Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Neuronal acetylcholine receptor subunit alpha-4/beta-2 (Rattus norvegicus (Rat)) | BDBM50066789 (3-((S)-1-Azetidin-2-ylmethoxy)-5-iodo-pyridine | A...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | 0.0500 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. Curated by ChEMBL | Assay Description Displacement of [3H]epibatidine from alpha4beta2 nAChR in rat brain membrane | J Med Chem 56: 593-624 (2013) Article DOI: 10.1021/jm3011433 BindingDB Entry DOI: 10.7270/Q23B61GZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neuronal acetylcholine receptor subunit alpha-4/beta-2 (Homo sapiens (Human)) | BDBM50166908 (5,8,14-triazatetracyclo[10.3.1.02,11.04,9]hexadeca...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars | PDB Article PubMed | 0.0600 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. Curated by ChEMBL | Assay Description Binding affinity to alpha4beta2 nAChR in rat cortex | J Med Chem 56: 593-624 (2013) Article DOI: 10.1021/jm3011433 BindingDB Entry DOI: 10.7270/Q23B61GZ | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Gamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2 (Homo sapiens (Human)) | BDBM144227 (US8952008, 4) | GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Similars | Article PubMed | 0.180 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. Curated by ChEMBL | Assay Description Displacement of [3H]-flumazenil from human GABAA alpha1beta3gamma2 receptor expressed in HEK293 cell membranes measured after 2 hrs by liquid scintil... | J Med Chem 62: 5773-5796 (2019) Article DOI: 10.1021/acs.jmedchem.9b00322 BindingDB Entry DOI: 10.7270/Q2HQ437D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Gamma-aminobutyric acid receptor subunit alpha-5 (Homo sapiens (Human)) | BDBM50067424 ((S)-9-Methoxy-7-oxo-3b,4,5,6-tetrahydro-7H-2,6a,11...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | 0.450 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. Curated by ChEMBL | Assay Description Positive allosteric modulation of GABAA alpha5 (unknown origin) | J Med Chem 56: 593-624 (2013) Article DOI: 10.1021/jm3011433 BindingDB Entry DOI: 10.7270/Q23B61GZ | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Gamma-aminobutyric acid receptor subunit alpha-3 (Homo sapiens (Human)) | BDBM50142570 (9-(4-Methyl-thiazol-2-yl)-11-pyridin-4-yl-6,7-dihy...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. Curated by ChEMBL | Assay Description Positive allosteric modulation of GABAA alpha3 (unknown origin) | J Med Chem 56: 593-624 (2013) Article DOI: 10.1021/jm3011433 BindingDB Entry DOI: 10.7270/Q23B61GZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Gamma-aminobutyric acid receptor subunit alpha-2 (Homo sapiens (Human)) | BDBM430025 (4-(4′-Ethanesulfonyl-6-fluoro-2′-metho...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | <0.600 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
PFIZER LIMITED US Patent | Assay Description The affinity of the test compounds was determined by radioligand competition binding assay, using the known compound [3H]Ro-15-1788 (Flumazenil) (Per... | US Patent US10538523 (2020) BindingDB Entry DOI: 10.7270/Q2RB771W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Gamma-aminobutyric acid receptor subunit alpha-2 (Homo sapiens (Human)) | BDBM50142570 (9-(4-Methyl-thiazol-2-yl)-11-pyridin-4-yl-6,7-dihy...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 0.600 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. Curated by ChEMBL | Assay Description Positive allosteric modulation of GABAA alpha2 (unknown origin) | J Med Chem 56: 593-624 (2013) Article DOI: 10.1021/jm3011433 BindingDB Entry DOI: 10.7270/Q23B61GZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Gamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2 (Homo sapiens (Human)) | BDBM50512947 (CHEMBL4545044) | GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 0.640 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. Curated by ChEMBL | Assay Description Displacement of [3H]-flumazenil from human GABAA alpha1beta3gamma2 receptor expressed in HEK293 cell membranes measured after 2 hrs by liquid scintil... | J Med Chem 62: 5773-5796 (2019) Article DOI: 10.1021/acs.jmedchem.9b00322 BindingDB Entry DOI: 10.7270/Q2HQ437D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Gamma-aminobutyric acid receptor subunit alpha-3 (Homo sapiens (Human)) | BDBM50179998 (7-tert-butyl-3-(2,5-difluorophenyl)-6-((2-methyl-2...