Found 227 hits with Last Name = 'quan' and Initial = 'y' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Alanine racemase, biosynthetic
(Escherichia coli (strain K12)) | BDBM50022057
((1-Amino-2-chloro-ethyl)-phosphonic acid | CHEMBL3...)Show InChI InChI=1S/C2H7ClNO3P/c3-1-2(4)8(5,6)7/h2H,1,4H2,(H2,5,6,7) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| 8.20E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Apparent binding affinity of the compound was determined for Alanine racemase from Pseudomonas aeruginosa |
J Med Chem 29: 148-51 (1986)
BindingDB Entry DOI: 10.7270/Q20Z729S |
More data for this Ligand-Target Pair | |
Alanine racemase, biosynthetic
(Escherichia coli (strain K12)) | BDBM50022058
((1-Amino-2,2-dichloro-ethyl)-phosphonic acid | CHE...)Show InChI InChI=1S/C2H6Cl2NO3P/c3-1(4)2(5)9(6,7)8/h1-2H,5H2,(H2,6,7,8) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| 2.00E+6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Apparent binding affinity of the compound was determined for Alanine racemase from Pseudomonas aeruginosa |
J Med Chem 29: 148-51 (1986)
BindingDB Entry DOI: 10.7270/Q20Z729S |
More data for this Ligand-Target Pair | |
Alanine racemase, biosynthetic
(Escherichia coli (strain K12)) | BDBM50022057
((1-Amino-2-chloro-ethyl)-phosphonic acid | CHEMBL3...)Show InChI InChI=1S/C2H7ClNO3P/c3-1-2(4)8(5,6)7/h2H,1,4H2,(H2,5,6,7) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| 2.20E+6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Binding affinity of the compound was determined for Alanine racemase from Pseudomonas aeruginosa |
J Med Chem 29: 148-51 (1986)
BindingDB Entry DOI: 10.7270/Q20Z729S |
More data for this Ligand-Target Pair | |
Alanine racemase, biosynthetic
(Escherichia coli (strain K12)) | BDBM50022057
((1-Amino-2-chloro-ethyl)-phosphonic acid | CHEMBL3...)Show InChI InChI=1S/C2H7ClNO3P/c3-1-2(4)8(5,6)7/h2H,1,4H2,(H2,5,6,7) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| 2.20E+6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Binding affinity of the compound was determined for Alanine racemase from Pseudomonas aeruginosa |
J Med Chem 29: 148-51 (1986)
BindingDB Entry DOI: 10.7270/Q20Z729S |
More data for this Ligand-Target Pair | |
Alanine racemase, biosynthetic
(Escherichia coli (strain K12)) | BDBM50022057
((1-Amino-2-chloro-ethyl)-phosphonic acid | CHEMBL3...)Show InChI InChI=1S/C2H7ClNO3P/c3-1-2(4)8(5,6)7/h2H,1,4H2,(H2,5,6,7) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| 5.00E+6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Binding affinity against alanine racemase |
J Med Chem 29: 148-51 (1986)
BindingDB Entry DOI: 10.7270/Q20Z729S |
More data for this Ligand-Target Pair | |
Alanine racemase, biosynthetic
(Escherichia coli (strain K12)) | BDBM50019385
((1-Amino-allyl)-phosphonic acid | CHEMBL154711)Show InChI InChI=1S/C3H8NO3P/c1-2-3(4)8(5,6)7/h4H,2H2,1H3,(H2,5,6,7) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
| PubMed
| 8.50E+6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description The compound was tested for the inhibition of alanine racemase from Pseudomonas aeruginosa |
J Med Chem 29: 579-81 (1986)
BindingDB Entry DOI: 10.7270/Q26T0KMV |
More data for this Ligand-Target Pair | |
Alanine racemase, biosynthetic
(Escherichia coli (strain K12)) | BDBM50022058
((1-Amino-2,2-dichloro-ethyl)-phosphonic acid | CHE...)Show InChI InChI=1S/C2H6Cl2NO3P/c3-1(4)2(5)9(6,7)8/h1-2H,5H2,(H2,6,7,8) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| 1.50E+7 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Apparent binding affinity of the compound was determined for Alanine racemase from Pseudomonas aeruginosa |
J Med Chem 29: 148-51 (1986)
BindingDB Entry DOI: 10.7270/Q20Z729S |
More data for this Ligand-Target Pair | |
Alanine racemase, biosynthetic
(Escherichia coli (strain K12)) | BDBM50022058
