BindingDB PrimarySearch

Found 16 hits with Last Name = 'mckenna' and Initial = 'ce'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Farnesyl pyrophosphate synthase (Homo sapiens (Human))	BDBM25308 ((1-hydroxy-2-{imidazo[1,2-a]pyridin-3-yl}-1-phosph...) Show SMILES OC(Cc1cnc2ccccn12)(P(O)(O)=O)P(O)(O)=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
University of Southern California Curated by ChEMBL					Assay Description Inhibition of human FPPS after 10 mins using [14C]IPP as substrate by liquid scintillation counting				J Med Chem 53: 3454-64 (2010) Checked by Author Article DOI: 10.1021/jm900232u BindingDB Entry DOI: 10.7270/Q21837FJ
University of Southern California Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Farnesyl pyrophosphate synthase (Homo sapiens (Human))	BDBM12576 (Bisphosphonate 1 \| CHEMBL923 \| JMC515594 Compound ...) Show SMILES OC(Cc1cccnc1)(P(O)(O)=O)P(O)(O)=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank MMDB PDB Article PubMed	n/a	n/a	5.70	n/a	n/a	n/a	n/a	n/a	n/a
University of Southern California Curated by ChEMBL					Assay Description Inhibition of human FPPS				Bioorg Med Chem Lett 18: 2878-82 (2008) Article DOI: 10.1016/j.bmcl.2008.03.088 BindingDB Entry DOI: 10.7270/Q2WM1F9P
University of Southern California Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Farnesyl pyrophosphate synthase (Homo sapiens (Human))	BDBM50225999 (1-fluoro-2-(3-pyridinyl)-ethylidene-1,1-bisphospho...) Show SMILES OP(O)(=O)C(F)(Cc1cccnc1)P(O)(O)=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	16.4	n/a	n/a	n/a	n/a	n/a	n/a
University of Southern California Curated by ChEMBL					Assay Description Inhibition of human cloned FPPS expressed in Escherichia col BL2 (DE3)				J Med Chem 50: 5967-75 (2007) Article DOI: 10.1021/jm0702884 BindingDB Entry DOI: 10.7270/Q27944DF
University of Southern California Curated by ChEMBL					More data for this Ligand-Target Pair
Farnesyl pyrophosphate synthase (Homo sapiens (Human))	BDBM50138725 ((1-phosphono-2-pyridin-3-yl-ethyl)-phosphonic acid...) Show SMILES OP(O)(=O)C(Cc1cccnc1)P(O)(O)=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	34.2	n/a	n/a	n/a	n/a	n/a	n/a
University of Southern California Curated by ChEMBL					Assay Description Inhibition of human cloned FPPS expressed in Escherichia col BL2 (DE3)				J Med Chem 50: 5967-75 (2007) Article DOI: 10.1021/jm0702884 BindingDB Entry DOI: 10.7270/Q27944DF
University of Southern California Curated by ChEMBL					More data for this Ligand-Target Pair
Farnesyl pyrophosphate synthase (Homo sapiens (Human))	BDBM50225995 (1-chloro-2-(3-pyridinyl)-ethylidene-1,1-bisphospho...) Show SMILES OP(O)(=O)C(Cl)(Cc1cccnc1)P(O)(O)=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	94.6	n/a	n/a	n/a	n/a	n/a	n/a
University of Southern California Curated by ChEMBL					Assay Description Inhibition of human cloned FPPS expressed in Escherichia col BL2 (DE3)				J Med Chem 50: 5967-75 (2007) Article DOI: 10.1021/jm0702884 BindingDB Entry DOI: 10.7270/Q27944DF
University of Southern California Curated by ChEMBL					More data for this Ligand-Target Pair
Farnesyl pyrophosphate synthase (Homo sapiens (Human))	BDBM50225997 (1-bromo-2-(3-pyridinyl)-ethylidene-1,1-bisphosphon...) Show SMILES OP(O)(=O)C(Br)(Cc1cccnc1)P(O)(O)=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	340	n/a	n/a	n/a	n/a	n/a	n/a
University of Southern California Curated by ChEMBL					Assay Description Inhibition of human cloned FPPS expressed in Escherichia col BL2 (DE3)				J Med Chem 50: 5967-75 (2007) Article DOI: 10.1021/jm0702884 BindingDB Entry DOI: 10.7270/Q27944DF
University of Southern California Curated by ChEMBL					More data for this Ligand-Target Pair
Farnesyl pyrophosphate synthase (Homo sapiens (Human))	BDBM50377836 (CHEMBL317573) Show SMILES OC(C1CCc2ccncc12)(P(O)(O)=O)P(O)(O)=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	630	n/a	n/a	n/a	n/a	n/a	n/a
University of Southern California Curated by ChEMBL					Assay Description Inhibition of human FPPS				Bioorg Med Chem Lett 18: 2878-82 (2008) Article DOI: 10.1016/j.bmcl.2008.03.088 BindingDB Entry DOI: 10.7270/Q2WM1F9P
University of Southern California Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Geranylgeranyl pyrophosphate synthase (Homo sapiens (Human))	BDBM25308 ((1-hydroxy-2-{imidazo[1,2-a]pyridin-3-yl}-1-phosph...) Show SMILES OC(Cc1cnc2ccccn12)(P(O)(O)=O)P(O)(O)=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	670	n/a	n/a	n/a	n/a	n/a	n/a
University of Southern California Curated by ChEMBL					Assay Description Inhibition of GGPPS after 10 mins using [14C]IPP as substrate by liquid scintillation counting				J Med Chem 53: 3454-64 (2010) Checked by Author Article DOI: 10.1021/jm900232u BindingDB Entry DOI: 10.7270/Q21837FJ
University of Southern California Curated by ChEMBL					More data for this Ligand-Target Pair
