Found 426 hits with Last Name = 'pagès' and Initial = 'l' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50353707
(CHEMBL1830791)Show SMILES CC1(C)CCc2c(Nc3c(Cl)cncc3Cl)nc3oc4c(NCc5cccnc5)ncnc4c3c2C1 Show InChI InChI=1S/C26H23Cl2N7O/c1-26(2)6-5-15-16(8-26)19-21-22(24(33-13-32-21)31-10-14-4-3-7-29-9-14)36-25(19)35-23(15)34-20-17(27)11-30-12-18(20)28/h3-4,7,9,11-13H,5-6,8,10H2,1-2H3,(H,30,34,35)(H,31,32,33) | PDB
UniProtKB/SwissProt
antibodypedia
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AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.0200 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of human PDE4B1 assessed as inhibition of [3H]cAMP hydrolysis to [3H]AMP after 15 mins by scintillation proximity assay |
Eur J Med Chem 46: 4946-56 (2011)
Article DOI: 10.1016/j.ejmech.2011.07.054
BindingDB Entry DOI: 10.7270/Q2VM4CPM |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
(Homo sapiens (Human)) | BDBM50353703
(CHEMBL1830646)Show SMILES CC(C)Nc1nc2oc3c(NCCCN4CCCC4=O)ncnc3c2c2CC(C)(C)CCc12 Show InChI InChI=1S/C25H34N6O2/c1-15(2)29-22-16-8-9-25(3,4)13-17(16)19-20-21(33-24(19)30-22)23(28-14-27-20)26-10-6-12-31-11-5-7-18(31)32/h14-15H,5-13H2,1-4H3,(H,29,30)(H,26,27,28) | PDB
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.100 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of human PDE4D3 assessed as inhibition of [3H]cAMP hydrolysis to [3H]AMP after 15 mins by scintillation proximity assay |
Eur J Med Chem 46: 4946-56 (2011)
Article DOI: 10.1016/j.ejmech.2011.07.054
BindingDB Entry DOI: 10.7270/Q2VM4CPM |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50353703
(CHEMBL1830646)Show SMILES CC(C)Nc1nc2oc3c(NCCCN4CCCC4=O)ncnc3c2c2CC(C)(C)CCc12 Show InChI InChI=1S/C25H34N6O2/c1-15(2)29-22-16-8-9-25(3,4)13-17(16)19-20-21(33-24(19)30-22)23(28-14-27-20)26-10-6-12-31-11-5-7-18(31)32/h14-15H,5-13H2,1-4H3,(H,29,30)(H,26,27,28) | PDB
UniProtKB/SwissProt
antibodypedia
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| CHEMBL
PC cid
PC sid
UniChem
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| Article
PubMed
| n/a | n/a | 0.100 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of human PDE4B1 assessed as inhibition of [3H]cAMP hydrolysis to [3H]AMP after 15 mins by scintillation proximity assay |
Eur J Med Chem 46: 4946-56 (2011)
Article DOI: 10.1016/j.ejmech.2011.07.054
BindingDB Entry DOI: 10.7270/Q2VM4CPM |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50353700
(CHEMBL1830643)Show SMILES CC(C)Nc1nc2oc3c(NCCN4CCOCC4)ncnc3c2c2CC(C)(C)CCc12 Show InChI InChI=1S/C24H34N6O2/c1-15(2)28-21-16-5-6-24(3,4)13-17(16)18-19-20(32-23(18)29-21)22(27-14-26-19)25-7-8-30-9-11-31-12-10-30/h14-15H,5-13H2,1-4H3,(H,28,29)(H,25,26,27) | PDB
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| CHEMBL
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UniChem
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| n/a | n/a | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of human PDE4B1 assessed as inhibition of [3H]cAMP hydrolysis to [3H]AMP after 15 mins by scintillation proximity assay |
Eur J Med Chem 46: 4946-56 (2011)
Article DOI: 10.1016/j.ejmech.2011.07.054
BindingDB Entry DOI: 10.7270/Q2VM4CPM |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50353706
(CHEMBL1828652)Show SMILES CC(C)Nc1nc2oc3c(NCc4cccnc4)ncnc3c2c2CC(C)(C)CCc12 Show InChI InChI=1S/C24H28N6O/c1-14(2)29-21-16-7-8-24(3,4)10-17(16)18-19-20(31-23(18)30-21)22(28-13-27-19)26-12-15-6-5-9-25-11-15/h5-6,9,11,13-14H,7-8,10,12H2,1-4H3,(H,29,30)(H,26,27,28) | PDB
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| CHEMBL
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| n/a | n/a | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of human PDE4B1 assessed as inhibition of [3H]cAMP hydrolysis to [3H]AMP after 15 mins by scintillation proximity assay |
Eur J Med Chem 46: 4946-56 (2011)
Article DOI: 10.1016/j.ejmech.2011.07.054
BindingDB Entry DOI: 10.7270/Q2VM4CPM |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
(Homo sapiens (Human)) | BDBM14774
(3-(cyclopropylmethoxy)-N-(3,5-dichloropyridin-4-yl...)Show SMILES FC(F)Oc1ccc(cc1OCC1CC1)C(=O)Nc1c(Cl)cncc1Cl Show InChI InChI=1S/C17H14Cl2F2N2O3/c18-11-6-22-7-12(19)15(11)23-16(24)10-3-4-13(26-17(20)21)14(5-10)25-8-9-1-2-9/h3-7,9,17H,1-2,8H2,(H,22,23,24) | PDB
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Article
PubMed
| n/a | n/a | 0.270 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of human PDE4D3 assessed as inhibition of [3H]cAMP hydrolysis to [3H]AMP after 15 mins by scintillation proximity assay |
Eur J Med Chem 46: 4946-56 (2011)
Article DOI: 10.1016/j.ejmech.2011.07.054
BindingDB Entry DOI: 10.7270/Q2VM4CPM |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A
(Homo sapiens (Human)) | BDBM50353703
(CHEMBL1830646)Show SMILES CC(C)Nc1nc2oc3c(NCCCN4CCCC4=O)ncnc3c2c2CC(C)(C)CCc12 Show InChI InChI=1S/C25H34N6O2/c1-15(2)29-22-16-8-9-25(3,4)13-17(16)19-20-21(33-24(19)30-22)23(28-14-27-20)26-10-6-12-31-11-5-7-18(31)32/h14-15H,5-13H2,1-4H3,(H,29,30)(H,26,27,28) | PDB
