Found 275 hits with Last Name = 'miller' and Initial = 'dk' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Nicotinic acetylcholine receptor
(RAT) | BDBM50049757
(()-2-(6-Chloro-pyridin-3-yl)-7-aza-bicyclo[2.2.1]h...)Show InChI InChI=1S/C11H13ClN2/c12-11-4-1-7(6-13-11)9-5-8-2-3-10(9)14-8/h1,4,6,8-10,14H,2-3,5H2 | UniProtKB/TrEMBL
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| Article PubMed
| 0.0800 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kentucky
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 302: 687-95 (2002)
Article DOI: 10.1124/jpet.302.2.687 BindingDB Entry DOI: 10.7270/Q21R6P3D |
More data for this Ligand-Target Pair | |
Nicotinic acetylcholine receptor
(RAT) | BDBM50054820
(Methyllycaconitine | [(1S,4S,5R,6S,8R,9R,13S,16S,1...)Show SMILES CCN1C[C@]2(COC(=O)c3ccccc3-n3c(O)cc(C)c3O)CC[C@H](OC)[C@@]34C5C[C@H]6[C@H](OC)C5[C@](O)(C[C@@H]6OC)[C@](O)([C@@H](OC)C23)C14 |wU:4.4,42.46,36.39,44.48,39.43,wD:28.55,32.34,25.27,31.32,TLB:28:29:32:36.38.39,1:2:47:25.23.24,25:28:42.44:4.2.3,THB:42:48:47:25.23.24,29:28:42.44:4.2.3,2:48:36.35.29:47.44,(3.83,-6.7,;5.61,-4.92,;8.1,-4.92,;7.12,-7.5,;8.22,-6.42,;8.22,-7.94,;7.82,-9.45,;8.61,-10.78,;9.94,-10.01,;8.62,-12.33,;7.29,-13.1,;7.29,-14.64,;8.62,-15.41,;9.95,-14.64,;9.95,-13.1,;11.49,-13.09,;12.9,-13.7,;13.3,-15.19,;13.93,-12.55,;13.14,-11.22,;13.91,-9.88,;11.64,-11.55,;10.86,-10.2,;6.88,-5.65,;6.87,-4.11,;8.21,-3.34,;8.2,-1.8,;6.87,-1.03,;9.54,-4.11,;10.5,-3.18,;10.3,-1.71,;11.64,-1.06,;12.67,-2.15,;14.21,-2.15,;14.96,-3.46,;11.97,-3.45,;12.65,-4.9,;13.98,-5.67,;16.6,-3.1,;16.6,-1.56,;17.69,-.47,;19.02,-1.24,;11.93,-6.28,;12.7,-7.59,;10.46,-6.53,;10.06,-8.01,;11.39,-8.78,;9.55,-5.63,;9.53,-2.57,)| Show InChI InChI=1S/C37H50N2O10/c1-7-38-17-34(18-49-32(42)20-10-8-9-11-23(20)39-26(40)14-19(2)31(39)41)13-12-25(46-4)36-22-15-21-24(45-3)16-35(43,27(22)28(21)47-5)37(44,33(36)38)30(48-6)29(34)36/h8-11,14,21-22,24-25,27-30,33,40-41,43-44H,7,12-13,15-18H2,1-6H3/t21-,22?,24+,25+,27?,28+,29?,30+,33?,34+,35-,36+,37+/m1/s1 | UniProtKB/TrEMBL
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| PC cid PC sid UniChem
Similars
| Article PubMed
| 0.640 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kentucky
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 302: 687-95 (2002)
Article DOI: 10.1124/jpet.302.2.687 BindingDB Entry DOI: 10.7270/Q21R6P3D |
More data for this Ligand-Target Pair | |
Nicotinic acetylcholine receptor
(RAT) | BDBM50107863
((-)-cytisine | (1R,9R)-7,11-diazatricyclo[7.3.1.0~...)Show InChI InChI=1S/C11H14N2O/c14-11-3-1-2-10-9-4-8(5-12-6-9)7-13(10)11/h1-3,8-9,12H,4-7H2 | UniProtKB/TrEMBL
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| 1.10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kentucky
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 302: 687-95 (2002)
Article DOI: 10.1124/jpet.302.2.687 BindingDB Entry DOI: 10.7270/Q21R6P3D |
More data for this Ligand-Target Pair | |
Nicotinic acetylcholine receptor
(RAT) | BDBM50049757
(()-2-(6-Chloro-pyridin-3-yl)-7-aza-bicyclo[2.2.1]h...)Show InChI InChI=1S/C11H13ClN2/c12-11-4-1-7(6-13-11)9-5-8-2-3-10(9)14-8/h1,4,6,8-10,14H,2-3,5H2 | UniProtKB/TrEMBL
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| Article PubMed
| 1.10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kentucky
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 302: 687-95 (2002)
Article DOI: 10.1124/jpet.302.2.687 BindingDB Entry DOI: 10.7270/Q21R6P3D |
More data for this Ligand-Target Pair | |
Nicotinic acetylcholine receptor
(RAT) | BDBM50004108
((+-)-nicotine | (R,S)-nicotine | (RS)-nicotine | 3...)Show InChI InChI=1S/C10H14N2/c1-12-7-3-5-10(12)9-4-2-6-11-8-9/h2,4,6,8,10H,3,5,7H2,1H3 | UniProtKB/TrEMBL
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| 5.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kentucky
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 302: 687-95 (2002)
Article DOI: 10.1124/jpet.302.2.687 BindingDB Entry DOI: 10.7270/Q21R6P3D |
More data for this Ligand-Target Pair | |
Nicotinic acetylcholine receptor
(RAT) | BDBM50049757
(()-2-(6-Chloro-pyridin-3-yl)-7-aza-bicyclo[2.2.1]h...)Show InChI InChI=1S/C11H13ClN2/c12-11-4-1-7(6-13-11)9-5-8-2-3-10(9)14-8/h1,4,6,8-10,14H,2-3,5H2 | UniProtKB/TrEMBL
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| 11 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kentucky
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 302: 687-95 (2002)
Article DOI: 10.1124/jpet.302.2.687 BindingDB Entry DOI: 10.7270/Q21R6P3D |
More data for this Ligand-Target Pair | |
Synaptic vesicular amine transporter
(Rattus norvegicus (Rat)) | BDBM50017701
(3-Isobutyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-...)Show InChI InChI=1S/C19H27NO3/c1-12(2)7-14-11-20-6-5-13-8-18(22-3)19(23-4)9-15(13)16(20)10-17(14)21/h8-9,12,14,16H,5-7,10-11H2,1-4H3 | PDB
UniProtKB/SwissProt
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| 13 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kentucky
Curated by ChEMBL
| Assay Description Displacement of [3H]MTBZ from VMAT2 in rat whole brain vesicles by liquid scintillation spectrophotometry |