((1-Amino-2,2-dichloro-ethyl)-phosphonic acid | CHE...)Show InChI InChI=1S/C2H6Cl2NO3P/c3-1(4)2(5)9(6,7)8/h1-2H,5H2,(H2,6,7,8) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| 1.50E+7 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Binding affinity of the compound was determined for Alanine racemase from Pseudomonas aeruginosa |
J Med Chem 29: 148-51 (1986)
BindingDB Entry DOI: 10.7270/Q20Z729S |
More data for this Ligand-Target Pair | |
Reverse transcriptase
(Human immunodeficiency virus 1) | BDBM2483
((4S)-6-chloro-4-(2-cyclopropylethynyl)-4-(trifluor...)Show SMILES FC(F)(F)[C@]1(OC(=O)Nc2ccc(Cl)cc12)C#CC1CC1 |r| Show InChI InChI=1S/C14H9ClF3NO2/c15-9-3-4-11-10(7-9)13(14(16,17)18,21-12(20)19-11)6-5-8-1-2-8/h3-4,7-8H,1-2H2,(H,19,20)/t13-/m0/s1 | PDB MMDB
UniProtKB/TrEMBL
B.MOAD GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 18 | n/a | n/a | n/a | n/a | n/a | n/a |
McGill University AIDS Centre
Curated by ChEMBL
| Assay Description Inhibition of Human immunodeficiency virus 1 subtype B reverse transcriptase DNA-dependent DNA polymerase activity by gel-based primer extension assa... |
Antimicrob Agents Chemother 53: 4667-72 (2009)
Article DOI: 10.1128/AAC.00800-09 BindingDB Entry DOI: 10.7270/Q2FN191R |
More data for this Ligand-Target Pair | |
Reverse transcriptase
(Human immunodeficiency virus 1) | BDBM50467334
(AIDS-105293 | Dapivirine | R-147681 | TMC-120)Show InChI InChI=1S/C20H19N5/c1-13-10-14(2)19(15(3)11-13)24-18-8-9-22-20(25-18)23-17-6-4-16(12-21)5-7-17/h4-11H,1-3H3,(H2,22,23,24,25) | PDB MMDB
UniProtKB/TrEMBL
B.MOAD GoogleScholar AffyNet
| Purchase
MCE PC cid PC sid PDB UniChem
| Article PubMed
| n/a | n/a | 19 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute-Jewish General Hospital
Curated by ChEMBL
| Assay Description Inhibition of RNA-dependent DNA polymerase activity of wild type HIV1 subtype B reverse transcriptase by filter-based filtration assay |
Antimicrob Agents Chemother 54: 2401-8 (2010)
Article DOI: 10.1128/AAC.01795-09 BindingDB Entry DOI: 10.7270/Q26D5WT1 |
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 6/G1/S-specific cyclin-D1
(Homo sapiens (Human)) | BDBM148264
(7-cyclopentyl-N,N-dimethyl-2-((5-(piperazin-1-yl)p...)Show SMILES CN(C)C(=O)c1cc2cnc(Nc3ccc(cn3)N3CCNCC3)nc2n1C1CCCC1 Show InChI InChI=1S/C23H30N8O/c1-29(2)22(32)19-13-16-14-26-23(28-21(16)31(19)17-5-3-4-6-17)27-20-8-7-18(15-25-20)30-11-9-24-10-12-30/h7-8,13-15,17,24H,3-6,9-12H2,1-2H3,(H,25,26,27,28) | PDB
KEGG
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar AffyNet
| Purchase
MCE PC cid PC sid PDB UniChem
Similars
| PDB Article PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of CDK6/cyclin D1 (unknown origin) |
Citation and Details
Article DOI: 10.1016/j.bmcl.2020.127725 BindingDB Entry DOI: 10.7270/Q2ZK5M9J |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1
(Homo sapiens (Human)) | BDBM50549567
(CHEMBL4793312)Show SMILES COc1ccccc1NC(=O)c1cc2cnc(Nc3ccc(cn3)N3CCNCC3)nc2n1C1CCCC1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 21 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of CDK4/cyclin D1 (unknown origin) |
Citation and Details
Article DOI: 10.1016/j.bmcl.2020.127725 BindingDB Entry DOI: 10.7270/Q2ZK5M9J |
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1
(Homo sapiens (Human)) | BDBM148264
(7-cyclopentyl-N,N-dimethyl-2-((5-(piperazin-1-yl)p...)Show SMILES CN(C)C(=O)c1cc2cnc(Nc3ccc(cn3)N3CCNCC3)nc2n1C1CCCC1 Show InChI InChI=1S/C23H30N8O/c1-29(2)22(32)19-13-16-14-26-23(28-21(16)31(19)17-5-3-4-6-17)27-20-8-7-18(15-25-20)30-11-9-24-10-12-30/h7-8,13-15,17,24H,3-6,9-12H2,1-2H3,(H,25,26,27,28) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| Purchase
MCE PC cid PC sid PDB UniChem
Similars
| Article PubMed
| n/a | n/a | 23 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of CDK4/cyclin D1 (unknown origin) |
Citation and Details
Article DOI: 10.1016/j.bmcl.2020.127725 BindingDB Entry DOI: 10.7270/Q2ZK5M9J |
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1
(Homo sapiens (Human)) | BDBM50549563
(CHEMBL4789393)Show SMILES Clc1ccccc1NC(=O)c1cc2cnc(Nc3ccc(cn3)N3CCNCC3)nc2n1C1CCCC1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 23 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of CDK4/cyclin D1 (unknown origin) |
