Compile Data Set for Download or QSAR

Found 645 hits with Last Name = 'miura' and Initial = 'j'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM50204291 (CHEMBL3953104 | US20230295171, Example 76) Show SMILES Cc1cccc(Nc2nc(N[C@@H]3CCCC[C@@H]3N)c(C#N)c3CNC(=O)c23)c1 |r| Show InChI InChI=1S/C21H24N6O/c1-12-5-4-6-13(9-12)25-20-18-15(11-24-21(18)28)14(10-22)19(27-20)26-17-8-3-2-7-16(17)23/h4-6,9,16-17H,2-3,7-8,11,23H2,1H3,(H,24,28)(H2,25,26,27)/t16-,17+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
Takeda California, Inc. Curated by ChEMBL					Assay Description Inhibition of human C-terminal 6His-tagged SYK (356 to 635 residues) expressed in Sf9 insect cells using 5-carboxyfluorescein(FAM)-EEPLYWSFPAKKK-NH2 ...				Bioorg Med Chem Lett 26: 5947-5950 (2016) Article DOI: 10.1016/j.bmcl.2016.10.087 BindingDB Entry DOI: 10.7270/Q29888Z2
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM50204296 (CHEMBL3941633 | US20230295171, Example 75) Show SMILES Cc1cccc(Nc2nc(N[C@@H]3CCCC[C@@H]3N)c(Cl)c3CNC(=O)c23)c1 |r| Show InChI InChI=1S/C20H24ClN5O/c1-11-5-4-6-12(9-11)24-18-16-13(10-23-20(16)27)17(21)19(26-18)25-15-8-3-2-7-14(15)22/h4-6,9,14-15H,2-3,7-8,10,22H2,1H3,(H,23,27)(H2,24,25,26)/t14-,15+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.800	n/a	n/a	n/a	n/a	n/a	n/a
Takeda California, Inc. Curated by ChEMBL					Assay Description Inhibition of human C-terminal 6His-tagged SYK (356 to 635 residues) expressed in Sf9 insect cells using 5-carboxyfluorescein(FAM)-EEPLYWSFPAKKK-NH2 ...				Bioorg Med Chem Lett 26: 5947-5950 (2016) Article DOI: 10.1016/j.bmcl.2016.10.087 BindingDB Entry DOI: 10.7270/Q29888Z2
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM620222 (BDBM50204292 | US20230295171, Example 82) Show SMILES Cc1cccc(Nc2nc(N[C@@H]3CCCC[C@@H]3N)c(-c3cn[nH]c3)c3CNC(=O)c23)c1 |r| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.900	n/a	n/a	n/a	n/a	n/a	n/a
Takeda California, Inc. Curated by ChEMBL					Assay Description Inhibition of human C-terminal 6His-tagged SYK (356 to 635 residues) expressed in Sf9 insect cells using 5-carboxyfluorescein(FAM)-EEPLYWSFPAKKK-NH2 ...				Bioorg Med Chem Lett 26: 5947-5950 (2016) Article DOI: 10.1016/j.bmcl.2016.10.087 BindingDB Entry DOI: 10.7270/Q29888Z2
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM50204293 (CHEMBL3983415 | US20230295171, Example 25) Show SMILES Cc1cccc(Nc2nc(N[C@@H]3CCCC[C@@H]3N)c(F)c3CNC(=O)c23)c1 |r| Show InChI InChI=1S/C20H24FN5O/c1-11-5-4-6-12(9-11)24-18-16-13(10-23-20(16)27)17(21)19(26-18)25-15-8-3-2-7-14(15)22/h4-6,9,14-15H,2-3,7-8,10,22H2,1H3,(H,23,27)(H2,24,25,26)/t14-,15+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a	n/a
Takeda California, Inc. Curated by ChEMBL					Assay Description Inhibition of human C-terminal 6His-tagged SYK (356 to 635 residues) expressed in Sf9 insect cells using 5-carboxyfluorescein(FAM)-EEPLYWSFPAKKK-NH2 ...				Bioorg Med Chem Lett 26: 5947-5950 (2016) Article DOI: 10.1016/j.bmcl.2016.10.087 BindingDB Entry DOI: 10.7270/Q29888Z2
					More data for this Ligand-Target Pair
Egl nine homolog 1 [181-417] (Homo sapiens (Human))	BDBM413341 ((S)-6-(4-(4-cyanophenyl)-5-hydroxy-1H-pyrazol-1-yl...) Show SMILES COCC[C@H](C)NC(=O)c1ccc(nc1)-n1ncc(c1O)-c1ccc(cc1)C#N |r| Show InChI InChI=1S/C21H21N5O3/c1-14(9-10-29-2)25-20(27)17-7-8-19(23-12-17)26-21(28)18(13-24-26)16-5-3-15(11-22)4-6-16/h3-8,12-14,28H,9-10H2,1-2H3,(H,25,27)/t14-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	1.78	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited US Patent					Assay Description The IC50 values for the PHD2 enzyme (residues 181-417) were determined by mixing increasing amounts of inhibitor with a fixed amount of enzyme (5 nM,...				US Patent US10407409 (2019) BindingDB Entry DOI: 10.7270/Q2D79DR0
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM50204290 (CHEMBL3979920 | US11077111, Compound IIIa | US2023...) Show SMILES Cn1cc(cn1)-c1nc(N[C@@H]2CCCC[C@@H]2N)c(F)c2CNC(=O)c12 |r| Show InChI InChI=1S/C17H21FN6O/c1-24-8-9(6-21-24)15-13-10(7-20-17(13)25)14(18)16(23-15)22-12-5-3-2-4-11(12)19/h6,8,11-12H,2-5,7,19H2,1H3,(H,20,25)(H,22,23)/t11-,12+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Takeda California, Inc. Curated by ChEMBL					Assay Description Inhibition of human recombinant full length N-terminal GST-tagged SYK cytoplasmic domain expressed in baculovirus expression system by Z'-LYTE assay				Bioorg Med Chem Lett 26: 5947-5950 (2016) Article DOI: 10.1016/j.bmcl.2016.10.087 BindingDB Entry DOI: 10.7270/Q29888Z2
					More data for this Ligand-Target Pair				3D Structure (crystal)