Bioorg Med Chem 18: 640-9 (2010)
Article DOI: 10.1016/j.bmc.2009.12.002 BindingDB Entry DOI: 10.7270/Q2XS5WB2 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat)) | BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)Show SMILES Fc1ccc(cc1)C(OCCN1CCN(CCCc2ccccc2)CC1)c1ccc(F)cc1 Show InChI InChI=1S/C28H32F2N2O/c29-26-12-8-24(9-13-26)28(25-10-14-27(30)15-11-25)33-22-21-32-19-17-31(18-20-32)16-4-7-23-5-2-1-3-6-23/h1-3,5-6,8-15,28H,4,7,16-22H2 | Reactome pathway KEGG
UniProtKB/SwissProt
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| Article PubMed
| 18 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kentucky
Curated by ChEMBL
| Assay Description Inhibition of [3H]DA uptake at DAT in rat brain striatal synaptosomes by liquid scintillation spectrophotometry |
Bioorg Med Chem 18: 640-9 (2010)
Article DOI: 10.1016/j.bmc.2009.12.002 BindingDB Entry DOI: 10.7270/Q2XS5WB2 |
More data for this Ligand-Target Pair | |
Sodium-dependent serotonin transporter
(Rattus norvegicus (rat)) | BDBM30130
(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)Show InChI InChI=1S/C17H18F3NO/c1-21-12-11-16(13-5-3-2-4-6-13)22-15-9-7-14(8-10-15)17(18,19)20/h2-10,16,21H,11-12H2,1H3 | PDB
KEGG
UniProtKB/SwissProt
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| 41 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kentucky
Curated by ChEMBL
| Assay Description Inhibition of [3H]5HT uptake at SERT in rat brain hippocampal synaptosomes by liquid scintillation spectrophotometry |
Bioorg Med Chem 18: 640-9 (2010)
Article DOI: 10.1016/j.bmc.2009.12.002 BindingDB Entry DOI: 10.7270/Q2XS5WB2 |
More data for this Ligand-Target Pair | |
Sodium-dependent dopamine transporter
(Homo sapiens (Human)) | BDBM50171941
((2R,6S)-1-Methyl-2,6-bis-((E)-styryl)-piperidine |...)Show SMILES CN1[C@@H](CCC[C@@H]1\C=C\c1ccccc1)\C=C\c1ccccc1 Show InChI InChI=1S/C22H25N/c1-23-21(17-15-19-9-4-2-5-10-19)13-8-14-22(23)18-16-20-11-6-3-7-12-20/h2-7,9-12,15-18,21-22H,8,13-14H2,1H3/b17-15+,18-16+/t21-,22+ | NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 43 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kentucky
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 310: 1035-45 (2004)
Article DOI: 10.1124/jpet.104.068098 BindingDB Entry DOI: 10.7270/Q2WH2NJN |
More data for this Ligand-Target Pair | |
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat)) | BDBM50192903
(8R-hydroxylobel-9-ene | CHEMBL425617)Show SMILES CN1[C@@H](C[C@@H](O)c2ccccc2)CCC[C@H]1\C=C\c1ccccc1 Show InChI InChI=1S/C22H27NO/c1-23-20(16-15-18-9-4-2-5-10-18)13-8-14-21(23)17-22(24)19-11-6-3-7-12-19/h2-7,9-12,15-16,20-22,24H,8,13-14,17H2,1H3/b16-15+/t20-,21+,22+/m0/s1 | Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 44 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kentucky
Curated by ChEMBL
| Assay Description Inhibition of [3H]DA uptake at DAT in rat brain striatal synaptosomes by liquid scintillation spectrophotometry |
Bioorg Med Chem 18: 640-9 (2010)
Article DOI: 10.1016/j.bmc.2009.12.002 BindingDB Entry DOI: 10.7270/Q2XS5WB2 |
More data for this Ligand-Target Pair | |
Nicotinic acetylcholine receptor
(RAT) | BDBM50107863
((-)-cytisine | (1R,9R)-7,11-diazatricyclo[7.3.1.0~...)Show InChI InChI=1S/C11H14N2O/c14-11-3-1-2-10-9-4-8(5-12-6-9)7-13(10)11/h1-3,8-9,12H,4-7H2 | UniProtKB/TrEMBL
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CHEMBL MCE PC cid PC sid UniChem
Similars
| Article PubMed
| 44 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kentucky
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 302: 687-95 (2002)
Article DOI: 10.1124/jpet.302.2.687 BindingDB Entry DOI: 10.7270/Q21R6P3D |
More data for this Ligand-Target Pair | |
Sodium-dependent dopamine transporter
(Homo sapiens (Human)) | BDBM50080827
((2R,6S)-1-Methyl-2,6-diphenethyl-piperidine | (2S,...)Show SMILES CN1[C@@H](CCc2ccccc2)CCC[C@H]1CCc1ccccc1 |r| Show InChI InChI=1S/C22H29N/c1-23-21(17-15-19-9-4-2-5-10-19)13-8-14-22(23)18-16-20-11-6-3-7-12-20/h2-7,9-12,21-22H,8,13-18H2,1H3/t21-,22+ | NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 97 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kentucky
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 310: 1035-45 (2004)
Article DOI: 10.1124/jpet.104.068098 BindingDB Entry DOI: 10.7270/Q2WH2NJN |
More data for this Ligand-Target Pair | |
Nicotinic acetylcholine receptor
(RAT) | BDBM50004108
((+-)-nicotine | (R,S)-nicotine | (RS)-nicotine | 3...)Show InChI InChI=1S/C10H14N2/c1-12-7-3-5-10(12)9-4-2-6-11-8-9/h2,4,6,8,10H,3,5,7H2,1H3 | UniProtKB/TrEMBL
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| Article PubMed
| 154 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kentucky
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 302: 687-95 (2002)
Article DOI: 10.1124/jpet.302.2.687 BindingDB Entry DOI: 10.7270/Q21R6P3D |
More data for this Ligand-Target Pair | |
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human)) | BDBM50171941
