Compile Data Set for Download or QSAR

Found 132 hits with Last Name = 'manion' and Initial = 'tb'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Microsomal triglyceride transfer protein large subunit (Homo sapiens (Human))	BDBM50391864 (CHEMBL2147287) Show SMILES CN(Cc1ccc(F)cc1)C(=O)[C@@H](NC(=O)c1ccc2nc(NC(=O)c3ccccc3-c3ccc(cc3)C(C)(C)C)ccc2c1)c1ccccc1 |r| Show InChI InChI=1S/C43H39FN4O3/c1-43(2,3)33-20-16-29(17-21-33)35-12-8-9-13-36(35)41(50)46-38-25-19-31-26-32(18-24-37(31)45-38)40(49)47-39(30-10-6-5-7-11-30)42(51)48(4)27-28-14-22-34(44)23-15-28/h5-26,39H,27H2,1-4H3,(H,47,49)(H,45,46,50)/t39-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of MTP in human HepG2 cells assessed as unbound drug level causing inhibition of apoB secretion after 40 hrs by ELISA				Bioorg Med Chem Lett 21: 4150-4 (2011) Article DOI: 10.1016/j.bmcl.2011.05.099 BindingDB Entry DOI: 10.7270/Q2B27WCR
					More data for this Ligand-Target Pair
Microsomal triglyceride transfer protein large subunit (Homo sapiens (Human))	BDBM50391858 (CHEMBL2147281) Show SMILES CN(Cc1ccc(F)cc1)C(=O)[C@@H](NC(=O)c1ccc2nc(NC(=O)c3ccccc3-c3ccc(cc3)C(F)(F)F)ccc2c1)c1ccccc1 |r| Show InChI InChI=1S/C40H30F4N4O3/c1-48(24-25-11-19-31(41)20-12-25)39(51)36(27-7-3-2-4-8-27)47-37(49)29-15-21-34-28(23-29)16-22-35(45-34)46-38(50)33-10-6-5-9-32(33)26-13-17-30(18-14-26)40(42,43)44/h2-23,36H,24H2,1H3,(H,47,49)(H,45,46,50)/t36-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.00100	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of MTP in human HepG2 cells assessed as unbound drug level causing inhibition of apoB secretion after 40 hrs by ELISA				Bioorg Med Chem Lett 21: 4150-4 (2011) Article DOI: 10.1016/j.bmcl.2011.05.099 BindingDB Entry DOI: 10.7270/Q2B27WCR
					More data for this Ligand-Target Pair
Microsomal triglyceride transfer protein large subunit (Homo sapiens (Human))	BDBM50391863 (CHEMBL2147286) Show SMILES CC(C)c1ccc(cc1)-c1ccccc1C(=O)Nc1ccc2cc(ccc2n1)C(=O)N[C@H](C(=O)N(C)Cc1ccc(F)cc1)c1ccccc1 |r| Show InChI InChI=1S/C42H37FN4O3/c1-27(2)29-15-17-30(18-16-29)35-11-7-8-12-36(35)41(49)45-38-24-20-32-25-33(19-23-37(32)44-38)40(48)46-39(31-9-5-4-6-10-31)42(50)47(3)26-28-13-21-34(43)22-14-28/h4-25,27,39H,26H2,1-3H3,(H,46,48)(H,44,45,49)/t39-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.00100	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of MTP in human HepG2 cells assessed as unbound drug level causing inhibition of apoB secretion after 40 hrs by ELISA				Bioorg Med Chem Lett 21: 4150-4 (2011) Article DOI: 10.1016/j.bmcl.2011.05.099 BindingDB Entry DOI: 10.7270/Q2B27WCR
					More data for this Ligand-Target Pair
Microsomal triglyceride transfer protein large subunit (Homo sapiens (Human))	BDBM50391867 (CHEMBL2147290) Show SMILES CC(C)Oc1ccc(cc1)-c1ccccc1C(=O)Nc1ccc2cc(ccc2n1)C(=O)N[C@H](C(=O)N(C)Cc1ccc(F)cc1)c1ccccc1 |r| Show InChI InChI=1S/C42H37FN4O4/c1-27(2)51-34-21-15-29(16-22-34)35-11-7-8-12-36(35)41(49)45-38-24-18-31-25-32(17-23-37(31)44-38)40(48)46-39(30-9-5-4-6-10-30)42(50)47(3)26-28-13-19-33(43)20-14-28/h4-25,27,39H,26H2,1-3H3,(H,46,48)(H,44,45,49)/t39-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.00200	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of MTP in human HepG2 cells assessed as unbound drug level causing inhibition of apoB secretion after 40 hrs by ELISA				Bioorg Med Chem Lett 21: 4150-4 (2011) Article DOI: 10.1016/j.bmcl.2011.05.099 BindingDB Entry DOI: 10.7270/Q2B27WCR
					More data for this Ligand-Target Pair
Microsomal triglyceride transfer protein large subunit (Homo sapiens (Human))	BDBM50391860 (CHEMBL2147283) Show SMILES CN(Cc1ccc(F)cc1)C(=O)[C@@H](NC(=O)c1ccc2nc(NC(=O)c3ccccc3-c3ccc(C)cc3)ccc2c1)c1ccccc1 |r| Show InChI InChI=1S/C40H33FN4O3/c1-26-12-16-28(17-13-26)33-10-6-7-11-34(33)39(47)43-36-23-19-30-24-31(18-22-35(30)42-36)38(46)44-37(29-8-4-3-5-9-29)40(48)45(2)25-27-14-20-32(41)21-15-27/h3-24,37H,25H2,1-2H3,(H,44,46)(H,42,43,47)/t37-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.0100	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of MTP in human HepG2 cells assessed as unbound drug level causing inhibition of apoB secretion after 40 hrs by ELISA				Bioorg Med Chem Lett 21: 4150-4 (2011) Article DOI: 10.1016/j.bmcl.2011.05.099 BindingDB Entry DOI: 10.7270/Q2B27WCR
					More data for this Ligand-Target Pair
Microsomal triglyceride transfer protein large subunit (Homo sapiens (Human))	BDBM50204367 (CHEMBL410414 | dirlotapide) Show SMILES CN(Cc1ccccc1)C(=O)[C@@H](NC(=O)c1cc2cc(NC(=O)c3ccccc3-c3ccc(cc3)C(F)(F)F)ccc2n1C)c1ccccc1 |r| Show InChI InChI=1S/C40H33F3N4O3/c1-46(25-26-11-5-3-6-12-26)39(50)36(28-13-7-4-8-14-28)45-38(49)35-24-29-23-31(21-22-34(29)47(35)2)44-37(48)33-16-10-9-15-32(33)27-17-19-30(20-18-27)40(41,42)43/h3-24,36H,25H2,1-2H3,(H,44,48)(H,45,49)/t36-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	0.0110	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of MTP in human HepG2 cells assessed as unbound drug level causing inhibition of apoB secretion after 40 hrs by ELISA				Bioorg Med Chem Lett 21: 4150-4 (2011) Article DOI: 10.1016/j.bmcl.2011.05.099 BindingDB Entry DOI: 10.7270/Q2B27WCR
