Found 223 hits with Last Name = 'materia' and Initial = 'l' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Alpha-1D adrenergic receptor
(Homo sapiens (Human)) | BDBM50023189
(CHEMBL3297829)Show SMILES COc1ccccc1N1CCN(CCn2c(=O)[nH]c3c4cc(NC(=O)CCCC(=O)N(C)Cc5ccccc5)ccc4sc3c2=O)CC1 Show InChI InChI=1S/C36H40N6O5S/c1-39(24-25-9-4-3-5-10-25)32(44)14-8-13-31(43)37-26-15-16-30-27(23-26)33-34(48-30)35(45)42(36(46)38-33)22-19-40-17-20-41(21-18-40)28-11-6-7-12-29(28)47-2/h3-7,9-12,15-16,23H,8,13-14,17-22,24H2,1-2H3,(H,37,43)(H,38,46) | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 0.0562 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Catania
Curated by ChEMBL
| Assay Description
Displacement of [125I]BE2254 from human alpha1d receptor expressed in HEK293 cells |
Eur J Med Chem 83: 419-32 (2014)
Article DOI: 10.1016/j.ejmech.2014.06.057
BindingDB Entry DOI: 10.7270/Q2639RBH |
More data for this
Ligand-Target Pair | |
Alpha-1D adrenergic receptor
(Homo sapiens (Human)) | BDBM50143697
(8-{2-[4-(2,5-Dichloro-phenyl)-piperazin-1-yl]-ethy...)Show SMILES Clc1ccc(Cl)c(c1)N1CCN(CCN2C(=O)CC3(CCCC3)CC2=O)CC1 Show InChI InChI=1S/C21H27Cl2N3O2/c22-16-3-4-17(23)18(13-16)25-10-7-24(8-11-25)9-12-26-19(27)14-21(15-20(26)28)5-1-2-6-21/h3-4,13H,1-2,5-12,14-15H2 | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 0.129 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Catania
Curated by ChEMBL
| Assay Description
Displacement of [125I]BE-2254 from human adrenergic Alpha-1D receptor expressed in HEK293 cells |
Eur J Med Chem 46: 2676-90 (2011)
Article DOI: 10.1016/j.ejmech.2011.03.054
BindingDB Entry DOI: 10.7270/Q25140G9 |
More data for this
Ligand-Target Pair | |
Alpha-1D adrenergic receptor
(Homo sapiens (Human)) | BDBM50023188
(CHEMBL3298750)Show SMILES COc1ccccc1N1CCN(CCn2c(=O)[nH]c3c4cc(NC(=O)CCCC(=O)NCc5ccccc5)ccc4sc3c2=O)CC1 Show InChI InChI=1S/C35H38N6O5S/c1-46-28-11-6-5-10-27(28)40-19-16-39(17-20-40)18-21-41-34(44)33-32(38-35(41)45)26-22-25(14-15-29(26)47-33)37-31(43)13-7-12-30(42)36-23-24-8-3-2-4-9-24/h2-6,8-11,14-15,22H,7,12-13,16-21,23H2,1H3,(H,36,42)(H,37,43)(H,38,45) | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 0.141 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Catania
Curated by ChEMBL
| Assay Description
Displacement of [125I]BE2254 from human alpha1d receptor expressed in HEK293 cells |
Eur J Med Chem 83: 419-32 (2014)
Article DOI: 10.1016/j.ejmech.2014.06.057
BindingDB Entry DOI: 10.7270/Q2639RBH |
More data for this
Ligand-Target Pair | |
Alpha-1D adrenergic receptor
(Homo sapiens (Human)) | BDBM50476083
(CHEMBL220515)Show SMILES COc1ccc(Cl)cc1N1CCN(CCn2c(C)nc3c4ccccc4[nH]c3c2=O)CC1 Show InChI InChI=1S/C24H26ClN5O2/c1-16-26-22-18-5-3-4-6-19(18)27-23(22)24(31)30(16)14-11-28-9-12-29(13-10-28)20-15-17(25)7-8-21(20)32-2/h3-8,15,27H,9-14H2,1-2H3 | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 0.166 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Catania
Curated by ChEMBL
| Assay Description
Displacement of [125I]BE2254 from human cloned adrenergic alpha 1D receptor expressed in HEK293 cells |
Bioorg Med Chem Lett 16: 6200-3 (2006)
Article DOI: 10.1016/j.bmcl.2006.09.034
BindingDB Entry DOI: 10.7270/Q2GT5QZC |
More data for this
Ligand-Target Pair | |
Alpha-1A adrenergic receptor
(Homo sapiens (Human)) | BDBM50006952
(2-{2-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-ethyl}-...)Show SMILES COc1ccccc1N1CCN(CCn2c(=O)[nH]c3c4ccccc4[nH]c3c2=O)CC1 Show InChI InChI=1S/C23H25N5O3/c1-31-19-9-5-4-8-18(19)27-13-10-26(11-14-27)12-15-28-22(29)21-20(25-23(28)30)16-6-2-3-7-17(16)24-21/h2-9,24H,10-15H2,1H3,(H,25,30) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 0.269 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Catania
Curated by ChEMBL
| Assay Description
Displacement of [125I]BE-2254 from human adrenergic alpha1A receptor expressed in HEK293 cells |
Eur J Med Chem 46: 2676-90 (2011)
Article DOI: 10.1016/j.ejmech.2011.03.054
BindingDB Entry DOI: 10.7270/Q25140G9 |
More data for this
Ligand-Target Pair | |
Alpha-1A adrenergic receptor
(Homo sapiens (Human)) | BDBM50006952
(2-{2-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-ethyl}-...)Show SMILES COc1ccccc1N1CCN(CCn2c(=O)[nH]c3c4ccccc4[nH]c3c2=O)CC1 Show InChI InChI=1S/C23H25N5O3/c1-31-19-9-5-4-8-18(19)27-13-10-26(11-14-27)12-15-28-22(29)21-20(25-23(28)30)16-6-2-3-7-17(16)24-21/h2-9,24H,10-15H2,1H3,(H,25,30) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 0.269 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Catania
Curated by ChEMBL
| Assay Description
Binding affinity to adrenergic alpha1A receptor |
Eur J Med Chem 46: 2676-90 (2011)
Article DOI: 10.1016/j.ejmech.2011.03.054
BindingDB Entry DOI: 10.7270/Q25140G9 |
More data for this
Ligand-Target Pair | |
Alpha-1A adrenergic receptor
(Homo sapiens (Human)) | BDBM50006952