((2R,6S)-1-Methyl-2,6-bis-((E)-styryl)-piperidine |...)Show SMILES CN1[C@@H](CCC[C@@H]1\C=C\c1ccccc1)\C=C\c1ccccc1 Show InChI InChI=1S/C22H25N/c1-23-21(17-15-19-9-4-2-5-10-19)13-8-14-22(23)18-16-20-11-6-3-7-12-20/h2-7,9-12,15-18,21-22H,8,13-14H2,1H3/b17-15+,18-16+/t21-,22+ | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 277 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kentucky
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 310: 1035-45 (2004)
Article DOI: 10.1124/jpet.104.068098 BindingDB Entry DOI: 10.7270/Q2WH2NJN |
More data for this Ligand-Target Pair | |
Sodium-dependent dopamine transporter
(Homo sapiens (Human)) | BDBM86207
(CAS_50-36-2 | COCAINE | NSC_446220)Show SMILES COC(=O)C1C2CCC(CC1OC(=O)c1ccccc1)N2C |TLB:2:4:20:7.6,11:10:20:7.6| Show InChI InChI=1S/C17H21NO4/c1-18-12-8-9-13(18)15(17(20)21-2)14(10-12)22-16(19)11-6-4-3-5-7-11/h3-7,12-15H,8-10H2,1-2H3 | NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank GoogleScholar AffyNet
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| Article PubMed
| 469 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kentucky
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 310: 1035-45 (2004)
Article DOI: 10.1124/jpet.104.068098 BindingDB Entry DOI: 10.7270/Q2WH2NJN |
More data for this Ligand-Target Pair | |
Sodium-dependent serotonin transporter
(Homo sapiens (Human)) | BDBM50080827
((2R,6S)-1-Methyl-2,6-diphenethyl-piperidine | (2S,...)Show SMILES CN1[C@@H](CCc2ccccc2)CCC[C@H]1CCc1ccccc1 |r| Show InChI InChI=1S/C22H29N/c1-23-21(17-15-19-9-4-2-5-10-19)13-8-14-22(23)18-16-20-11-6-3-7-12-20/h2-7,9-12,21-22H,8,13-18H2,1H3/t21-,22+ | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 530 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kentucky
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 310: 1035-45 (2004)
Article DOI: 10.1124/jpet.104.068098 BindingDB Entry DOI: 10.7270/Q2WH2NJN |
More data for this Ligand-Target Pair | |
Nicotinic acetylcholine receptor
(RAT) | BDBM50054820
(Methyllycaconitine | [(1S,4S,5R,6S,8R,9R,13S,16S,1...)Show SMILES CCN1C[C@]2(COC(=O)c3ccccc3-n3c(O)cc(C)c3O)CC[C@H](OC)[C@@]34C5C[C@H]6[C@H](OC)C5[C@](O)(C[C@@H]6OC)[C@](O)([C@@H](OC)C23)C14 |wU:4.4,42.46,36.39,44.48,39.43,wD:28.55,32.34,25.27,31.32,TLB:28:29:32:36.38.39,1:2:47:25.23.24,25:28:42.44:4.2.3,THB:42:48:47:25.23.24,29:28:42.44:4.2.3,2:48:36.35.29:47.44,(3.83,-6.7,;5.61,-4.92,;8.1,-4.92,;7.12,-7.5,;8.22,-6.42,;8.22,-7.94,;7.82,-9.45,;8.61,-10.78,;9.94,-10.01,;8.62,-12.33,;7.29,-13.1,;7.29,-14.64,;8.62,-15.41,;9.95,-14.64,;9.95,-13.1,;11.49,-13.09,;12.9,-13.7,;13.3,-15.19,;13.93,-12.55,;13.14,-11.22,;13.91,-9.88,;11.64,-11.55,;10.86,-10.2,;6.88,-5.65,;6.87,-4.11,;8.21,-3.34,;8.2,-1.8,;6.87,-1.03,;9.54,-4.11,;10.5,-3.18,;10.3,-1.71,;11.64,-1.06,;12.67,-2.15,;14.21,-2.15,;14.96,-3.46,;11.97,-3.45,;12.65,-4.9,;13.98,-5.67,;16.6,-3.1,;16.6,-1.56,;17.69,-.47,;19.02,-1.24,;11.93,-6.28,;12.7,-7.59,;10.46,-6.53,;10.06,-8.01,;11.39,-8.78,;9.55,-5.63,;9.53,-2.57,)| Show InChI InChI=1S/C37H50N2O10/c1-7-38-17-34(18-49-32(42)20-10-8-9-11-23(20)39-26(40)14-19(2)31(39)41)13-12-25(46-4)36-22-15-21-24(45-3)16-35(43,27(22)28(21)47-5)37(44,33(36)38)30(48-6)29(34)36/h8-11,14,21-22,24-25,27-30,33,40-41,43-44H,7,12-13,15-18H2,1-6H3/t21-,22?,24+,25+,27?,28+,29?,30+,33?,34+,35-,36+,37+/m1/s1 | UniProtKB/TrEMBL
GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| 567 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kentucky
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 302: 687-95 (2002)
Article DOI: 10.1124/jpet.302.2.687 BindingDB Entry DOI: 10.7270/Q21R6P3D |
More data for this Ligand-Target Pair | |
Synaptic vesicular amine transporter
(Homo sapiens (Human)) | BDBM50171947
((2R,6S)-1-Methyl-2,6-bis-(2-naphthalen-1-yl-ethyl)...)Show SMILES CN1[C@@H](CCc2cccc3ccccc23)CCC[C@H]1CCc1cccc2ccccc12 Show InChI InChI=1S/C30H33N/c1-31-27(21-19-25-13-6-11-23-9-2-4-17-29(23)25)15-8-16-28(31)22-20-26-14-7-12-24-10-3-5-18-30(24)26/h2-7,9-14,17-18,27-28H,8,15-16,19-22H2,1H3/t27-,28+ | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 630 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kentucky
Curated by ChEMBL
| Assay Description Binding affinity to VMAT2 receptor |
Bioorg Med Chem 18: 640-9 (2010)
Article DOI: 10.1016/j.bmc.2009.12.002 BindingDB Entry DOI: 10.7270/Q2XS5WB2 |
More data for this Ligand-Target Pair | |
Sodium-dependent serotonin transporter
(Rattus norvegicus (rat)) | BDBM50192903
(8R-hydroxylobel-9-ene | CHEMBL425617)Show SMILES CN1[C@@H](C[C@@H](O)c2ccccc2)CCC[C@H]1\C=C\c1ccccc1 Show InChI InChI=1S/C22H27NO/c1-23-20(16-15-18-9-4-2-5-10-18)13-8-14-21(23)17-22(24)19-11-6-3-7-12-19/h2-7,9-12,15-16,20-22,24H,8,13-14,17H2,1H3/b16-15+/t20-,21+,22+/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
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| CHEMBL PC cid PC sid UniChem
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| Article PubMed
| 860 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kentucky
Curated by ChEMBL
| Assay Description Inhibition of [3H]5HT uptake at SERT in rat brain hippocampal synaptosomes by liquid scintillation spectrophotometry |
Bioorg Med Chem 18: 640-9 (2010)
