Found 12 hits with Last Name = 'orvos' and Initial = 'p' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
G protein-activated inward rectifier potassium channel 4
(Homo sapiens (Human)) | BDBM50468101
(CHEMBL4282752)Show SMILES [H][C@@]12\C=C(C)\[C@@H](C[C@@H](OC(C)=O)C(C)(C)\C=C\[C@H](C)[C@H](OC(C)=O)[C@@]1(O)C[C@H](C)[C@@H]2OC(=O)c1ccccc1)OC(=O)C(\C)=C\C |r,c:2,t:15| Show InChI InChI=1S/C36H48O9/c1-10-21(2)33(39)44-29-19-30(42-25(6)37)35(8,9)17-16-22(3)32(43-26(7)38)36(41)20-24(5)31(28(36)18-23(29)4)45-34(40)27-14-12-11-13-15-27/h10-18,22,24,28-32,41H,19-20H2,1-9H3/b17-16+,21-10+,23-18+/t22-,24-,28-,29+,30+,31-,32-,36+/m0/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.31E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Rytmion Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of GIRK-1/4 channel (unknown origin) expressed in HEK293 cells by automated patch clamp method |
J Nat Prod 81: 2483-2492 (2018)
Article DOI: 10.1021/acs.jnatprod.8b00500
BindingDB Entry DOI: 10.7270/Q2765J1T |
More data for this
Ligand-Target Pair | |
G protein-activated inward rectifier potassium channel 4
(Homo sapiens (Human)) | BDBM50468103
(CHEMBL4295025)Show SMILES [H][C@@]12C[C@@H](C)[C@@]34C=C(C)[C@H](OC(=O)C(\C)=C/C)[C@@]3(O)[C@H](O)C(C)=C[C@]([H])(C4=O)[C@]1([H])C2(C)COC(=O)C(\C)=C/C |r,c:23,t:6| Show InChI InChI=1S/C30H40O7/c1-9-15(3)26(33)36-14-28(8)21-12-19(7)29-13-18(6)25(37-27(34)16(4)10-2)30(29,35)23(31)17(5)11-20(22(21)28)24(29)32/h9-11,13,19-23,25,31,35H,12,14H2,1-8H3/b15-9-,16-10-/t19-,20+,21-,22+,23-,25+,28?,29-,30+/m1/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.45E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Rytmion Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of GIRK-1/4 channel (unknown origin) expressed in HEK293 cells by automated patch clamp method |
J Nat Prod 81: 2483-2492 (2018)
Article DOI: 10.1021/acs.jnatprod.8b00500
BindingDB Entry DOI: 10.7270/Q2765J1T |
More data for this
Ligand-Target Pair | |
G protein-activated inward rectifier potassium channel 4
(Homo sapiens (Human)) | BDBM50468100
(CHEMBL4290637)Show SMILES [H][C@@]12\C=C(C)\[C@H](OC(=O)C(\C)=C\C)[C@H](OC(C)=O)[C@@H](OC(C)=O)C(C)(C)\C=C\[C@H](C)[C@H](OC(C)=O)[C@@]1(O)C[C@H](C)[C@@H]2OC(=O)c1ccccc1 |r,c:2,t:26| Show InChI InChI=1S/C38H50O11/c1-11-21(2)35(42)49-31-23(4)19-29-30(48-36(43)28-15-13-12-14-16-28)24(5)20-38(29,44)33(46-26(7)40)22(3)17-18-37(9,10)34(47-27(8)41)32(31)45-25(6)39/h11-19,22,24,29-34,44H,20H2,1-10H3/b18-17+,21-11+,23-19+/t22-,24-,29-,30-,31-,32-,33-,34+,38+/m0/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Rytmion Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of GIRK-1/4 channel (unknown origin) expressed in HEK293 cells by automated patch clamp method |
J Nat Prod 81: 2483-2492 (2018)
Article DOI: 10.1021/acs.jnatprod.8b00500
BindingDB Entry DOI: 10.7270/Q2765J1T |
More data for this
Ligand-Target Pair | |
G protein-activated inward rectifier potassium channel 4