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| CHEMBL
PC cid
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UniChem
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PubMed
| n/a | n/a | 0.300 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of human PDE4A4 assessed as inhibition of [3H]cAMP hydrolysis to [3H]AMP after 15 mins by scintillation proximity assay |
Eur J Med Chem 46: 4946-56 (2011)
Article DOI: 10.1016/j.ejmech.2011.07.054
BindingDB Entry DOI: 10.7270/Q2VM4CPM |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
(Homo sapiens (Human)) | BDBM50353700
(CHEMBL1830643)Show SMILES CC(C)Nc1nc2oc3c(NCCN4CCOCC4)ncnc3c2c2CC(C)(C)CCc12 Show InChI InChI=1S/C24H34N6O2/c1-15(2)28-21-16-5-6-24(3,4)13-17(16)18-19-20(32-23(18)29-21)22(27-14-26-19)25-7-8-30-9-11-31-12-10-30/h14-15H,5-13H2,1-4H3,(H,28,29)(H,25,26,27) | PDB
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| n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of human PDE4D3 assessed as inhibition of [3H]cAMP hydrolysis to [3H]AMP after 15 mins by scintillation proximity assay |
Eur J Med Chem 46: 4946-56 (2011)
Article DOI: 10.1016/j.ejmech.2011.07.054
BindingDB Entry DOI: 10.7270/Q2VM4CPM |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A
(Homo sapiens (Human)) | BDBM50353700
(CHEMBL1830643)Show SMILES CC(C)Nc1nc2oc3c(NCCN4CCOCC4)ncnc3c2c2CC(C)(C)CCc12 Show InChI InChI=1S/C24H34N6O2/c1-15(2)28-21-16-5-6-24(3,4)13-17(16)18-19-20(32-23(18)29-21)22(27-14-26-19)25-7-8-30-9-11-31-12-10-30/h14-15H,5-13H2,1-4H3,(H,28,29)(H,25,26,27) | PDB
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| n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of human PDE4A4 assessed as inhibition of [3H]cAMP hydrolysis to [3H]AMP after 15 mins by scintillation proximity assay |
Eur J Med Chem 46: 4946-56 (2011)
Article DOI: 10.1016/j.ejmech.2011.07.054
BindingDB Entry DOI: 10.7270/Q2VM4CPM |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
(Homo sapiens (Human)) | BDBM50353706
(CHEMBL1828652)Show SMILES CC(C)Nc1nc2oc3c(NCc4cccnc4)ncnc3c2c2CC(C)(C)CCc12 Show InChI InChI=1S/C24H28N6O/c1-14(2)29-21-16-7-8-24(3,4)10-17(16)18-19-20(31-23(18)30-21)22(28-13-27-19)26-12-15-6-5-9-25-11-15/h5-6,9,11,13-14H,7-8,10,12H2,1-4H3,(H,29,30)(H,26,27,28) | PDB
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| n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of human PDE4D3 assessed as inhibition of [3H]cAMP hydrolysis to [3H]AMP after 15 mins by scintillation proximity assay |
Eur J Med Chem 46: 4946-56 (2011)
Article DOI: 10.1016/j.ejmech.2011.07.054
BindingDB Entry DOI: 10.7270/Q2VM4CPM |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A
(Homo sapiens (Human)) | BDBM14774
(3-(cyclopropylmethoxy)-N-(3,5-dichloropyridin-4-yl...)Show SMILES FC(F)Oc1ccc(cc1OCC1CC1)C(=O)Nc1c(Cl)cncc1Cl Show InChI InChI=1S/C17H14Cl2F2N2O3/c18-11-6-22-7-12(19)15(11)23-16(24)10-3-4-13(26-17(20)21)14(5-10)25-8-9-1-2-9/h3-7,9,17H,1-2,8H2,(H,22,23,24) | PDB
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| DrugBank
Article
PubMed
| n/a | n/a | 0.590 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of human PDE4A4 assessed as inhibition of [3H]cAMP hydrolysis to [3H]AMP after 15 mins by scintillation proximity assay |
Eur J Med Chem 46: 4946-56 (2011)
Article DOI: 10.1016/j.ejmech.2011.07.054
BindingDB Entry DOI: 10.7270/Q2VM4CPM |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM14774
(3-(cyclopropylmethoxy)-N-(3,5-dichloropyridin-4-yl...)Show SMILES FC(F)Oc1ccc(cc1OCC1CC1)C(=O)Nc1c(Cl)cncc1Cl Show InChI InChI=1S/C17H14Cl2F2N2O3/c18-11-6-22-7-12(19)15(11)23-16(24)10-3-4-13(26-17(20)21)14(5-10)25-8-9-1-2-9/h3-7,9,17H,1-2,8H2,(H,22,23,24) | PDB
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Article
PubMed
| n/a | n/a | 0.690 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of human PDE4B1 assessed as inhibition of [3H]cAMP hydrolysis to [3H]AMP after 15 mins by scintillation proximity assay |
Eur J Med Chem 46: 4946-56 (2011)
Article DOI: 10.1016/j.ejmech.2011.07.054
BindingDB Entry DOI: 10.7270/Q2VM4CPM |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50353695
(CHEMBL1830638)Show SMILES CC1(C)CCc2c(C1)c1c(nc2N2CCOCC2)oc2c(ncnc12)N(CCO)CCN1CCOCC1 Show InChI InChI=1S/C27H38N6O4/c1-27(2)4-3-19-20(17-27)21-22-23(37-26(21)30-24(19)33-10-15-36-16-11-33)25(29-18-28-22)32(7-12-34)6-5-31-8-13-35-14-9-31/h18,34H,3-17H2,1-2H3 | PDB
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.800 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of human PDE4B1 assessed as inhibition of [3H]cAMP hydrolysis to [3H]AMP after 15 mins by scintillation proximity assay |
Eur J Med Chem 46: 4946-56 (2011)
Article DOI: 10.1016/j.ejmech.2011.07.054
BindingDB Entry DOI: 10.7270/Q2VM4CPM |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A
(Homo sapiens (Human)) | BDBM50353706
