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Compile Data Set for Download or QSAR

Found 298 hits with Last Name = 'nutt' and Initial = 'rf'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Prothrombin


(Homo sapiens (Human))		BDBM50054502
PNG
(CHEMBL140494 | N-((S)-3-Carbamimidoyl-2-hydroxy-cy...)
Show SMILES NC(=N)C1CCC[C@H](NC(=O)CN2CCC[C@H](NS(=O)(=O)Cc3ccccc3)C2=O)C1O
Show InChI InChI=1S/C21H31N5O5S/c22-20(23)15-8-4-9-16(19(15)28)24-18(27)12-26-11-5-10-17(21(26)29)25-32(30,31)13-14-6-2-1-3-7-14/h1-3,6-7,15-17,19,25,28H,4-5,8-13H2,(H3,22,23)(H,24,27)/t15?,16-,17-,19?/m0/s1
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 1.01n/an/an/an/an/an/an/an/a



Corvas International, Inc.

Curated by ChEMBL


Assay Description
compound was tested in vitro for inhibition of serine protease thrombin(FIIa).

J Med Chem 39: 4531-6 (1996)


Article DOI: 10.1021/jm960572n
BindingDB Entry DOI: 10.7270/Q28051QT
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))		BDBM50087645
PNG
(4-{2-[(R)-1-{[((S)-1-Carbamimidoyl-2-hydroxy-piper...)
Show SMILES CCOC(=O)c1ccc(CCOC(=O)N[C@H](CC2CCN(CC2)C(N)=N)C(=O)NCC(=O)N[C@H]2CCCN(C2O)C(N)=N)cc1
Show InChI InChI=1S/C29H45N9O7/c1-2-44-26(42)20-7-5-18(6-8-20)11-15-45-29(43)36-22(16-19-9-13-37(14-10-19)27(30)31)24(40)34-17-23(39)35-21-4-3-12-38(25(21)41)28(32)33/h5-8,19,21-22,25,41H,2-4,9-17H2,1H3,(H3,30,31)(H3,32,33)(H,34,40)(H,35,39)(H,36,43)/t21-,22+,25?/m0/s1
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 16n/an/an/an/an/an/an/an/a



Corvas International, Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against human Coagulation factor X

Bioorg Med Chem Lett 10: 745-9 (2000)


BindingDB Entry DOI: 10.7270/Q2D50M5R
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))		BDBM50087641
PNG
(3-{[(R)-1-{[((S)-1-Carbamimidoyl-2-hydroxy-piperid...)
Show SMILES NC(=N)N1CCC(C[C@@H](NS(=O)(=O)Cc2cccc(c2)C(O)=O)C(=O)NCC(=O)N[C@H]2CCCN(C2O)C(N)=N)CC1
Show InChI InChI=1S/C25H39N9O7S/c26-24(27)33-9-6-15(7-10-33)12-19(32-42(40,41)14-16-3-1-4-17(11-16)23(38)39)21(36)30-13-20(35)31-18-5-2-8-34(22(18)37)25(28)29/h1,3-4,11,15,18-19,22,32,37H,2,5-10,12-14H2,(H3,26,27)(H3,28,29)(H,30,36)(H,31,35)(H,38,39)/t18-,19+,22?/m0/s1
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 16n/an/an/an/an/an/an/an/a



Corvas International, Inc.

Curated by ChEMBL


Assay Description
In vitro inhibition of human trypsin.

Bioorg Med Chem Lett 10: 745-9 (2000)


BindingDB Entry DOI: 10.7270/Q2D50M5R
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))		BDBM50087639
PNG
((R)-N-[((S)-1-Carbamimidoyl-2-hydroxy-piperidin-3-...)
Show SMILES NC(=N)N1CCC(C[C@@H](NS(=O)(=O)Cc2ccccc2-n2cnnn2)C(=O)NCC(=O)N[C@H]2CCCN(C2O)C(N)=N)CC1
Show InChI InChI=1S/C25H39N13O5S/c26-24(27)36-10-7-16(8-11-36)12-19(22(40)30-13-21(39)32-18-5-3-9-37(23(18)41)25(28)29)33-44(42,43)14-17-4-1-2-6-20(17)38-15-31-34-35-38/h1-2,4,6,15-16,18-19,23,33,41H,3,5,7-14H2,(H3,26,27)(H3,28,29)(H,30,40)(H,32,39)/t18-,19+,23?/m0/s1
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 23n/an/an/an/an/an/an/an/a



Corvas International, Inc.

Curated by ChEMBL


Assay Description
Concentration of the compound required for classical fast inhibition of cleavage of the chromogenic substrate by human enzyme Coagulation factor X in...

Bioorg Med Chem Lett 10: 745-9 (2000)


BindingDB Entry DOI: 10.7270/Q2D50M5R
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))		BDBM50087647
PNG
(CHEMBL162277 | [(R)-1-{[((S)-1-Carbamimidoyl-2-hyd...)
Show SMILES COC(=O)N[C@H](CC1CCN(CC1)C(N)=N)C(=O)NCC(=O)N[C@H]1CCCN(C1O)C(N)=N
Show InChI InChI=1S/C19H35N9O5/c1-33-19(32)26-13(9-11-4-7-27(8-5-11)17(20)21)15(30)24-10-14(29)25-12-3-2-6-28(16(12)31)18(22)23/h11-13,16,31H,2-10H2,1H3,(H3,20,21)(H3,22,23)(H,24,30)(H,25,29)(H,26,32)/t12-,13+,16?/m0/s1
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 23n/an/an/an/an/an/an/an/a



Corvas International, Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against human Coagulation factor X

Bioorg Med Chem Lett 10: 745-9 (2000)


BindingDB Entry DOI: 10.7270/Q2D50M5R
More data for this
Ligand-Target Pair
Prothrombin


(Homo sapiens (Human))		BDBM50289560
PNG
(CHEMBL289389 | N-((S)-1-Carbamimidoyl-2-hydroxy-pi...)
Show SMILES Cc1ccc(NS(=O)(=O)Cc2ccccc2)c(=O)n1CC(=O)N[C@H]1CCCN(C1O)C(N)=N
Show InChI InChI=1S/C21H28N6O5S/c1-14-9-10-17(25-33(31,32)13-15-6-3-2-4-7-15)20(30)27(14)12-18(28)24-16-8-5-11-26(19(16)29)21(22)23/h2-4,6-7,9-10,16,19,25,29H,5,8,11-13H2,1H3,(H3,22,23)(H,24,28)/t16-,19?/m0/s1
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n/an/a 0.467n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory concentration of the compound required to inhibit human thrombin enzyme was determined

Bioorg Med Chem Lett 7: 1543-1548 (1997)


Article DOI: 10.1016/S0960-894X(97)00258-8
BindingDB Entry DOI: 10.7270/Q2HD7VNX
More data for this
Ligand-Target Pair
Prothrombin


(Homo sapiens (Human))		BDBM50076074
PNG
(1N-[1-amino(imino)methyl-6-hydroxy-(5S)-tetrahydro...)
Show SMILES NC(=N)N1CCC[C@H](NC(=O)Cn2cccc(NS(=O)(=O)Cc3ccccc3)c2=O)C1O
Show InChI InChI=1S/C20H26N6O5S/c21-20(22)26-11-5-8-15(19(26)29)23-17(27)12-25-10-4-9-16(18(25)28)24-32(30,31)13-14-6-2-1-3-7-14/h1-4,6-7,9-10,15,19,24,29H,5,8,11-13H2,(H3,21,22)(H,23,27)/t15-,19?/m0/s1
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n/an/a 0.505n/an/an/an/an/an/a



Corvas International, Inc.