(Homo sapiens (Human)) | BDBM50468102
(CHEMBL4281441)Show SMILES [H][C@@]12\C=C(C)\[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H](OC(C)=O)C(C)(C)\C=C\[C@H](C)[C@H](OC(C)=O)[C@@]1(O)C[C@H](C)[C@@H]2OC(=O)c1ccccc1 |r,c:2,t:23| Show InChI InChI=1S/C35H46O11/c1-19-15-16-34(8,9)32(45-25(7)39)30(43-23(5)37)29(42-22(4)36)20(2)17-27-28(46-33(40)26-13-11-10-12-14-26)21(3)18-35(27,41)31(19)44-24(6)38/h10-17,19,21,27-32,41H,18H2,1-9H3/b16-15+,20-17+/t19-,21-,27-,28-,29-,30-,31-,32+,35+/m0/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.69E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Rytmion Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of GIRK-1/4 channel (unknown origin) expressed in HEK293 cells by automated patch clamp method |
J Nat Prod 81: 2483-2492 (2018)
Article DOI: 10.1021/acs.jnatprod.8b00500
BindingDB Entry DOI: 10.7270/Q2765J1T |
More data for this
Ligand-Target Pair | |
G protein-activated inward rectifier potassium channel 4
(Homo sapiens (Human)) | BDBM50202477
(CHEMBL3955249)Show SMILES [H][C@]12[C@@H](OC(=O)c3ccccc3)[C@@H](C)C[C@]1(OC(C)=O)[C@@H](OC(C)=O)[C@]1(C)OC[C@@]3([C@@H]2OC(C)=O)C(=O)C=C[C@@H]([C@@]13[H])C(C)(C)OC(C)=O |r,c:40| Show InChI InChI=1S/C35H42O12/c1-18-16-35(47-22(5)39)26(27(18)45-30(41)23-12-10-9-11-13-23)29(43-19(2)36)34-17-42-33(8,31(35)44-20(3)37)28(34)24(14-15-25(34)40)32(6,7)46-21(4)38/h9-15,18,24,26-29,31H,16-17H2,1-8H3/t18-,24-,26+,27-,28-,29+,31-,33+,34+,35+/m0/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Rytmion Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of GTPgammaS-induced activation of GIRK1/4 (unknown origin) expressed in HEK293 cells assessed as decrease in channel current after 2 mins... |
J Nat Prod 79: 1990-2004 (2016)
Article DOI: 10.1021/acs.jnatprod.6b00260
BindingDB Entry DOI: 10.7270/Q2CC12NJ |
More data for this
Ligand-Target Pair | |
G protein-activated inward rectifier potassium channel 4
(Homo sapiens (Human)) | BDBM50468097
(Euphornin)Show SMILES [H][C@@]12\C=C(C)\[C@@H](C[C@@H](OC(C)=O)C(C)(C)\C=C\[C@H](C)[C@H](OC(C)=O)[C@@]1(O)C[C@H](C)[C@@H]2OC(=O)c1ccccc1)OC(C)=O |r,c:2,t:15| Show InChI InChI=1S/C33H44O9/c1-19-14-15-32(7,8)28(40-23(5)35)17-27(39-22(4)34)20(2)16-26-29(42-31(37)25-12-10-9-11-13-25)21(3)18-33(26,38)30(19)41-24(6)36/h9-16,19,21,26-30,38H,17-18H2,1-8H3/b15-14+,20-16+/t19-,21-,26-,27+,28+,29-,30-,33+/m0/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 2.63E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Rytmion Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of GIRK-1/4 channel (unknown origin) expressed in HEK293 cells by automated patch clamp method |
J Nat Prod 81: 2483-2492 (2018)
Article DOI: 10.1021/acs.jnatprod.8b00500
BindingDB Entry DOI: 10.7270/Q2765J1T |
More data for this
Ligand-Target Pair | |
G protein-activated inward rectifier potassium channel 4
(Homo sapiens (Human)) | BDBM50468099