(CHEMBL1828652)Show SMILES CC(C)Nc1nc2oc3c(NCc4cccnc4)ncnc3c2c2CC(C)(C)CCc12 Show InChI InChI=1S/C24H28N6O/c1-14(2)29-21-16-7-8-24(3,4)10-17(16)18-19-20(31-23(18)30-21)22(28-13-27-19)26-12-15-6-5-9-25-11-15/h5-6,9,11,13-14H,7-8,10,12H2,1-4H3,(H,29,30)(H,26,27,28) | PDB
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PubMed
| n/a | n/a | 0.900 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of human PDE4A4 assessed as inhibition of [3H]cAMP hydrolysis to [3H]AMP after 15 mins by scintillation proximity assay |
Eur J Med Chem 46: 4946-56 (2011)
Article DOI: 10.1016/j.ejmech.2011.07.054
BindingDB Entry DOI: 10.7270/Q2VM4CPM |
More data for this
Ligand-Target Pair | |
Cysteinyl leukotriene receptor 1
(GUINEA PIG) | BDBM50296089
(2-(2-(5-(3-(2-(6,7-difluoroquinolin-2-yl)vinyl)ben...)Show SMILES OC(=O)c1ccccc1OCCN1CCc2c(C1)c1ccccc1n2Cc1cccc(\C=C\c2ccc3cc(F)c(F)cc3n2)c1 Show InChI InChI=1S/C38H31F2N3O3/c39-32-21-27-13-15-28(41-34(27)22-33(32)40)14-12-25-6-5-7-26(20-25)23-43-35-10-3-1-8-29(35)31-24-42(17-16-36(31)43)18-19-46-37-11-4-2-9-30(37)38(44)45/h1-15,20-22H,16-19,23-24H2,(H,44,45)/b14-12+ | PDB
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| n/a | n/a | 0.910 | n/a | n/a | n/a | n/a | n/a | n/a |
Universitat de Barcelona
Curated by ChEMBL
| Assay Description
Displacement of [3H]LTD4 from CYSLT1 receptor in guinea pig lung membrane |
Bioorg Med Chem Lett 19: 4299-302 (2009)
Article DOI: 10.1016/j.bmcl.2009.05.094
BindingDB Entry DOI: 10.7270/Q2CN73Z1 |
More data for this
Ligand-Target Pair | |
Cysteinyl leukotriene receptor 1
(GUINEA PIG) | BDBM50296106
(3-(5-(3-(2-(6,7-difluoroquinolin-2-yl)vinyl)benzyl...)Show SMILES OC(=O)CCN1CCc2c(C1)c1ccccc1n2Cc1cccc(\C=C\c2ccc3cc(F)c(F)cc3n2)c1 Show InChI InChI=1S/C32H27F2N3O2/c33-27-17-23-9-11-24(35-29(23)18-28(27)34)10-8-21-4-3-5-22(16-21)19-37-30-7-2-1-6-25(30)26-20-36(14-12-31(26)37)15-13-32(38)39/h1-11,16-18H,12-15,19-20H2,(H,38,39)/b10-8+ | PDB
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| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Universitat de Barcelona
Curated by ChEMBL
| Assay Description
Displacement of [3H]LTD4 from CYSLT1 receptor in guinea pig lung membrane |
Bioorg Med Chem Lett 19: 4299-302 (2009)
Article DOI: 10.1016/j.bmcl.2009.05.094
BindingDB Entry DOI: 10.7270/Q2CN73Z1 |
More data for this
Ligand-Target Pair | |
Cysteinyl leukotriene receptor 1
(GUINEA PIG) | BDBM50296095
(2-(2-(1H-tetrazol-5-yl)ethyl)-9-(3-(2-(7-chloroqui...)Show SMILES Clc1ccc2ccc(C=Cc3cccc(Cn4c5CN(CCc6nnn[nH]6)CCc5c5ccccc45)c3)nc2c1 |w:9.9| Show InChI InChI=1S/C32H28ClN7/c33-25-11-9-24-10-13-26(34-29(24)19-25)12-8-22-4-3-5-23(18-22)20-40-30-7-2-1-6-27(30)28-14-16-39(21-31(28)40)17-15-32-35-37-38-36-32/h1-13,18-19H,14-17,20-21H2,(H,35,36,37,38) | PDB
UniProtKB/SwissProt
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| CHEMBL
PC cid
PC sid
UniChem
| Article
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| n/a | n/a | 1.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Universitat de Barcelona
Curated by ChEMBL
| Assay Description
Displacement of [3H]LTD4 from CYSLT1 receptor in guinea pig lung membrane |
Bioorg Med Chem Lett 19: 4299-302 (2009)
Article DOI: 10.1016/j.bmcl.2009.05.094
BindingDB Entry DOI: 10.7270/Q2CN73Z1 |
More data for this
Ligand-Target Pair | |
Cysteinyl leukotriene receptor 1
(GUINEA PIG) | BDBM50296115
(3-(5-(3-(2-(6,7-difluoroquinolin-2-yl)vinyl)benzyl...)Show SMILES OC(=O)CCN1CCc2c(C1)c1c(F)cccc1n2Cc1cccc(\C=C\c2ccc3cc(F)c(F)cc3n2)c1 Show InChI InChI=1S/C32H26F3N3O2/c33-25-5-2-6-30-32(25)24-19-37(14-12-31(39)40)13-11-29(24)38(30)18-21-4-1-3-20(15-21)7-9-23-10-8-22-16-26(34)27(35)17-28(22)36-23/h1-10,15-17H,11-14,18-19H2,(H,39,40)/b9-7+ | PDB
UniProtKB/SwissProt
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| CHEMBL
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UniChem
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| Article
PubMed
| n/a | n/a | 1.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Universitat de Barcelona
Curated by ChEMBL
| Assay Description
Displacement of [3H]LTD4 from CYSLT1 receptor in guinea pig lung membrane |
Bioorg Med Chem Lett 19: 4299-302 (2009)
Article DOI: 10.1016/j.bmcl.2009.05.094
BindingDB Entry DOI: 10.7270/Q2CN73Z1 |
More data for this
Ligand-Target Pair | |
Cysteinyl leukotriene receptor 1
(GUINEA PIG) | BDBM50296092
(3-(5-(3-((7-chloroquinolin-2-yl)ethynyl)benzyl)-3,...)Show SMILES OC(=O)CCN1CCc2c(C1)c1ccccc1n2Cc1cccc(c1)C#Cc1ccc2ccc(Cl)cc2n1 Show InChI InChI=1S/C32H26ClN3O2/c33-25-11-9-24-10-13-26(34-29(24)19-25)12-8-22-4-3-5-23(18-22)20-36-30-7-2-1-6-27(30)28-21-35(16-14-31(28)36)17-15-32(37)38/h1-7,9-11,13,18-19H,14-17,20-21H2,(H,37,38) | PDB
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| CHEMBL
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UniChem
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| Article
PubMed
| n/a | n/a | 1.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Universitat de Barcelona
Curated by ChEMBL
| Assay Description