Egl nine homolog 1 [181-417] (Homo sapiens (Human))	BDBM413007 (6-(4-(4-cyano-2-methylphenyl)-5-hydroxy-1H-pyrazol...) Show SMILES CN(C)C(=O)c1ccc(nc1)-n1ncc(c1O)-c1ccc(cc1C)C#N Show InChI InChI=1S/C19H17N5O2/c1-12-8-13(9-20)4-6-15(12)16-11-22-24(19(16)26)17-7-5-14(10-21-17)18(25)23(2)3/h4-8,10-11,26H,1-3H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	2.14	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited US Patent					Assay Description The IC50 values for the PHD2 enzyme (residues 181-417) were determined by mixing increasing amounts of inhibitor with a fixed amount of enzyme (5 nM,...				US Patent US10407409 (2019) BindingDB Entry DOI: 10.7270/Q2D79DR0
					More data for this Ligand-Target Pair
Egl nine homolog 1 [181-417] (Homo sapiens (Human))	BDBM413146 (2-fluoro-4-(5-hydroxy-1-(5-(morpholine-4-carbonyl)...) Show SMILES Cc1cc(C#N)c(F)cc1-c1cnn(c1O)-c1ccc(cn1)C(=O)N1CCOCC1 Show InChI InChI=1S/C21H18FN5O3/c1-13-8-15(10-23)18(22)9-16(13)17-12-25-27(21(17)29)19-3-2-14(11-24-19)20(28)26-4-6-30-7-5-26/h2-3,8-9,11-12,29H,4-7H2,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	2.24	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited US Patent					Assay Description The IC50 values for the PHD2 enzyme (residues 181-417) were determined by mixing increasing amounts of inhibitor with a fixed amount of enzyme (5 nM,...				US Patent US10407409 (2019) BindingDB Entry DOI: 10.7270/Q2D79DR0
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM50204295 (CHEMBL3944381) Show SMILES N[C@H]1CCCC[C@H]1Nc1nc(-c2cnn3ccccc23)c2C(=O)NCc2c1C#N |r| Show InChI InChI=1S/C21H21N7O/c22-9-12-13-10-24-21(29)18(13)19(14-11-25-28-8-4-3-7-17(14)28)27-20(12)26-16-6-2-1-5-15(16)23/h3-4,7-8,11,15-16H,1-2,5-6,10,23H2,(H,24,29)(H,26,27)/t15-,16+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.30	n/a	n/a	n/a	n/a	n/a	n/a
Takeda California, Inc. Curated by ChEMBL					Assay Description Inhibition of human C-terminal 6His-tagged SYK (356 to 635 residues) expressed in Sf9 insect cells using 5-carboxyfluorescein(FAM)-EEPLYWSFPAKKK-NH2 ...				Bioorg Med Chem Lett 26: 5947-5950 (2016) Article DOI: 10.1016/j.bmcl.2016.10.087 BindingDB Entry DOI: 10.7270/Q29888Z2
					More data for this Ligand-Target Pair
Egl nine homolog 1 [181-417] (Homo sapiens (Human))	BDBM413152 (2-fluoro-4-(5-hydroxy-1-(5-(4-methyl-4,7-diazaspir...) Show SMILES CN1CCN(CC11CC1)C(=O)c1ccc(nc1)-n1ncc(c1O)-c1cc(F)c(cc1C)C#N Show InChI InChI=1S/C24H23FN6O2/c1-15-9-17(11-26)20(25)10-18(15)19-13-28-31(23(19)33)21-4-3-16(12-27-21)22(32)30-8-7-29(2)24(14-30)5-6-24/h3-4,9-10,12-13,33H,5-8,14H2,1-2H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	2.34	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited US Patent					Assay Description The IC50 values for the PHD2 enzyme (residues 181-417) were determined by mixing increasing amounts of inhibitor with a fixed amount of enzyme (5 nM,...				US Patent US10407409 (2019) BindingDB Entry DOI: 10.7270/Q2D79DR0
					More data for this Ligand-Target Pair
Egl nine homolog 1 [181-417] (Homo sapiens (Human))	BDBM413246 (4-(5-hydroxy-1-(5-(4-propylpiperazine-1-carbonyl)p...) Show SMILES CCCN1CCN(CC1)C(=O)c1ccc(nc1)-n1ncc(c1O)-c1ccc(cc1C)C#N Show InChI InChI=1S/C24H26N6O2/c1-3-8-28-9-11-29(12-10-28)23(31)19-5-7-22(26-15-19)30-24(32)21(16-27-30)20-6-4-18(14-25)13-17(20)2/h4-7,13,15-16,32H,3,8-12H2,1-2H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	2.51	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited US Patent					Assay Description The IC50 values for the PHD2 enzyme (residues 181-417) were determined by mixing increasing amounts of inhibitor with a fixed amount of enzyme (5 nM,...				US Patent US10407409 (2019) BindingDB Entry DOI: 10.7270/Q2D79DR0
					More data for this Ligand-Target Pair
Egl nine homolog 1 [181-417] (Homo sapiens (Human))	BDBM413353 ((S)-6-(4-(4-cyano-2-methylphenyl)-5-hydroxy-1H-pyr...) Show SMILES COCC[C@H](C)NC(=O)c1ccc(nc1)-n1ncc(c1O)-c1ccc(cc1C)C#N |r| Show InChI InChI=1S/C22H23N5O3/c1-14-10-16(11-23)4-6-18(14)19-13-25-27(22(19)29)20-7-5-17(12-24-20)21(28)26-15(2)8-9-30-3/h4-7,10,12-13,15,29H,8-9H2,1-3H3,(H,26,28)/t15-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	2.51	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited US Patent					Assay Description The IC50 values for the PHD2 enzyme (residues 181-417) were determined by mixing increasing amounts of inhibitor with a fixed amount of enzyme (5 nM,...				US Patent US10407409 (2019) BindingDB Entry DOI: 10.7270/Q2D79DR0
					More data for this Ligand-Target Pair
Egl nine homolog 1 [181-417] (Homo sapiens (Human))	BDBM413134 (2-fluoro-4-(5-hydroxy-1-(5-(4-methylpiperazine-1-c...) Show SMILES CN1CCN(CC1)C(=O)c1ccc(nc1)-n1ncc(c1O)-c1cc(F)c(cc1C)C#N Show InChI InChI=1S/C22H21FN6O2/c1-14-9-16(11-24)19(23)10-17(14)18-13-26-29(22(18)31)20-4-3-15(12-25-20)21(30)28-7-5-27(2)6-8-28/h3-4,9-10,12-13,31H,5-8H2,1-2H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	2.57	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited US Patent					Assay Description The IC50 values for the PHD2 enzyme (residues 181-417) were determined by mixing increasing amounts of inhibitor with a fixed amount of enzyme (5 nM,...				US Patent US10407409 (2019) BindingDB Entry DOI: 10.7270/Q2D79DR0
