Found 1183 hits with Last Name = 'mcnally' and Initial = 'jj' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50147083
(1-(4-tert-Butyl-benzyl)-3-isoquinolin-5-yl-urea | ...)Show InChI InChI=1S/C21H23N3O/c1-21(2,3)17-9-7-15(8-10-17)13-23-20(25)24-19-6-4-5-16-14-22-12-11-18(16)19/h4-12,14H,13H2,1-3H3,(H2,23,24,25) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 0.300 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Binding affinity towards human vanilloid receptor subtype 1 expressed in HEK293 cell membrane using [3H]-RTX as radioligand. |
Bioorg Med Chem Lett 14: 3053-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.04.038
BindingDB Entry DOI: 10.7270/Q2FB52D6 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50147069
(1-(4-Chloro-3-trifluoromethyl-benzyl)-3-isoquinoli...)Show InChI InChI=1S/C18H13ClF3N3O/c19-15-5-4-11(8-14(15)18(20,21)22)9-24-17(26)25-16-3-1-2-12-10-23-7-6-13(12)16/h1-8,10H,9H2,(H2,24,25,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 0.800 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Binding affinity towards human vanilloid receptor subtype 1 expressed in HEK293 cell membrane using [3H]-RTX as radioligand. |
Bioorg Med Chem Lett 14: 3053-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.04.038
BindingDB Entry DOI: 10.7270/Q2FB52D6 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50223336
(1-(1-(cyclopropylmethyl)-6-fluoro-1,2,3,4-tetrahyd...)Show SMILES Fc1ccc2C(CC3CC3)C(CCc2c1)NC(=O)Nc1cccc2cnccc12 |w:5.5,10.17| Show InChI InChI=1S/C24H24FN3O/c25-18-7-8-19-16(13-18)6-9-23(21(19)12-15-4-5-15)28-24(29)27-22-3-1-2-17-14-26-11-10-20(17)22/h1-3,7-8,10-11,13-15,21,23H,4-6,9,12H2,(H2,27,28,29) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 0.800 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Displacement of [3H]RTX from human TRPV1 expressed in HEK293 cells |
Bioorg Med Chem Lett 17: 6160-3 (2007)
Article DOI: 10.1016/j.bmcl.2007.09.036
BindingDB Entry DOI: 10.7270/Q28G8KFT |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50223314
(1-(1-(4-(trifluoromethyl)benzyl)-6-fluoro-1,2,3,4-...)Show SMILES Fc1ccc2C(Cc3ccc(cc3)C(F)(F)F)C(CCc2c1)NC(=O)Nc1cccc2cnccc12 |w:5.5,17.24| Show InChI InChI=1S/C28H23F4N3O/c29-21-9-10-22-18(15-21)6-11-26(24(22)14-17-4-7-20(8-5-17)28(30,31)32)35-27(36)34-25-3-1-2-19-16-33-13-12-23(19)25/h1-5,7-10,12-13,15-16,24,26H,6,11,14H2,(H2,34,35,36) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Displacement of [3H]RTX from human TRPV1 expressed in HEK293 cells |
Bioorg Med Chem Lett 17: 6160-3 (2007)
Article DOI: 10.1016/j.bmcl.2007.09.036
BindingDB Entry DOI: 10.7270/Q28G8KFT |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50223313
(1-(1-(4-bromobenzyl)-6-methoxy-1,2,3,4-tetrahydron...)Show SMILES COc1ccc2C(Cc3ccc(Br)cc3)C(CCc2c1)NC(=O)Nc1cccc2cnccc12 |w:6.6,15.22| Show InChI InChI=1S/C28H26BrN3O2/c1-34-22-10-11-23-19(16-22)7-12-27(25(23)15-18-5-8-21(29)9-6-18)32-28(33)31-26-4-2-3-20-17-30-14-13-24(20)26/h2-6,8-11,13-14,16-17,25,27H,7,12,15H2,1H3,(H2,31,32,33) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Displacement of [3H]RTX from human TRPV1 expressed in HEK293 cells |
Bioorg Med Chem Lett 17: 6160-3 (2007)
Article DOI: 10.1016/j.bmcl.2007.09.036
BindingDB Entry DOI: 10.7270/Q28G8KFT |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50147080
(3-(4-tert-Butyl-phenyl)-N-isoquinolin-5-yl-acrylam...)Show SMILES CC(C)(C)c1ccc(\C=C\C(=O)Nc2cccc3cnccc23)cc1 Show InChI InChI=1S/C22H22N2O/c1-22(2,3)18-10-7-16(8-11-18)9-12-21(25)24-20-6-4-5-17-15-23-14-13-19(17)20/h4-15H,1-3H3,(H,24,25)/b12-9+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 1.20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Antagonistic activity towards human vanilloid receptor subtype 1 expressed in HEK293 cell membrane, as inhibition of agonist-induced intracellular [C... |
Bioorg Med Chem Lett 14: 3053-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.04.038
BindingDB Entry DOI: 10.7270/Q2FB52D6 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50147063
