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Compile Data Set for Download or QSAR

Found 1111 hits with Last Name = 'richards' and Initial = 'p'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))		BDBM299749
PNG
(4-[4-({[2-amino-5- (1-methyl-1H- imidazol-4- yl)py...)
Show SMILES Cn1cnc(c1)-c1cnc(N)c(OCC2CCN(CC2)c2nc(OCC3(CC3)C#N)nc(n2)C(=O)NC23CC(C2)C3)c1
Show InChI InChI=1S/C29H34N10O3/c1-38-13-21(33-17-38)20-8-22(23(31)32-12-20)41-14-18-2-6-39(7-3-18)26-34-24(25(40)37-29-9-19(10-29)11-29)35-27(36-26)42-16-28(15-30)4-5-28/h8,12-13,17-19H,2-7,9-11,14,16H2,1H3,(H2,31,32)(H,37,40)
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 0.0100n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
AXL enzyme inhibition (% inhibition, Kiapp and Ki values) by small molecule inhibitors was evaluated using a fluorescence-based microfluidic mobility...

US Patent US9593097 (2017)


BindingDB Entry DOI: 10.7270/Q2GM89BD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))		BDBM299902
PNG
(6-[4-({[2-amino-5- (1-methyl-1H- imidazol-4- yl)py...)
Show SMILES C[C@H](CO)NC(=O)c1nc(OC[C@H]2CCCO2)nc(n1)N1CCC(COc2cc(cnc2N)-c2cn(C)cn2)CC1 |r|
Show InChI InChI=1S/C27H37N9O5/c1-17(13-37)31-25(38)24-32-26(34-27(33-24)41-15-20-4-3-9-39-20)36-7-5-18(6-8-36)14-40-22-10-19(11-29-23(22)28)21-12-35(2)16-30-21/h10-12,16-18,20,37H,3-9,13-15H2,1-2H3,(H2,28,29)(H,31,38)/t17-,20-/m1/s1
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 0.0120n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
AXL enzyme inhibition (% inhibition, Kiapp and Ki values) by small molecule inhibitors was evaluated using a fluorescence-based microfluidic mobility...

US Patent US9593097 (2017)


BindingDB Entry DOI: 10.7270/Q2GM89BD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))		BDBM299975
PNG
(4-[4-({[2-amino-5- (1-methyl-1H- imidazol-4- yl)py...)
Show SMILES Cn1cnc(c1)-c1cnc(N)c(OCC2CCN(CC2)c2nc(OCC3(CC3)C#N)nc(n2)C(=O)NC2(C)CCC2)c1
Show InChI InChI=1S/C29H36N10O3/c1-28(6-3-7-28)37-25(40)24-34-26(36-27(35-24)42-17-29(16-30)8-9-29)39-10-4-19(5-11-39)15-41-22-12-20(13-32-23(22)31)21-14-38(2)18-33-21/h12-14,18-19H,3-11,15,17H2,1-2H3,(H2,31,32)(H,37,40)
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 0.0120n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
AXL enzyme inhibition (% inhibition, Kiapp and Ki values) by small molecule inhibitors was evaluated using a fluorescence-based microfluidic mobility...

US Patent US9593097 (2017)


BindingDB Entry DOI: 10.7270/Q2GM89BD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))		BDBM300035
PNG
(2-(benzyloxy)-N- [(2R)-1- hydroxypropan-2- yl]-6-[...)
Show SMILES COc1ccnc2[nH]nc(C3CCN(CC3)c3cc(nc(OCc4ccccc4)n3)C(=O)N[C@H](C)CO)c12 |r|
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<0.0130n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
AXL enzyme inhibition (% inhibition, Kiapp and Ki values) by small molecule inhibitors was evaluated using a fluorescence-based microfluidic mobility...