					More data for this Ligand-Target Pair
Egl nine homolog 1 [181-417] (Homo sapiens (Human))	BDBM413193 ((S)-4-(1-(5-(3-((2,2-difluoroethyl)(methyl)amino)p...) Show SMILES CN(CC(F)F)[C@H]1CCCN(C1)C(=O)c1ccc(nc1)-n1ncc(c1O)-c1ccc(C#N)c(F)c1C |r| Show InChI InChI=1S/C25H25F3N6O2/c1-15-19(7-5-16(10-29)23(15)28)20-12-31-34(25(20)36)22-8-6-17(11-30-22)24(35)33-9-3-4-18(13-33)32(2)14-21(26)27/h5-8,11-12,18,21,36H,3-4,9,13-14H2,1-2H3/t18-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	2.82	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited US Patent					Assay Description The IC50 values for the PHD2 enzyme (residues 181-417) were determined by mixing increasing amounts of inhibitor with a fixed amount of enzyme (5 nM,...				US Patent US10407409 (2019) BindingDB Entry DOI: 10.7270/Q2D79DR0
					More data for this Ligand-Target Pair
Egl nine homolog 1 [181-417] (Homo sapiens (Human))	BDBM413139 (2-fluoro-4-(5-hydroxy-1-(5-(4-methyl-4,7-diazaspir...) Show SMILES CN1CCN(CC11CC1)C(=O)c1ccc(nc1)-n1ncc(c1O)-c1ccc(C#N)c(F)c1C Show InChI InChI=1S/C24H23FN6O2/c1-15-18(5-3-16(11-26)21(15)25)19-13-28-31(23(19)33)20-6-4-17(12-27-20)22(32)30-10-9-29(2)24(14-30)7-8-24/h3-6,12-13,33H,7-10,14H2,1-2H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	2.88	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited US Patent					Assay Description The IC50 values for the PHD2 enzyme (residues 181-417) were determined by mixing increasing amounts of inhibitor with a fixed amount of enzyme (5 nM,...				US Patent US10407409 (2019) BindingDB Entry DOI: 10.7270/Q2D79DR0
					More data for this Ligand-Target Pair
Egl nine homolog 1 [181-417] (Homo sapiens (Human))	BDBM413210 ((R)-4-(1-(5-(3-((2,2-difluoroethyl)(methyl)amino)p...) Show SMILES CN(CC(F)F)[C@@H]1CCCN(C1)C(=O)c1ccc(nc1)-n1ncc(c1O)-c1ccc(C#N)c(F)c1C |r| Show InChI InChI=1S/C25H25F3N6O2/c1-15-19(7-5-16(10-29)23(15)28)20-12-31-34(25(20)36)22-8-6-17(11-30-22)24(35)33-9-3-4-18(13-33)32(2)14-21(26)27/h5-8,11-12,18,21,36H,3-4,9,13-14H2,1-2H3/t18-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	2.95	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited US Patent					Assay Description The IC50 values for the PHD2 enzyme (residues 181-417) were determined by mixing increasing amounts of inhibitor with a fixed amount of enzyme (5 nM,...				US Patent US10407409 (2019) BindingDB Entry DOI: 10.7270/Q2D79DR0
					More data for this Ligand-Target Pair
Microtubule-associated protein 2 (Homo sapiens (Human))	BDBM50167916 (CHEMBL3798615) Show SMILES FC(F)(F)c1cc(-c2cncc(c2)C#N)c2cn[nH]c2c1 Show InChI InChI=1S/C14H7F3N4/c15-14(16,17)10-2-11(12-7-20-21-13(12)3-10)9-1-8(4-18)5-19-6-9/h1-3,5-7H,(H,20,21)	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Takeda California Curated by ChEMBL					Assay Description Reversal inhibition of full length recombinant human MetAP2 expressed in baculovirus infected insect Sf9 cells using Met-AMC as substrate measured fo...				Bioorg Med Chem Lett 26: 2774-2778 (2016) Article DOI: 10.1016/j.bmcl.2016.04.073 BindingDB Entry DOI: 10.7270/Q2DF6T4T
					More data for this Ligand-Target Pair
Egl nine homolog 1 [181-417] (Homo sapiens (Human))	BDBM413140 ((S)-4-(1-(5-(4-ethyl-3-methylpiperazine-1-carbonyl...) Show SMILES CCN1CCN(C[C@@H]1C)C(=O)c1ccc(nc1)-n1ncc(c1O)-c1cc(F)c(cc1C)C#N |r| Show InChI InChI=1S/C24H25FN6O2/c1-4-29-7-8-30(14-16(29)3)23(32)17-5-6-22(27-12-17)31-24(33)20(13-28-31)19-10-21(25)18(11-26)9-15(19)2/h5-6,9-10,12-13,16,33H,4,7-8,14H2,1-3H3/t16-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	3.02	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited US Patent					Assay Description The IC50 values for the PHD2 enzyme (residues 181-417) were determined by mixing increasing amounts of inhibitor with a fixed amount of enzyme (5 nM,...				US Patent US10407409 (2019) BindingDB Entry DOI: 10.7270/Q2D79DR0
					More data for this Ligand-Target Pair
Egl nine homolog 1 [181-417] (Homo sapiens (Human))	BDBM413063 (4-(1-(5-(4-(2,2-difluoroethyl)piperazine-1-carbony...) Show SMILES Cc1cc(ccc1-c1cnn(c1O)-c1ccc(cn1)C(=O)N1CCN(CC(F)F)CC1)C#N Show InChI InChI=1S/C23H22F2N6O2/c1-15-10-16(11-26)2-4-18(15)19-13-28-31(23(19)33)21-5-3-17(12-27-21)22(32)30-8-6-29(7-9-30)14-20(24)25/h2-5,10,12-13,20,33H,6-9,14H2,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	3.09	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited US Patent					Assay Description The IC50 values for the PHD2 enzyme (residues 181-417) were determined by mixing increasing amounts of inhibitor with a fixed amount of enzyme (5 nM,...				US Patent US10407409 (2019) BindingDB Entry DOI: 10.7270/Q2D79DR0