(1-Isoquinolin-5-yl-3-(4-trifluoromethoxy-benzyl)-u...)Show InChI InChI=1S/C18H14F3N3O2/c19-18(20,21)26-14-6-4-12(5-7-14)10-23-17(25)24-16-3-1-2-13-11-22-9-8-15(13)16/h1-9,11H,10H2,(H2,23,24,25) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 1.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Binding affinity towards human vanilloid receptor subtype 1 expressed in HEK293 cell membrane using [3H]-RTX as radioligand. |
Bioorg Med Chem Lett 14: 3053-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.04.038
BindingDB Entry DOI: 10.7270/Q2FB52D6 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50147067
(1-[2-(4-tert-Butyl-phenyl)-ethyl]-3-isoquinolin-5-...)Show InChI InChI=1S/C22H25N3O/c1-22(2,3)18-9-7-16(8-10-18)11-14-24-21(26)25-20-6-4-5-17-15-23-13-12-19(17)20/h4-10,12-13,15H,11,14H2,1-3H3,(H2,24,25,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 1.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Binding affinity towards human vanilloid receptor subtype 1 expressed in HEK293 cell membrane using [3H]-RTX as radioligand. |
Bioorg Med Chem Lett 14: 3053-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.04.038
BindingDB Entry DOI: 10.7270/Q2FB52D6 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50147077
(1-(3,5-Bis-trifluoromethyl-phenyl)-3-isoquinolin-5...)Show SMILES FC(F)(F)c1cc(NC(=O)Nc2cccc3cnccc23)cc(c1)C(F)(F)F Show InChI InChI=1S/C18H11F6N3O/c19-17(20,21)11-6-12(18(22,23)24)8-13(7-11)26-16(28)27-15-3-1-2-10-9-25-5-4-14(10)15/h1-9H,(H2,26,27,28) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 1.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Antagonistic activity towards human vanilloid receptor subtype 1 expressed in HEK293 cell membrane, as inhibition of agonist-induced intracellular [C... |
Bioorg Med Chem Lett 14: 3053-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.04.038
BindingDB Entry DOI: 10.7270/Q2FB52D6 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50223331
(1-(1-benzyl-6-bromo-1,2,3,4-tetrahydronaphthalen-2...)Show SMILES Brc1ccc2C(Cc3ccccc3)C(CCc2c1)NC(=O)Nc1cccc2cnccc12 |w:5.5,13.20| Show InChI InChI=1S/C27H24BrN3O/c28-21-10-11-22-19(16-21)9-12-26(24(22)15-18-5-2-1-3-6-18)31-27(32)30-25-8-4-7-20-17-29-14-13-23(20)25/h1-8,10-11,13-14,16-17,24,26H,9,12,15H2,(H2,30,31,32) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 2 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Displacement of [3H]RTX from human TRPV1 expressed in HEK293 cells |
Bioorg Med Chem Lett 17: 6160-3 (2007)
Article DOI: 10.1016/j.bmcl.2007.09.036
BindingDB Entry DOI: 10.7270/Q28G8KFT |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50223328
(1-(1-benzyl-5-chloro-1,2,3,4-tetrahydronaphthalen-...)Show SMILES Clc1cccc2C(Cc3ccccc3)C(CCc12)NC(=O)Nc1cccc2cnccc12 |w:6.6,14.20| Show InChI InChI=1S/C27H24ClN3O/c28-24-10-5-9-21-22(24)12-13-26(23(21)16-18-6-2-1-3-7-18)31-27(32)30-25-11-4-8-19-17-29-15-14-20(19)25/h1-11,14-15,17,23,26H,12-13,16H2,(H2,30,31,32) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 2 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Displacement of [3H]RTX from human TRPV1 expressed in HEK293 cells |
Bioorg Med Chem Lett 17: 6160-3 (2007)
Article DOI: 10.1016/j.bmcl.2007.09.036
BindingDB Entry DOI: 10.7270/Q28G8KFT |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50223321
(1-(1-(3-chlorobenzyl)-6-methoxy-1,2,3,4-tetrahydro...)Show SMILES COc1ccc2C(Cc3cccc(Cl)c3)C(CCc2c1)NC(=O)Nc1cccc2cnccc12 |w:6.6,15.22| Show InChI InChI=1S/C28H26ClN3O2/c1-34-22-9-10-23-19(16-22)8-11-27(25(23)15-18-4-2-6-21(29)14-18)32-28(33)31-26-7-3-5-20-17-30-13-12-24(20)26/h2-7,9-10,12-14,16-17,25,27H,8,11,15H2,1H3,(H2,31,32,33) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 2 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Displacement of [3H]RTX from human TRPV1 expressed in HEK293 cells |
Bioorg Med Chem Lett 17: 6160-3 (2007)
Article DOI: 10.1016/j.bmcl.2007.09.036