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | 0.700 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. Curated by ChEMBL | Assay Description Positive allosteric modulation of GABAA alpha3 (unknown origin) | J Med Chem 56: 593-624 (2013) Article DOI: 10.1021/jm3011433 BindingDB Entry DOI: 10.7270/Q23B61GZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Gamma-aminobutyric acid receptor subunit alpha-2 (Homo sapiens (Human)) | BDBM50179998 (7-tert-butyl-3-(2,5-difluorophenyl)-6-((2-methyl-2...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | 0.700 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. Curated by ChEMBL | Assay Description Positive allosteric modulation of GABAA alpha2 (unknown origin) | J Med Chem 56: 593-624 (2013) Article DOI: 10.1021/jm3011433 BindingDB Entry DOI: 10.7270/Q23B61GZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Gamma-aminobutyric acid receptor subunit alpha-1 (Homo sapiens (Human)) | BDBM50156083 (3-tert-Butyl-7-(5-methyl-isoxazol-3-yl)-2-(2-methy...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 0.800 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. Curated by ChEMBL | Assay Description Positive allosteric modulation of GABAA alpha1 (unknown origin) | J Med Chem 56: 593-624 (2013) Article DOI: 10.1021/jm3011433 BindingDB Entry DOI: 10.7270/Q23B61GZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Gamma-aminobutyric acid receptor subunit alpha-2 (Homo sapiens (Human)) | BDBM50156083 (3-tert-Butyl-7-(5-methyl-isoxazol-3-yl)-2-(2-methy...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 0.800 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. Curated by ChEMBL | Assay Description Positive allosteric modulation of GABAA alpha2 (unknown origin) | J Med Chem 56: 593-624 (2013) Article DOI: 10.1021/jm3011433 BindingDB Entry DOI: 10.7270/Q23B61GZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Gamma-aminobutyric acid receptor subunit alpha-3 (Homo sapiens (Human)) | BDBM50156083 (3-tert-Butyl-7-(5-methyl-isoxazol-3-yl)-2-(2-methy...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 0.800 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. Curated by ChEMBL | Assay Description Positive allosteric modulation of GABAA alpha3 (unknown origin) | J Med Chem 56: 593-624 (2013) Article DOI: 10.1021/jm3011433 BindingDB Entry DOI: 10.7270/Q23B61GZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Gamma-aminobutyric acid receptor subunit alpha-3/beta-3/gamma-2 (Homo sapiens (Human)) | BDBM144227 (US8952008, 4) | PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Similars | Article PubMed | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. Curated by ChEMBL | Assay Description Displacement of [3H]-flumazenil from human GABAA alpha3beta3gamma2 receptor expressed in HEK293 cell membranes measured after 2 hrs by liquid scintil... | J Med Chem 62: 5773-5796 (2019) Article DOI: 10.1021/acs.jmedchem.9b00322 BindingDB Entry DOI: 10.7270/Q2HQ437D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Gamma-aminobutyric acid receptor subunit alpha-1 (Homo sapiens (Human)) | BDBM50142570 (9-(4-Methyl-thiazol-2-yl)-11-pyridin-4-yl-6,7-dihy...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 1.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. Curated by ChEMBL | Assay Description Positive allosteric modulation of GABAA alpha1 (unknown origin) | J Med Chem 56: 593-624 (2013) Article DOI: 10.1021/jm3011433 BindingDB Entry DOI: 10.7270/Q23B61GZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Gamma-aminobutyric acid receptor subunit alpha-5 (Homo sapiens (Human)) | BDBM50156083 (3-tert-Butyl-7-(5-methyl-isoxazol-3-yl)-2-(2-methy...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 1.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. Curated by ChEMBL | Assay Description Positive allosteric modulation of GABAA alpha5 (unknown origin) | J Med Chem 56: 593-624 (2013) Article DOI: 10.1021/jm3011433 BindingDB Entry DOI: 10.7270/Q23B61GZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Gamma-aminobutyric acid receptor subunit alpha-5 (Homo sapiens (Human)) | BDBM50179998 (7-tert-butyl-3-(2,5-difluorophenyl)-6-((2-methyl-2...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | 2.