Displacement of [3H]LTD4 from CYSLT1 receptor in guinea pig lung membrane |
Bioorg Med Chem Lett 19: 4299-302 (2009)
Article DOI: 10.1016/j.bmcl.2009.05.094
BindingDB Entry DOI: 10.7270/Q2CN73Z1 |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
(Homo sapiens (Human)) | BDBM50353705
(CHEMBL1830790)Show SMILES CCNc1nc2oc3c(NCc4cccnc4)ncnc3c2c2CC(C)(C)CCc12 Show InChI InChI=1S/C23H26N6O/c1-4-25-20-15-7-8-23(2,3)10-16(15)17-18-19(30-22(17)29-20)21(28-13-27-18)26-12-14-6-5-9-24-11-14/h5-6,9,11,13H,4,7-8,10,12H2,1-3H3,(H,25,29)(H,26,27,28) | PDB
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UniChem
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PubMed
| n/a | n/a | 1.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of human PDE4D3 assessed as inhibition of [3H]cAMP hydrolysis to [3H]AMP after 15 mins by scintillation proximity assay |
Eur J Med Chem 46: 4946-56 (2011)
Article DOI: 10.1016/j.ejmech.2011.07.054
BindingDB Entry DOI: 10.7270/Q2VM4CPM |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
(Homo sapiens (Human)) | BDBM50353701
(CHEMBL1830644)Show SMILES CCNc1nc2oc3c(NCCCN4CCCC4=O)ncnc3c2c2CC(C)(C)CCc12 Show InChI InChI=1S/C24H32N6O2/c1-4-25-21-15-8-9-24(2,3)13-16(15)18-19-20(32-23(18)29-21)22(28-14-27-19)26-10-6-12-30-11-5-7-17(30)31/h14H,4-13H2,1-3H3,(H,25,29)(H,26,27,28) | PDB
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UniChem
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PubMed
| n/a | n/a | 1.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of human PDE4D3 assessed as inhibition of [3H]cAMP hydrolysis to [3H]AMP after 15 mins by scintillation proximity assay |
Eur J Med Chem 46: 4946-56 (2011)
Article DOI: 10.1016/j.ejmech.2011.07.054
BindingDB Entry DOI: 10.7270/Q2VM4CPM |
More data for this
Ligand-Target Pair | |
Cysteinyl leukotriene receptor 1
(GUINEA PIG) | BDBM50296105
(3-(5-(3-(2-(7-chloro-6-fluoroquinolin-2-yl)vinyl)b...)Show SMILES OC(=O)CCN1CCc2c(C1)c1ccccc1n2Cc1cccc(\C=C\c2ccc3cc(F)c(Cl)cc3n2)c1 Show InChI InChI=1S/C32H27ClFN3O2/c33-27-18-29-23(17-28(27)34)9-11-24(35-29)10-8-21-4-3-5-22(16-21)19-37-30-7-2-1-6-25(30)26-20-36(14-12-31(26)37)15-13-32(38)39/h1-11,16-18H,12-15,19-20H2,(H,38,39)/b10-8+ | PDB
UniProtKB/SwissProt
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| CHEMBL
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UniChem
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| Article
PubMed
| n/a | n/a | 1.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Universitat de Barcelona
Curated by ChEMBL
| Assay Description
Displacement of [3H]LTD4 from CYSLT1 receptor in guinea pig lung membrane |
Bioorg Med Chem Lett 19: 4299-302 (2009)
Article DOI: 10.1016/j.bmcl.2009.05.094
BindingDB Entry DOI: 10.7270/Q2CN73Z1 |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50353701
(CHEMBL1830644)Show SMILES CCNc1nc2oc3c(NCCCN4CCCC4=O)ncnc3c2c2CC(C)(C)CCc12 Show InChI InChI=1S/C24H32N6O2/c1-4-25-21-15-8-9-24(2,3)13-16(15)18-19-20(32-23(18)29-21)22(28-14-27-19)26-10-6-12-30-11-5-7-17(30)31/h14H,4-13H2,1-3H3,(H,25,29)(H,26,27,28) | PDB
UniProtKB/SwissProt
antibodypedia
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of human PDE4B1 assessed as inhibition of [3H]cAMP hydrolysis to [3H]AMP after 15 mins by scintillation proximity assay |
Eur J Med Chem 46: 4946-56 (2011)
Article DOI: 10.1016/j.ejmech.2011.07.054
BindingDB Entry DOI: 10.7270/Q2VM4CPM |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
(Homo sapiens (Human)) | BDBM50328090
(2-[(2,2-Dimethyl-5-morpholin-4-yl-1,2,3,4-tetrahyd...)Show SMILES CC1(C)CCc2c(C1)c1c(nc2N2CCOCC2)sc2c(ncnc12)N(CCO)CCN1CCOCC1 Show InChI InChI=1S/C27H38N6O3S/c1-27(2)4-3-19-20(17-27)21-22-23(37-26(21)30-24(19)33-10-15-36-16-11-33)25(29-18-28-22)32(7-12-34)6-5-31-8-13-35-14-9-31/h18,34H,3-17H2,1-2H3 | PDB
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| CHEMBL
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PC sid
UniChem
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| Article
PubMed
| n/a | n/a | 1.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of PDE4D3 expressed in yeast |
J Med Chem 53: 6912-22 (2010)
Article DOI: 10.1021/jm100524j
BindingDB Entry DOI: 10.7270/Q2J966K2 |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50353698
(CHEMBL1830641)Show SMILES CCNc1nc2oc3c(NCCN4CCOCC4)ncnc3c2c2CC(C)(C)CCc12 Show InChI InChI=1S/C23H32N6O2/c1-4-24-20-15-5-6-23(2,3)13-16(15)17-18-19(31-22(17)28-20)21(27-14-26-18)25-7-8-29-9-11-30-12-10-29/h14H,4-13H2,1-3H3,(H,24,28)(H,25,26,27) | PDB
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| CHEMBL
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PC sid
UniChem
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PubMed
| n/a | n/a | 2.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of human PDE4B1 assessed as inhibition of [3H]cAMP hydrolysis to [3H]AMP after 15 mins by scintillation proximity assay |
Eur J Med Chem 46: 4946-56 (2011)
Article DOI: 10.1016/j.ejmech.2011.07.054