BindingDB Entry DOI: 10.7270/Q28G8KFT |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50223338
(1-(1-(4-(trifluoromethyl)benzyl)-6-methoxy-1,2,3,4...)Show SMILES COc1ccc2C(Cc3ccc(cc3)C(F)(F)F)C(CCc2c1)NC(=O)Nc1cccc2cnccc12 |w:6.6,18.25| Show InChI InChI=1S/C29H26F3N3O2/c1-37-22-10-11-23-19(16-22)7-12-27(25(23)15-18-5-8-21(9-6-18)29(30,31)32)35-28(36)34-26-4-2-3-20-17-33-14-13-24(20)26/h2-6,8-11,13-14,16-17,25,27H,7,12,15H2,1H3,(H2,34,35,36) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 2 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Displacement of [3H]RTX from human TRPV1 expressed in HEK293 cells |
Bioorg Med Chem Lett 17: 6160-3 (2007)
Article DOI: 10.1016/j.bmcl.2007.09.036
BindingDB Entry DOI: 10.7270/Q28G8KFT |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50223330
(1-(1-allyl-6-fluoro-1,2,3,4-tetrahydronaphthalen-2...)Show SMILES Fc1ccc2C(CC=C)C(CCc2c1)NC(=O)Nc1cccc2cnccc12 |w:5.5,9.15| Show InChI InChI=1S/C23H22FN3O/c1-2-4-20-18-9-8-17(24)13-15(18)7-10-22(20)27-23(28)26-21-6-3-5-16-14-25-12-11-19(16)21/h2-3,5-6,8-9,11-14,20,22H,1,4,7,10H2,(H2,26,27,28) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 2 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Displacement of [3H]RTX from human TRPV1 expressed in HEK293 cells |
Bioorg Med Chem Lett 17: 6160-3 (2007)
Article DOI: 10.1016/j.bmcl.2007.09.036
BindingDB Entry DOI: 10.7270/Q28G8KFT |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50223333
(1-(1-benzyl-6-methoxy-1,2,3,4-tetrahydronaphthalen...)Show SMILES COc1ccc2C(Cc3ccccc3)C(CCc2c1)NC(=O)Nc1cccc2cnccc12 |w:6.6,14.21| Show InChI InChI=1S/C28H27N3O2/c1-33-22-11-12-23-20(17-22)10-13-27(25(23)16-19-6-3-2-4-7-19)31-28(32)30-26-9-5-8-21-18-29-15-14-24(21)26/h2-9,11-12,14-15,17-18,25,27H,10,13,16H2,1H3,(H2,30,31,32) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Displacement of [3H]RTX from human TRPV1 expressed in HEK293 cells |
Bioorg Med Chem Lett 17: 6160-3 (2007)
Article DOI: 10.1016/j.bmcl.2007.09.036
BindingDB Entry DOI: 10.7270/Q28G8KFT |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50223315
(1-(6-fluoro-1-(thiophen-2-ylmethyl)-1,2,3,4-tetrah...)Show SMILES Fc1ccc2C(Cc3cccs3)C(CCc2c1)NC(=O)Nc1cccc2cnccc12 |w:5.5,12.19| Show InChI InChI=1S/C25H22FN3OS/c26-18-7-8-20-16(13-18)6-9-24(22(20)14-19-4-2-12-31-19)29-25(30)28-23-5-1-3-17-15-27-11-10-21(17)23/h1-5,7-8,10-13,15,22,24H,6,9,14H2,(H2,28,29,30) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Displacement of [3H]RTX from human TRPV1 expressed in HEK293 cells |
Bioorg Med Chem Lett 17: 6160-3 (2007)
Article DOI: 10.1016/j.bmcl.2007.09.036
BindingDB Entry DOI: 10.7270/Q28G8KFT |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50223340
(1-(1-benzyl-6-fluoro-1,2,3,4-tetrahydronaphthalen-...)Show SMILES Fc1ccc2C(Cc3ccccc3)C(CCc2c1)NC(=O)Nc1cccc2cnccc12 |w:5.5,13.20| Show InChI InChI=1S/C27H24FN3O/c28-21-10-11-22-19(16-21)9-12-26(24(22)15-18-5-2-1-3-6-18)31-27(32)30-25-8-4-7-20-17-29-14-13-23(20)25/h1-8,10-11,13-14,16-17,24,26H,9,12,15H2,(H2,30,31,32) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Displacement of [3H]RTX from human TRPV1 expressed in HEK293 cells |
Bioorg Med Chem Lett 17: 6160-3 (2007)
Article DOI: 10.1016/j.bmcl.2007.09.036
BindingDB Entry DOI: 10.7270/Q28G8KFT |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50223323
(1-(isoquinolin-5-yl)-3-(3-phenyl-2-(4-(trifluorome...)Show SMILES FC(F)(F)c1ccc(cc1)C(CNC(=O)Nc1cccc2cnccc12)Cc1ccccc1 |w:10.11| Show InChI InChI=1S/C26H22F3N3O/c27-26(28,29)22-11-9-19(10-12-22)21(15-18-5-2-1-3-6-18)17-31-25(33)32-24-8-4-7-20-16-30-14-13-23(20)24/h1-14,16,21H,15,17H2,(H2,31,32,33) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Displacement of [3H]RTX from human TRPV1 expressed in HEK293 cells |
Bioorg Med Chem Lett 17: 6160-3 (2007)
Article DOI: 10.1016/j.bmcl.2007.09.036
BindingDB Entry DOI: 10.7270/Q28G8KFT |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50147060