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. Curated by ChEMBL | Assay Description Positive allosteric modulation of GABAA alpha5 (unknown origin) | J Med Chem 56: 593-624 (2013) Article DOI: 10.1021/jm3011433 BindingDB Entry DOI: 10.7270/Q23B61GZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Gamma-aminobutyric acid receptor subunit alpha-2 (Homo sapiens (Human)) | BDBM144227 (US8952008, 4) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Similars | US Patent | <2.47 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Limited US Patent | Assay Description The affinity of the test compounds was determined by radioligand competition binding assay, using the known compound [3H]Ro-15-1788 (Flumazenil) (Per... | US Patent US8952008 (2015) BindingDB Entry DOI: 10.7270/Q2XD10DW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Gamma-aminobutyric acid receptor subunit alpha-3/beta-3/gamma-2 (Homo sapiens (Human)) | BDBM50512947 (CHEMBL4545044) | PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 2.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. Curated by ChEMBL | Assay Description Displacement of [3H]-flumazenil from human GABAA alpha3beta3gamma2 receptor expressed in HEK293 cell membranes measured after 2 hrs by liquid scintil... | J Med Chem 62: 5773-5796 (2019) Article DOI: 10.1021/acs.jmedchem.9b00322 BindingDB Entry DOI: 10.7270/Q2HQ437D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Gamma-aminobutyric acid receptor subunit alpha-2 (Homo sapiens (Human)) | BDBM144226 (US8952008, 3) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | 5.08 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Limited US Patent | Assay Description The affinity of the test compounds was determined by radioligand competition binding assay, using the known compound [3H]Ro-15-1788 (Flumazenil) (Per... | US Patent US8952008 (2015) BindingDB Entry DOI: 10.7270/Q2XD10DW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Gamma-aminobutyric acid receptor subunit alpha-2 (Homo sapiens (Human)) | BDBM144239 (US8952008, 32) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | 5.82 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Limited US Patent | Assay Description The affinity of the test compounds was determined by radioligand competition binding assay, using the known compound [3H]Ro-15-1788 (Flumazenil) (Per... | US Patent US8952008 (2015) BindingDB Entry DOI: 10.7270/Q2XD10DW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Gamma-aminobutyric acid receptor subunit alpha-2 (Homo sapiens (Human)) | BDBM352410 (5′-(7-Ethyl-7H-imidazo[4,5-c]pyridazin-4-yl)...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 6.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Limited US Patent | Assay Description The affinity of the test compounds was determined by radioligand competition binding assay, using the known compound [3H]Ro-15-1788 (Flumazenil) (Per... | US Patent US9802945 (2017) BindingDB Entry DOI: 10.7270/Q2NP26JT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Gamma-aminobutyric acid receptor subunit alpha-2 (Homo sapiens (Human)) | BDBM352391 (5-{2-Fluoro-5-[7-(propan-2-yl)-7H-imidazo[4,5-c]py...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 6.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Limited US Patent | Assay Description The affinity of the test compounds was determined by radioligand competition binding assay, using the known compound [3H]Ro-15-1788 (Flumazenil) (Per... | US Patent US9802945 (2017) BindingDB Entry DOI: 10.7270/Q2NP26JT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Gamma-aminobutyric acid receptor subunit alpha-2 (Homo sapiens (Human)) | BDBM352390 (5-[5-(7-Ethyl-7H-imidazo[4,5-c]pyridazin-4-yl)-2-f...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 6.60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Limited US Patent | Assay Description The affinity of the test compounds was determined by radioligand competition binding assay, using the known compound [3H]Ro-15-1788 (Flumazenil) (Per... | US Patent US9802945 (2017) BindingDB Entry DOI: 10.7270/Q2NP26JT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Gamma-aminobutyric acid receptor subunit alpha-2 (Homo sapiens (Human)) | BDBM352405 (US9802945, 16) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 6.70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Limited US Patent | Assay Description The affinity of the test compounds was determined by radioligand competition binding assay, using the known compound [3H]Ro-15-1788 (Flumazenil) (Per... | US Patent US9802945 (2017) BindingDB Entry DOI: 