Found 214 hits with Last Name = 'menezes' and Initial = 'd' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50265746
(CHEMBL526507 | {4-Amino-3-[6-(4-methylpiperazinyl)...)Show SMILES CN1CCN(CC1)c1ccc2nc([nH]c2c1)-c1c(N)c2cc(ccc2[nH]c1=O)C(=O)NCc1ccccc1 Show InChI InChI=1S/C29H29N7O2/c1-35-11-13-36(14-12-35)20-8-10-23-24(16-20)33-27(32-23)25-26(30)21-15-19(7-9-22(21)34-29(25)38)28(37)31-17-18-5-3-2-4-6-18/h2-10,15-16H,11-14,17H2,1H3,(H,31,37)(H,32,33)(H3,30,34,38) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 0.100 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research
Curated by ChEMBL
| Assay Description Inhibition of human recombinant PDGFRbeta |
J Med Chem 52: 278-92 (2009)
Article DOI: 10.1021/jm800790t BindingDB Entry DOI: 10.7270/Q2TD9X7X |
More data for this Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50265774
(4-Amino-3-benzimidazol-2-yl-5-(1-methyl(3-piperidy...)Show SMILES CN1CCCC(C1)Oc1cccc2[nH]c(=O)c(-c3nc4ccccc4[nH]3)c(N)c12 Show InChI InChI=1S/C22H23N5O2/c1-27-11-5-6-13(12-27)29-17-10-4-9-16-18(17)20(23)19(22(28)26-16)21-24-14-7-2-3-8-15(14)25-21/h2-4,7-10,13H,5-6,11-12H2,1H3,(H,24,25)(H3,23,26,28) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 0.100 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research
Curated by ChEMBL
| Assay Description Inhibition of human recombinant PDGFRbeta |
J Med Chem 52: 278-92 (2009)
Article DOI: 10.1021/jm800790t BindingDB Entry DOI: 10.7270/Q2TD9X7X |
More data for this Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50265574
(3-(1H-benzo[d]imidazol-2-yl)-4-(4-ethyl-1-methylpi...)Show SMILES CCC1CCN(C)C(C1)Nc1c(-c2nc3ccccc3[nH]2)c(=O)[nH]c2ccccc12 Show InChI InChI=1S/C24H27N5O/c1-3-15-12-13-29(2)20(14-15)28-22-16-8-4-5-9-17(16)27-24(30)21(22)23-25-18-10-6-7-11-19(18)26-23/h4-11,15,20H,3,12-14H2,1-2H3,(H,25,26)(H2,27,28,30) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research
Curated by ChEMBL
| Assay Description Inhibition of human recombinant PDGFRbeta |
J Med Chem 52: 278-92 (2009)
Article DOI: 10.1021/jm800790t BindingDB Entry DOI: 10.7270/Q2TD9X7X |
More data for this Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50265678
(4-Amino-5-chloro-3-[6-(4-methylpiperazinyl)benzimi...)Show SMILES CN1CCN(CC1)c1ccc2nc([nH]c2c1)-c1c(N)c2c(Cl)cccc2[nH]c1=O Show InChI InChI=1S/C21H21ClN6O/c1-27-7-9-28(10-8-27)12-5-6-14-16(11-12)25-20(24-14)18-19(23)17-13(22)3-2-4-15(17)26-21(18)29/h2-6,11H,7-10H2,1H3,(H,24,25)(H3,23,26,29) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.300 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research
Curated by ChEMBL
| Assay Description Inhibition of human recombinant PDGFRbeta |
J Med Chem 52: 278-92 (2009)
Article DOI: 10.1021/jm800790t BindingDB Entry DOI: 10.7270/Q2TD9X7X |
More data for this Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50265773
(4-Amino-3-benzimidazol-2-yl-5-(4-methylpiperazinyl...)Show SMILES CN1CCN(CC1)c1cccc2[nH]c(=O)c(-c3nc4ccccc4[nH]3)c(N)c12 Show InChI InChI=1S/C21H22N6O/c1-26-9-11-27(12-10-26)16-8-4-7-15-17(16)19(22)18(21(28)25-15)20-23-13-5-2-3-6-14(13)24-20/h2-8H,9-12H2,1H3,(H,23,24)(H3,22,25,28) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.300 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research
Curated by ChEMBL
| Assay Description Inhibition of human recombinant PDGFRbeta |
J Med Chem 52: 278-92 (2009)
Article DOI: 10.1021/jm800790t BindingDB Entry DOI: 10.7270/Q2TD9X7X |
More data for this Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50265750
(4-Amino-7-fluoro-3-[6-(4-methylpiperazinyl)benzimi...)Show SMILES CN1CCN(CC1)c1ccc2nc([nH]c2c1)-c1c(N)c2ccc(F)cc2[nH]c1=O Show InChI InChI=1S/C21H21FN6O/c1-27-6-8-28(9-7-27)13-3-5-15-17(11-13)25-20(24-15)18-19(23)14-4-2-12(22)10-16(14)26-21(18)29/h2-5,10-11H,6-9H2,1H3,(H,24,25)(H3,23,26,29) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research
Curated by ChEMBL
| Assay Description Inhibition of human recombinant PDGFRbeta |