(2-{2-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-ethyl}-...)Show SMILES COc1ccccc1N1CCN(CCn2c(=O)[nH]c3c4ccccc4[nH]c3c2=O)CC1 Show InChI InChI=1S/C23H25N5O3/c1-31-19-9-5-4-8-18(19)27-13-10-26(11-14-27)12-15-28-22(29)21-20(25-23(28)30)16-6-2-3-7-17(16)24-21/h2-9,24H,10-15H2,1H3,(H,25,30) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 0.288 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Catania
Curated by ChEMBL
| Assay Description
Displacement of [125I]BE2254 from human cloned adrenergic alpha 1A receptor expressed in HEK293 cells |
Bioorg Med Chem Lett 16: 6200-3 (2006)
Article DOI: 10.1016/j.bmcl.2006.09.034
BindingDB Entry DOI: 10.7270/Q2GT5QZC |
More data for this
Ligand-Target Pair | |
Alpha-1A adrenergic receptor
(Homo sapiens (Human)) | BDBM50023188
(CHEMBL3298750)Show SMILES COc1ccccc1N1CCN(CCn2c(=O)[nH]c3c4cc(NC(=O)CCCC(=O)NCc5ccccc5)ccc4sc3c2=O)CC1 Show InChI InChI=1S/C35H38N6O5S/c1-46-28-11-6-5-10-27(28)40-19-16-39(17-20-40)18-21-41-34(44)33-32(38-35(41)45)26-22-25(14-15-29(26)47-33)37-31(43)13-7-12-30(42)36-23-24-8-3-2-4-9-24/h2-6,8-11,14-15,22H,7,12-13,16-21,23H2,1H3,(H,36,42)(H,37,43)(H,38,45) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 0.324 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Catania
Curated by ChEMBL
| Assay Description
Displacement of [125I]BE2254 from human alpha1a receptor expressed in HEK293 cells |
Eur J Med Chem 83: 419-32 (2014)
Article DOI: 10.1016/j.ejmech.2014.06.057
BindingDB Entry DOI: 10.7270/Q2639RBH |
More data for this
Ligand-Target Pair | |
Alpha-1D adrenergic receptor
(Homo sapiens (Human)) | BDBM50006952
(2-{2-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-ethyl}-...)Show SMILES COc1ccccc1N1CCN(CCn2c(=O)[nH]c3c4ccccc4[nH]c3c2=O)CC1 Show InChI InChI=1S/C23H25N5O3/c1-31-19-9-5-4-8-18(19)27-13-10-26(11-14-27)12-15-28-22(29)21-20(25-23(28)30)16-6-2-3-7-17(16)24-21/h2-9,24H,10-15H2,1H3,(H,25,30) | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 0.363 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Catania
Curated by ChEMBL
| Assay Description
Displacement of [125I]BE-2254 from human adrenergic Alpha-1D receptor expressed in HEK293 cells |
Eur J Med Chem 46: 2676-90 (2011)
Article DOI: 10.1016/j.ejmech.2011.03.054
BindingDB Entry DOI: 10.7270/Q25140G9 |
More data for this
Ligand-Target Pair | |
Alpha-1D adrenergic receptor
(Homo sapiens (Human)) | BDBM50006952
(2-{2-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-ethyl}-...)Show SMILES COc1ccccc1N1CCN(CCn2c(=O)[nH]c3c4ccccc4[nH]c3c2=O)CC1 Show InChI InChI=1S/C23H25N5O3/c1-31-19-9-5-4-8-18(19)27-13-10-26(11-14-27)12-15-28-22(29)21-20(25-23(28)30)16-6-2-3-7-17(16)24-21/h2-9,24H,10-15H2,1H3,(H,25,30) | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 0.363 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Catania
Curated by ChEMBL
| Assay Description
Binding affinity to adrenergic Alpha-1D receptor |
Eur J Med Chem 46: 2676-90 (2011)
Article DOI: 10.1016/j.ejmech.2011.03.054
BindingDB Entry DOI: 10.7270/Q25140G9 |
More data for this
Ligand-Target Pair | |
Alpha-1D adrenergic receptor
(Homo sapiens (Human)) | BDBM50006952
(2-{2-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-ethyl}-...)Show SMILES COc1ccccc1N1CCN(CCn2c(=O)[nH]c3c4ccccc4[nH]c3c2=O)CC1 Show InChI InChI=1S/C23H25N5O3/c1-31-19-9-5-4-8-18(19)27-13-10-26(11-14-27)12-15-28-22(29)21-20(25-23(28)30)16-6-2-3-7-17(16)24-21/h2-9,24H,10-15H2,1H3,(H,25,30) | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 0.363 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Catania
Curated by ChEMBL
| Assay Description
Displacement of [125I]BE2254 from human cloned adrenergic alpha 1D receptor expressed in HEK293 cells |
Bioorg Med Chem Lett 16: 6200-3 (2006)
Article DOI: 10.1016/j.bmcl.2006.09.034
BindingDB Entry DOI: 10.7270/Q2GT5QZC |
More data for this
Ligand-Target Pair | |
Alpha-1D adrenergic receptor
(Homo sapiens (Human)) | BDBM50023187
(CHEMBL3298749)Show SMILES COc1ccccc1N1CCN(CCn2c(=O)[nH]c3c4cc(NC(=O)CCC(=O)NCc5ccccc5)ccc4sc3c2=O)CC1 Show InChI InChI=1S/C34H36N6O5S/c1-45-27-10-6-5-9-26(27)39-18-15-38(16-19-39)17-20-40-33(43)32-31(37-34(40)44)25-21-24(11-12-28(25)46-32)36-30(42)14-13-29(41)35-22-23-7-3-2-4-8-23/h2-12,21H,13-20,22H2,1H3,(H,35,41)(H,36,42)(H,37,44) | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 0.372 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Catania
Curated by ChEMBL
| Assay Description
Displacement of [125I]BE2254 from human alpha1d receptor expressed in HEK293 cells |
Eur J Med Chem 83: 419-32 (2014)
Article DOI: 10.1016/j.ejmech.2014.06.057
BindingDB Entry DOI: 10.7270/Q2639RBH |
More data for this
Ligand-Target Pair | |
Alpha-1D adrenergic receptor
(Homo sapiens (Human)) | BDBM50023200
(CHEMBL220221)Show SMILES COc1ccccc1N1CCN(CCn2c(C)nc3c4ccccc4sc3c2=O)CC1 Show InChI InChI=1S/C24H26N4O2S/c1-17-25-22-18-7-3-6-10-21(18)31-23(22)24(29)28(17)16-13-26-11-14-27(15-12-26)19-8-4-5-9-20(19)30-2/h3-10H,11-16H2,1-2H3 | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 0.398 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Catania