					More data for this Ligand-Target Pair
Microsomal triglyceride transfer protein large subunit (Homo sapiens (Human))	BDBM50391875 (CHEMBL2147296) Show SMILES CNC(=O)[C@@H](NC(=O)c1ccc2nc(NC(=O)c3ccccc3-c3ccc(cc3)C(C)(C)C)ccc2c1)c1ccccc1 |r| Show InChI InChI=1S/C36H34N4O3/c1-36(2,3)27-18-14-23(15-19-27)28-12-8-9-13-29(28)34(42)39-31-21-17-25-22-26(16-20-30(25)38-31)33(41)40-32(35(43)37-4)24-10-6-5-7-11-24/h5-22,32H,1-4H3,(H,37,43)(H,40,41)(H,38,39,42)/t32-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.0210	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of MTP in human HepG2 cells assessed as unbound drug level causing inhibition of apoB secretion after 40 hrs by ELISA				Bioorg Med Chem Lett 21: 4150-4 (2011) Article DOI: 10.1016/j.bmcl.2011.05.099 BindingDB Entry DOI: 10.7270/Q2B27WCR
					More data for this Ligand-Target Pair
Microsomal triglyceride transfer protein large subunit (Homo sapiens (Human))	BDBM50391876 (CHEMBL2147292) Show SMILES CN(Cc1ccc(F)cc1)C(=O)[C@@H](NC(=O)c1ccc2nc(NC(=O)c3ccccc3-c3ccc(cc3)C(C)(C)CO)ccc2c1)c1ccccc1 |r| Show InChI InChI=1S/C43H39FN4O4/c1-43(2,27-49)33-19-15-29(16-20-33)35-11-7-8-12-36(35)41(51)46-38-24-18-31-25-32(17-23-37(31)45-38)40(50)47-39(30-9-5-4-6-10-30)42(52)48(3)26-28-13-21-34(44)22-14-28/h4-25,39,49H,26-27H2,1-3H3,(H,47,50)(H,45,46,51)/t39-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.0250	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of MTP in human HepG2 cells assessed as unbound drug level causing inhibition of apoB secretion after 40 hrs by ELISA				Bioorg Med Chem Lett 21: 4150-4 (2011) Article DOI: 10.1016/j.bmcl.2011.05.099 BindingDB Entry DOI: 10.7270/Q2B27WCR
					More data for this Ligand-Target Pair
Microsomal triglyceride transfer protein large subunit (Homo sapiens (Human))	BDBM50391866 (CHEMBL2147294) Show SMILES CC(C)(CO)c1ccc(cc1)-c1ccccc1C(=O)Nc1ccc2cc(ccc2n1)C(=O)N[C@H](C(=O)NCc1ccc(F)cc1)c1ccccc1 |r| Show InChI InChI=1S/C42H37FN4O4/c1-42(2,26-48)32-18-14-28(15-19-32)34-10-6-7-11-35(34)40(50)46-37-23-17-30-24-31(16-22-36(30)45-37)39(49)47-38(29-8-4-3-5-9-29)41(51)44-25-27-12-20-33(43)21-13-27/h3-24,38,48H,25-26H2,1-2H3,(H,44,51)(H,47,49)(H,45,46,50)/t38-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.0580	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of MTP in human HepG2 cells assessed as unbound drug level causing inhibition of apoB secretion after 40 hrs by ELISA				Bioorg Med Chem Lett 21: 4150-4 (2011) Article DOI: 10.1016/j.bmcl.2011.05.099 BindingDB Entry DOI: 10.7270/Q2B27WCR
					More data for this Ligand-Target Pair
Microsomal triglyceride transfer protein large subunit (Homo sapiens (Human))	BDBM50391877 (CHEMBL2147293) Show SMILES CN(Cc1ccc(F)cc1)C(=O)[C@@H](NC(=O)c1ccc2nc(NC(=O)c3ccccc3-c3ccc(cc3)C(C)(C)C(O)=O)ccc2c1)c1ccccc1 |r| Show InChI InChI=1S/C43H37FN4O5/c1-43(2,42(52)53)32-19-15-28(16-20-32)34-11-7-8-12-35(34)40(50)46-37-24-18-30-25-31(17-23-36(30)45-37)39(49)47-38(29-9-5-4-6-10-29)41(51)48(3)26-27-13-21-33(44)22-14-27/h4-25,38H,26H2,1-3H3,(H,47,49)(H,52,53)(H,45,46,50)/t38-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.0660	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of MTP in human HepG2 cells assessed as unbound drug level causing inhibition of apoB secretion after 40 hrs by ELISA				Bioorg Med Chem Lett 21: 4150-4 (2011) Article DOI: 10.1016/j.bmcl.2011.05.099 BindingDB Entry DOI: 10.7270/Q2B27WCR
					More data for this Ligand-Target Pair
Microsomal triglyceride transfer protein large subunit (Homo sapiens (Human))	BDBM50391869 (CHEMBL2147301) Show SMILES CNC(=O)[C@@H](NC(=O)c1ccc2nc(NC(=O)c3ccccc3-c3ccc(OC(C)C)cc3)ccc2c1)c1ccccc1 |r| Show InChI InChI=1S/C35H32N4O4/c1-22(2)43-27-17-13-23(14-18-27)28-11-7-8-12-29(28)34(41)38-31-20-16-25-21-26(15-19-30(25)37-31)33(40)39-32(35(42)36-3)24-9-5-4-6-10-24/h4-22,32H,1-3H3,(H,36,42)(H,39,40)(H,37,38,41)/t32-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.101	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of MTP in human HepG2 cells assessed as unbound drug level causing inhibition of apoB secretion after 40 hrs by ELISA				Bioorg Med Chem Lett 21: 4150-4 (2011) Article DOI: 10.1016/j.bmcl.2011.05.099 BindingDB Entry DOI: 10.7270/Q2B27WCR
					More data for this Ligand-Target Pair
Microsomal triglyceride transfer protein large subunit (Homo sapiens (Human))	BDBM50391871 (CHEMBL2147298) Show SMILES CN(Cc1ccc(F)cc1)C(=O)[C@@H](NC(=O)c1ccc2nc(NC(=O)c3ccccc3-c3ccc(O)cc3)ccc2c1)c1ccccc1 |r| Show InChI InChI=1S/C39H31FN4O4/c1-44(24-25-11-17-30(40)18-12-25)39(48)36(27-7-3-2-4-8-27)43-37(46)29-15-21-34-28(23-29)16-22-35(41-34)42-38(47)33-10-6-5-9-32(33)26-13-19-31(45)20-14-26/h2-23,36,45H,24H2,1H3,(H,43,46)(H,41,42,47)/t36-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.105	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of MTP in human HepG2 cells assessed as unbound drug level causing inhibition of apoB secretion after 40 hrs by ELISA				Bioorg Med Chem Lett 21: 4150-4 (2011) Article DOI: 10.1016/j.bmcl.2011.05.099 BindingDB Entry DOI: 10.7270/Q2B27WCR
