Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Vasopressin V2 receptor (Homo sapiens (Human)) | BDBM35666 (BMC173130 Compound 1t | benzazepinelidene acetamid...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | KEGG PC cid PC sid UniChem Similars | Article PubMed | 9.70 | -45.4 | n/a | n/a | n/a | n/a | n/a | 7.4 | 23 |
Astellas Pharma Inc. | Assay Description The affinities of test compounds for human V2 receptor were evaluated by the radioligand binding study using membrane fractions isolated from CHO cel... | Bioorg Med Chem 17: 8161-7 (2009) Article DOI: 10.1016/j.bmc.2009.10.038 BindingDB Entry DOI: 10.7270/Q28K77DW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Vasopressin V1a receptor (Homo sapiens (Human)) | BDBM35669 (benzazepinelidene acetamide derivative, 1d) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | KEGG PC cid PC sid UniChem Similars | Article PubMed | 13 | -44.7 | n/a | n/a | n/a | n/a | n/a | 7.4 | 23 |
Astellas Pharma Inc. | Assay Description Chinese hamster ovary (CHO) cells stably expressing human V1a receptors. Cells were washed with phosphate buffered saline, and then collected in ice-... | Bioorg Med Chem 17: 8161-7 (2009) Article DOI: 10.1016/j.bmc.2009.10.038 BindingDB Entry DOI: 10.7270/Q28K77DW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Vasopressin V2 receptor (Homo sapiens (Human)) | BDBM35669 (benzazepinelidene acetamide derivative, 1d) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | KEGG PC cid PC sid UniChem Similars | Article PubMed | 13 | -44.7 | n/a | n/a | n/a | n/a | n/a | 7.4 | 23 |
Astellas Pharma Inc. | Assay Description The affinities of test compounds for human V2 receptor were evaluated by the radioligand binding study using membrane fractions isolated from CHO cel... | Bioorg Med Chem 17: 8161-7 (2009) Article DOI: 10.1016/j.bmc.2009.10.038 BindingDB Entry DOI: 10.7270/Q28K77DW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Vasopressin V2 receptor (Homo sapiens (Human)) | BDBM35672 (benzazepinelidene acetamide derivative, 1g) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | KEGG PC cid PC sid UniChem Similars | Article PubMed | 14 | -44.5 | n/a | n/a | n/a | n/a | n/a | 7.4 | 23 |
Astellas Pharma Inc. | Assay Description The affinities of test compounds for human V2 receptor were evaluated by the radioligand binding study using membrane fractions isolated from CHO cel... | Bioorg Med Chem 17: 8161-7 (2009) Article DOI: 10.1016/j.bmc.2009.10.038 BindingDB Entry DOI: 10.7270/Q28K77DW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Vasopressin V2 receptor (Homo sapiens (Human)) | BDBM35671 (benzazepinelidene acetamide derivative, 1f) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | KEGG PC cid PC sid UniChem Similars | Article PubMed | 14 | -44.5 | n/a | n/a | n/a | n/a | n/a | 7.4 | 23 |
Astellas Pharma Inc. | Assay Description The affinities of test compounds for human V2 receptor were evaluated by the radioligand binding study using membrane fractions isolated from CHO cel... | Bioorg Med Chem 17: 8161-7 (2009) Article DOI: 10.1016/j.bmc.2009.10.038 BindingDB Entry DOI: 10.7270/Q28K77DW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Vasopressin V2 receptor (Homo sapiens (Human)) | BDBM35670 (benzazepinelidene acetamide derivative, 1e) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | KEGG PC cid PC sid UniChem Similars | Article PubMed | 16 | -44.2 | n/a | n/a | n/a | n/a | n/a | 7.4 | 23 |
Astellas Pharma Inc. | Assay Description The affinities of test compounds for human V2 receptor were evaluated by the radioligand binding study using membrane fractions isolated from CHO cel... | Bioorg Med Chem 17: 8161-7 (2009) Article DOI: 10.1016/j.bmc.2009.10.038 BindingDB Entry DOI: 10.7270/Q28K77DW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Vasopressin V1a receptor (Homo sapiens (Human)) | BDBM35671 (benzazepinelidene acetamide derivative, 1f) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | KEGG PC cid PC sid UniChem Similars | Article PubMed | 17 | -44.0 | n/a | n/a | n/a | n/a | n/a | 7.4 | 23 |