Curated by ChEMBL
| Assay Description
Displacement of [125I]BE2254 from human alpha1d receptor expressed in HEK293 cells |
Eur J Med Chem 83: 419-32 (2014)
Article DOI: 10.1016/j.ejmech.2014.06.057
BindingDB Entry DOI: 10.7270/Q2639RBH |
More data for this
Ligand-Target Pair | |
Alpha-1D adrenergic receptor
(Homo sapiens (Human)) | BDBM50023200
(CHEMBL220221)Show SMILES COc1ccccc1N1CCN(CCn2c(C)nc3c4ccccc4sc3c2=O)CC1 Show InChI InChI=1S/C24H26N4O2S/c1-17-25-22-18-7-3-6-10-21(18)31-23(22)24(29)28(17)16-13-26-11-14-27(15-12-26)19-8-4-5-9-20(19)30-2/h3-10H,11-16H2,1-2H3 | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 0.398 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Catania
Curated by ChEMBL
| Assay Description
Displacement of [125I]BE2254 from human cloned adrenergic alpha 1D receptor expressed in HEK293 cells |
Bioorg Med Chem Lett 16: 6200-3 (2006)
Article DOI: 10.1016/j.bmcl.2006.09.034
BindingDB Entry DOI: 10.7270/Q2GT5QZC |
More data for this
Ligand-Target Pair | |
Alpha-1D adrenergic receptor
(Homo sapiens (Human)) | BDBM50476084
(CHEMBL99142)Show SMILES COc1ccccc1N1CCN(CCn2c(C)nc3c4ccccc4nc3c2O)CC1 Show InChI InChI=1S/C24H27N5O2/c1-17-25-22-18-7-3-4-8-19(18)26-23(22)24(30)29(17)16-13-27-11-14-28(15-12-27)20-9-5-6-10-21(20)31-2/h3-10,30H,11-16H2,1-2H3 | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 0.407 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Catania
Curated by ChEMBL
| Assay Description
Displacement of [125I]BE2254 from human cloned adrenergic alpha 1D receptor expressed in HEK293 cells |
Bioorg Med Chem Lett 16: 6200-3 (2006)
Article DOI: 10.1016/j.bmcl.2006.09.034
BindingDB Entry DOI: 10.7270/Q2GT5QZC |
More data for this
Ligand-Target Pair | |
Alpha-1D adrenergic receptor
(Homo sapiens (Human)) | BDBM50418765
(CHEMBL1796046)Show SMILES COc1ccccc1N1CCN(CCCCN2C(=O)CC(C)(CC2=O)c2ccccc2)CC1 Show InChI InChI=1S/C27H35N3O3/c1-27(22-10-4-3-5-11-22)20-25(31)30(26(32)21-27)15-9-8-14-28-16-18-29(19-17-28)23-12-6-7-13-24(23)33-2/h3-7,10-13H,8-9,14-21H2,1-2H3 | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 0.501 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Catania
Curated by ChEMBL
| Assay Description
Antagonist activity against human cloned adrenergic Alpha-1D receptor expressed in HEK293 cells assessed as inhibition of norepinephrine-induced [3H]... |
Eur J Med Chem 46: 2676-90 (2011)
Article DOI: 10.1016/j.ejmech.2011.03.054
BindingDB Entry DOI: 10.7270/Q25140G9 |
More data for this
Ligand-Target Pair | |
Alpha-1D adrenergic receptor
(Homo sapiens (Human)) | BDBM50023183
(CHEMBL3298745)Show SMILES COc1ccccc1N1CCN(CCn2c(=O)[nH]c3c4cc(NC(=O)c5ccccc5)ccc4sc3c2=O)CC1 Show InChI InChI=1S/C30H29N5O4S/c1-39-24-10-6-5-9-23(24)34-16-13-33(14-17-34)15-18-35-29(37)27-26(32-30(35)38)22-19-21(11-12-25(22)40-27)31-28(36)20-7-3-2-4-8-20/h2-12,19H,13-18H2,1H3,(H,31,36)(H,32,38) | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 0.575 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Catania
Curated by ChEMBL
| Assay Description
Displacement of [125I]BE2254 from human alpha1d receptor expressed in HEK293 cells |
Eur J Med Chem 83: 419-32 (2014)
Article DOI: 10.1016/j.ejmech.2014.06.057
BindingDB Entry DOI: 10.7270/Q2639RBH |
More data for this
Ligand-Target Pair | |
Alpha-1D adrenergic receptor
(Homo sapiens (Human)) | BDBM50023196
(CHEMBL3298023)Show SMILES COc1ccccc1N1CCN(CCn2c(C)nc3c4cc(NC(=O)CCCC(=O)NCCc5ccccc5)ccc4sc3c2=O)CC1 Show InChI InChI=1S/C37H42N6O4S/c1-26-39-35-29-25-28(40-34(45)14-8-13-33(44)38-18-17-27-9-4-3-5-10-27)15-16-32(29)48-36(35)37(46)43(26)24-21-41-19-22-42(23-20-41)30-11-6-7-12-31(30)47-2/h3-7,9-12,15-16,25H,8,13-14,17-24H2,1-2H3,(H,38,44)(H,40,45) | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 0.759 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Catania
Curated by ChEMBL
| Assay Description
Displacement of [125I]BE2254 from human alpha1d receptor expressed in HEK293 cells |
Eur J Med Chem 83: 419-32 (2014)
Article DOI: 10.1016/j.ejmech.2014.06.057
BindingDB Entry DOI: 10.7270/Q2639RBH |
More data for this
Ligand-Target Pair | |
Alpha-1B adrenergic receptor
(Homo sapiens (Human)) | BDBM50023188
(CHEMBL3298750)Show SMILES COc1ccccc1N1CCN(CCn2c(=O)[nH]c3c4cc(NC(=O)CCCC(=O)NCc5ccccc5)ccc4sc3c2=O)CC1 Show InChI InChI=1S/C35H38N6O5S/c1-46-28-11-6-5-10-27(28)40-19-16-39(17-20-40)18-21-41-34(44)33-32(38-35(41)45)26-22-25(14-15-29(26)47-33)37-31(43)13-7-12-30(42)36-23-24-8-3-2-4-9-24/h2-6,8-11,14-15,22H,7,12-13,16-21,23H2,1H3,(H,36,42)(H,37,43)(H,38,45) | UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 0.832 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Catania
Curated by ChEMBL
| Assay Description
Displacement of [125I]BE2254 from human alpha1b receptor expressed in HEK293 cells |