					More data for this Ligand-Target Pair
Microsomal triglyceride transfer protein large subunit (Homo sapiens (Human))	BDBM50391872 (CHEMBL2147299) Show SMILES CC(CO)Oc1ccc(cc1)-c1ccccc1C(=O)Nc1ccc2cc(ccc2n1)C(=O)N[C@H](C(=O)N(C)Cc1ccc(F)cc1)c1ccccc1 |r| Show InChI InChI=1S/C42H37FN4O5/c1-27(26-48)52-34-20-14-29(15-21-34)35-10-6-7-11-36(35)41(50)45-38-23-17-31-24-32(16-22-37(31)44-38)40(49)46-39(30-8-4-3-5-9-30)42(51)47(2)25-28-12-18-33(43)19-13-28/h3-24,27,39,48H,25-26H2,1-2H3,(H,46,49)(H,44,45,50)/t27?,39-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.122	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of MTP in human HepG2 cells assessed as unbound drug level causing inhibition of apoB secretion after 40 hrs by ELISA				Bioorg Med Chem Lett 21: 4150-4 (2011) Article DOI: 10.1016/j.bmcl.2011.05.099 BindingDB Entry DOI: 10.7270/Q2B27WCR
					More data for this Ligand-Target Pair
Microsomal triglyceride transfer protein large subunit (Homo sapiens (Human))	BDBM50391874 (CHEMBL2147295) Show SMILES CC(C)(C(O)=O)c1ccc(cc1)-c1ccccc1C(=O)Nc1ccc2cc(ccc2n1)C(=O)N[C@H](C(=O)NCc1ccc(F)cc1)c1ccccc1 |r| Show InChI InChI=1S/C42H35FN4O5/c1-42(2,41(51)52)31-18-14-27(15-19-31)33-10-6-7-11-34(33)39(49)46-36-23-17-29-24-30(16-22-35(29)45-36)38(48)47-37(28-8-4-3-5-9-28)40(50)44-25-26-12-20-32(43)21-13-26/h3-24,37H,25H2,1-2H3,(H,44,50)(H,47,48)(H,51,52)(H,45,46,49)/t37-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.253	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of MTP in human HepG2 cells assessed as unbound drug level causing inhibition of apoB secretion after 40 hrs by ELISA				Bioorg Med Chem Lett 21: 4150-4 (2011) Article DOI: 10.1016/j.bmcl.2011.05.099 BindingDB Entry DOI: 10.7270/Q2B27WCR
					More data for this Ligand-Target Pair
Microsomal triglyceride transfer protein large subunit (Homo sapiens (Human))	BDBM50391857 (CHEMBL2147280) Show SMILES Cn1c(cc2cc(NC(=O)c3ccccc3-c3ccc(cc3)C(F)(F)F)ccc12)C(=O)N[C@H](C(N)=O)c1ccccc1 |r| Show InChI InChI=1S/C32H25F3N4O3/c1-39-26-16-15-23(17-21(26)18-27(39)31(42)38-28(29(36)40)20-7-3-2-4-8-20)37-30(41)25-10-6-5-9-24(25)19-11-13-22(14-12-19)32(33,34)35/h2-18,28H,1H3,(H2,36,40)(H,37,41)(H,38,42)/t28-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.345	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of MTP in human HepG2 cells assessed as unbound drug level causing inhibition of apoB secretion after 40 hrs by ELISA				Bioorg Med Chem Lett 21: 4150-4 (2011) Article DOI: 10.1016/j.bmcl.2011.05.099 BindingDB Entry DOI: 10.7270/Q2B27WCR
					More data for this Ligand-Target Pair
Microsomal triglyceride transfer protein large subunit (Homo sapiens (Human))	BDBM50391856 (CHEMBL2147279) Show SMILES CNC(=O)[C@@H](NC(=O)c1cc2cc(NC(=O)c3ccccc3-c3ccc(cc3)C(F)(F)F)ccc2n1C)c1ccccc1 |r| Show InChI InChI=1S/C33H27F3N4O3/c1-37-32(43)29(21-8-4-3-5-9-21)39-31(42)28-19-22-18-24(16-17-27(22)40(28)2)38-30(41)26-11-7-6-10-25(26)20-12-14-23(15-13-20)33(34,35)36/h3-19,29H,1-2H3,(H,37,43)(H,38,41)(H,39,42)/t29-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.378	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of MTP in human HepG2 cells assessed as unbound drug level causing inhibition of apoB secretion after 40 hrs by ELISA				Bioorg Med Chem Lett 21: 4150-4 (2011) Article DOI: 10.1016/j.bmcl.2011.05.099 BindingDB Entry DOI: 10.7270/Q2B27WCR
					More data for this Ligand-Target Pair
Microsomal triglyceride transfer protein large subunit (Homo sapiens (Human))	BDBM50391862 (CHEMBL2147285) Show SMILES CCCc1ccc(cc1)-c1ccccc1C(=O)Nc1ccc2cc(ccc2n1)C(=O)N[C@H](C(=O)N(C)Cc1ccc(F)cc1)c1ccccc1 |r| Show InChI InChI=1S/C42H37FN4O3/c1-3-9-28-14-18-30(19-15-28)35-12-7-8-13-36(35)41(49)45-38-25-21-32-26-33(20-24-37(32)44-38)40(48)46-39(31-10-5-4-6-11-31)42(50)47(2)27-29-16-22-34(43)23-17-29/h4-8,10-26,39H,3,9,27H2,1-2H3,(H,46,48)(H,44,45,49)/t39-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.440	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of MTP in human HepG2 cells assessed as inhibition of apoB secretion after 40 hrs by ELISA				Bioorg Med Chem Lett 21: 4150-4 (2011) Article DOI: 10.1016/j.bmcl.2011.05.099 BindingDB Entry DOI: 10.7270/Q2B27WCR
					More data for this Ligand-Target Pair
Microsomal triglyceride transfer protein large subunit (Homo sapiens (Human))	BDBM50391870 (CHEMBL2147300) Show SMILES CC(Oc1ccc(cc1)-c1ccccc1C(=O)Nc1ccc2cc(ccc2n1)C(=O)N[C@H](C(=O)N(C)Cc1ccc(F)cc1)c1ccccc1)C(O)=O |r| Show InChI InChI=1S/C42H35FN4O6/c1-26(42(51)52)53-33-20-14-28(15-21-33)34-10-6-7-11-35(34)40(49)45-37-23-17-30-24-31(16-22-36(30)44-37)39(48)46-38(29-8-4-3-5-9-29)41(50)47(2)25-27-12-18-32(43)19-13-27/h3-24,26,38H,25H2,1-2H3,(H,46,48)(H,51,52)(H,44,45,49)/t26?,38-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.484	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of MTP in human HepG2 cells assessed as unbound drug level causing inhibition of apoB secretion after 40 hrs by ELISA				Bioorg Med Chem Lett 21: 4150-4 (2011) Article DOI: 10.1016/j.bmcl.2011.05.099 BindingDB Entry DOI: 10.7270/Q2B27WCR
					More data for this Ligand-Target Pair