(3-[4-(1,1-Dimethyl-propyl)-phenyl]-N-isoquinolin-5...)Show InChI InChI=1S/C23H26N2O/c1-4-23(2,3)19-11-8-17(9-12-19)10-13-22(26)25-21-7-5-6-18-16-24-15-14-20(18)21/h5-9,11-12,14-16H,4,10,13H2,1-3H3,(H,25,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Binding affinity towards human vanilloid receptor subtype 1 expressed in HEK293 cell membrane using [3H]-RTX as radioligand. |
Bioorg Med Chem Lett 14: 3053-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.04.038
BindingDB Entry DOI: 10.7270/Q2FB52D6 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50223335
(1-(1-benzyl-1,2,3,4-tetrahydronaphthalen-2-yl)-3-(...)Show SMILES O=C(NC1CCc2ccccc2C1Cc1ccccc1)Nc1cccc2cnccc12 |w:12.14,3.2| Show InChI InChI=1S/C27H25N3O/c31-27(29-25-12-6-10-21-18-28-16-15-23(21)25)30-26-14-13-20-9-4-5-11-22(20)24(26)17-19-7-2-1-3-8-19/h1-12,15-16,18,24,26H,13-14,17H2,(H2,29,30,31) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Displacement of [3H]RTX from human TRPV1 expressed in HEK293 cells |
Bioorg Med Chem Lett 17: 6160-3 (2007)
Article DOI: 10.1016/j.bmcl.2007.09.036
BindingDB Entry DOI: 10.7270/Q28G8KFT |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50223316
(1-(1-benzyl-7-chloro-1,2,3,4-tetrahydronaphthalen-...)Show SMILES Clc1ccc2CCC(NC(=O)Nc3cccc4cnccc34)C(Cc3ccccc3)c2c1 |w:22.24,7.7| Show InChI InChI=1S/C27H24ClN3O/c28-21-11-9-19-10-12-26(24(23(19)16-21)15-18-5-2-1-3-6-18)31-27(32)30-25-8-4-7-20-17-29-14-13-22(20)25/h1-9,11,13-14,16-17,24,26H,10,12,15H2,(H2,30,31,32) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Displacement of [3H]RTX from human TRPV1 expressed in HEK293 cells |
Bioorg Med Chem Lett 17: 6160-3 (2007)
Article DOI: 10.1016/j.bmcl.2007.09.036
BindingDB Entry DOI: 10.7270/Q28G8KFT |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM20334
(1-Isoquinolin-5-yl-3-(4-trifluoromethyl-benzyl)-ur...)Show InChI InChI=1S/C18H14F3N3O/c19-18(20,21)14-6-4-12(5-7-14)10-23-17(25)24-16-3-1-2-13-11-22-9-8-15(13)16/h1-9,11H,10H2,(H2,23,24,25) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Binding affinity towards human vanilloid receptor subtype 1 expressed in HEK293 cell membrane using [3H]-RTX as radioligand. |
Bioorg Med Chem Lett 14: 3053-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.04.038
BindingDB Entry DOI: 10.7270/Q2FB52D6 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50147081
(1-Isoquinolin-5-yl-3-[2-(4-trifluoromethoxy-phenyl...)Show InChI InChI=1S/C19H16F3N3O2/c20-19(21,22)27-15-6-4-13(5-7-15)8-11-24-18(26)25-17-3-1-2-14-12-23-10-9-16(14)17/h1-7,9-10,12H,8,11H2,(H2,24,25,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Binding affinity towards human vanilloid receptor subtype 1 expressed in HEK293 cell membrane using [3H]-RTX as radioligand. |
Bioorg Med Chem Lett 14: 3053-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.04.038
BindingDB Entry DOI: 10.7270/Q2FB52D6 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50223337
(1-(isoquinolin-5-yl)-3-(2-(4-methoxyphenyl)-3-phen...)Show SMILES COc1ccc(cc1)C(CNC(=O)Nc1cccc2cnccc12)Cc1ccccc1 |w:8.9| Show InChI InChI=1S/C26H25N3O2/c1-31-23-12-10-20(11-13-23)22(16-19-6-3-2-4-7-19)18-28-26(30)29-25-9-5-8-21-17-27-15-14-24(21)25/h2-15,17,22H,16,18H2,1H3,(H2,28,29,30) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Displacement of [3H]RTX from human TRPV1 expressed in HEK293 cells |
Bioorg Med Chem Lett 17: 6160-3 (2007)
Article DOI: 10.1016/j.bmcl.2007.09.036
BindingDB Entry DOI: 10.7270/Q28G8KFT |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50376255
(CHEMBL408401)Show InChI InChI=1S/C23H25N3O/c1-26(20-8-3-2-4-9-20)21-13-11-17(12-14-21)23(27)25-19-15-18-7-5-6-10-22(18)24-16-19/h5-7,10-16,20H,2-4,8-9H2,1H3,(H,25,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 8 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson& Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Displacement of [3H]RTX from human TRPV1 receptor expressed in HEK293 cells |
Bioorg Med Chem Lett 18: 2730-4 (2008)
Article DOI: 10.1016/j.bmcl.2008.02.075