Eur J Med Chem 83: 419-32 (2014)
Article DOI: 10.1016/j.ejmech.2014.06.057
BindingDB Entry DOI: 10.7270/Q2639RBH |
More data for this
Ligand-Target Pair | |
Alpha-1D adrenergic receptor
(Homo sapiens (Human)) | BDBM50476087
(CHEMBL222896)Show SMILES COc1ccc(Cl)cc1N1CCN(CCn2c(C)nc3c4ccccc4sc3c2=O)CC1 Show InChI InChI=1S/C24H25ClN4O2S/c1-16-26-22-18-5-3-4-6-21(18)32-23(22)24(30)29(16)14-11-27-9-12-28(13-10-27)19-15-17(25)7-8-20(19)31-2/h3-8,15H,9-14H2,1-2H3 | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 0.832 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Catania
Curated by ChEMBL
| Assay Description
Displacement of [125I]BE2254 from human cloned adrenergic alpha 1D receptor expressed in HEK293 cells |
Bioorg Med Chem Lett 16: 6200-3 (2006)
Article DOI: 10.1016/j.bmcl.2006.09.034
BindingDB Entry DOI: 10.7270/Q2GT5QZC |
More data for this
Ligand-Target Pair | |
Alpha-1A adrenergic receptor
(Homo sapiens (Human)) | BDBM50023196
(CHEMBL3298023)Show SMILES COc1ccccc1N1CCN(CCn2c(C)nc3c4cc(NC(=O)CCCC(=O)NCCc5ccccc5)ccc4sc3c2=O)CC1 Show InChI InChI=1S/C37H42N6O4S/c1-26-39-35-29-25-28(40-34(45)14-8-13-33(44)38-18-17-27-9-4-3-5-10-27)15-16-32(29)48-36(35)37(46)43(26)24-21-41-19-22-42(23-20-41)30-11-6-7-12-31(30)47-2/h3-7,9-12,15-16,25H,8,13-14,17-24H2,1-2H3,(H,38,44)(H,40,45) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 0.912 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Catania
Curated by ChEMBL
| Assay Description
Displacement of [125I]BE2254 from human alpha1a receptor expressed in HEK293 cells |
Eur J Med Chem 83: 419-32 (2014)
Article DOI: 10.1016/j.ejmech.2014.06.057
BindingDB Entry DOI: 10.7270/Q2639RBH |
More data for this
Ligand-Target Pair | |
Alpha-1D adrenergic receptor
(Homo sapiens (Human)) | BDBM50023184
(CHEMBL3298746)Show SMILES COc1ccccc1N1CCN(CCn2c(=O)[nH]c3c4cc(NC(=O)Cc5ccccc5)ccc4sc3c2=O)CC1 Show InChI InChI=1S/C31H31N5O4S/c1-40-25-10-6-5-9-24(25)35-16-13-34(14-17-35)15-18-36-30(38)29-28(33-31(36)39)23-20-22(11-12-26(23)41-29)32-27(37)19-21-7-3-2-4-8-21/h2-12,20H,13-19H2,1H3,(H,32,37)(H,33,39) | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 0.912 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Catania
Curated by ChEMBL
| Assay Description
Displacement of [125I]BE2254 from human alpha1d receptor expressed in HEK293 cells |
Eur J Med Chem 83: 419-32 (2014)
Article DOI: 10.1016/j.ejmech.2014.06.057
BindingDB Entry DOI: 10.7270/Q2639RBH |
More data for this
Ligand-Target Pair | |
Alpha-1A adrenergic receptor
(Homo sapiens (Human)) | BDBM50023189
(CHEMBL3297829)Show SMILES COc1ccccc1N1CCN(CCn2c(=O)[nH]c3c4cc(NC(=O)CCCC(=O)N(C)Cc5ccccc5)ccc4sc3c2=O)CC1 Show InChI InChI=1S/C36H40N6O5S/c1-39(24-25-9-4-3-5-10-25)32(44)14-8-13-31(43)37-26-15-16-30-27(23-26)33-34(48-30)35(45)42(36(46)38-33)22-19-40-17-20-41(21-18-40)28-11-6-7-12-29(28)47-2/h3-7,9-12,15-16,23H,8,13-14,17-22,24H2,1-2H3,(H,37,43)(H,38,46) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 0.933 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Catania
Curated by ChEMBL
| Assay Description
Displacement of [125I]BE2254 from human alpha1a receptor expressed in HEK293 cells |
Eur J Med Chem 83: 419-32 (2014)
Article DOI: 10.1016/j.ejmech.2014.06.057
BindingDB Entry DOI: 10.7270/Q2639RBH |
More data for this
Ligand-Target Pair | |
Alpha-1A adrenergic receptor
(Homo sapiens (Human)) | BDBM50023197
(CHEMBL3298024)Show SMILES COc1ccccc1N1CCN(CCn2c(C)nc3c4cc(NC(=O)CCCNC(=O)Cc5ccccc5)ccc4sc3c2=O)CC1 Show InChI InChI=1S/C36H40N6O4S/c1-25-38-34-28-24-27(39-32(43)13-8-16-37-33(44)23-26-9-4-3-5-10-26)14-15-31(28)47-35(34)36(45)42(25)22-19-40-17-20-41(21-18-40)29-11-6-7-12-30(29)46-2/h3-7,9-12,14-15,24H,8,13,16-23H2,1-2H3,(H,37,44)(H,39,43) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Catania
Curated by ChEMBL
| Assay Description
Displacement of [125I]BE2254 from human alpha1a receptor expressed in HEK293 cells |
Eur J Med Chem 83: 419-32 (2014)
Article DOI: 10.1016/j.ejmech.2014.06.057
BindingDB Entry DOI: 10.7270/Q2639RBH |
More data for this
Ligand-Target Pair | |
Alpha-1D adrenergic receptor
(Homo sapiens (Human)) | BDBM50023190
(CHEMBL3298017)Show SMILES COc1ccccc1N1CCN(CCn2c(=O)[nH]c3c4cc(NC(=O)CCCC(=O)NCCc5ccccc5)ccc4sc3c2=O)CC1 Show InChI InChI=1S/C36H40N6O5S/c1-47-29-11-6-5-10-28(29)41-21-18-40(19-22-41)20-23-42-35(45)34-33(39-36(42)46)27-24-26(14-15-30(27)48-34)38-32(44)13-7-12-31(43)37-17-16-25-8-3-2-4-9-25/h2-6,8-11,14-15,24H,7,12-13,16-23H2,1H3,(H,37,43)(H,38,44)(H,39,46) | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Catania
Curated by ChEMBL
| Assay Description
Displacement of [125I]BE2254 from human alpha1d receptor expressed in HEK293 cells |
Eur J Med Chem 83: 419-32 (2014)
Article DOI: 10.1016/j.ejmech.2014.06.057
BindingDB Entry DOI: 10.7270/Q2639RBH |
More data for this
Ligand-Target Pair | |
Alpha-1D adrenergic receptor
(Homo sapiens (Human)) | BDBM50026917