Microsomal triglyceride transfer protein large subunit (Homo sapiens (Human))	BDBM50391861 (CHEMBL2147284) Show SMILES CCc1ccc(cc1)-c1ccccc1C(=O)Nc1ccc2cc(ccc2n1)C(=O)N[C@H](C(=O)N(C)Cc1ccc(F)cc1)c1ccccc1 |r| Show InChI InChI=1S/C41H35FN4O3/c1-3-27-13-17-29(18-14-27)34-11-7-8-12-35(34)40(48)44-37-24-20-31-25-32(19-23-36(31)43-37)39(47)45-38(30-9-5-4-6-10-30)41(49)46(2)26-28-15-21-33(42)22-16-28/h4-25,38H,3,26H2,1-2H3,(H,45,47)(H,43,44,48)/t38-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.550	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of MTP in human HepG2 cells assessed as inhibition of apoB secretion after 40 hrs by ELISA				Bioorg Med Chem Lett 21: 4150-4 (2011) Article DOI: 10.1016/j.bmcl.2011.05.099 BindingDB Entry DOI: 10.7270/Q2B27WCR
					More data for this Ligand-Target Pair
Microsomal triglyceride transfer protein large subunit (Homo sapiens (Human))	BDBM50391875 (CHEMBL2147296) Show SMILES CNC(=O)[C@@H](NC(=O)c1ccc2nc(NC(=O)c3ccccc3-c3ccc(cc3)C(C)(C)C)ccc2c1)c1ccccc1 |r| Show InChI InChI=1S/C36H34N4O3/c1-36(2,3)27-18-14-23(15-19-27)28-12-8-9-13-29(28)34(42)39-31-21-17-25-22-26(16-20-30(25)38-31)33(41)40-32(35(43)37-4)24-10-6-5-7-11-24/h5-22,32H,1-4H3,(H,37,43)(H,40,41)(H,38,39,42)/t32-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.560	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of MTP in human HepG2 cells assessed as inhibition of apoB secretion after 40 hrs by ELISA				Bioorg Med Chem Lett 21: 4150-4 (2011) Article DOI: 10.1016/j.bmcl.2011.05.099 BindingDB Entry DOI: 10.7270/Q2B27WCR
					More data for this Ligand-Target Pair
Microsomal triglyceride transfer protein large subunit (Homo sapiens (Human))	BDBM50391863 (CHEMBL2147286) Show SMILES CC(C)c1ccc(cc1)-c1ccccc1C(=O)Nc1ccc2cc(ccc2n1)C(=O)N[C@H](C(=O)N(C)Cc1ccc(F)cc1)c1ccccc1 |r| Show InChI InChI=1S/C42H37FN4O3/c1-27(2)29-15-17-30(18-16-29)35-11-7-8-12-36(35)41(49)45-38-24-20-32-25-33(19-23-37(32)44-38)40(48)46-39(31-9-5-4-6-10-31)42(50)47(3)26-28-13-21-34(43)22-14-28/h4-25,27,39H,26H2,1-3H3,(H,46,48)(H,44,45,49)/t39-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.600	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of MTP in human HepG2 cells assessed as inhibition of apoB secretion after 40 hrs by ELISA				Bioorg Med Chem Lett 21: 4150-4 (2011) Article DOI: 10.1016/j.bmcl.2011.05.099 BindingDB Entry DOI: 10.7270/Q2B27WCR
					More data for this Ligand-Target Pair
Microsomal triglyceride transfer protein large subunit (Homo sapiens (Human))	BDBM50391869 (CHEMBL2147301) Show SMILES CNC(=O)[C@@H](NC(=O)c1ccc2nc(NC(=O)c3ccccc3-c3ccc(OC(C)C)cc3)ccc2c1)c1ccccc1 |r| Show InChI InChI=1S/C35H32N4O4/c1-22(2)43-27-17-13-23(14-18-27)28-11-7-8-12-29(28)34(41)38-31-20-16-25-21-26(15-19-30(25)37-31)33(40)39-32(35(42)36-3)24-9-5-4-6-10-24/h4-22,32H,1-3H3,(H,36,42)(H,39,40)(H,37,38,41)/t32-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.630	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of MTP in human HepG2 cells assessed as inhibition of apoB secretion after 40 hrs by ELISA				Bioorg Med Chem Lett 21: 4150-4 (2011) Article DOI: 10.1016/j.bmcl.2011.05.099 BindingDB Entry DOI: 10.7270/Q2B27WCR
					More data for this Ligand-Target Pair
Microsomal triglyceride transfer protein large subunit (Homo sapiens (Human))	BDBM50391858 (CHEMBL2147281) Show SMILES CN(Cc1ccc(F)cc1)C(=O)[C@@H](NC(=O)c1ccc2nc(NC(=O)c3ccccc3-c3ccc(cc3)C(F)(F)F)ccc2c1)c1ccccc1 |r| Show InChI InChI=1S/C40H30F4N4O3/c1-48(24-25-11-19-31(41)20-12-25)39(51)36(27-7-3-2-4-8-27)47-37(49)29-15-21-34-28(23-29)16-22-35(45-34)46-38(50)33-10-6-5-9-32(33)26-13-17-30(18-14-26)40(42,43)44/h2-23,36H,24H2,1H3,(H,47,49)(H,45,46,50)/t36-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.740	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of MTP in human HepG2 cells assessed as inhibition of apoB secretion after 40 hrs by ELISA				Bioorg Med Chem Lett 21: 4150-4 (2011) Article DOI: 10.1016/j.bmcl.2011.05.099 BindingDB Entry DOI: 10.7270/Q2B27WCR
					More data for this Ligand-Target Pair
Microsomal triglyceride transfer protein large subunit (Homo sapiens (Human))	BDBM50391867 (CHEMBL2147290) Show SMILES CC(C)Oc1ccc(cc1)-c1ccccc1C(=O)Nc1ccc2cc(ccc2n1)C(=O)N[C@H](C(=O)N(C)Cc1ccc(F)cc1)c1ccccc1 |r| Show InChI InChI=1S/C42H37FN4O4/c1-27(2)51-34-21-15-29(16-22-34)35-11-7-8-12-36(35)41(49)45-38-24-18-31-25-32(17-23-37(31)44-38)40(48)46-39(30-9-5-4-6-10-30)42(50)47(3)26-28-13-19-33(43)20-14-28/h4-25,27,39H,26H2,1-3H3,(H,46,48)(H,44,45,49)/t39-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.770	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of MTP in human HepG2 cells assessed as inhibition of apoB secretion after 40 hrs by ELISA				Bioorg Med Chem Lett 21: 4150-4 (2011) Article DOI: 10.1016/j.bmcl.2011.05.099 BindingDB Entry DOI: 10.7270/Q2B27WCR
					More data for this Ligand-Target Pair
