Compile Data Set for Download or QSAR

Found 575 hits with Last Name = 'mceachern' and Initial = 'ej'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Protein O-GlcNAcase (Homo sapiens (Human))	BDBM139926 (US8901087, 2) Show SMILES CCCNC1=N[C@H]2[C@H](O[C@H]([C@H](C)O)[C@@H](O)[C@@H]2O)S1 |t:4| Show InChI InChI=1S/C11H20N2O4S/c1-3-4-12-11-13-6-7(15)8(16)9(5(2)14)17-10(6)18-11/h5-10,14-16H,3-4H2,1-2H3,(H,12,13)/t5-,6+,7+,8-,9+,10+/m0/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	0.0500	-58.8	n/a	n/a	n/a	n/a	n/a	7.0	25
Merck Sharp & Dohme Corp. US Patent					Assay Description Enzymatic reactions are carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acety...				US Patent US8901087 (2014) BindingDB Entry DOI: 10.7270/Q24B301W
					More data for this Ligand-Target Pair
Protein O-GlcNAcase (Homo sapiens (Human))	BDBM481715 (US10913733, Example 26) Show SMILES [#6]-[#6](=O)-[#7]-c1ncc(-[#6]-[#7]-2-[#6]-[#6]\[#6](-[#6]-[#6]-2)=[#6]\c2ccc(-[#6]F)cc2)s1 Show InChI InChI=1S/C19H22FN3OS/c1-14(24)22-19-21-12-18(25-19)13-23-8-6-16(7-9-23)10-15-2-4-17(11-20)5-3-15/h2-5,10,12H,6-9,11,13H2,1H3,(H,21,22,24)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.0750	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Alectos Therapeutics Inc.; Merck Sharp & Dohme Corp. US Patent					Assay Description Experimental procedure for kinetic analyses: Enzymatic reactions were carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (p...				US Patent US10913733 (2021) BindingDB Entry DOI: 10.7270/Q29G5QXX
					More data for this Ligand-Target Pair
Protein O-GlcNAcase (Homo sapiens (Human))	BDBM481707 (N-(5-((4-(4-(N,N- dimethylsulfamoyl) benzylidene)p...) Show SMILES [#6]-[#7](-[#6])S(=O)(=O)c1ccc(\[#6]=[#6]-2\[#6]-[#6]-[#7](-[#6]-c3cnc(-[#7]-[#6](-[#6])=O)s3)-[#6]-[#6]-2)cc1 Show InChI InChI=1S/C20H26N4O3S2/c1-15(25)22-20-21-13-18(28-20)14-24-10-8-17(9-11-24)12-16-4-6-19(7-5-16)29(26,27)23(2)3/h4-7,12-13H,8-11,14H2,1-3H3,(H,21,22,25)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.0950	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Alectos Therapeutics Inc.; Merck Sharp & Dohme Corp. US Patent					Assay Description Experimental procedure for kinetic analyses: Enzymatic reactions were carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (p...				US Patent US10913733 (2021) BindingDB Entry DOI: 10.7270/Q29G5QXX
					More data for this Ligand-Target Pair
Protein O-GlcNAcase (Homo sapiens (Human))	BDBM77064 (US9695197, 4) Show SMILES CNC1=N[C@H]2[C@@H](S1)S[C@H](CO)[C@@H](O)[C@@H]2O |r,t:2| Show InChI InChI=1S/C8H14N2O3S2/c1-9-8-10-4-6(13)5(12)3(2-11)14-7(4)15-8/h3-7,11-13H,2H2,1H3,(H,9,10)/t3-,4-,5-,6-,7-/m1/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.110	-56.8	n/a	n/a	n/a	n/a	n/a	7.0	25
Alectos Therapeutics Inc.; Merck Sharp & Dohme Corp. US Patent					Assay Description Enzymatic reactions were carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acet...				US Patent US9695197 (2017) BindingDB Entry DOI: 10.7270/Q247481J
					More data for this Ligand-Target Pair
Protein O-GlcNAcase (Homo sapiens (Human))	BDBM481720 (US10913733, Example 31) Show SMILES [#6]-[#7](-[#6])-[#6](=O)-c1ccc(\[#6]=[#6]-2\[#6]-[#6]-[#7](-[#6]-c3cnc(-[#7]-[#6](-[#6])=O)s3)-[#6]-[#6]-2)cc1 Show InChI InChI=1S/C21H26N4O2S/c1-15(26)23-21-22-13-19(28-21)14-25-10-8-17(9-11-25)12-16-4-6-18(7-5-16)20(27)24(2)3/h4-7,12-13H,8-11,14H2,1-3H3,(H,22,23,26)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.117	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Alectos Therapeutics Inc.; Merck Sharp & Dohme Corp. US Patent					Assay Description Experimental procedure for kinetic analyses: Enzymatic reactions were carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (p...				US Patent US10913733 (2021) BindingDB Entry DOI: 10.7270/Q29G5QXX
					More data for this Ligand-Target Pair
Protein O-GlcNAcase (Homo sapiens (Human))	BDBM139933 (US8901087, 27) Show SMILES CCNC1=N[C@H]2[C@H](O[C@H]([C@H](C)O)[C@@H](O)[C@@H]2O)S1 |t:3| Show InChI InChI=1S/C10H18N2O4S/c1-3-11-10-12-5-6(14)7(15)8(4(2)13)16-9(5)17-10/h4-9,13-15H,3H2,1-2H3,(H,11,12)/t4-,5+,6+,7-,8+,9+/m0/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	0.120	-56.6	n/a	n/a	n/a	n/a	n/a	7.0	25
Merck Sharp & Dohme Corp. US Patent					Assay Description Enzymatic reactions are carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acety...				US Patent US8901087 (2014) BindingDB Entry DOI: 10.7270/Q24B301W
					More data for this Ligand-Target Pair