Astellas Pharma Inc. | Assay Description Chinese hamster ovary (CHO) cells stably expressing human V1a receptors. Cells were washed with phosphate buffered saline, and then collected in ice-... | Bioorg Med Chem 17: 8161-7 (2009) Article DOI: 10.1016/j.bmc.2009.10.038 BindingDB Entry DOI: 10.7270/Q28K77DW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Vasopressin V1a receptor (Homo sapiens (Human)) | BDBM35666 (BMC173130 Compound 1t | benzazepinelidene acetamid...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | KEGG PC cid PC sid UniChem Similars | Article PubMed | 28 | -42.8 | n/a | n/a | n/a | n/a | n/a | 7.4 | 23 |
Astellas Pharma Inc. | Assay Description Chinese hamster ovary (CHO) cells stably expressing human V1a receptors. Cells were washed with phosphate buffered saline, and then collected in ice-... | Bioorg Med Chem 17: 8161-7 (2009) Article DOI: 10.1016/j.bmc.2009.10.038 BindingDB Entry DOI: 10.7270/Q28K77DW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Macrophage migration inhibitory factor (Homo sapiens (Human)) | BDBM50095997 (3',4',7-trihydroxyisoflavone | CHEMBL13486) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | MMDB PDB PubMed | 38 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Yamanouchi Pharmaceutical Company Ltd. Curated by ChEMBL | Assay Description Inhibitory activity against tautomerase macrophage migration inhibitory factor (MIF) | J Med Chem 44: 540-7 (2001) BindingDB Entry DOI: 10.7270/Q2W66MGR | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Vasopressin V1a receptor (Homo sapiens (Human)) | BDBM35670 (benzazepinelidene acetamide derivative, 1e) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | KEGG PC cid PC sid UniChem Similars | Article PubMed | 39 | -42.0 | n/a | n/a | n/a | n/a | n/a | 7.4 | 23 |
Astellas Pharma Inc. | Assay Description Chinese hamster ovary (CHO) cells stably expressing human V1a receptors. Cells were washed with phosphate buffered saline, and then collected in ice-... | Bioorg Med Chem 17: 8161-7 (2009) Article DOI: 10.1016/j.bmc.2009.10.038 BindingDB Entry DOI: 10.7270/Q28K77DW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Vasopressin V1a receptor (Homo sapiens (Human)) | BDBM35672 (benzazepinelidene acetamide derivative, 1g) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | KEGG PC cid PC sid UniChem Similars | Article PubMed | 43 | -41.8 | n/a | n/a | n/a | n/a | n/a | 7.4 | 23 |
Astellas Pharma Inc. | Assay Description Chinese hamster ovary (CHO) cells stably expressing human V1a receptors. Cells were washed with phosphate buffered saline, and then collected in ice-... | Bioorg Med Chem 17: 8161-7 (2009) Article DOI: 10.1016/j.bmc.2009.10.038 BindingDB Entry DOI: 10.7270/Q28K77DW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Vasopressin V2 receptor (Homo sapiens (Human)) | BDBM35668 (benzazepinelidene acetamide derivative, 1c) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | KEGG PC cid PC sid UniChem Similars | Article PubMed | 78 | -40.3 | n/a | n/a | n/a | n/a | n/a | 7.4 | 23 |
Astellas Pharma Inc. | Assay Description The affinities of test compounds for human V2 receptor were evaluated by the radioligand binding study using membrane fractions isolated from CHO cel... | Bioorg Med Chem 17: 8161-7 (2009) Article DOI: 10.1016/j.bmc.2009.10.038 BindingDB Entry DOI: 10.7270/Q28K77DW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Vasopressin V1a receptor (Homo sapiens (Human)) | BDBM35668 (benzazepinelidene acetamide derivative, 1c) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | KEGG PC cid PC sid UniChem Similars | Article PubMed | 170 | -38.4 | n/a | n/a | n/a | n/a | n/a | 7.4 | 23 |