Curated by ChEMBL


Assay Description
Concentration required for the in vitro inhibitory activity against human enzyme, thrombin cleavage of the chromogenic substrate

Bioorg Med Chem Lett 9: 895-900 (1999)


BindingDB Entry DOI: 10.7270/Q2NS0T3Q
More data for this
Ligand-Target Pair
Prothrombin


(Homo sapiens (Human))		BDBM50076074
PNG
(1N-[1-amino(imino)methyl-6-hydroxy-(5S)-tetrahydro...)
Show SMILES NC(=N)N1CCC[C@H](NC(=O)Cn2cccc(NS(=O)(=O)Cc3ccccc3)c2=O)C1O
Show InChI InChI=1S/C20H26N6O5S/c21-20(22)26-11-5-8-15(19(26)29)23-17(27)12-25-10-4-9-16(18(25)28)24-32(30,31)13-14-6-2-1-3-7-14/h1-4,6-7,9-10,15,19,24,29H,5,8,11-13H2,(H3,21,22)(H,23,27)/t15-,19?/m0/s1
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n/an/a 0.505n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory concentration of the compound required to inhibit human thrombin enzyme was determined

Bioorg Med Chem Lett 7: 1543-1548 (1997)


Article DOI: 10.1016/S0960-894X(97)00258-8
BindingDB Entry DOI: 10.7270/Q2HD7VNX
More data for this
Ligand-Target Pair
Prothrombin


(Homo sapiens (Human))		BDBM50054486
PNG
(CHEMBL141424 | N-[(S)-1-((S)-1-Carbamimidoyl-piper...)
Show SMILES NC(=N)N1CCC[C@@H](C[C@H](NC(=O)CN2CCC[C@H](NS(=O)(=O)Cc3ccccc3)C2=O)C=O)C1
Show InChI InChI=1S/C23H34N6O5S/c24-23(25)29-11-4-8-18(13-29)12-19(15-30)26-21(31)14-28-10-5-9-20(22(28)32)27-35(33,34)16-17-6-2-1-3-7-17/h1-3,6-7,15,18-20,27H,4-5,8-14,16H2,(H3,24,25)(H,26,31)/t18-,19-,20-/m0/s1
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n/an/a 0.670n/an/an/an/an/an/a



Corvas International Inc.

Curated by ChEMBL


Assay Description
Compound was evaluated for inhibition of amidolytic activity for chromogenic substrate thrombin F11a.

J Med Chem 39: 4527-30 (1996)


Article DOI: 10.1021/jm960607j
BindingDB Entry DOI: 10.7270/Q2CR5SFV
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Prothrombin


(Homo sapiens (Human))		BDBM50054498
PNG
((R)-1-((R)-2-Methylamino-3-phenyl-propionyl)-pyrro...)
Show SMILES CN[C@H](Cc1ccccc1)C(=O)N1CCC[C@@H]1C(=O)N[C@H]1CCCC(C1O)C(N)=N
Show InChI InChI=1S/C22H33N5O3/c1-25-17(13-14-7-3-2-4-8-14)22(30)27-12-6-11-18(27)21(29)26-16-10-5-9-15(19(16)28)20(23)24/h2-4,7-8,15-19,25,28H,5-6,9-13H2,1H3,(H3,23,24)(H,26,29)/t15?,16-,17+,18+,19?/m0/s1
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n/an/a 0.700n/an/an/an/an/an/a



Corvas International, Inc.

Curated by ChEMBL


Assay Description
In vitro for inhibition of serine protease thrombin(FIIa).

J Med Chem 39: 4531-6 (1996)


Article DOI: 10.1021/jm960572n
BindingDB Entry DOI: 10.7270/Q28051QT
More data for this
Ligand-Target Pair
Prothrombin


(Homo sapiens (Human))		BDBM50073429
PNG
(CHEMBL82032 | CHEMBL84575 | N-((S)-1-Carbamimidoyl...)
Show SMILES NC(=N)N1CCC[C@H](NC(=O)CN2CCCC[C@H](NS(=O)(=O)Cc3ccccc3)C2=O)C1O
Show InChI InChI=1S/C21H32N6O5S/c22-21(23)27-12-6-10-16(20(27)30)24-18(28)13-26-11-5-4-9-17(19(26)29)25-33(31,32)14-15-7-2-1-3-8-15/h1-3,7-8,16-17,20,25,30H,4-6,9-14H2,(H3,22,23)(H,24,28)/t16-,17-,20?/m0/s1
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n/an/a 0.710n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
The compound was tested in vitro for inhibitory activity against Coagulation factor II

Bioorg Med Chem Lett 7: 2421-2426 (1997)


Article DOI: 10.1016/S0960-894X(97)00446-0
BindingDB Entry DOI: 10.7270/Q2X92B91
More data for this
Ligand-Target Pair
Prothrombin


(Homo sapiens (Human))		BDBM50054493
PNG
(CHEMBL343805 | N-((S)-3-Carbamimidoyl-2-hydroxy-cy...)
Show SMILES NC(=N)C1CCC[C@H](NC(=O)CN2CCCC[C@H](NS(=O)(=O)Cc3ccccc3)C2=O)C1O
Show InChI InChI=1S/C22H33N5O5S/c23-21(24)16-9-6-11-17(20(16)29)25-19(28)13-27-12-5-4-10-18(22(27)30)26-33(31,32)14-15-7-2-1-3-8-15/h1-3,7-8,16-18,20,26,29H,4-6,9-14H2,(H3,23,24)(H,25,28)/t16?,17-,18-,20?/m0/s1
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n/an/a 0.710n/an/an/an/an/an/a



Corvas International, Inc.

Curated by ChEMBL


Assay Description
In vitro for inhibition of serine protease thrombin(FIIa).

J Med Chem 39: 4531-6 (1996)


Article DOI: 10.1021/jm960572n
BindingDB Entry DOI: 10.7270/Q28051QT
More data for this
Ligand-Target Pair
Prothrombin


(Homo sapiens (Human))		BDBM50054484
PNG
(CHEMBL344204 | CVS-1778 | N-((S)-1-Formyl-4-guanid...)
Show SMILES NC(=N)NCCC[C@H](NC(=O)CN1CCCC[C@H](NS(=O)(=O)Cc2ccccc2)C1=O)C=O
Show InChI InChI=1S/C21H32N6O5S/c22-21(23)24-11-6-9-17(14-28)25-19(29)13-27-12-5-4-10-18(20(27)30)26-33(31,32)15-16-7-2-1-3-8-16/h1-3,7-8,14,17-18,26H,4-6,9-13,15H2,(H,25,29)(H4,22,23,24)/t17-,18-/m0/s1
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n/an/a 0.710n/an/an/an/an/an/a



Corvas International Inc.