Protein O-GlcNAcase (Homo sapiens (Human))	BDBM177755 (US9120781, 18) Show SMILES OC[C@H]1C[C@@H]2OC(=N[C@@H]2[C@@H](O)[C@@H]1O)N1CCC1 |r,c:6| Show InChI InChI=1S/C11H18N2O4/c14-5-6-4-7-8(10(16)9(6)15)12-11(17-7)13-2-1-3-13/h6-10,14-16H,1-5H2/t6-,7+,8+,9-,10-/m1/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	0.130	-56.4	n/a	n/a	n/a	n/a	n/a	7.0	25
Simon Fraser University; Merck Sharp & Dohme Corp.; Alectos Therapeutics Inc. US Patent					Assay Description Enzymatic reactions are carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acety...				US Patent US9120781 (2015) BindingDB Entry DOI: 10.7270/Q2DZ072S
					More data for this Ligand-Target Pair
Protein O-GlcNAcase (Homo sapiens (Human))	BDBM139959 (US8901087, 191) Show SMILES CNC1=N[C@H]2[C@H](O[C@H]([C@@H](O)C(F)F)[C@@H](O)[C@@H]2O)S1 |t:2| Show InChI InChI=1S/C9H14F2N2O4S/c1-12-9-13-2-3(14)4(15)6(5(16)7(10)11)17-8(2)18-9/h2-8,14-16H,1H3,(H,12,13)/t2-,3-,4+,5-,6+,8-/m1/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	0.140	-56.2	n/a	n/a	n/a	n/a	n/a	7.0	25
Merck Sharp & Dohme Corp. US Patent					Assay Description Enzymatic reactions are carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acety...				US Patent US8901087 (2014) BindingDB Entry DOI: 10.7270/Q24B301W
					More data for this Ligand-Target Pair
Protein O-GlcNAcase (Homo sapiens (Human))	BDBM179374 (US9126957, 10) Show SMILES C[C@@H](O)[C@@H]1C[C@H]2SC(=N[C@H]2[C@H](O)[C@H]1O)N(C)C |c:7| Show InChI InChI=1S/C11H20N2O3S/c1-5(14)6-4-7-8(10(16)9(6)15)12-11(17-7)13(2)3/h5-10,14-16H,4H2,1-3H3/t5-,6+,7-,8-,9+,10+/m1/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	0.140	-56.2	n/a	n/a	n/a	n/a	n/a	7.0	25
MERCK SHARP & DOHME CORP.; ALECTOS THERAPEUTICS, INC. US Patent					Assay Description Enzymatic reactions are carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acety...				US Patent US9126957 (2015) BindingDB Entry DOI: 10.7270/Q2DV1HN2
					More data for this Ligand-Target Pair
Protein O-GlcNAcase (Homo sapiens (Human))	BDBM314813 ((3aR,5S,6S,7R,7aR)-5-((R)-1-(4- benzylbenzyloxy)-2...) Show SMILES CNC1=N[C@H]2[C@H](O[C@H]([C@@H](OCc3ccc(Cc4ccccc4)cc3)C(F)(F)F)[C@@H](O)[C@@H]2O)S1 |t:2| Show InChI InChI=1S/C23H25F3N2O4S/c1-27-22-28-16-17(29)18(30)19(32-21(16)33-22)20(23(24,25)26)31-12-15-9-7-14(8-10-15)11-13-5-3-2-4-6-13/h2-10,16-21,29-30H,11-12H2,1H3,(H,27,28)/t16-,17-,18+,19+,20-,21-/m1/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.160	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
ALECTOS THERAPEUTICS, INC.; MERCK SHARP & DOHME CORP. US Patent					Assay Description Enzymatic reactions were carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acet...				US Patent US9611275 (2017) BindingDB Entry DOI: 10.7270/Q2833V4D
					More data for this Ligand-Target Pair
Protein O-GlcNAcase (Homo sapiens (Human))	BDBM139951 (US8901087, 95) Show SMILES CNC1=N[C@H]2[C@H](O[C@H]([C@@H](O)C(F)(F)F)[C@@H](O)[C@@H]2O)S1 |t:2| Show InChI InChI=1S/C9H13F3N2O4S/c1-13-8-14-2-3(15)4(16)5(18-7(2)19-8)6(17)9(10,11)12/h2-7,15-17H,1H3,(H,13,14)/t2-,3-,4+,5+,6-,7-/m1/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	0.160	-55.9	n/a	n/a	n/a	n/a	n/a	7.0	25
Merck Sharp & Dohme Corp. US Patent					Assay Description Enzymatic reactions are carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acety...				US Patent US8901087 (2014) BindingDB Entry DOI: 10.7270/Q24B301W
					More data for this Ligand-Target Pair
Protein O-GlcNAcase (Homo sapiens (Human))	BDBM481715 (US10913733, Example 26) Show SMILES [#6]-[#6](=O)-[#7]-c1ncc(-[#6]-[#7]-2-[#6]-[#6]\[#6](-[#6]-[#6]-2)=[#6]\c2ccc(-[#6]F)cc2)s1 Show InChI InChI=1S/C19H22FN3OS/c1-14(24)22-19-21-12-18(25-19)13-23-8-6-16(7-9-23)10-15-2-4-17(11-20)5-3-15/h2-5,10,12H,6-9,11,13H2,1H3,(H,21,22,24)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.167	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Alectos Therapeutics Inc.; Merck Sharp & Dohme Corp. US Patent					Assay Description Experimental procedure for kinetic analyses: Enzymatic reactions were carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (p...				US Patent US10913733 (2021) BindingDB Entry DOI: 10.7270/Q29G5QXX
					More data for this Ligand-Target Pair
Protein O-GlcNAcase (Homo sapiens (Human))	BDBM139925 (US8901087, 1) Show SMILES C[C@H](O)[C@H]1O[C@@H]2SC(=N[C@@H]2[C@@H](O)[C@@H]1O)N(C)C |c:7| Show InChI InChI=1S/C10H18N2O4S/c1-4(13)8-7(15)6(14)5-9(16-8)17-10(11-5)12(2)3/h4-9,13-15H,1-3H3/t4-,5+,6+,7-,8+,9+/m0/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	0.170	-55.8	n/a	n/a	n/a	n/a	n/a	7.0	25