J Med Chem 52: 278-92 (2009)
Article DOI: 10.1021/jm800790t BindingDB Entry DOI: 10.7270/Q2TD9X7X |
More data for this Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50265745
(4-Amino-6-(benzylamino)-3-(6-(4-methylpiperazin-1-...)Show SMILES CN1CCN(CC1)c1ccc2nc([nH]c2c1)-c1c(N)c2cc(NCc3ccccc3)ccc2[nH]c1=O Show InChI InChI=1S/C28H29N7O/c1-34-11-13-35(14-12-34)20-8-10-23-24(16-20)32-27(31-23)25-26(29)21-15-19(7-9-22(21)33-28(25)36)30-17-18-5-3-2-4-6-18/h2-10,15-16,30H,11-14,17H2,1H3,(H,31,32)(H3,29,33,36) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.600 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research
Curated by ChEMBL
| Assay Description Inhibition of human recombinant PDGFRbeta |
J Med Chem 52: 278-92 (2009)
Article DOI: 10.1021/jm800790t BindingDB Entry DOI: 10.7270/Q2TD9X7X |
More data for this Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50265679
(4-Amino-5-methyl-3-[6-(4-methylpiperazinyl)benzimi...)Show SMILES CN1CCN(CC1)c1ccc2nc([nH]c2c1)-c1c(N)c2c(C)cccc2[nH]c1=O Show InChI InChI=1S/C22H24N6O/c1-13-4-3-5-16-18(13)20(23)19(22(29)26-16)21-24-15-7-6-14(12-17(15)25-21)28-10-8-27(2)9-11-28/h3-7,12H,8-11H2,1-2H3,(H,24,25)(H3,23,26,29) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.700 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research
Curated by ChEMBL
| Assay Description Inhibition of human recombinant PDGFRbeta |
J Med Chem 52: 278-92 (2009)
Article DOI: 10.1021/jm800790t BindingDB Entry DOI: 10.7270/Q2TD9X7X |
More data for this Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50265613
(3-(1H-benzo[d]imidazol-2-yl)-4-(piperidin-4-ylmeth...)Show SMILES O=c1[nH]c2ccccc2c(NCC2CCNCC2)c1-c1nc2ccccc2[nH]1 Show InChI InChI=1S/C22H23N5O/c28-22-19(21-25-17-7-3-4-8-18(17)26-21)20(15-5-1-2-6-16(15)27-22)24-13-14-9-11-23-12-10-14/h1-8,14,23H,9-13H2,(H,25,26)(H2,24,27,28) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.900 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research
Curated by ChEMBL
| Assay Description Inhibition of human recombinant PDGFRbeta |
J Med Chem 52: 278-92 (2009)
Article DOI: 10.1021/jm800790t BindingDB Entry DOI: 10.7270/Q2TD9X7X |
More data for this Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50265641
(4-Amino-3-{6-[(4-methylpiperazinyl)carbonyl]benzim...)Show SMILES CN1CCN(CC1)C(=O)c1ccc2nc([nH]c2c1)-c1c(N)c2ccccc2[nH]c1=O Show InChI InChI=1S/C22H22N6O2/c1-27-8-10-28(11-9-27)22(30)13-6-7-16-17(12-13)25-20(24-16)18-19(23)14-4-2-3-5-15(14)26-21(18)29/h2-7,12H,8-11H2,1H3,(H,24,25)(H3,23,26,29) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.900 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research
Curated by ChEMBL
| Assay Description Inhibition of human recombinant PDGFRbeta |
J Med Chem 52: 278-92 (2009)
Article DOI: 10.1021/jm800790t BindingDB Entry DOI: 10.7270/Q2TD9X7X |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50265774
(4-Amino-3-benzimidazol-2-yl-5-(1-methyl(3-piperidy...)Show SMILES CN1CCCC(C1)Oc1cccc2[nH]c(=O)c(-c3nc4ccccc4[nH]3)c(N)c12 Show InChI InChI=1S/C22H23N5O2/c1-27-11-5-6-13(12-27)29-17-10-4-9-16-18(17)20(23)19(22(28)26-16)21-24-14-7-2-3-8-15(14)25-21/h2-4,7-10,13H,5-6,11-12H2,1H3,(H,24,25)(H3,23,26,28) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research
Curated by ChEMBL
| Assay Description Inhibition of human recombinant FGFR1 |
J Med Chem 52: 278-92 (2009)
Article DOI: 10.1021/jm800790t BindingDB Entry DOI: 10.7270/Q2TD9X7X |
More data for this Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50265676
(CHEMBL495962 | N-(2-(4-Amino-2-oxo-1,2-dihydroquin...)Show SMILES CN(C)CC(=O)N(C)c1ccc2nc([nH]c2c1)-c1c(N)c2ccccc2[nH]c1=O Show InChI InChI=1S/C21H22N6O2/c1-26(2)11-17(28)27(3)12-8-9-15-16(10-12)24-20(23-15)18-19(22)13-6-4-5-7-14(13)25-21(18)29/h4-10H,11H2,1-3H3,(H,23,24)(H3,22,25,29) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research
Curated by ChEMBL
| Assay Description Inhibition of human recombinant PDGFRbeta |