Curated by ChEMBL


Assay Description
Compound was evaluated for inhibition of amidolytic activity for chromogenic substrate thrombin F11a.

J Med Chem 39: 4527-30 (1996)


Article DOI: 10.1021/jm960607j
BindingDB Entry DOI: 10.7270/Q2CR5SFV
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))		BDBM50087644
PNG
((R)-N-[((S)-1-Carbamimidoyl-2-hydroxy-piperidin-3-...)
Show SMILES NC(=N)N1CCC(C[C@@H](NS(=O)(=O)Cc2ccccc2)C(=O)NCC(=O)N[C@H]2CCCN(C2O)C(N)=N)CC1
Show InChI InChI=1S/C24H39N9O5S/c25-23(26)32-11-8-16(9-12-32)13-19(31-39(37,38)15-17-5-2-1-3-6-17)21(35)29-14-20(34)30-18-7-4-10-33(22(18)36)24(27)28/h1-3,5-6,16,18-19,22,31,36H,4,7-15H2,(H3,25,26)(H3,27,28)(H,29,35)(H,30,34)/t18-,19+,22?/m0/s1
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n/an/a 0.830n/an/an/an/an/an/a



Corvas International, Inc.

Curated by ChEMBL


Assay Description
In vitro inhibition of human Coagulation factor X.

Bioorg Med Chem Lett 10: 745-9 (2000)


BindingDB Entry DOI: 10.7270/Q2D50M5R
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))		BDBM50087635
PNG
(((R)-1-{[((S)-1-Carbamimidoyl-2-hydroxy-piperidin-...)
Show SMILES NC(=N)NCCC[C@@H](NC(=O)OCc1ccccc1)C(=O)NCC(=O)N[C@H]1CCCN(C1O)C(N)=N
Show InChI InChI=1S/C22H35N9O5/c23-20(24)27-10-4-8-15(30-22(35)36-13-14-6-2-1-3-7-14)18(33)28-12-17(32)29-16-9-5-11-31(19(16)34)21(25)26/h1-3,6-7,15-16,19,34H,4-5,8-13H2,(H3,25,26)(H,28,33)(H,29,32)(H,30,35)(H4,23,24,27)/t15-,16+,19?/m1/s1
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n/an/a 0.900n/an/an/an/an/an/a



Corvas International, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human VCAM and Ramos cell VLA-4 interaction

Bioorg Med Chem Lett 10: 745-9 (2000)


BindingDB Entry DOI: 10.7270/Q2D50M5R
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))		BDBM50087635
PNG
(((R)-1-{[((S)-1-Carbamimidoyl-2-hydroxy-piperidin-...)
Show SMILES NC(=N)NCCC[C@@H](NC(=O)OCc1ccccc1)C(=O)NCC(=O)N[C@H]1CCCN(C1O)C(N)=N
Show InChI InChI=1S/C22H35N9O5/c23-20(24)27-10-4-8-15(30-22(35)36-13-14-6-2-1-3-7-14)18(33)28-12-17(32)29-16-9-5-11-31(19(16)34)21(25)26/h1-3,6-7,15-16,19,34H,4-5,8-13H2,(H3,25,26)(H,28,33)(H,29,32)(H,30,35)(H4,23,24,27)/t15-,16+,19?/m1/s1
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n/an/a 0.900n/an/an/an/an/an/a



Corvas International, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human VCAM and Ramos cell VLA-4 interaction

Bioorg Med Chem Lett 10: 745-9 (2000)


BindingDB Entry DOI: 10.7270/Q2D50M5R
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))		BDBM50087635
PNG
(((R)-1-{[((S)-1-Carbamimidoyl-2-hydroxy-piperidin-...)
Show SMILES NC(=N)NCCC[C@@H](NC(=O)OCc1ccccc1)C(=O)NCC(=O)N[C@H]1CCCN(C1O)C(N)=N
Show InChI InChI=1S/C22H35N9O5/c23-20(24)27-10-4-8-15(30-22(35)36-13-14-6-2-1-3-7-14)18(33)28-12-17(32)29-16-9-5-11-31(19(16)34)21(25)26/h1-3,6-7,15-16,19,34H,4-5,8-13H2,(H3,25,26)(H,28,33)(H,29,32)(H,30,35)(H4,23,24,27)/t15-,16+,19?/m1/s1
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n/an/a 0.900n/an/an/an/an/an/a



Corvas International, Inc.

Curated by ChEMBL


Assay Description
In vitro inhibition of human Coagulation factor X.

Bioorg Med Chem Lett 10: 745-9 (2000)


BindingDB Entry DOI: 10.7270/Q2D50M5R
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))		BDBM50087638
PNG
((R)-5-Guanidino-2-phenylmethanesulfonylamino-penta...)
Show SMILES NC(=N)NCCC[C@@H](NS(=O)(=O)Cc1ccccc1)C(=O)NCC(=O)N[C@H]1CCCN(C1O)C(N)=N
Show InChI InChI=1S/C21H35N9O5S/c22-20(23)26-10-4-8-15(29-36(34,35)13-14-6-2-1-3-7-14)18(32)27-12-17(31)28-16-9-5-11-30(19(16)33)21(24)25/h1-3,6-7,15-16,19,29,33H,4-5,8-13H2,(H3,24,25)(H,27,32)(H,28,31)(H4,22,23,26)/t15-,16+,19?/m1/s1
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n/an/a 0.900n/an/an/an/an/an/a



Corvas International, Inc.

Curated by ChEMBL


Assay Description
In vitro inhibition of human Coagulation factor X.

Bioorg Med Chem Lett 10: 745-9 (2000)


BindingDB Entry DOI: 10.7270/Q2D50M5R
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))		BDBM50087636
PNG
((R)-N-[((S)-1-Carbamimidoyl-2-hydroxy-piperidin-3-...)
Show SMILES NC(=N)N1CCCC(C[C@@H](NS(=O)(=O)Cc2ccccc2)C(=O)NCC(=O)N[C@H]2CCCN(C2O)C(N)=N)C1
Show InChI InChI=1S/C24H39N9O5S/c25-23(26)32-10-4-8-17(14-32)12-19(31-39(37,38)15-16-6-2-1-3-7-16)21(35)29-13-20(34)30-18-9-5-11-33(22(18)36)24(27)28/h1-3,6-7,17-19,22,31,36H,4-5,8-15H2,(H3,25,26)(H3,27,28)(H,29,35)(H,30,34)/t17?,18-,19+,22?/m0/s1
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n/an/a 0.920n/an/an/an/an/an/a



Corvas International, Inc.

Curated by ChEMBL


Assay Description
In vitro inhibition of human Coagulation factor X.