Merck Sharp & Dohme Corp. US Patent					Assay Description Enzymatic reactions are carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acety...				US Patent US8901087 (2014) BindingDB Entry DOI: 10.7270/Q24B301W
					More data for this Ligand-Target Pair
Protein O-GlcNAcase (Homo sapiens (Human))	BDBM139952 (US8901087, 97) Show SMILES CCCNC1=N[C@H]2[C@H](O[C@H]([C@@H](O)C(F)(F)F)[C@@H](O)[C@@H]2O)S1 |t:4| Show InChI InChI=1S/C11H17F3N2O4S/c1-2-3-15-10-16-4-5(17)6(18)7(20-9(4)21-10)8(19)11(12,13)14/h4-9,17-19H,2-3H2,1H3,(H,15,16)/t4-,5-,6+,7+,8-,9-/m1/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	0.170	-55.8	n/a	n/a	n/a	n/a	n/a	7.0	25
Merck Sharp & Dohme Corp. US Patent					Assay Description Enzymatic reactions are carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acety...				US Patent US8901087 (2014) BindingDB Entry DOI: 10.7270/Q24B301W
					More data for this Ligand-Target Pair
Protein O-GlcNAcase (Homo sapiens (Human))	BDBM139946 (US8901087, 76) Show SMILES C[C@H](O)[C@H]1O[C@@H]2SC(=N[C@@H]2[C@@H](O)[C@@H]1O)N1CCC1 |c:7| Show InChI InChI=1S/C11H18N2O4S/c1-5(14)9-8(16)7(15)6-10(17-9)18-11(12-6)13-3-2-4-13/h5-10,14-16H,2-4H2,1H3/t5-,6+,7+,8-,9+,10+/m0/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	0.180	-55.6	n/a	n/a	n/a	n/a	n/a	7.0	25
Merck Sharp & Dohme Corp. US Patent					Assay Description Enzymatic reactions are carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acety...				US Patent US8901087 (2014) BindingDB Entry DOI: 10.7270/Q24B301W
					More data for this Ligand-Target Pair
Protein O-GlcNAcase (Homo sapiens (Human))	BDBM46008 (US8901087, 96) Show SMILES CN(C)C1=N[C@H]2[C@H](O[C@H](C(O)C3SCCCS3)[C@@H](COCc3ccccc3)[C@@H]2OCc2ccccc2)S1 |t:3| Show InChI InChI=1S/C28H36N2O4S3/c1-30(2)28-29-22-24(33-17-20-12-7-4-8-13-20)21(18-32-16-19-10-5-3-6-11-19)25(34-26(22)37-28)23(31)27-35-14-9-15-36-27/h3-8,10-13,21-27,31H,9,14-18H2,1-2H3/t21-,22+,23?,24-,25-,26+/m0/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	0.190	-55.5	n/a	n/a	n/a	n/a	n/a	7.0	25
Merck Sharp & Dohme Corp. US Patent					Assay Description Enzymatic reactions are carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acety...				US Patent US8901087 (2014) BindingDB Entry DOI: 10.7270/Q24B301W
					More data for this Ligand-Target Pair
Protein O-GlcNAcase (Homo sapiens (Human))	BDBM314809 ((3aR,5S,6S,7R,7aR)-2-(dimethylamino)-5-((R)-1-meth...) Show SMILES CO[C@H](C)[C@H]1O[C@@H]2SC(=N[C@@H]2[C@@H](O)[C@@H]1O)N(C)C |c:8| Show InChI InChI=1S/C11H20N2O4S/c1-5(16-4)9-8(15)7(14)6-10(17-9)18-11(12-6)13(2)3/h5-10,14-15H,1-4H3/t5-,6-,7-,8+,9-,10-/m1/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.190	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
ALECTOS THERAPEUTICS, INC.; MERCK SHARP & DOHME CORP. US Patent					Assay Description Enzymatic reactions were carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acet...				US Patent US9611275 (2017) BindingDB Entry DOI: 10.7270/Q2833V4D
					More data for this Ligand-Target Pair
Protein O-GlcNAcase (Homo sapiens (Human))	BDBM177758 (US9120781, 26) Show SMILES CNC1=N[C@H]2[C@H](C[C@H](CO)[C@@H](O)[C@@H]2O)S1 |r,t:2| Show InChI InChI=1S/C9H16N2O3S/c1-10-9-11-6-5(15-9)2-4(3-12)7(13)8(6)14/h4-8,12-14H,2-3H2,1H3,(H,10,11)/t4-,5+,6+,7-,8-/m1/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	0.200	-55.4	n/a	n/a	n/a	n/a	n/a	7.0	25
Simon Fraser University; Merck Sharp & Dohme Corp.; Alectos Therapeutics Inc. US Patent					Assay Description Enzymatic reactions are carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acety...				US Patent US9120781 (2015) BindingDB Entry DOI: 10.7270/Q2DZ072S
					More data for this Ligand-Target Pair
Protein O-GlcNAcase (Homo sapiens (Human))	BDBM139941 (US8901087, 63) Show SMILES CN(C)C1=N[C@H]2[C@H](O[C@H]([C@@H](O)C=C)[C@@H](O)[C@@H]2O)S1 |t:3| Show InChI InChI=1S/C11H18N2O4S/c1-4-5(14)9-8(16)7(15)6-10(17-9)18-11(12-6)13(2)3/h4-10,14-16H,1H2,2-3H3/t5-,6+,7+,8-,9+,10+/m0/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	0.220	-55.1	n/a	n/a	n/a	n/a	n/a	7.0	25
Merck Sharp & Dohme Corp. US Patent					Assay Description Enzymatic reactions are carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acety...				US Patent US8901087 (2014) BindingDB Entry DOI: 10.7270/Q24B301W
					More data for this Ligand-Target Pair