Microsomal triglyceride transfer protein large subunit (Homo sapiens (Human))	BDBM50391865 (CHEMBL2147291) Show SMILES CN(Cc1ccc(F)cc1)C(=O)[C@@H](NC(=O)c1ccc2nc(NC(=O)c3ccccc3-c3ccc(OC(C)(C)C)cc3)ccc2c1)c1ccccc1 |r| Show InChI InChI=1S/C43H39FN4O4/c1-43(2,3)52-34-22-16-29(17-23-34)35-12-8-9-13-36(35)41(50)46-38-25-19-31-26-32(18-24-37(31)45-38)40(49)47-39(30-10-6-5-7-11-30)42(51)48(4)27-28-14-20-33(44)21-15-28/h5-26,39H,27H2,1-4H3,(H,47,49)(H,45,46,50)/t39-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.830	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of MTP in human HepG2 cells assessed as inhibition of apoB secretion after 40 hrs by ELISA				Bioorg Med Chem Lett 21: 4150-4 (2011) Article DOI: 10.1016/j.bmcl.2011.05.099 BindingDB Entry DOI: 10.7270/Q2B27WCR
					More data for this Ligand-Target Pair
Microsomal triglyceride transfer protein large subunit (Homo sapiens (Human))	BDBM50184105 (4'-trifluoromethyl-biphenyl-2-carboxylic acid (4-{...) Show SMILES COc1cc(NC(=O)c2ccccc2-c2ccc(cc2)C(F)(F)F)ccc1C(=O)N[C@H](C(=O)NCC1CC1)c1ccccc1 Show InChI InChI=1S/C34H30F3N3O4/c1-44-29-19-25(39-31(41)27-10-6-5-9-26(27)22-13-15-24(16-14-22)34(35,36)37)17-18-28(29)32(42)40-30(23-7-3-2-4-8-23)33(43)38-20-21-11-12-21/h2-10,13-19,21,30H,11-12,20H2,1H3,(H,38,43)(H,39,41)(H,40,42)/t30-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.01	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of MTP in canine liver microsomes				Bioorg Med Chem Lett 16: 3039-42 (2006) Article DOI: 10.1016/j.bmcl.2006.02.058 BindingDB Entry DOI: 10.7270/Q2D21X68
					More data for this Ligand-Target Pair
Microsomal triglyceride transfer protein large subunit (Homo sapiens (Human))	BDBM50391876 (CHEMBL2147292) Show SMILES CN(Cc1ccc(F)cc1)C(=O)[C@@H](NC(=O)c1ccc2nc(NC(=O)c3ccccc3-c3ccc(cc3)C(C)(C)CO)ccc2c1)c1ccccc1 |r| Show InChI InChI=1S/C43H39FN4O4/c1-43(2,27-49)33-19-15-29(16-20-33)35-11-7-8-12-36(35)41(51)46-38-24-18-31-25-32(17-23-37(31)45-38)40(50)47-39(30-9-5-4-6-10-30)42(52)48(3)26-28-13-21-34(44)22-14-28/h4-25,39,49H,26-27H2,1-3H3,(H,47,50)(H,45,46,51)/t39-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of MTP in human HepG2 cells assessed as inhibition of apoB secretion after 40 hrs by ELISA				Bioorg Med Chem Lett 21: 4150-4 (2011) Article DOI: 10.1016/j.bmcl.2011.05.099 BindingDB Entry DOI: 10.7270/Q2B27WCR
					More data for this Ligand-Target Pair
Microsomal triglyceride transfer protein large subunit (Homo sapiens (Human))	BDBM50391868 (CHEMBL2146489) Show SMILES CC(C)Oc1ccc(cc1)-c1ccccc1C(=O)Nc1ccc2cc(ccc2n1)C(=O)N[C@H](C(=O)NCc1ccc(F)cc1)c1ccccc1 |r| Show InChI InChI=1S/C41H35FN4O4/c1-26(2)50-33-20-14-28(15-21-33)34-10-6-7-11-35(34)40(48)45-37-23-17-30-24-31(16-22-36(30)44-37)39(47)46-38(29-8-4-3-5-9-29)41(49)43-25-27-12-18-32(42)19-13-27/h3-24,26,38H,25H2,1-2H3,(H,43,49)(H,46,47)(H,44,45,48)/t38-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.20	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of MTP in human HepG2 cells assessed as inhibition of apoB secretion after 40 hrs by ELISA				Bioorg Med Chem Lett 21: 4150-4 (2011) Article DOI: 10.1016/j.bmcl.2011.05.099 BindingDB Entry DOI: 10.7270/Q2B27WCR
					More data for this Ligand-Target Pair
Microsomal triglyceride transfer protein large subunit (Homo sapiens (Human))	BDBM50391873 (CHEMBL2147297) Show SMILES CC(C)(C)c1ccc(cc1)-c1ccccc1C(=O)Nc1ccc2cc(ccc2n1)C(=O)N[C@H](C(=O)NCc1ccc(F)cc1)c1ccccc1 |r| Show InChI InChI=1S/C42H37FN4O3/c1-42(2,3)32-19-15-28(16-20-32)34-11-7-8-12-35(34)40(49)46-37-24-18-30-25-31(17-23-36(30)45-37)39(48)47-38(29-9-5-4-6-10-29)41(50)44-26-27-13-21-33(43)22-14-27/h4-25,38H,26H2,1-3H3,(H,44,50)(H,47,48)(H,45,46,49)/t38-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.20	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of MTP in human HepG2 cells assessed as inhibition of apoB secretion after 40 hrs by ELISA				Bioorg Med Chem Lett 21: 4150-4 (2011) Article DOI: 10.1016/j.bmcl.2011.05.099 BindingDB Entry DOI: 10.7270/Q2B27WCR
					More data for this Ligand-Target Pair
Microsomal triglyceride transfer protein large subunit (Homo sapiens (Human))	BDBM50391873 (CHEMBL2147297) Show SMILES CC(C)(C)c1ccc(cc1)-c1ccccc1C(=O)Nc1ccc2cc(ccc2n1)C(=O)N[C@H](C(=O)NCc1ccc(F)cc1)c1ccccc1 |r| Show InChI InChI=1S/C42H37FN4O3/c1-42(2,3)32-19-15-28(16-20-32)34-11-7-8-12-35(34)40(49)46-37-24-18-30-25-31(17-23-36(30)45-37)39(48)47-38(29-9-5-4-6-10-29)41(50)44-26-27-13-21-33(43)22-14-27/h4-25,38H,26H2,1-3H3,(H,44,50)(H,47,48)(H,45,46,49)/t38-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.20	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of MTP in human HepG2 cells assessed as inhibition of apoB secretion after 40 hrs by ELISA				Bioorg Med Chem Lett 21: 4150-4 (2011) Article DOI: 10.1016/j.bmcl.2011.05.099 BindingDB Entry DOI: 10.7270/Q2B27WCR
					More data for this Ligand-Target Pair
Microsomal triglyceride transfer protein large subunit (Homo sapiens (Human))	BDBM50391864 (CHEMBL2147287) Show SMILES CN(Cc1ccc(F)cc1)C(=O)[C@@H](NC(=O)c1ccc2nc(NC(=O)c3ccccc3-c3ccc(cc3)C(C)(C)C)ccc2c1)c1ccccc1 |r| Show InChI InChI=1S/C43H39FN4O3/c1-43(2,3)33-20-16-29(17-21-33)35-12-8-9-13-36(35)41(50)46-38-25-19-31-26-32(18-24-37(31)45-38)40(49)47-39(30-10-6-5-7-11-30)42(51)48(4)27-28-14-22-34(44)23-15-28/h5-26,39H,27H2,1-4H3,(H,47,49)(H,45,46,50)/t39-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.20	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of MTP in human HepG2 cells assessed as inhibition of apoB secretion after 40 hrs by ELISA				Bioorg Med Chem Lett 21: 4150-4 (2011) Article DOI: 10.1016/j.bmcl.2011.05.099 BindingDB Entry DOI: 10.7270/Q2B27WCR