J Med Chem 52: 278-92 (2009)
Article DOI: 10.1021/jm800790t BindingDB Entry DOI: 10.7270/Q2TD9X7X |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50265773
(4-Amino-3-benzimidazol-2-yl-5-(4-methylpiperazinyl...)Show SMILES CN1CCN(CC1)c1cccc2[nH]c(=O)c(-c3nc4ccccc4[nH]3)c(N)c12 Show InChI InChI=1S/C21H22N6O/c1-26-9-11-27(12-10-26)16-8-4-7-15-17(16)19(22)18(21(28)25-15)20-23-13-5-2-3-6-14(13)24-20/h2-8H,9-12H2,1H3,(H,23,24)(H3,22,25,28) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research
Curated by ChEMBL
| Assay Description Inhibition of human recombinant FGFR1 |
J Med Chem 52: 278-92 (2009)
Article DOI: 10.1021/jm800790t BindingDB Entry DOI: 10.7270/Q2TD9X7X |
More data for this Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50265738
(4-Amino-6-fluoro-3-[6-(4-methylpiperazinyl)benzimi...)Show SMILES CN1CCN(CC1)c1ccc2nc([nH]c2c1)-c1c(N)c2cc(F)ccc2[nH]c1=O Show InChI InChI=1S/C21H21FN6O/c1-27-6-8-28(9-7-27)13-3-5-16-17(11-13)25-20(24-16)18-19(23)14-10-12(22)2-4-15(14)26-21(18)29/h2-5,10-11H,6-9H2,1H3,(H,24,25)(H3,23,26,29) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research
Curated by ChEMBL
| Assay Description Inhibition of human recombinant PDGFRbeta |
J Med Chem 52: 278-92 (2009)
Article DOI: 10.1021/jm800790t BindingDB Entry DOI: 10.7270/Q2TD9X7X |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50439721
(CHEMBL2418953)Show SMILES CC(=O)Nc1cn2nc(ccc2n1)-c1cnc(N)c(c1)C(F)(F)F Show InChI InChI=1S/C14H11F3N6O/c1-7(24)20-11-6-23-12(21-11)3-2-10(22-23)8-4-9(14(15,16)17)13(18)19-5-8/h2-6H,1H3,(H2,18,19)(H,20,24) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description Inhibition of PI3Kalpha (unknown origin) using 1 alpha-phosphatidylinositol as substrate assessed as ATP depletion after 5 mins by KinaseGlo assay |
Bioorg Med Chem Lett 26: 742-6 (2016)
Article DOI: 10.1016/j.bmcl.2016.01.003 BindingDB Entry DOI: 10.7270/Q2XP76SB |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50140266
(CHEMBL3753366)Show InChI InChI=1S/C16H18N6O2/c1-9(2)24-16-15(17)18-6-12(20-16)11-4-5-14-21-13(19-10(3)23)8-22(14)7-11/h4-9H,1-3H3,(H2,17,18)(H,19,23) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description Inhibition of PI3Kalpha (unknown origin) using 1 alpha-phosphatidylinositol as substrate assessed as ATP depletion after 5 mins by KinaseGlo assay |
Bioorg Med Chem Lett 26: 742-6 (2016)
Article DOI: 10.1016/j.bmcl.2016.01.003 BindingDB Entry DOI: 10.7270/Q2XP76SB |
More data for this Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50181320
(4-Amino-3-[6-(4-methylpiperazinyl)benzimidazol-2-y...)Show SMILES CN1CCN(CC1)c1ccc2nc([nH]c2c1)-c1c(N)c2ccccc2[nH]c1=O Show InChI InChI=1S/C21H22N6O/c1-26-8-10-27(11-9-26)13-6-7-16-17(12-13)24-20(23-16)18-19(22)14-4-2-3-5-15(14)25-21(18)28/h2-7,12H,8-11H2,1H3,(H,23,24)(H3,22,25,28) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research
Curated by ChEMBL
| Assay Description Inhibition of human recombinant PDGFRbeta |
J Med Chem 52: 278-92 (2009)
Article DOI: 10.1021/jm800790t BindingDB Entry DOI: 10.7270/Q2TD9X7X |
More data for this Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50265675
(4-Amino-3-(6-((4-methylpiperazin-1-yl)methyl)-1H-b...)Show SMILES CN1CCN(Cc2ccc3nc([nH]c3c2)-c2c(N)c3ccccc3[nH]c2=O)CC1 Show InChI InChI=1S/C22H24N6O/c1-27-8-10-28(11-9-27)13-14-6-7-17-18(12-14)25-21(24-17)19-20(23)15-4-2-3-5-16(15)26-22(19)29/h2-7,12H,8-11,13H2,1H3,(H,24,25)(H3,23,26,29) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research
Curated by ChEMBL
| Assay Description Inhibition of human recombinant PDGFRbeta |
J Med Chem 52: 278-92 (2009)
Article DOI: 10.1021/jm800790t BindingDB Entry DOI: 10.7270/Q2TD9X7X |
More data for this Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50265737
(4-Amino-5-(methylamino)-3-(6-(4-methylpiperazin-1-...)Show SMILES CNc1cccc2[nH]c(=O)c(-c3nc4ccc(cc4[nH]3)N3CCN(C)CC3)c(N)c12 Show InChI InChI=1S/C22H25N7O/c1-24-15-4-3-5-16-18(15)20(23)19(22(30)27-16)21-25-14-7-6-13(12-17(14)26-21)29-10-8-28(2)9-11-29/h3-7,12,24H,8-11H2,1-2H3,(H,25,26)(H3,23,27,30) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research