Protein O-GlcNAcase (Homo sapiens (Human))	BDBM481739 (US10913733, Example 50) Show SMILES [#6]-[#6](=O)-[#7]-c1ncc(-[#6]-[#7]-2-[#6]-[#6]\[#6](-[#6]-[#6]-2)=[#6]\c2ccc(-[#6]-[#6]-[#8])cc2)s1 Show InChI InChI=1S/C20H25N3O2S/c1-15(25)22-20-21-13-19(26-20)14-23-9-6-18(7-10-23)12-17-4-2-16(3-5-17)8-11-24/h2-5,12-13,24H,6-11,14H2,1H3,(H,21,22,25)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.241	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Alectos Therapeutics Inc.; Merck Sharp & Dohme Corp. US Patent					Assay Description Experimental procedure for kinetic analyses: Enzymatic reactions were carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (p...				US Patent US10913733 (2021) BindingDB Entry DOI: 10.7270/Q29G5QXX
					More data for this Ligand-Target Pair
Protein O-GlcNAcase (Homo sapiens (Human))	BDBM179370 (US9126957, 6) Show SMILES CNC1=N[C@H]2[C@H](C[C@H]([C@H](C)O)[C@@H](O)[C@@H]2O)O1 |t:2| Show InChI InChI=1S/C10H18N2O4/c1-4(13)5-3-6-7(9(15)8(5)14)12-10(11-2)16-6/h4-9,13-15H,3H2,1-2H3,(H,11,12)/t4-,5+,6-,7-,8+,9+/m0/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	0.260	-54.7	n/a	n/a	n/a	n/a	n/a	7.0	25
MERCK SHARP & DOHME CORP.; ALECTOS THERAPEUTICS, INC. US Patent					Assay Description Enzymatic reactions are carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acety...				US Patent US9126957 (2015) BindingDB Entry DOI: 10.7270/Q2DV1HN2
					More data for this Ligand-Target Pair
Protein O-GlcNAcase (Homo sapiens (Human))	BDBM179366 (US9126957, 2) Show SMILES C[C@H](O)[C@H]1C[C@@H]2OC(=N[C@@H]2[C@@H](O)[C@@H]1O)N(C)C |c:7| Show InChI InChI=1S/C11H20N2O4/c1-5(14)6-4-7-8(10(16)9(6)15)12-11(17-7)13(2)3/h5-10,14-16H,4H2,1-3H3/t5-,6+,7-,8-,9+,10+/m0/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	0.260	-54.7	n/a	n/a	n/a	n/a	n/a	7.0	25
MERCK SHARP & DOHME CORP.; ALECTOS THERAPEUTICS, INC. US Patent					Assay Description Enzymatic reactions are carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acety...				US Patent US9126957 (2015) BindingDB Entry DOI: 10.7270/Q2DV1HN2
					More data for this Ligand-Target Pair
Protein O-GlcNAcase (Homo sapiens (Human))	BDBM481711 (N-(5-((4-((1-oxoisoindolin- 5-yl)methylene)piperid...) Show SMILES [#6]-[#6](=O)-[#7]-c1ncc(-[#6]-[#7]-2-[#6]-[#6]\[#6](-[#6]-[#6]-2)=[#6]\c2ccc3-[#6](=O)-[#7]-[#6]-c3c2)s1 Show InChI InChI=1S/C20H22N4O2S/c1-13(25)23-20-22-11-17(27-20)12-24-6-4-14(5-7-24)8-15-2-3-18-16(9-15)10-21-19(18)26/h2-3,8-9,11H,4-7,10,12H2,1H3,(H,21,26)(H,22,23,25)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.268	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Alectos Therapeutics Inc.; Merck Sharp & Dohme Corp. US Patent					Assay Description Experimental procedure for kinetic analyses: Enzymatic reactions were carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (p...				US Patent US10913733 (2021) BindingDB Entry DOI: 10.7270/Q29G5QXX
					More data for this Ligand-Target Pair
Protein O-GlcNAcase (Homo sapiens (Human))	BDBM481727 ((S,Z)-N-(5-((4-(4- methoxybenzylidene)-2- methylpi...) Show SMILES COc1ccc(\C=C2\CCN(Cc3cnc(NC(C)=O)s3)[C@@H](C)C2)cc1 |r| Show InChI InChI=1S/C20H25N3O2S/c1-14-10-17(11-16-4-6-18(25-3)7-5-16)8-9-23(14)13-19-12-21-20(26-19)22-15(2)24/h4-7,11-12,14H,8-10,13H2,1-3H3,(H,21,22,24)/b17-11-/t14-/m0/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.287	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Alectos Therapeutics Inc.; Merck Sharp & Dohme Corp. US Patent					Assay Description Experimental procedure for kinetic analyses: Enzymatic reactions were carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (p...				US Patent US10913733 (2021) BindingDB Entry DOI: 10.7270/Q29G5QXX
					More data for this Ligand-Target Pair
Protein O-GlcNAcase (Homo sapiens (Human))	BDBM481698 (4-((1-((2-acetamidothiazol- 5-yl)methyl)-piperidin...) Show SMILES [#6]-[#6](=O)-[#7]-c1ncc(-[#6]-[#7]-2-[#6]-[#6]\[#6](-[#6]-[#6]-2)=[#6]\c2ccc(cc2)-[#6](-[#7])=O)s1 Show InChI InChI=1S/C19H22N4O2S/c1-13(24)22-19-21-11-17(26-19)12-23-8-6-15(7-9-23)10-14-2-4-16(5-3-14)18(20)25/h2-5,10-11H,6-9,12H2,1H3,(H2,20,25)(H,21,22,24)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.294	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Alectos Therapeutics Inc.; Merck Sharp & Dohme Corp. US Patent					Assay Description Experimental procedure for kinetic analyses: Enzymatic reactions were carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (p...				US Patent US10913733 (2021) BindingDB Entry DOI: 10.7270/Q29G5QXX
					More data for this Ligand-Target Pair