Astellas Pharma Inc. | Assay Description Chinese hamster ovary (CHO) cells stably expressing human V1a receptors. Cells were washed with phosphate buffered saline, and then collected in ice-... | Bioorg Med Chem 17: 8161-7 (2009) Article DOI: 10.1016/j.bmc.2009.10.038 BindingDB Entry DOI: 10.7270/Q28K77DW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Macrophage migration inhibitory factor (Homo sapiens (Human)) | BDBM50096004 (7-Hydroxy-3-[4-(2-oxo-2H-chromen-3-yl)-thiazol-2-y...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 280 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Yamanouchi Pharmaceutical Company Ltd. Curated by ChEMBL | Assay Description Inhibitory activity against tautomerase macrophage migration inhibitory factor (MIF) | J Med Chem 44: 540-7 (2001) BindingDB Entry DOI: 10.7270/Q2W66MGR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Macrophage migration inhibitory factor (Homo sapiens (Human)) | BDBM50096003 (7-Hydroxy-3-phenyl-chromen-2-one | 7-hydroxy-3-phe...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | PubMed | 470 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Yamanouchi Pharmaceutical Company Ltd. Curated by ChEMBL | Assay Description Inhibitory activity against tautomerase macrophage migration inhibitory factor (MIF) | J Med Chem 44: 540-7 (2001) BindingDB Entry DOI: 10.7270/Q2W66MGR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Macrophage migration inhibitory factor (Homo sapiens (Human)) | BDBM50096001 (7-Hydroxy-3-pyrazolo[1,5-a]pyridin-2-yl-chromen-2-...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | PubMed | 500 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Yamanouchi Pharmaceutical Company Ltd. Curated by ChEMBL | Assay Description Inhibitory activity against tautomerase macrophage migration inhibitory factor (MIF) | J Med Chem 44: 540-7 (2001) BindingDB Entry DOI: 10.7270/Q2W66MGR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Macrophage migration inhibitory factor (Homo sapiens (Human)) | BDBM50095993 (7-Hydroxy-2-oxo-2H-chromene-3-carbothioic acid ami...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem | PubMed | 550 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Yamanouchi Pharmaceutical Company Ltd. Curated by ChEMBL | Assay Description Inhibitory activity against tautomerase macrophage migration inhibitory factor (MIF) | J Med Chem 44: 540-7 (2001) BindingDB Entry DOI: 10.7270/Q2W66MGR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Macrophage migration inhibitory factor (Homo sapiens (Human)) | BDBM50096002 (3-(4-Benzo[1,3]dioxol-5-yl-thiazol-2-yl)-7-hydroxy...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents | PubMed | 1.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Yamanouchi Pharmaceutical Company Ltd. Curated by ChEMBL | Assay Description Inhibitory activity against tautomerase macrophage migration inhibitory factor (MIF) | J Med Chem 44: 540-7 (2001) BindingDB Entry DOI: 10.7270/Q2W66MGR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Macrophage migration inhibitory factor (Homo sapiens (Human)) | BDBM50096007 (2-Oxo-2H-chromene-3-carboxylic acid 2-oxo-2-phenyl...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | PubMed | 1.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Yamanouchi Pharmaceutical Company Ltd. Curated by ChEMBL | Assay Description Inhibitory activity against tautomerase macrophage migration inhibitory factor (MIF) | J Med Chem 44: 540-7 (2001) BindingDB Entry DOI: 10.7270/Q2W66MGR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Macrophage migration inhibitory factor (Homo sapiens (Human)) | BDBM50096006 (7-Hydroxy-3-(2-methyl-thiazol-4-yl)-chromen-2-one ...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 2.