US Patent US9593097 (2017)


BindingDB Entry DOI: 10.7270/Q2GM89BD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))		BDBM300011
PNG
(4-[4-({[2-amino-5- (1-methyl-1H- imidazol-4- yl)py...)
Show SMILES C[C@H](NC(=O)c1nc(OCC2CC2)nc(n1)N1CCC(COc2cc(cnc2N)-c2cn(C)cn2)CC1)C(F)(F)F |r|
Show InChI InChI=1S/C26H32F3N9O3/c1-15(26(27,28)29)33-23(39)22-34-24(36-25(35-22)41-13-16-3-4-16)38-7-5-17(6-8-38)12-40-20-9-18(10-31-21(20)30)19-11-37(2)14-32-19/h9-11,14-17H,3-8,12-13H2,1-2H3,(H2,30,31)(H,33,39)/t15-/m0/s1
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<0.0130n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
AXL enzyme inhibition (% inhibition, Kiapp and Ki values) by small molecule inhibitors was evaluated using a fluorescence-based microfluidic mobility...

US Patent US9593097 (2017)


BindingDB Entry DOI: 10.7270/Q2GM89BD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))		BDBM300077
PNG
(N-(3-amino-3- methylbutan- 2-yl)-2- (cyclo- propyl...)
Show SMILES COc1ccnc2[nH]cc(C3CCN(CC3)c3cc(nc(OCC4CC4)n3)C(=O)NC(C)C(C)(C)N)c12
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<0.0130n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
AXL enzyme inhibition (% inhibition, Kiapp and Ki values) by small molecule inhibitors was evaluated using a fluorescence-based microfluidic mobility...

US Patent US9593097 (2017)


BindingDB Entry DOI: 10.7270/Q2GM89BD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))		BDBM300079
PNG
(N-[(2R)-1- hydroxypropan-2- yl]-6-[4-(4- methoxy-1...)
Show SMILES COc1ccnc2[nH]cc(C3CCN(CC3)c3cc(nc(OC[C@H]4CCCO4)n3)C(=O)N[C@H](C)CO)c12 |r|
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<0.0130n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
AXL enzyme inhibition (% inhibition, Kiapp and Ki values) by small molecule inhibitors was evaluated using a fluorescence-based microfluidic mobility...

US Patent US9593097 (2017)


BindingDB Entry DOI: 10.7270/Q2GM89BD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))		BDBM300088
PNG
(N-[(2R)-1- hydroxypropan-2- yl]-2-[(2R)-2- methoxy...)
Show SMILES CO[C@H](C)COc1nc(cc(n1)C(=O)N[C@H](C)CO)N1CCC(CC1)c1c[nH]c2nccc(OC)c12 |r|
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 0.0140n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
AXL enzyme inhibition (% inhibition, Kiapp and Ki values) by small molecule inhibitors was evaluated using a fluorescence-based microfluidic mobility...

US Patent US9593097 (2017)


BindingDB Entry DOI: 10.7270/Q2GM89BD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))		BDBM299931
PNG
(4-[4-({[2-amino-5- (1-methyl-1H- imidazol-4- yl)py...)
Show SMILES CC(C)NC(=O)c1nc(OC[C@H]2CC2(F)F)nc(n1)N1CCC(COc2cc(cnc2N)-c2cn(C)cn2)CC1 |r|
Show InChI InChI=1S/C26H33F2N9O3/c1-15(2)32-23(38)22-33-24(35-25(34-22)40-13-18-9-26(18,27)28)37-6-4-16(5-7-37)12-39-20-8-17(10-30-21(20)29)19-11-36(3)14-31-19/h8,10-11,14-16,18H,4-7,9,12-13H2,1-3H3,(H2,29,30)(H,32,38)/t18-/m1/s1
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 0.0150n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
AXL enzyme inhibition (% inhibition, Kiapp and Ki values) by small molecule inhibitors was evaluated using a fluorescence-based microfluidic mobility...

US Patent US9593097 (2017)


BindingDB Entry DOI: 10.7270/Q2GM89BD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))		BDBM299998
PNG
(N-[(2R)-1- hydroxypropan-2- yl]-6-[4-(4- methoxy-1...)
Show SMILES COc1ccnc2[nH]nc(C3CCN(CC3)c3cc(nc(OC[C@H]4CCCO4)n3)C(=O)N[C@H](C)CO)c12 |r|
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 0.0150n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
AXL enzyme inhibition (% inhibition, Kiapp and Ki values) by small molecule inhibitors was evaluated using a fluorescence-based microfluidic mobility...