BindingDB Entry DOI: 10.7270/Q2VM4CPM |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
(Homo sapiens (Human)) | BDBM50353695
(CHEMBL1830638)Show SMILES CC1(C)CCc2c(C1)c1c(nc2N2CCOCC2)oc2c(ncnc12)N(CCO)CCN1CCOCC1 Show InChI InChI=1S/C27H38N6O4/c1-27(2)4-3-19-20(17-27)21-22-23(37-26(21)30-24(19)33-10-15-36-16-11-33)25(29-18-28-22)32(7-12-34)6-5-31-8-13-35-14-9-31/h18,34H,3-17H2,1-2H3 | PDB
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antibodypedia
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| CHEMBL
PC cid
PC sid
UniChem
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| Article
PubMed
| n/a | n/a | 2.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of human PDE4D3 assessed as inhibition of [3H]cAMP hydrolysis to [3H]AMP after 15 mins by scintillation proximity assay |
Eur J Med Chem 46: 4946-56 (2011)
Article DOI: 10.1016/j.ejmech.2011.07.054
BindingDB Entry DOI: 10.7270/Q2VM4CPM |
More data for this
Ligand-Target Pair | |
Cysteinyl leukotriene receptor 1
(GUINEA PIG) | BDBM50296114
(3-(5-(3-(2-(6,7-difluoroquinolin-2-yl)vinyl)benzyl...)Show SMILES OC(=O)CCN1CCc2c(C1)c1cc(F)ccc1n2Cc1cccc(\C=C\c2ccc3cc(F)c(F)cc3n2)c1 Show InChI InChI=1S/C32H26F3N3O2/c33-23-6-9-30-25(16-23)26-19-37(13-11-32(39)40)12-10-31(26)38(30)18-21-3-1-2-20(14-21)4-7-24-8-5-22-15-27(34)28(35)17-29(22)36-24/h1-9,14-17H,10-13,18-19H2,(H,39,40)/b7-4+ | PDB
UniProtKB/SwissProt
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| CHEMBL
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UniChem
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| Article
PubMed
| n/a | n/a | 2.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Universitat de Barcelona
Curated by ChEMBL
| Assay Description
Displacement of [3H]LTD4 from CYSLT1 receptor in guinea pig lung membrane |
Bioorg Med Chem Lett 19: 4299-302 (2009)
Article DOI: 10.1016/j.bmcl.2009.05.094
BindingDB Entry DOI: 10.7270/Q2CN73Z1 |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
(Homo sapiens (Human)) | BDBM50353698
(CHEMBL1830641)Show SMILES CCNc1nc2oc3c(NCCN4CCOCC4)ncnc3c2c2CC(C)(C)CCc12 Show InChI InChI=1S/C23H32N6O2/c1-4-24-20-15-5-6-23(2,3)13-16(15)17-18-19(31-22(17)28-20)21(27-14-26-18)25-7-8-29-9-11-30-12-10-29/h14H,4-13H2,1-3H3,(H,24,28)(H,25,26,27) | PDB
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antibodypedia
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| CHEMBL
PC cid
PC sid
UniChem
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PubMed
| n/a | n/a | 2.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of human PDE4D3 assessed as inhibition of [3H]cAMP hydrolysis to [3H]AMP after 15 mins by scintillation proximity assay |
Eur J Med Chem 46: 4946-56 (2011)
Article DOI: 10.1016/j.ejmech.2011.07.054
BindingDB Entry DOI: 10.7270/Q2VM4CPM |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50328090
(2-[(2,2-Dimethyl-5-morpholin-4-yl-1,2,3,4-tetrahyd...)Show SMILES CC1(C)CCc2c(C1)c1c(nc2N2CCOCC2)sc2c(ncnc12)N(CCO)CCN1CCOCC1 Show InChI InChI=1S/C27H38N6O3S/c1-27(2)4-3-19-20(17-27)21-22-23(37-26(21)30-24(19)33-10-15-36-16-11-33)25(29-18-28-22)32(7-12-34)6-5-31-8-13-35-14-9-31/h18,34H,3-17H2,1-2H3 | PDB
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| CHEMBL
PC cid
PC sid
UniChem
Similars
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PubMed
| n/a | n/a | 2.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of PDE4B1 expressed in yeast |
J Med Chem 53: 6912-22 (2010)
Article DOI: 10.1021/jm100524j
BindingDB Entry DOI: 10.7270/Q2J966K2 |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50328091
(2,2-Dimethyl-5-morpholin-4-yl-N-(2-morpholin-4-yle...)Show SMILES CC1(C)CCc2c(C1)c1c(nc2N2CCOCC2)sc2c(NCCN3CCOCC3)ncnc12 Show InChI InChI=1S/C25H34N6O2S/c1-25(2)4-3-17-18(15-25)19-20-21(34-24(19)29-23(17)31-9-13-33-14-10-31)22(28-16-27-20)26-5-6-30-7-11-32-12-8-30/h16H,3-15H2,1-2H3,(H,26,27,28) | PDB
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| CHEMBL
PC cid
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UniChem
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PubMed
| n/a | n/a | 2.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of PDE4B1 expressed in yeast |
J Med Chem 53: 6912-22 (2010)
Article DOI: 10.1021/jm100524j
BindingDB Entry DOI: 10.7270/Q2J966K2 |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50328092
(5-(3-Furyl)-2,2-dimethyl-N-(2-morpholin-4-ylethyl)...)Show SMILES CC1(C)CCc2c(C1)c1c(nc2-c2ccoc2)sc2c(NCCN3CCOCC3)ncnc12 Show InChI InChI=1S/C25H29N5O2S/c1-25(2)5-3-17-18(13-25)19-21-22(33-24(19)29-20(17)16-4-10-32-14-16)23(28-15-27-21)26-6-7-30-8-11-31-12-9-30/h4,10,14-15H,3,5-9,11-13H2,1-2H3,(H,26,27,28) | PDB
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PC cid
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UniChem
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PubMed
| n/a | n/a | 2.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of PDE4B1 expressed in yeast |
J Med Chem 53: 6912-22 (2010)
Article DOI: 10.1021/jm100524j