10.7270/Q2NP26JT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Gamma-aminobutyric acid receptor subunit alpha-2 (Homo sapiens (Human)) | BDBM352398 (US9802945, 9) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 6.80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Limited US Patent | Assay Description The affinity of the test compounds was determined by radioligand competition binding assay, using the known compound [3H]Ro-15-1788 (Flumazenil) (Per... | US Patent US9802945 (2017) BindingDB Entry DOI: 10.7270/Q2NP26JT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Gamma-aminobutyric acid receptor subunit alpha-2 (Homo sapiens (Human)) | BDBM144252 (US8952008, 8) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | 7.45 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Limited US Patent | Assay Description The affinity of the test compounds was determined by radioligand competition binding assay, using the known compound [3H]Ro-15-1788 (Flumazenil) (Per... | US Patent US8952008 (2015) BindingDB Entry DOI: 10.7270/Q2XD10DW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Gamma-aminobutyric acid receptor subunit alpha-2 (Homo sapiens (Human)) | BDBM144256 (US8952008, 12) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | 7.48 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Limited US Patent | Assay Description The affinity of the test compounds was determined by radioligand competition binding assay, using the known compound [3H]Ro-15-1788 (Flumazenil) (Per... | US Patent US8952008 (2015) BindingDB Entry DOI: 10.7270/Q2XD10DW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Gamma-aminobutyric acid receptor subunit alpha-2 (Homo sapiens (Human)) | BDBM352403 (US9802945, 14) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 7.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Limited US Patent | Assay Description The affinity of the test compounds was determined by radioligand competition binding assay, using the known compound [3H]Ro-15-1788 (Flumazenil) (Per... | US Patent US9802945 (2017) BindingDB Entry DOI: 10.7270/Q2NP26JT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Gamma-aminobutyric acid receptor subunit alpha-2 (Homo sapiens (Human)) | BDBM144270 (US8952008, 38) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | 8.56 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Limited US Patent | Assay Description The affinity of the test compounds was determined by radioligand competition binding assay, using the known compound [3H]Ro-15-1788 (Flumazenil) (Per... | US Patent US8952008 (2015) BindingDB Entry DOI: 10.7270/Q2XD10DW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Gamma-aminobutyric acid receptor subunit alpha-2 (Homo sapiens (Human)) | BDBM144229 (US8952008, 6) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | 9.51 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Limited US Patent | Assay Description The affinity of the test compounds was determined by radioligand competition binding assay, using the known compound [3H]Ro-15-1788 (Flumazenil) (Per... | US Patent US8952008 (2015) BindingDB Entry DOI: 10.7270/Q2XD10DW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Gamma-aminobutyric acid receptor subunit alpha-2 (Homo sapiens (Human)) | BDBM144230 (US8952008, 7) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | 9.71 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Limited US Patent | Assay Description The affinity of the test compounds was determined by radioligand competition binding assay, using the known compound [3H]Ro-15-1788 (Flumazenil) (Per... | US Patent US8952008 (2015) BindingDB Entry DOI: 10.7270/Q2XD10DW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Gamma-aminobutyric acid receptor subunit alpha-2 (Homo sapiens (Human)) | BDBM352401 (2′-Fluoro-5′-[7-(propan-2-yl)-7H-imida...