US Patent US9593097 (2017)


BindingDB Entry DOI: 10.7270/Q2GM89BD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))		BDBM300012
PNG
(N-(2- methoxyethyl)-6- [4-(4-methoxy-1H- pyrrolo[2...)
Show SMILES COCCNC(=O)c1cc(nc(OC[C@H]2CCCO2)n1)N1CCC(CC1)c1c[nH]c2nccc(OC)c12 |r|
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 0.0160n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
AXL enzyme inhibition (% inhibition, Kiapp and Ki values) by small molecule inhibitors was evaluated using a fluorescence-based microfluidic mobility...

US Patent US9593097 (2017)


BindingDB Entry DOI: 10.7270/Q2GM89BD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))		BDBM299909
PNG
(4-[4-({[2-amino-5- (1-methyl-1H- imidazol-4- yl)py...)
Show SMILES C[C@H](NC(=O)c1nc(OC[C@H]2CCCO2)nc(n1)N1CCC(COc2cc(cnc2N)-c2cn(C)cn2)CC1)C(F)(F)F |r|
Show InChI InChI=1S/C27H34F3N9O4/c1-16(27(28,29)30)34-24(40)23-35-25(37-26(36-23)43-14-19-4-3-9-41-19)39-7-5-17(6-8-39)13-42-21-10-18(11-32-22(21)31)20-12-38(2)15-33-20/h10-12,15-17,19H,3-9,13-14H2,1-2H3,(H2,31,32)(H,34,40)/t16-,19+/m0/s1
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Pfizer Inc.

US Patent


Assay Description
AXL enzyme inhibition (% inhibition, Kiapp and Ki values) by small molecule inhibitors was evaluated using a fluorescence-based microfluidic mobility...

US Patent US9593097 (2017)


BindingDB Entry DOI: 10.7270/Q2GM89BD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))		BDBM299744
PNG
(4-[4-({[2-amino-5- (1-methyl-1H- imidazol-4- yl)py...)
Show SMILES Cn1cnc(c1)-c1cnc(N)c(OCC2CCN(CC2)c2nc(OCC3(CC3)C#N)nc(n2)C(=O)NC2CCC2)c1
Show InChI InChI=1S/C28H34N10O3/c1-37-13-21(32-17-37)19-11-22(23(30)31-12-19)40-14-18-5-9-38(10-6-18)26-34-24(25(39)33-20-3-2-4-20)35-27(36-26)41-16-28(15-29)7-8-28/h11-13,17-18,20H,2-10,14,16H2,1H3,(H2,30,31)(H,33,39)
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 0.0160n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
AXL enzyme inhibition (% inhibition, Kiapp and Ki values) by small molecule inhibitors was evaluated using a fluorescence-based microfluidic mobility...

US Patent US9593097 (2017)


BindingDB Entry DOI: 10.7270/Q2GM89BD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))		BDBM300007
PNG
(2-[(1- cyanocyclopropyl) methoxy]-N-[(2R)- 1-hydro...)
Show SMILES COc1ccnc2[nH]cc(C3CCN(CC3)c3cc(nc(OCC4(CC4)C#N)n3)C(=O)N[C@H](C)CO)c12 |r|
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<0.0180n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
AXL enzyme inhibition (% inhibition, Kiapp and Ki values) by small molecule inhibitors was evaluated using a fluorescence-based microfluidic mobility...

US Patent US9593097 (2017)


BindingDB Entry DOI: 10.7270/Q2GM89BD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))		BDBM300049
PNG
((3,3- difluoroazetidin-1- yl)(2-{[(2R)-1- methoxyp...)
Show SMILES COC[C@@H](C)Oc1nc(cc(n1)C(=O)N1CC(F)(F)C1)N1CCC(CC1)c1c[nH]c2nccc(OC)c12 |r|
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 0.0180n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
AXL enzyme inhibition (% inhibition, Kiapp and Ki values) by small molecule inhibitors was evaluated using a fluorescence-based microfluidic mobility...