					More data for this Ligand-Target Pair
Microsomal triglyceride transfer protein large subunit (Homo sapiens (Human))	BDBM50391868 (CHEMBL2146489) Show SMILES CC(C)Oc1ccc(cc1)-c1ccccc1C(=O)Nc1ccc2cc(ccc2n1)C(=O)N[C@H](C(=O)NCc1ccc(F)cc1)c1ccccc1 |r| Show InChI InChI=1S/C41H35FN4O4/c1-26(2)50-33-20-14-28(15-21-33)34-10-6-7-11-35(34)40(48)45-37-23-17-30-24-31(16-22-36(30)44-37)39(47)46-38(29-8-4-3-5-9-29)41(49)43-25-27-12-18-32(42)19-13-27/h3-24,26,38H,25H2,1-2H3,(H,43,49)(H,46,47)(H,44,45,48)/t38-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.21	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of MTP in human HepG2 cells assessed as inhibition of apoB secretion after 40 hrs by ELISA				Bioorg Med Chem Lett 21: 4150-4 (2011) Article DOI: 10.1016/j.bmcl.2011.05.099 BindingDB Entry DOI: 10.7270/Q2B27WCR
					More data for this Ligand-Target Pair
Microsomal triglyceride transfer protein large subunit (Homo sapiens (Human))	BDBM50391857 (CHEMBL2147280) Show SMILES Cn1c(cc2cc(NC(=O)c3ccccc3-c3ccc(cc3)C(F)(F)F)ccc12)C(=O)N[C@H](C(N)=O)c1ccccc1 |r| Show InChI InChI=1S/C32H25F3N4O3/c1-39-26-16-15-23(17-21(26)18-27(39)31(42)38-28(29(36)40)20-7-3-2-4-8-20)37-30(41)25-10-6-5-9-24(25)19-11-13-22(14-12-19)32(33,34)35/h2-18,28H,1H3,(H2,36,40)(H,37,41)(H,38,42)/t28-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.5	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of MTP in human HepG2 cells assessed as inhibition of apoB secretion after 40 hrs by ELISA				Bioorg Med Chem Lett 21: 4150-4 (2011) Article DOI: 10.1016/j.bmcl.2011.05.099 BindingDB Entry DOI: 10.7270/Q2B27WCR
					More data for this Ligand-Target Pair
Microsomal triglyceride transfer protein large subunit (Homo sapiens (Human))	BDBM50184109 (4'-trifluoromethyl-biphenyl-2-carboxylic acid {2-m...) Show SMILES CCCNC(=O)[C@@H](NC(=O)c1ccc(NC(=O)c2ccccc2-c2ccc(cc2)C(F)(F)F)c(C)c1)c1ccccc1 Show InChI InChI=1S/C33H30F3N3O3/c1-3-19-37-32(42)29(23-9-5-4-6-10-23)39-30(40)24-15-18-28(21(2)20-24)38-31(41)27-12-8-7-11-26(27)22-13-16-25(17-14-22)33(34,35)36/h4-18,20,29H,3,19H2,1-2H3,(H,37,42)(H,38,41)(H,39,40)/t29-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.64	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of MTP in canine liver microsomes				Bioorg Med Chem Lett 16: 3039-42 (2006) Article DOI: 10.1016/j.bmcl.2006.02.058 BindingDB Entry DOI: 10.7270/Q2D21X68
					More data for this Ligand-Target Pair
Microsomal triglyceride transfer protein large subunit (Homo sapiens (Human))	BDBM50184153 (4'-trifluoromethyl-biphenyl-2-carboxylic acid (4-{...) Show SMILES COc1cc(ccc1NC(=O)c1ccccc1-c1ccc(cc1)C(F)(F)F)C(=O)N[C@H](C(=O)NCC1CC1)c1ccccc1 Show InChI InChI=1S/C34H30F3N3O4/c1-44-29-19-24(31(41)40-30(23-7-3-2-4-8-23)33(43)38-20-21-11-12-21)15-18-28(29)39-32(42)27-10-6-5-9-26(27)22-13-16-25(17-14-22)34(35,36)37/h2-10,13-19,21,30H,11-12,20H2,1H3,(H,38,43)(H,39,42)(H,40,41)/t30-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.68	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of MTP in canine liver microsomes				Bioorg Med Chem Lett 16: 3039-42 (2006) Article DOI: 10.1016/j.bmcl.2006.02.058 BindingDB Entry DOI: 10.7270/Q2D21X68
					More data for this Ligand-Target Pair
Microsomal triglyceride transfer protein large subunit (Homo sapiens (Human))	BDBM50184111 (4'-trifluoromethyl-biphenyl-2-carboxylic acid [2-m...) Show SMILES COc1cc(ccc1NC(=O)c1ccccc1-c1ccc(cc1)C(F)(F)F)C(=O)N[C@H](C(=O)N1CCCC1)c1ccccc1 Show InChI InChI=1S/C34H30F3N3O4/c1-44-29-21-24(31(41)39-30(23-9-3-2-4-10-23)33(43)40-19-7-8-20-40)15-18-28(29)38-32(42)27-12-6-5-11-26(27)22-13-16-25(17-14-22)34(35,36)37/h2-6,9-18,21,30H,7-8,19-20H2,1H3,(H,38,42)(H,39,41)/t30-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.75	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of MTP in canine liver microsomes				Bioorg Med Chem Lett 16: 3039-42 (2006) Article DOI: 10.1016/j.bmcl.2006.02.058 BindingDB Entry DOI: 10.7270/Q2D21X68
					More data for this Ligand-Target Pair
Microsomal triglyceride transfer protein large subunit (Homo sapiens (Human))	BDBM50184165 (4'-trifluoromethyl-biphenyl-2-carboxylic acid (4-{...) Show SMILES Cc1cc(ccc1NC(=O)c1ccccc1-c1ccc(cc1)C(F)(F)F)C(=O)N[C@H](C(=O)NCC1CC1)c1ccccc1 Show InChI InChI=1S/C34H30F3N3O3/c1-21-19-25(31(41)40-30(24-7-3-2-4-8-24)33(43)38-20-22-11-12-22)15-18-29(21)39-32(42)28-10-6-5-9-27(28)23-13-16-26(17-14-23)34(35,36)37/h2-10,13-19,22,30H,11-12,20H2,1H3,(H,38,43)(H,39,42)(H,40,41)/t30-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.78	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of MTP in canine liver microsomes				Bioorg Med Chem Lett 16: 3039-42 (2006) Article DOI: 10.1016/j.bmcl.2006.02.058 BindingDB Entry DOI: 10.7270/Q2D21X68
					More data for this Ligand-Target Pair
