Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Lymphocyte antigen 96 (Homo sapiens (Human)) | BDBM50239337 (CHEMBL4072822) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Milano-Bicocca Curated by ChEMBL | Assay Description Binding affinity to CD14/MD2 (unknown origin) expressed in HEK-Blue cells co-expressing TLR4 assessed as inhibition of LPS-induced TLR4 signaling pre... | J Med Chem 60: 4882-4892 (2017) Article DOI: 10.1021/acs.jmedchem.7b00095 BindingDB Entry DOI: 10.7270/Q2C24ZJ0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Toll-like receptor 4 (Homo sapiens (Human)) | BDBM50255625 (CHEMBL4070714) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents | Article PubMed | n/a | n/a | 630 | n/a | n/a | n/a | n/a | n/a | n/a |
Department of Biotechnology and Biosciences , University of Milano-Bicocca , Piazza della Scienza, 2 , 20126 Milano , Italy. Curated by ChEMBL | Assay Description Antagonist activity at human TLR4 expressed in HEK blue cells assessed as inhibition of LPS-induced NF-kappaB activation-mediated SEAP production pre... | J Med Chem 61: 2895-2909 (2018) Article DOI: 10.1021/acs.jmedchem.7b01803 BindingDB Entry DOI: 10.7270/Q21N83KC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lymphocyte antigen 96 (Homo sapiens (Human)) | BDBM50239340 (CHEMBL4081306) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 700 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Milano-Bicocca Curated by ChEMBL | Assay Description Binding affinity to CD14/MD2 (unknown origin) expressed in HEK-Blue cells co-expressing TLR4 assessed as inhibition of LPS-induced TLR4 signaling pre... | J Med Chem 60: 4882-4892 (2017) Article DOI: 10.1021/acs.jmedchem.7b00095 BindingDB Entry DOI: 10.7270/Q2C24ZJ0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Toll-like receptor 4 (Homo sapiens (Human)) | BDBM50255625 (CHEMBL4070714) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents | Article PubMed | n/a | n/a | 1.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Department of Biotechnology and Biosciences , University of Milano-Bicocca , Piazza della Scienza, 2 , 20126 Milano , Italy. Curated by ChEMBL | Assay Description Antagonist activity at human TLR4 expressed in mouse RAW blue cells assessed as inhibition of LPS-induced NF-kappaB activation-mediated SEAP producti... | J Med Chem 61: 2895-2909 (2018) Article DOI: 10.1021/acs.jmedchem.7b01803 BindingDB Entry DOI: 10.7270/Q21N83KC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Toll-like receptor 4 (Homo sapiens (Human)) | BDBM50255632 (CHEMBL4100044) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents | Article PubMed | n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Department of Biotechnology and Biosciences , University of Milano-Bicocca , Piazza della Scienza, 2 , 20126 Milano , Italy. Curated by ChEMBL | Assay Description Antagonist activity at human TLR4 expressed in HEK blue cells assessed as inhibition of LPS-induced NF-kappaB activation-mediated SEAP production pre... | J Med Chem 61: 2895-2909 (2018) Article DOI: 10.1021/acs.jmedchem.7b01803 BindingDB Entry DOI: 10.7270/Q21N83KC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Toll-like receptor 4 (Homo sapiens (Human)) | BDBM50255626 (CHEMBL4069693) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 5.45E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Department of Biotechnology and Biosciences , University of Milano-Bicocca , Piazza della Scienza, 2 , 20126 Milano , Italy. Curated by ChEMBL | Assay Description Antagonist activity at human TLR4 expressed in HEK blue cells assessed as inhibition of LPS-induced NF-kappaB activation-mediated SEAP production pre... | J Med Chem 61: 2895-2909 (2018) Article DOI: 10.1021/acs.jmedchem.7b01803 BindingDB Entry DOI: 10.7270/Q21N83KC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lymphocyte antigen 96 (Homo sapiens (Human)) | BDBM50239341 (CHEMBL4105554) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 5.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Milano-Bicocca Curated by ChEMBL | Assay Description Binding affinity to CD14/MD2 (unknown origin) expressed in HEK-Blue cells co-expressing TLR4 assessed as inhibition of LPS-induced TLR4 signaling pre... | J Med Chem 60: 4882-4892 (2017) Article DOI: 10.1021/acs.jmedchem.7b00095 BindingDB Entry DOI: 10.7270/Q2C24ZJ0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Toll-like receptor 4 (Homo sapiens (Human)) | BDBM50255632 (CHEMBL4100044) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents | Article PubMed | n/a | n/a | 7.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Department of Biotechnology and Biosciences , University of Milano-Bicocca , Piazza della Scienza, 2 , 20126 Milano , Italy. Curated by ChEMBL | Assay Description Antagonist activity at human TLR4 expressed in mouse RAW blue cells assessed as inhibition of LPS-induced NF-kappaB activation-mediated SEAP producti... | J Med Chem 61: 2895-2909 (2018) Article DOI: 10.1021/acs.jmedchem.7b01803 BindingDB Entry DOI: 10.7270/Q21N83KC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lymphocyte antigen 96 (Homo sapiens (Human)) | BDBM50239336 (CHEMBL4093531) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Milano-Bicocca Curated by ChEMBL | Assay Description Binding affinity to CD14/MD2 (unknown origin) expressed in HEK-Blue cells co-expressing TLR4 assessed as inhibition of LPS-induced TLR4 signaling pre... | J Med Chem 60: 4882-4892 (2017) Article DOI: 10.1021/acs.jmedchem.7b00095 BindingDB Entry DOI: 10.7270/Q2C24ZJ0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Toll-like receptor 4 (Homo sapiens (Human)) | BDBM50255626 (CHEMBL4069693) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 4.