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM50204288 (CHEMBL3925430 | US20230295171, Example 88) Show SMILES Cc1cccc(Nc2nc(N[C@@H]3CCCC[C@@H]3N)c(C)c3CNC(=O)c23)c1 |r| Show InChI InChI=1S/C21H27N5O/c1-12-6-5-7-14(10-12)24-20-18-15(11-23-21(18)27)13(2)19(26-20)25-17-9-4-3-8-16(17)22/h5-7,10,16-17H,3-4,8-9,11,22H2,1-2H3,(H,23,27)(H2,24,25,26)/t16-,17+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.10	n/a	n/a	n/a	n/a	n/a	n/a
Takeda California, Inc. Curated by ChEMBL					Assay Description Inhibition of human C-terminal 6His-tagged SYK (356 to 635 residues) expressed in Sf9 insect cells using 5-carboxyfluorescein(FAM)-EEPLYWSFPAKKK-NH2 ...				Bioorg Med Chem Lett 26: 5947-5950 (2016) Article DOI: 10.1016/j.bmcl.2016.10.087 BindingDB Entry DOI: 10.7270/Q29888Z2
					More data for this Ligand-Target Pair
Egl nine homolog 1 [181-417] (Homo sapiens (Human))	BDBM413069 (4-(5-hydroxy-1-(5-(4-(2,2,2-trifluoroethyl)piperaz...) Show SMILES Cc1cc(ccc1-c1cnn(c1O)-c1ccc(cn1)C(=O)N1CCN(CC(F)(F)F)CC1)C#N Show InChI InChI=1S/C23H21F3N6O2/c1-15-10-16(11-27)2-4-18(15)19-13-29-32(22(19)34)20-5-3-17(12-28-20)21(33)31-8-6-30(7-9-31)14-23(24,25)26/h2-5,10,12-13,34H,6-9,14H2,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	3.16	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited US Patent					Assay Description The IC50 values for the PHD2 enzyme (residues 181-417) were determined by mixing increasing amounts of inhibitor with a fixed amount of enzyme (5 nM,...				US Patent US10407409 (2019) BindingDB Entry DOI: 10.7270/Q2D79DR0
					More data for this Ligand-Target Pair
Egl nine homolog 1 [181-417] (Homo sapiens (Human))	BDBM413199 ((R)-2-fluoro-4-(5-hydroxy-1-(5-(octahydropyrrolo[1...) Show SMILES Cc1c(F)c(ccc1-c1cnn(c1O)-c1ccc(cn1)C(=O)N1CCN2CCC[C@@H]2C1)C#N |r| Show InChI InChI=1S/C24H23FN6O2/c1-15-19(6-4-16(11-26)22(15)25)20-13-28-31(24(20)33)21-7-5-17(12-27-21)23(32)30-10-9-29-8-2-3-18(29)14-30/h4-7,12-13,18,33H,2-3,8-10,14H2,1H3/t18-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	3.16	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited US Patent					Assay Description The IC50 values for the PHD2 enzyme (residues 181-417) were determined by mixing increasing amounts of inhibitor with a fixed amount of enzyme (5 nM,...				US Patent US10407409 (2019) BindingDB Entry DOI: 10.7270/Q2D79DR0
					More data for this Ligand-Target Pair
Egl nine homolog 1 [181-417] (Homo sapiens (Human))	BDBM413169 ((S)-4-(1-(5-(3,4-dimethylpiperazine-1-carbonyl)pyr...) Show SMILES C[C@H]1CN(CCN1C)C(=O)c1ccc(nc1)-n1ncc(c1O)-c1ccc(C#N)c(F)c1C |r| Show InChI InChI=1S/C23H23FN6O2/c1-14-13-29(9-8-28(14)3)22(31)17-5-7-20(26-11-17)30-23(32)19(12-27-30)18-6-4-16(10-25)21(24)15(18)2/h4-7,11-12,14,32H,8-9,13H2,1-3H3/t14-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	3.16	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited US Patent					Assay Description The IC50 values for the PHD2 enzyme (residues 181-417) were determined by mixing increasing amounts of inhibitor with a fixed amount of enzyme (5 nM,...				US Patent US10407409 (2019) BindingDB Entry DOI: 10.7270/Q2D79DR0
					More data for this Ligand-Target Pair
Egl nine homolog 1 [181-417] (Homo sapiens (Human))	BDBM413158 ((S)-4-(1-(5-(3,4-dimethylpiperazine-1-carbonyl)pyr...) Show SMILES C[C@H]1CN(CCN1C)C(=O)c1ccc(nc1)-n1ncc(c1O)-c1cc(F)c(cc1C)C#N |r| Show InChI InChI=1S/C23H23FN6O2/c1-14-8-17(10-25)20(24)9-18(14)19-12-27-30(23(19)32)21-5-4-16(11-26-21)22(31)29-7-6-28(3)15(2)13-29/h4-5,8-9,11-12,15,32H,6-7,13H2,1-3H3/t15-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	3.16	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited US Patent					Assay Description The IC50 values for the PHD2 enzyme (residues 181-417) were determined by mixing increasing amounts of inhibitor with a fixed amount of enzyme (5 nM,...				US Patent US10407409 (2019) BindingDB Entry DOI: 10.7270/Q2D79DR0
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM50204290 (CHEMBL3979920 | US11077111, Compound IIIa | US2023...) Show SMILES Cn1cc(cn1)-c1nc(N[C@@H]2CCCC[C@@H]2N)c(F)c2CNC(=O)c12 |r| Show InChI InChI=1S/C17H21FN6O/c1-24-8-9(6-21-24)15-13-10(7-20-17(13)25)14(18)16(23-15)22-12-5-3-2-4-11(12)19/h6,8,11-12H,2-5,7,19H2,1H3,(H,20,25)(H,22,23)/t11-,12+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	3.20	n/a	n/a	n/a	n/a	n/a	n/a
Takeda California, Inc. Curated by ChEMBL					Assay Description Inhibition of human C-terminal 6His-tagged SYK (356 to 635 residues) expressed in Sf9 insect cells using 5-carboxyfluorescein(FAM)-EEPLYWSFPAKKK-NH2 ...				Bioorg Med Chem Lett 26: 5947-5950 (2016) Article DOI: 10.1016/j.bmcl.2016.10.087 BindingDB Entry DOI: 10.7270/Q29888Z2
					More data for this Ligand-Target Pair				3D Structure (crystal)
