Compile Data Set for Download or QSAR

Found 867 hits with Last Name = 'morriello' and Initial = 'gj'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cGMP-dependent 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50576278 (CHEMBL4863002) Show SMILES C[C@@H](c1nn(CCF)c2c1nc(C)[nH]c2=O)c1ccc(c(F)c1)C(F)(F)F |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	0.920	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human PDE2				Citation and Details Article DOI: 10.1016/j.bmcl.2021.128082 BindingDB Entry DOI: 10.7270/Q2KK9GNG
					More data for this Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50576275 (CHEMBL4873599) Show SMILES C[C@@H](c1nn(CCO)c2c1nc(C)[nH]c2=O)c1ccc(c(F)c1)C(F)(F)F |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	1.10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human PDE2				Citation and Details Article DOI: 10.1016/j.bmcl.2021.128082 BindingDB Entry DOI: 10.7270/Q2KK9GNG
					More data for this Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50576279 (CHEMBL4871796) Show SMILES C[C@@H](c1nn(CCF)c2c1nc(C)[nH]c2=O)c1ccc(cc1)C(C)(C)C |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	1.30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human PDE2				Citation and Details Article DOI: 10.1016/j.bmcl.2021.128082 BindingDB Entry DOI: 10.7270/Q2KK9GNG
					More data for this Ligand-Target Pair
Phosphodiesterase (Macaca mulatta (Rhesus macaque))	BDBM442759 (6-Chloro-N,1-dimethyl-N-{1-[4-(trifluoromethyl)phe...) Show SMILES CN(c1nc(Cl)nc2n(C)ncc12)C1(CC1)c1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C17H15ClF3N5/c1-25(13-12-9-22-26(2)14(12)24-15(18)23-13)16(7-8-16)10-3-5-11(6-4-10)17(19,20)21/h3-6,9H,7-8H2,1-2H3	PDB UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	1.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...				US Patent US10647727 (2020) BindingDB Entry DOI: 10.7270/Q2KS6VK2
					More data for this Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50576271 (CHEMBL4877091) Show SMILES C[C@@H](c1nn(CCO)c2c1nc(C)[nH]c2=O)c1ccc(cc1)C(F)(F)F |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	1.70	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human PDE2				Citation and Details Article DOI: 10.1016/j.bmcl.2021.128082 BindingDB Entry DOI: 10.7270/Q2KK9GNG
					More data for this Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM385964 (US10287293, Example 13 | US10287293, Example 14) Show SMILES C[C@@H](c1nn(CCF)c2c1nc(C)[nH]c2=O)c1ccc(cc1)C(F)(F)F |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	1.80	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human PDE2				Citation and Details Article DOI: 10.1016/j.bmcl.2021.128082 BindingDB Entry DOI: 10.7270/Q2KK9GNG
					More data for this Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50576277 (CHEMBL4878348) Show SMILES C[C@@H](c1nn(CCO)c2c1nc(C)[nH]c2=O)c1ccc(cc1)C(C)(C)C |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	2.60	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human PDE2				Citation and Details Article DOI: 10.1016/j.bmcl.2021.128082 BindingDB Entry DOI: 10.7270/Q2KK9GNG
					More data for this Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50452209 (CHEMBL4207777 | US10647727, Example 9) Show SMILES Cn1ncc2c(NC3(CC3)c3ccc(cc3)C(F)(F)F)nc(Cl)nc12 Show InChI InChI=1S/C16H13ClF3N5/c1-25-13-11(8-21-25)12(22-14(17)23-13)24-15(6-7-15)9-2-4-10(5-3-9)16(18,19)20/h2-5,8H,6-7H2,1H3,(H,22,23,24)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	3.40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...				US Patent US10647727 (2020) BindingDB Entry DOI: 10.7270/Q2KS6VK2