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Yamanouchi Pharmaceutical Company Ltd. Curated by ChEMBL | Assay Description Inhibitory activity against tautomerase macrophage migration inhibitory factor (MIF) | J Med Chem 44: 540-7 (2001) BindingDB Entry DOI: 10.7270/Q2W66MGR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Macrophage migration inhibitory factor (Homo sapiens (Human)) | BDBM50096000 (3-(2-Fluoro-4-hydroxy-phenyl)-acrylic acid anion) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | PubMed | 2.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Yamanouchi Pharmaceutical Company Ltd. Curated by ChEMBL | Assay Description Inhibitory activity against tautomerase macrophage migration inhibitory factor (MIF) | J Med Chem 44: 540-7 (2001) BindingDB Entry DOI: 10.7270/Q2W66MGR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Macrophage migration inhibitory factor (Homo sapiens (Human)) | BDBM50095994 (3-Cyano-7-hydroxycoumarin (2) | 7-Hydroxy-2-oxo-2H...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars | PubMed | 2.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Yamanouchi Pharmaceutical Company Ltd. Curated by ChEMBL | Assay Description Inhibitory activity against tautomerase macrophage migration inhibitory factor (MIF) | J Med Chem 44: 540-7 (2001) BindingDB Entry DOI: 10.7270/Q2W66MGR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Macrophage migration inhibitory factor (Homo sapiens (Human)) | BDBM50096005 (7-Hydroxy-3-(4-methyl-thiazol-2-yl)-chromen-2-one ...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 3.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Yamanouchi Pharmaceutical Company Ltd. Curated by ChEMBL | Assay Description Inhibitory activity against tautomerase macrophage migration inhibitory factor (MIF) | J Med Chem 44: 540-7 (2001) BindingDB Entry DOI: 10.7270/Q2W66MGR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Macrophage migration inhibitory factor (Homo sapiens (Human)) | BDBM50096008 (3-Acetyl-7-hydroxy-chromen-2-one | 3-acetyl-7-hydr...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 4.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Yamanouchi Pharmaceutical Company Ltd. Curated by ChEMBL | Assay Description Inhibitory activity against tautomerase macrophage migration inhibitory factor (MIF) | J Med Chem 44: 540-7 (2001) BindingDB Entry DOI: 10.7270/Q2W66MGR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Macrophage migration inhibitory factor (Homo sapiens (Human)) | BDBM50095996 (3-(7-Hydroxy-2-oxo-2H-chromen-3-yl)-3-oxo-propioni...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem | PubMed | 5.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Yamanouchi Pharmaceutical Company Ltd. Curated by ChEMBL | Assay Description Inhibitory activity against tautomerase macrophage migration inhibitory factor (MIF) | J Med Chem 44: 540-7 (2001) BindingDB Entry DOI: 10.7270/Q2W66MGR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Macrophage migration inhibitory factor (Homo sapiens (Human)) | BDBM50096009 (3-(4-Dimethylamino-benzylidene)-chroman-2,4-dione ...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | PubMed | 6.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Yamanouchi Pharmaceutical Company Ltd. Curated by ChEMBL | Assay Description Inhibitory activity against tautomerase macrophage migration inhibitory factor (MIF) | J Med Chem 44: 540-7 (2001) BindingDB Entry DOI: 10.7270/Q2W66MGR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Macrophage migration inhibitory factor (Homo sapiens (Human)) | BDBM50095995 (7-HYDROXY-2-OXO-CHROMENE-3-CARBOXYLIC ACID ETHYL E...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | DrugBank MMDB PDB PubMed | 7.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Yamanouchi Pharmaceutical Company Ltd. Curated by ChEMBL | Assay Description Inhibitory activity against tautomerase macrophage migration inhibitory factor (MIF) | J Med Chem 44: 540-7 (2001) BindingDB Entry DOI: 10.7270/Q2W66MGR | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Transient receptor potential cation channel subfamily V member 4 (Rattus norvegicus) | BDBM50521995 (CHEMBL4578182) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 0.320 | n/a | n/a | n/a | n/a | n/a | n/a |