Article DOI: 10.1016/j.bmc.2009.12.002 BindingDB Entry DOI: 10.7270/Q2XS5WB2 |
More data for this Ligand-Target Pair | |
Nicotinic acetylcholine receptor
(RAT) | BDBM50004108
((+-)-nicotine | (R,S)-nicotine | (RS)-nicotine | 3...)Show InChI InChI=1S/C10H14N2/c1-12-7-3-5-10(12)9-4-2-6-11-8-9/h2,4,6,8,10H,3,5,7H2,1H3 | UniProtKB/TrEMBL
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| Article PubMed
| 960 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kentucky
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 302: 687-95 (2002)
Article DOI: 10.1124/jpet.302.2.687 BindingDB Entry DOI: 10.7270/Q21R6P3D |
More data for this Ligand-Target Pair | |
Synaptic vesicular amine transporter
(Homo sapiens (Human)) | BDBM50080827
((2R,6S)-1-Methyl-2,6-diphenethyl-piperidine | (2S,...)Show SMILES CN1[C@@H](CCc2ccccc2)CCC[C@H]1CCc1ccccc1 |r| Show InChI InChI=1S/C22H29N/c1-23-21(17-15-19-9-4-2-5-10-19)13-8-14-22(23)18-16-20-11-6-3-7-12-20/h2-7,9-12,21-22H,8,13-18H2,1H3/t21-,22+ | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
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Similars
| Article PubMed
| 970 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kentucky
Curated by ChEMBL
| Assay Description Binding affinity to VMAT2 receptor |
Bioorg Med Chem 18: 640-9 (2010)
Article DOI: 10.1016/j.bmc.2009.12.002 BindingDB Entry DOI: 10.7270/Q2XS5WB2 |
More data for this Ligand-Target Pair | |
Sodium-dependent serotonin transporter
(Rattus norvegicus (rat)) | BDBM50309686
((2S,6S,2R)-2-[6-(2-Isobutyryloxy-2-phenylethyl)-1-...)Show SMILES CC(C)C(=O)O[C@@H](C[C@@H]1CCC[C@H](CC(=O)c2ccccc2)N1C)c1ccccc1 |r| Show InChI InChI=1S/C26H33NO3/c1-19(2)26(29)30-25(21-13-8-5-9-14-21)18-23-16-10-15-22(27(23)3)17-24(28)20-11-6-4-7-12-20/h4-9,11-14,19,22-23,25H,10,15-18H2,1-3H3/t22-,23+,25+/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 1.06E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kentucky
Curated by ChEMBL
| Assay Description Inhibition of [3H]5HT uptake at SERT in rat brain hippocampal synaptosomes by liquid scintillation spectrophotometry |
Bioorg Med Chem 18: 640-9 (2010)
Article DOI: 10.1016/j.bmc.2009.12.002 BindingDB Entry DOI: 10.7270/Q2XS5WB2 |
More data for this Ligand-Target Pair | |
Nicotinic acetylcholine receptor
(RAT) | BDBM50107863
((-)-cytisine | (1R,9R)-7,11-diazatricyclo[7.3.1.0~...)Show InChI InChI=1S/C11H14N2O/c14-11-3-1-2-10-9-4-8(5-12-6-9)7-13(10)11/h1-3,8-9,12H,4-7H2 | UniProtKB/TrEMBL
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CHEMBL MCE PC cid PC sid UniChem
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| Article PubMed
| 1.37E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kentucky
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 302: 687-95 (2002)
Article DOI: 10.1124/jpet.302.2.687 BindingDB Entry DOI: 10.7270/Q21R6P3D |
More data for this Ligand-Target Pair | |
Sodium-dependent serotonin transporter
(Rattus norvegicus (rat)) | BDBM50309685
((2S,6S,2R)-2-[6-(2-Toluyloxy-2-phenylethyl)-1-meth...)Show SMILES CN1[C@H](C[C@H](OC(=O)c2ccc(C)cc2)c2ccccc2)CCC[C@@H]1CC(=O)c1ccccc1 |r| Show InChI InChI=1S/C30H33NO3/c1-22-16-18-25(19-17-22)30(33)34-29(24-12-7-4-8-13-24)21-27-15-9-14-26(31(27)2)20-28(32)23-10-5-3-6-11-23/h3-8,10-13,16-19,26-27,29H,9,14-15,20-21H2,1-2H3/t26-,27+,29+/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 1.51E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kentucky
Curated by ChEMBL
| Assay Description Inhibition of [3H]5HT uptake at SERT in rat brain hippocampal synaptosomes by liquid scintillation spectrophotometry |
Bioorg Med Chem 18: 640-9 (2010)
Article DOI: 10.1016/j.bmc.2009.12.002 BindingDB Entry DOI: 10.7270/Q2XS5WB2 |
More data for this Ligand-Target Pair | |
Synaptic vesicular amine transporter
(Rattus norvegicus (Rat)) | BDBM50309687
((2S,6S,2R)-2-[6-(2-Benzoyloxy-2-phenylethyl)-1-met...)Show SMILES CN1[C@H](C[C@H](OC(=O)c2ccccc2)c2ccccc2)CCC[C@@H]1CC(=O)c1ccccc1 |r| Show InChI InChI=1S/C29H31NO3/c1-30-25(20-27(31)22-12-5-2-6-13-22)18-11-19-26(30)21-28(23-14-7-3-8-15-23)33-29(32)24-16-9-4-10-17-24/h2-10,12-17,25-26,28H,11,18-21H2,1H3/t25-,26+,28+/m1/s1 | PDB
UniProtKB/SwissProt
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| CHEMBL PC cid PC sid UniChem
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| Article PubMed
| 1.53E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kentucky
Curated by ChEMBL
| Assay Description Displacement of [3H]MTBZ from VMAT2 in rat whole brain vesicles by liquid scintillation spectrophotometry |
Bioorg Med Chem 18: 640-9 (2010)
Article DOI: 10.1016/j.bmc.2009.12.002 BindingDB Entry DOI: 10.7270/Q2XS5WB2 |
More data for this Ligand-Target Pair | |
Synaptic vesicular amine transporter
(Rattus norvegicus (Rat)) | BDBM50309685
((2S,6S,2R)-2-[6-(2-Toluyloxy-2-phenylethyl)-1-meth...)Show SMILES CN1[C@H](C[C@H](OC(=O)c2ccc(C)cc2)c2ccccc2)CCC[C@@H]1CC(=O)c1ccccc1 |r| Show InChI InChI=1S/C30H33NO3/c1-22-16-18-25(19-17-22)30(33)34-29(24-12-7-4-8-13-24)21-27-15-9-14-26(31(27)2)20-28(32)23-10-5-3-6-11-23/h3-8,10-13,16-19,26-27,29H,9,14-15,20-21H2,1-2H3/t26-,27+,29+/m1/s1 | PDB
UniProtKB/SwissProt