					More data for this Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM442759 (6-Chloro-N,1-dimethyl-N-{1-[4-(trifluoromethyl)phe...) Show SMILES CN(c1nc(Cl)nc2n(C)ncc12)C1(CC1)c1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C17H15ClF3N5/c1-25(13-12-9-22-26(2)14(12)24-15(18)23-13)16(7-8-16)10-3-5-11(6-4-10)17(19,20)21/h3-6,9H,7-8H2,1-2H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	3.80	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...				US Patent US10647727 (2020) BindingDB Entry DOI: 10.7270/Q2KS6VK2
					More data for this Ligand-Target Pair
Phosphodiesterase (Macaca mulatta (Rhesus macaque))	BDBM50452209 (CHEMBL4207777 | US10647727, Example 9) Show SMILES Cn1ncc2c(NC3(CC3)c3ccc(cc3)C(F)(F)F)nc(Cl)nc12 Show InChI InChI=1S/C16H13ClF3N5/c1-25-13-11(8-21-25)12(22-14(17)23-13)24-15(6-7-15)9-2-4-10(5-3-9)16(18,19)20/h2-5,8H,6-7H2,1H3,(H,22,23,24)	PDB UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	4.30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...				US Patent US10647727 (2020) BindingDB Entry DOI: 10.7270/Q2KS6VK2
					More data for this Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM442769 (N,1,6-Trimethyl-N-{1-[4-(trifluoromethyl)phenyl]cy...) Show SMILES CN(c1nc(C)nc2n(C)ncc12)C1(CC1)c1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C18H18F3N5/c1-11-23-15(14-10-22-26(3)16(14)24-11)25(2)17(8-9-17)12-4-6-13(7-5-12)18(19,20)21/h4-7,10H,8-9H2,1-3H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	4.90	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...				US Patent US10647727 (2020) BindingDB Entry DOI: 10.7270/Q2KS6VK2
					More data for this Ligand-Target Pair
Phosphodiesterase (Macaca mulatta (Rhesus macaque))	BDBM50452200 (CHEMBL4212416 | US10647727, Example 20) Show SMILES Cc1nc(NC2(CC2)c2ccc(cc2)C(F)(F)F)c2cnn(C)c2n1 Show InChI InChI=1S/C17H16F3N5/c1-10-22-14(13-9-21-25(2)15(13)23-10)24-16(7-8-16)11-3-5-12(6-4-11)17(18,19)20/h3-6,9H,7-8H2,1-2H3,(H,22,23,24)	PDB UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	5.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...				US Patent US10647727 (2020) BindingDB Entry DOI: 10.7270/Q2KS6VK2
					More data for this Ligand-Target Pair
Phosphodiesterase (Macaca mulatta (Rhesus macaque))	BDBM442759 (6-Chloro-N,1-dimethyl-N-{1-[4-(trifluoromethyl)phe...) Show SMILES CN(c1nc(Cl)nc2n(C)ncc12)C1(CC1)c1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C17H15ClF3N5/c1-25(13-12-9-22-26(2)14(12)24-15(18)23-13)16(7-8-16)10-3-5-11(6-4-10)17(19,20)21/h3-6,9H,7-8H2,1-2H3	PDB UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	6	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...				US Patent US10647727 (2020) BindingDB Entry DOI: 10.7270/Q2KS6VK2
					More data for this Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50452200 (CHEMBL4212416 | US10647727, Example 20) Show SMILES Cc1nc(NC2(CC2)c2ccc(cc2)C(F)(F)F)c2cnn(C)c2n1 Show InChI InChI=1S/C17H16F3N5/c1-10-22-14(13-9-21-25(2)15(13)23-10)24-16(7-8-16)11-3-5-12(6-4-11)17(18,19)20/h3-6,9H,7-8H2,1-2H3,(H,22,23,24)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	6.10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...				US Patent US10647727 (2020) BindingDB Entry DOI: 10.7270/Q2KS6VK2
					More data for this Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM385962 (US10287293, Example 11 | US10287293, Example 12) Show SMILES C[C@@H](c1nn(CC(F)(F)F)c2c1nc(C)[nH]c2=O)c1ccc(cc1)C(F)(F)F |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	7	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human PDE2				Citation and Details Article DOI: 10.1016/j.bmcl.2021.128082 BindingDB Entry DOI: 10.7270/Q2KK9GNG
