Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Calcitonin gene-related peptide type 1 receptor/Receptor activity-modifying protein 1 (Homo sapiens (Human)) | BDBM391716 (N-[(2R)-3-(7-methyl-1H- | US10300056, Example 1 | ...) | PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 0.0200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Sosei Heptares Curated by ChEMBL | Assay Description Displacement of [3H]telcagepant from recombinant human CLR/RAMP1 expressed in Sf21 insect cell membranes measured after 60 mins by microbeta scintill... | J Med Chem 63: 7906-7920 (2020) Article DOI: 10.1021/acs.jmedchem.0c01003 BindingDB Entry DOI: 10.7270/Q2NK3JKR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Receptor activity-modifying protein 1 (Homo sapiens (Human)) | BDBM391716 (N-[(2R)-3-(7-methyl-1H- | US10300056, Example 1 | ...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.0200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research | Assay Description Human CGRP receptors expressed (consisting of CRLR and RAMP1) in insect Sf21 cell membrane homogenates were re-suspended in the binding buffer (10 mM... | Bioorg Med Chem Lett 18: 3641-5 (2008) BindingDB Entry DOI: 10.7270/Q2T155ZX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Receptor activity-modifying protein 1 (Homo sapiens (Human)) | BDBM391716 (N-[(2R)-3-(7-methyl-1H- | US10300056, Example 1 | ...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.0200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Heptares Therapeutics Limited US Patent | Assay Description Radioligand binding assay. Human CGRP receptors expressed (consisting of CRLR and RAMP1) in insect Sf21 cell membrane homogenates were re-suspended i... | US Patent US10888561 (2021) BindingDB Entry DOI: 10.7270/Q28S4T1X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Receptor activity-modifying protein 1 (Homo sapiens (Human)) | BDBM391727 (N-[(2R)-1-({(2S)-3-{1-[2- | US10300056, Example 12...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.0250 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Heptares Therapeutics Limited US Patent | Assay Description Radioligand binding assay. Human CGRP receptors expressed (consisting of CRLR and RAMP1) in insect Sf21 cell membrane homogenates were re-suspended i... | US Patent US10888561 (2021) BindingDB Entry DOI: 10.7270/Q28S4T1X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Receptor activity-modifying protein 1 (Homo sapiens (Human)) | BDBM391727 (N-[(2R)-1-({(2S)-3-{1-[2- | US10300056, Example 12...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.0250 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research | Assay Description Human CGRP receptors expressed (consisting of CRLR and RAMP1) in insect Sf21 cell membrane homogenates were re-suspended in the binding buffer (10 mM... | Bioorg Med Chem Lett 18: 3641-5 (2008) BindingDB Entry DOI: 10.7270/Q2T155ZX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Calcitonin gene-related peptide type 1 receptor/Receptor activity-modifying protein 1 (Homo sapiens (Human)) | BDBM50539955 (CHEMBL4638938) | PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 0.0251 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Sosei Heptares Curated by ChEMBL | Assay Description Displacement of [3H]telcagepant from recombinant human CLR/RAMP1 expressed in Sf21 insect cell membranes measured after 60 mins by microbeta scintill... | J Med Chem 63: 7906-7920 (2020) Article DOI: 10.1021/acs.jmedchem.0c01003 BindingDB Entry DOI: 10.7270/Q2NK3JKR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Calcitonin gene-related peptide type 1 receptor/Receptor activity-modifying protein 1 (Homo sapiens (Human)) | BDBM391726 (N-[(2R)-3-(7-methyl-1H- | US10300056, Example 11 |...) | PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | 0.0316 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Sosei Heptares Curated by ChEMBL | Assay Description Displacement of [3H]telcagepant from recombinant human CLR/RAMP1 expressed in Sf21 insect cell membranes measured after 60 mins by microbeta scintill... | J Med Chem 63: 7906-7920 (2020) Article DOI: 10.1021/acs.jmedchem.0c01003 BindingDB Entry DOI: 10.7270/Q2NK3JKR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Calcitonin gene-related peptide type 1 receptor/Receptor activity-modifying protein 1 (Homo sapiens (Human)) | BDBM50184069 (CHEMBL207197 | N-((R)-1-((S)-6-amino-1-oxo-1-(4-(p...) | PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | 0.0316 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Sosei Heptares Curated by ChEMBL | Assay Description Displacement of [3H]telcagepant from recombinant human CLR/RAMP1 expressed in Sf21 insect cell membranes measured after 60 mins by microbeta scintill... | J Med Chem 63: 7906-7920 (2020) Article DOI: 10.1021/acs.jmedchem.0c01003 BindingDB Entry DOI: 10.7270/Q2NK3JKR | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Receptor activity-modifying protein 1 (Homo sapiens (Human)) | BDBM391726 (N-[(2R)-3-(7-methyl-1H- | US10300056, Example 11 |...