Bioorg Med Chem Lett 10: 745-9 (2000)


BindingDB Entry DOI: 10.7270/Q2D50M5R
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))		BDBM50087636
PNG
((R)-N-[((S)-1-Carbamimidoyl-2-hydroxy-piperidin-3-...)
Show SMILES NC(=N)N1CCCC(C[C@@H](NS(=O)(=O)Cc2ccccc2)C(=O)NCC(=O)N[C@H]2CCCN(C2O)C(N)=N)C1
Show InChI InChI=1S/C24H39N9O5S/c25-23(26)32-10-4-8-17(14-32)12-19(31-39(37,38)15-16-6-2-1-3-7-16)21(35)29-13-20(34)30-18-9-5-11-33(22(18)36)24(27)28/h1-3,6-7,17-19,22,31,36H,4-5,8-15H2,(H3,25,26)(H3,27,28)(H,29,35)(H,30,34)/t17?,18-,19+,22?/m0/s1
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n/an/a 0.920n/an/an/an/an/an/a



Corvas International, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human VCAM and Ramos cell VLA-4 interaction

Bioorg Med Chem Lett 10: 745-9 (2000)


BindingDB Entry DOI: 10.7270/Q2D50M5R
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))		BDBM50087643
PNG
(2-{[(R)-1-{[((S)-1-Carbamimidoyl-2-hydroxy-piperid...)
Show SMILES COC(=O)c1ccccc1CS(=O)(=O)N[C@H](CC1CCN(CC1)C(N)=N)C(=O)NCC(=O)N[C@H]1CCCN(C1O)C(N)=N
Show InChI InChI=1S/C26H41N9O7S/c1-42-24(39)18-6-3-2-5-17(18)15-43(40,41)33-20(13-16-8-11-34(12-9-16)25(27)28)22(37)31-14-21(36)32-19-7-4-10-35(23(19)38)26(29)30/h2-3,5-6,16,19-20,23,33,38H,4,7-15H2,1H3,(H3,27,28)(H3,29,30)(H,31,37)(H,32,36)/t19-,20+,23?/m0/s1
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n/an/a 0.940n/an/an/an/an/an/a



Corvas International, Inc.

Curated by ChEMBL


Assay Description
In vitro inhibition of human Coagulation factor X.

Bioorg Med Chem Lett 10: 745-9 (2000)


BindingDB Entry DOI: 10.7270/Q2D50M5R
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))		BDBM50087642
PNG
(CHEMBL163251 | N-[((S)-1-Carbamimidoyl-2-hydroxy-p...)
Show SMILES NC(=N)N1CCC(CC1)C(NS(=O)(=O)Cc1ccccc1)C(=O)NCC(=O)N[C@H]1CCCN(C1O)C(N)=N
Show InChI InChI=1S/C23H37N9O5S/c24-22(25)31-11-8-16(9-12-31)19(30-38(36,37)14-15-5-2-1-3-6-15)20(34)28-13-18(33)29-17-7-4-10-32(21(17)35)23(26)27/h1-3,5-6,16-17,19,21,30,35H,4,7-14H2,(H3,24,25)(H3,26,27)(H,28,34)(H,29,33)/t17-,19?,21?/m0/s1
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n/an/a 1.10n/an/an/an/an/an/a



Corvas International, Inc.

Curated by ChEMBL


Assay Description
In vitro inhibition of human Coagulation factor X.

Bioorg Med Chem Lett 10: 745-9 (2000)


BindingDB Entry DOI: 10.7270/Q2D50M5R
More data for this
Ligand-Target Pair
Prothrombin


(Homo sapiens (Human))		BDBM50054492
PNG
((S)-4-[(R)-2-((S)-3-Carbamimidoyl-2-hydroxy-cycloh...)
Show SMILES CCCC(CCC)C(=O)N[C@@H](CC(=O)OC)C(=O)N1CCC[C@@H]1C(=O)N[C@H]1CCCC(C1O)C(N)=N
Show InChI InChI=1S/C25H43N5O6/c1-4-8-15(9-5-2)23(33)29-18(14-20(31)36-3)25(35)30-13-7-12-19(30)24(34)28-17-11-6-10-16(21(17)32)22(26)27/h15-19,21,32H,4-14H2,1-3H3,(H3,26,27)(H,28,34)(H,29,33)/t16?,17-,18-,19+,21?/m0/s1
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n/an/a 1.10n/an/an/an/an/an/a



Corvas International, Inc.

Curated by ChEMBL


Assay Description
In vitro for inhibition of serine protease thrombin(FIIa).

J Med Chem 39: 4531-6 (1996)


Article DOI: 10.1021/jm960572n
BindingDB Entry DOI: 10.7270/Q28051QT
More data for this
Ligand-Target Pair
Prothrombin


(Homo sapiens (Human))		BDBM50054494
PNG
(2-({(S)-1-[((S)-3-Carbamimidoyl-2-hydroxy-cyclohex...)
Show SMILES COC(=O)c1ccccc1CS(=O)(=O)N[C@H]1CCCCN(CC(=O)N[C@H]2CCCC(C2O)C(N)=N)C1=O
Show InChI InChI=1S/C24H35N5O7S/c1-36-24(33)16-8-3-2-7-15(16)14-37(34,35)28-19-10-4-5-12-29(23(19)32)13-20(30)27-18-11-6-9-17(21(18)31)22(25)26/h2-3,7-8,17-19,21,28,31H,4-6,9-14H2,1H3,(H3,25,26)(H,27,30)/t17?,18-,19-,21?/m0/s1
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n/an/a 1.12n/an/an/an/an/an/a



Corvas International, Inc.

Curated by ChEMBL


Assay Description
In vitro for inhibition of serine protease thrombin(FIIa).

J Med Chem 39: 4531-6 (1996)


Article DOI: 10.1021/jm960572n
BindingDB Entry DOI: 10.7270/Q28051QT
More data for this
Ligand-Target Pair
Anionic trypsin


(Bos taurus)		BDBM50054482
PNG
((S)-4-[(S)-2-((S)-1-Formyl-4-guanidino-butylcarbam...)
Show SMILES CCCC(CCC)C(=O)N[C@@H](CC(=O)OC)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C=O
Show InChI InChI=1S/C24H42N6O6/c1-4-8-16(9-5-2)21(33)29-18(14-20(32)36-3)23(35)30-13-7-11-19(30)22(34)28-17(15-31)10-6-12-27-24(25)26/h15-19H,4-14H2,1-3H3,(H,28,34)(H,29,33)(H4,25,26,27)/t17-,18-,19-/m0/s1
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n/an/a 1.20n/an/an/an/an/an/a



Corvas International Inc.

Curated by ChEMBL


Assay Description
Compound was evaluated for inhibition of amidolytic activity for chromogenic substrate trypsin

J Med Chem 39: 4527-30 (1996)


Article DOI: 10.1021/jm960607j
BindingDB Entry DOI: 10.7270/Q2CR5SFV
More data for this
Ligand-Target Pair
Prothrombin


(Homo sapiens (Human))		BDBM50054482
PNG
((S)-4-[(S)-2-((S)-1-Formyl-4-guanidino-butylcarbam...)
Show SMILES CCCC(CCC)C(=O)N[C@@H](CC(=O)OC)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C=O
Show InChI InChI=1S/C24H42N6O6/c1-4-8-16(9-5-2)21(33)29-18(14-20(32)36-3)23(35)30-13-7-11-19(30)22(34)28-17(15-31)10-6-12-27-24(25)26/h15-19H,4-14H2,1-3H3,(H,28,34)(H,29,33)(H4,25,26,27)/t17-,18-,19-/m0/s1
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n/an/a 1.20n/an/an/an/an/an/a



Corvas International Inc.