(8-(2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)-8-a...)Show SMILES COc1ccccc1N1CCN(CCN2C(=O)CC3(CCCC3)CC2=O)CC1 Show InChI InChI=1S/C22H31N3O3/c1-28-19-7-3-2-6-18(19)24-13-10-23(11-14-24)12-15-25-20(26)16-22(17-21(25)27)8-4-5-9-22/h2-3,6-7H,4-5,8-17H2,1H3 | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 1.05 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Catania
Curated by ChEMBL
| Assay Description
Binding affinity to adrenergic Alpha-1D receptor |
Eur J Med Chem 46: 2676-90 (2011)
Article DOI: 10.1016/j.ejmech.2011.03.054
BindingDB Entry DOI: 10.7270/Q25140G9 |
More data for this
Ligand-Target Pair | |
Alpha-1A adrenergic receptor
(Homo sapiens (Human)) | BDBM50023187
(CHEMBL3298749)Show SMILES COc1ccccc1N1CCN(CCn2c(=O)[nH]c3c4cc(NC(=O)CCC(=O)NCc5ccccc5)ccc4sc3c2=O)CC1 Show InChI InChI=1S/C34H36N6O5S/c1-45-27-10-6-5-9-26(27)39-18-15-38(16-19-39)17-20-40-33(43)32-31(37-34(40)44)25-21-24(11-12-28(25)46-32)36-30(42)14-13-29(41)35-22-23-7-3-2-4-8-23/h2-12,21H,13-20,22H2,1H3,(H,35,41)(H,36,42)(H,37,44) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 1.10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Catania
Curated by ChEMBL
| Assay Description
Displacement of [125I]BE2254 from human alpha1a receptor expressed in HEK293 cells |
Eur J Med Chem 83: 419-32 (2014)
Article DOI: 10.1016/j.ejmech.2014.06.057
BindingDB Entry DOI: 10.7270/Q2639RBH |
More data for this
Ligand-Target Pair | |
Alpha-1A adrenergic receptor
(Homo sapiens (Human)) | BDBM50023183
(CHEMBL3298745)Show SMILES COc1ccccc1N1CCN(CCn2c(=O)[nH]c3c4cc(NC(=O)c5ccccc5)ccc4sc3c2=O)CC1 Show InChI InChI=1S/C30H29N5O4S/c1-39-24-10-6-5-9-23(24)34-16-13-33(14-17-34)15-18-35-29(37)27-26(32-30(35)38)22-19-21(11-12-25(22)40-27)31-28(36)20-7-3-2-4-8-20/h2-12,19H,13-18H2,1H3,(H,31,36)(H,32,38) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 1.10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Catania
Curated by ChEMBL
| Assay Description
Displacement of [125I]BE2254 from human alpha1a receptor expressed in HEK293 cells |
Eur J Med Chem 83: 419-32 (2014)
Article DOI: 10.1016/j.ejmech.2014.06.057
BindingDB Entry DOI: 10.7270/Q2639RBH |
More data for this
Ligand-Target Pair | |
Alpha-1D adrenergic receptor
(Homo sapiens (Human)) | BDBM50023186
(CHEMBL3298748)Show SMILES COc1ccccc1N1CCN(CCn2c(=O)[nH]c3c4cc(NC(=O)CCCCc5ccccc5)ccc4sc3c2=O)CC1 Show InChI InChI=1S/C34H37N5O4S/c1-43-28-13-7-6-12-27(28)38-20-17-37(18-21-38)19-22-39-33(41)32-31(36-34(39)42)26-23-25(15-16-29(26)44-32)35-30(40)14-8-5-11-24-9-3-2-4-10-24/h2-4,6-7,9-10,12-13,15-16,23H,5,8,11,14,17-22H2,1H3,(H,35,40)(H,36,42) | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 1.20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Catania
Curated by ChEMBL
| Assay Description
Displacement of [125I]BE2254 from human alpha1d receptor expressed in HEK293 cells |
Eur J Med Chem 83: 419-32 (2014)
Article DOI: 10.1016/j.ejmech.2014.06.057
BindingDB Entry DOI: 10.7270/Q2639RBH |
More data for this
Ligand-Target Pair | |
Alpha-1A adrenergic receptor
(Homo sapiens (Human)) | BDBM50476083
(CHEMBL220515)Show SMILES COc1ccc(Cl)cc1N1CCN(CCn2c(C)nc3c4ccccc4[nH]c3c2=O)CC1 Show InChI InChI=1S/C24H26ClN5O2/c1-16-26-22-18-5-3-4-6-19(18)27-23(22)24(31)30(16)14-11-28-9-12-29(13-10-28)20-15-17(25)7-8-21(20)32-2/h3-8,15,27H,9-14H2,1-2H3 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 1.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Catania
Curated by ChEMBL
| Assay Description
Displacement of [125I]BE2254 from human cloned adrenergic alpha 1A receptor expressed in HEK293 cells |
Bioorg Med Chem Lett 16: 6200-3 (2006)
Article DOI: 10.1016/j.bmcl.2006.09.034
BindingDB Entry DOI: 10.7270/Q2GT5QZC |
More data for this
Ligand-Target Pair | |
Alpha-1D adrenergic receptor
(Homo sapiens (Human)) | BDBM50023199
(CHEMBL220781)Show SMILES COc1ccccc1N1CCN(CCn2c(=O)[nH]c3c4ccccc4sc3c2=O)CC1 Show InChI InChI=1S/C23H24N4O3S/c1-30-18-8-4-3-7-17(18)26-13-10-25(11-14-26)12-15-27-22(28)21-20(24-23(27)29)16-6-2-5-9-19(16)31-21/h2-9H,10-15H2,1H3,(H,24,29) | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 1.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Catania
Curated by ChEMBL
| Assay Description
Displacement of [125I]BE2254 from human alpha1d receptor expressed in HEK293 cells |
Eur J Med Chem 83: 419-32 (2014)
Article DOI: 10.1016/j.ejmech.2014.06.057
BindingDB Entry DOI: 10.7270/Q2639RBH |
More data for this
Ligand-Target Pair | |
Alpha-1D adrenergic receptor
(Homo sapiens (Human)) | BDBM50023199
(CHEMBL220781)Show SMILES COc1ccccc1N1CCN(CCn2c(=O)[nH]c3c4ccccc4sc3c2=O)CC1 Show InChI InChI=1S/C23H24N4O3S/c1-30-18-8-4-3-7-17(18)26-13-10-25(11-14-26)12-15-27-22(28)21-20(24-23(27)29)16-6-2-5-9-19(16)31-21/h2-9H,10-15H2,1H3,(H,24,29) | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 1.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Catania
