Compile Data Set for Download or QSAR

Found 12 hits with Last Name = 'mnich' and Initial = 'sj'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM19440 (1-[3-(4-chlorophenyl)-4-(pyridin-4-yl)-1H-pyrazol-...) Show SMILES CC1CN(CC(C)N1)c1[nH]nc(c1-c1ccncc1)-c1ccc(Cl)cc1 Show InChI InChI=1S/C20H22ClN5/c1-13-11-26(12-14(2)23-13)20-18(15-7-9-22-10-8-15)19(24-25-20)16-3-5-17(21)6-4-16/h3-10,13-14,23H,11-12H2,1-2H3,(H,24,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	12	n/a	n/a	n/a	n/a	7.5	30
Pfizer					Assay Description Kinase activity was assayed in reaction buffer containing substrate, enzyme, and inhibitor in the presence of 50 uM ATP/[gamma-33P] ATP. 33P incorpor...				J Med Chem 50: 5712-9 (2007) Article DOI: 10.1021/jm0611915 BindingDB Entry DOI: 10.7270/Q20G3HD5
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM19439 (1-[3-(4-chlorophenyl)-4-(pyridin-4-yl)-1H-pyrazol-...) Show SMILES CC1CN(CCN1)c1[nH]nc(c1-c1ccncc1)-c1ccc(Cl)cc1 Show InChI InChI=1S/C19H20ClN5/c1-13-12-25(11-10-22-13)19-17(14-6-8-21-9-7-14)18(23-24-19)15-2-4-16(20)5-3-15/h2-9,13,22H,10-12H2,1H3,(H,23,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	16	n/a	n/a	n/a	n/a	7.5	30
Pfizer					Assay Description Kinase activity was assayed in reaction buffer containing substrate, enzyme, and inhibitor in the presence of 50 uM ATP/[gamma-33P] ATP. 33P incorpor...				J Med Chem 50: 5712-9 (2007) Article DOI: 10.1021/jm0611915 BindingDB Entry DOI: 10.7270/Q20G3HD5
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM19435 (1-[3-(4-chlorophenyl)-4-(pyridin-4-yl)-1H-pyrazol-...) Show SMILES Clc1ccc(cc1)-c1n[nH]c(N2CCCC3CCCCC23)c1-c1ccncc1 |w:19.20,15.16| Show InChI InChI=1S/C23H25ClN4/c24-19-9-7-18(8-10-19)22-21(17-11-13-25-14-12-17)23(27-26-22)28-15-3-5-16-4-1-2-6-20(16)28/h7-14,16,20H,1-6,15H2,(H,26,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	40	n/a	n/a	n/a	n/a	7.5	30
Pfizer					Assay Description Kinase activity was assayed in reaction buffer containing substrate, enzyme, and inhibitor in the presence of 50 uM ATP/[gamma-33P] ATP. 33P incorpor...				J Med Chem 50: 5712-9 (2007) Article DOI: 10.1021/jm0611915 BindingDB Entry DOI: 10.7270/Q20G3HD5
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM19430 (1-[3-(4-chlorophenyl)-4-(pyridin-4-yl)-1H-pyrazol-...) Show SMILES CN1CCN(CC1)c1[nH]nc(c1-c1ccncc1)-c1ccc(Cl)cc1 Show InChI InChI=1S/C19H20ClN5/c1-24-10-12-25(13-11-24)19-17(14-6-8-21-9-7-14)18(22-23-19)15-2-4-16(20)5-3-15/h2-9H,10-13H2,1H3,(H,22,23)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	50	n/a	n/a	n/a	n/a	7.5	30
Pfizer					Assay Description Kinase activity was assayed in reaction buffer containing substrate, enzyme, and inhibitor in the presence of 50 uM ATP/[gamma-33P] ATP. 33P incorpor...				J Med Chem 50: 5712-9 (2007) Article DOI: 10.1021/jm0611915 BindingDB Entry DOI: 10.7270/Q20G3HD5