Curated by ChEMBL


Assay Description
Compound was evaluated for inhibition of amidolytic activity for chromogenic substrate thrombin F11a.

J Med Chem 39: 4527-30 (1996)


Article DOI: 10.1021/jm960607j
BindingDB Entry DOI: 10.7270/Q2CR5SFV
More data for this
Ligand-Target Pair
Serine protease 1


(Homo sapiens (Human))		BDBM50054492
PNG
((S)-4-[(R)-2-((S)-3-Carbamimidoyl-2-hydroxy-cycloh...)
Show SMILES CCCC(CCC)C(=O)N[C@@H](CC(=O)OC)C(=O)N1CCC[C@@H]1C(=O)N[C@H]1CCCC(C1O)C(N)=N
Show InChI InChI=1S/C25H43N5O6/c1-4-8-15(9-5-2)23(33)29-18(14-20(31)36-3)25(35)30-13-7-12-19(30)24(34)28-17-11-6-10-16(21(17)32)22(26)27/h15-19,21,32H,4-14H2,1-3H3,(H3,26,27)(H,28,34)(H,29,33)/t16?,17-,18-,19+,21?/m0/s1
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n/an/a 1.36n/an/an/an/an/an/a



Corvas International, Inc.

Curated by ChEMBL


Assay Description
In vitro for inhibition of serine protease Trypsin.

J Med Chem 39: 4531-6 (1996)


Article DOI: 10.1021/jm960572n
BindingDB Entry DOI: 10.7270/Q28051QT
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))		BDBM50087640
PNG
(2-{[(R)-1-{[((S)-1-Carbamimidoyl-2-hydroxy-piperid...)
Show SMILES COC(=O)c1ccccc1CS(=O)(=O)N[C@H](CC1CCCN(C1)C(N)=N)C(=O)NCC(=O)N[C@H]1CCCN(C1O)C(N)=N
Show InChI InChI=1S/C26H41N9O7S/c1-42-24(39)18-8-3-2-7-17(18)15-43(40,41)33-20(12-16-6-4-10-34(14-16)25(27)28)22(37)31-13-21(36)32-19-9-5-11-35(23(19)38)26(29)30/h2-3,7-8,16,19-20,23,33,38H,4-6,9-15H2,1H3,(H3,27,28)(H3,29,30)(H,31,37)(H,32,36)/t16?,19-,20+,23?/m0/s1
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n/an/a 1.37n/an/an/an/an/an/a



Corvas International, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human VCAM binding to VLA-4 of Ramos cells in ELISA

Bioorg Med Chem Lett 10: 745-9 (2000)


BindingDB Entry DOI: 10.7270/Q2D50M5R
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))		BDBM50087640
PNG
(2-{[(R)-1-{[((S)-1-Carbamimidoyl-2-hydroxy-piperid...)
Show SMILES COC(=O)c1ccccc1CS(=O)(=O)N[C@H](CC1CCCN(C1)C(N)=N)C(=O)NCC(=O)N[C@H]1CCCN(C1O)C(N)=N
Show InChI InChI=1S/C26H41N9O7S/c1-42-24(39)18-8-3-2-7-17(18)15-43(40,41)33-20(12-16-6-4-10-34(14-16)25(27)28)22(37)31-13-21(36)32-19-9-5-11-35(23(19)38)26(29)30/h2-3,7-8,16,19-20,23,33,38H,4-6,9-15H2,1H3,(H3,27,28)(H3,29,30)(H,31,37)(H,32,36)/t16?,19-,20+,23?/m0/s1
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n/an/a 1.40n/an/an/an/an/an/a



Corvas International, Inc.

Curated by ChEMBL


Assay Description
In vitro inhibition of human Coagulation factor X.

Bioorg Med Chem Lett 10: 745-9 (2000)


BindingDB Entry DOI: 10.7270/Q2D50M5R
More data for this
Ligand-Target Pair
Serine protease 1


(Homo sapiens (Human))		BDBM50054498
PNG
((R)-1-((R)-2-Methylamino-3-phenyl-propionyl)-pyrro...)
Show SMILES CN[C@H](Cc1ccccc1)C(=O)N1CCC[C@@H]1C(=O)N[C@H]1CCCC(C1O)C(N)=N
Show InChI InChI=1S/C22H33N5O3/c1-25-17(13-14-7-3-2-4-8-14)22(30)27-12-6-11-18(27)21(29)26-16-10-5-9-15(19(16)28)20(23)24/h2-4,7-8,15-19,25,28H,5-6,9-13H2,1H3,(H3,23,24)(H,26,29)/t15?,16-,17+,18+,19?/m0/s1
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n/an/a 1.52n/an/an/an/an/an/a



Corvas International, Inc.

Curated by ChEMBL


Assay Description
In vitro for inhibition of serine protease Trypsin.

J Med Chem 39: 4531-6 (1996)


Article DOI: 10.1021/jm960572n
BindingDB Entry DOI: 10.7270/Q28051QT
More data for this
Ligand-Target Pair
Prothrombin


(Homo sapiens (Human))		BDBM50054483
PNG
((S)-4-{(S)-2-[(S)-1-(1-Carbamimidoyl-piperidin-3-y...)
Show SMILES CCCC(CCC)C(=O)N[C@@H](CC(=O)OC)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1CCCN(C1)C(N)=N)C=O
Show InChI InChI=1S/C27H46N6O6/c1-4-8-19(9-5-2)24(36)31-21(15-23(35)39-3)26(38)33-13-7-11-22(33)25(37)30-20(17-34)14-18-10-6-12-32(16-18)27(28)29/h17-22H,4-16H2,1-3H3,(H3,28,29)(H,30,37)(H,31,36)/t18?,20-,21-,22-/m0/s1
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n/an/a 1.70n/an/an/an/an/an/a



Corvas International Inc.

Curated by ChEMBL


Assay Description
Compound was evaluated for inhibition of amidolytic activity for chromogenic substrate thrombin F11a.

J Med Chem 39: 4527-30 (1996)


Article DOI: 10.1021/jm960607j
BindingDB Entry DOI: 10.7270/Q2CR5SFV
More data for this
Ligand-Target Pair
Prothrombin


(Homo sapiens (Human))		BDBM50054483
PNG
((S)-4-{(S)-2-[(S)-1-(1-Carbamimidoyl-piperidin-3-y...)
Show SMILES CCCC(CCC)C(=O)N[C@@H](CC(=O)OC)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1CCCN(C1)C(N)=N)C=O
Show InChI InChI=1S/C27H46N6O6/c1-4-8-19(9-5-2)24(36)31-21(15-23(35)39-3)26(38)33-13-7-11-22(33)25(37)30-20(17-34)14-18-10-6-12-32(16-18)27(28)29/h17-22H,4-16H2,1-3H3,(H3,28,29)(H,30,37)(H,31,36)/t18?,20-,21-,22-/m0/s1
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n/an/a 1.70n/an/an/an/an/an/a



Corvas International Inc.