					More data for this Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50452200 (CHEMBL4212416 | US10647727, Example 20) Show SMILES Cc1nc(NC2(CC2)c2ccc(cc2)C(F)(F)F)c2cnn(C)c2n1 Show InChI InChI=1S/C17H16F3N5/c1-10-22-14(13-9-21-25(2)15(13)23-10)24-16(7-8-16)11-3-5-12(6-4-11)17(18,19)20/h3-6,9H,7-8H2,1-2H3,(H,22,23,24)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	8.40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...				US Patent US10647727 (2020) BindingDB Entry DOI: 10.7270/Q2KS6VK2
					More data for this Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM385952 (US10287293, Example 1 | US10287293, Example 2) Show SMILES C[C@@H](c1n[nH]c2c1nc(C)[nH]c2=O)c1ccc(cc1)C(F)(F)F |r| Show InChI InChI=1S/C15H11F3N4O/c1-7(9-3-5-10(6-4-9)15(16,17)18)11-12-13(22-21-11)14(23)20-8(2)19-12/h3-7H,1-2H3/t7-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	15	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human PDE2				Citation and Details Article DOI: 10.1016/j.bmcl.2021.128082 BindingDB Entry DOI: 10.7270/Q2KK9GNG
					More data for this Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM442766 (1,6-Dimethyl-N- (1-{4- [(trifluoromethyl)- sulfany...) Show SMILES Cc1nc(NC2(CC2)c2ccc(SC(F)(F)F)cc2)c2cnn(C)c2n1 Show InChI InChI=1S/C17H16F3N5S/c1-10-22-14(13-9-21-25(2)15(13)23-10)24-16(7-8-16)11-3-5-12(6-4-11)26-17(18,19)20/h3-6,9H,7-8H2,1-2H3,(H,22,23,24)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	16	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...				US Patent US10647727 (2020) BindingDB Entry DOI: 10.7270/Q2KS6VK2
					More data for this Ligand-Target Pair
Phosphodiesterase (Macaca mulatta (Rhesus macaque))	BDBM442766 (1,6-Dimethyl-N- (1-{4- [(trifluoromethyl)- sulfany...) Show SMILES Cc1nc(NC2(CC2)c2ccc(SC(F)(F)F)cc2)c2cnn(C)c2n1 Show InChI InChI=1S/C17H16F3N5S/c1-10-22-14(13-9-21-25(2)15(13)23-10)24-16(7-8-16)11-3-5-12(6-4-11)26-17(18,19)20/h3-6,9H,7-8H2,1-2H3,(H,22,23,24)	PDB UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...				US Patent US10647727 (2020) BindingDB Entry DOI: 10.7270/Q2KS6VK2
					More data for this Ligand-Target Pair
Phosphodiesterase (Macaca mulatta (Rhesus macaque))	BDBM50452216 (CHEMBL4215537 | US10647727, Example 13) Show SMILES Cn1ncc2c(NC3(CC3)c3ccc(cc3)C(F)(F)F)nc(nc12)C1CC1 Show InChI InChI=1S/C19H18F3N5/c1-27-17-14(10-23-27)16(24-15(25-17)11-2-3-11)26-18(8-9-18)12-4-6-13(7-5-12)19(20,21)22/h4-7,10-11H,2-3,8-9H2,1H3,(H,24,25,26)	PDB UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...				US Patent US10647727 (2020) BindingDB Entry DOI: 10.7270/Q2KS6VK2
					More data for this Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50576268 (CHEMBL4853336) Show SMILES CC(c1n[nH]c2c1nc(C)[nH]c2=O)c1ccc(cc1)C(F)(F)F Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	27	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human PDE2				Citation and Details Article DOI: 10.1016/j.bmcl.2021.128082 BindingDB Entry DOI: 10.7270/Q2KK9GNG
					More data for this Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50576272 (CHEMBL4867001) Show SMILES C[C@H](c1nn(CCF)c2c1nc(C)[nH]c2=O)c1ccc(cc1)C(F)(F)F |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	27	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human PDE2				Citation and Details Article DOI: 10.1016/j.bmcl.2021.128082 BindingDB Entry DOI: 10.7270/Q2KK9GNG