BindingDB Entry DOI: 10.7270/Q2J966K2 |
More data for this
Ligand-Target Pair | |
Cysteinyl leukotriene receptor 1
(GUINEA PIG) | BDBM50296088
(4-((5-(3-(2-(6,7-difluoroquinolin-2-yl)vinyl)benzy...)Show SMILES OC(=O)c1ccc(CN2CCc3c(C2)c2ccccc2n3Cc2cccc(\C=C\c3ccc4cc(F)c(F)cc4n3)c2)cc1 Show InChI InChI=1S/C37H29F2N3O2/c38-32-19-28-13-15-29(40-34(28)20-33(32)39)14-10-24-4-3-5-26(18-24)22-42-35-7-2-1-6-30(35)31-23-41(17-16-36(31)42)21-25-8-11-27(12-9-25)37(43)44/h1-15,18-20H,16-17,21-23H2,(H,43,44)/b14-10+ | PDB
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UniChem
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| Article
PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Universitat de Barcelona
Curated by ChEMBL
| Assay Description
Displacement of [3H]LTD4 from CYSLT1 receptor in guinea pig lung membrane |
Bioorg Med Chem Lett 19: 4299-302 (2009)
Article DOI: 10.1016/j.bmcl.2009.05.094
BindingDB Entry DOI: 10.7270/Q2CN73Z1 |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
(Homo sapiens (Human)) | BDBM50328092
(5-(3-Furyl)-2,2-dimethyl-N-(2-morpholin-4-ylethyl)...)Show SMILES CC1(C)CCc2c(C1)c1c(nc2-c2ccoc2)sc2c(NCCN3CCOCC3)ncnc12 Show InChI InChI=1S/C25H29N5O2S/c1-25(2)5-3-17-18(13-25)19-21-22(33-24(19)29-20(17)16-4-10-32-14-16)23(28-15-27-21)26-6-7-30-8-11-31-12-9-30/h4,10,14-15H,3,5-9,11-13H2,1-2H3,(H,26,27,28) | PDB
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PC cid
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UniChem
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PubMed
| n/a | n/a | 3.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of PDE4D3 expressed in yeast |
J Med Chem 53: 6912-22 (2010)
Article DOI: 10.1021/jm100524j
BindingDB Entry DOI: 10.7270/Q2J966K2 |
More data for this
Ligand-Target Pair | |
Cysteinyl leukotriene receptor 1
(GUINEA PIG) | BDBM50296085
(2-(1-((5-(3-(2-(7-chloroquinolin-2-yl)vinyl)benzyl...)Show SMILES OC(=O)CC1(CN2CCc3c(C2)c2ccccc2n3Cc2cccc(\C=C\c3ccc4ccc(Cl)cc4n3)c2)CC1 Show InChI InChI=1S/C35H32ClN3O2/c36-27-11-9-26-10-13-28(37-31(26)19-27)12-8-24-4-3-5-25(18-24)21-39-32-7-2-1-6-29(32)30-22-38(17-14-33(30)39)23-35(15-16-35)20-34(40)41/h1-13,18-19H,14-17,20-23H2,(H,40,41)/b12-8+ | PDB
UniProtKB/SwissProt
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| CHEMBL
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PC sid
UniChem
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| Article
PubMed
| n/a | n/a | 3.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Universitat de Barcelona
Curated by ChEMBL
| Assay Description
Displacement of [3H]LTD4 from CYSLT1 receptor in guinea pig lung membrane |
Bioorg Med Chem Lett 19: 4299-302 (2009)
Article DOI: 10.1016/j.bmcl.2009.05.094
BindingDB Entry DOI: 10.7270/Q2CN73Z1 |
More data for this
Ligand-Target Pair | |
Cysteinyl leukotriene receptor 1
(GUINEA PIG) | BDBM50296103
(3-(5-(3-(2-(7-fluoroquinolin-2-yl)vinyl)benzyl)-3,...)Show SMILES OC(=O)CCN1CCc2c(C1)c1ccccc1n2Cc1cccc(\C=C\c2ccc3ccc(F)cc3n2)c1 Show InChI InChI=1S/C32H28FN3O2/c33-25-11-9-24-10-13-26(34-29(24)19-25)12-8-22-4-3-5-23(18-22)20-36-30-7-2-1-6-27(30)28-21-35(16-14-31(28)36)17-15-32(37)38/h1-13,18-19H,14-17,20-21H2,(H,37,38)/b12-8+ | PDB
UniProtKB/SwissProt
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AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Universitat de Barcelona
Curated by ChEMBL
| Assay Description
Displacement of [3H]LTD4 from CYSLT1 receptor in guinea pig lung membrane |
Bioorg Med Chem Lett 19: 4299-302 (2009)
Article DOI: 10.1016/j.bmcl.2009.05.094
BindingDB Entry DOI: 10.7270/Q2CN73Z1 |
More data for this
Ligand-Target Pair | |
Cysteinyl leukotriene receptor 1
(GUINEA PIG) | BDBM50296102
(4-(1-(3-(2-(7-chloroquinolin-2-yl)vinyl)benzyl)-2-...)Show SMILES Cc1c(CCCC(O)=O)c2ccccc2n1Cc1cccc(\C=C\c2ccc3ccc(Cl)cc3n2)c1 Show InChI InChI=1S/C31H27ClN2O2/c1-21-27(9-5-11-31(35)36)28-8-2-3-10-30(28)34(21)20-23-7-4-6-22(18-23)12-16-26-17-14-24-13-15-25(32)19-29(24)33-26/h2-4,6-8,10,12-19H,5,9,11,20H2,1H3,(H,35,36)/b16-12+ | PDB
UniProtKB/SwissProt
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| CHEMBL
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PC sid
UniChem
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| Article
PubMed
| n/a | n/a | 3.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Universitat de Barcelona
Curated by ChEMBL
| Assay Description
Displacement of [3H]LTD4 from CYSLT1 receptor in guinea pig lung membrane |
Bioorg Med Chem Lett 19: 4299-302 (2009)
Article DOI: 10.1016/j.bmcl.2009.05.094
BindingDB Entry DOI: 10.7270/Q2CN73Z1 |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50328093
(2,2-Dimethyl-5-morpholin-4-yl-N-(pyridin-3-ylmethy...)Show SMILES CC1(C)CCc2c(C1)c1c(nc2N2CCOCC2)sc2c(NCc3cccnc3)ncnc12 Show InChI InChI=1S/C25H28N6OS/c1-25(2)6-5-17-18(12-25)19-20-21(33-24(19)30-23(17)31-8-10-32-11-9-31)22(29-15-28-20)27-14-16-4-3-7-26-13-16/h3-4,7,13,15H,5-6,8-12,14H2,1-2H3,(H,27,28,29) | PDB