Protein O-GlcNAcase (Homo sapiens (Human))	BDBM139930 (US8901087, 11) Show SMILES CN(C)C1=N[C@H]2[C@H](O[C@H]([C@@H](O)C(F)(F)F)[C@@H](O)[C@@H]2O)S1 |t:3| Show InChI InChI=1S/C10H15F3N2O4S/c1-15(2)9-14-3-4(16)5(17)6(19-8(3)20-9)7(18)10(11,12)13/h3-8,16-18H,1-2H3/t3-,4-,5+,6+,7-,8-/m1/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	0.300	-54.4	n/a	n/a	n/a	n/a	n/a	7.0	25
Merck Sharp & Dohme Corp. US Patent					Assay Description Enzymatic reactions are carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acety...				US Patent US8901087 (2014) BindingDB Entry DOI: 10.7270/Q24B301W
					More data for this Ligand-Target Pair
Protein O-GlcNAcase (Homo sapiens (Human))	BDBM205418 (US9243020, (3aR,5R,6S,7R,7aR)-2-(ethylamino)-5-(hy...) Show SMILES CN(C)C1=N[C@H]2[C@H](O[C@H](CO)[C@@H](O)[C@@H]2O)S1 |r,t:3| Show InChI InChI=1S/C9H16N2O4S/c1-11(2)9-10-5-7(14)6(13)4(3-12)15-8(5)16-9/h4-8,12-14H,3H2,1-2H3/t4-,5-,6-,7-,8-/m1/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	US Patent	0.300	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Alectos Therapeutics, Inc.; Merck Sharp & Dohme Corp. US Patent					Assay Description Enzymatic reactions were carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acet...				US Patent US9815861 (2017) BindingDB Entry DOI: 10.7270/Q2R78HJ8
					More data for this Ligand-Target Pair
Protein O-GlcNAcase (Homo sapiens (Human))	BDBM205418 (US9243020, (3aR,5R,6S,7R,7aR)-2-(ethylamino)-5-(hy...) Show SMILES CN(C)C1=N[C@H]2[C@H](O[C@H](CO)[C@@H](O)[C@@H]2O)S1 |r,t:3| Show InChI InChI=1S/C9H16N2O4S/c1-11(2)9-10-5-7(14)6(13)4(3-12)15-8(5)16-9/h4-8,12-14H,3H2,1-2H3/t4-,5-,6-,7-,8-/m1/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	US Patent	0.300	-54.4	n/a	n/a	n/a	n/a	n/a	7.0	25
Alectos Therapeutics Inc.; Merck Sharp & Dohme Corp. US Patent					Assay Description Enzymatic reactions were carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acet...				US Patent US9243020 (2016) BindingDB Entry DOI: 10.7270/Q2542MD4
					More data for this Ligand-Target Pair
Protein O-GlcNAcase (Homo sapiens (Human))	BDBM481718 (US10913733, Example 29) Show SMILES [#6]-[#6](=O)-[#7]-c1ncc(-[#6]-[#7]-2-[#6]-[#6]\[#6](-[#6]-[#6]-2)=[#6]\c2ccc(cc2)-[#6](-[#8])=O)s1 Show InChI InChI=1S/C19H21N3O3S/c1-13(23)21-19-20-11-17(26-19)12-22-8-6-15(7-9-22)10-14-2-4-16(5-3-14)18(24)25/h2-5,10-11H,6-9,12H2,1H3,(H,24,25)(H,20,21,23)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.324	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Alectos Therapeutics Inc.; Merck Sharp & Dohme Corp. US Patent					Assay Description Experimental procedure for kinetic analyses: Enzymatic reactions were carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (p...				US Patent US10913733 (2021) BindingDB Entry DOI: 10.7270/Q29G5QXX
					More data for this Ligand-Target Pair
Protein O-GlcNAcase (Homo sapiens (Human))	BDBM139939 (US8901087, 57) Show SMILES CCN(C)C1=N[C@H]2[C@H](O[C@H](C(C)O)[C@@H](O)[C@@H]2O)S1 |t:4| Show InChI InChI=1S/C11H20N2O4S/c1-4-13(3)11-12-6-7(15)8(16)9(5(2)14)17-10(6)18-11/h5-10,14-16H,4H2,1-3H3/t5?,6-,7-,8+,9-,10-/m1/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	0.330	-54.1	n/a	n/a	n/a	n/a	n/a	7.0	25
Merck Sharp & Dohme Corp. US Patent					Assay Description Enzymatic reactions are carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acety...				US Patent US8901087 (2014) BindingDB Entry DOI: 10.7270/Q24B301W
					More data for this Ligand-Target Pair
Protein O-GlcNAcase (Homo sapiens (Human))	BDBM50513934 (CHEMBL4443587) Show SMILES [H][C@]12O[C@H](C(F)F)[C@@H](O)[C@H](O)[C@@]1([H])N=C(NC)S2 |r,t:14| Show InChI InChI=1S/C8H12F2N2O3S/c1-11-8-12-2-3(13)4(14)5(6(9)10)15-7(2)16-8/h2-7,13-14H,1H3,(H,11,12)/t2-,3-,4+,5+,7-/m1/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	0.360	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck & Co. Curated by ChEMBL					Assay Description Inhibition of recombinant human OGA				J Med Chem 62: 10062-10097 (2019) Article DOI: 10.1021/acs.jmedchem.9b01090 BindingDB Entry DOI: 10.7270/Q21G0QMH
					More data for this Ligand-Target Pair
Protein O-GlcNAcase (Homo sapiens (Human))	BDBM481697 (N-(5-((4-((1H-pyrazol-4- yl)methylene)piperidin-1-...) Show SMILES CC(=O)Nc1ncc(CN2CCC(CC2)=Cc2cn[nH]c2)s1 |(8.47,.15,;6.98,-.25,;6.58,-1.73,;5.89,.84,;4.41,.44,;3.64,-.89,;2.13,-.57,;1.97,.96,;.64,1.73,;-.7,.96,;-.7,-.58,;-2.03,-1.35,;-3.37,-.58,;-3.37,.96,;-2.03,1.73,;-4.7,-1.35,;-6.03,-.58,;-6.19,.95,;-7.7,1.27,;-8.47,-.06,;-7.44,-1.2,;3.38,1.59,)| Show InChI InChI=1S/C15H19N5OS/c1-11(21)19-15-16-9-14(22-15)10-20-4-2-12(3-5-20)6-13-7-17-18-8-13/h6-9H,2-5,10H2,1H3,(H,17,18)(H,16,19,21)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.387	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Alectos Therapeutics Inc.; Merck Sharp & Dohme Corp. US Patent					Assay Description Experimental procedure for kinetic analyses: Enzymatic reactions were carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (p...				US Patent US10913733 (2021) BindingDB Entry DOI: 10.7270/Q29G5QXX