BindingDB Entry DOI: 10.7270/Q27H1KF6 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50223339
(1-(2-(4-fluorophenyl)-3-phenylpropyl)-3-(isoquinol...)Show SMILES Fc1ccc(cc1)C(CNC(=O)Nc1cccc2cnccc12)Cc1ccccc1 |w:7.8| Show InChI InChI=1S/C25H22FN3O/c26-22-11-9-19(10-12-22)21(15-18-5-2-1-3-6-18)17-28-25(30)29-24-8-4-7-20-16-27-14-13-23(20)24/h1-14,16,21H,15,17H2,(H2,28,29,30) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 8 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Displacement of [3H]RTX from human TRPV1 expressed in HEK293 cells |
Bioorg Med Chem Lett 17: 6160-3 (2007)
Article DOI: 10.1016/j.bmcl.2007.09.036
BindingDB Entry DOI: 10.7270/Q28G8KFT |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50223334
(1-(1-(4-methoxybenzyl)-6-methoxy-1,2,3,4-tetrahydr...)Show SMILES COc1ccc(CC2C(CCc3cc(OC)ccc23)NC(=O)Nc2cccc3cnccc23)cc1 |w:7.6,8.20| Show InChI InChI=1S/C29H29N3O3/c1-34-22-9-6-19(7-10-22)16-26-24-12-11-23(35-2)17-20(24)8-13-28(26)32-29(33)31-27-5-3-4-21-18-30-15-14-25(21)27/h3-7,9-12,14-15,17-18,26,28H,8,13,16H2,1-2H3,(H2,31,32,33) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 8 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Displacement of [3H]RTX from human TRPV1 expressed in HEK293 cells |
Bioorg Med Chem Lett 17: 6160-3 (2007)
Article DOI: 10.1016/j.bmcl.2007.09.036
BindingDB Entry DOI: 10.7270/Q28G8KFT |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50147082
(1-(3,4-Dichloro-benzyl)-3-isoquinolin-5-yl-urea | ...)Show InChI InChI=1S/C17H13Cl2N3O/c18-14-5-4-11(8-15(14)19)9-21-17(23)22-16-3-1-2-12-10-20-7-6-13(12)16/h1-8,10H,9H2,(H2,21,22,23) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 9 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Antagonistic activity towards human vanilloid receptor subtype 1 expressed in HEK293 cell membrane, as inhibition of agonist-induced intracellular [C... |
Bioorg Med Chem Lett 14: 3053-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.04.038
BindingDB Entry DOI: 10.7270/Q2FB52D6 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50223329
(1-(1-benzyl-6-methoxy-1,2,3,4-tetrahydronaphthalen...)Show SMILES COc1ccc2C(Cc3ccccc3)C(CCc2c1)NC(=O)Nc1cccc2ccc(O)cc12 |w:6.6,14.21| Show InChI InChI=1S/C29H28N2O3/c1-34-23-13-14-24-21(17-23)11-15-28(26(24)16-19-6-3-2-4-7-19)31-29(33)30-27-9-5-8-20-10-12-22(32)18-25(20)27/h2-10,12-14,17-18,26,28,32H,11,15-16H2,1H3,(H2,30,31,33) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Displacement of [3H]RTX from human TRPV1 expressed in HEK293 cells |
Bioorg Med Chem Lett 17: 6160-3 (2007)
Article DOI: 10.1016/j.bmcl.2007.09.036
BindingDB Entry DOI: 10.7270/Q28G8KFT |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50223319
(1-(1-benzyl-6-chloro-1,2,3,4-tetrahydronaphthalen-...)Show SMILES Clc1ccc2C(Cc3ccccc3)C(CCc2c1)NC(=O)Nc1cccc2cnccc12 |w:5.5,13.20| Show InChI InChI=1S/C27H24ClN3O/c28-21-10-11-22-19(16-21)9-12-26(24(22)15-18-5-2-1-3-6-18)31-27(32)30-25-8-4-7-20-17-29-14-13-23(20)25/h1-8,10-11,13-14,16-17,24,26H,9,12,15H2,(H2,30,31,32) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 11 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Displacement of [3H]RTX from human TRPV1 expressed in HEK293 cells |
Bioorg Med Chem Lett 17: 6160-3 (2007)
Article DOI: 10.1016/j.bmcl.2007.09.036
BindingDB Entry DOI: 10.7270/Q28G8KFT |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50147061
(3-(4-tert-Butyl-phenyl)-N-isoquinolin-5-yl-propion...)Show InChI InChI=1S/C22H24N2O/c1-22(2,3)18-10-7-16(8-11-18)9-12-21(25)24-20-6-4-5-17-15-23-14-13-19(17)20/h4-8,10-11,13-15H,9,12H2,1-3H3,(H,24,25) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 11 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Binding affinity towards human vanilloid receptor subtype 1 expressed in HEK293 cell membrane using [3H]-RTX as radioligand. |
Bioorg Med Chem Lett 14: 3053-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.04.038
BindingDB Entry DOI: 10.7270/Q2FB52D6 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50376256