(CHEMBL4289317)Show SMILES [H][C@@]12\C=C(C)\[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H](OC(C)=O)C(C)(C)\C=C\[C@H](C)[C@H](O)[C@]1(C[C@H](C)[C@@H]2OC(=O)c1ccccc1)OC(C)=O |r,c:2,t:23| Show InChI InChI=1S/C35H46O11/c1-19-15-16-34(8,9)32(44-24(6)38)30(43-23(5)37)29(42-22(4)36)20(2)17-27-28(45-33(41)26-13-11-10-12-14-26)21(3)18-35(27,31(19)40)46-25(7)39/h10-17,19,21,27-32,40H,18H2,1-9H3/b16-15+,20-17+/t19-,21-,27-,28-,29-,30-,31-,32+,35+/m0/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 3.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Rytmion Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of GIRK-1/4 channel (unknown origin) expressed in HEK293 cells by automated patch clamp method |
J Nat Prod 81: 2483-2492 (2018)
Article DOI: 10.1021/acs.jnatprod.8b00500
BindingDB Entry DOI: 10.7270/Q2765J1T |
More data for this
Ligand-Target Pair | |
G protein-activated inward rectifier potassium channel 4
(Homo sapiens (Human)) | BDBM50202479
(CHEBI:69714 | Euphorbiaproliferin C)Show SMILES [H][C@]12[C@@H](OC(=O)C(C)C)[C@@H](C)C[C@]1(OC(C)=O)[C@@H](OC(C)=O)[C@]1(C)OC[C@@]3([C@@H]2OC(C)=O)C(=O)C=C[C@@H]([C@@]13[H])C(C)(C)OC(C)=O |r,c:36| Show InChI InChI=1S/C32H44O12/c1-15(2)27(38)42-24-16(3)13-32(44-20(7)36)23(24)26(40-17(4)33)31-14-39-30(10,28(32)41-18(5)34)25(31)21(11-12-22(31)37)29(8,9)43-19(6)35/h11-12,15-16,21,23-26,28H,13-14H2,1-10H3/t16-,21-,23+,24-,25-,26+,28-,30+,31+,32+/m0/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 4.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Rytmion Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of GTPgammaS-induced activation of GIRK1/4 (unknown origin) expressed in HEK293 cells assessed as decrease in channel current after 2 mins... |
J Nat Prod 79: 1990-2004 (2016)
Article DOI: 10.1021/acs.jnatprod.6b00260
BindingDB Entry DOI: 10.7270/Q2CC12NJ |
More data for this
Ligand-Target Pair | |
G protein-activated inward rectifier potassium channel 4
(Homo sapiens (Human)) | BDBM50202481
(CHEMBL3901192)Show SMILES [H][C@@]12C[C@](C)(OC(C)=O)[C@]1([H])[C@@]1([H])[C@@]3(C)OC[C@@]1([C@H](OC(C)=O)[C@@]1([H])[C@@H](OC(=O)c4cccnc4)[C@@H](C)C[C@]1(OC(C)=O)[C@H]3OC(C)=O)C(=O)[C@@H]2OC(=O)C(C)CC |r| Show InChI InChI=1S/C39H49NO14/c1-10-18(2)33(46)52-29-25-15-36(8,53-22(6)43)26(25)30-37(9)35(50-21(5)42)39(54-23(7)44)14-19(3)28(51-34(47)24-12-11-13-40-16-24)27(39)32(49-20(4)41)38(30,17-48-37)31(29)45/h11-13,16,18-19,25-30,32,35H,10,14-15,17H2,1-9H3/t18?,19-,25+,26-,27+,28-,29+,30-,32+,35-,36-,37+,38-,39+/m0/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 4.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Rytmion Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of GTPgammaS-induced activation of GIRK1/4 (unknown origin) expressed in HEK293 cells assessed as decrease in channel current after 2 mins... |
J Nat Prod 79: 1990-2004 (2016)
Article DOI: 10.1021/acs.jnatprod.6b00260
BindingDB Entry DOI: 10.7270/Q2CC12NJ |
More data for this
Ligand-Target Pair | |