					More data for this Ligand-Target Pair
Protein O-GlcNAcase (Homo sapiens (Human))	BDBM481741 (US10913733, Example 52 | US10913733, Example 54) Show SMILES C[C@H]1CC(CCN1Cc1cnc(NC(C)=O)s1)=Cc1ccc(F)nc1 |r,w:17.19| Show InChI InChI=1S/C18H21FN4OS/c1-12-7-14(8-15-3-4-17(19)20-9-15)5-6-23(12)11-16-10-21-18(25-16)22-13(2)24/h3-4,8-10,12H,5-7,11H2,1-2H3,(H,21,22,24)/t12-/m0/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.389	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Alectos Therapeutics Inc.; Merck Sharp & Dohme Corp. US Patent					Assay Description Experimental procedure for kinetic analyses: Enzymatic reactions were carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (p...				US Patent US10913733 (2021) BindingDB Entry DOI: 10.7270/Q29G5QXX
					More data for this Ligand-Target Pair
Protein O-GlcNAcase (Homo sapiens (Human))	BDBM481600 (US10913733, Example 1) Show SMILES [#6]-[#8]-c1ccc(\[#6]=[#6]-2\[#6]-[#6]-[#7](-[#6]-c3cnc(-[#7]-[#6](-[#6])=O)s3)-[#6]-[#6]-2)cc1-[#8]-[#6] Show InChI InChI=1S/C20H25N3O3S/c1-14(24)22-20-21-12-17(27-20)13-23-8-6-15(7-9-23)10-16-4-5-18(25-2)19(11-16)26-3/h4-5,10-12H,6-9,13H2,1-3H3,(H,21,22,24)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.392	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Alectos Therapeutics Inc.; Merck Sharp & Dohme Corp. US Patent					Assay Description Experimental procedure for kinetic analyses: Enzymatic reactions were carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (p...				US Patent US10913733 (2021) BindingDB Entry DOI: 10.7270/Q29G5QXX
					More data for this Ligand-Target Pair
Protein O-GlcNAcase (Homo sapiens (Human))	BDBM50323697 ((3AR,5R,6S,7R,7AR)-2-(ETHYLAMINO)-5-(HYDROXYMETHYL...) Show SMILES CCNC1=N[C@H]2[C@H](O[C@H](CO)[C@@H](O)[C@@H]2O)S1 |r,t:3| Show InChI InChI=1S/C9H16N2O4S/c1-2-10-9-11-5-7(14)6(13)4(3-12)15-8(5)16-9/h4-8,12-14H,2-3H2,1H3,(H,10,11)/t4-,5-,6-,7-,8-/m1/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Similars	PDB US Patent	0.400	-53.6	n/a	n/a	n/a	n/a	n/a	7.0	25
Alectos Therapeutics Inc.; Merck Sharp & Dohme Corp. US Patent					Assay Description Enzymatic reactions were carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acet...				US Patent US9243020 (2016) BindingDB Entry DOI: 10.7270/Q2542MD4
					More data for this Ligand-Target Pair				3D Structure (crystal)
Protein O-GlcNAcase (Homo sapiens (Human))	BDBM50323697 ((3AR,5R,6S,7R,7AR)-2-(ETHYLAMINO)-5-(HYDROXYMETHYL...) Show SMILES CCNC1=N[C@H]2[C@H](O[C@H](CO)[C@@H](O)[C@@H]2O)S1 |r,t:3| Show InChI InChI=1S/C9H16N2O4S/c1-2-10-9-11-5-7(14)6(13)4(3-12)15-8(5)16-9/h4-8,12-14H,2-3H2,1H3,(H,10,11)/t4-,5-,6-,7-,8-/m1/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Similars	PDB US Patent	0.400	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Alectos Therapeutics, Inc.; Merck Sharp & Dohme Corp. US Patent					Assay Description Enzymatic reactions were carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acet...				US Patent US9815861 (2017) BindingDB Entry DOI: 10.7270/Q2R78HJ8
					More data for this Ligand-Target Pair				3D Structure (crystal)
Protein O-GlcNAcase (Homo sapiens (Human))	BDBM50323697 ((3AR,5R,6S,7R,7AR)-2-(ETHYLAMINO)-5-(HYDROXYMETHYL...) Show SMILES CCNC1=N[C@H]2[C@H](O[C@H](CO)[C@@H](O)[C@@H]2O)S1 |r,t:3| Show InChI InChI=1S/C9H16N2O4S/c1-2-10-9-11-5-7(14)6(13)4(3-12)15-8(5)16-9/h4-8,12-14H,2-3H2,1H3,(H,10,11)/t4-,5-,6-,7-,8-/m1/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Similars	PDB US Patent	0.400	-53.6	n/a	n/a	n/a	n/a	n/a	7.0	25
Alectos Therapeutics Inc.; Merck Sharp & Dohme Corp. US Patent					Assay Description Enzymatic reactions were carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acet...				US Patent US9695197 (2017) BindingDB Entry DOI: 10.7270/Q247481J
					More data for this Ligand-Target Pair				3D Structure (crystal)
Protein O-GlcNAcase (Homo sapiens (Human))	BDBM139931 (US8901087, 13) Show SMILES CNC1=N[C@H]2[C@H](O[C@H]([C@H](C)O)[C@@H](O)[C@@H]2O)S1 |t:2| Show InChI InChI=1S/C9H16N2O4S/c1-3(12)7-6(14)5(13)4-8(15-7)16-9(10-2)11-4/h3-8,12-14H,1-2H3,(H,10,11)/t3-,4+,5+,6-,7+,8+/m0/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	0.400	-53.6	n/a	n/a	n/a	n/a	n/a	7.0	25