Curated by ChEMBL
| Assay Description Inhibition of human recombinant PDGFRbeta |
J Med Chem 52: 278-92 (2009)
Article DOI: 10.1021/jm800790t BindingDB Entry DOI: 10.7270/Q2TD9X7X |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50265678
(4-Amino-5-chloro-3-[6-(4-methylpiperazinyl)benzimi...)Show SMILES CN1CCN(CC1)c1ccc2nc([nH]c2c1)-c1c(N)c2c(Cl)cccc2[nH]c1=O Show InChI InChI=1S/C21H21ClN6O/c1-27-7-9-28(10-8-27)12-5-6-14-16(11-12)25-20(24-14)18-19(23)17-13(22)3-2-4-15(17)26-21(18)29/h2-6,11H,7-10H2,1H3,(H,24,25)(H3,23,26,29) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research
Curated by ChEMBL
| Assay Description Inhibition of human recombinant FGFR1 |
J Med Chem 52: 278-92 (2009)
Article DOI: 10.1021/jm800790t BindingDB Entry DOI: 10.7270/Q2TD9X7X |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50380371
(CHEMBL2017970)Show SMILES Nc1ncc(-c2cc(Nc3cnc4ccccc4c3)nc(n2)N2CCOCC2)c(n1)C(F)(F)F Show InChI InChI=1S/C22H19F3N8O/c23-22(24,25)19-15(12-28-20(26)32-19)17-10-18(31-21(30-17)33-5-7-34-8-6-33)29-14-9-13-3-1-2-4-16(13)27-11-14/h1-4,9-12H,5-8H2,(H2,26,28,32)(H,29,30,31) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.20 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of PI3Kalpha using 1-alpha-phosphotidylinositol as substrate by ATP depletion assay |
ACS Med Chem Lett 2: 774-779 (2011)
Article DOI: 10.1021/ml200156t BindingDB Entry DOI: 10.7270/Q2N29XXW |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50380366
(CHEMBL2017965)Show SMILES Nc1cc(Cl)c(cn1)-c1cc(Nc2cnc3ccccc3c2)nc(n1)N1CCOCC1 Show InChI InChI=1S/C22H20ClN7O/c23-17-10-20(24)26-13-16(17)19-11-21(29-22(28-19)30-5-7-31-8-6-30)27-15-9-14-3-1-2-4-18(14)25-12-15/h1-4,9-13H,5-8H2,(H2,24,26)(H,27,28,29) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.40 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of PI3Kalpha using 1-alpha-phosphotidylinositol as substrate by ATP depletion assay |
ACS Med Chem Lett 2: 774-779 (2011)
Article DOI: 10.1021/ml200156t BindingDB Entry DOI: 10.7270/Q2N29XXW |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50380369
(CHEMBL2017968)Show SMILES Nc1ncc(c(N)n1)-c1cc(Nc2cnc3ccccc3c2)nc(n1)N1CCOCC1 Show InChI InChI=1S/C21H21N9O/c22-19-15(12-25-20(23)29-19)17-10-18(28-21(27-17)30-5-7-31-8-6-30)26-14-9-13-3-1-2-4-16(13)24-11-14/h1-4,9-12H,5-8H2,(H,26,27,28)(H4,22,23,25,29) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.60 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of PI3Kalpha using 1-alpha-phosphotidylinositol as substrate by ATP depletion assay |
ACS Med Chem Lett 2: 774-779 (2011)
Article DOI: 10.1021/ml200156t BindingDB Entry DOI: 10.7270/Q2N29XXW |
More data for this Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50265753
(4-Amino-6,7-difluoro-3-(6-(4-methylpiperazin-1-yl)...)Show SMILES CN1CCN(CC1)c1ccc2nc([nH]c2c1)-c1c(N)c2cc(F)c(F)cc2[nH]c1=O Show InChI InChI=1S/C21H20F2N6O/c1-28-4-6-29(7-5-28)11-2-3-15-17(8-11)26-20(25-15)18-19(24)12-9-13(22)14(23)10-16(12)27-21(18)30/h2-3,8-10H,4-7H2,1H3,(H,25,26)(H3,24,27,30) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research
Curated by ChEMBL
| Assay Description Inhibition of human recombinant PDGFRbeta |
J Med Chem 52: 278-92 (2009)
Article DOI: 10.1021/jm800790t BindingDB Entry DOI: 10.7270/Q2TD9X7X |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 3
(Homo sapiens (Human)) | BDBM25118
((3Z)-4-amino-5-fluoro-3-[5-(4-methylpiperazino)-1,...)Show SMILES CN1CCN(CC1)c1ccc2nc([nH]c2c1)-c1c(N)c2c(F)cccc2[nH]c1=O Show InChI InChI=1S/C21H21FN6O/c1-27-7-9-28(10-8-27)12-5-6-14-16(11-12)25-20(24-14)18-19(23)17-13(22)3-2-4-15(17)26-21(18)29/h2-6,11H,7-10H2,1H3,(H,24,25)(H3,23,26,29) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research
Curated by ChEMBL
| Assay Description Inhibition of VEGFR3 |
J Med Chem 52: 278-92 (2009)