Curated by ChEMBL
| Assay Description
Displacement of [125I]BE2254 from human cloned adrenergic alpha 1D receptor expressed in HEK293 cells |
Bioorg Med Chem Lett 16: 6200-3 (2006)
Article DOI: 10.1016/j.bmcl.2006.09.034
BindingDB Entry DOI: 10.7270/Q2GT5QZC |
More data for this
Ligand-Target Pair | |
Alpha-1A adrenergic receptor
(Homo sapiens (Human)) | BDBM50100565
(6-{2-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-ethyl}-...)Show SMILES COc1ccccc1N1CCN(CCn2nc(-c3ccccc3)c3c(C)onc3c2=O)CC1 Show InChI InChI=1S/C25H27N5O3/c1-18-22-23(19-8-4-3-5-9-19)26-30(25(31)24(22)27-33-18)17-14-28-12-15-29(16-13-28)20-10-6-7-11-21(20)32-2/h3-11H,12-17H2,1-2H3 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 1.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Catania
Curated by ChEMBL
| Assay Description
In vitro binding affinity at human Alpha-1A adrenergic receptor. |
J Med Chem 46: 2877-94 (2003)
Article DOI: 10.1021/jm0307741
BindingDB Entry DOI: 10.7270/Q2G73FFQ |
More data for this
Ligand-Target Pair | |
Alpha-1D adrenergic receptor
(Homo sapiens (Human)) | BDBM50100565
(6-{2-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-ethyl}-...)Show SMILES COc1ccccc1N1CCN(CCn2nc(-c3ccccc3)c3c(C)onc3c2=O)CC1 Show InChI InChI=1S/C25H27N5O3/c1-18-22-23(19-8-4-3-5-9-19)26-30(25(31)24(22)27-33-18)17-14-28-12-15-29(16-13-28)20-10-6-7-11-21(20)32-2/h3-11H,12-17H2,1-2H3 | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 1.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Catania
Curated by ChEMBL
| Assay Description
In vitro binding affinity at human Alpha-1D adrenergic receptor. |
J Med Chem 46: 2877-94 (2003)
Article DOI: 10.1021/jm0307741
BindingDB Entry DOI: 10.7270/Q2G73FFQ |
More data for this
Ligand-Target Pair | |
Alpha-1A adrenergic receptor
(Homo sapiens (Human)) | BDBM50023184
(CHEMBL3298746)Show SMILES COc1ccccc1N1CCN(CCn2c(=O)[nH]c3c4cc(NC(=O)Cc5ccccc5)ccc4sc3c2=O)CC1 Show InChI InChI=1S/C31H31N5O4S/c1-40-25-10-6-5-9-24(25)35-16-13-34(14-17-35)15-18-36-30(38)29-28(33-31(36)39)23-20-22(11-12-26(23)41-29)32-27(37)19-21-7-3-2-4-8-21/h2-12,20H,13-19H2,1H3,(H,32,37)(H,33,39) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 1.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Catania
Curated by ChEMBL
| Assay Description
Displacement of [125I]BE2254 from human alpha1a receptor expressed in HEK293 cells |
Eur J Med Chem 83: 419-32 (2014)
Article DOI: 10.1016/j.ejmech.2014.06.057
BindingDB Entry DOI: 10.7270/Q2639RBH |
More data for this
Ligand-Target Pair | |
Alpha-1D adrenergic receptor
(Homo sapiens (Human)) | BDBM50476086
(CHEMBL386005)Show SMILES COc1ccc(Cl)cc1N1CCN(CCn2c(=O)[nH]c3c4ccccc4[nH]c3c2=O)CC1 Show InChI InChI=1S/C23H24ClN5O3/c1-32-19-7-6-15(24)14-18(19)28-11-8-27(9-12-28)10-13-29-22(30)21-20(26-23(29)31)16-4-2-3-5-17(16)25-21/h2-7,14,25H,8-13H2,1H3,(H,26,31) | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 1.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Catania
Curated by ChEMBL
| Assay Description
Displacement of [125I]BE2254 from human cloned adrenergic alpha 1D receptor expressed in HEK293 cells |
Bioorg Med Chem Lett 16: 6200-3 (2006)
Article DOI: 10.1016/j.bmcl.2006.09.034
BindingDB Entry DOI: 10.7270/Q2GT5QZC |
More data for this
Ligand-Target Pair | |
Alpha-1A adrenergic receptor
(Homo sapiens (Human)) | BDBM50023200
(CHEMBL220221)Show SMILES COc1ccccc1N1CCN(CCn2c(C)nc3c4ccccc4sc3c2=O)CC1 Show InChI InChI=1S/C24H26N4O2S/c1-17-25-22-18-7-3-6-10-21(18)31-23(22)24(29)28(17)16-13-26-11-14-27(15-12-26)19-8-4-5-9-20(19)30-2/h3-10H,11-16H2,1-2H3 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
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GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 1.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Catania
Curated by ChEMBL
| Assay Description
Displacement of [125I]BE2254 from human alpha1a receptor expressed in HEK293 cells |
Eur J Med Chem 83: 419-32 (2014)
Article DOI: 10.1016/j.ejmech.2014.06.057
BindingDB Entry DOI: 10.7270/Q2639RBH |
More data for this
Ligand-Target Pair | |
Alpha-1A adrenergic receptor
(Homo sapiens (Human)) | BDBM50023200
(CHEMBL220221)Show SMILES COc1ccccc1N1CCN(CCn2c(C)nc3c4ccccc4sc3c2=O)CC1 Show InChI InChI=1S/C24H26N4O2S/c1-17-25-22-18-7-3-6-10-21(18)31-23(22)24(29)28(17)16-13-26-11-14-27(15-12-26)19-8-4-5-9-20(19)30-2/h3-10H,11-16H2,1-2H3 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 1.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Catania
Curated by ChEMBL
| Assay Description
Displacement of [125I]BE2254 from human cloned adrenergic alpha 1A receptor expressed in HEK293 cells |
Bioorg Med Chem Lett 16: 6200-3 (2006)
Article DOI: 10.1016/j.bmcl.2006.09.034
BindingDB Entry DOI: 10.7270/Q2GT5QZC |
More data for this
Ligand-Target Pair | |
Alpha-1D adrenergic receptor
(Homo sapiens (Human)) | BDBM50122803