G protein-activated inward rectifier potassium channel 4
(Homo sapiens (Human)) | BDBM50202478
(CHEMBL3899370)Show SMILES [H][C@]12[C@@H](OC(=O)CC)[C@@H](C)C[C@]1(OC(C)=O)[C@@H](OC(C)=O)[C@]1(C)OC[C@@]3([C@@H]2OC(C)=O)C(=O)C=C[C@@H]([C@@]13[H])C(C)(C)OC(C)=O |r,c:35| Show InChI InChI=1S/C31H42O12/c1-10-22(37)41-24-15(2)13-31(43-19(6)35)23(24)26(39-16(3)32)30-14-38-29(9,27(31)40-17(4)33)25(30)20(11-12-21(30)36)28(7,8)42-18(5)34/h11-12,15,20,23-27H,10,13-14H2,1-9H3/t15-,20-,23+,24-,25-,26+,27-,29+,30+,31+/m0/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 6.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Rytmion Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of GTPgammaS-induced activation of GIRK1/4 (unknown origin) expressed in HEK293 cells assessed as decrease in channel current after 2 mins... |
J Nat Prod 79: 1990-2004 (2016)
Article DOI: 10.1021/acs.jnatprod.6b00260
BindingDB Entry DOI: 10.7270/Q2CC12NJ |
More data for this
Ligand-Target Pair | |
G protein-activated inward rectifier potassium channel 4
(Homo sapiens (Human)) | BDBM50202480
(CHEMBL3961215)Show SMILES [H][C@@]12C[C@](C)(OC(C)=O)[C@]1([H])[C@@]1([H])[C@@]3(C)OC[C@@]1([C@H](OC(C)=O)[C@@]1([H])[C@@H](OC(=O)C(C)C)[C@@H](C)C[C@]1(OC(C)=O)[C@H]3OC(C)=O)C(=O)[C@@H]2OC(C)=O |r| Show InChI InChI=1S/C34H46O14/c1-14(2)29(41)46-24-15(3)11-34(48-20(8)39)23(24)28(44-17(5)36)33-13-42-32(10,30(34)45-18(6)37)26(33)22-21(12-31(22,9)47-19(7)38)25(27(33)40)43-16(4)35/h14-15,21-26,28,30H,11-13H2,1-10H3/t15-,21+,22-,23+,24-,25+,26-,28+,30-,31-,32+,33-,34+/m0/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 9.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Rytmion Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of GTPgammaS-induced activation of GIRK1/4 (unknown origin) expressed in HEK293 cells assessed as decrease in channel current after 2 mins... |
J Nat Prod 79: 1990-2004 (2016)
Article DOI: 10.1021/acs.jnatprod.6b00260
BindingDB Entry DOI: 10.7270/Q2CC12NJ |
More data for this
Ligand-Target Pair | |
G protein-activated inward rectifier potassium channel 4
(Homo sapiens (Human)) | BDBM50468098
(CHEMBL4283713)Show SMILES [H][C@@]12C[C@@H](C)[C@@]34C=C(C)[C@H](OC(=O)C(\C)=C/C)[C@@]3(O)[C@H](O)C(C)=C[C@]([H])(C4=O)[C@]1([H])C2(C)C |r,c:23,t:6| Show InChI InChI=1S/C25H34O5/c1-8-12(2)22(28)30-21-14(4)11-24-15(5)10-17-18(23(17,6)7)16(20(24)27)9-13(3)19(26)25(21,24)29/h8-9,11,15-19,21,26,29H,10H2,1-7H3/b12-8-/t15-,16+,17-,18+,19-,21+,24-,25+/m1/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.22E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Rytmion Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of GIRK-1/4 channel (unknown origin) expressed in HEK293 cells by automated patch clamp method |
J Nat Prod 81: 2483-2492 (2018)
Article DOI: 10.1021/acs.jnatprod.8b00500
BindingDB Entry DOI: 10.7270/Q2765J1T |
More data for this
Ligand-Target Pair | |
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