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | US Patent | 0.0320 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Heptares Therapeutics Limited US Patent | Assay Description Radioligand binding assay. Human CGRP receptors expressed (consisting of CRLR and RAMP1) in insect Sf21 cell membrane homogenates were re-suspended i... | US Patent US10888561 (2021) BindingDB Entry DOI: 10.7270/Q28S4T1X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Receptor activity-modifying protein 1 (Homo sapiens (Human)) | BDBM391726 (N-[(2R)-3-(7-methyl-1H- | US10300056, Example 11 |...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | US Patent | 0.0320 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research | Assay Description Human CGRP receptors expressed (consisting of CRLR and RAMP1) in insect Sf21 cell membrane homogenates were re-suspended in the binding buffer (10 mM... | Bioorg Med Chem Lett 18: 3641-5 (2008) BindingDB Entry DOI: 10.7270/Q2T155ZX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Calcitonin gene-related peptide type 1 receptor/Receptor activity-modifying protein 1 (Homo sapiens (Human)) | BDBM391723 (3,5-dibromo-Nalpha-{[4-(2- | US10300056, Example 8...) | PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 0.0398 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Sosei Heptares Curated by ChEMBL | Assay Description Displacement of [3H]telcagepant from recombinant human CLR/RAMP1 expressed in Sf21 insect cell membranes measured after 60 mins by microbeta scintill... | J Med Chem 63: 7906-7920 (2020) Article DOI: 10.1021/acs.jmedchem.0c01003 BindingDB Entry DOI: 10.7270/Q2NK3JKR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Receptor activity-modifying protein 1 (Homo sapiens (Human)) | BDBM391722 (N-[(2R)-1-({(2S)-3-(1- | US10300056, Example 7 | U...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.0400 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research | Assay Description Human CGRP receptors expressed (consisting of CRLR and RAMP1) in insect Sf21 cell membrane homogenates were re-suspended in the binding buffer (10 mM... | Bioorg Med Chem Lett 18: 3641-5 (2008) BindingDB Entry DOI: 10.7270/Q2T155ZX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Receptor activity-modifying protein 1 (Homo sapiens (Human)) | BDBM391719 (N-[(2R)-3-(7-methyl-1H- | US10300056, Example 4 | ...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.0400 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research | Assay Description Human CGRP receptors expressed (consisting of CRLR and RAMP1) in insect Sf21 cell membrane homogenates were re-suspended in the binding buffer (10 mM... | Bioorg Med Chem Lett 18: 3641-5 (2008) BindingDB Entry DOI: 10.7270/Q2T155ZX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Receptor activity-modifying protein 1 (Homo sapiens (Human)) | BDBM391723 (3,5-dibromo-Nalpha-{[4-(2- | US10300056, Example 8...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.0400 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research | Assay Description Human CGRP receptors expressed (consisting of CRLR and RAMP1) in insect Sf21 cell membrane homogenates were re-suspended in the binding buffer (10 mM... | Bioorg Med Chem Lett 18: 3641-5 (2008) BindingDB Entry DOI: 10.7270/Q2T155ZX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Receptor activity-modifying protein 1 (Homo sapiens (Human)) | BDBM391722 (N-[(2R)-1-({(2S)-3-(1- | US10300056, Example 7 | U...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.0400 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Heptares Therapeutics Limited US Patent | Assay Description Radioligand binding assay. Human CGRP receptors expressed (consisting of CRLR and RAMP1) in insect Sf21 cell membrane homogenates were re-suspended i... | US Patent US10888561 (2021) BindingDB Entry DOI: 10.7270/Q28S4T1X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Receptor activity-modifying protein 1 (Homo sapiens (Human)) | BDBM391719 (N-[(2R)-3-(7-methyl-1H- | US10300056, Example 4 | ...