Egl nine homolog 1 [181-417] (Homo sapiens (Human))	BDBM413194 (6-(4-(4-cyano-3-fluoro-2-methylphenyl)-5-hydroxy-1...) Show SMILES COCCCNC(=O)c1ccc(nc1)-n1ncc(c1O)-c1ccc(C#N)c(F)c1C Show InChI InChI=1S/C21H20FN5O3/c1-13-16(6-4-14(10-23)19(13)22)17-12-26-27(21(17)29)18-7-5-15(11-25-18)20(28)24-8-3-9-30-2/h4-7,11-12,29H,3,8-9H2,1-2H3,(H,24,28)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	3.24	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited US Patent					Assay Description The IC50 values for the PHD2 enzyme (residues 181-417) were determined by mixing increasing amounts of inhibitor with a fixed amount of enzyme (5 nM,...				US Patent US10407409 (2019) BindingDB Entry DOI: 10.7270/Q2D79DR0
					More data for this Ligand-Target Pair
Egl nine homolog 1 [181-417] (Homo sapiens (Human))	BDBM413340 (6-(4-(4-cyano-2-fluorophenyl)-5-hydroxy-1H-pyrazol...) Show SMILES COCCCCNC(=O)c1ccc(nc1)-n1ncc(c1O)-c1ccc(cc1F)C#N Show InChI InChI=1S/C21H20FN5O3/c1-30-9-3-2-8-24-20(28)15-5-7-19(25-12-15)27-21(29)17(13-26-27)16-6-4-14(11-23)10-18(16)22/h4-7,10,12-13,29H,2-3,8-9H2,1H3,(H,24,28)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	3.31	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited US Patent					Assay Description The IC50 values for the PHD2 enzyme (residues 181-417) were determined by mixing increasing amounts of inhibitor with a fixed amount of enzyme (5 nM,...				US Patent US10407409 (2019) BindingDB Entry DOI: 10.7270/Q2D79DR0
					More data for this Ligand-Target Pair
Egl nine homolog 1 [181-417] (Homo sapiens (Human))	BDBM413128 ((R)-4-(1-(5-(4-ethyl-3-methylpiperazine-1-carbonyl...) Show SMILES CCN1CCN(C[C@H]1C)C(=O)c1ccc(nc1)-n1ncc(c1O)-c1cc(F)c(cc1C)C#N |r| Show InChI InChI=1S/C24H25FN6O2/c1-4-29-7-8-30(14-16(29)3)23(32)17-5-6-22(27-12-17)31-24(33)20(13-28-31)19-10-21(25)18(11-26)9-15(19)2/h5-6,9-10,12-13,16,33H,4,7-8,14H2,1-3H3/t16-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	3.31	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited US Patent					Assay Description The IC50 values for the PHD2 enzyme (residues 181-417) were determined by mixing increasing amounts of inhibitor with a fixed amount of enzyme (5 nM,...				US Patent US10407409 (2019) BindingDB Entry DOI: 10.7270/Q2D79DR0
					More data for this Ligand-Target Pair
Egl nine homolog 1 [181-417] (Homo sapiens (Human))	BDBM413200 (4-(5-hydroxy-1-(5-(octahydropyrrolo[1,2-a]pyrazine...) Show SMILES Cc1cc(ccc1-c1cnn(c1O)-c1ccc(cn1)C(=O)N1CCN2CCCC2C1)C#N Show InChI InChI=1S/C24H24N6O2/c1-16-11-17(12-25)4-6-20(16)21-14-27-30(24(21)32)22-7-5-18(13-26-22)23(31)29-10-9-28-8-2-3-19(28)15-29/h4-7,11,13-14,19,32H,2-3,8-10,15H2,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	3.31	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited US Patent					Assay Description The IC50 values for the PHD2 enzyme (residues 181-417) were determined by mixing increasing amounts of inhibitor with a fixed amount of enzyme (5 nM,...				US Patent US10407409 (2019) BindingDB Entry DOI: 10.7270/Q2D79DR0
					More data for this Ligand-Target Pair
Egl nine homolog 1 [181-417] (Homo sapiens (Human))	BDBM413188 (6-(4-(4-cyano-5-fluoro-2-methylphenyl)-5-hydroxy-1...) Show SMILES COCCCNC(=O)c1ccc(nc1)-n1ncc(c1O)-c1cc(F)c(cc1C)C#N Show InChI InChI=1S/C21H20FN5O3/c1-13-8-15(10-23)18(22)9-16(13)17-12-26-27(21(17)29)19-5-4-14(11-25-19)20(28)24-6-3-7-30-2/h4-5,8-9,11-12,29H,3,6-7H2,1-2H3,(H,24,28)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	3.31	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited US Patent					Assay Description The IC50 values for the PHD2 enzyme (residues 181-417) were determined by mixing increasing amounts of inhibitor with a fixed amount of enzyme (5 nM,...				US Patent US10407409 (2019) BindingDB Entry DOI: 10.7270/Q2D79DR0
					More data for this Ligand-Target Pair
Egl nine homolog 1 [181-417] (Homo sapiens (Human))	BDBM413239 ((S)-4-(1-(5-(4-ethyl-2-methylpiperazine-1-carbonyl...) Show SMILES CCN1CCN([C@@H](C)C1)C(=O)c1ccc(nc1)-n1ncc(c1O)-c1ccc(C#N)c(F)c1C |r| Show InChI InChI=1S/C24H25FN6O2/c1-4-29-9-10-30(15(2)14-29)23(32)18-6-8-21(27-12-18)31-24(33)20(13-28-31)19-7-5-17(11-26)22(25)16(19)3/h5-8,12-13,15,33H,4,9-10,14H2,1-3H3/t15-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	3.39	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited US Patent					Assay Description The IC50 values for the PHD2 enzyme (residues 181-417) were determined by mixing increasing amounts of inhibitor with a fixed amount of enzyme (5 nM,...				US Patent US10407409 (2019) BindingDB Entry DOI: 10.7270/Q2D79DR0
					More data for this Ligand-Target Pair