((SNAP-8719)[4-(4-Amino-6,7-dimethoxy-quinazolin-2-...)Show SMILES C[C@H](CN1CCN(CC1)c1cc(F)c(F)cc1F)N1C(=O)CC2(CCCC2)CC1=O Show InChI InChI=1S/C22H28F3N3O2/c1-15(28-20(29)12-22(13-21(28)30)4-2-3-5-22)14-26-6-8-27(9-7-26)19-11-17(24)16(23)10-18(19)25/h10-11,15H,2-9,12-14H2,1H3/t15-/m1/s1 | Reactome pathway
KEGG
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CHEMBL
PC cid
PC sid
UniChem
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| Article
PubMed
| 1.60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Catania
Curated by ChEMBL
| Assay Description
In vitro binding affinity at human Alpha-1D adrenergic receptor. |
J Med Chem 46: 2877-94 (2003)
Article DOI: 10.1021/jm0307741
BindingDB Entry DOI: 10.7270/Q2G73FFQ |
More data for this
Ligand-Target Pair | |
Alpha-1A adrenergic receptor
(Homo sapiens (Human)) | BDBM50023190
(CHEMBL3298017)Show SMILES COc1ccccc1N1CCN(CCn2c(=O)[nH]c3c4cc(NC(=O)CCCC(=O)NCCc5ccccc5)ccc4sc3c2=O)CC1 Show InChI InChI=1S/C36H40N6O5S/c1-47-29-11-6-5-10-28(29)41-21-18-40(19-22-41)20-23-42-35(45)34-33(39-36(42)46)27-24-26(14-15-30(27)48-34)38-32(44)13-7-12-31(43)37-17-16-25-8-3-2-4-9-25/h2-6,8-11,14-15,24H,7,12-13,16-23H2,1H3,(H,37,43)(H,38,44)(H,39,46) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 1.60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Catania
Curated by ChEMBL
| Assay Description
Displacement of [125I]BE2254 from human alpha1a receptor expressed in HEK293 cells |
Eur J Med Chem 83: 419-32 (2014)
Article DOI: 10.1016/j.ejmech.2014.06.057
BindingDB Entry DOI: 10.7270/Q2639RBH |
More data for this
Ligand-Target Pair | |
Alpha-1D adrenergic receptor
(Homo sapiens (Human)) | BDBM50030614
(5-Chloro-8-methyl-1-vinyl-6,7,8,9-tetrahydro-2-thi...)Show InChI InChI=1S/C14H14ClNS/c1-3-12-10-8-16(2)7-6-9-11(15)4-5-13(17-12)14(9)10/h3-5H,1,6-8H2,2H3 | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 1.60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Catania
Curated by ChEMBL
| Assay Description
In vitro binding affinity at human Alpha-1D adrenergic receptor. |
J Med Chem 46: 2877-94 (2003)
Article DOI: 10.1021/jm0307741
BindingDB Entry DOI: 10.7270/Q2G73FFQ |
More data for this
Ligand-Target Pair | |
Alpha-1A adrenergic receptor
(Homo sapiens (Human)) | BDBM50023192
(CHEMBL3298019)Show SMILES COc1ccccc1N1CCN(CCn2c(=O)[nH]c3c4cc(NC(=O)CCCN(C)C)ccc4sc3c2=O)CC1 Show InChI InChI=1S/C29H36N6O4S/c1-32(2)12-6-9-25(36)30-20-10-11-24-21(19-20)26-27(40-24)28(37)35(29(38)31-26)18-15-33-13-16-34(17-14-33)22-7-4-5-8-23(22)39-3/h4-5,7-8,10-11,19H,6,9,12-18H2,1-3H3,(H,30,36)(H,31,38) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
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AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 1.70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Catania
Curated by ChEMBL
| Assay Description
Displacement of [125I]BE2254 from human alpha1a receptor expressed in HEK293 cells |
Eur J Med Chem 83: 419-32 (2014)
Article DOI: 10.1016/j.ejmech.2014.06.057
BindingDB Entry DOI: 10.7270/Q2639RBH |
More data for this
Ligand-Target Pair | |
Alpha-1D adrenergic receptor
(Homo sapiens (Human)) | BDBM50023192
(CHEMBL3298019)Show SMILES COc1ccccc1N1CCN(CCn2c(=O)[nH]c3c4cc(NC(=O)CCCN(C)C)ccc4sc3c2=O)CC1 Show InChI InChI=1S/C29H36N6O4S/c1-32(2)12-6-9-25(36)30-20-10-11-24-21(19-20)26-27(40-24)28(37)35(29(38)31-26)18-15-33-13-16-34(17-14-33)22-7-4-5-8-23(22)39-3/h4-5,7-8,10-11,19H,6,9,12-18H2,1-3H3,(H,30,36)(H,31,38) | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 1.70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Catania
Curated by ChEMBL
| Assay Description
Displacement of [125I]BE2254 from human alpha1d receptor expressed in HEK293 cells |
Eur J Med Chem 83: 419-32 (2014)
Article DOI: 10.1016/j.ejmech.2014.06.057
BindingDB Entry DOI: 10.7270/Q2639RBH |
More data for this
Ligand-Target Pair | |
Alpha-1B adrenergic receptor
(Homo sapiens (Human)) | BDBM50023192
(CHEMBL3298019)Show SMILES COc1ccccc1N1CCN(CCn2c(=O)[nH]c3c4cc(NC(=O)CCCN(C)C)ccc4sc3c2=O)CC1 Show InChI InChI=1S/C29H36N6O4S/c1-32(2)12-6-9-25(36)30-20-10-11-24-21(19-20)26-27(40-24)28(37)35(29(38)31-26)18-15-33-13-16-34(17-14-33)22-7-4-5-8-23(22)39-3/h4-5,7-8,10-11,19H,6,9,12-18H2,1-3H3,(H,30,36)(H,31,38) | UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 1.70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Catania
Curated by ChEMBL
| Assay Description
Displacement of [125I]BE2254 from human alpha1b receptor expressed in HEK293 cells |
Eur J Med Chem 83: 419-32 (2014)
Article DOI: 10.1016/j.ejmech.2014.06.057
BindingDB Entry DOI: 10.7270/Q2639RBH |
More data for this
Ligand-Target Pair | |
Alpha-1B adrenergic receptor
(Homo sapiens (Human)) | BDBM50006952
(2-{2-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-ethyl}-...)Show SMILES COc1ccccc1N1CCN(CCn2c(=O)[nH]c3c4ccccc4[nH]c3c2=O)CC1 Show InChI InChI=1S/C23H25N5O3/c1-31-19-9-5-4-8-18(19)27-13-10-26(11-14-27)12-15-28-22(29)21-20(25-23(28)30)16-6-2-3-7-17(16)24-21/h2-9,24H,10-15H2,1H3,(H,25,30) | UniProtKB/SwissProt