					More data for this Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM442767 (N-{1-[2-Fluoro-4- (trifluoromethyl)- phenyl]cyclo-...) Show SMILES Cc1nc(NC2(CC2)c2ccc(cc2F)C(F)(F)F)c2cnn(C)c2n1 Show InChI InChI=1S/C17H15F4N5/c1-9-23-14(11-8-22-26(2)15(11)24-9)25-16(5-6-16)12-4-3-10(7-13(12)18)17(19,20)21/h3-4,7-8H,5-6H2,1-2H3,(H,23,24,25)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	29	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...				US Patent US10647727 (2020) BindingDB Entry DOI: 10.7270/Q2KS6VK2
					More data for this Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM442773 (1,6-Dimethyl-4-({1-[4-(trifluoromethyl)phenyl]cycl...) Show SMILES Cc1nc(OC2(CC2)c2ccc(cc2)C(F)(F)F)c2cnn(C)c2n1 Show InChI InChI=1S/C17H15F3N4O/c1-10-22-14-13(9-21-24(14)2)15(23-10)25-16(7-8-16)11-3-5-12(6-4-11)17(18,19)20/h3-6,9H,7-8H2,1-2H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	32	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...				US Patent US10647727 (2020) BindingDB Entry DOI: 10.7270/Q2KS6VK2
					More data for this Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM442765 (N-{1-[3-Fluoro-4- (trifluoromethyl)- phenyl]cyclo-...) Show SMILES Cc1nc(NC2(CC2)c2ccc(OC(F)(F)F)c(F)c2)c2cnn(C)c2n1 Show InChI InChI=1S/C17H15F4N5O/c1-9-23-14(11-8-22-26(2)15(11)24-9)25-16(5-6-16)10-3-4-13(12(18)7-10)27-17(19,20)21/h3-4,7-8H,5-6H2,1-2H3,(H,23,24,25)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	35	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...				US Patent US10647727 (2020) BindingDB Entry DOI: 10.7270/Q2KS6VK2
					More data for this Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM442772 (1-Methyl-4-{1-[4-(trifluoromethyl)phenyl]cycloprop...) Show SMILES Cn1ncc2c(NC3(CC3)c3ccc(cc3)C(F)(F)F)nc(nc12)C#N Show InChI InChI=1S/C17H13F3N6/c1-26-15-12(9-22-26)14(23-13(8-21)24-15)25-16(6-7-16)10-2-4-11(5-3-10)17(18,19)20/h2-5,9H,6-7H2,1H3,(H,23,24,25)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	39	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...				US Patent US10647727 (2020) BindingDB Entry DOI: 10.7270/Q2KS6VK2
					More data for this Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM442770 (N,1,6-Trimethyl-N-(1-{4-[(trifluoromethyl)sulfanyl...) Show SMILES CN(c1nc(C)nc2n(C)ncc12)C1(CC1)c1ccc(SC(F)(F)F)cc1 Show InChI InChI=1S/C18H18F3N5S/c1-11-23-15(14-10-22-26(3)16(14)24-11)25(2)17(8-9-17)12-4-6-13(7-5-12)27-18(19,20)21/h4-7,10H,8-9H2,1-3H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...				US Patent US10647727 (2020) BindingDB Entry DOI: 10.7270/Q2KS6VK2
					More data for this Ligand-Target Pair
Phosphodiesterase (Macaca mulatta (Rhesus macaque))	BDBM442772 (1-Methyl-4-{1-[4-(trifluoromethyl)phenyl]cycloprop...) Show SMILES Cn1ncc2c(NC3(CC3)c3ccc(cc3)C(F)(F)F)nc(nc12)C#N Show InChI InChI=1S/C17H13F3N6/c1-26-15-12(9-22-26)14(23-13(8-21)24-15)25-16(6-7-16)10-2-4-11(5-3-10)17(18,19)20/h2-5,9H,6-7H2,1H3,(H,23,24,25)	PDB UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	47	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...				US Patent US10647727 (2020) BindingDB Entry DOI: 10.7270/Q2KS6VK2
					More data for this Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM442775 ((R)—N-(1-(3-Fluoro-4-(trifluoromethyl)phenyl)-2,2-...) Show SMILES Cc1cc(N[C@@H](c2ccc(c(F)c2)C(F)(F)F)C(C)(C)C)n2ccnc2n1 |r| Show InChI InChI=1S/C19H20F4N4/c1-11-9-15(27-8-7-24-17(27)25-11)26-16(18(2,3)4)12-5-6-13(14(20)10-12)19(21,22)23/h5-10,16,26H,1-4H3/t16-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	51	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...				US Patent US10647727 (2020) BindingDB Entry DOI: 10.7270/Q2KS6VK2