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.0400 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Heptares Therapeutics Limited US Patent | Assay Description Radioligand binding assay. Human CGRP receptors expressed (consisting of CRLR and RAMP1) in insect Sf21 cell membrane homogenates were re-suspended i... | US Patent US10888561 (2021) BindingDB Entry DOI: 10.7270/Q28S4T1X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Receptor activity-modifying protein 1 (Homo sapiens (Human)) | BDBM391723 (3,5-dibromo-Nalpha-{[4-(2- | US10300056, Example 8...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.0400 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Heptares Therapeutics Limited US Patent | Assay Description Radioligand binding assay. Human CGRP receptors expressed (consisting of CRLR and RAMP1) in insect Sf21 cell membrane homogenates were re-suspended i... | US Patent US10888561 (2021) BindingDB Entry DOI: 10.7270/Q28S4T1X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
B1 bradykinin receptor (Homo sapiens (Human)) | BDBM50184183 (3,3'-difluoro-4'-{[5-(4-pyridin-4-yl-piperazine-1-...) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 0.0450 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Heptares Therapeutics Limited Curated by ChEMBL | Assay Description Antagonist activity at human bradykinin B1 receptor expressed in human HEK293 cells assessed as calcium flux by FLIPR assay | J Med Chem 54: 4283-311 (2011) Article DOI: 10.1021/jm200371q BindingDB Entry DOI: 10.7270/Q23N23RZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Coagulation factor X (Homo sapiens (Human)) | BDBM50080514 (3-[(R)-3-(7-Methoxy-naphthalene-2-sulfonylamino)-2...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 0.0470 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Rh£ne-Poulenc Rorer Curated by ChEMBL | Assay Description Compound was evaluated for the inhibition of human Coagulation factor Xa | J Med Chem 42: 3557-71 (1999) Article DOI: 10.1021/jm990040h BindingDB Entry DOI: 10.7270/Q2M04640 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Calcitonin gene-related peptide 1 (Homo sapiens (Human)) | BDBM311886 (N-[(2R)-1-[4-(1H-imidazol-2-yl)-1,4'-bipiperidin-1...) | PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.0500 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Heptares Therapeutics Limited US Patent | Assay Description Human CGRP receptors (consisting of CRLR and RAMP1) expressed in insect Sf21 cell membrane homogenates were re-suspended in the binding buffer (10 mM... | US Patent US10166226 (2019) BindingDB Entry DOI: 10.7270/Q28C9ZBC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Calcitonin gene-related peptide 1 (Homo sapiens (Human)) | BDBM312053 (5-{1'-[(2R)-3-(7-methyl-1H-indazol-5-yl)-2-({[4-(2...) | PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.0500 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Heptares Therapeutics Limited US Patent | Assay Description Human CGRP receptors (consisting of CRLR and RAMP1) expressed in insect Sf21 cell membrane homogenates were re-suspended in the binding buffer (10 mM... | US Patent US10166226 (2019) BindingDB Entry DOI: 10.7270/Q28C9ZBC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Receptor activity-modifying protein 1 (Homo sapiens (Human)) | BDBM391720 (3,5-dibromo-Nalpha-{[4-(2- | US10300056, Example 5...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.0630 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Heptares Therapeutics Limited US Patent | Assay Description Radioligand binding assay. Human CGRP receptors expressed (consisting of CRLR and RAMP1) in insect Sf21 cell membrane homogenates were re-suspended i... | US Patent US10888561 (2021) BindingDB Entry DOI: 10.7270/Q28S4T1X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Receptor activity-modifying protein 1 (Homo sapiens (Human)) | BDBM391725 (N-[(2R)-3-(7-methyl-1H- | US10300056, Example 10 |...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.0630 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Heptares Therapeutics Limited US Patent | Assay Description Radioligand binding assay. Human CGRP receptors expressed (consisting of CRLR and RAMP1) in insect Sf21 cell membrane homogenates were re-suspended i... | US Patent US10888561 (2021) BindingDB Entry DOI: 10.7270/Q28S4T1X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Calcitonin gene-related peptide 1 (Homo sapiens (Human)) | BDBM312050 (US10166226, Example 6 | ethyl 5-{1'-[(2R)-3-(7-met...) | PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.0630 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Heptares Therapeutics Limited US Patent | Assay Description Human CGRP receptors (consisting of CRLR and RAMP1) expressed in insect Sf21 cell membrane homogenates were re-suspended in the binding buffer (10 mM... | US Patent US10166226 (2019) BindingDB Entry DOI: 10.7270/Q28C9ZBC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Receptor activity-modifying protein 1 (Homo sapiens (Human)) | BDBM391720 (3,5-dibromo-Nalpha-{[4-(2- | US10300056, Example 5...