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antibodypedia
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AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of PDE4B1 expressed in yeast |
J Med Chem 53: 6912-22 (2010)
Article DOI: 10.1021/jm100524j
BindingDB Entry DOI: 10.7270/Q2J966K2 |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50328094
(5-(2-Furyl)-2,2-dimethyl-N-(2-morpholin-4-ylethyl)...)Show SMILES CC1(C)CCc2c(C1)c1c(nc2-c2ccco2)sc2c(NCCN3CCOCC3)ncnc12 Show InChI InChI=1S/C25H29N5O2S/c1-25(2)6-5-16-17(14-25)19-21-22(33-24(19)29-20(16)18-4-3-11-32-18)23(28-15-27-21)26-7-8-30-9-12-31-13-10-30/h3-4,11,15H,5-10,12-14H2,1-2H3,(H,26,27,28) | PDB
UniProtKB/SwissProt
antibodypedia
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| CHEMBL
PC cid
PC sid
UniChem
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| Article
PubMed
| n/a | n/a | 3.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of PDE4B1 expressed in yeast |
J Med Chem 53: 6912-22 (2010)
Article DOI: 10.1021/jm100524j
BindingDB Entry DOI: 10.7270/Q2J966K2 |
More data for this
Ligand-Target Pair | |
Cysteinyl leukotriene receptor 1
(GUINEA PIG) | BDBM50296087
(4-(5-(3-((E)-2-(7-chloroquinolin-2-yl)vinyl)benzyl...)Show SMILES OC(=O)\C=C\CN1CCc2c(C1)c1ccccc1n2Cc1cccc(\C=C\c2ccc3ccc(Cl)cc3n2)c1 Show InChI InChI=1S/C33H28ClN3O2/c34-26-13-11-25-12-15-27(35-30(25)20-26)14-10-23-5-3-6-24(19-23)21-37-31-8-2-1-7-28(31)29-22-36(18-16-32(29)37)17-4-9-33(38)39/h1-15,19-20H,16-18,21-22H2,(H,38,39)/b9-4+,14-10+ | PDB
UniProtKB/SwissProt
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PC sid
UniChem
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| Article
PubMed
| n/a | n/a | 4.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Universitat de Barcelona
Curated by ChEMBL
| Assay Description
Displacement of [3H]LTD4 from CYSLT1 receptor in guinea pig lung membrane |
Bioorg Med Chem Lett 19: 4299-302 (2009)
Article DOI: 10.1016/j.bmcl.2009.05.094
BindingDB Entry DOI: 10.7270/Q2CN73Z1 |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
(Homo sapiens (Human)) | BDBM50328095
(CHEMBL1258806 | N5,2,2-Trimethyl-N8-(2-morpholin-4...)Show SMILES CNc1nc2sc3c(NCCN4CCOCC4)ncnc3c2c2CC(C)(C)CCc12 Show InChI InChI=1S/C22H30N6OS/c1-22(2)5-4-14-15(12-22)16-17-18(30-21(16)27-19(14)23-3)20(26-13-25-17)24-6-7-28-8-10-29-11-9-28/h13H,4-12H2,1-3H3,(H,23,27)(H,24,25,26) | PDB
KEGG
UniProtKB/SwissProt
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DrugBank
antibodypedia
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of PDE4D3 expressed in yeast |
J Med Chem 53: 6912-22 (2010)
Article DOI: 10.1021/jm100524j
BindingDB Entry DOI: 10.7270/Q2J966K2 |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50353705
(CHEMBL1830790)Show SMILES CCNc1nc2oc3c(NCc4cccnc4)ncnc3c2c2CC(C)(C)CCc12 Show InChI InChI=1S/C23H26N6O/c1-4-25-20-15-7-8-23(2,3)10-16(15)17-18-19(30-22(17)29-20)21(28-13-27-18)26-12-14-6-5-9-24-11-14/h5-6,9,11,13H,4,7-8,10,12H2,1-3H3,(H,25,29)(H,26,27,28) | PDB
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antibodypedia
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of human PDE4B1 assessed as inhibition of [3H]cAMP hydrolysis to [3H]AMP after 15 mins by scintillation proximity assay |
Eur J Med Chem 46: 4946-56 (2011)
Article DOI: 10.1016/j.ejmech.2011.07.054
BindingDB Entry DOI: 10.7270/Q2VM4CPM |
More data for this
Ligand-Target Pair | |
Cysteinyl leukotriene receptor 1
(GUINEA PIG) | BDBM50296101
(4-(1-(3-(2-(7-chloroquinolin-2-yl)vinyl)benzyl)-1H...)Show SMILES OC(=O)CCCc1cn(Cc2cccc(\C=C\c3ccc4ccc(Cl)cc4n3)c2)c2ccccc12 Show InChI InChI=1S/C30H25ClN2O2/c31-25-14-12-23-13-16-26(32-28(23)18-25)15-11-21-5-3-6-22(17-21)19-33-20-24(7-4-10-30(34)35)27-8-1-2-9-29(27)33/h1-3,5-6,8-9,11-18,20H,4,7,10,19H2,(H,34,35)/b15-11+ | PDB
UniProtKB/SwissProt
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AffyNet
| CHEMBL
PC cid
PC sid
UniChem
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| Article
PubMed
| n/a | n/a | 4.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Universitat de Barcelona
Curated by ChEMBL
| Assay Description
Displacement of [3H]LTD4 from CYSLT1 receptor in guinea pig lung membrane |
Bioorg Med Chem Lett 19: 4299-302 (2009)
Article DOI: 10.1016/j.bmcl.2009.05.094
BindingDB Entry DOI: 10.7270/Q2CN73Z1 |
More data for this
Ligand-Target Pair | |
Cysteinyl leukotriene receptor 1
(GUINEA PIG) | BDBM50296113
(3-(5-(3-(2-(6,7-difluoroquinolin-2-yl)vinyl)benzyl...)Show SMILES OC(=O)CCN1CCc2c(C1)c1ccc(F)cc1n2Cc1cccc(\C=C\c2ccc3cc(F)c(F)cc3n2)c1 Show InChI InChI=1S/C32H26F3N3O2/c33-23-6-9-25-26-19-37(13-11-32(39)40)12-10-30(26)38(31(25)16-23)18-21-3-1-2-20(14-21)4-7-24-8-5-22-15-27(34)28(35)17-29(22)36-24/h1-9,14-17H,10-13,18-19H2,(H,39,40)/b7-4+ | PDB
UniProtKB/SwissProt
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Universitat de Barcelona
Curated by ChEMBL
| Assay Description
Displacement of [3H]LTD4 from CYSLT1 receptor in guinea pig lung membrane |