Citation and Details
Article DOI: 10.1016/j.bmcl.2020.127725 BindingDB Entry DOI: 10.7270/Q2ZK5M9J |
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1
(Homo sapiens (Human)) | BDBM50549560
(CHEMBL4752087)Show SMILES Cc1ccccc1NC(=O)c1cc2cnc(Nc3ccc(cn3)N3CCNCC3)nc2n1C1CCCC1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 28 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of CDK4/cyclin D1 (unknown origin) |
Citation and Details
Article DOI: 10.1016/j.bmcl.2020.127725 BindingDB Entry DOI: 10.7270/Q2ZK5M9J |
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1
(Homo sapiens (Human)) | BDBM50549565
(CHEMBL4749923)Show SMILES COc1ccc(NC(=O)c2cc3cnc(Nc4ccc(cn4)N4CCNCC4)nc3n2C2CCCC2)c(OC)c1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 28 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of CDK4/cyclin D1 (unknown origin) |
Citation and Details
Article DOI: 10.1016/j.bmcl.2020.127725 BindingDB Entry DOI: 10.7270/Q2ZK5M9J |
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1
(Homo sapiens (Human)) | BDBM50549568
(CHEMBL4799064)Show SMILES O=C(Nc1ccccc1)c1cc2cnc(Nc3ccc(cn3)N3CCNCC3)nc2n1C1CCCC1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 29 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of CDK4/cyclin D1 (unknown origin) |
Citation and Details
Article DOI: 10.1016/j.bmcl.2020.127725 BindingDB Entry DOI: 10.7270/Q2ZK5M9J |
More data for this Ligand-Target Pair | |
Reverse transcriptase
(Human immunodeficiency virus 1) | BDBM2483
((4S)-6-chloro-4-(2-cyclopropylethynyl)-4-(trifluor...)Show SMILES FC(F)(F)[C@]1(OC(=O)Nc2ccc(Cl)cc12)C#CC1CC1 |r| Show InChI InChI=1S/C14H9ClF3NO2/c15-9-3-4-11-10(7-9)13(14(16,17)18,21-12(20)19-11)6-5-8-1-2-8/h3-4,7-8H,1-2H2,(H,19,20)/t13-/m0/s1 | PDB MMDB
UniProtKB/TrEMBL
B.MOAD GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute-Jewish General Hospital
Curated by ChEMBL
| Assay Description Inhibition of RNA-dependent DNA polymerase activity of wild type HIV1 subtype B reverse transcriptase by filter-based filtration assay |
Antimicrob Agents Chemother 54: 2401-8 (2010)
Article DOI: 10.1128/AAC.01795-09 BindingDB Entry DOI: 10.7270/Q26D5WT1 |
More data for this Ligand-Target Pair | |
Reverse transcriptase
(Human immunodeficiency virus 1) | BDBM2483
((4S)-6-chloro-4-(2-cyclopropylethynyl)-4-(trifluor...)Show SMILES FC(F)(F)[C@]1(OC(=O)Nc2ccc(Cl)cc12)C#CC1CC1 |r| Show InChI InChI=1S/C14H9ClF3NO2/c15-9-3-4-11-10(7-9)13(14(16,17)18,21-12(20)19-11)6-5-8-1-2-8/h3-4,7-8H,1-2H2,(H,19,20)/t13-/m0/s1 | PDB MMDB
UniProtKB/TrEMBL
B.MOAD GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 36 | n/a | n/a | n/a | n/a | n/a | n/a |
McGill University AIDS Centre
Curated by ChEMBL
| Assay Description Inhibition of DNA-dependent DNA polymerase activity of wild-type Human immunodeficiency virus 1 subtype B reverse transcriptase Y181C mutant by filte... |
Antimicrob Agents Chemother 53: 4667-72 (2009)
Article DOI: 10.1128/AAC.00800-09 BindingDB Entry DOI: 10.7270/Q2FN191R |
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1
(Homo sapiens (Human)) | BDBM50549562
(CHEMBL4796124)Show SMILES Fc1ccccc1NC(=O)c1cc2cnc(Nc3ccc(cn3)N3CCNCC3)nc2n1C1CCCC1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 45 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of CDK4/cyclin D1 (unknown origin) |
Citation and Details
Article DOI: 10.1016/j.bmcl.2020.127725 BindingDB Entry DOI: 10.7270/Q2ZK5M9J |
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 6/G1/S-specific cyclin-D1
(Homo sapiens (Human)) | BDBM50549567
(CHEMBL4793312)Show SMILES COc1ccccc1NC(=O)c1cc2cnc(Nc3ccc(cn3)N3CCNCC3)nc2n1C1CCCC1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 52 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of CDK6/cyclin D1 (unknown origin) |
Citation and Details
Article DOI: 10.1016/j.bmcl.2020.127725 BindingDB Entry DOI: 10.7270/Q2ZK5M9J |
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1
(Homo sapiens (Human)) | BDBM50549566