Merck Sharp & Dohme Corp. US Patent					Assay Description Enzymatic reactions are carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acety...				US Patent US8901087 (2014) BindingDB Entry DOI: 10.7270/Q24B301W
					More data for this Ligand-Target Pair
Protein O-GlcNAcase (Homo sapiens (Human))	BDBM50323697 ((3AR,5R,6S,7R,7AR)-2-(ETHYLAMINO)-5-(HYDROXYMETHYL...) Show SMILES CCNC1=N[C@H]2[C@H](O[C@H](CO)[C@@H](O)[C@@H]2O)S1 |r,t:3| Show InChI InChI=1S/C9H16N2O4S/c1-2-10-9-11-5-7(14)6(13)4(3-12)15-8(5)16-9/h4-8,12-14H,2-3H2,1H3,(H,10,11)/t4-,5-,6-,7-,8-/m1/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Similars	PDB Article PubMed	0.410	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck & Co. Curated by ChEMBL					Assay Description Inhibition of recombinant human OGA				J Med Chem 62: 10062-10097 (2019) Article DOI: 10.1021/acs.jmedchem.9b01090 BindingDB Entry DOI: 10.7270/Q21G0QMH
					More data for this Ligand-Target Pair				3D Structure (crystal)
Protein O-GlcNAcase (Homo sapiens (Human))	BDBM481716 (US10913733, Example 27) Show SMILES [#6]-[#6](=O)-[#7]-c1ncc(-[#6]-[#7]-2-[#6]-[#6]\[#6](-[#6]-[#6]-2)=[#6]\c2ccc(-[#6]-[#6]F)cc2)s1 Show InChI InChI=1S/C20H24FN3OS/c1-15(25)23-20-22-13-19(26-20)14-24-10-7-18(8-11-24)12-17-4-2-16(3-5-17)6-9-21/h2-5,12-13H,6-11,14H2,1H3,(H,22,23,25)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.411	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Alectos Therapeutics Inc.; Merck Sharp & Dohme Corp. US Patent					Assay Description Experimental procedure for kinetic analyses: Enzymatic reactions were carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (p...				US Patent US10913733 (2021) BindingDB Entry DOI: 10.7270/Q29G5QXX
					More data for this Ligand-Target Pair
Protein O-GlcNAcase (Homo sapiens (Human))	BDBM481708 (N-(5-{[4-(1H-indol-5- ylmethylidene)piperidin-1- y...) Show SMILES CC(=O)Nc1ncc(CN2CCC(CC2)=Cc2ccc3[nH]ccc3c2)s1 |(9.77,.15,;8.28,-.25,;7.88,-1.73,;7.19,.84,;5.71,.44,;4.94,-.89,;3.43,-.57,;3.27,.96,;1.94,1.73,;.6,.96,;.6,-.58,;-.73,-1.35,;-2.07,-.58,;-2.07,.96,;-.73,1.73,;-3.4,-1.35,;-4.73,-.58,;-4.73,.96,;-6.07,1.73,;-7.4,.96,;-8.87,1.44,;-9.77,.19,;-8.87,-1.05,;-7.4,-.58,;-6.07,-1.35,;4.68,1.59,)| Show InChI InChI=1S/C20H22N4OS/c1-14(25)23-20-22-12-18(26-20)13-24-8-5-15(6-9-24)10-16-2-3-19-17(11-16)4-7-21-19/h2-4,7,10-12,21H,5-6,8-9,13H2,1H3,(H,22,23,25)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.427	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Alectos Therapeutics Inc.; Merck Sharp & Dohme Corp. US Patent					Assay Description Experimental procedure for kinetic analyses: Enzymatic reactions were carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (p...				US Patent US10913733 (2021) BindingDB Entry DOI: 10.7270/Q29G5QXX
					More data for this Ligand-Target Pair
Protein O-GlcNAcase (Homo sapiens (Human))	BDBM481719 (US10913733, Example 30) Show SMILES [#6]-[#7]-[#6](=O)-c1ccc(\[#6]=[#6]-2\[#6]-[#6]-[#7](-[#6]-c3cnc(-[#7]-[#6](-[#6])=O)s3)-[#6]-[#6]-2)cc1 Show InChI InChI=1S/C20H24N4O2S/c1-14(25)23-20-22-12-18(27-20)13-24-9-7-16(8-10-24)11-15-3-5-17(6-4-15)19(26)21-2/h3-6,11-12H,7-10,13H2,1-2H3,(H,21,26)(H,22,23,25)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.430	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Alectos Therapeutics Inc.; Merck Sharp & Dohme Corp. US Patent					Assay Description Experimental procedure for kinetic analyses: Enzymatic reactions were carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (p...				US Patent US10913733 (2021) BindingDB Entry DOI: 10.7270/Q29G5QXX
					More data for this Ligand-Target Pair
Protein O-GlcNAcase (Homo sapiens (Human))	BDBM139961 (US8901087, 211) Show SMILES CCN(C)C1=N[C@H]2[C@H](O[C@H]([C@@H](O)C(F)(F)F)[C@@H](O)[C@@H]2O)S1 |t:4| Show InChI InChI=1S/C11H17F3N2O4S/c1-3-16(2)10-15-4-5(17)6(18)7(20-9(4)21-10)8(19)11(12,13)14/h4-9,17-19H,3H2,1-2H3/t4-,5-,6+,7+,8-,9-/m1/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	0.440	-53.4	n/a	n/a	n/a	n/a	n/a	7.0	25
Merck Sharp & Dohme Corp. US Patent					Assay Description Enzymatic reactions are carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acety...				US Patent US8901087 (2014) BindingDB Entry DOI: 10.7270/Q24B301W
					More data for this Ligand-Target Pair
Protein O-GlcNAcase (Homo sapiens (Human))	BDBM139942 (US8901087, 65) Show SMILES CN(C)C1=N[C@H]2[C@H](O[C@H]([C@@H](O)C(C)=C)[C@@H](O)[C@@H]2O)S1 |t:3| Show InChI InChI=1S/C12H20N2O4S/c1-5(2)7(15)10-9(17)8(16)6-11(18-10)19-12(13-6)14(3)4/h6-11,15-17H,1H2,2-4H3/t6-,7+,8-,9+,10-,11-/m1/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	0.450	-53.3	n/a	n/a	n/a	n/a	n/a	7.0	25