					More data for this Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50452216 (CHEMBL4215537 | US10647727, Example 13) Show SMILES Cn1ncc2c(NC3(CC3)c3ccc(cc3)C(F)(F)F)nc(nc12)C1CC1 Show InChI InChI=1S/C19H18F3N5/c1-27-17-14(10-23-27)16(24-15(25-17)11-2-3-11)26-18(8-9-18)12-4-6-13(7-5-12)19(20,21)22/h4-7,10-11H,2-3,8-9H2,1H3,(H,24,25,26)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	55	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...				US Patent US10647727 (2020) BindingDB Entry DOI: 10.7270/Q2KS6VK2
					More data for this Ligand-Target Pair
Phosphodiesterase (Macaca mulatta (Rhesus macaque))	BDBM442765 (N-{1-[3-Fluoro-4- (trifluoromethyl)- phenyl]cyclo-...) Show SMILES Cc1nc(NC2(CC2)c2ccc(OC(F)(F)F)c(F)c2)c2cnn(C)c2n1 Show InChI InChI=1S/C17H15F4N5O/c1-9-23-14(11-8-22-26(2)15(11)24-9)25-16(5-6-16)10-3-4-13(12(18)7-10)27-17(19,20)21/h3-4,7-8H,5-6H2,1-2H3,(H,23,24,25)	PDB UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	55	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...				US Patent US10647727 (2020) BindingDB Entry DOI: 10.7270/Q2KS6VK2
					More data for this Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM442774 (N-(1-(3-Fluoro-4-(trifluoromethyl)phenyl)cycloprop...) Show SMILES Cc1cc(OC2(CC2)c2ccc(c(F)c2)C(F)(F)F)n2ccnc2n1 Show InChI InChI=1S/C17H13F4N3O/c1-10-8-14(24-7-6-22-15(24)23-10)25-16(4-5-16)11-2-3-12(13(18)9-11)17(19,20)21/h2-3,6-9H,4-5H2,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	55	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...				US Patent US10647727 (2020) BindingDB Entry DOI: 10.7270/Q2KS6VK2
					More data for this Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM442756 (6-Chloro-N,1-dimethyl-N-{(1R)-1-[4-(trifluoromethy...) Show SMILES C[C@@H](N(C)c1nc(Cl)nc2n(C)ncc12)c1ccc(cc1)C(F)(F)F |r| Show InChI InChI=1S/C16H15ClF3N5/c1-9(10-4-6-11(7-5-10)16(18,19)20)24(2)13-12-8-21-25(3)14(12)23-15(17)22-13/h4-9H,1-3H3/t9-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	65	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...				US Patent US10647727 (2020) BindingDB Entry DOI: 10.7270/Q2KS6VK2
					More data for this Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM385954 (US10287293, Example 3 | US10287293, Example 4) Show SMILES C[C@H](c1nn(CCO)c2c1nc(C)[nH]c2=O)c1ccc(cc1)C(F)(F)F |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	65	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human PDE2				Citation and Details Article DOI: 10.1016/j.bmcl.2021.128082 BindingDB Entry DOI: 10.7270/Q2KK9GNG
					More data for this Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM442761 (1-Methyl-6-(trifluoromethyl)-N-(1-(4-(trifluoromet...) Show SMILES Cn1ncc2c(NC3(CC3)c3ccc(cc3)C(F)(F)F)nc(nc12)C(F)(F)F Show InChI InChI=1S/C17H13F6N5/c1-28-13-11(8-24-28)12(25-14(26-13)17(21,22)23)27-15(6-7-15)9-2-4-10(5-3-9)16(18,19)20/h2-5,8H,6-7H2,1H3,(H,25,26,27)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	67	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...				US Patent US10647727 (2020) BindingDB Entry DOI: 10.7270/Q2KS6VK2
					More data for this Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM385976 (US10287293, Example 25) Show SMILES CC(c1nn(C)c2c1nc(C)[nH]c2=O)c1ccc(cc1)C(F)(F)F Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	70	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human PDE2				Citation and Details Article DOI: 10.1016/j.bmcl.2021.128082 BindingDB Entry DOI: 10.7270/Q2KK9GNG
					More data for this Ligand-Target Pair
Phosphodiesterase (Macaca mulatta (Rhesus macaque))	BDBM50452216 (CHEMBL4215537 | US10647727, Example 13) Show SMILES Cn1ncc2c(NC3(CC3)c3ccc(cc3)C(F)(F)F)nc(nc12)C1CC1 Show InChI InChI=1S/C19H18F3N5/c1-27-17-14(10-23-27)16(24-15(25-17)11-2-3-11)26-18(8-9-18)12-4-6-13(7-5-12)19(20,21)22/h4-7,10-11H,2-3,8-9H2,1H3,(H,24,25,26)	PDB UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	72	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...				US Patent US10647727 (2020) BindingDB Entry DOI: 10.7270/Q2KS6VK2