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.0630 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research | Assay Description Human CGRP receptors expressed (consisting of CRLR and RAMP1) in insect Sf21 cell membrane homogenates were re-suspended in the binding buffer (10 mM... | Bioorg Med Chem Lett 18: 3641-5 (2008) BindingDB Entry DOI: 10.7270/Q2T155ZX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Receptor activity-modifying protein 1 (Homo sapiens (Human)) | BDBM391725 (N-[(2R)-3-(7-methyl-1H- | US10300056, Example 10 |...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.0630 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research | Assay Description Human CGRP receptors expressed (consisting of CRLR and RAMP1) in insect Sf21 cell membrane homogenates were re-suspended in the binding buffer (10 mM... | Bioorg Med Chem Lett 18: 3641-5 (2008) BindingDB Entry DOI: 10.7270/Q2T155ZX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Calcitonin gene-related peptide type 1 receptor/Receptor activity-modifying protein 1 (Homo sapiens (Human)) | BDBM391725 (N-[(2R)-3-(7-methyl-1H- | US10300056, Example 10 |...) | PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 0.0631 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Sosei Heptares Curated by ChEMBL | Assay Description Displacement of [3H]telcagepant from recombinant human CLR/RAMP1 expressed in Sf21 insect cell membranes measured after 60 mins by microbeta scintill... | J Med Chem 63: 7906-7920 (2020) Article DOI: 10.1021/acs.jmedchem.0c01003 BindingDB Entry DOI: 10.7270/Q2NK3JKR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Receptor activity-modifying protein 1 (Homo sapiens (Human)) | BDBM391718 (N-[(2R)-3-(7-methyl-1H- | US10300056, Example 3 | ...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.0790 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research | Assay Description Human CGRP receptors expressed (consisting of CRLR and RAMP1) in insect Sf21 cell membrane homogenates were re-suspended in the binding buffer (10 mM... | Bioorg Med Chem Lett 18: 3641-5 (2008) BindingDB Entry DOI: 10.7270/Q2T155ZX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Receptor activity-modifying protein 1 (Homo sapiens (Human)) | BDBM391729 (3,5-dibromo-Nalpha-[(2'-oxo- | US10300056, Example...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.0790 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Heptares Therapeutics Limited US Patent | Assay Description Radioligand binding assay. Human CGRP receptors expressed (consisting of CRLR and RAMP1) in insect Sf21 cell membrane homogenates were re-suspended i... | US Patent US10888561 (2021) BindingDB Entry DOI: 10.7270/Q28S4T1X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A2a (Homo sapiens (Human)) | BDBM616065 (US20230271964, Example 1-22) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | 0.0790 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details BindingDB Entry DOI: 10.7270/Q2251P9N | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Receptor activity-modifying protein 1 (Homo sapiens (Human)) | BDBM391724 (3,5-dibromo-Nalpha-{[4-(2- | US10300056, Example 9...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.0790 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research | Assay Description Human CGRP receptors expressed (consisting of CRLR and RAMP1) in insect Sf21 cell membrane homogenates were re-suspended in the binding buffer (10 mM... | Bioorg Med Chem Lett 18: 3641-5 (2008) BindingDB Entry DOI: 10.7270/Q2T155ZX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Receptor activity-modifying protein 1 (Homo sapiens (Human)) | BDBM391729 (3,5-dibromo-Nalpha-[(2'-oxo- | US10300056, Example...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.0790 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research | Assay Description Human CGRP receptors expressed (consisting of CRLR and RAMP1) in insect Sf21 cell membrane homogenates were re-suspended in the binding buffer (10 mM... | Bioorg Med Chem Lett 18: 3641-5 (2008) BindingDB Entry DOI: 10.7270/Q2T155ZX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A2a (Homo sapiens (Human)) | BDBM616103 (US20230271964, Example 1-60 | US20230271964, Examp...