Curated by ChEMBL


Assay Description
Compound was evaluated for inhibition of amidolytic activity for chromogenic substrate thrombin F11a.

J Med Chem 39: 4527-30 (1996)


Article DOI: 10.1021/jm960607j
BindingDB Entry DOI: 10.7270/Q2CR5SFV
More data for this
Ligand-Target Pair
Prothrombin


(Homo sapiens (Human))		BDBM50054487
PNG
(CHEMBL342914 | N-[(S)-1-(1-Carbamimidoyl-piperidin...)
Show SMILES NC(=N)N1CCCC(C[C@H](NC(=O)CN2CCCC[C@H](NS(=O)(=O)Cc3ccccc3)C2=O)C=O)C1
Show InChI InChI=1S/C24H36N6O5S/c25-24(26)30-12-6-9-19(14-30)13-20(16-31)27-22(32)15-29-11-5-4-10-21(23(29)33)28-36(34,35)17-18-7-2-1-3-8-18/h1-3,7-8,16,19-21,28H,4-6,9-15,17H2,(H3,25,26)(H,27,32)/t19?,20-,21-/m0/s1
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n/an/a 1.80n/an/an/an/an/an/a



Corvas International Inc.

Curated by ChEMBL


Assay Description
Compound was evaluated for inhibition of amidolytic activity for chromogenic substrate thrombin F11a.

J Med Chem 39: 4527-30 (1996)


Article DOI: 10.1021/jm960607j
BindingDB Entry DOI: 10.7270/Q2CR5SFV
More data for this
Ligand-Target Pair
Prothrombin


(Homo sapiens (Human))		BDBM50054487
PNG
(CHEMBL342914 | N-[(S)-1-(1-Carbamimidoyl-piperidin...)
Show SMILES NC(=N)N1CCCC(C[C@H](NC(=O)CN2CCCC[C@H](NS(=O)(=O)Cc3ccccc3)C2=O)C=O)C1
Show InChI InChI=1S/C24H36N6O5S/c25-24(26)30-12-6-9-19(14-30)13-20(16-31)27-22(32)15-29-11-5-4-10-21(23(29)33)28-36(34,35)17-18-7-2-1-3-8-18/h1-3,7-8,16,19-21,28H,4-6,9-15,17H2,(H3,25,26)(H,27,32)/t19?,20-,21-/m0/s1
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n/an/a 1.80n/an/an/an/an/an/a



Corvas International Inc.

Curated by ChEMBL


Assay Description
Compound was evaluated for inhibition of amidolytic activity for chromogenic substrate thrombin F11a.

J Med Chem 39: 4527-30 (1996)


Article DOI: 10.1021/jm960607j
BindingDB Entry DOI: 10.7270/Q2CR5SFV
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))		BDBM50087637
PNG
(2-{[(R)-1-{[((S)-1-Carbamimidoyl-2-hydroxy-piperid...)
Show SMILES NC(=N)N1CCCC(C[C@@H](NS(=O)(=O)Cc2ccccc2C(O)=O)C(=O)NCC(=O)N[C@H]2CCCN(C2O)C(N)=N)C1
Show InChI InChI=1S/C25H39N9O7S/c26-24(27)33-9-3-5-15(13-33)11-19(32-42(40,41)14-16-6-1-2-7-17(16)23(38)39)21(36)30-12-20(35)31-18-8-4-10-34(22(18)37)25(28)29/h1-2,6-7,15,18-19,22,32,37H,3-5,8-14H2,(H3,26,27)(H3,28,29)(H,30,36)(H,31,35)(H,38,39)/t15?,18-,19+,22?/m0/s1
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n/an/a 2.10n/an/an/an/an/an/a



Corvas International, Inc.

Curated by ChEMBL


Assay Description
In vitro inhibition of human Coagulation factor X.

Bioorg Med Chem Lett 10: 745-9 (2000)


BindingDB Entry DOI: 10.7270/Q2D50M5R
More data for this
Ligand-Target Pair
Prothrombin


(Homo sapiens (Human))		BDBM50081158
PNG
(2-((R)-3-Amino-3-benzyl-2-oxo-piperidin-1-yl)-N-((...)
Show SMILES NC(=N)N1CCC[C@H](NC(=O)CN2CCC[C@@](N)(Cc3ccccc3)C2=O)C1O
Show InChI InChI=1S/C20H30N6O3/c21-19(22)26-11-4-8-15(17(26)28)24-16(27)13-25-10-5-9-20(23,18(25)29)12-14-6-2-1-3-7-14/h1-3,6-7,15,17,28H,4-5,8-13,23H2,(H3,21,22)(H,24,27)/t15-,17?,20+/m0/s1
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n/an/a 2.10n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
The compound was tested in vitro for inhibitory activity against Coagulation factor II

Bioorg Med Chem Lett 7: 2421-2426 (1997)


Article DOI: 10.1016/S0960-894X(97)00446-0
BindingDB Entry DOI: 10.7270/Q2X92B91
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))		BDBM50087637
PNG
(2-{[(R)-1-{[((S)-1-Carbamimidoyl-2-hydroxy-piperid...)
Show SMILES NC(=N)N1CCCC(C[C@@H](NS(=O)(=O)Cc2ccccc2C(O)=O)C(=O)NCC(=O)N[C@H]2CCCN(C2O)C(N)=N)C1
Show InChI InChI=1S/C25H39N9O7S/c26-24(27)33-9-3-5-15(13-33)11-19(32-42(40,41)14-16-6-1-2-7-17(16)23(38)39)21(36)30-12-20(35)31-18-8-4-10-34(22(18)37)25(28)29/h1-2,6-7,15,18-19,22,32,37H,3-5,8-14H2,(H3,26,27)(H3,28,29)(H,30,36)(H,31,35)(H,38,39)/t15?,18-,19+,22?/m0/s1
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n/an/a 2.10n/an/an/an/an/an/a



Corvas International, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human VCAM binding to VLA-4 of Ramos cells in ELISA

Bioorg Med Chem Lett 10: 745-9 (2000)


BindingDB Entry DOI: 10.7270/Q2D50M5R
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))		BDBM50087634
PNG
(3-{[(R)-1-{[((S)-1-Carbamimidoyl-2-hydroxy-piperid...)
Show SMILES COC(=O)c1cccc(CS(=O)(=O)N[C@H](CC2CCN(CC2)C(N)=N)C(=O)NCC(=O)N[C@H]2CCCN(C2O)C(N)=N)c1
Show InChI InChI=1S/C26H41N9O7S/c1-42-24(39)18-5-2-4-17(12-18)15-43(40,41)33-20(13-16-7-10-34(11-8-16)25(27)28)22(37)31-14-21(36)32-19-6-3-9-35(23(19)38)26(29)30/h2,4-5,12,16,19-20,23,33,38H,3,6-11,13-15H2,1H3,(H3,27,28)(H3,29,30)(H,31,37)(H,32,36)/t19-,20+,23?/m0/s1
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n/an/a 2.20n/an/an/an/an/an/a



Corvas International, Inc.