antibodypedia
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| Purchase
CHEMBL
PC cid
PC sid
UniChem
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| Article
PubMed
| 1.80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Catania
Curated by ChEMBL
| Assay Description
Displacement of [125I]BE2254 from human cloned adrenergic alpha 1B receptor expressed in HEK293 cells |
Bioorg Med Chem Lett 16: 6200-3 (2006)
Article DOI: 10.1016/j.bmcl.2006.09.034
BindingDB Entry DOI: 10.7270/Q2GT5QZC |
More data for this
Ligand-Target Pair | |
Alpha-1B adrenergic receptor
(Homo sapiens (Human)) | BDBM50006952
(2-{2-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-ethyl}-...)Show SMILES COc1ccccc1N1CCN(CCn2c(=O)[nH]c3c4ccccc4[nH]c3c2=O)CC1 Show InChI InChI=1S/C23H25N5O3/c1-31-19-9-5-4-8-18(19)27-13-10-26(11-14-27)12-15-28-22(29)21-20(25-23(28)30)16-6-2-3-7-17(16)24-21/h2-9,24H,10-15H2,1H3,(H,25,30) | UniProtKB/SwissProt
antibodypedia
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CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 1.82 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Catania
Curated by ChEMBL
| Assay Description
Binding affinity to adrenergic Alpha-1B receptor |
Eur J Med Chem 46: 2676-90 (2011)
Article DOI: 10.1016/j.ejmech.2011.03.054
BindingDB Entry DOI: 10.7270/Q25140G9 |
More data for this
Ligand-Target Pair | |
Alpha-1A adrenergic receptor
(Homo sapiens (Human)) | BDBM50418752
(CHEMBL1796033)Show SMILES COc1ccccc1N1CCN(CCCCN2C(=O)CC(CC2=O)c2ccccc2)CC1 Show InChI InChI=1S/C26H33N3O3/c1-32-24-12-6-5-11-23(24)28-17-15-27(16-18-28)13-7-8-14-29-25(30)19-22(20-26(29)31)21-9-3-2-4-10-21/h2-6,9-12,22H,7-8,13-20H2,1H3 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 1.82 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Catania
Curated by ChEMBL
| Assay Description
Displacement of [125I]BE-2254 from human adrenergic alpha1A receptor expressed in HEK293 cells |
Eur J Med Chem 46: 2676-90 (2011)
Article DOI: 10.1016/j.ejmech.2011.03.054
BindingDB Entry DOI: 10.7270/Q25140G9 |
More data for this
Ligand-Target Pair | |
Alpha-1B adrenergic receptor
(Homo sapiens (Human)) | BDBM50006952
(2-{2-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-ethyl}-...)Show SMILES COc1ccccc1N1CCN(CCn2c(=O)[nH]c3c4ccccc4[nH]c3c2=O)CC1 Show InChI InChI=1S/C23H25N5O3/c1-31-19-9-5-4-8-18(19)27-13-10-26(11-14-27)12-15-28-22(29)21-20(25-23(28)30)16-6-2-3-7-17(16)24-21/h2-9,24H,10-15H2,1H3,(H,25,30) | UniProtKB/SwissProt
antibodypedia
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PC cid
PC sid
UniChem
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PubMed
| 1.82 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Catania
Curated by ChEMBL
| Assay Description
Displacement of [125I]BE-2254 from human adrenergic Alpha-1B receptor expressed in HEK293 cells |
Eur J Med Chem 46: 2676-90 (2011)
Article DOI: 10.1016/j.ejmech.2011.03.054
BindingDB Entry DOI: 10.7270/Q25140G9 |
More data for this
Ligand-Target Pair | |
Alpha-1B adrenergic receptor
(Homo sapiens (Human)) | BDBM50023189
(CHEMBL3297829)Show SMILES COc1ccccc1N1CCN(CCn2c(=O)[nH]c3c4cc(NC(=O)CCCC(=O)N(C)Cc5ccccc5)ccc4sc3c2=O)CC1 Show InChI InChI=1S/C36H40N6O5S/c1-39(24-25-9-4-3-5-10-25)32(44)14-8-13-31(43)37-26-15-16-30-27(23-26)33-34(48-30)35(45)42(36(46)38-33)22-19-40-17-20-41(21-18-40)28-11-6-7-12-29(28)47-2/h3-7,9-12,15-16,23H,8,13-14,17-22,24H2,1-2H3,(H,37,43)(H,38,46) | UniProtKB/SwissProt
antibodypedia
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AffyNet
| CHEMBL
PC cid
PC sid
UniChem
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| Article
PubMed
| 1.90 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Catania
Curated by ChEMBL
| Assay Description
Displacement of [125I]BE2254 from human alpha1b receptor expressed in HEK293 cells |
Eur J Med Chem 83: 419-32 (2014)
Article DOI: 10.1016/j.ejmech.2014.06.057
BindingDB Entry DOI: 10.7270/Q2639RBH |
More data for this
Ligand-Target Pair | |
Alpha-1D adrenergic receptor
(Homo sapiens (Human)) | BDBM50418752
(CHEMBL1796033)Show SMILES COc1ccccc1N1CCN(CCCCN2C(=O)CC(CC2=O)c2ccccc2)CC1 Show InChI InChI=1S/C26H33N3O3/c1-32-24-12-6-5-11-23(24)28-17-15-27(16-18-28)13-7-8-14-29-25(30)19-22(20-26(29)31)21-9-3-2-4-10-21/h2-6,9-12,22H,7-8,13-20H2,1H3 | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 2 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Catania
Curated by ChEMBL
| Assay Description
Antagonist activity against human cloned adrenergic Alpha-1D receptor expressed in HEK293 cells assessed as inhibition of norepinephrine-induced [3H]... |
Eur J Med Chem 46: 2676-90 (2011)
Article DOI: 10.1016/j.ejmech.2011.03.054
BindingDB Entry DOI: 10.7270/Q25140G9 |
More data for this
Ligand-Target Pair | |
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