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | 0.0790 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details BindingDB Entry DOI: 10.7270/Q2251P9N | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Calcitonin gene-related peptide 1 (Homo sapiens (Human)) | BDBM311913 (N-[(2R)-1-[4-(4-methyl-1H-imidazol-5-yl)-1,4'-bipi...) | PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.0790 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Heptares Therapeutics Limited US Patent | Assay Description Human CGRP receptors (consisting of CRLR and RAMP1) expressed in insect Sf21 cell membrane homogenates were re-suspended in the binding buffer (10 mM... | US Patent US10166226 (2019) BindingDB Entry DOI: 10.7270/Q28C9ZBC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Receptor activity-modifying protein 1 (Homo sapiens (Human)) | BDBM391718 (N-[(2R)-3-(7-methyl-1H- | US10300056, Example 3 | ...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.0790 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Heptares Therapeutics Limited US Patent | Assay Description Radioligand binding assay. Human CGRP receptors expressed (consisting of CRLR and RAMP1) in insect Sf21 cell membrane homogenates were re-suspended i... | US Patent US10888561 (2021) BindingDB Entry DOI: 10.7270/Q28S4T1X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Receptor activity-modifying protein 1 (Homo sapiens (Human)) | BDBM391724 (3,5-dibromo-Nalpha-{[4-(2- | US10300056, Example 9...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.0790 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Heptares Therapeutics Limited US Patent | Assay Description Radioligand binding assay. Human CGRP receptors expressed (consisting of CRLR and RAMP1) in insect Sf21 cell membrane homogenates were re-suspended i... | US Patent US10888561 (2021) BindingDB Entry DOI: 10.7270/Q28S4T1X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Calcitonin gene-related peptide type 1 receptor/Receptor activity-modifying protein 1 (Homo sapiens (Human)) | BDBM391724 (3,5-dibromo-Nalpha-{[4-(2- | US10300056, Example 9...) | PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 0.0794 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Sosei Heptares Curated by ChEMBL | Assay Description Displacement of [3H]telcagepant from recombinant human CLR/RAMP1 expressed in Sf21 insect cell membranes measured after 60 mins by microbeta scintill... | J Med Chem 63: 7906-7920 (2020) Article DOI: 10.1021/acs.jmedchem.0c01003 BindingDB Entry DOI: 10.7270/Q2NK3JKR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Calcitonin gene-related peptide type 1 receptor/Receptor activity-modifying protein 1 (Homo sapiens (Human)) | BDBM391718 (N-[(2R)-3-(7-methyl-1H- | US10300056, Example 3 | ...) | PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 0.0794 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Sosei Heptares Curated by ChEMBL | Assay Description Displacement of [3H]telcagepant from recombinant human CLR/RAMP1 expressed in Sf21 insect cell membranes measured after 60 mins by microbeta scintill... | J Med Chem 63: 7906-7920 (2020) Article DOI: 10.1021/acs.jmedchem.0c01003 BindingDB Entry DOI: 10.7270/Q2NK3JKR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Receptor activity-modifying protein 1 (Homo sapiens (Human)) | BDBM391717 (US10300056, Example 2 | US10888561, Example 2 | te...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Heptares Therapeutics Limited US Patent | Assay Description Radioligand binding assay. Human CGRP receptors expressed (consisting of CRLR and RAMP1) in insect Sf21 cell membrane homogenates were re-suspended i... | US Patent US10888561 (2021) BindingDB Entry DOI: 10.7270/Q28S4T1X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A2a (Homo sapiens (Human)) | BDBM616110 (US20230271964, Example 1-67) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | 0.100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details BindingDB Entry DOI: 10.7270/Q2251P9N | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A2a (Homo sapiens (Human)) | BDBM616108 (US20230271964, Example 1-65) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | 0.100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details BindingDB Entry DOI: 10.7270/Q2251P9N | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Calcitonin gene-related peptide 1 (Homo sapiens (Human)) | BDBM312002 (N-{(2R)-3-(7-methyl-1H-indazol-5-yl)-1-[4-(4-methy...) | PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Heptares Therapeutics Limited US Patent | Assay Description Human CGRP receptors (consisting of CRLR and RAMP1) expressed in insect Sf21 cell membrane homogenates were re-suspended in the binding buffer (10 mM... | US Patent US10166226 (2019) BindingDB Entry DOI: 10.7270/Q28C9ZBC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Receptor activity-modifying protein 1 (Homo sapiens (Human)) | BDBM391721 (N-[(2R)-3-(7-methyl-1H- | US10300056, Example 6 | ...