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 10.7 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Limited US Patent | Assay Description The affinity of the test compounds was determined by radioligand competition binding assay, using the known compound [3H]Ro-15-1788 (Flumazenil) (Per... | US Patent US9802945 (2017) BindingDB Entry DOI: 10.7270/Q2NP26JT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Gamma-aminobutyric acid receptor subunit alpha-2 (Homo sapiens (Human)) | BDBM144225 (US8952008, 2) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | 10.9 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Limited US Patent | Assay Description The affinity of the test compounds was determined by radioligand competition binding assay, using the known compound [3H]Ro-15-1788 (Flumazenil) (Per... | US Patent US8952008 (2015) BindingDB Entry DOI: 10.7270/Q2XD10DW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Gamma-aminobutyric acid receptor subunit alpha-2 (Homo sapiens (Human)) | BDBM144257 (US8952008, 13) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | 11.7 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Limited US Patent | Assay Description The affinity of the test compounds was determined by radioligand competition binding assay, using the known compound [3H]Ro-15-1788 (Flumazenil) (Per... | US Patent US8952008 (2015) BindingDB Entry DOI: 10.7270/Q2XD10DW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Gamma-aminobutyric acid receptor subunit alpha-2 (Homo sapiens (Human)) | BDBM430027 (5-[5-(1-Ethyl-1H-pyrazolo[3,4-c]pyridazin-4-yl)-2-...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 11.8 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
PFIZER LIMITED US Patent | Assay Description The affinity of the test compounds was determined by radioligand competition binding assay, using the known compound [3H]Ro-15-1788 (Flumazenil) (Per... | US Patent US10538523 (2020) BindingDB Entry DOI: 10.7270/Q2RB771W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Gamma-aminobutyric acid receptor subunit alpha-2 (Homo sapiens (Human)) | BDBM352392 (US9802945, 3) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 12.8 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Limited US Patent | Assay Description The affinity of the test compounds was determined by radioligand competition binding assay, using the known compound [3H]Ro-15-1788 (Flumazenil) (Per... | US Patent US9802945 (2017) BindingDB Entry DOI: 10.7270/Q2NP26JT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Gamma-aminobutyric acid receptor subunit alpha-2 (Homo sapiens (Human)) | BDBM144272 (US8952008, 40) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | 14 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Limited US Patent | Assay Description The affinity of the test compounds was determined by radioligand competition binding assay, using the known compound [3H]Ro-15-1788 (Flumazenil) (Per... | US Patent US8952008 (2015) BindingDB Entry DOI: 10.7270/Q2XD10DW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Gamma-aminobutyric acid receptor subunit alpha-2 (Homo sapiens (Human)) | BDBM144271 (US8952008, 39) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | 14.4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Limited US Patent | Assay Description The affinity of the test compounds was determined by radioligand competition binding assay, using the known compound [3H]Ro-15-1788 (Flumazenil) (Per... | US Patent US8952008 (2015) BindingDB Entry DOI: 10.7270/Q2XD10DW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Gamma-aminobutyric acid receptor subunit alpha-2 (Homo sapiens (Human)) | BDBM144240 (US8952008, 33) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | 16.4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Limited US Patent | Assay Description The affinity of the test compounds was determined by radioligand competition binding assay, using the known compound [3H]Ro-15-1788 (Flumazenil) (Per... | US Patent US8952008 (2015) BindingDB Entry DOI: 10.7270/Q2XD10DW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Gamma-aminobutyric acid receptor subunit alpha-2 (Homo sapiens (Human)) | BDBM430026 (4-(4′-Ethanesulfonyl-6-fluorobiphenyl-3-yl)-...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 17.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
PFIZER LIMITED US Patent | Assay Description The affinity of the test compounds was determined by radioligand competition binding assay, using the known compound [3H]Ro-15-1788 (Flumazenil) (Per... | US Patent US10538523 (2020) BindingDB Entry DOI: 10.7270/Q2RB771W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Gamma-aminobutyric acid receptor subunit alpha-2 (Homo sapiens (Human)) | BDBM144253 (US8952008, 9) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | 17.7 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Limited US Patent | Assay Description The affinity of the test compounds was determined by radioligand competition binding assay, using the known compound [3H]Ro-15-1788 (Flumazenil) (Per... | US Patent