(CHEMBL259017)Show InChI InChI=1S/C25H31N3O/c1-3-4-5-6-7-10-17-28(2)23-15-13-20(14-16-23)25(29)27-22-18-21-11-8-9-12-24(21)26-19-22/h8-9,11-16,18-19H,3-7,10,17H2,1-2H3,(H,27,29) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 15 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson& Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Displacement of [3H]RTX from human TRPV1 receptor expressed in HEK293 cells |
Bioorg Med Chem Lett 18: 2730-4 (2008)
Article DOI: 10.1016/j.bmcl.2008.02.075
BindingDB Entry DOI: 10.7270/Q27H1KF6 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50376268
(CHEMBL405387)Show SMILES CN(CC1CCCCC1)c1ccc(cc1)C(=O)Nc1cnc2ccccc2c1 Show InChI InChI=1S/C24H27N3O/c1-27(17-18-7-3-2-4-8-18)22-13-11-19(12-14-22)24(28)26-21-15-20-9-5-6-10-23(20)25-16-21/h5-6,9-16,18H,2-4,7-8,17H2,1H3,(H,26,28) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 16 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson& Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Displacement of [3H]RTX from human TRPV1 receptor expressed in HEK293 cells |
Bioorg Med Chem Lett 18: 2730-4 (2008)
Article DOI: 10.1016/j.bmcl.2008.02.075
BindingDB Entry DOI: 10.7270/Q27H1KF6 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50223312
(1-(6-fluoro-1-(furan-3-ylmethyl)-1,2,3,4-tetrahydr...)Show SMILES Fc1ccc2C(Cc3ccoc3)C(CCc2c1)NC(=O)Nc1cccc2cnccc12 |w:5.5,12.19| Show InChI InChI=1S/C25H22FN3O2/c26-19-5-6-20-17(13-19)4-7-24(22(20)12-16-9-11-31-15-16)29-25(30)28-23-3-1-2-18-14-27-10-8-21(18)23/h1-3,5-6,8-11,13-15,22,24H,4,7,12H2,(H2,28,29,30) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 16 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Displacement of [3H]RTX from human TRPV1 expressed in HEK293 cells |
Bioorg Med Chem Lett 17: 6160-3 (2007)
Article DOI: 10.1016/j.bmcl.2007.09.036
BindingDB Entry DOI: 10.7270/Q28G8KFT |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50223320
(1-(1-(4-cyanobenzyl)-6-methoxy-1,2,3,4-tetrahydron...)Show SMILES COc1ccc2C(Cc3ccc(cc3)C#N)C(CCc2c1)NC(=O)Nc1cccc2cnccc12 |w:6.6,16.23| Show InChI InChI=1S/C29H26N4O2/c1-35-23-10-11-24-21(16-23)9-12-28(26(24)15-19-5-7-20(17-30)8-6-19)33-29(34)32-27-4-2-3-22-18-31-14-13-25(22)27/h2-8,10-11,13-14,16,18,26,28H,9,12,15H2,1H3,(H2,32,33,34) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 17 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Displacement of [3H]RTX from human TRPV1 expressed in HEK293 cells |
Bioorg Med Chem Lett 17: 6160-3 (2007)
Article DOI: 10.1016/j.bmcl.2007.09.036
BindingDB Entry DOI: 10.7270/Q28G8KFT |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50147068
(1-[2-(3,4-Dichloro-phenyl)-ethyl]-3-isoquinolin-5-...)Show InChI InChI=1S/C18H15Cl2N3O/c19-15-5-4-12(10-16(15)20)6-9-22-18(24)23-17-3-1-2-13-11-21-8-7-14(13)17/h1-5,7-8,10-11H,6,9H2,(H2,22,23,24) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 17 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Binding affinity towards human vanilloid receptor subtype 1 expressed in HEK293 cell membrane using [3H]-RTX as radioligand. |
Bioorg Med Chem Lett 14: 3053-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.04.038
BindingDB Entry DOI: 10.7270/Q2FB52D6 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50147065
(1-(3,4-Dichloro-phenyl)-3-isoquinolin-5-yl-urea | ...)Show InChI InChI=1S/C16H11Cl2N3O/c17-13-5-4-11(8-14(13)18)20-16(22)21-15-3-1-2-10-9-19-7-6-12(10)15/h1-9H,(H2,20,21,22) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| 17 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Binding affinity towards human vanilloid receptor subtype 1 expressed in HEK293 cell membrane using [3H]-RTX as radioligand. |
Bioorg Med Chem Lett 14: 3053-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.04.038
BindingDB Entry DOI: 10.7270/Q2FB52D6 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50147074