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| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 1.76E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kentucky
Curated by ChEMBL
| Assay Description Displacement of [3H]MTBZ from VMAT2 in rat whole brain vesicles by liquid scintillation spectrophotometry |
Bioorg Med Chem 18: 640-9 (2010)
Article DOI: 10.1016/j.bmc.2009.12.002 BindingDB Entry DOI: 10.7270/Q2XS5WB2 |
More data for this Ligand-Target Pair | |
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human)) | BDBM50080827
((2R,6S)-1-Methyl-2,6-diphenethyl-piperidine | (2S,...)Show SMILES CN1[C@@H](CCc2ccccc2)CCC[C@H]1CCc1ccccc1 |r| Show InChI InChI=1S/C22H29N/c1-23-21(17-15-19-9-4-2-5-10-19)13-8-14-22(23)18-16-20-11-6-3-7-12-20/h2-7,9-12,21-22H,8,13-18H2,1H3/t21-,22+ | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
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| Article PubMed
| 1.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kentucky
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 310: 1035-45 (2004)
Article DOI: 10.1124/jpet.104.068098 BindingDB Entry DOI: 10.7270/Q2WH2NJN |
More data for this Ligand-Target Pair | |
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human)) | BDBM50047021
(2-(6-(2-hydroxy-2-phenylethyl)-1-methylpiperidin-2...)Show InChI InChI=1S/C22H27NO2/c1-23-19(15-21(24)17-9-4-2-5-10-17)13-8-14-20(23)16-22(25)18-11-6-3-7-12-18/h2-7,9-12,19-21,24H,8,13-16H2,1H3 | Reactome pathway KEGG
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CHEMBL PC cid PC sid PDB UniChem
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| Article PubMed
| 1.87E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kentucky
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 310: 1035-45 (2004)
Article DOI: 10.1124/jpet.104.068098 BindingDB Entry DOI: 10.7270/Q2WH2NJN |
More data for this Ligand-Target Pair | |
Sodium-dependent serotonin transporter
(Homo sapiens (Human)) | BDBM50171941
((2R,6S)-1-Methyl-2,6-bis-((E)-styryl)-piperidine |...)Show SMILES CN1[C@@H](CCC[C@@H]1\C=C\c1ccccc1)\C=C\c1ccccc1 Show InChI InChI=1S/C22H25N/c1-23-21(17-15-19-9-4-2-5-10-19)13-8-14-22(23)18-16-20-11-6-3-7-12-20/h2-7,9-12,15-18,21-22H,8,13-14H2,1H3/b17-15+,18-16+/t21-,22+ | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 1.89E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kentucky
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 310: 1035-45 (2004)
Article DOI: 10.1124/jpet.104.068098 BindingDB Entry DOI: 10.7270/Q2WH2NJN |
More data for this Ligand-Target Pair | |
Synaptic vesicular amine transporter
(Rattus norvegicus (Rat)) | BDBM50309684
((2S,6S,2R)-2-[6-(2-Butylsulfonyloxy-2-phenylethyl)...)Show SMILES CCCCS(=O)(=O)O[C@@H](C[C@@H]1CCC[C@H](CC(=O)c2ccccc2)N1C)c1ccccc1 |r| Show InChI InChI=1S/C26H35NO4S/c1-3-4-18-32(29,30)31-26(22-14-9-6-10-15-22)20-24-17-11-16-23(27(24)2)19-25(28)21-12-7-5-8-13-21/h5-10,12-15,23-24,26H,3-4,11,16-20H2,1-2H3/t23-,24+,26+/m1/s1 | PDB
UniProtKB/SwissProt
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| CHEMBL PC cid PC sid UniChem
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| Article PubMed
| 1.98E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kentucky
Curated by ChEMBL
| Assay Description Displacement of [3HDTBZ from VMAT2 in rat whole brain vesicles by liquid scintillation spectrophotometry |
Bioorg Med Chem 18: 640-9 (2010)
Article DOI: 10.1016/j.bmc.2009.12.002 BindingDB Entry DOI: 10.7270/Q2XS5WB2 |
More data for this Ligand-Target Pair | |
Sodium-dependent serotonin transporter
(Rattus norvegicus (rat)) | BDBM50309688
((2S,6S,2R)-2-[6-(2-Anisoyloxy-2-phenylethyl)-1-met...)Show SMILES COc1ccc(cc1)C(=O)O[C@@H](C[C@@H]1CCC[C@H](CC(=O)c2ccccc2)N1C)c1ccccc1 |r| Show InChI InChI=1S/C30H33NO4/c1-31-25(20-28(32)22-10-5-3-6-11-22)14-9-15-26(31)21-29(23-12-7-4-8-13-23)35-30(33)24-16-18-27(34-2)19-17-24/h3-8,10-13,16-19,25-26,29H,9,14-15,20-21H2,1-2H3/t25-,26+,29+/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 2.04E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kentucky
Curated by ChEMBL
| Assay Description Inhibition of [3H]5HT uptake at SERT in rat brain hippocampal synaptosomes by liquid scintillation spectrophotometry |
Bioorg Med Chem 18: 640-9 (2010)
Article DOI: 10.1016/j.bmc.2009.12.002 BindingDB Entry DOI: 10.7270/Q2XS5WB2 |
More data for this Ligand-Target Pair | |
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat)) | BDBM50309685
((2S,6S,2R)-2-[6-(2-Toluyloxy-2-phenylethyl)-1-meth...)Show SMILES CN1[C@H](C[C@H](OC(=O)c2ccc(C)cc2)c2ccccc2)CCC[C@@H]1CC(=O)c1ccccc1 |r| Show InChI InChI=1S/C30H33NO3/c1-22-16-18-25(19-17-22)30(33)34-29(24-12-7-4-8-13-24)21-27-15-9-14-26(31(27)2)20-28(32)23-10-5-3-6-11-23/h3-8,10-13,16-19,26-27,29H,9,14-15,20-21H2,1-2H3/t26-,27+,29+/m1/s1 | Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 2.06E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kentucky
Curated by ChEMBL
| Assay Description Inhibition of [3H]DA uptake at DAT in rat brain striatal synaptosomes by liquid scintillation spectrophotometry |
Bioorg Med Chem 18: 640-9 (2010)