US8952008 (2015) BindingDB Entry DOI: 10.7270/Q2XD10DW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Gamma-aminobutyric acid receptor subunit alpha-5/beta-2/gamma-2 (Homo sapiens (Human)) | BDBM144227 (US8952008, 4) | PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Similars | Article PubMed | 18 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. Curated by ChEMBL | Assay Description Displacement of [3H]-flumazenil from human GABAA alpha5beta2gamma2 receptor expressed in HEK293 cell membranes measured after 2 hrs by liquid scintil... | J Med Chem 62: 5773-5796 (2019) Article DOI: 10.1021/acs.jmedchem.9b00322 BindingDB Entry DOI: 10.7270/Q2HQ437D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Gamma-aminobutyric acid receptor subunit alpha-2 (Homo sapiens (Human)) | BDBM144259 (US8952008, 15) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | 18.2 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Limited US Patent | Assay Description The affinity of the test compounds was determined by radioligand competition binding assay, using the known compound [3H]Ro-15-1788 (Flumazenil) (Per... | US Patent US8952008 (2015) BindingDB Entry DOI: 10.7270/Q2XD10DW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Gamma-aminobutyric acid receptor subunit alpha-2 (Homo sapiens (Human)) | BDBM144262 (US8952008, 20) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | 19 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Limited US Patent | Assay Description The affinity of the test compounds was determined by radioligand competition binding assay, using the known compound [3H]Ro-15-1788 (Flumazenil) (Per... | US Patent US8952008 (2015) BindingDB Entry DOI: 10.7270/Q2XD10DW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Gamma-aminobutyric acid receptor subunit alpha-2 (Homo sapiens (Human)) | BDBM144269 (US8952008, 37) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | 19.1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Limited US Patent | Assay Description The affinity of the test compounds was determined by radioligand competition binding assay, using the known compound [3H]Ro-15-1788 (Flumazenil) (Per... | US Patent US8952008 (2015) BindingDB Entry DOI: 10.7270/Q2XD10DW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Gamma-aminobutyric acid receptor subunit alpha-2 (Homo sapiens (Human)) | BDBM352407 (US9802945, 18) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 19.3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Limited US Patent | Assay Description The affinity of the test compounds was determined by radioligand competition binding assay, using the known compound [3H]Ro-15-1788 (Flumazenil) (Per... | US Patent US9802945 (2017) BindingDB Entry DOI: 10.7270/Q2NP26JT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Gamma-aminobutyric acid receptor subunit alpha-2 (Homo sapiens (Human)) | BDBM352404 (US9802945, 15) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 20.3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Limited US Patent | Assay Description The affinity of the test compounds was determined by radioligand competition binding assay, using the known compound [3H]Ro-15-1788 (Flumazenil) (Per... | US Patent US9802945 (2017) BindingDB Entry DOI: 10.7270/Q2NP26JT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Gamma-aminobutyric acid receptor subunit alpha-2 (Homo sapiens (Human)) | BDBM352400 (5′-(7-Cyclopropyl-7H-imidazo[4,5-c]pyridazin...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 20.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Limited US Patent | Assay Description The affinity of the test compounds was determined by radioligand competition binding assay, using the known compound [3H]Ro-15-1788 (Flumazenil) (Per... | US Patent US9802945 (2017) BindingDB Entry DOI: 10.7270/Q2NP26JT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Gamma-aminobutyric acid receptor subunit alpha-2 (Homo sapiens (Human)) | BDBM352394 (US9802945, 5) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 21.7 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Limited US Patent | Assay Description The affinity of the test compounds was determined by radioligand competition binding assay, using the known compound [3H]Ro-15-1788 (Flumazenil) (Per... | US Patent US9802945 (2017) BindingDB Entry DOI: 10.7270/Q2NP26JT | |||||||||||
More data for this Ligand-Target Pair |
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