US Patent US9593097 (2017)


BindingDB Entry DOI: 10.7270/Q2GM89BD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))		BDBM299893
PNG
(4-[4-({[2-amino-5- (1-methyl-1H- imidazol-4- yl)py...)
Show SMILES C[C@@H](NC(=O)c1nc(OCC2(CC2)C#N)nc(n1)N1CCC(COc2cc(cnc2N)-c2cn(C)cn2)CC1)C1CC1 |r|
Show InChI InChI=1S/C29H36N10O3/c1-18(20-3-4-20)34-26(40)25-35-27(37-28(36-25)42-16-29(15-30)7-8-29)39-9-5-19(6-10-39)14-41-23-11-21(12-32-24(23)31)22-13-38(2)17-33-22/h11-13,17-20H,3-10,14,16H2,1-2H3,(H2,31,32)(H,34,40)/t18-/m1/s1
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 0.0190n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
AXL enzyme inhibition (% inhibition, Kiapp and Ki values) by small molecule inhibitors was evaluated using a fluorescence-based microfluidic mobility...

US Patent US9593097 (2017)


BindingDB Entry DOI: 10.7270/Q2GM89BD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))		BDBM300090
PNG
(N-[(2R)-1- hydroxypropan-2- yl]-2-[(2S)-2- methoxy...)
Show SMILES CO[C@@H](C)COc1nc(cc(n1)C(=O)N[C@H](C)CO)N1CCC(CC1)c1c[nH]c2nccc(OC)c12 |r|
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 0.0200n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
AXL enzyme inhibition (% inhibition, Kiapp and Ki values) by small molecule inhibitors was evaluated using a fluorescence-based microfluidic mobility...

US Patent US9593097 (2017)


BindingDB Entry DOI: 10.7270/Q2GM89BD
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase ROS


(Homo sapiens (Human))		BDBM50018830
PNG
(CHEMBL3286830 | US10543199, Compound PF-06463922 |...)
Show SMILES C[C@H]1Oc2cc(cnc2N)-c2c(CN(C)C(=O)c3ccc(F)cc13)nn(C)c2C#N |r|
Show InChI InChI=1S/C21H19FN6O2/c1-11-15-7-13(22)4-5-14(15)21(29)27(2)10-16-19(17(8-23)28(3)26-16)12-6-18(30-11)20(24)25-9-12/h4-7,9,11H,10H2,1-3H3,(H2,24,25)/t11-/m1/s1
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<0.0200n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of ROS1 (unknown origin) by off-chip mobility shift assay

J Med Chem 57: 4720-44 (2014)


Article DOI: 10.1021/jm500261q
BindingDB Entry DOI: 10.7270/Q2K35W68
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))		BDBM50018836
PNG
(CHEMBL3286826)
Show SMILES COc1nn(C)c2CN(C)C(=O)c3ccc(F)cc3[C@@H](C)Oc3nc(cnc3N)-c12 |r|
Show InChI InChI=1S/C20H21FN6O3/c1-10-13-7-11(21)5-6-12(13)20(28)26(2)9-15-16(18(29-4)25-27(15)3)14-8-23-17(22)19(24-14)30-10/h5-8,10H,9H2,1-4H3,(H2,22,23)/t10-/m1/s1
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<0.0200n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant ALK L1196M mutant kinase domain (amino acids 1093 to 1141) expressed in baculovirus system using 5'FAM-KKSRGDYMTMQIG-...