(CHEMBL4743047)Show SMILES COc1cccc(NC(=O)c2cc3cnc(Nc4ccc(cn4)N4CCNCC4)nc3n2C2CCCC2)c1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 53 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of CDK4/cyclin D1 (unknown origin) |
Citation and Details
Article DOI: 10.1016/j.bmcl.2020.127725 BindingDB Entry DOI: 10.7270/Q2ZK5M9J |
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 6/G1/S-specific cyclin-D1
(Homo sapiens (Human)) | BDBM50549563
(CHEMBL4789393)Show SMILES Clc1ccccc1NC(=O)c1cc2cnc(Nc3ccc(cn3)N3CCNCC3)nc2n1C1CCCC1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 53 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of CDK6/cyclin D1 (unknown origin) |
Citation and Details
Article DOI: 10.1016/j.bmcl.2020.127725 BindingDB Entry DOI: 10.7270/Q2ZK5M9J |
More data for this Ligand-Target Pair | |
Reverse transcriptase
(Human immunodeficiency virus 1) | BDBM2483
((4S)-6-chloro-4-(2-cyclopropylethynyl)-4-(trifluor...)Show SMILES FC(F)(F)[C@]1(OC(=O)Nc2ccc(Cl)cc12)C#CC1CC1 |r| Show InChI InChI=1S/C14H9ClF3NO2/c15-9-3-4-11-10(7-9)13(14(16,17)18,21-12(20)19-11)6-5-8-1-2-8/h3-4,7-8H,1-2H2,(H,19,20)/t13-/m0/s1 | PDB MMDB
UniProtKB/TrEMBL
B.MOAD GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 57 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute-Jewish General Hospital
Curated by ChEMBL
| Assay Description Inhibition of DNA-dependent DNA polymerase activity of wild type HIV1 subtype B reverse transcriptase by gel-based primer extension assay |
Antimicrob Agents Chemother 54: 2401-8 (2010)
Article DOI: 10.1128/AAC.01795-09 BindingDB Entry DOI: 10.7270/Q26D5WT1 |
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1
(Homo sapiens (Human)) | BDBM50549561
(CHEMBL4800120)Show SMILES FC(F)(F)c1ccccc1NC(=O)c1cc2cnc(Nc3ccc(cn3)N3CCNCC3)nc2n1C1CCCC1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of CDK4/cyclin D1 (unknown origin) |
Citation and Details
Article DOI: 10.1016/j.bmcl.2020.127725 BindingDB Entry DOI: 10.7270/Q2ZK5M9J |
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 6/G1/S-specific cyclin-D1
(Homo sapiens (Human)) | BDBM50549560
(CHEMBL4752087)Show SMILES Cc1ccccc1NC(=O)c1cc2cnc(Nc3ccc(cn3)N3CCNCC3)nc2n1C1CCCC1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 64 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of CDK6/cyclin D1 (unknown origin) |
Citation and Details
Article DOI: 10.1016/j.bmcl.2020.127725 BindingDB Entry DOI: 10.7270/Q2ZK5M9J |
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 6/G1/S-specific cyclin-D1
(Homo sapiens (Human)) | BDBM50549568
(CHEMBL4799064)Show SMILES O=C(Nc1ccccc1)c1cc2cnc(Nc3ccc(cn3)N3CCNCC3)nc2n1C1CCCC1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 64 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of CDK6/cyclin D1 (unknown origin) |
Citation and Details
Article DOI: 10.1016/j.bmcl.2020.127725 BindingDB Entry DOI: 10.7270/Q2ZK5M9J |
More data for this Ligand-Target Pair | |
Reverse transcriptase
(Human immunodeficiency virus 1) | BDBM50103642
(4-(6-amino-5-bromo-2-(4-cyanophenylamino)pyrimidin...)Show SMILES Cc1cc(cc(C)c1Oc1nc(Nc2ccc(cc2)C#N)nc(N)c1Br)C#N Show InChI InChI=1S/C20H15BrN6O/c1-11-7-14(10-23)8-12(2)17(11)28-19-16(21)18(24)26-20(27-19)25-15-5-3-13(9-22)4-6-15/h3-8H,1-2H3,(H3,24,25,26,27) | PDB MMDB
UniProtKB/TrEMBL
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| n/a | n/a | 68 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute-Jewish General Hospital
Curated by ChEMBL
| Assay Description Inhibition of RNA-dependent DNA polymerase activity of wild type HIV1 subtype B reverse transcriptase by filter-based filtration assay |
Antimicrob Agents Chemother 54: 2401-8 (2010)
Article DOI: 10.1128/AAC.01795-09 BindingDB Entry DOI: 10.7270/Q26D5WT1 |
More data for this Ligand-Target Pair | |
Reverse transcriptase
(Human immunodeficiency virus 1) | BDBM2483
((4S)-6-chloro-4-(2-cyclopropylethynyl)-4-(trifluor...)Show SMILES FC(F)(F)[C@]1(OC(=O)Nc2ccc(Cl)cc12)C#CC1CC1 |r| Show InChI InChI=1S/C14H9ClF3NO2/c15-9-3-4-11-10(7-9)13(14(16,17)18,21-12(20)19-11)6-5-8-1-2-8/h3-4,7-8H,1-2H2,(H,19,20)/t13-/m0/s1 | PDB MMDB