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM19438 (4-{5-[(8aS)-octahydropyrrolo[1,2-a]piperazin-2-yl]...) Show SMILES Clc1ccc(cc1)-c1n[nH]c(N2CCN3CCC[C@H]3C2)c1-c1ccncc1 |r| Show InChI InChI=1S/C21H22ClN5/c22-17-5-3-16(4-6-17)20-19(15-7-9-23-10-8-15)21(25-24-20)27-13-12-26-11-1-2-18(26)14-27/h3-10,18H,1-2,11-14H2,(H,24,25)/t18-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	62	n/a	n/a	n/a	n/a	7.5	30
Pfizer					Assay Description Kinase activity was assayed in reaction buffer containing substrate, enzyme, and inhibitor in the presence of 50 uM ATP/[gamma-33P] ATP. 33P incorpor...				J Med Chem 50: 5712-9 (2007) Article DOI: 10.1021/jm0611915 BindingDB Entry DOI: 10.7270/Q20G3HD5
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM19437 (1-[3-(4-chlorophenyl)-4-(pyridin-4-yl)-1H-pyrazol-...) Show SMILES OC1CCN(CC1)c1[nH]nc(c1-c1ccncc1)-c1ccc(Cl)cc1 Show InChI InChI=1S/C19H19ClN4O/c20-15-3-1-14(2-4-15)18-17(13-5-9-21-10-6-13)19(23-22-18)24-11-7-16(25)8-12-24/h1-6,9-10,16,25H,7-8,11-12H2,(H,22,23)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	110	n/a	n/a	n/a	n/a	7.5	30
Pfizer					Assay Description Kinase activity was assayed in reaction buffer containing substrate, enzyme, and inhibitor in the presence of 50 uM ATP/[gamma-33P] ATP. 33P incorpor...				J Med Chem 50: 5712-9 (2007) Article DOI: 10.1021/jm0611915 BindingDB Entry DOI: 10.7270/Q20G3HD5
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM19431 (4-[3-(4-chlorophenyl)-5-(3,5-dimethylpiperidin-1-y...) Show SMILES CC1CC(C)CN(C1)c1[nH]nc(c1-c1ccncc1)-c1ccc(Cl)cc1 Show InChI InChI=1S/C21H23ClN4/c1-14-11-15(2)13-26(12-14)21-19(16-7-9-23-10-8-16)20(24-25-21)17-3-5-18(22)6-4-17/h3-10,14-15H,11-13H2,1-2H3,(H,24,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	130	n/a	n/a	n/a	n/a	7.5	30
Pfizer					Assay Description Kinase activity was assayed in reaction buffer containing substrate, enzyme, and inhibitor in the presence of 50 uM ATP/[gamma-33P] ATP. 33P incorpor...				J Med Chem 50: 5712-9 (2007) Article DOI: 10.1021/jm0611915 BindingDB Entry DOI: 10.7270/Q20G3HD5
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM19432 (4-[3-(4-chlorophenyl)-5-(4-methylpiperidin-1-yl)-1...) Show SMILES CC1CCN(CC1)c1[nH]nc(c1-c1ccncc1)-c1ccc(Cl)cc1 Show InChI InChI=1S/C20H21ClN4/c1-14-8-12-25(13-9-14)20-18(15-6-10-22-11-7-15)19(23-24-20)16-2-4-17(21)5-3-16/h2-7,10-11,14H,8-9,12-13H2,1H3,(H,23,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	130	n/a	n/a	n/a	n/a	7.5	30
Pfizer					Assay Description Kinase activity was assayed in reaction buffer containing substrate, enzyme, and inhibitor in the presence of 50 uM ATP/[gamma-33P] ATP. 33P incorpor...				J Med Chem 50: 5712-9 (2007) Article DOI: 10.1021/jm0611915 BindingDB Entry DOI: 10.7270/Q20G3HD5