Article DOI: 10.1016/j.bmc.2009.12.002 BindingDB Entry DOI: 10.7270/Q2XS5WB2 |
More data for this Ligand-Target Pair | |
Sodium-dependent serotonin transporter
(Rattus norvegicus (rat)) | BDBM50309687
((2S,6S,2R)-2-[6-(2-Benzoyloxy-2-phenylethyl)-1-met...)Show SMILES CN1[C@H](C[C@H](OC(=O)c2ccccc2)c2ccccc2)CCC[C@@H]1CC(=O)c1ccccc1 |r| Show InChI InChI=1S/C29H31NO3/c1-30-25(20-27(31)22-12-5-2-6-13-22)18-11-19-26(30)21-28(23-14-7-3-8-15-23)33-29(32)24-16-9-4-10-17-24/h2-10,12-17,25-26,28H,11,18-21H2,1H3/t25-,26+,28+/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
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| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 2.07E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kentucky
Curated by ChEMBL
| Assay Description Inhibition of [3H]5HT uptake at SERT in rat brain hippocampal synaptosomes by liquid scintillation spectrophotometry |
Bioorg Med Chem 18: 640-9 (2010)
Article DOI: 10.1016/j.bmc.2009.12.002 BindingDB Entry DOI: 10.7270/Q2XS5WB2 |
More data for this Ligand-Target Pair | |
Synaptic vesicular amine transporter
(Rattus norvegicus (Rat)) | BDBM50309672
((2S,6S,2R)-2-[6-(2-Isopropylsulfonyloxy-2-phenylet...)Show SMILES CC(C)S(=O)(=O)O[C@@H](C[C@@H]1CCC[C@H](CC(=O)c2ccccc2)N1C)c1ccccc1 |r| Show InChI InChI=1S/C25H33NO4S/c1-19(2)31(28,29)30-25(21-13-8-5-9-14-21)18-23-16-10-15-22(26(23)3)17-24(27)20-11-6-4-7-12-20/h4-9,11-14,19,22-23,25H,10,15-18H2,1-3H3/t22-,23+,25+/m1/s1 | PDB
UniProtKB/SwissProt
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| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 2.09E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kentucky
Curated by ChEMBL
| Assay Description Displacement of [3HDTBZ from VMAT2 in rat whole brain vesicles by liquid scintillation spectrophotometry |
Bioorg Med Chem 18: 640-9 (2010)
Article DOI: 10.1016/j.bmc.2009.12.002 BindingDB Entry DOI: 10.7270/Q2XS5WB2 |
More data for this Ligand-Target Pair | |
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat)) | BDBM50309687
((2S,6S,2R)-2-[6-(2-Benzoyloxy-2-phenylethyl)-1-met...)Show SMILES CN1[C@H](C[C@H](OC(=O)c2ccccc2)c2ccccc2)CCC[C@@H]1CC(=O)c1ccccc1 |r| Show InChI InChI=1S/C29H31NO3/c1-30-25(20-27(31)22-12-5-2-6-13-22)18-11-19-26(30)21-28(23-14-7-3-8-15-23)33-29(32)24-16-9-4-10-17-24/h2-10,12-17,25-26,28H,11,18-21H2,1H3/t25-,26+,28+/m1/s1 | Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 2.31E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kentucky
Curated by ChEMBL
| Assay Description Inhibition of [3H]DA uptake at DAT in rat brain striatal synaptosomes by liquid scintillation spectrophotometry |
Bioorg Med Chem 18: 640-9 (2010)
Article DOI: 10.1016/j.bmc.2009.12.002 BindingDB Entry DOI: 10.7270/Q2XS5WB2 |
More data for this Ligand-Target Pair | |
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat)) | BDBM50309686
((2S,6S,2R)-2-[6-(2-Isobutyryloxy-2-phenylethyl)-1-...)Show SMILES CC(C)C(=O)O[C@@H](C[C@@H]1CCC[C@H](CC(=O)c2ccccc2)N1C)c1ccccc1 |r| Show InChI InChI=1S/C26H33NO3/c1-19(2)26(29)30-25(21-13-8-5-9-14-21)18-23-16-10-15-22(27(23)3)17-24(28)20-11-6-4-7-12-20/h4-9,11-14,19,22-23,25H,10,15-18H2,1-3H3/t22-,23+,25+/m1/s1 | Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 2.38E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kentucky
Curated by ChEMBL
| Assay Description Inhibition of [3H]DA uptake at DAT in rat brain striatal synaptosomes by liquid scintillation spectrophotometry |
Bioorg Med Chem 18: 640-9 (2010)
Article DOI: 10.1016/j.bmc.2009.12.002 BindingDB Entry DOI: 10.7270/Q2XS5WB2 |
More data for this Ligand-Target Pair | |
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human)) | BDBM86207
(CAS_50-36-2 | COCAINE | NSC_446220)Show SMILES COC(=O)C1C2CCC(CC1OC(=O)c1ccccc1)N2C |TLB:2:4:20:7.6,11:10:20:7.6| Show InChI InChI=1S/C17H21NO4/c1-18-12-8-9-13(18)15(17(20)21-2)14(10-12)22-16(19)11-6-4-3-5-7-11/h3-7,12-15H,8-10H2,1-2H3 | Reactome pathway KEGG
UniProtKB/SwissProt
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PC cid PC sid PDB UniChem
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Similars
| Article PubMed
| 2.42E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kentucky
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 310: 1035-45 (2004)
Article DOI: 10.1124/jpet.104.068098 BindingDB Entry DOI: 10.7270/Q2WH2NJN |
More data for this Ligand-Target Pair | |
Synaptic vesicular amine transporter
(Rattus norvegicus (Rat)) | BDBM50309673
((2S,6S,2R)-2-[6-(2-(2-Naphthalene)-sulfonyloxy-2-p...)Show SMILES CN1[C@H](C[C@H](OS(=O)(=O)c2ccc3ccccc3c2)c2ccccc2)CCC[C@@H]1CC(=O)c1ccccc1 |r| Show InChI InChI=1S/C32H33NO4S/c1-33-28(22-31(34)25-12-4-2-5-13-25)17-10-18-29(33)23-32(26-14-6-3-7-15-26)37-38(35,36)30-20-19-24-11-8-9-16-27(24)21-30/h2-9,11-16,19-21,28-29,32H,10,17-18,22-23H2,1H3/t28-,29+,32+/m1/s1 | PDB
UniProtKB/SwissProt
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| CHEMBL PC cid PC sid UniChem
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| Article PubMed
| 2.48E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kentucky
Curated by ChEMBL