Astellas Pharma Inc. Curated by ChEMBL | Assay Description Inhibition of rat TRPV4 expressed in HEK293 cells assessed as reduction in Ca2+ influx incubated for 30 mins by Fluo4-AM dye based | Bioorg Med Chem 27: 3775-3787 (2019) Article DOI: 10.1016/j.bmc.2019.05.041 BindingDB Entry DOI: 10.7270/Q2KK9G6N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Signal transducer and activator of transcription 6 (Homo sapiens (Human)) | BDBM50304425 (2-(4-morpholinophenylamino)-4-(2,3,6-trifluorobenz...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 0.700 | n/a | n/a | n/a | n/a | n/a | n/a |
Astellas Pharma Inc. Curated by ChEMBL | Assay Description Inhibition of STAT6 in IL4-stimulated human FW4 reporter cells by luciferase assay | Bioorg Med Chem 17: 6926-36 (2009) Article DOI: 10.1016/j.bmc.2009.08.021 BindingDB Entry DOI: 10.7270/Q2RV0NS7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Signal transducer and activator of transcription 6 (Homo sapiens (Human)) | BDBM50243934 (2-[(4-Morpholin-4-ylphenyl)amino]-4-[(2,3,6-triflu...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 0.700 | n/a | n/a | n/a | n/a | n/a | n/a |
Astellas Pharma Inc. Curated by ChEMBL | Assay Description Inhibition of STAT6 activation (unknown origin) in FW4 reporter cells | Bioorg Med Chem 16: 6509-21 (2008) Article DOI: 10.1016/j.bmc.2008.05.031 BindingDB Entry DOI: 10.7270/Q2VD6Z7H | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transient receptor potential cation channel subfamily V member 4 (Rattus norvegicus) | BDBM50522021 (CHEMBL4465116) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 0.730 | n/a | n/a | n/a | n/a | n/a | n/a |
Astellas Pharma Inc. Curated by ChEMBL | Assay Description Inhibition of rat TRPV4 expressed in HEK293 cells assessed as reduction in Ca2+ influx incubated for 30 mins by Fluo4-AM dye based | Bioorg Med Chem 27: 3775-3787 (2019) Article DOI: 10.1016/j.bmc.2019.05.041 BindingDB Entry DOI: 10.7270/Q2KK9G6N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transient receptor potential cation channel subfamily V member 4 (Homo sapiens (Human)) | BDBM50521996 (CHEMBL4459940) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 0.850 | n/a | n/a | n/a | n/a | n/a | n/a |
Astellas Pharma Inc. Curated by ChEMBL | Assay Description Inhibition of human TRPV4 expressed in HEK293 cells assessed as reduction in Ca2+ influx incubated for 30 mins by Fluo4-AM dye based | Bioorg Med Chem 27: 3775-3787 (2019) Article DOI: 10.1016/j.bmc.2019.05.041 BindingDB Entry DOI: 10.7270/Q2KK9G6N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transient receptor potential cation channel subfamily V member 4 (Rattus norvegicus) | BDBM50521996 (CHEMBL4459940) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Astellas Pharma Inc. Curated by ChEMBL | Assay Description Inhibition of rat TRPV4 expressed in HEK293 cells assessed as reduction in Ca2+ influx incubated for 30 mins by Fluo4-AM dye based | Bioorg Med Chem 27: 3775-3787 (2019) Article DOI: 10.1016/j.bmc.2019.05.041 BindingDB Entry DOI: 10.7270/Q2KK9G6N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transient receptor potential cation channel subfamily V member 4 (Homo sapiens (Human)) | BDBM50521995 (CHEMBL4578182) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Astellas Pharma Inc. Curated by ChEMBL | Assay Description Inhibition of human TRPV4 expressed in HEK293 cells assessed as reduction in Ca2+ influx incubated for 30 mins by Fluo4-AM dye based | Bioorg Med Chem 27: 3775-3787 (2019) Article DOI: 10.1016/j.bmc.2019.05.041 BindingDB Entry DOI: 10.7270/Q2KK9G6N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Signal transducer and activator of transcription 6 (Homo sapiens (Human)) | BDBM50244291 (4-[(2-Fluorobenzyl)amino]-2-[(4-morpholin-4-ylphen...