Bioorg Med Chem Lett 19: 4299-302 (2009)
Article DOI: 10.1016/j.bmcl.2009.05.094
BindingDB Entry DOI: 10.7270/Q2CN73Z1 |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A
(Homo sapiens (Human)) | BDBM50328093
(2,2-Dimethyl-5-morpholin-4-yl-N-(pyridin-3-ylmethy...)Show SMILES CC1(C)CCc2c(C1)c1c(nc2N2CCOCC2)sc2c(NCc3cccnc3)ncnc12 Show InChI InChI=1S/C25H28N6OS/c1-25(2)6-5-17-18(12-25)19-20-21(33-24(19)30-23(17)31-8-10-32-11-9-31)22(29-15-28-20)27-14-16-4-3-7-26-13-16/h3-4,7,13,15H,5-6,8-12,14H2,1-2H3,(H,27,28,29) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of PDE4A4 expressed in yeast |
J Med Chem 53: 6912-22 (2010)
Article DOI: 10.1021/jm100524j
BindingDB Entry DOI: 10.7270/Q2J966K2 |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50328096
(2,2-Dimethyl-5-morpholin-4-yl-N-(2-morpholin-4-yle...)Show SMILES CC1(C)Cc2c(CO1)c(nc1sc3c(ncnc3c21)N(CCN1CCOCC1)Cc1cccnc1)N1CCOCC1 Show InChI InChI=1S/C30H37N7O3S/c1-30(2)16-22-23(19-40-30)27(36-10-14-39-15-11-36)34-29-24(22)25-26(41-29)28(33-20-32-25)37(18-21-4-3-5-31-17-21)7-6-35-8-12-38-13-9-35/h3-5,17,20H,6-16,18-19H2,1-2H3 | PDB
UniProtKB/SwissProt
antibodypedia
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| CHEMBL
PC cid
PC sid
UniChem
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| Article
PubMed
| n/a | n/a | 4.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of PDE4B1 expressed in yeast |
J Med Chem 53: 6912-22 (2010)
Article DOI: 10.1021/jm100524j
BindingDB Entry DOI: 10.7270/Q2J966K2 |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
(Homo sapiens (Human)) | BDBM50328091
(2,2-Dimethyl-5-morpholin-4-yl-N-(2-morpholin-4-yle...)Show SMILES CC1(C)CCc2c(C1)c1c(nc2N2CCOCC2)sc2c(NCCN3CCOCC3)ncnc12 Show InChI InChI=1S/C25H34N6O2S/c1-25(2)4-3-17-18(15-25)19-20-21(34-24(19)29-23(17)31-9-13-33-14-10-31)22(28-16-27-20)26-5-6-30-7-11-32-12-8-30/h16H,3-15H2,1-2H3,(H,26,27,28) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of PDE4D3 expressed in yeast |
J Med Chem 53: 6912-22 (2010)
Article DOI: 10.1021/jm100524j
BindingDB Entry DOI: 10.7270/Q2J966K2 |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A
(Homo sapiens (Human)) | BDBM50353695
(CHEMBL1830638)Show SMILES CC1(C)CCc2c(C1)c1c(nc2N2CCOCC2)oc2c(ncnc12)N(CCO)CCN1CCOCC1 Show InChI InChI=1S/C27H38N6O4/c1-27(2)4-3-19-20(17-27)21-22-23(37-26(21)30-24(19)33-10-15-36-16-11-33)25(29-18-28-22)32(7-12-34)6-5-31-8-13-35-14-9-31/h18,34H,3-17H2,1-2H3 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of human PDE4A4 assessed as inhibition of [3H]cAMP hydrolysis to [3H]AMP after 15 mins by scintillation proximity assay |
Eur J Med Chem 46: 4946-56 (2011)
Article DOI: 10.1016/j.ejmech.2011.07.054
BindingDB Entry DOI: 10.7270/Q2VM4CPM |
More data for this
Ligand-Target Pair | |
Cysteinyl leukotriene receptor 1
(GUINEA PIG) | BDBM50296099
(3-(9-(3-(2-(7-chloroquinolin-2-yl)vinyl)benzyl)-9H...)Show SMILES OC(=O)CCc1ccc2n(Cc3cccc(\C=C\c4ccc5ccc(Cl)cc5n4)c3)c3ccccc3c2c1 Show InChI InChI=1S/C33H25ClN2O2/c34-26-13-11-25-12-15-27(35-30(25)20-26)14-8-22-4-3-5-24(18-22)21-36-31-7-2-1-6-28(31)29-19-23(9-16-32(29)36)10-17-33(37)38/h1-9,11-16,18-20H,10,17,21H2,(H,37,38)/b14-8+ | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 4.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Universitat de Barcelona
Curated by ChEMBL
| Assay Description
Displacement of [3H]LTD4 from CYSLT1 receptor in guinea pig lung membrane |
Bioorg Med Chem Lett 19: 4299-302 (2009)
Article DOI: 10.1016/j.bmcl.2009.05.094
BindingDB Entry DOI: 10.7270/Q2CN73Z1 |
More data for this
Ligand-Target Pair | |
Cysteinyl leukotriene receptor 1
(GUINEA PIG) | BDBM50296100
(2-(9-(3-(2-(7-chloroquinolin-2-yl)vinyl)benzyl)-2,...)Show SMILES OC(=O)CC1CCc2c(C1)c1ccccc1n2Cc1cccc(\C=C\c2ccc3ccc(Cl)cc3n2)c1 Show InChI InChI=1S/C32H27ClN2O2/c33-25-12-10-24-11-14-26(34-29(24)19-25)13-8-21-4-3-5-23(16-21)20-35-30-7-2-1-6-27(30)28-17-22(18-32(36)37)9-15-31(28)35/h1-8,10-14,16,19,22H,9,15,17-18,20H2,(H,36,37)/b13-8+ | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Universitat de Barcelona
Curated by ChEMBL
| Assay Description
Displacement of [3H]LTD4 from CYSLT1 receptor in guinea pig lung membrane |
Bioorg Med Chem Lett 19: 4299-302 (2009)
Article DOI: 10.1016/j.bmcl.2009.05.094
BindingDB Entry DOI: 10.7270/Q2CN73Z1 |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A
(Homo sapiens (Human)) | BDBM50328096
(2,2-Dimethyl-5-morpholin-4-yl-N-(2-morpholin-4-yle...)Show SMILES CC1(C)Cc2c(CO1)c(nc1sc3c(ncnc3c21)N(CCN1CCOCC1)Cc1cccnc1)N1CCOCC1 Show InChI InChI=1S/C30H37N7O3S/c1-30(2)16-22-23(19-40-30)27(36-10-14-39-15-11-36)34-29-24(22)25-26(41-29)28(33-20-32-25)37(18-21-4-3-5-31-17-21)7-6-35-8-12-38-13-9-35/h3-5,17,20H,6-16,18-19H2,1-2H3 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of PDE4A4 expressed in yeast |
J Med Chem 53: 6912-22 (2010)
Article DOI: 10.1021/jm100524j
BindingDB Entry DOI: 10.7270/Q2J966K2 |
More data for this
Ligand-Target Pair | |
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