	8.0	20
University of Texas Southwestern Medical Center at Dallas					Assay Description The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...				J Med Chem 51: 3649-53 (2008) Article DOI: 10.1021/jm8001026 BindingDB Entry DOI: 10.7270/Q2PV6HNF
University of Texas Southwestern Medical Center at Dallas					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Plasmodium falciparum (isolate 3D7))	BDBM24407 (N-{5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl}q...) Show SMILES Cc1cc(Nc2cnc3ccccc3c2)n2ncnc2n1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.70E+3	n/a	n/a	n/a	n/a	8.0	20
University of Texas Southwestern Medical Center at Dallas					Assay Description The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...				J Med Chem 51: 3649-53 (2008) Article DOI: 10.1021/jm8001026 BindingDB Entry DOI: 10.7270/Q2PV6HNF
University of Texas Southwestern Medical Center at Dallas					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Plasmodium falciparum (isolate 3D7))	BDBM24410 (2-methyl-7-({5-methyl-[1,2,4]triazolo[1,5-a]pyrimi...) Show SMILES Cc1cc(Nc2ccc3c(c2)oc(C)cc3=O)n2ncnc2n1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a	8.0	20
University of Texas Southwestern Medical Center at Dallas					Assay Description The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...				J Med Chem 51: 3649-53 (2008) Article DOI: 10.1021/jm8001026 BindingDB Entry DOI: 10.7270/Q2PV6HNF
University of Texas Southwestern Medical Center at Dallas					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial [R265A] (Plasmodium falciparum)	BDBM15358 (3-(4-chlorophenyl)-1-quinolin-8-ylurea \| Asinex co...) Show SMILES Clc1ccc(NC(=O)Nc2cccc3cccnc23)cc1 Show InChI	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Texas Southwestern Medical Center					Assay Description The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...				J Biol Chem 280: 21847-53 (2005) Article DOI: 10.1074/jbc.M501100200 BindingDB Entry DOI: 10.7270/Q21G0JH3
University of Texas Southwestern Medical Center					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial [R265A] (Plasmodium falciparum)	BDBM15354 (Asinex compound no. 9 \| N-(3,4-dichlorophenyl)-2-m...) Show SMILES Show InChI	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Texas Southwestern Medical Center					Assay Description The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...				J Biol Chem 280: 21847-53 (2005) Article DOI: 10.1074/jbc.M501100200 BindingDB Entry DOI: 10.7270/Q21G0JH3
University of Texas Southwestern Medical Center					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Plasmodium falciparum (isolate 3D7))	BDBM24404 (N,5-dimethyl-N-(naphthalen-2-yl)-[1,2,4]triazolo[1...) Show SMILES CN(c1ccc2ccccc2c1)c1cc(C)nc2ncnn12 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.00E+3	n/a	n/a	n/a	n/a	8.0	20
University of Texas Southwestern Medical Center at Dallas					Assay Description The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...				J Med Chem 51: 3649-53 (2008) Article DOI: 10.1021/jm8001026 BindingDB Entry DOI: 10.7270/Q2PV6HNF
University of Texas Southwestern Medical Center at Dallas					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial [30-395] (Homo sapiens (Human))	BDBM15348 (ChemBridge compound no. 3 \| N-(2-fluorophenyl)naph...) Show SMILES Fc1ccccc1NC(=O)c1ccc2ccccc2c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.40E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Texas Southwestern Medical Center					Assay Description The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...				J Biol Chem 280: 21847-53 (2005) Article DOI: 10.1074/jbc.M501100200 BindingDB Entry DOI: 10.7270/Q21G0JH3
University of Texas Southwestern Medical Center					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Plasmodium falciparum (isolate 3D7))	BDBM24411 (5-methyl-N-(naphthalen-1-yl)-[1,2,4]triazolo[1,5-a...) Show SMILES Cc1cc(Nc2cccc3ccccc23)n2ncnc2n1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.50E+4	n/a	n/a	n/a	n/a	8.0	20
University of Texas Southwestern Medical Center at Dallas					Assay Description The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...				J Med Chem 51: 3649-53 (2008) Article DOI: 10.1021/jm8001026 BindingDB Entry DOI: 10.7270/Q2PV6HNF
University of Texas Southwestern Medical Center at Dallas					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial [30-395] (Homo sapiens (Human))	BDBM15345 (Asinex compound no. 1 \| N-(2,4-dichlorophenyl)naph...) Show SMILES Clc1ccc(NC(=O)c2ccc3ccccc3c2)c(Cl)c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Texas Southwestern Medical Center					Assay Description The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...				J Biol Chem 280: 21847-53 (2005) Article DOI: 10.1074/jbc.M501100200 BindingDB Entry DOI: 10.7270/Q21G0JH3