Egl nine homolog 1 [181-417] (Homo sapiens (Human))	BDBM413187 ((S)-2-fluoro-4-(5-hydroxy-1-(5-(3-(methyl(2,2,2-tr...) Show SMILES CN(CC(F)(F)F)[C@H]1CCCN(C1)C(=O)c1ccc(nc1)-n1ncc(c1O)-c1ccc(C#N)c(F)c1C |r| Show InChI InChI=1S/C25H24F4N6O2/c1-15-19(7-5-16(10-30)22(15)26)20-12-32-35(24(20)37)21-8-6-17(11-31-21)23(36)34-9-3-4-18(13-34)33(2)14-25(27,28)29/h5-8,11-12,18,37H,3-4,9,13-14H2,1-2H3/t18-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	3.39	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited US Patent					Assay Description The IC50 values for the PHD2 enzyme (residues 181-417) were determined by mixing increasing amounts of inhibitor with a fixed amount of enzyme (5 nM,...				US Patent US10407409 (2019) BindingDB Entry DOI: 10.7270/Q2D79DR0
					More data for this Ligand-Target Pair
Egl nine homolog 1 [181-417] (Homo sapiens (Human))	BDBM413157 (2-fluoro-4-(5-hydroxy-1-(5-(morpholine-4-carbonyl)...) Show SMILES Cc1c(F)c(ccc1-c1cnn(c1O)-c1ccc(cn1)C(=O)N1CCOCC1)C#N Show InChI InChI=1S/C21H18FN5O3/c1-13-16(4-2-14(10-23)19(13)22)17-12-25-27(21(17)29)18-5-3-15(11-24-18)20(28)26-6-8-30-9-7-26/h2-5,11-12,29H,6-9H2,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	3.39	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited US Patent					Assay Description The IC50 values for the PHD2 enzyme (residues 181-417) were determined by mixing increasing amounts of inhibitor with a fixed amount of enzyme (5 nM,...				US Patent US10407409 (2019) BindingDB Entry DOI: 10.7270/Q2D79DR0
					More data for this Ligand-Target Pair
Egl nine homolog 1 [181-417] (Homo sapiens (Human))	BDBM412995 (4-(1-(5-(6,6-difluoro-4-methyl-1,4-diazepane-1-car...) Show SMILES CN1CCN(CC(F)(F)C1)C(=O)c1ccc(nc1)-n1ncc(c1O)-c1ccc(cc1C)C#N Show InChI InChI=1S/C23H22F2N6O2/c1-15-9-16(10-26)3-5-18(15)19-12-28-31(22(19)33)20-6-4-17(11-27-20)21(32)30-8-7-29(2)13-23(24,25)14-30/h3-6,9,11-12,33H,7-8,13-14H2,1-2H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	3.47	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited US Patent					Assay Description The IC50 values for the PHD2 enzyme (residues 181-417) were determined by mixing increasing amounts of inhibitor with a fixed amount of enzyme (5 nM,...				US Patent US10407409 (2019) BindingDB Entry DOI: 10.7270/Q2D79DR0
					More data for this Ligand-Target Pair
Egl nine homolog 1 [181-417] (Homo sapiens (Human))	BDBM413335 ((R)-6-(4-(4-cyanophenyl)-5-hydroxy-1H-pyrazol-1-yl...) Show SMILES COCC[C@@H](C)NC(=O)c1ccc(nc1)-n1ncc(c1O)-c1ccc(cc1)C#N |r| Show InChI InChI=1S/C21H21N5O3/c1-14(9-10-29-2)25-20(27)17-7-8-19(23-12-17)26-21(28)18(13-24-26)16-5-3-15(11-22)4-6-16/h3-8,12-14,28H,9-10H2,1-2H3,(H,25,27)/t14-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	3.47	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited US Patent					Assay Description The IC50 values for the PHD2 enzyme (residues 181-417) were determined by mixing increasing amounts of inhibitor with a fixed amount of enzyme (5 nM,...				US Patent US10407409 (2019) BindingDB Entry DOI: 10.7270/Q2D79DR0
					More data for this Ligand-Target Pair
Egl nine homolog 1 [181-417] (Homo sapiens (Human))	BDBM413347 ((R)-6-(4-(4-cyano-2-methylphenyl)-5-hydroxy-1H-pyr...) Show SMILES COCC[C@@H](C)NC(=O)c1ccc(nc1)-n1ncc(c1O)-c1ccc(cc1C)C#N |r| Show InChI InChI=1S/C22H23N5O3/c1-14-10-16(11-23)4-6-18(14)19-13-25-27(22(19)29)20-7-5-17(12-24-20)21(28)26-15(2)8-9-30-3/h4-7,10,12-13,15,29H,8-9H2,1-3H3,(H,26,28)/t15-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	3.55	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited US Patent					Assay Description The IC50 values for the PHD2 enzyme (residues 181-417) were determined by mixing increasing amounts of inhibitor with a fixed amount of enzyme (5 nM,...				US Patent US10407409 (2019) BindingDB Entry DOI: 10.7270/Q2D79DR0
					More data for this Ligand-Target Pair
Egl nine homolog 1 [181-417] (Homo sapiens (Human))	BDBM413023 (4-(5-hydroxy-1-(5-(3,3,4-trimethylpiperazine-1-car...) Show SMILES CN1CCN(CC1(C)C)C(=O)c1ccc(nc1)-n1ncc(c1O)-c1ccc(cc1C)C#N Show InChI InChI=1S/C24H26N6O2/c1-16-11-17(12-25)5-7-19(16)20-14-27-30(23(20)32)21-8-6-18(13-26-21)22(31)29-10-9-28(4)24(2,3)15-29/h5-8,11,13-14,32H,9-10,15H2,1-4H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	3.63	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited US Patent					Assay Description The IC50 values for the PHD2 enzyme (residues 181-417) were determined by mixing increasing amounts of inhibitor with a fixed amount of enzyme (5 nM,...				US Patent US10407409 (2019) BindingDB Entry DOI: 10.7270/Q2D79DR0
					More data for this Ligand-Target Pair