Merck Sharp & Dohme Corp. US Patent					Assay Description Enzymatic reactions are carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acety...				US Patent US8901087 (2014) BindingDB Entry DOI: 10.7270/Q24B301W
					More data for this Ligand-Target Pair
Protein O-GlcNAcase (Homo sapiens (Human))	BDBM314781 ((3aR,5S,6S,7R,7aR)-2- (dimethylamino)-5-((R)-2,2,2...) Show SMILES COc1c(C)cc(CO[C@H]([C@H]2O[C@@H]3SC(=N[C@@H]3[C@@H](O)[C@@H]2O)N(C)C)C(F)(F)F)cc1C |c:14| Show InChI InChI=1S/C20H27F3N2O5S/c1-9-6-11(7-10(2)15(9)28-5)8-29-17(20(21,22)23)16-14(27)13(26)12-18(30-16)31-19(24-12)25(3)4/h6-7,12-14,16-18,26-27H,8H2,1-5H3/t12-,13-,14+,16+,17-,18-/m1/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.450	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
ALECTOS THERAPEUTICS, INC.; MERCK SHARP & DOHME CORP. US Patent					Assay Description Enzymatic reactions were carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acet...				US Patent US9611275 (2017) BindingDB Entry DOI: 10.7270/Q2833V4D
					More data for this Ligand-Target Pair
Protein O-GlcNAcase (Homo sapiens (Human))	BDBM205423 (US9243020, 17 | US9815861, Example 17) Show SMILES CNC1=N[C@H]2[C@H](O[C@H](CF)[C@@H](O)[C@@H]2O)S1 |r,t:2| Show InChI InChI=1S/C8H13FN2O3S/c1-10-8-11-4-6(13)5(12)3(2-9)14-7(4)15-8/h3-7,12-13H,2H2,1H3,(H,10,11)/t3-,4-,5-,6-,7-/m1/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Alectos Therapeutics, Inc.; Merck Sharp & Dohme Corp. US Patent					Assay Description Enzymatic reactions were carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acet...				US Patent US9815861 (2017) BindingDB Entry DOI: 10.7270/Q2R78HJ8
					More data for this Ligand-Target Pair
Protein O-GlcNAcase (Homo sapiens (Human))	BDBM205423 (US9243020, 17 | US9815861, Example 17) Show SMILES CNC1=N[C@H]2[C@H](O[C@H](CF)[C@@H](O)[C@@H]2O)S1 |r,t:2| Show InChI InChI=1S/C8H13FN2O3S/c1-10-8-11-4-6(13)5(12)3(2-9)14-7(4)15-8/h3-7,12-13H,2H2,1H3,(H,10,11)/t3-,4-,5-,6-,7-/m1/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.5	-53.1	n/a	n/a	n/a	n/a	n/a	7.0	25
Alectos Therapeutics Inc.; Merck Sharp & Dohme Corp. US Patent					Assay Description Enzymatic reactions were carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acet...				US Patent US9243020 (2016) BindingDB Entry DOI: 10.7270/Q2542MD4
					More data for this Ligand-Target Pair
Protein O-GlcNAcase (Homo sapiens (Human))	BDBM139948 (US8901087, 80) Show SMILES O[C@@H](C=C)[C@H]1O[C@@H]2SC(=N[C@@H]2[C@@H](O)[C@@H]1O)N1CCC1 |c:8| Show InChI InChI=1S/C12H18N2O4S/c1-2-6(15)10-9(17)8(16)7-11(18-10)19-12(13-7)14-4-3-5-14/h2,6-11,15-17H,1,3-5H2/t6-,7+,8+,9-,10+,11+/m0/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	0.5	-53.1	n/a	n/a	n/a	n/a	n/a	7.0	25
Merck Sharp & Dohme Corp. US Patent					Assay Description Enzymatic reactions are carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acety...				US Patent US8901087 (2014) BindingDB Entry DOI: 10.7270/Q24B301W
					More data for this Ligand-Target Pair
Protein O-GlcNAcase (Homo sapiens (Human))	BDBM177756 (US9120781, 22) Show SMILES CN(C)C1=N[C@H]2[C@H](C[C@H](CO)[C@@H](O)[C@@H]2O)S1 |r,t:3| Show InChI InChI=1S/C10H18N2O3S/c1-12(2)10-11-7-6(16-10)3-5(4-13)8(14)9(7)15/h5-9,13-15H,3-4H2,1-2H3/t5-,6+,7+,8-,9-/m1/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	0.5	-53.1	n/a	n/a	n/a	n/a	n/a	7.0	25
Simon Fraser University; Merck Sharp & Dohme Corp.; Alectos Therapeutics Inc. US Patent					Assay Description Enzymatic reactions are carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acety...				US Patent US9120781 (2015) BindingDB Entry DOI: 10.7270/Q2DZ072S
					More data for this Ligand-Target Pair
Protein O-GlcNAcase (Homo sapiens (Human))	BDBM139950 (US8901087, 91) Show SMILES C[C@H](O)[C@H]1O[C@@H]2SC(=N[C@@H]2[C@@H](O)[C@@H]1O)N1CCCC1 |c:7| Show InChI InChI=1S/C12H20N2O4S/c1-6(15)10-9(17)8(16)7-11(18-10)19-12(13-7)14-4-2-3-5-14/h6-11,15-17H,2-5H2,1H3/t6-,7+,8+,9-,10+,11+/m0/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	0.530	-52.9	n/a	n/a	n/a	n/a	n/a	7.0	25
Merck Sharp & Dohme Corp. US Patent					Assay Description Enzymatic reactions are carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acety...				US Patent US8901087 (2014) BindingDB Entry DOI: 10.7270/Q24B301W
					More data for this Ligand-Target Pair

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