Article DOI: 10.1021/jm800790t BindingDB Entry DOI: 10.7270/Q2TD9X7X |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50140267
(CHEMBL3752019)Show SMILES CC(=O)Nc1cn2cc(ccc2n1)-c1cnc(N)c(OCC(F)(F)F)n1 Show InChI InChI=1S/C15H13F3N6O2/c1-8(25)21-11-6-24-5-9(2-3-12(24)23-11)10-4-20-13(19)14(22-10)26-7-15(16,17)18/h2-6H,7H2,1H3,(H2,19,20)(H,21,25) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description Inhibition of PI3Kalpha (unknown origin) using 1 alpha-phosphatidylinositol as substrate assessed as ATP depletion after 5 mins by KinaseGlo assay |
Bioorg Med Chem Lett 26: 742-6 (2016)
Article DOI: 10.1016/j.bmcl.2016.01.003 BindingDB Entry DOI: 10.7270/Q2XP76SB |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50140269
(CHEMBL3752653)Show InChI InChI=1S/C15H16N6O2/c1-3-23-15-14(16)17-6-11(19-15)10-4-5-13-20-12(18-9(2)22)8-21(13)7-10/h4-8H,3H2,1-2H3,(H2,16,17)(H,18,22) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description Inhibition of PI3Kalpha (unknown origin) using 1 alpha-phosphatidylinositol as substrate assessed as ATP depletion after 5 mins by KinaseGlo assay |
Bioorg Med Chem Lett 26: 742-6 (2016)
Article DOI: 10.1016/j.bmcl.2016.01.003 BindingDB Entry DOI: 10.7270/Q2XP76SB |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50140270
(CHEMBL3752503)Show InChI InChI=1S/C14H14N6O2/c1-8(21)17-11-7-20-6-9(3-4-12(20)19-11)10-5-16-13(15)14(18-10)22-2/h3-7H,1-2H3,(H2,15,16)(H,17,21) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description Inhibition of PI3Kalpha (unknown origin) using 1 alpha-phosphatidylinositol as substrate assessed as ATP depletion after 5 mins by KinaseGlo assay |
Bioorg Med Chem Lett 26: 742-6 (2016)
Article DOI: 10.1016/j.bmcl.2016.01.003 BindingDB Entry DOI: 10.7270/Q2XP76SB |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50140265
(CHEMBL3753450)Show SMILES CC(Oc1nc(cnc1N)-c1ccc2nc(NC(C)=O)cn2c1)C(F)(F)F Show InChI InChI=1S/C16H15F3N6O2/c1-8(16(17,18)19)27-15-14(20)21-5-11(23-15)10-3-4-13-24-12(22-9(2)26)7-25(13)6-10/h3-8H,1-2H3,(H2,20,21)(H,22,26) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid PDB UniChem
Similars
| PDB Article PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description Inhibition of PI3Kalpha (unknown origin) using 1 alpha-phosphatidylinositol as substrate assessed as ATP depletion after 5 mins by KinaseGlo assay |
Bioorg Med Chem Lett 26: 742-6 (2016)
Article DOI: 10.1016/j.bmcl.2016.01.003 BindingDB Entry DOI: 10.7270/Q2XP76SB |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Receptor-type tyrosine-protein kinase FLT3
(Homo sapiens (Human)) | BDBM25118
((3Z)-4-amino-5-fluoro-3-[5-(4-methylpiperazino)-1,...)Show SMILES CN1CCN(CC1)c1ccc2nc([nH]c2c1)-c1c(N)c2c(F)cccc2[nH]c1=O Show InChI InChI=1S/C21H21FN6O/c1-27-7-9-28(10-8-27)12-5-6-14-16(11-12)25-20(24-14)18-19(23)17-13(22)3-2-4-15(17)26-21(18)29/h2-6,11H,7-10H2,1H3,(H,24,25)(H3,23,26,29) | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research
Curated by ChEMBL
| Assay Description Inhibition of FLT3 |
J Med Chem 52: 278-92 (2009)
Article DOI: 10.1021/jm800790t BindingDB Entry DOI: 10.7270/Q2TD9X7X |
More data for this Ligand-Target Pair | |
Macrophage colony-stimulating factor 1 receptor
(Homo sapiens (Human)) | BDBM25118
((3Z)-4-amino-5-fluoro-3-[5-(4-methylpiperazino)-1,...)Show SMILES CN1CCN(CC1)c1ccc2nc([nH]c2c1)-c1c(N)c2c(F)cccc2[nH]c1=O Show InChI InChI=1S/C21H21FN6O/c1-27-7-9-28(10-8-27)12-5-6-14-16(11-12)25-20(24-14)18-19(23)17-13(22)3-2-4-15(17)26-21(18)29/h2-6,11H,7-10H2,1H3,(H,24,25)(H3,23,26,29) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
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CHEMBL MCE PC cid PC sid UniChem
Patents
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| Article PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research
Curated by ChEMBL
| Assay Description Inhibition of CSF1R |
J Med Chem 52: 278-92 (2009)