Farnesyl pyrophosphate synthase (Homo sapiens (Human))	BDBM50318032 ((+)-2-hydroxy-3-imidazo[1,2-a]pyridin-3-yl-2-phosp...) Show SMILES OC(=O)C(O)(Cc1cnc2ccccn12)P(O)(O)=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Southern California Curated by ChEMBL					Assay Description Inhibition of human FPPS after 10 mins using [14C]IPP as substrate by liquid scintillation counting				J Med Chem 53: 3454-64 (2010) Checked by Author Article DOI: 10.1021/jm900232u BindingDB Entry DOI: 10.7270/Q21837FJ
University of Southern California Curated by ChEMBL					More data for this Ligand-Target Pair
Farnesyl pyrophosphate synthase (Homo sapiens (Human))	BDBM50226001 (2-bromo-3-(3-pyridinyl)-2-phosphonopropionic acid ...) Show SMILES OC(=O)C(Br)(Cc1cccnc1)P(O)(O)=O \|w:3.3\| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>6.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Southern California Curated by ChEMBL					Assay Description Inhibition of human cloned FPPS expressed in Escherichia col BL2 (DE3)				J Med Chem 50: 5967-75 (2007) Article DOI: 10.1021/jm0702884 BindingDB Entry DOI: 10.7270/Q27944DF
University of Southern California Curated by ChEMBL					More data for this Ligand-Target Pair
Farnesyl pyrophosphate synthase (Homo sapiens (Human))	BDBM50226002 ((R)-2-hydroxy-2-phosphono-3-(pyridin-3-yl)propanoi...) Show SMILES OC(=O)C(O)(Cc1cccnc1)P(O)(O)=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.54E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Southern California Curated by ChEMBL					Assay Description Inhibition of human cloned FPPS expressed in Escherichia col BL2 (DE3)				J Med Chem 50: 5967-75 (2007) Article DOI: 10.1021/jm0702884 BindingDB Entry DOI: 10.7270/Q27944DF
University of Southern California Curated by ChEMBL					More data for this Ligand-Target Pair
Farnesyl pyrophosphate synthase (Homo sapiens (Human))	BDBM50225998 (2-chloro-3-(3-pyridinyl)-2-phosphonopropionic acid...) Show SMILES OC(=O)C(Cl)(Cc1cccnc1)P(O)(O)=O \|w:3.3\| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>6.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Southern California Curated by ChEMBL					Assay Description Inhibition of human cloned FPPS expressed in Escherichia col BL2 (DE3)				J Med Chem 50: 5967-75 (2007) Article DOI: 10.1021/jm0702884 BindingDB Entry DOI: 10.7270/Q27944DF
University of Southern California Curated by ChEMBL					More data for this Ligand-Target Pair
Farnesyl pyrophosphate synthase (Homo sapiens (Human))	BDBM50226000 (2-fluoro-3-(3-pyridinyl)-2-phosphonopropionic acid...) Show SMILES OC(=O)C(F)(Cc1cccnc1)P(O)(O)=O \|w:3.3\| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>6.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Southern California Curated by ChEMBL					Assay Description Inhibition of human cloned FPPS expressed in Escherichia col BL2 (DE3)				J Med Chem 50: 5967-75 (2007) Article DOI: 10.1021/jm0702884 BindingDB Entry DOI: 10.7270/Q27944DF
University of Southern California Curated by ChEMBL					More data for this Ligand-Target Pair
Geranylgeranyl pyrophosphate synthase (Homo sapiens (Human))	BDBM50318032 ((+)-2-hydroxy-3-imidazo[1,2-a]pyridin-3-yl-2-phosp...) Show SMILES OC(=O)C(O)(Cc1cnc2ccccn12)P(O)(O)=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	>1.00E+6	n/a	n/a	n/a	n/a	n/a	n/a
University of Southern California Curated by ChEMBL					Assay Description Inhibition of GGPPS after 10 mins using [14C]IPP as substrate by liquid scintillation counting				J Med Chem 53: 3454-64 (2010) Checked by Author Article DOI: 10.1021/jm900232u BindingDB Entry DOI: 10.7270/Q21837FJ
University of Southern California Curated by ChEMBL					More data for this Ligand-Target Pair
Geranylgeranyl pyrophosphate synthase (Homo sapiens (Human))	BDBM50318032 ((+)-2-hydroxy-3-imidazo[1,2-a]pyridin-3-yl-2-phosp...) Show SMILES OC(=O)C(O)(Cc1cnc2ccccn12)P(O)(O)=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	>1.00E+6	n/a	n/a	n/a	n/a	n/a	n/a
University of Southern California Curated by ChEMBL					Assay Description Inhibition of GGPPS after 10 mins using [14C]IPP as substrate by liquid scintillation counting				J Med Chem 53: 3454-64 (2010) Checked by Author Article DOI: 10.1021/jm900232u BindingDB Entry DOI: 10.7270/Q21837FJ
University of Southern California Curated by ChEMBL					More data for this Ligand-Target Pair
Farnesyl pyrophosphate synthase (Homo sapiens (Human))	BDBM50226002 ((R)-2-hydroxy-2-phosphono-3-(pyridin-3-yl)propanoi...) Show SMILES OC(=O)C(O)(Cc1cccnc1)P(O)(O)=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+6	n/a	n/a	n/a	n/a	n/a	n/a
University of Southern California Curated by ChEMBL					Assay Description Inhibition of human FPPS after 10 mins using [14C]IPP as substrate by liquid scintillation counting				J Med Chem 53: 3454-64 (2010) Checked by Author Article DOI: 10.1021/jm900232u BindingDB Entry DOI: 10.7270/Q21837FJ
University of Southern California Curated by ChEMBL					More data for this Ligand-Target Pair