Microsomal triglyceride transfer protein large subunit (Homo sapiens (Human))	BDBM50391856 (CHEMBL2147279) Show SMILES CNC(=O)[C@@H](NC(=O)c1cc2cc(NC(=O)c3ccccc3-c3ccc(cc3)C(F)(F)F)ccc2n1C)c1ccccc1 |r| Show InChI InChI=1S/C33H27F3N4O3/c1-37-32(43)29(21-8-4-3-5-9-21)39-31(42)28-19-22-18-24(16-17-27(22)40(28)2)38-30(41)26-11-7-6-10-25(26)20-12-14-23(15-13-20)33(34,35)36/h3-19,29H,1-2H3,(H,37,43)(H,38,41)(H,39,42)/t29-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.80	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of MTP in human HepG2 cells assessed as inhibition of apoB secretion after 40 hrs by ELISA				Bioorg Med Chem Lett 21: 4150-4 (2011) Article DOI: 10.1016/j.bmcl.2011.05.099 BindingDB Entry DOI: 10.7270/Q2B27WCR
					More data for this Ligand-Target Pair
Microsomal triglyceride transfer protein large subunit (Homo sapiens (Human))	BDBM50184118 (4'-trifluoromethyl-biphenyl-2-carboxylic acid {2-m...) Show SMILES CCCNC(=O)[C@@H](NC(=O)c1ccc(NC(=O)c2ccccc2-c2ccc(cc2)C(F)(F)F)c(OC)c1)c1ccccc1 Show InChI InChI=1S/C33H30F3N3O4/c1-3-19-37-32(42)29(22-9-5-4-6-10-22)39-30(40)23-15-18-27(28(20-23)43-2)38-31(41)26-12-8-7-11-25(26)21-13-16-24(17-14-21)33(34,35)36/h4-18,20,29H,3,19H2,1-2H3,(H,37,42)(H,38,41)(H,39,40)/t29-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of MTP in canine liver microsomes				Bioorg Med Chem Lett 16: 3039-42 (2006) Article DOI: 10.1016/j.bmcl.2006.02.058 BindingDB Entry DOI: 10.7270/Q2D21X68
					More data for this Ligand-Target Pair
Microsomal triglyceride transfer protein large subunit (Homo sapiens (Human))	BDBM50391860 (CHEMBL2147283) Show SMILES CN(Cc1ccc(F)cc1)C(=O)[C@@H](NC(=O)c1ccc2nc(NC(=O)c3ccccc3-c3ccc(C)cc3)ccc2c1)c1ccccc1 |r| Show InChI InChI=1S/C40H33FN4O3/c1-26-12-16-28(17-13-26)33-10-6-7-11-34(33)39(47)43-36-23-19-30-24-31(18-22-35(30)42-36)38(46)44-37(29-8-4-3-5-9-29)40(48)45(2)25-27-14-20-32(41)21-15-27/h3-24,37H,25H2,1-2H3,(H,44,46)(H,42,43,47)/t37-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.20	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of MTP in human HepG2 cells assessed as inhibition of apoB secretion after 40 hrs by ELISA				Bioorg Med Chem Lett 21: 4150-4 (2011) Article DOI: 10.1016/j.bmcl.2011.05.099 BindingDB Entry DOI: 10.7270/Q2B27WCR
					More data for this Ligand-Target Pair
Microsomal triglyceride transfer protein large subunit (Homo sapiens (Human))	BDBM50184137 (4'-trifluoromethyl-biphenyl-2-carboxylic acid (4-{...) Show SMILES CCCN(CC)C(=O)[C@@H](NC(=O)c1ccc(NC(=O)c2ccccc2-c2ccc(cc2)C(F)(F)F)c(OC)c1)c1ccccc1 Show InChI InChI=1S/C35H34F3N3O4/c1-4-21-41(5-2)34(44)31(24-11-7-6-8-12-24)40-32(42)25-17-20-29(30(22-25)45-3)39-33(43)28-14-10-9-13-27(28)23-15-18-26(19-16-23)35(36,37)38/h6-20,22,31H,4-5,21H2,1-3H3,(H,39,43)(H,40,42)/t31-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.34	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of MTP in canine liver microsomes				Bioorg Med Chem Lett 16: 3039-42 (2006) Article DOI: 10.1016/j.bmcl.2006.02.058 BindingDB Entry DOI: 10.7270/Q2D21X68
					More data for this Ligand-Target Pair
Microsomal triglyceride transfer protein large subunit (Homo sapiens (Human))	BDBM50184127 (CHEMBL207443 | N-((S)-Phenyl-propylcarbamoyl-methy...) Show SMILES CCCNC(=O)[C@@H](NC(=O)c1ccc(NC(=O)c2ccccc2-c2ccc(cc2)C(F)(F)F)nc1)c1ccccc1 Show InChI InChI=1S/C31H27F3N4O3/c1-2-18-35-30(41)27(21-8-4-3-5-9-21)38-28(39)22-14-17-26(36-19-22)37-29(40)25-11-7-6-10-24(25)20-12-15-23(16-13-20)31(32,33)34/h3-17,19,27H,2,18H2,1H3,(H,35,41)(H,38,39)(H,36,37,40)/t27-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.53	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of MTP in canine liver microsomes				Bioorg Med Chem Lett 16: 3039-42 (2006) Article DOI: 10.1016/j.bmcl.2006.02.058 BindingDB Entry DOI: 10.7270/Q2D21X68
					More data for this Ligand-Target Pair
Microsomal triglyceride transfer protein large subunit (Homo sapiens (Human))	BDBM50204367 (CHEMBL410414 | dirlotapide) Show SMILES CN(Cc1ccccc1)C(=O)[C@@H](NC(=O)c1cc2cc(NC(=O)c3ccccc3-c3ccc(cc3)C(F)(F)F)ccc2n1C)c1ccccc1 |r| Show InChI InChI=1S/C40H33F3N4O3/c1-46(25-26-11-5-3-6-12-26)39(50)36(28-13-7-4-8-14-28)45-38(49)35-24-29-23-31(21-22-34(29)47(35)2)44-37(48)33-16-10-9-15-32(33)27-17-19-30(20-18-27)40(41,42)43/h3-24,36H,25H2,1-2H3,(H,44,48)(H,45,49)/t36-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.70	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of MTP in human HepG2 cells assessed as inhibition of apoB secretion after 40 hrs by ELISA				Bioorg Med Chem Lett 21: 4150-4 (2011) Article DOI: 10.1016/j.bmcl.2011.05.099 BindingDB Entry DOI: 10.7270/Q2B27WCR
					More data for this Ligand-Target Pair
Microsomal triglyceride transfer protein large subunit (Homo sapiens (Human))	BDBM50391878 (CHEMBL2147289) Show SMILES CCOc1ccc(cc1)-c1ccccc1C(=O)Nc1ccc2cc(ccc2n1)C(=O)N[C@H](C(=O)N(C)Cc1ccc(F)cc1)c1ccccc1 |r| Show InChI InChI=1S/C41H35FN4O4/c1-3-50-33-21-15-28(16-22-33)34-11-7-8-12-35(34)40(48)44-37-24-18-30-25-31(17-23-36(30)43-37)39(47)45-38(29-9-5-4-6-10-29)41(49)46(2)26-27-13-19-32(42)20-14-27/h4-25,38H,3,26H2,1-2H3,(H,45,47)(H,43,44,48)/t38-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.80	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of MTP in human HepG2 cells assessed as inhibition of apoB secretion after 40 hrs by ELISA				Bioorg Med Chem Lett 21: 4150-4 (2011) Article DOI: 10.1016/j.bmcl.2011.05.099 BindingDB Entry DOI: 10.7270/Q2B27WCR