Article DOI: 10.1021/jm800790t BindingDB Entry DOI: 10.7270/Q2TD9X7X |
More data for this Ligand-Target Pair | |
Mast/stem cell growth factor receptor Kit
(Homo sapiens (Human)) | BDBM25118
((3Z)-4-amino-5-fluoro-3-[5-(4-methylpiperazino)-1,...)Show SMILES CN1CCN(CC1)c1ccc2nc([nH]c2c1)-c1c(N)c2c(F)cccc2[nH]c1=O Show InChI InChI=1S/C21H21FN6O/c1-27-7-9-28(10-8-27)12-5-6-14-16(11-12)25-20(24-14)18-19(23)17-13(22)3-2-4-15(17)26-21(18)29/h2-6,11H,7-10H2,1H3,(H,24,25)(H3,23,26,29) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
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CHEMBL MCE PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research
Curated by ChEMBL
| Assay Description Inhibition of c-Kit |
J Med Chem 52: 278-92 (2009)
Article DOI: 10.1021/jm800790t BindingDB Entry DOI: 10.7270/Q2TD9X7X |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 3
(Homo sapiens (Human)) | BDBM25118
((3Z)-4-amino-5-fluoro-3-[5-(4-methylpiperazino)-1,...)Show SMILES CN1CCN(CC1)c1ccc2nc([nH]c2c1)-c1c(N)c2c(F)cccc2[nH]c1=O Show InChI InChI=1S/C21H21FN6O/c1-27-7-9-28(10-8-27)12-5-6-14-16(11-12)25-20(24-14)18-19(23)17-13(22)3-2-4-15(17)26-21(18)29/h2-6,11H,7-10H2,1H3,(H,24,25)(H3,23,26,29) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research
Curated by ChEMBL
| Assay Description Inhibition of FGFR3 |
J Med Chem 52: 278-92 (2009)
Article DOI: 10.1021/jm800790t BindingDB Entry DOI: 10.7270/Q2TD9X7X |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 1
(Homo sapiens (Human)) | BDBM25118
((3Z)-4-amino-5-fluoro-3-[5-(4-methylpiperazino)-1,...)Show SMILES CN1CCN(CC1)c1ccc2nc([nH]c2c1)-c1c(N)c2c(F)cccc2[nH]c1=O Show InChI InChI=1S/C21H21FN6O/c1-27-7-9-28(10-8-27)12-5-6-14-16(11-12)25-20(24-14)18-19(23)17-13(22)3-2-4-15(17)26-21(18)29/h2-6,11H,7-10H2,1H3,(H,24,25)(H3,23,26,29) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research
Curated by ChEMBL
| Assay Description Inhibition of VEGFR1 |
J Med Chem 52: 278-92 (2009)
Article DOI: 10.1021/jm800790t BindingDB Entry DOI: 10.7270/Q2TD9X7X |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50265750
(4-Amino-7-fluoro-3-[6-(4-methylpiperazinyl)benzimi...)Show SMILES CN1CCN(CC1)c1ccc2nc([nH]c2c1)-c1c(N)c2ccc(F)cc2[nH]c1=O Show InChI InChI=1S/C21H21FN6O/c1-27-6-8-28(9-7-27)13-3-5-15-17(11-13)25-20(24-15)18-19(23)14-4-2-12(22)10-16(14)26-21(18)29/h2-5,10-11H,6-9H2,1H3,(H,24,25)(H3,23,26,29) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research
Curated by ChEMBL
| Assay Description Inhibition of human recombinant FGFR1 |
J Med Chem 52: 278-92 (2009)
Article DOI: 10.1021/jm800790t BindingDB Entry DOI: 10.7270/Q2TD9X7X |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50265679
(4-Amino-5-methyl-3-[6-(4-methylpiperazinyl)benzimi...)Show SMILES CN1CCN(CC1)c1ccc2nc([nH]c2c1)-c1c(N)c2c(C)cccc2[nH]c1=O Show InChI InChI=1S/C22H24N6O/c1-13-4-3-5-16-18(13)20(23)19(22(29)26-16)21-24-15-7-6-14(12-17(15)25-21)28-10-8-27(2)9-11-28/h3-7,12H,8-11H2,1-2H3,(H,24,25)(H3,23,26,29) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research
Curated by ChEMBL
| Assay Description Inhibition of human recombinant FGFR1 |
J Med Chem 52: 278-92 (2009)
Article DOI: 10.1021/jm800790t BindingDB Entry DOI: 10.7270/Q2TD9X7X |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50265676
(CHEMBL495962 | N-(2-(4-Amino-2-oxo-1,2-dihydroquin...)Show SMILES CN(C)CC(=O)N(C)c1ccc2nc([nH]c2c1)-c1c(N)c2ccccc2[nH]c1=O Show InChI InChI=1S/C21H22N6O2/c1-26(2)11-17(28)27(3)12-8-9-15-16(10-12)24-20(23-15)18-19(22)13-6-4-5-7-14(13)25-21(18)29/h4-10H,11H2,1-3H3,(H,23,24)(H3,22,25,29) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research
Curated by ChEMBL
| Assay Description Inhibition of human recombinant FGFR1 |
J Med Chem 52: 278-92 (2009)
Article DOI: 10.1021/jm800790t BindingDB Entry DOI: 10.7270/Q2TD9X7X |
More data for this Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50265639