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Astellas Pharma Inc. Curated by ChEMBL | Assay Description Inhibition of STAT6 activation (unknown origin) in FW4 reporter cells | Bioorg Med Chem 16: 6509-21 (2008) Article DOI: 10.1016/j.bmc.2008.05.031 BindingDB Entry DOI: 10.7270/Q2VD6Z7H | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D-amino-acid oxidase (Homo sapiens (Human)) | BDBM50431067 (CHEMBL2338797 | US10202399, Example 18 | US1046366...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Astellas Pharma Inc. Curated by ChEMBL | Assay Description Inhibition of human recombinant DAAO after 30 mins by plate reader analysis | J Med Chem 56: 3582-92 (2013) Article DOI: 10.1021/jm400095b BindingDB Entry DOI: 10.7270/Q2HT2QPZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D-amino-acid oxidase (Homo sapiens (Human)) | BDBM50260725 (4H-thieno[3,2-b]pyrrole-5-carboxylic acid | CHEMBL...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents | PDB Article PubMed | n/a | n/a | 1.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Astellas Pharma Inc. Curated by ChEMBL | Assay Description Inhibition of human recombinant DAAO after 30 mins by plate reader analysis | J Med Chem 56: 3582-92 (2013) Article DOI: 10.1021/jm400095b BindingDB Entry DOI: 10.7270/Q2HT2QPZ | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
D-amino-acid oxidase (Homo sapiens (Human)) | BDBM50431083 (CHEMBL2338803 | US10202399, Example 24 | US1046366...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Astellas Pharma Inc. Curated by ChEMBL | Assay Description Inhibition of human recombinant DAAO after 30 mins by plate reader analysis | J Med Chem 56: 3582-92 (2013) Article DOI: 10.1021/jm400095b BindingDB Entry DOI: 10.7270/Q2HT2QPZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Signal transducer and activator of transcription 6 (Homo sapiens (Human)) | BDBM50243884 (4-[(2,5-Difluorobenzyl)amino]-2-[(4-morpholin-4-yl...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Astellas Pharma Inc. Curated by ChEMBL | Assay Description Inhibition of STAT6 activation (unknown origin) in FW4 reporter cells | Bioorg Med Chem 16: 6509-21 (2008) Article DOI: 10.1016/j.bmc.2008.05.031 BindingDB Entry DOI: 10.7270/Q2VD6Z7H | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Signal transducer and activator of transcription 6 (Homo sapiens (Human)) | BDBM50244292 (4-[(3-Fluorobenzyl)amino]-2-[(4-morpholin-4-ylphen...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Astellas Pharma Inc. Curated by ChEMBL | Assay Description Inhibition of STAT6 activation (unknown origin) in FW4 reporter cells | Bioorg Med Chem 16: 6509-21 (2008) Article DOI: 10.1016/j.bmc.2008.05.031 BindingDB Entry DOI: 10.7270/Q2VD6Z7H | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Signal transducer and activator of transcription 6 (Homo sapiens (Human)) | BDBM50243933 (2-[(4-Morpholin-4-ylphenyl)amino]-4-[(2,3,5-triflu...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Astellas Pharma Inc. Curated by ChEMBL | Assay Description Inhibition of STAT6 activation (unknown origin) in FW4 reporter cells | Bioorg Med Chem 16: 6509-21 (2008) Article DOI: 10.1016/j.bmc.2008.05.031 BindingDB Entry DOI: 10.7270/Q2VD6Z7H | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transient receptor potential cation channel subfamily V member 4 (Homo sapiens (Human)) | BDBM50522014 (CHEMBL4460657) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Astellas Pharma Inc. Curated by ChEMBL | Assay Description Inhibition of human TRPV4 expressed in HEK293 cells assessed as reduction in Ca2+ influx incubated for 30 mins by Fluo4-AM dye based | Bioorg Med Chem 27: 3775-3787 (2019) Article DOI: 10.1016/j.bmc.2019.05.041 BindingDB Entry DOI: 10.7270/Q2KK9G6N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Signal transducer and activator of transcription 6 (Homo sapiens (Human)) | BDBM50304429 (2-[4-(4-{[7-(3,5-Difluorobenzyl)-7H-pyrrolo[2,3-d]...