UniProtKB/TrEMBL
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| Article PubMed
| n/a | n/a | 93 | n/a | n/a | n/a | n/a | n/a | n/a |
McGill University AIDS Centre
Curated by ChEMBL
| Assay Description Inhibition of RNA-dependent DNA polymerase activity of wild-type Human immunodeficiency virus 1 subtype B reverse transcriptase by filter-based filtr... |
Antimicrob Agents Chemother 53: 4667-72 (2009)
Article DOI: 10.1128/AAC.00800-09 BindingDB Entry DOI: 10.7270/Q2FN191R |
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1
(Homo sapiens (Human)) | BDBM50549578
(CHEMBL4791807) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 93 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of CDK4/cyclin D1 (unknown origin) |
Citation and Details
Article DOI: 10.1016/j.bmcl.2020.127725 BindingDB Entry DOI: 10.7270/Q2ZK5M9J |
More data for this Ligand-Target Pair | |
Reverse transcriptase
(Human immunodeficiency virus 1) | BDBM50103642
(4-(6-amino-5-bromo-2-(4-cyanophenylamino)pyrimidin...)Show SMILES Cc1cc(cc(C)c1Oc1nc(Nc2ccc(cc2)C#N)nc(N)c1Br)C#N Show InChI InChI=1S/C20H15BrN6O/c1-11-7-14(10-23)8-12(2)17(11)28-19-16(21)18(24)26-20(27-19)25-15-5-3-13(9-22)4-6-15/h3-8H,1-2H3,(H3,24,25,26,27) | PDB MMDB
UniProtKB/TrEMBL
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| Article PubMed
| n/a | n/a | 97 | n/a | n/a | n/a | n/a | n/a | n/a |
McGill University AIDS Centre
Curated by ChEMBL
| Assay Description Inhibition of Human immunodeficiency virus 1 subtype B reverse transcriptase DNA-dependent DNA polymerase activity by gel-based primer extension assa... |
Antimicrob Agents Chemother 53: 4667-72 (2009)
Article DOI: 10.1128/AAC.00800-09 BindingDB Entry DOI: 10.7270/Q2FN191R |
More data for this Ligand-Target Pair | |
Reverse transcriptase
(Human immunodeficiency virus 1) | BDBM50103642
(4-(6-amino-5-bromo-2-(4-cyanophenylamino)pyrimidin...)Show SMILES Cc1cc(cc(C)c1Oc1nc(Nc2ccc(cc2)C#N)nc(N)c1Br)C#N Show InChI InChI=1S/C20H15BrN6O/c1-11-7-14(10-23)8-12(2)17(11)28-19-16(21)18(24)26-20(27-19)25-15-5-3-13(9-22)4-6-15/h3-8H,1-2H3,(H3,24,25,26,27) | PDB MMDB
UniProtKB/TrEMBL
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Patents
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| Article PubMed
| n/a | n/a | 107 | n/a | n/a | n/a | n/a | n/a | n/a |
McGill University AIDS Centre
Curated by ChEMBL
| Assay Description Inhibition of DNA-dependent DNA polymerase activity of wild-type Human immunodeficiency virus 1 subtype B reverse transcriptase Y181C mutant by filte... |
Antimicrob Agents Chemother 53: 4667-72 (2009)
Article DOI: 10.1128/AAC.00800-09 BindingDB Entry DOI: 10.7270/Q2FN191R |
More data for this Ligand-Target Pair | |
Reverse transcriptase protein
(Human immunodeficiency virus 1) | BDBM2483
((4S)-6-chloro-4-(2-cyclopropylethynyl)-4-(trifluor...)Show SMILES FC(F)(F)[C@]1(OC(=O)Nc2ccc(Cl)cc12)C#CC1CC1 |r| Show InChI InChI=1S/C14H9ClF3NO2/c15-9-3-4-11-10(7-9)13(14(16,17)18,21-12(20)19-11)6-5-8-1-2-8/h3-4,7-8H,1-2H2,(H,19,20)/t13-/m0/s1 | PDB MMDB
UniProtKB/TrEMBL
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| Article PubMed
| n/a | n/a | 112 | n/a | n/a | n/a | n/a | n/a | n/a |
McGill University AIDS Centre
Curated by ChEMBL
| Assay Description Inhibition of Human immunodeficiency virus 1 subtype B reverse transcriptase G190A mutant by filter-based filtration assay |
Antimicrob Agents Chemother 53: 4667-72 (2009)
Article DOI: 10.1128/AAC.00800-09 BindingDB Entry DOI: 10.7270/Q2FN191R |
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1
(Homo sapiens (Human)) | BDBM50549564
(CHEMBL4782842)Show SMILES COc1ccc(NC(=O)c2cc3cnc(Nc4ccc(cn4)N4CCNCC4)nc3n2C2CCCC2)cc1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 121 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of CDK4/cyclin D1 (unknown origin) |
Citation and Details
Article DOI: 10.1016/j.bmcl.2020.127725 BindingDB Entry DOI: 10.7270/Q2ZK5M9J |
More data for this Ligand-Target Pair | |