J Med Chem 57: 4720-44 (2014)


Article DOI: 10.1021/jm500261q
BindingDB Entry DOI: 10.7270/Q2K35W68
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase ROS


(Homo sapiens (Human))		BDBM50448785
PNG
(CHEMBL3128069)
Show SMILES C[C@@H](Oc1cc(cnc1N)-c1sc(nc1C)[C@](C)(O)CO)c1cc(F)ccc1-n1nccn1 |r|
Show InChI InChI=1S/C22H23FN6O3S/c1-12-19(33-21(28-12)22(3,31)11-30)14-8-18(20(24)25-10-14)32-13(2)16-9-15(23)4-5-17(16)29-26-6-7-27-29/h4-10,13,30-31H,11H2,1-3H3,(H2,24,25)/t13-,22-/m1/s1
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Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of ROS1 (unknown origin) by Pfizer mobility shift assay

J Med Chem 57: 1170-87 (2014)


Article DOI: 10.1021/jm401805h
BindingDB Entry DOI: 10.7270/Q29C6ZX5
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))		BDBM300070
PNG
(N-[(2R)-3- hydroxy-3- methylbutan-2-yl]- 4-[4-(4-m...)
Show SMILES COc1ccnc2[nH]cc(C3CCN(CC3)c3nc(OC[C@H]4CCCO4)nc(n3)C(=O)N[C@H](C)C(C)(C)O)c12 |r|
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Pfizer Inc.

US Patent


Assay Description
AXL enzyme inhibition (% inhibition, Kiapp and Ki values) by small molecule inhibitors was evaluated using a fluorescence-based microfluidic mobility...

US Patent US9593097 (2017)


BindingDB Entry DOI: 10.7270/Q2GM89BD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))		BDBM299917
PNG
(4-[4-({[2-amino-5- (1-methyl-1H- imidazol-4- yl)py...)
Show SMILES Cn1cnc(c1)-c1cnc(N)c(OCC2CCN(CC2)c2nc(OCC3(CC3)C#N)nc(n2)C(=O)NC(C)(C)C)c1
Show InChI InChI=1S/C28H36N10O3/c1-27(2,3)36-24(39)23-33-25(35-26(34-23)41-16-28(15-29)7-8-28)38-9-5-18(6-10-38)14-40-21-11-19(12-31-22(21)30)20-13-37(4)17-32-20/h11-13,17-18H,5-10,14,16H2,1-4H3,(H2,30,31)(H,36,39)
PDB

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 0.0200n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
AXL enzyme inhibition (% inhibition, Kiapp and Ki values) by small molecule inhibitors was evaluated using a fluorescence-based microfluidic mobility...

US Patent US9593097 (2017)


BindingDB Entry DOI: 10.7270/Q2GM89BD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))		BDBM299901
PNG
(4-[4-({[2-amino-5- (1-methyl-1H- imidazol-4- yl)py...)
Show SMILES Cn1cnc(c1)-c1cnc(N)c(OCC2CCN(CC2)c2nc(OC[C@H]3C[C@H]3C#N)nc(n2)C(=O)NC(C)(C)C)c1 |r|
Show InChI InChI=1S/C28H36N10O3/c1-28(2,3)36-25(39)24-33-26(35-27(34-24)41-15-20-9-18(20)11-29)38-7-5-17(6-8-38)14-40-22-10-19(12-31-23(22)30)21-13-37(4)16-32-21/h10,12-13,16-18,20H,5-9,14-15H2,1-4H3,(H2,30,31)(H,36,39)/t18-,20+/m0/s1
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Pfizer Inc.

US Patent


Assay Description
AXL enzyme inhibition (% inhibition, Kiapp and Ki values) by small molecule inhibitors was evaluated using a fluorescence-based microfluidic mobility...

US Patent US9593097 (2017)


BindingDB Entry DOI: 10.7270/Q2GM89BD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))		BDBM300125
PNG
(N-cyclobutyl-4- {[(2R)-1- methoxypropan-2- yl]oxy}...)
Show SMILES COC[C@@H](C)Oc1nc(nc(n1)C(=O)NC1CCC1)N1CCC(CC1)c1n[nH]c2nccc(OC)c12 |r|
PDB

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Pfizer Inc.

US Patent


Assay Description
AXL enzyme inhibition (% inhibition, Kiapp and Ki values) by small molecule inhibitors was evaluated using a fluorescence-based microfluidic mobility...