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Heptares Therapeutics Limited US Patent | Assay Description Radioligand binding assay. Human CGRP receptors expressed (consisting of CRLR and RAMP1) in insect Sf21 cell membrane homogenates were re-suspended i... | US Patent US10888561 (2021) BindingDB Entry DOI: 10.7270/Q28S4T1X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Receptor activity-modifying protein 1 (Homo sapiens (Human)) | BDBM391728 (3-(4-{(2S)-2-{[(2R)-3-(7- | US10300056, Example 13...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | KEGG PC cid PC sid UniChem | US Patent | 0.100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research | Assay Description Human CGRP receptors expressed (consisting of CRLR and RAMP1) in insect Sf21 cell membrane homogenates were re-suspended in the binding buffer (10 mM... | Bioorg Med Chem Lett 18: 3641-5 (2008) BindingDB Entry DOI: 10.7270/Q2T155ZX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Receptor activity-modifying protein 1 (Homo sapiens (Human)) | BDBM391721 (N-[(2R)-3-(7-methyl-1H- | US10300056, Example 6 | ...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research | Assay Description Human CGRP receptors expressed (consisting of CRLR and RAMP1) in insect Sf21 cell membrane homogenates were re-suspended in the binding buffer (10 mM... | Bioorg Med Chem Lett 18: 3641-5 (2008) BindingDB Entry DOI: 10.7270/Q2T155ZX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Receptor activity-modifying protein 1 (Homo sapiens (Human)) | BDBM391717 (US10300056, Example 2 | US10888561, Example 2 | te...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research | Assay Description Human CGRP receptors expressed (consisting of CRLR and RAMP1) in insect Sf21 cell membrane homogenates were re-suspended in the binding buffer (10 mM... | Bioorg Med Chem Lett 18: 3641-5 (2008) BindingDB Entry DOI: 10.7270/Q2T155ZX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A2a (Homo sapiens (Human)) | BDBM616097 (US20230271964, Example 1-54 | US20230271964, Examp...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | 0.100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details BindingDB Entry DOI: 10.7270/Q2251P9N | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Calcitonin gene-related peptide type 1 receptor/Receptor activity-modifying protein 1 (Homo sapiens (Human)) | BDBM50539954 (CHEMBL4636143) | PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 0.100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Sosei Heptares Curated by ChEMBL | Assay Description Displacement of [3H]telcagepant from recombinant human CLR/RAMP1 expressed in Sf21 insect cell membranes measured after 60 mins by microbeta scintill... | J Med Chem 63: 7906-7920 (2020) Article DOI: 10.1021/acs.jmedchem.0c01003 BindingDB Entry DOI: 10.7270/Q2NK3JKR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Calcitonin gene-related peptide 1 (Homo sapiens (Human)) | BDBM312052 (N-{(2R)-3-(7-methyl-1H-indazol-5-yl)-1-[4-(5-methy...) | PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Heptares Therapeutics Limited US Patent | Assay Description Human CGRP receptors (consisting of CRLR and RAMP1) expressed in insect Sf21 cell membrane homogenates were re-suspended in the binding buffer (10 mM... | US Patent US10166226 (2019) BindingDB Entry DOI: 10.7270/Q28C9ZBC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Receptor activity-modifying protein 1 (Homo sapiens (Human)) | BDBM391728 (3-(4-{(2S)-2-{[(2R)-3-(7- | US10300056, Example 13...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | KEGG PC cid PC sid UniChem | US Patent | 0.100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Heptares Therapeutics Limited US Patent | Assay Description Radioligand binding assay. Human CGRP receptors expressed (consisting of CRLR and RAMP1) in insect Sf21 cell membrane homogenates were re-suspended i... | US Patent US10888561 (2021) BindingDB Entry DOI: 10.7270/Q28S4T1X | |||||||||||
More data for this Ligand-Target Pair |
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