(3-{5-[(3S)-3-(Dimethylamino)pyrrolidinyl]benzimida...)Show SMILES CN(C)[C@H]1CCN(C1)c1ccc2nc([nH]c2c1)-c1c(N)c2ccccc2[nH]c1=O |r| Show InChI InChI=1S/C22H24N6O/c1-27(2)14-9-10-28(12-14)13-7-8-17-18(11-13)25-21(24-17)19-20(23)15-5-3-4-6-16(15)26-22(19)29/h3-8,11,14H,9-10,12H2,1-2H3,(H,24,25)(H3,23,26,29)/t14-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research
Curated by ChEMBL
| Assay Description Inhibition of human recombinant PDGFRbeta |
J Med Chem 52: 278-92 (2009)
Article DOI: 10.1021/jm800790t BindingDB Entry DOI: 10.7270/Q2TD9X7X |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50439711
(CHEMBL2418954)Show SMILES CC(=O)Nc1cn2cc(ccc2n1)-c1cnc(N)c(c1)C(F)(F)F Show InChI InChI=1S/C15H12F3N5O/c1-8(24)21-12-7-23-6-9(2-3-13(23)22-12)10-4-11(15(16,17)18)14(19)20-5-10/h2-7H,1H3,(H2,19,20)(H,21,24) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid PDB UniChem
Similars
| Article PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description Inhibition of PI3Kalpha (unknown origin) using 1 alpha-phosphatidylinositol as substrate assessed as ATP depletion after 5 mins by KinaseGlo assay |
Bioorg Med Chem Lett 26: 742-6 (2016)
Article DOI: 10.1016/j.bmcl.2016.01.003 BindingDB Entry DOI: 10.7270/Q2XP76SB |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50380367
(CHEMBL2017966)Show SMILES Nc1cc(C#N)c(cn1)-c1cc(Nc2cnc3ccccc3c2)nc(n1)N1CCOCC1 Show InChI InChI=1S/C23H20N8O/c24-12-16-10-21(25)27-14-18(16)20-11-22(30-23(29-20)31-5-7-32-8-6-31)28-17-9-15-3-1-2-4-19(15)26-13-17/h1-4,9-11,13-14H,5-8H2,(H2,25,27)(H,28,29,30) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 4.10 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of PI3Kalpha using 1-alpha-phosphotidylinositol as substrate by ATP depletion assay |
ACS Med Chem Lett 2: 774-779 (2011)
Article DOI: 10.1021/ml200156t BindingDB Entry DOI: 10.7270/Q2N29XXW |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50265774
(4-Amino-3-benzimidazol-2-yl-5-(1-methyl(3-piperidy...)Show SMILES CN1CCCC(C1)Oc1cccc2[nH]c(=O)c(-c3nc4ccccc4[nH]3)c(N)c12 Show InChI InChI=1S/C22H23N5O2/c1-27-11-5-6-13(12-27)29-17-10-4-9-16-18(17)20(23)19(22(28)26-16)21-24-14-7-2-3-8-15(14)25-21/h2-4,7-10,13H,5-6,11-12H2,1H3,(H,24,25)(H3,23,26,28) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research
Curated by ChEMBL
| Assay Description Inhibition of human recombinant VEGFR2 |
J Med Chem 52: 278-92 (2009)
Article DOI: 10.1021/jm800790t BindingDB Entry DOI: 10.7270/Q2TD9X7X |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50140273
(CHEMBL3752760)Show InChI InChI=1S/C14H14N6O2/c1-8(21)17-12-7-20-13(18-12)4-3-10(19-20)9-5-11(22-2)14(15)16-6-9/h3-7H,1-2H3,(H2,15,16)(H,17,21) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
| Article PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description Inhibition of PI3Kalpha (unknown origin) using 1 alpha-phosphatidylinositol as substrate assessed as ATP depletion after 5 mins by KinaseGlo assay |
Bioorg Med Chem Lett 26: 742-6 (2016)
Article DOI: 10.1016/j.bmcl.2016.01.003 BindingDB Entry DOI: 10.7270/Q2XP76SB |
More data for this Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50265771
(4-Amino-5,7-difluoro-3-[6-(4-methylpiperazinyl)ben...)Show SMILES CN1CCN(CC1)c1ccc2nc([nH]c2c1)-c1c(N)c2c(F)cc(F)cc2[nH]c1=O Show InChI InChI=1S/C21H20F2N6O/c1-28-4-6-29(7-5-28)12-2-3-14-15(10-12)26-20(25-14)18-19(24)17-13(23)8-11(22)9-16(17)27-21(18)30/h2-3,8-10H,4-7H2,1H3,(H,25,26)(H3,24,27,30) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research
Curated by ChEMBL
| Assay Description Inhibition of human recombinant PDGFRbeta |
J Med Chem 52: 278-92 (2009)
Article DOI: 10.1021/jm800790t BindingDB Entry DOI: 10.7270/Q2TD9X7X |
More data for this Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM25118
((3Z)-4-amino-5-fluoro-3-[5-(4-methylpiperazino)-1,...)Show SMILES CN1CCN(CC1)c1ccc2nc([nH]c2c1)-c1c(N)c2c(F)cccc2[nH]c1=O Show InChI InChI=1S/C21H21FN6O/c1-27-7-9-28(10-8-27)12-5-6-14-16(11-12)25-20(24-14)18-19(23)17-13(22)3-2-4-15(17)26-21(18)29/h2-6,11H,7-10H2,1H3,(H,24,25)(H3,23,26,29) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research