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Department of Biotechnology and Biosciences , University of Milano-Bicocca , Piazza della Scienza, 2 , 20126 Milano , Italy. Curated by ChEMBL | Assay Description Antagonist activity at human TLR4 expressed in mouse RAW blue cells assessed as inhibition of LPS-induced NF-kappaB activation-mediated SEAP producti... | J Med Chem 61: 2895-2909 (2018) Article DOI: 10.1021/acs.jmedchem.7b01803 BindingDB Entry DOI: 10.7270/Q21N83KC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lymphocyte antigen 96 (Homo sapiens (Human)) | BDBM50239339 (CHEMBL4091730) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 4.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Milano-Bicocca Curated by ChEMBL | Assay Description Binding affinity to CD14/MD2 (unknown origin) expressed in HEK-Blue cells co-expressing TLR4 assessed as inhibition of LPS-induced TLR4 signaling pre... | J Med Chem 60: 4882-4892 (2017) Article DOI: 10.1021/acs.jmedchem.7b00095 BindingDB Entry DOI: 10.7270/Q2C24ZJ0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lymphocyte antigen 96 (Homo sapiens (Human)) | BDBM50239338 (CHEMBL4070859) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 6.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Milano-Bicocca Curated by ChEMBL | Assay Description Binding affinity to CD14/MD2 (unknown origin) expressed in HEK-Blue cells co-expressing TLR4 assessed as inhibition of LPS-induced TLR4 signaling pre... | J Med Chem 60: 4882-4892 (2017) Article DOI: 10.1021/acs.jmedchem.7b00095 BindingDB Entry DOI: 10.7270/Q2C24ZJ0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Toll-like receptor 4/MD-2 (Homo sapiens (Human)) | BDBM50580155 (CHEMBL5084731) | PDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | 180 | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Binding affinity to NTA sensor chip immobilized recombinant human TLR4/MD2 assessed as dissociation constant by surface plasmon resonance analysis | Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00896 BindingDB Entry DOI: 10.7270/Q22N565D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lymphocyte antigen 96 (Homo sapiens (Human)) | BDBM50255633 (CHEMBL4091601) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | 6.70E+4 | n/a | n/a | n/a | n/a | n/a |
Department of Biotechnology and Biosciences , University of Milano-Bicocca , Piazza della Scienza, 2 , 20126 Milano , Italy. Curated by ChEMBL | Assay Description Binding to C-terminal His6-tagged human MD2 expressed in Pichia pastoris GS115 by surface plasmon resonance assay | J Med Chem 61: 2895-2909 (2018) Article DOI: 10.1021/acs.jmedchem.7b01803 BindingDB Entry DOI: 10.7270/Q21N83KC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lymphocyte antigen 96 (Homo sapiens (Human)) | BDBM50255626 (CHEMBL4069693) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | 2.20E+4 | n/a | n/a | n/a | n/a | n/a |
Department of Biotechnology and Biosciences , University of Milano-Bicocca , Piazza della Scienza, 2 , 20126 Milano , Italy. Curated by ChEMBL | Assay Description Binding to C-terminal His6-tagged human MD2 expressed in Pichia pastoris GS115 by surface plasmon resonance assay | J Med Chem 61: 2895-2909 (2018) Article DOI: 10.1021/acs.jmedchem.7b01803 BindingDB Entry DOI: 10.7270/Q21N83KC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lymphocyte antigen 96 (Homo sapiens (Human)) | BDBM50255625 (CHEMBL4070714) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem Patents | Article PubMed | n/a | n/a | n/a | 1.40E+4 | n/a | n/a | n/a | n/a | n/a |
Department of Biotechnology and Biosciences , University of Milano-Bicocca , Piazza della Scienza, 2 , 20126 Milano , Italy. Curated by ChEMBL | Assay Description Binding to C-terminal His6-tagged human MD2 expressed in Pichia pastoris GS115 by surface plasmon resonance assay | J Med Chem 61: 2895-2909 (2018) Article DOI: 10.1021/acs.jmedchem.7b01803 BindingDB Entry DOI: 10.7270/Q21N83KC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Toll-like receptor 4/MD-2 (Homo sapiens (Human)) | BDBM50580156 (CHEMBL5076109) | PDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | 570 | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Binding affinity to NTA sensor chip immobilized recombinant human TLR4/MD2 assessed as dissociation constant by surface plasmon resonance analysis | Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00896 BindingDB Entry DOI: 10.7270/Q22N565D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lymphocyte antigen 96 (Homo sapiens (Human)) | BDBM50255632 (CHEMBL4100044) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem Patents | Article PubMed | n/a | n/a | n/a | 3.00E+3 | n/a | n/a | n/a | n/a | n/a |
Department of Biotechnology and Biosciences , University of Milano-Bicocca , Piazza della Scienza, 2 , 20126 Milano , Italy. Curated by ChEMBL | Assay Description Binding to C-terminal His6-tagged human MD2 expressed in Pichia pastoris GS115 by surface plasmon resonance assay | J Med Chem 61: 2895-2909 (2018) Article DOI: 10.1021/acs.jmedchem.7b01803 BindingDB Entry DOI: 10.7270/Q21N83KC | |||||||||||
More data for this Ligand-Target Pair |