(1-Isoquinolin-5-yl-3-(3-trifluoromethyl-phenyl)-ur...)Show InChI InChI=1S/C17H12F3N3O/c18-17(19,20)12-4-2-5-13(9-12)22-16(24)23-15-6-1-3-11-10-21-8-7-14(11)15/h1-10H,(H2,22,23,24) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 19 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Binding affinity towards human vanilloid receptor subtype 1 expressed in HEK293 cell membrane using [3H]-RTX as radioligand. |
Bioorg Med Chem Lett 14: 3053-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.04.038
BindingDB Entry DOI: 10.7270/Q2FB52D6 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50223318
(1-(2-(4-fluorophenyl)-3-(3-(trifluoromethyl)phenyl...)Show SMILES Fc1ccc(cc1)C(CNC(=O)Nc1cccc2cnccc12)Cc1cccc(c1)C(F)(F)F |w:7.25| Show InChI InChI=1S/C26H21F4N3O/c27-22-9-7-18(8-10-22)20(13-17-3-1-5-21(14-17)26(28,29)30)16-32-25(34)33-24-6-2-4-19-15-31-12-11-23(19)24/h1-12,14-15,20H,13,16H2,(H2,32,33,34) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Displacement of [3H]RTX from human TRPV1 expressed in HEK293 cells |
Bioorg Med Chem Lett 17: 6160-3 (2007)
Article DOI: 10.1016/j.bmcl.2007.09.036
BindingDB Entry DOI: 10.7270/Q28G8KFT |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50223317
(1-(1-benzyl-6,7-dimethoxy-1,2,3,4-tetrahydronaphth...)Show SMILES COc1cc2CCC(NC(=O)Nc3cccc4cnccc34)C(Cc3ccccc3)c2cc1OC |w:22.24,7.7| Show InChI InChI=1S/C29H29N3O3/c1-34-27-16-20-11-12-26(24(23(20)17-28(27)35-2)15-19-7-4-3-5-8-19)32-29(33)31-25-10-6-9-21-18-30-14-13-22(21)25/h3-10,13-14,16-18,24,26H,11-12,15H2,1-2H3,(H2,31,32,33) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Displacement of [3H]RTX from human TRPV1 expressed in HEK293 cells |
Bioorg Med Chem Lett 17: 6160-3 (2007)
Article DOI: 10.1016/j.bmcl.2007.09.036
BindingDB Entry DOI: 10.7270/Q28G8KFT |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM20417
(3-isoquinolin-5-yl-1-{2-[4-(trifluoromethyl)phenyl...)Show InChI InChI=1S/C19H16F3N3O/c20-19(21,22)15-6-4-13(5-7-15)8-11-24-18(26)25-17-3-1-2-14-12-23-10-9-16(14)17/h1-7,9-10,12H,8,11H2,(H2,24,25,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 22 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Antagonistic activity towards human vanilloid receptor subtype 1 expressed in HEK293 cell membrane, as inhibition of agonist-induced intracellular [C... |
Bioorg Med Chem Lett 14: 3053-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.04.038
BindingDB Entry DOI: 10.7270/Q2FB52D6 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50223325
(1-(1-(4-(trifluoromethyl)benzyl)-6-fluoro-1,2,3,4-...)Show SMILES Oc1ccc2cccc(NC(=O)NC3CCc4cc(F)ccc4C3Cc3ccc(cc3)C(F)(F)F)c2c1 |w:23.25,13.12| Show InChI InChI=1S/C29H24F4N2O2/c30-21-10-12-23-19(15-21)7-13-27(25(23)14-17-4-8-20(9-5-17)29(31,32)33)35-28(37)34-26-3-1-2-18-6-11-22(36)16-24(18)26/h1-6,8-12,15-16,25,27,36H,7,13-14H2,(H2,34,35,37) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 22 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Displacement of [3H]RTX from human TRPV1 expressed in HEK293 cells |
Bioorg Med Chem Lett 17: 6160-3 (2007)
Article DOI: 10.1016/j.bmcl.2007.09.036
BindingDB Entry DOI: 10.7270/Q28G8KFT |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM20416
(3-isoquinolin-5-yl-1-{[3-(trifluoromethyl)phenyl]m...)Show InChI InChI=1S/C18H14F3N3O/c19-18(20,21)14-5-1-3-12(9-14)10-23-17(25)24-16-6-2-4-13-11-22-8-7-15(13)16/h1-9,11H,10H2,(H2,23,24,25) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 23 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Binding affinity towards human vanilloid receptor subtype 1 expressed in HEK293 cell membrane using [3H]-RTX as radioligand. |
Bioorg Med Chem Lett 14: 3053-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.04.038
BindingDB Entry DOI: 10.7270/Q2FB52D6 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50376272
(CHEMBL407233)Show SMILES CCCCCCCCCN(C)c1ccc(cc1)C(=O)Nc1cnc2ccccc2c1 Show InChI InChI=1S/C26H33N3O/c1-3-4-5-6-7-8-11-18-29(2)24-16-14-21(15-17-24)26(30)28-23-19-22-12-9-10-13-25(22)27-20-23/h9-10,12-17,19-20H,3-8,11,18H2,1-2H3,(H,28,30) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 23 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson& Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Displacement of [3H]RTX from human TRPV1 receptor expressed in HEK293 cells |