Curated by ChEMBL
| Assay Description Inhibition of human recombinant PDGFRbeta |
J Med Chem 52: 278-92 (2009)
Article DOI: 10.1021/jm800790t BindingDB Entry DOI: 10.7270/Q2TD9X7X |
More data for this Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50265640
(4-Amino-3-[5-(2-morpholin-4-ylethoxy)-benzimidazol...)Show SMILES Nc1c(-c2nc3ccc(OCCN4CCOCC4)cc3[nH]2)c(=O)[nH]c2ccccc12 Show InChI InChI=1S/C22H23N5O3/c23-20-15-3-1-2-4-16(15)26-22(28)19(20)21-24-17-6-5-14(13-18(17)25-21)30-12-9-27-7-10-29-11-8-27/h1-6,13H,7-12H2,(H,24,25)(H3,23,26,28) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research
Curated by ChEMBL
| Assay Description Inhibition of human recombinant PDGFRbeta |
J Med Chem 52: 278-92 (2009)
Article DOI: 10.1021/jm800790t BindingDB Entry DOI: 10.7270/Q2TD9X7X |
More data for this Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50265638
(4-Amino-3-[6-(4-methyl(1,4-diazaperhydroepinyl))be...)Show SMILES CN1CCCN(CC1)c1ccc2nc([nH]c2c1)-c1c(N)c2ccccc2[nH]c1=O Show InChI InChI=1S/C22H24N6O/c1-27-9-4-10-28(12-11-27)14-7-8-17-18(13-14)25-21(24-17)19-20(23)15-5-2-3-6-16(15)26-22(19)29/h2-3,5-8,13H,4,9-12H2,1H3,(H,24,25)(H3,23,26,29) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research
Curated by ChEMBL
| Assay Description Inhibition of human recombinant PDGFRbeta |
J Med Chem 52: 278-92 (2009)
Article DOI: 10.1021/jm800790t BindingDB Entry DOI: 10.7270/Q2TD9X7X |
More data for this Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50181311
(4-Amino-3-(6-morpholin-4-ylbenzimidazol-2-yl)hydro...)Show SMILES Nc1c(-c2nc3ccc(cc3[nH]2)N2CCOCC2)c(=O)[nH]c2ccccc12 Show InChI InChI=1S/C20H19N5O2/c21-18-13-3-1-2-4-14(13)24-20(26)17(18)19-22-15-6-5-12(11-16(15)23-19)25-7-9-27-10-8-25/h1-6,11H,7-10H2,(H,22,23)(H3,21,24,26) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research
Curated by ChEMBL
| Assay Description Inhibition of human recombinant PDGFRbeta |
J Med Chem 52: 278-92 (2009)
Article DOI: 10.1021/jm800790t BindingDB Entry DOI: 10.7270/Q2TD9X7X |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50140271
(CHEMBL3751961)Show InChI InChI=1S/C16H18N6O3/c1-10(23)19-14-9-22-15(20-14)4-3-12(21-22)11-7-13(16(17)18-8-11)25-6-5-24-2/h3-4,7-9H,5-6H2,1-2H3,(H2,17,18)(H,19,23) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description Inhibition of PI3Kalpha (unknown origin) using 1 alpha-phosphatidylinositol as substrate assessed as ATP depletion after 5 mins by KinaseGlo assay |
Bioorg Med Chem Lett 26: 742-6 (2016)
Article DOI: 10.1016/j.bmcl.2016.01.003 BindingDB Entry DOI: 10.7270/Q2XP76SB |
More data for this Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50265740
(4,6-Diamino-3-(6-(4-methylpiperazin-1-yl)-1H-benzo...)Show SMILES CN1CCN(CC1)c1ccc2nc([nH]c2c1)-c1c(N)c2cc(N)ccc2[nH]c1=O Show InChI InChI=1S/C21H23N7O/c1-27-6-8-28(9-7-27)13-3-5-16-17(11-13)25-20(24-16)18-19(23)14-10-12(22)2-4-15(14)26-21(18)29/h2-5,10-11H,6-9,22H2,1H3,(H,24,25)(H3,23,26,29) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research
Curated by ChEMBL
| Assay Description Inhibition of human recombinant PDGFRbeta |
J Med Chem 52: 278-92 (2009)
Article DOI: 10.1021/jm800790t BindingDB Entry DOI: 10.7270/Q2TD9X7X |
More data for this Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50265743
(4-Amino-6-(dimethylamino)-3-[6-(4-methylpiperaziny...)Show SMILES CN(C)c1ccc2[nH]c(=O)c(-c3nc4ccc(cc4[nH]3)N3CCN(C)CC3)c(N)c2c1 Show InChI InChI=1S/C23H27N7O/c1-28(2)14-4-6-17-16(12-14)21(24)20(23(31)27-17)22-25-18-7-5-15(13-19(18)26-22)30-10-8-29(3)9-11-30/h4-7,12-13H,8-11H2,1-3H3,(H,25,26)(H3,24,27,31) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research
Curated by ChEMBL
| Assay Description Inhibition of human recombinant PDGFRbeta |
J Med Chem 52: 278-92 (2009)
Article DOI: 10.1021/jm800790t BindingDB Entry DOI: 10.7270/Q2TD9X7X |
More data for this Ligand-Target Pair | |