Reverse transcriptase
(Human immunodeficiency virus 1) | BDBM2483
((4S)-6-chloro-4-(2-cyclopropylethynyl)-4-(trifluor...)Show SMILES FC(F)(F)[C@]1(OC(=O)Nc2ccc(Cl)cc12)C#CC1CC1 |r| Show InChI InChI=1S/C14H9ClF3NO2/c15-9-3-4-11-10(7-9)13(14(16,17)18,21-12(20)19-11)6-5-8-1-2-8/h3-4,7-8H,1-2H2,(H,19,20)/t13-/m0/s1 | PDB MMDB
UniProtKB/TrEMBL
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CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 126 | n/a | n/a | n/a | n/a | n/a | n/a |
McGill University AIDS Centre
Curated by ChEMBL
| Assay Description Inhibition of Human immunodeficiency virus 1 subtype B reverse transcriptase Y181C mutant by filter-based filtration assay |
Antimicrob Agents Chemother 53: 4667-72 (2009)
Article DOI: 10.1128/AAC.00800-09 BindingDB Entry DOI: 10.7270/Q2FN191R |
More data for this Ligand-Target Pair | |
Reverse transcriptase
(Human immunodeficiency virus 1) | BDBM50103642
(4-(6-amino-5-bromo-2-(4-cyanophenylamino)pyrimidin...)Show SMILES Cc1cc(cc(C)c1Oc1nc(Nc2ccc(cc2)C#N)nc(N)c1Br)C#N Show InChI InChI=1S/C20H15BrN6O/c1-11-7-14(10-23)8-12(2)17(11)28-19-16(21)18(24)26-20(27-19)25-15-5-3-13(9-22)4-6-15/h3-8H,1-2H3,(H3,24,25,26,27) | PDB MMDB
UniProtKB/TrEMBL
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CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem
Patents
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| Article PubMed
| n/a | n/a | 126 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute-Jewish General Hospital
Curated by ChEMBL
| Assay Description Inhibition of DNA-dependent DNA polymerase activity of wild type HIV1 subtype B reverse transcriptase by gel-based primer extension assay |
Antimicrob Agents Chemother 54: 2401-8 (2010)
Article DOI: 10.1128/AAC.01795-09 BindingDB Entry DOI: 10.7270/Q26D5WT1 |
More data for this Ligand-Target Pair | |
Reverse transcriptase protein
(Human immunodeficiency virus 1) | BDBM50103642
(4-(6-amino-5-bromo-2-(4-cyanophenylamino)pyrimidin...)Show SMILES Cc1cc(cc(C)c1Oc1nc(Nc2ccc(cc2)C#N)nc(N)c1Br)C#N Show InChI InChI=1S/C20H15BrN6O/c1-11-7-14(10-23)8-12(2)17(11)28-19-16(21)18(24)26-20(27-19)25-15-5-3-13(9-22)4-6-15/h3-8H,1-2H3,(H3,24,25,26,27) | PDB MMDB
UniProtKB/TrEMBL
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CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem
Patents
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| Article PubMed
| n/a | n/a | 129 | n/a | n/a | n/a | n/a | n/a | n/a |
McGill University AIDS Centre
Curated by ChEMBL
| Assay Description Inhibition of DNA-dependent DNA polymerase activity of wild-type Human immunodeficiency virus 1 subtype B reverse transcriptase G190A mutant by filte... |
Antimicrob Agents Chemother 53: 4667-72 (2009)
Article DOI: 10.1128/AAC.00800-09 BindingDB Entry DOI: 10.7270/Q2FN191R |
More data for this Ligand-Target Pair | |
Reverse transcriptase
(Human immunodeficiency virus 1) | BDBM50467334
(AIDS-105293 | Dapivirine | R-147681 | TMC-120)Show InChI InChI=1S/C20H19N5/c1-13-10-14(2)19(15(3)11-13)24-18-8-9-22-20(25-18)23-17-6-4-16(12-21)5-7-17/h4-11H,1-3H3,(H2,22,23,24,25) | PDB MMDB
UniProtKB/TrEMBL
B.MOAD GoogleScholar AffyNet
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MCE PC cid PC sid PDB UniChem
| Article PubMed
| n/a | n/a | 131 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute-Jewish General Hospital
Curated by ChEMBL
| Assay Description Inhibition of DNA-dependent DNA polymerase activity of wild type HIV1 subtype B reverse transcriptase by gel-based primer extension assay |
Antimicrob Agents Chemother 54: 2401-8 (2010)
Article DOI: 10.1128/AAC.01795-09 BindingDB Entry DOI: 10.7270/Q26D5WT1 |
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1
(Homo sapiens (Human)) | BDBM50549577
(CHEMBL4761061)Show SMILES CN(C)C(=O)c1cc2cnc(Nc3ccc(Cl)cc3)nc2n1C1CCCC1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 143 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of CDK4/cyclin D1 (unknown origin) |
Citation and Details