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Astellas Pharma Inc. Curated by ChEMBL | Assay Description Inhibition of STAT6 in IL4-stimulated human FW4 reporter cells by luciferase assay | Bioorg Med Chem 17: 6926-36 (2009) Article DOI: 10.1016/j.bmc.2009.08.021 BindingDB Entry DOI: 10.7270/Q2RV0NS7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D-amino-acid oxidase (Mus musculus) | BDBM50431067 (CHEMBL2338797 | US10202399, Example 18 | US1046366...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Astellas Pharma Inc. Curated by ChEMBL | Assay Description Inhibition of mouse full length DAAO overexpressed in HEK293 cells after 30 mins by plate reader analysis | J Med Chem 56: 3582-92 (2013) Article DOI: 10.1021/jm400095b BindingDB Entry DOI: 10.7270/Q2HT2QPZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D-amino-acid oxidase (Mus musculus) | BDBM50431074 (CHEMBL2338790 | US10463663, Example 27 | US1112982...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Astellas Pharma Inc. Curated by ChEMBL | Assay Description Inhibition of mouse full length DAAO overexpressed in HEK293 cells after 30 mins by plate reader analysis | J Med Chem 56: 3582-92 (2013) Article DOI: 10.1021/jm400095b BindingDB Entry DOI: 10.7270/Q2HT2QPZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D-amino-acid oxidase (Homo sapiens (Human)) | BDBM50431069 (CHEMBL2338795 | US10202399, Example 27 | US1046366...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Astellas Pharma Inc. Curated by ChEMBL | Assay Description Inhibition of human recombinant DAAO after 30 mins by plate reader analysis | J Med Chem 56: 3582-92 (2013) Article DOI: 10.1021/jm400095b BindingDB Entry DOI: 10.7270/Q2HT2QPZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human)) | BDBM50520336 (CHEMBL4470042) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Astellas Pharma Inc. Curated by ChEMBL | Assay Description Inhibition of human PDE10A using cAMP as substrate preincubated for 30 mins followed by substrate addition and measured after 60 mins by HTRF detecti... | Bioorg Med Chem 27: 3692-3706 (2019) Article DOI: 10.1016/j.bmc.2019.07.010 BindingDB Entry DOI: 10.7270/Q2MK6H9K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D-amino-acid oxidase (Homo sapiens (Human)) | BDBM50431065 (CHEMBL2338799 | US10202399, Example 16) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Astellas Pharma Inc. Curated by ChEMBL | Assay Description Inhibition of human recombinant DAAO after 30 mins by plate reader analysis | J Med Chem 56: 3582-92 (2013) Article DOI: 10.1021/jm400095b BindingDB Entry DOI: 10.7270/Q2HT2QPZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Signal transducer and activator of transcription 6 (Homo sapiens (Human)) | BDBM50243882 (4-[(2,3-Difluorobenzyl)amino]-2-[(4-morpholin-4-yl...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Astellas Pharma Inc. Curated by ChEMBL | Assay Description Inhibition of STAT6 activation (unknown origin) in FW4 reporter cells | Bioorg Med Chem 16: 6509-21 (2008) Article DOI: 10.1016/j.bmc.2008.05.031 BindingDB Entry DOI: 10.7270/Q2VD6Z7H | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Signal transducer and activator of transcription 6 (Homo sapiens (Human)) | BDBM50243885 (4-[(2,6-Difluorobenzyl)amino]-2-[(4-morpholin-4-yl...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Astellas Pharma Inc. Curated by ChEMBL | Assay Description Inhibition of STAT6 activation (unknown origin) in FW4 reporter cells | Bioorg Med Chem 16: 6509-21 (2008) Article DOI: 10.1016/j.bmc.2008.05.031 BindingDB Entry DOI: 10.7270/Q2VD6Z7H | |||||||||||
More data for this Ligand-Target Pair |
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