| Assay Description Displacement of [3HDTBZ from VMAT2 in rat whole brain vesicles by liquid scintillation spectrophotometry |
Bioorg Med Chem 18: 640-9 (2010)
Article DOI: 10.1016/j.bmc.2009.12.002 BindingDB Entry DOI: 10.7270/Q2XS5WB2 |
More data for this Ligand-Target Pair | |
Synaptic vesicular amine transporter
(Rattus norvegicus (Rat)) | BDBM50309686
((2S,6S,2R)-2-[6-(2-Isobutyryloxy-2-phenylethyl)-1-...)Show SMILES CC(C)C(=O)O[C@@H](C[C@@H]1CCC[C@H](CC(=O)c2ccccc2)N1C)c1ccccc1 |r| Show InChI InChI=1S/C26H33NO3/c1-19(2)26(29)30-25(21-13-8-5-9-14-21)18-23-16-10-15-22(27(23)3)17-24(28)20-11-6-4-7-12-20/h4-9,11-14,19,22-23,25H,10,15-18H2,1-3H3/t22-,23+,25+/m1/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 2.61E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kentucky
Curated by ChEMBL
| Assay Description Displacement of [3H]MTBZ from VMAT2 in rat whole brain vesicles by liquid scintillation spectrophotometry |
Bioorg Med Chem 18: 640-9 (2010)
Article DOI: 10.1016/j.bmc.2009.12.002 BindingDB Entry DOI: 10.7270/Q2XS5WB2 |
More data for this Ligand-Target Pair | |
Synaptic vesicular amine transporter
(Homo sapiens (Human)) | BDBM50422013
(LOBELINE | Lobeline Hydrochloride)Show SMILES CN1[C@@H](C[C@H](O)c2ccccc2)CCC[C@H]1CC(=O)c1ccccc1 Show InChI InChI=1S/C22H27NO2/c1-23-19(15-21(24)17-9-4-2-5-10-17)13-8-14-20(23)16-22(25)18-11-6-3-7-12-18/h2-7,9-12,19-21,24H,8,13-16H2,1H3/t19-,20+,21+/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
PC cid PC sid UniChem
Similars
| Article PubMed
| 2.76E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kentucky
Curated by ChEMBL
| Assay Description Binding affinity to VMAT2 receptor |
Bioorg Med Chem 18: 640-9 (2010)
Article DOI: 10.1016/j.bmc.2009.12.002 BindingDB Entry DOI: 10.7270/Q2XS5WB2 |
More data for this Ligand-Target Pair | |
Nicotinic acetylcholine receptor
(RAT) | BDBM50054820
(Methyllycaconitine | [(1S,4S,5R,6S,8R,9R,13S,16S,1...)Show SMILES CCN1C[C@]2(COC(=O)c3ccccc3-n3c(O)cc(C)c3O)CC[C@H](OC)[C@@]34C5C[C@H]6[C@H](OC)C5[C@](O)(C[C@@H]6OC)[C@](O)([C@@H](OC)C23)C14 |wU:4.4,42.46,36.39,44.48,39.43,wD:28.55,32.34,25.27,31.32,TLB:28:29:32:36.38.39,1:2:47:25.23.24,25:28:42.44:4.2.3,THB:42:48:47:25.23.24,29:28:42.44:4.2.3,2:48:36.35.29:47.44,(3.83,-6.7,;5.61,-4.92,;8.1,-4.92,;7.12,-7.5,;8.22,-6.42,;8.22,-7.94,;7.82,-9.45,;8.61,-10.78,;9.94,-10.01,;8.62,-12.33,;7.29,-13.1,;7.29,-14.64,;8.62,-15.41,;9.95,-14.64,;9.95,-13.1,;11.49,-13.09,;12.9,-13.7,;13.3,-15.19,;13.93,-12.55,;13.14,-11.22,;13.91,-9.88,;11.64,-11.55,;10.86,-10.2,;6.88,-5.65,;6.87,-4.11,;8.21,-3.34,;8.2,-1.8,;6.87,-1.03,;9.54,-4.11,;10.5,-3.18,;10.3,-1.71,;11.64,-1.06,;12.67,-2.15,;14.21,-2.15,;14.96,-3.46,;11.97,-3.45,;12.65,-4.9,;13.98,-5.67,;16.6,-3.1,;16.6,-1.56,;17.69,-.47,;19.02,-1.24,;11.93,-6.28,;12.7,-7.59,;10.46,-6.53,;10.06,-8.01,;11.39,-8.78,;9.55,-5.63,;9.53,-2.57,)| Show InChI InChI=1S/C37H50N2O10/c1-7-38-17-34(18-49-32(42)20-10-8-9-11-23(20)39-26(40)14-19(2)31(39)41)13-12-25(46-4)36-22-15-21-24(45-3)16-35(43,27(22)28(21)47-5)37(44,33(36)38)30(48-6)29(34)36/h8-11,14,21-22,24-25,27-30,33,40-41,43-44H,7,12-13,15-18H2,1-6H3/t21-,22?,24+,25+,27?,28+,29?,30+,33?,34+,35-,36+,37+/m1/s1 | UniProtKB/TrEMBL
GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| 2.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kentucky
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 302: 687-95 (2002)
Article DOI: 10.1124/jpet.302.2.687 BindingDB Entry DOI: 10.7270/Q21R6P3D |
More data for this Ligand-Target Pair | |
Synaptic vesicular amine transporter
(Rattus norvegicus (Rat)) | BDBM50309688
((2S,6S,2R)-2-[6-(2-Anisoyloxy-2-phenylethyl)-1-met...)Show SMILES COc1ccc(cc1)C(=O)O[C@@H](C[C@@H]1CCC[C@H](CC(=O)c2ccccc2)N1C)c1ccccc1 |r| Show InChI InChI=1S/C30H33NO4/c1-31-25(20-28(32)22-10-5-3-6-11-22)14-9-15-26(31)21-29(23-12-7-4-8-13-23)35-30(33)24-16-18-27(34-2)19-17-24/h3-8,10-13,16-19,25-26,29H,9,14-15,20-21H2,1-2H3/t25-,26+,29+/m1/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 2.98E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kentucky
Curated by ChEMBL
| Assay Description Displacement of [3H]MTBZ from VMAT2 in rat whole brain vesicles by liquid scintillation spectrophotometry |
Bioorg Med Chem 18: 640-9 (2010)
Article DOI: 10.1016/j.bmc.2009.12.002 BindingDB Entry DOI: 10.7270/Q2XS5WB2 |
More data for this Ligand-Target Pair | |
Synaptic vesicular amine transporter
(Rattus norvegicus (Rat)) | BDBM50309683
((2S,6S,2R)-2-[6-(2-p-Fluoro-benzenesulfonyloxy-2-p...)Show SMILES CN1[C@H](C[C@H](OS(=O)(=O)c2ccc(F)cc2)c2ccccc2)CCC[C@@H]1CC(=O)c1ccccc1 |r| Show InChI InChI=1S/C28H30FNO4S/c1-30-24(19-27(31)21-9-4-2-5-10-21)13-8-14-25(30)20-28(22-11-6-3-7-12-22)34-35(32,33)26-17-15-23(29)16-18-26/h2-7,9-12,15-18,24-25,28H,8,13-14,19-20H2,1H3/t24-,25+,28+/m1/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 3.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kentucky
Curated by ChEMBL
| Assay Description Displacement of [3HDTBZ from VMAT2 in rat whole brain vesicles by liquid scintillation spectrophotometry |
Bioorg Med Chem 18: 640-9 (2010)