Article DOI: 10.1016/j.bmcl.2020.127725 BindingDB Entry DOI: 10.7270/Q2ZK5M9J |
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1
(Homo sapiens (Human)) | BDBM50549575
(CHEMBL4746355)Show SMILES CN(C)C(=O)c1cc2cnc(Nc3ccc(cc3)S(=O)(=O)Nc3nc(C)cc(C)n3)nc2n1C1CCCC1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 150 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of CDK4/cyclin D1 (unknown origin) |
Citation and Details
Article DOI: 10.1016/j.bmcl.2020.127725 BindingDB Entry DOI: 10.7270/Q2ZK5M9J |
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 6/G1/S-specific cyclin-D1
(Homo sapiens (Human)) | BDBM50549566
(CHEMBL4743047)Show SMILES COc1cccc(NC(=O)c2cc3cnc(Nc4ccc(cn4)N4CCNCC4)nc3n2C2CCCC2)c1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 169 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of CDK6/cyclin D1 (unknown origin) |
Citation and Details
Article DOI: 10.1016/j.bmcl.2020.127725 BindingDB Entry DOI: 10.7270/Q2ZK5M9J |
More data for this Ligand-Target Pair | |
Reverse transcriptase protein
(Human immunodeficiency virus 1) | BDBM50467334
(AIDS-105293 | Dapivirine | R-147681 | TMC-120)Show InChI InChI=1S/C20H19N5/c1-13-10-14(2)19(15(3)11-13)24-18-8-9-22-20(25-18)23-17-6-4-16(12-21)5-7-17/h4-11H,1-3H3,(H2,22,23,24,25) | PDB MMDB
UniProtKB/TrEMBL
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MCE PC cid PC sid PDB UniChem
| Article PubMed
| n/a | n/a | 172 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute-Jewish General Hospital
Curated by ChEMBL
| Assay Description Inhibition of RNA-dependent DNA polymerase activity of HIV1 subtype B reverse transcriptase M230L mutant by filter-based filtration assay |
Antimicrob Agents Chemother 54: 2401-8 (2010)
Article DOI: 10.1128/AAC.01795-09 BindingDB Entry DOI: 10.7270/Q26D5WT1 |
More data for this Ligand-Target Pair | |
Reverse transcriptase
(Human immunodeficiency virus 1) | BDBM50103642
(4-(6-amino-5-bromo-2-(4-cyanophenylamino)pyrimidin...)Show SMILES Cc1cc(cc(C)c1Oc1nc(Nc2ccc(cc2)C#N)nc(N)c1Br)C#N Show InChI InChI=1S/C20H15BrN6O/c1-11-7-14(10-23)8-12(2)17(11)28-19-16(21)18(24)26-20(27-19)25-15-5-3-13(9-22)4-6-15/h3-8H,1-2H3,(H3,24,25,26,27) | PDB MMDB
UniProtKB/TrEMBL
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CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 175 | n/a | n/a | n/a | n/a | n/a | n/a |
McGill University AIDS Centre
Curated by ChEMBL
| Assay Description Inhibition of RNA-dependent DNA polymerase activity of wild-type Human immunodeficiency virus 1 subtype B reverse transcriptase by filter-based filtr... |
Antimicrob Agents Chemother 53: 4667-72 (2009)
Article DOI: 10.1128/AAC.00800-09 BindingDB Entry DOI: 10.7270/Q2FN191R |
More data for this Ligand-Target Pair | |
Reverse transcriptase protein
(Human immunodeficiency virus 1) | BDBM50103642
(4-(6-amino-5-bromo-2-(4-cyanophenylamino)pyrimidin...)Show SMILES Cc1cc(cc(C)c1Oc1nc(Nc2ccc(cc2)C#N)nc(N)c1Br)C#N Show InChI InChI=1S/C20H15BrN6O/c1-11-7-14(10-23)8-12(2)17(11)28-19-16(21)18(24)26-20(27-19)25-15-5-3-13(9-22)4-6-15/h3-8H,1-2H3,(H3,24,25,26,27) | PDB MMDB
UniProtKB/TrEMBL
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CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem
Patents
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| Article PubMed
| n/a | n/a | 191 | n/a | n/a | n/a | n/a | n/a | n/a |
McGill University AIDS Centre
Curated by ChEMBL
| Assay Description Inhibition of Human immunodeficiency virus 1 subtype B reverse transcriptase G190A mutant by filter-based filtration assay |
Antimicrob Agents Chemother 53: 4667-72 (2009)
Article DOI: 10.1128/AAC.00800-09 BindingDB Entry DOI: 10.7270/Q2FN191R |
More data for this Ligand-Target Pair | |
Reverse transcriptase protein
(Human immunodeficiency virus 1) | BDBM2483
((4S)-6-chloro-4-(2-cyclopropylethynyl)-4-(trifluor...)Show SMILES FC(F)(F)[C@]1(OC(=O)Nc2ccc(Cl)cc12)C#CC1CC1 |r| Show InChI InChI=1S/C14H9ClF3NO2/c15-9-3-4-11-10(7-9)13(14(16,17)18,21-12(20)19-11)6-5-8-1-2-8/h3-4,7-8H,1-2H2,(H,19,20)/t13-/m0/s1 | PDB MMDB
UniProtKB/TrEMBL