					More data for this Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM442771 (N-{1-[3-Fluoro-4-(trifluoromethyl)phenyl]cycloprop...) Show SMILES Cc1nc(NC2(CC2)c2ccc(c(F)c2)C(F)(F)F)c2cnn(CC(F)(F)F)c2n1 Show InChI InChI=1S/C18H14F7N5/c1-9-27-14(11-7-26-30(15(11)28-9)8-17(20,21)22)29-16(4-5-16)10-2-3-12(13(19)6-10)18(23,24)25/h2-3,6-7H,4-5,8H2,1H3,(H,27,28,29)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	76	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...				US Patent US10647727 (2020) BindingDB Entry DOI: 10.7270/Q2KS6VK2
					More data for this Ligand-Target Pair
Phosphodiesterase (Macaca mulatta (Rhesus macaque))	BDBM442761 (1-Methyl-6-(trifluoromethyl)-N-(1-(4-(trifluoromet...) Show SMILES Cn1ncc2c(NC3(CC3)c3ccc(cc3)C(F)(F)F)nc(nc12)C(F)(F)F Show InChI InChI=1S/C17H13F6N5/c1-28-13-11(8-24-28)12(25-14(26-13)17(21,22)23)27-15(6-7-15)9-2-4-10(5-3-9)16(18,19)20/h2-5,8H,6-7H2,1H3,(H,25,26,27)	PDB UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	80	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...				US Patent US10647727 (2020) BindingDB Entry DOI: 10.7270/Q2KS6VK2
					More data for this Ligand-Target Pair
Phosphodiesterase (Macaca mulatta (Rhesus macaque))	BDBM442771 (N-{1-[3-Fluoro-4-(trifluoromethyl)phenyl]cycloprop...) Show SMILES Cc1nc(NC2(CC2)c2ccc(c(F)c2)C(F)(F)F)c2cnn(CC(F)(F)F)c2n1 Show InChI InChI=1S/C18H14F7N5/c1-9-27-14(11-7-26-30(15(11)28-9)8-17(20,21)22)29-16(4-5-16)10-2-3-12(13(19)6-10)18(23,24)25/h2-3,6-7H,4-5,8H2,1H3,(H,27,28,29)	PDB UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	98	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...				US Patent US10647727 (2020) BindingDB Entry DOI: 10.7270/Q2KS6VK2
					More data for this Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM442780 (N-(1-(3-Fluoro-4-(trifluoromethyl)phenyl)cycloprop...) Show SMILES Cc1nc(NC2(CC2)c2ccc(c(F)c2)C(F)(F)F)c2ncn(C)c2n1 Show InChI InChI=1S/C17H15F4N5/c1-9-23-14(13-15(24-9)26(2)8-22-13)25-16(5-6-16)10-3-4-11(12(18)7-10)17(19,20)21/h3-4,7-8H,5-6H2,1-2H3,(H,23,24,25)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	115	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...				US Patent US10647727 (2020) BindingDB Entry DOI: 10.7270/Q2KS6VK2
					More data for this Ligand-Target Pair
Phosphodiesterase (Macaca mulatta (Rhesus macaque))	BDBM442756 (6-Chloro-N,1-dimethyl-N-{(1R)-1-[4-(trifluoromethy...) Show SMILES C[C@@H](N(C)c1nc(Cl)nc2n(C)ncc12)c1ccc(cc1)C(F)(F)F |r| Show InChI InChI=1S/C16H15ClF3N5/c1-9(10-4-6-11(7-5-10)16(18,19)20)24(2)13-12-8-21-25(3)14(12)23-15(17)22-13/h4-9H,1-3H3/t9-/m1/s1	PDB UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	137	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...				US Patent US10647727 (2020) BindingDB Entry DOI: 10.7270/Q2KS6VK2
					More data for this Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM442763 (1,6-Dimethyl- N-{(1R)-1-[4- (trifluoromethyl)- phe...) Show SMILES C[C@@H](Nc1nc(C)nc2n(C)ncc12)c1ccc(cc1)C(F)(F)F |r| Show InChI InChI=1S/C16H16F3N5/c1-9(11-4-6-12(7-5-11)16(17,18)19)21-14-13-8-20-24(3)15(13)23-10(2)22-14/h4-9H,1-3H3,(H,21,22,23)/t9-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	US Patent	140	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...				US Patent US10647727 (2020) BindingDB Entry DOI: 10.7270/Q2KS6VK2