Article DOI: 10.1016/j.bmc.2009.12.002 BindingDB Entry DOI: 10.7270/Q2XS5WB2 |
More data for this Ligand-Target Pair | |
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat)) | BDBM50309671
((2S,6S,2R)-2-[6-(2-(2-Thiophen)-carboxyl-2-phenyle...)Show SMILES CN1[C@H](C[C@H](OC(=O)c2cccs2)c2ccccc2)CCC[C@@H]1CC(=O)c1ccccc1 |r| Show InChI InChI=1S/C27H29NO3S/c1-28-22(18-24(29)20-10-4-2-5-11-20)14-8-15-23(28)19-25(21-12-6-3-7-13-21)31-27(30)26-16-9-17-32-26/h2-7,9-13,16-17,22-23,25H,8,14-15,18-19H2,1H3/t22-,23+,25+/m1/s1 | Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| 3.02E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kentucky
Curated by ChEMBL
| Assay Description Inhibition of [3H]DA uptake at DAT in rat brain striatal synaptosomes by liquid scintillation spectrophotometry |
Bioorg Med Chem 18: 640-9 (2010)
Article DOI: 10.1016/j.bmc.2009.12.002 BindingDB Entry DOI: 10.7270/Q2XS5WB2 |
More data for this Ligand-Target Pair | |
Synaptic vesicular amine transporter
(Rattus norvegicus (Rat)) | BDBM50309670
((2S,6S,2R)-2-[6-(2-p-Chloro-benzenesulfonyloxy-2-p...)Show SMILES CN1[C@H](C[C@H](OS(=O)(=O)c2ccc(Cl)cc2)c2ccccc2)CCC[C@@H]1CC(=O)c1ccccc1 |r| Show InChI InChI=1S/C28H30ClNO4S/c1-30-24(19-27(31)21-9-4-2-5-10-21)13-8-14-25(30)20-28(22-11-6-3-7-12-22)34-35(32,33)26-17-15-23(29)16-18-26/h2-7,9-12,15-18,24-25,28H,8,13-14,19-20H2,1H3/t24-,25+,28+/m1/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 3.24E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kentucky
Curated by ChEMBL
| Assay Description Displacement of [3HDTBZ from VMAT2 in rat whole brain vesicles by liquid scintillation spectrophotometry |
Bioorg Med Chem 18: 640-9 (2010)
Article DOI: 10.1016/j.bmc.2009.12.002 BindingDB Entry DOI: 10.7270/Q2XS5WB2 |
More data for this Ligand-Target Pair | |
Synaptic vesicular amine transporter
(Rattus norvegicus (Rat)) | BDBM50309682
((2S,6S,2R)-2-[6-(2-Butyryloxy-2-phenylethyl)-1-met...)Show SMILES CCCC(=O)O[C@@H](C[C@@H]1CCC[C@H](CC(=O)c2ccccc2)N1C)c1ccccc1 |r| Show InChI InChI=1S/C26H33NO3/c1-3-11-26(29)30-25(21-14-8-5-9-15-21)19-23-17-10-16-22(27(23)2)18-24(28)20-12-6-4-7-13-20/h4-9,12-15,22-23,25H,3,10-11,16-19H2,1-2H3/t22-,23+,25+/m1/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 3.38E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kentucky
Curated by ChEMBL
| Assay Description Displacement of [3H]MTBZ from VMAT2 in rat whole brain vesicles by liquid scintillation spectrophotometry |
Bioorg Med Chem 18: 640-9 (2010)
Article DOI: 10.1016/j.bmc.2009.12.002 BindingDB Entry DOI: 10.7270/Q2XS5WB2 |
More data for this Ligand-Target Pair | |
Synaptic vesicular amine transporter
(Rattus norvegicus (Rat)) | BDBM50309674
((2S,6S,2R)-2-[6-(2-Benzenesulfonyloxy-2-phenylethy...)Show SMILES CN1[C@H](C[C@H](OS(=O)(=O)c2ccccc2)c2ccccc2)CCC[C@@H]1CC(=O)c1ccccc1 |r| Show InChI InChI=1S/C28H31NO4S/c1-29-24(20-27(30)22-12-5-2-6-13-22)16-11-17-25(29)21-28(23-14-7-3-8-15-23)33-34(31,32)26-18-9-4-10-19-26/h2-10,12-15,18-19,24-25,28H,11,16-17,20-21H2,1H3/t24-,25+,28+/m1/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 3.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kentucky
Curated by ChEMBL
| Assay Description Displacement of [3HDTBZ from VMAT2 in rat whole brain vesicles by liquid scintillation spectrophotometry |
Bioorg Med Chem 18: 640-9 (2010)
Article DOI: 10.1016/j.bmc.2009.12.002 BindingDB Entry DOI: 10.7270/Q2XS5WB2 |
More data for this Ligand-Target Pair | |
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat)) | BDBM50309688
((2S,6S,2R)-2-[6-(2-Anisoyloxy-2-phenylethyl)-1-met...)Show SMILES COc1ccc(cc1)C(=O)O[C@@H](C[C@@H]1CCC[C@H](CC(=O)c2ccccc2)N1C)c1ccccc1 |r| Show InChI InChI=1S/C30H33NO4/c1-31-25(20-28(32)22-10-5-3-6-11-22)14-9-15-26(31)21-29(23-12-7-4-8-13-23)35-30(33)24-16-18-27(34-2)19-17-24/h3-8,10-13,16-19,25-26,29H,9,14-15,20-21H2,1-2H3/t25-,26+,29+/m1/s1 | Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 3.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kentucky
Curated by ChEMBL
| Assay Description Inhibition of [3H]DA uptake at DAT in rat brain striatal synaptosomes by liquid scintillation spectrophotometry |
Bioorg Med Chem 18: 640-9 (2010)
Article DOI: 10.1016/j.bmc.2009.12.002 BindingDB Entry DOI: 10.7270/Q2XS5WB2 |
More data for this Ligand-Target Pair | |
Synaptic vesicular amine transporter
(Rattus norvegicus (Rat)) | BDBM50309676
((2S,6S,2R)-2-[6-(2-Benzylsulfonyloxy-2-phenylethyl...)Show SMILES CN1[C@H](C[C@H](OS(=O)(=O)Cc2ccccc2)c2ccccc2)CCC[C@@H]1CC(=O)c1ccccc1 |r| Show InChI InChI=1S/C29H33NO4S/c1-30-26(20-28(31)24-14-7-3-8-15-24)18-11-19-27(30)21-29(25-16-9-4-10-17-25)34-35(32,33)22-23-12-5-2-6-13-23/h2-10,12-17,26-27,29H,11,18-22H2,1H3/t26-,27+,29+/m1/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 3.98E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kentucky
Curated by ChEMBL
| Assay Description Displacement of [3HDTBZ from VMAT2 in rat whole brain vesicles by liquid scintillation spectrophotometry |
Bioorg Med Chem 18: 640-9 (2010)
Article DOI: 10.1016/j.bmc.2009.12.002 BindingDB Entry DOI: 10.7270/Q2XS5WB2 |
More data for this Ligand-Target Pair | |