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM19436 (1-[3-(4-chlorophenyl)-4-(pyridin-4-yl)-1H-pyrazol-...) Show SMILES OC1CCCN(C1)c1[nH]nc(c1-c1ccncc1)-c1ccc(Cl)cc1 Show InChI InChI=1S/C19H19ClN4O/c20-15-5-3-14(4-6-15)18-17(13-7-9-21-10-8-13)19(23-22-18)24-11-1-2-16(25)12-24/h3-10,16,25H,1-2,11-12H2,(H,22,23)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	190	n/a	n/a	n/a	n/a	7.5	30
Pfizer					Assay Description Kinase activity was assayed in reaction buffer containing substrate, enzyme, and inhibitor in the presence of 50 uM ATP/[gamma-33P] ATP. 33P incorpor...				J Med Chem 50: 5712-9 (2007) Article DOI: 10.1021/jm0611915 BindingDB Entry DOI: 10.7270/Q20G3HD5
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM19434 (2-[3-(4-chlorophenyl)-4-(pyridin-4-yl)-1H-pyrazol-...) Show SMILES Clc1ccc(cc1)-c1n[nH]c(N2CCc3ccccc3C2)c1-c1ccncc1 Show InChI InChI=1S/C23H19ClN4/c24-20-7-5-18(6-8-20)22-21(17-9-12-25-13-10-17)23(27-26-22)28-14-11-16-3-1-2-4-19(16)15-28/h1-10,12-13H,11,14-15H2,(H,26,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	190	n/a	n/a	n/a	n/a	7.5	30
Pfizer					Assay Description Kinase activity was assayed in reaction buffer containing substrate, enzyme, and inhibitor in the presence of 50 uM ATP/[gamma-33P] ATP. 33P incorpor...				J Med Chem 50: 5712-9 (2007) Article DOI: 10.1021/jm0611915 BindingDB Entry DOI: 10.7270/Q20G3HD5
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM19433 (2-[3-(4-chlorophenyl)-4-(pyridin-4-yl)-1H-pyrazol-...) Show SMILES Clc1ccc(cc1)-c1n[nH]c(N2CCC3CCCCC3C2)c1-c1ccncc1 |w:14.15,19.19| Show InChI InChI=1S/C23H25ClN4/c24-20-7-5-18(6-8-20)22-21(17-9-12-25-13-10-17)23(27-26-22)28-14-11-16-3-1-2-4-19(16)15-28/h5-10,12-13,16,19H,1-4,11,14-15H2,(H,26,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	260	n/a	n/a	n/a	n/a	7.5	30
Pfizer					Assay Description Kinase activity was assayed in reaction buffer containing substrate, enzyme, and inhibitor in the presence of 50 uM ATP/[gamma-33P] ATP. 33P incorpor...				J Med Chem 50: 5712-9 (2007) Article DOI: 10.1021/jm0611915 BindingDB Entry DOI: 10.7270/Q20G3HD5
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM19429 (4-[3-(4-fluorophenyl)-1H-pyrazol-4-yl]pyridine | S...) Show SMILES Fc1ccc(cc1)-c1n[nH]cc1-c1ccncc1 Show InChI InChI=1S/C14H10FN3/c15-12-3-1-11(2-4-12)14-13(9-17-18-14)10-5-7-16-8-6-10/h1-9H,(H,17,18)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	DrugBank MMDB PC cid PC sid PDB UniChem Patents	DrugBank PDB Article PubMed	n/a	n/a	600	n/a	n/a	n/a	n/a	7.5	30
Pfizer					Assay Description Kinase activity was assayed in reaction buffer containing substrate, enzyme, and inhibitor in the presence of 50 uM ATP/[gamma-33P] ATP. 33P incorpor...				J Med Chem 50: 5712-9 (2007) Article DOI: 10.1021/jm0611915 BindingDB Entry DOI: 10.7270/Q20G3HD5
					More data for this Ligand-Target Pair				3D Structure (crystal)