Curated by ChEMBL


Assay Description
In vitro inhibition of human Coagulation factor X.

Bioorg Med Chem Lett 10: 745-9 (2000)


BindingDB Entry DOI: 10.7270/Q2D50M5R
More data for this
Ligand-Target Pair
Prothrombin


(Homo sapiens (Human))		BDBM50289559
PNG
(CHEMBL39475 | N-((S)-1-Carbamimidoyl-2-hydroxy-pip...)
Show SMILES Cc1ncc(NS(=O)(=O)Cc2ccccc2)c(=O)n1CC(=O)N[C@H]1CCCN(C1O)C(N)=N
Show InChI InChI=1S/C20H27N7O5S/c1-13-23-10-16(25-33(31,32)12-14-6-3-2-4-7-14)19(30)27(13)11-17(28)24-15-8-5-9-26(18(15)29)20(21)22/h2-4,6-7,10,15,18,25,29H,5,8-9,11-12H2,1H3,(H3,21,22)(H,24,28)/t15-,18?/m0/s1
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n/an/a 2.30n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory concentration of the compound required to inhibit human thrombin enzyme was determined

Bioorg Med Chem Lett 7: 1543-1548 (1997)


Article DOI: 10.1016/S0960-894X(97)00258-8
BindingDB Entry DOI: 10.7270/Q2HD7VNX
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))		BDBM50087639
PNG
((R)-N-[((S)-1-Carbamimidoyl-2-hydroxy-piperidin-3-...)
Show SMILES NC(=N)N1CCC(C[C@@H](NS(=O)(=O)Cc2ccccc2-n2cnnn2)C(=O)NCC(=O)N[C@H]2CCCN(C2O)C(N)=N)CC1
Show InChI InChI=1S/C25H39N13O5S/c26-24(27)36-10-7-16(8-11-36)12-19(22(40)30-13-21(39)32-18-5-3-9-37(23(18)41)25(28)29)33-44(42,43)14-17-4-1-2-6-20(17)38-15-31-34-35-38/h1-2,4,6,15-16,18-19,23,33,41H,3,5,7-14H2,(H3,26,27)(H3,28,29)(H,30,40)(H,32,39)/t18-,19+,23?/m0/s1
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n/an/a 2.60n/an/an/an/an/an/a



Corvas International, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human VCAM binding to VLA-4 of Ramos cells in ELISA

Bioorg Med Chem Lett 10: 745-9 (2000)


BindingDB Entry DOI: 10.7270/Q2D50M5R
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))		BDBM50087641
PNG
(3-{[(R)-1-{[((S)-1-Carbamimidoyl-2-hydroxy-piperid...)
Show SMILES NC(=N)N1CCC(C[C@@H](NS(=O)(=O)Cc2cccc(c2)C(O)=O)C(=O)NCC(=O)N[C@H]2CCCN(C2O)C(N)=N)CC1
Show InChI InChI=1S/C25H39N9O7S/c26-24(27)33-9-6-15(7-10-33)12-19(32-42(40,41)14-16-3-1-4-17(11-16)23(38)39)21(36)30-13-20(35)31-18-5-2-8-34(22(18)37)25(28)29/h1,3-4,11,15,18-19,22,32,37H,2,5-10,12-14H2,(H3,26,27)(H3,28,29)(H,30,36)(H,31,35)(H,38,39)/t18-,19+,22?/m0/s1
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n/an/a 4.30n/an/an/an/an/an/a



Corvas International, Inc.

Curated by ChEMBL


Assay Description
In vitro inhibition of human Coagulation factor X.

Bioorg Med Chem Lett 10: 745-9 (2000)


BindingDB Entry DOI: 10.7270/Q2D50M5R
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))		BDBM50087646
PNG
(2-{[(R)-1-{[((S)-1-Carbamimidoyl-2-hydroxy-piperid...)
Show SMILES NC(=N)N1CCC(C[C@@H](NS(=O)(=O)Cc2ccccc2C(O)=O)C(=O)NCC(=O)N[C@H]2CCCN(C2O)C(N)=N)CC1
Show InChI InChI=1S/C25H39N9O7S/c26-24(27)33-10-7-15(8-11-33)12-19(32-42(40,41)14-16-4-1-2-5-17(16)23(38)39)21(36)30-13-20(35)31-18-6-3-9-34(22(18)37)25(28)29/h1-2,4-5,15,18-19,22,32,37H,3,6-14H2,(H3,26,27)(H3,28,29)(H,30,36)(H,31,35)(H,38,39)/t18-,19+,22?/m0/s1
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n/an/a 5.30n/an/an/an/an/an/a



Corvas International, Inc.

Curated by ChEMBL


Assay Description
Concentration of the compound required to inhibit the cleavage of the chromogenic substrate by human enzyme Coagulation factor X in vitro

Bioorg Med Chem Lett 10: 745-9 (2000)


BindingDB Entry DOI: 10.7270/Q2D50M5R
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))		BDBM50087646
PNG
(2-{[(R)-1-{[((S)-1-Carbamimidoyl-2-hydroxy-piperid...)
Show SMILES NC(=N)N1CCC(C[C@@H](NS(=O)(=O)Cc2ccccc2C(O)=O)C(=O)NCC(=O)N[C@H]2CCCN(C2O)C(N)=N)CC1
Show InChI InChI=1S/C25H39N9O7S/c26-24(27)33-10-7-15(8-11-33)12-19(32-42(40,41)14-16-4-1-2-5-17(16)23(38)39)21(36)30-13-20(35)31-18-6-3-9-34(22(18)37)25(28)29/h1-2,4-5,15,18-19,22,32,37H,3,6-14H2,(H3,26,27)(H3,28,29)(H,30,36)(H,31,35)(H,38,39)/t18-,19+,22?/m0/s1
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n/an/a 5.70n/an/an/an/an/an/a



Corvas International, Inc.

Curated by ChEMBL


Assay Description
In vitro inhibition of human plasmin.

Bioorg Med Chem Lett 10: 745-9 (2000)


BindingDB Entry DOI: 10.7270/Q2D50M5R
More data for this
Ligand-Target Pair
Prothrombin


(Homo sapiens (Human))		BDBM50054502
PNG
(CHEMBL140494 | N-((S)-3-Carbamimidoyl-2-hydroxy-cy...)
Show SMILES NC(=N)C1CCC[C@H](NC(=O)CN2CCC[C@H](NS(=O)(=O)Cc3ccccc3)C2=O)C1O
Show InChI InChI=1S/C21H31N5O5S/c22-20(23)15-8-4-9-16(19(15)28)24-18(27)12-26-11-5-10-17(21(26)29)25-32(30,31)13-14-6-2-1-3-7-14/h1-3,6-7,15-17,19,25,28H,4-5,8-13H2,(H3,22,23)(H,24,27)/t15?,16-,17-,19?/m0/s1
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n/an/a 6.20n/an/an/an/an/an/a



Corvas International, Inc.