					More data for this Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50452210 (CHEMBL4202746 | US10647727, Example 12) Show SMILES Cn1ncc2c(NC3(CC3)c3ccc(cc3)C(F)(F)F)nc(O)nc12 Show InChI InChI=1S/C16H14F3N5O/c1-24-13-11(8-20-24)12(21-14(25)22-13)23-15(6-7-15)9-2-4-10(5-3-9)16(17,18)19/h2-5,8H,6-7H2,1H3,(H2,21,22,23,25)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	141	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...				US Patent US10647727 (2020) BindingDB Entry DOI: 10.7270/Q2KS6VK2
					More data for this Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM442786 (US10647727, Example 43 | [7-({1-[3-Fluoro-4-(trifl...) Show SMILES Cc1cc(NC2(CC2)c2ccc(c(F)c2)C(F)(F)F)n2nc(CO)cc2n1 Show InChI InChI=1S/C18H16F4N4O/c1-10-6-16(26-15(23-10)8-12(9-27)25-26)24-17(4-5-17)11-2-3-13(14(19)7-11)18(20,21)22/h2-3,6-8,24,27H,4-5,9H2,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	169	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...				US Patent US10647727 (2020) BindingDB Entry DOI: 10.7270/Q2KS6VK2
					More data for this Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM442791 (N-{(1R)-1-[3-Fluoro-4-(trifluoromethyl)phenyl]-2,2...) Show SMILES Cc1cc(N[C@@H](c2ccc(c(F)c2)C(F)(F)F)C(C)(C)C)n2nccc2n1 |r| Show InChI InChI=1S/C19H20F4N4/c1-11-9-16(27-15(25-11)7-8-24-27)26-17(18(2,3)4)12-5-6-13(14(20)10-12)19(21,22)23/h5-10,17,26H,1-4H3/t17-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	174	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...				US Patent US10647727 (2020) BindingDB Entry DOI: 10.7270/Q2KS6VK2
					More data for this Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50576273 (CHEMBL4850240) Show SMILES C[C@H](c1nn(CC(F)(F)F)c2c1nc(C)[nH]c2=O)c1ccc(cc1)C(F)(F)F |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	178	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human PDE2				Citation and Details Article DOI: 10.1016/j.bmcl.2021.128082 BindingDB Entry DOI: 10.7270/Q2KK9GNG
					More data for this Ligand-Target Pair
Phosphodiesterase (Macaca mulatta (Rhesus macaque))	BDBM442763 (1,6-Dimethyl- N-{(1R)-1-[4- (trifluoromethyl)- phe...) Show SMILES C[C@@H](Nc1nc(C)nc2n(C)ncc12)c1ccc(cc1)C(F)(F)F |r| Show InChI InChI=1S/C16H16F3N5/c1-9(11-4-6-12(7-5-11)16(17,18)19)21-14-13-8-20-24(3)15(13)23-10(2)22-14/h4-9H,1-3H3,(H,21,22,23)/t9-/m1/s1	PDB UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	US Patent	194	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...				US Patent US10647727 (2020) BindingDB Entry DOI: 10.7270/Q2KS6VK2
					More data for this Ligand-Target Pair
Phosphodiesterase (Macaca mulatta (Rhesus macaque))	BDBM50452210 (CHEMBL4202746 | US10647727, Example 12) Show SMILES Cn1ncc2c(NC3(CC3)c3ccc(cc3)C(F)(F)F)nc(O)nc12 Show InChI InChI=1S/C16H14F3N5O/c1-24-13-11(8-20-24)12(21-14(25)22-13)23-15(6-7-15)9-2-4-10(5-3-9)16(17,18)19/h2-5,8H,6-7H2,1H3,(H2,21,22,23,25)	PDB UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	196	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...				US Patent US10647727 (2020) BindingDB Entry DOI: 10.7270/Q2KS6VK2
					More data for this Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM442790 (N-{1-[3-Fluoro-4-(trifluoromethyl)phenyl]cycloprop...) Show SMILES Cc1cc(NC2(CC2)c2ccc(c(F)c2)C(F)(F)F)n2nccc2n1 Show InChI InChI=1S/C17H14F4N4/c1-10-8-15(25-14(23-10)4-7-22-25)24-16(5-6-16)11-2-3-12(13(18)9-11)17(19,20)21/h2-4,7-9,24H,5-6H2,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	199	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...				US Patent US10647727 (2020) BindingDB Entry DOI: 10.7270/Q2KS6VK2
					More data for this Ligand-Target Pair

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