Egl nine homolog 1 [181-417] (Homo sapiens (Human))	BDBM413145 (2-fluoro-4-(5-hydroxy-1-(5-(pyrrolidine-1-carbonyl...) Show SMILES Cc1c(F)c(ccc1-c1cnn(c1O)-c1ccc(cn1)C(=O)N1CCCC1)C#N Show InChI InChI=1S/C21H18FN5O2/c1-13-16(6-4-14(10-23)19(13)22)17-12-25-27(21(17)29)18-7-5-15(11-24-18)20(28)26-8-2-3-9-26/h4-7,11-12,29H,2-3,8-9H2,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	3.63	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited US Patent					Assay Description The IC50 values for the PHD2 enzyme (residues 181-417) were determined by mixing increasing amounts of inhibitor with a fixed amount of enzyme (5 nM,...				US Patent US10407409 (2019) BindingDB Entry DOI: 10.7270/Q2D79DR0
					More data for this Ligand-Target Pair
Egl nine homolog 1 [181-417] (Homo sapiens (Human))	BDBM413164 ((R)-4-(1-(5-(3,4-dimethylpiperazine-1-carbonyl)pyr...) Show SMILES C[C@@H]1CN(CCN1C)C(=O)c1ccc(nc1)-n1ncc(c1O)-c1cc(F)c(cc1C)C#N |r| Show InChI InChI=1S/C23H23FN6O2/c1-14-8-17(10-25)20(24)9-18(14)19-12-27-30(23(19)32)21-5-4-16(11-26-21)22(31)29-7-6-28(3)15(2)13-29/h4-5,8-9,11-12,15,32H,6-7,13H2,1-3H3/t15-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	3.63	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited US Patent					Assay Description The IC50 values for the PHD2 enzyme (residues 181-417) were determined by mixing increasing amounts of inhibitor with a fixed amount of enzyme (5 nM,...				US Patent US10407409 (2019) BindingDB Entry DOI: 10.7270/Q2D79DR0
					More data for this Ligand-Target Pair
Egl nine homolog 1 [181-417] (Homo sapiens (Human))	BDBM413205 (2-fluoro-4-(5-hydroxy-1-(5-(3-(piperidin-1-yl)azet...) Show SMILES Cc1c(F)c(ccc1-c1cnn(c1O)-c1ccc(cn1)C(=O)N1CC(C1)N1CCCCC1)C#N Show InChI InChI=1S/C25H25FN6O2/c1-16-20(7-5-17(11-27)23(16)26)21-13-29-32(25(21)34)22-8-6-18(12-28-22)24(33)31-14-19(15-31)30-9-3-2-4-10-30/h5-8,12-13,19,34H,2-4,9-10,14-15H2,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	3.72	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited US Patent					Assay Description The IC50 values for the PHD2 enzyme (residues 181-417) were determined by mixing increasing amounts of inhibitor with a fixed amount of enzyme (5 nM,...				US Patent US10407409 (2019) BindingDB Entry DOI: 10.7270/Q2D79DR0
					More data for this Ligand-Target Pair
Egl nine homolog 1 [181-417] (Homo sapiens (Human))	BDBM413246 (4-(5-hydroxy-1-(5-(4-propylpiperazine-1-carbonyl)p...) Show SMILES CCCN1CCN(CC1)C(=O)c1ccc(nc1)-n1ncc(c1O)-c1ccc(cc1C)C#N Show InChI InChI=1S/C24H26N6O2/c1-3-8-28-9-11-29(12-10-28)23(31)19-5-7-22(26-15-19)30-24(32)21(16-27-30)20-6-4-18(14-25)13-17(20)2/h4-7,13,15-16,32H,3,8-12H2,1-2H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	3.89	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited US Patent					Assay Description The IC50 values for the PHD2 enzyme (residues 181-417) were determined by mixing increasing amounts of inhibitor with a fixed amount of enzyme (5 nM,...				US Patent US10407409 (2019) BindingDB Entry DOI: 10.7270/Q2D79DR0
					More data for this Ligand-Target Pair
Egl nine homolog 1 [181-417] (Homo sapiens (Human))	BDBM413011 (6-(4-(4-cyano-2-methylphenyl)-5-hydroxy-1H-pyrazol...) Show SMILES Cc1cc(ccc1-c1cnn(c1O)-c1ccc(cn1)C(=O)NC1CCN(CC(F)(F)F)CC1)C#N Show InChI InChI=1S/C24H23F3N6O2/c1-15-10-16(11-28)2-4-19(15)20-13-30-33(23(20)35)21-5-3-17(12-29-21)22(34)31-18-6-8-32(9-7-18)14-24(25,26)27/h2-5,10,12-13,18,35H,6-9,14H2,1H3,(H,31,34)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	3.89	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited US Patent					Assay Description The IC50 values for the PHD2 enzyme (residues 181-417) were determined by mixing increasing amounts of inhibitor with a fixed amount of enzyme (5 nM,...				US Patent US10407409 (2019) BindingDB Entry DOI: 10.7270/Q2D79DR0
					More data for this Ligand-Target Pair
Egl nine homolog 1 [181-417] (Homo sapiens (Human))	BDBM413121 (4-(1-(5-(3-(dimethylamino)azetidine-1-carbonyl)pyr...) Show SMILES CN(C)C1CN(C1)C(=O)c1ccc(nc1)-n1ncc(c1O)-c1ccc(C#N)c(F)c1C Show InChI InChI=1S/C22H21FN6O2/c1-13-17(6-4-14(8-24)20(13)23)18-10-26-29(22(18)31)19-7-5-15(9-25-19)21(30)28-11-16(12-28)27(2)3/h4-7,9-10,16,31H,11-12H2,1-3H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	3.98	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited US Patent					Assay Description The IC50 values for the PHD2 enzyme (residues 181-417) were determined by mixing increasing amounts of inhibitor with a fixed amount of enzyme (5 nM,...				US Patent US10407409 (2019) BindingDB Entry DOI: 10.7270/Q2D79DR0
					More data for this Ligand-Target Pair
Egl nine homolog 1 [181-417] (Homo sapiens (Human))	BDBM413104 (6-(4-(4-cyano-2-methylphenyl)-5-hydroxy-1H-pyrazol...) Show SMILES Cc1cc(ccc1-c1cnn(c1O)-c1ccc(cn1)C(=O)NCCC1CCCO1)C#N Show InChI InChI=1S/C23H23N5O3/c1-15-11-16(12-24)4-6-19(15)20-14-27-28(23(20)30)21-7-5-17(13-26-21)22(29)25-9-8-18-3-2-10-31-18/h4-7,11,13-14,18,30H,2-3,8-10H2,1H3,(H,25,29)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	3.98	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited US Patent					Assay Description The IC50 values for the PHD2 enzyme (residues 181-417) were determined by mixing increasing amounts of inhibitor with a fixed amount of enzyme (5 nM,...				US Patent US10407409 (2019) BindingDB Entry DOI: 10.7270/Q2D79DR0