University of Texas Southwestern Medical Center					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial [H185A] (Plasmodium falciparum)	BDBM15345 (Asinex compound no. 1 \| N-(2,4-dichlorophenyl)naph...) Show SMILES Clc1ccc(NC(=O)c2ccc3ccccc3c2)c(Cl)c1 Show InChI	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Texas Southwestern Medical Center					Assay Description The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...				J Biol Chem 280: 21847-53 (2005) Article DOI: 10.1074/jbc.M501100200 BindingDB Entry DOI: 10.7270/Q21G0JH3
University of Texas Southwestern Medical Center					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial [H185A] (Plasmodium falciparum)	BDBM15354 (Asinex compound no. 9 \| N-(3,4-dichlorophenyl)-2-m...) Show SMILES Show InChI	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Texas Southwestern Medical Center					Assay Description The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...				J Biol Chem 280: 21847-53 (2005) Article DOI: 10.1074/jbc.M501100200 BindingDB Entry DOI: 10.7270/Q21G0JH3
University of Texas Southwestern Medical Center					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial [30-395] (Homo sapiens (Human))	BDBM15354 (Asinex compound no. 9 \| N-(3,4-dichlorophenyl)-2-m...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.20E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Texas Southwestern Medical Center					Assay Description The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...				J Biol Chem 280: 21847-53 (2005) Article DOI: 10.1074/jbc.M501100200 BindingDB Entry DOI: 10.7270/Q21G0JH3
University of Texas Southwestern Medical Center					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Plasmodium falciparum (isolate 3D7))	BDBM24405 (N-benzyl-5-methyl-N-(naphthalen-2-yl)-[1,2,4]triaz...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	9.30E+4	n/a	n/a	n/a	n/a	8.0	20
University of Texas Southwestern Medical Center at Dallas					Assay Description The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...				J Med Chem 51: 3649-53 (2008) Article DOI: 10.1021/jm8001026 BindingDB Entry DOI: 10.7270/Q2PV6HNF
University of Texas Southwestern Medical Center at Dallas					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial [30-395] (Homo sapiens (Human))	BDBM15353 (2-methyl-N-(naphthalen-1-yl)-3-nitrobenzamide \| Ch...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Texas Southwestern Medical Center					Assay Description The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...				J Biol Chem 280: 21847-53 (2005) Article DOI: 10.1074/jbc.M501100200 BindingDB Entry DOI: 10.7270/Q21G0JH3
University of Texas Southwestern Medical Center					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Plasmodium falciparum (isolate 3D7))	BDBM24412 (5-methyl-N-phenyl-[1,2,4]triazolo[1,5-a]pyrimidin-...) Show SMILES Cc1cc(Nc2ccccc2)n2ncnc2n1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	8.0	20
University of Texas Southwestern Medical Center at Dallas					Assay Description The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...				J Med Chem 51: 3649-53 (2008) Article DOI: 10.1021/jm8001026 BindingDB Entry DOI: 10.7270/Q2PV6HNF
University of Texas Southwestern Medical Center at Dallas					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial [30-395] (Homo sapiens (Human))	BDBM15349 (Asinex compound no. 4 \| N-(3-bromophenyl)-2-methyl...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.05E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Texas Southwestern Medical Center					Assay Description The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...				J Biol Chem 280: 21847-53 (2005) Article DOI: 10.1074/jbc.M501100200 BindingDB Entry DOI: 10.7270/Q21G0JH3
University of Texas Southwestern Medical Center					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial [30-395] (Homo sapiens (Human))	BDBM15357 (3-(2-methoxyphenyl)-1-naphthalen-1-ylurea \| ChemBr...) Show SMILES COc1ccccc1NC(=O)Nc1cccc2ccccc12 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.12E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Texas Southwestern Medical Center					Assay Description The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...				J Biol Chem 280: 21847-53 (2005) Article DOI: 10.1074/jbc.M501100200 BindingDB Entry DOI: 10.7270/Q21G0JH3
University of Texas Southwestern Medical Center					More data for this Ligand-Target Pair

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