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CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
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| Article PubMed
| n/a | n/a | 216 | n/a | n/a | n/a | n/a | n/a | n/a |
McGill University AIDS Centre
Curated by ChEMBL
| Assay Description Inhibition of DNA-dependent DNA polymerase activity of wild-type Human immunodeficiency virus 1 subtype B reverse transcriptase G190A mutant by filte... |
Antimicrob Agents Chemother 53: 4667-72 (2009)
Article DOI: 10.1128/AAC.00800-09 BindingDB Entry DOI: 10.7270/Q2FN191R |
More data for this Ligand-Target Pair | |
Reverse transcriptase
(Human immunodeficiency virus 1) | BDBM50103642
(4-(6-amino-5-bromo-2-(4-cyanophenylamino)pyrimidin...)Show SMILES Cc1cc(cc(C)c1Oc1nc(Nc2ccc(cc2)C#N)nc(N)c1Br)C#N Show InChI InChI=1S/C20H15BrN6O/c1-11-7-14(10-23)8-12(2)17(11)28-19-16(21)18(24)26-20(27-19)25-15-5-3-13(9-22)4-6-15/h3-8H,1-2H3,(H3,24,25,26,27) | PDB MMDB
UniProtKB/TrEMBL
B.MOAD GoogleScholar AffyNet
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CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 257 | n/a | n/a | n/a | n/a | n/a | n/a |
McGill University AIDS Centre
Curated by ChEMBL
| Assay Description Inhibition of Human immunodeficiency virus 1 subtype B reverse transcriptase Y181C mutant by filter-based filtration assay |
Antimicrob Agents Chemother 53: 4667-72 (2009)
Article DOI: 10.1128/AAC.00800-09 BindingDB Entry DOI: 10.7270/Q2FN191R |
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 6/G1/S-specific cyclin-D1
(Homo sapiens (Human)) | BDBM50549565
(CHEMBL4749923)Show SMILES COc1ccc(NC(=O)c2cc3cnc(Nc4ccc(cn4)N4CCNCC4)nc3n2C2CCCC2)c(OC)c1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 268 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of CDK6/cyclin D1 (unknown origin) |
Citation and Details
Article DOI: 10.1016/j.bmcl.2020.127725 BindingDB Entry DOI: 10.7270/Q2ZK5M9J |
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1
(Homo sapiens (Human)) | BDBM50549576
(CHEMBL4796853) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 315 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of CDK4/cyclin D1 (unknown origin) |
Citation and Details
Article DOI: 10.1016/j.bmcl.2020.127725 BindingDB Entry DOI: 10.7270/Q2ZK5M9J |
More data for this Ligand-Target Pair | |
Reverse transcriptase protein
(Human immunodeficiency virus 1) | BDBM50467334
(AIDS-105293 | Dapivirine | R-147681 | TMC-120)Show InChI InChI=1S/C20H19N5/c1-13-10-14(2)19(15(3)11-13)24-18-8-9-22-20(25-18)23-17-6-4-16(12-21)5-7-17/h4-11H,1-3H3,(H2,22,23,24,25) | PDB MMDB
UniProtKB/TrEMBL
B.MOAD GoogleScholar AffyNet
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MCE PC cid PC sid PDB UniChem
| Article PubMed
| n/a | n/a | 316 | n/a | n/a | n/a | n/a | n/a | n/a |
McGill University AIDS Centre
Curated by ChEMBL
| Assay Description Inhibition of DNA-dependent DNA polymerase activity of wild-type Human immunodeficiency virus 1 subtype B reverse transcriptase G190A mutant by filte... |
Antimicrob Agents Chemother 53: 4667-72 (2009)
Article DOI: 10.1128/AAC.00800-09 BindingDB Entry DOI: 10.7270/Q2FN191R |
More data for this Ligand-Target Pair | |
Reverse transcriptase
(Human immunodeficiency virus 1) | BDBM50467334
(AIDS-105293 | Dapivirine | R-147681 | TMC-120)Show InChI InChI=1S/C20H19N5/c1-13-10-14(2)19(15(3)11-13)24-18-8-9-22-20(25-18)23-17-6-4-16(12-21)5-7-17/h4-11H,1-3H3,(H2,22,23,24,25) | PDB MMDB
UniProtKB/TrEMBL
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MCE PC cid PC sid PDB UniChem
| Article PubMed
| n/a | n/a | 322 | n/a | n/a | n/a | n/a | n/a | n/a |
McGill University AIDS Centre
Curated by ChEMBL
| Assay Description Inhibition of Human immunodeficiency virus 1 subtype B reverse transcriptase DNA-dependent DNA polymerase activity by gel-based primer extension assa... |
Antimicrob Agents Chemother 53: 4667-72 (2009)
Article DOI: 10.1128/AAC.00800-09 BindingDB Entry DOI: 10.7270/Q2FN191R |
More data for this Ligand-Target Pair | |