					More data for this Ligand-Target Pair
Egl nine homolog 1 [181-417] (Homo sapiens (Human))	BDBM413098 (6-(4-(4-cyano-2-methylphenyl)-5-hydroxy-1H-pyrazol...) Show SMILES Cc1cc(ccc1-c1cnn(c1O)-c1ccc(cn1)C(=O)NC1CC2(COC2)C1)C#N Show InChI InChI=1S/C23H21N5O3/c1-14-6-15(9-24)2-4-18(14)19-11-26-28(22(19)30)20-5-3-16(10-25-20)21(29)27-17-7-23(8-17)12-31-13-23/h2-6,10-11,17,30H,7-8,12-13H2,1H3,(H,27,29)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	3.98	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited US Patent					Assay Description The IC50 values for the PHD2 enzyme (residues 181-417) were determined by mixing increasing amounts of inhibitor with a fixed amount of enzyme (5 nM,...				US Patent US10407409 (2019) BindingDB Entry DOI: 10.7270/Q2D79DR0
					More data for this Ligand-Target Pair
Egl nine homolog 1 [181-417] (Homo sapiens (Human))	BDBM413223 (6-(5-hydroxy-4-(2-methoxypyridin-4-yl)-1H-pyrazol-...) Show SMILES COCC1(CNC(=O)c2ccc(nc2)-n2ncc(c2O)-c2ccnc(OC)c2)CCCC1 Show InChI InChI=1S/C23H27N5O4/c1-31-15-23(8-3-4-9-23)14-26-21(29)17-5-6-19(25-12-17)28-22(30)18(13-27-28)16-7-10-24-20(11-16)32-2/h5-7,10-13,30H,3-4,8-9,14-15H2,1-2H3,(H,26,29)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	3.98	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited US Patent					Assay Description The IC50 values for the PHD2 enzyme (residues 181-417) were determined by mixing increasing amounts of inhibitor with a fixed amount of enzyme (5 nM,...				US Patent US10407409 (2019) BindingDB Entry DOI: 10.7270/Q2D79DR0
					More data for this Ligand-Target Pair
Egl nine homolog 1 [181-417] (Homo sapiens (Human))	BDBM413221 ((R)-4-(1-(5-(4-ethyl-3-methylpiperazine-1-carbonyl...) Show SMILES CCN1CCN(C[C@H]1C)C(=O)c1ccc(nc1)-n1ncc(c1O)-c1ccc(C#N)c(F)c1C |r| Show InChI InChI=1S/C24H25FN6O2/c1-4-29-9-10-30(14-15(29)2)23(32)18-6-8-21(27-12-18)31-24(33)20(13-28-31)19-7-5-17(11-26)22(25)16(19)3/h5-8,12-13,15,33H,4,9-10,14H2,1-3H3/t15-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	3.98	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited US Patent					Assay Description The IC50 values for the PHD2 enzyme (residues 181-417) were determined by mixing increasing amounts of inhibitor with a fixed amount of enzyme (5 nM,...				US Patent US10407409 (2019) BindingDB Entry DOI: 10.7270/Q2D79DR0
					More data for this Ligand-Target Pair
Egl nine homolog 1 [181-417] (Homo sapiens (Human))	BDBM413148 (6-(4-(4-cyano-2-methylphenyl)-5-hydroxy-1H-pyrazol...) Show SMILES CNC(=O)c1ccc(nc1)-n1ncc(c1O)-c1ccc(cc1C)C#N Show InChI InChI=1S/C18H15N5O2/c1-11-7-12(8-19)3-5-14(11)15-10-22-23(18(15)25)16-6-4-13(9-21-16)17(24)20-2/h3-7,9-10,25H,1-2H3,(H,20,24)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	3.98	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited US Patent					Assay Description The IC50 values for the PHD2 enzyme (residues 181-417) were determined by mixing increasing amounts of inhibitor with a fixed amount of enzyme (5 nM,...				US Patent US10407409 (2019) BindingDB Entry DOI: 10.7270/Q2D79DR0
					More data for this Ligand-Target Pair
Microtubule-associated protein 2 (Homo sapiens (Human))	BDBM50167926 (CHEMBL3798871) Show SMILES OCCNC(=O)c1ccc(c(F)c1)-c1cc(cc2[nH]ncc12)C(F)(F)F Show InChI InChI=1S/C17H13F4N3O2/c18-14-5-9(16(26)22-3-4-25)1-2-11(14)12-6-10(17(19,20)21)7-15-13(12)8-23-24-15/h1-2,5-8,25H,3-4H2,(H,22,26)(H,23,24)	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Takeda California Curated by ChEMBL					Assay Description Reversal inhibition of full length recombinant human MetAP2 expressed in baculovirus infected insect Sf9 cells using Met-AMC as substrate measured fo...				Bioorg Med Chem Lett 26: 2774-2778 (2016) Article DOI: 10.1016/j.bmcl.2016.04.073 BindingDB Entry DOI: 10.7270/Q2DF6T4T
					More data for this Ligand-Target Pair
Microtubule-associated protein 2 (Homo sapiens (Human))	BDBM50167915 (CHEMBL3798727) Show SMILES FC(F)(F)c1cc(-c2ccc3nccn3c2)c2cn[nH]c2c1 Show InChI InChI=1S/C15H9F3N4/c16-15(17,18)10-5-11(12-7-20-21-13(12)6-10)9-1-2-14-19-3-4-22(14)8-9/h1-8H,(H,20,21)	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Takeda California Curated by ChEMBL					Assay Description Reversal inhibition of full length recombinant human MetAP2 expressed in baculovirus infected insect Sf9 cells using Met-AMC as substrate measured fo...				Bioorg Med Chem Lett 26: 2774-2778 (2016) Article DOI: 10.1016/j.bmcl.2016.04.073 BindingDB Entry DOI: 10.7270/Q2DF6T4T
					More data for this Ligand-Target Pair

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