Bioorg Med Chem Lett 18: 2730-4 (2008)
Article DOI: 10.1016/j.bmcl.2008.02.075
BindingDB Entry DOI: 10.7270/Q27H1KF6 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50376277
(CHEMBL258917)Show InChI InChI=1S/C20H20N2O/c1-20(2,3)16-10-8-14(9-11-16)19(23)22-17-12-15-6-4-5-7-18(15)21-13-17/h4-13H,1-3H3,(H,22,23) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 24 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson& Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Displacement of [3H]RTX from human TRPV1 receptor expressed in HEK293 cells |
Bioorg Med Chem Lett 18: 2730-4 (2008)
Article DOI: 10.1016/j.bmcl.2008.02.075
BindingDB Entry DOI: 10.7270/Q27H1KF6 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50376273
(CHEMBL261766)Show InChI InChI=1S/C24H29N3O/c1-3-4-5-6-9-16-27(2)22-14-12-19(13-15-22)24(28)26-21-17-20-10-7-8-11-23(20)25-18-21/h7-8,10-15,17-18H,3-6,9,16H2,1-2H3,(H,26,28) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 24 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson& Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Displacement of [3H]RTX from human TRPV1 receptor expressed in HEK293 cells |
Bioorg Med Chem Lett 18: 2730-4 (2008)
Article DOI: 10.1016/j.bmcl.2008.02.075
BindingDB Entry DOI: 10.7270/Q27H1KF6 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50376260
(CHEMBL259601)Show InChI InChI=1S/C21H21NO2/c1-2-3-5-15-8-10-17(11-9-15)21(24)22-20-7-4-6-16-12-13-18(23)14-19(16)20/h4,6-14,23H,2-3,5H2,1H3,(H,22,24) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| 29 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson& Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Displacement of [3H]RTX from human TRPV1 receptor expressed in HEK293 cells |
Bioorg Med Chem Lett 18: 2730-4 (2008)
Article DOI: 10.1016/j.bmcl.2008.02.075
BindingDB Entry DOI: 10.7270/Q27H1KF6 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50147075
(1-(4-Chloro-benzyl)-3-isoquinolin-5-yl-urea | CHEM...)Show InChI InChI=1S/C17H14ClN3O/c18-14-6-4-12(5-7-14)10-20-17(22)21-16-3-1-2-13-11-19-9-8-15(13)16/h1-9,11H,10H2,(H2,20,21,22) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 31 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Binding affinity towards human vanilloid receptor subtype 1 expressed in HEK293 cell membrane using [3H]-RTX as radioligand. |
Bioorg Med Chem Lett 14: 3053-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.04.038
BindingDB Entry DOI: 10.7270/Q2FB52D6 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50376275
(CHEMBL260356)Show InChI InChI=1S/C22H25N3O/c1-3-4-7-14-25(2)20-12-10-17(11-13-20)22(26)24-19-15-18-8-5-6-9-21(18)23-16-19/h5-6,8-13,15-16H,3-4,7,14H2,1-2H3,(H,24,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 38 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson& Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Displacement of [3H]RTX from human TRPV1 receptor expressed in HEK293 cells |
Bioorg Med Chem Lett 18: 2730-4 (2008)
Article DOI: 10.1016/j.bmcl.2008.02.075
BindingDB Entry DOI: 10.7270/Q27H1KF6 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM20418
(3-isoquinolin-5-yl-1-{2-[3-(trifluoromethyl)phenyl...)Show InChI InChI=1S/C19H16F3N3O/c20-19(21,22)15-5-1-3-13(11-15)7-10-24-18(26)25-17-6-2-4-14-12-23-9-8-16(14)17/h1-6,8-9,11-12H,7,10H2,(H2,24,25,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 41 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Binding affinity towards human vanilloid receptor subtype 1 expressed in HEK293 cell membrane using [3H]-RTX as radioligand. |
Bioorg Med Chem Lett 14: 3053-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.04.038
BindingDB Entry DOI: 10.7270/Q2FB52D6 |
More data for this
Ligand-Target Pair | |
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