					More data for this Ligand-Target Pair
Microsomal triglyceride transfer protein large subunit (Homo sapiens (Human))	BDBM50391859 (CHEMBL2147282) Show SMILES CN(Cc1ccc(F)cc1)C(=O)[C@@H](NC(=O)c1ccc2nc(NC(=O)c3ccccc3-c3ccccc3)ccc2c1)c1ccccc1 |r| Show InChI InChI=1S/C39H31FN4O3/c1-44(25-26-16-20-31(40)21-17-26)39(47)36(28-12-6-3-7-13-28)43-37(45)30-18-22-34-29(24-30)19-23-35(41-34)42-38(46)33-15-9-8-14-32(33)27-10-4-2-5-11-27/h2-24,36H,25H2,1H3,(H,43,45)(H,41,42,46)/t36-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.80	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of MTP in human HepG2 cells assessed as inhibition of apoB secretion after 40 hrs by ELISA				Bioorg Med Chem Lett 21: 4150-4 (2011) Article DOI: 10.1016/j.bmcl.2011.05.099 BindingDB Entry DOI: 10.7270/Q2B27WCR
					More data for this Ligand-Target Pair
Microsomal triglyceride transfer protein large subunit (Homo sapiens (Human))	BDBM50204367 (CHEMBL410414 | dirlotapide) Show SMILES CN(Cc1ccccc1)C(=O)[C@@H](NC(=O)c1cc2cc(NC(=O)c3ccccc3-c3ccc(cc3)C(F)(F)F)ccc2n1C)c1ccccc1 |r| Show InChI InChI=1S/C40H33F3N4O3/c1-46(25-26-11-5-3-6-12-26)39(50)36(28-13-7-4-8-14-28)45-38(49)35-24-29-23-31(21-22-34(29)47(35)2)44-37(48)33-16-10-9-15-32(33)27-17-19-30(20-18-27)40(41,42)43/h3-24,36H,25H2,1-2H3,(H,44,48)(H,45,49)/t36-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.90	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of MTP assessed as inhibition of apoB secretion from human HepG2 cells				Bioorg Med Chem Lett 17: 1996-9 (2007) Article DOI: 10.1016/j.bmcl.2007.01.018 BindingDB Entry DOI: 10.7270/Q2QC034Z
					More data for this Ligand-Target Pair
Microsomal triglyceride transfer protein large subunit (Homo sapiens (Human))	BDBM50184152 (4'-trifluoromethyl-biphenyl-2-carboxylic acid 4-[(...) Show SMILES FC(F)(F)c1ccc(cc1)-c1ccccc1C(=O)NCc1ccc(cc1)C(=O)N[C@H](C(=O)NCc1ccccc1)c1ccccc1 Show InChI InChI=1S/C37H30F3N3O3/c38-37(39,40)30-21-19-27(20-22-30)31-13-7-8-14-32(31)35(45)41-24-26-15-17-29(18-16-26)34(44)43-33(28-11-5-2-6-12-28)36(46)42-23-25-9-3-1-4-10-25/h1-22,33H,23-24H2,(H,41,45)(H,42,46)(H,43,44)/t33-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.97	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of MTP in canine liver microsomes				Bioorg Med Chem Lett 16: 3039-42 (2006) Article DOI: 10.1016/j.bmcl.2006.02.058 BindingDB Entry DOI: 10.7270/Q2D21X68
					More data for this Ligand-Target Pair
Microsomal triglyceride transfer protein large subunit (Homo sapiens (Human))	BDBM50391879 (CHEMBL2147288) Show SMILES COc1ccc(cc1)-c1ccccc1C(=O)Nc1ccc2cc(ccc2n1)C(=O)N[C@H](C(=O)N(C)Cc1ccc(F)cc1)c1ccccc1 |r| Show InChI InChI=1S/C40H33FN4O4/c1-45(25-26-12-18-31(41)19-13-26)40(48)37(28-8-4-3-5-9-28)44-38(46)30-16-22-35-29(24-30)17-23-36(42-35)43-39(47)34-11-7-6-10-33(34)27-14-20-32(49-2)21-15-27/h3-24,37H,25H2,1-2H3,(H,44,46)(H,42,43,47)/t37-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of MTP in human HepG2 cells assessed as inhibition of apoB secretion after 40 hrs by ELISA				Bioorg Med Chem Lett 21: 4150-4 (2011) Article DOI: 10.1016/j.bmcl.2011.05.099 BindingDB Entry DOI: 10.7270/Q2B27WCR
					More data for this Ligand-Target Pair
Microsomal triglyceride transfer protein large subunit (Homo sapiens (Human))	BDBM50184138 (4'-trifluoromethyl-biphenyl-2-carboxylic acid [2-m...) Show SMILES Cc1cc(ccc1NC(=O)c1ccccc1-c1ccc(cc1)C(F)(F)F)C(=O)N[C@H](C(=O)N1CCCC1)c1ccccc1 Show InChI InChI=1S/C34H30F3N3O3/c1-22-21-25(31(41)39-30(24-9-3-2-4-10-24)33(43)40-19-7-8-20-40)15-18-29(22)38-32(42)28-12-6-5-11-27(28)23-13-16-26(17-14-23)34(35,36)37/h2-6,9-18,21,30H,7-8,19-20H2,1H3,(H,38,42)(H,39,41)/t30-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.37	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of MTP in canine liver microsomes				Bioorg Med Chem Lett 16: 3039-42 (2006) Article DOI: 10.1016/j.bmcl.2006.02.058 BindingDB Entry DOI: 10.7270/Q2D21X68
					More data for this Ligand-Target Pair
Microsomal triglyceride transfer protein large subunit (Homo sapiens (Human))	BDBM50184147 (4'-trifluoromethyl-biphenyl-2-carboxylic acid {4-[...) Show SMILES Cc1cc(ccc1NC(=O)c1ccccc1-c1ccc(cc1)C(F)(F)F)C(=O)N[C@H](C(=O)NCc1ccccc1)c1ccccc1 Show InChI InChI=1S/C37H30F3N3O3/c1-24-22-28(34(44)43-33(27-12-6-3-7-13-27)36(46)41-23-25-10-4-2-5-11-25)18-21-32(24)42-35(45)31-15-9-8-14-30(31)26-16-19-29(20-17-26)37(38,39)40/h2-22,33H,23H2,1H3,(H,41,46)(H,42,45)(H,43,44)/t33-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.5	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of MTP in canine liver microsomes				Bioorg Med Chem Lett 16: 3039-42 (2006) Article DOI: 10.1016/j.bmcl.2006.02.058 BindingDB Entry DOI: 10.7270/Q2D21X68
					More data for this Ligand-Target Pair

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