Curated by ChEMBL


Assay Description
In vitro for inhibition of serine protease thrombin(FIIa).

J Med Chem 39: 4531-6 (1996)


Article DOI: 10.1021/jm960572n
BindingDB Entry DOI: 10.7270/Q28051QT
More data for this
Ligand-Target Pair
Prothrombin


(Homo sapiens (Human))		BDBM50071693
PNG
(CHEMBL38927 | CVS-1578 | N-((S)-1-Carbamimidoyl-2-...)
Show SMILES NC(=N)N1CCC[C@H](NC(=O)CN2CCC[C@H](NS(=O)(=O)Cc3ccccc3)C2=O)C1O
Show InChI InChI=1S/C20H30N6O5S/c21-20(22)26-11-5-8-15(19(26)29)23-17(27)12-25-10-4-9-16(18(25)28)24-32(30,31)13-14-6-2-1-3-7-14/h1-3,6-7,15-16,19,24,29H,4-5,8-13H2,(H3,21,22)(H,23,27)/t15-,16-,19?/m0/s1
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n/an/a 6.20n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
The compound was tested in vitro for inhibitory activity against Coagulation factor II

Bioorg Med Chem Lett 7: 2421-2426 (1997)


Article DOI: 10.1016/S0960-894X(97)00446-0
BindingDB Entry DOI: 10.7270/Q2X92B91
More data for this
Ligand-Target Pair
Prothrombin


(Homo sapiens (Human))		BDBM50071693
PNG
(CHEMBL38927 | CVS-1578 | N-((S)-1-Carbamimidoyl-2-...)
Show SMILES NC(=N)N1CCC[C@H](NC(=O)CN2CCC[C@H](NS(=O)(=O)Cc3ccccc3)C2=O)C1O
Show InChI InChI=1S/C20H30N6O5S/c21-20(22)26-11-5-8-15(19(26)29)23-17(27)12-25-10-4-9-16(18(25)28)24-32(30,31)13-14-6-2-1-3-7-14/h1-3,6-7,15-16,19,24,29H,4-5,8-13H2,(H3,21,22)(H,23,27)/t15-,16-,19?/m0/s1
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n/an/a 6.20n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory concentration of the compound required to inhibit human thrombin enzyme was determined

Bioorg Med Chem Lett 7: 1543-1548 (1997)


Article DOI: 10.1016/S0960-894X(97)00258-8
BindingDB Entry DOI: 10.7270/Q2HD7VNX
More data for this
Ligand-Target Pair
Prothrombin


(Homo sapiens (Human))		BDBM50076073
PNG
(1N-[1-amino(imino)methyl-6-hydroxy-(5S)-tetrahydro...)
Show SMILES NC(=N)N1CCC[C@H](NC(=O)CN2CCCC(NS(=O)(=O)Cc3ccccc3)C2=O)C1O
Show InChI InChI=1S/C20H30N6O5S/c21-20(22)26-11-5-8-15(19(26)29)23-17(27)12-25-10-4-9-16(18(25)28)24-32(30,31)13-14-6-2-1-3-7-14/h1-3,6-7,15-16,19,24,29H,4-5,8-13H2,(H3,21,22)(H,23,27)/t15-,16?,19?/m0/s1
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n/an/a 6.20n/an/an/an/an/an/a



Corvas International, Inc.

Curated by ChEMBL


Assay Description
Concentration required for the in vitro inhibitory activity against human enzyme, thrombin cleavage of the chromogenic substrate

Bioorg Med Chem Lett 9: 895-900 (1999)


BindingDB Entry DOI: 10.7270/Q2NS0T3Q
More data for this
Ligand-Target Pair
Prothrombin


(Homo sapiens (Human))		BDBM50076070
PNG
(1N-[1-amino(imino)methyl-6-hydroxy-(5S)-tetrahydro...)
Show SMILES CS(=O)(=O)Nc1c(CCc2ccccc2)ccn(CC(=O)N[C@H]2CCCN(C2O)C(N)=N)c1=O
Show InChI InChI=1S/C22H30N6O5S/c1-34(32,33)26-19-16(10-9-15-6-3-2-4-7-15)11-13-27(21(19)31)14-18(29)25-17-8-5-12-28(20(17)30)22(23)24/h2-4,6-7,11,13,17,20,26,30H,5,8-10,12,14H2,1H3,(H3,23,24)(H,25,29)/t17-,20?/m0/s1
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n/an/a 8n/an/an/an/an/an/a



Corvas International, Inc.

Curated by ChEMBL


Assay Description
Concentration required for the in vitro inhibitory activity against human enzyme, thrombin cleavage of the chromogenic substrate

Bioorg Med Chem Lett 9: 895-900 (1999)


BindingDB Entry DOI: 10.7270/Q2NS0T3Q
More data for this
Ligand-Target Pair
Serine protease 1


(Homo sapiens (Human))		BDBM50289560
PNG
(CHEMBL289389 | N-((S)-1-Carbamimidoyl-2-hydroxy-pi...)
Show SMILES Cc1ccc(NS(=O)(=O)Cc2ccccc2)c(=O)n1CC(=O)N[C@H]1CCCN(C1O)C(N)=N
Show InChI InChI=1S/C21H28N6O5S/c1-14-9-10-17(25-33(31,32)13-15-6-3-2-4-7-15)20(30)27(14)12-18(28)24-16-8-5-11-26(19(16)29)21(22)23/h2-4,6-7,9-10,16,19,25,29H,5,8,11-13H2,1H3,(H3,22,23)(H,24,28)/t16-,19?/m0/s1
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n/an/a 11n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory concentration of the compound required to inhibit human trypsin enzyme was determined

Bioorg Med Chem Lett 7: 1543-1548 (1997)


Article DOI: 10.1016/S0960-894X(97)00258-8
BindingDB Entry DOI: 10.7270/Q2HD7VNX
More data for this
Ligand-Target Pair
Prothrombin


(Homo sapiens (Human))		BDBM50054488
PNG
(CHEMBL138441 | CVS-1178 | N-((S)-1-Formyl-4-guanid...)
Show SMILES NC(=N)NCCC[C@H](NC(=O)CN1CCC[C@H](NS(=O)(=O)Cc2ccccc2)C1=O)C=O
Show InChI InChI=1S/C20H30N6O5S/c21-20(22)23-10-4-8-16(13-27)24-18(28)12-26-11-5-9-17(19(26)29)25-32(30,31)14-15-6-2-1-3-7-15/h1-3,6-7,13,16-17,25H,4-5,8-12,14H2,(H,24,28)(H4,21,22,23)/t16-,17-/m0/s1
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n/an/a 12.4n/an/an/an/an/an/a



Corvas International Inc.

Curated by ChEMBL


Assay Description
Compound was evaluated for inhibition of amidolytic activity for chromogenic substrate thrombin F11a.

J Med Chem 39: 4527-30 (1996)


Article DOI: 10.1021/jm960607j
BindingDB Entry DOI: 10.7270/Q2CR5SFV
More data for this
Ligand-Target Pair
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