US Patent US9593097 (2017)


BindingDB Entry DOI: 10.7270/Q2GM89BD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))		BDBM299996
PNG
(4-[(1- cyanocyclopropyl) methoxy]-6-[4-(4- methoxy...)
Show SMILES COc1ccnc2[nH]cc(C3CCN(CC3)c3nc(OCC4(CC4)C#N)nc(n3)C(=O)N[C@@H](C)C(F)(F)F)c12 |r|
PDB

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Pfizer Inc.

US Patent


Assay Description
AXL enzyme inhibition (% inhibition, Kiapp and Ki values) by small molecule inhibitors was evaluated using a fluorescence-based microfluidic mobility...

US Patent US9593097 (2017)


BindingDB Entry DOI: 10.7270/Q2GM89BD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))		BDBM300104
PNG
(4-(benzyloxy)-N- [(2R)-1- hydroxypropan-2- yl]-6-[...)
Show SMILES COc1ccnc2[nH]cc(C3CCN(CC3)c3nc(OCc4ccccc4)nc(n3)C(=O)N[C@H](C)CO)c12 |r|
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Pfizer Inc.

US Patent


Assay Description
AXL enzyme inhibition (% inhibition, Kiapp and Ki values) by small molecule inhibitors was evaluated using a fluorescence-based microfluidic mobility...

US Patent US9593097 (2017)


BindingDB Entry DOI: 10.7270/Q2GM89BD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))		BDBM299891
PNG
(4-[4-({[2-amino-5- (1-methyl-1H- imidazol-4- yl)py...)
Show SMILES CC[C@@H](C)NC(=O)c1nc(OCC2(CC2)C#N)nc(n1)N1CCC(COc2cc(cnc2N)-c2cn(C)cn2)CC1 |r|
Show InChI InChI=1S/C28H36N10O3/c1-4-18(2)33-25(39)24-34-26(36-27(35-24)41-16-28(15-29)7-8-28)38-9-5-19(6-10-38)14-40-22-11-20(12-31-23(22)30)21-13-37(3)17-32-21/h11-13,17-19H,4-10,14,16H2,1-3H3,(H2,30,31)(H,33,39)/t18-/m1/s1
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Pfizer Inc.

US Patent


Assay Description
AXL enzyme inhibition (% inhibition, Kiapp and Ki values) by small molecule inhibitors was evaluated using a fluorescence-based microfluidic mobility...

US Patent US9593097 (2017)


BindingDB Entry DOI: 10.7270/Q2GM89BD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))		BDBM299746
PNG
(4-[4-({[2-amino-5- (1-methyl-1H- imidazol-4- yl)py...)
Show SMILES Cn1cnc(c1)-c1cnc(N)c(OCC2CCN(CC2)c2nc(OC[C@H]3C[C@H]3C#N)nc(n2)C(=O)NC23CC(C2)C3)c1 |r|
Show InChI InChI=1S/C29H34N10O3/c1-38-13-22(33-16-38)20-7-23(24(31)32-12-20)41-14-17-2-4-39(5-3-17)27-34-25(26(40)37-29-8-18(9-29)10-29)35-28(36-27)42-15-21-6-19(21)11-30/h7,12-13,16-19,21H,2-6,8-10,14-15H2,1H3,(H2,31,32)(H,37,40)/t18?,19-,21+,29?/m0/s1
PDB

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Pfizer Inc.

US Patent


Assay Description
AXL enzyme inhibition (% inhibition, Kiapp and Ki values) by small molecule inhibitors was evaluated using a fluorescence-based microfluidic mobility...

US Patent US9593097 (2017)


BindingDB Entry DOI: 10.7270/Q2GM89BD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))		BDBM299890
PNG
(4-[4-({[2-amino-5- (1-methyl-1H- imidazol-4- yl)py...)
Show SMILES Cn1cnc(c1)-c1cnc(N)c(OCC2CCN(CC2)c2nc(OCC3(CC3)C#N)nc(n2)C(=O)NCC(C)(C)C)c1
Show InChI InChI=1S/C29H38N10O3/c1-28(2,3)16-33-25(40)24-35-26(37-27(36-24)42-17-29(15-30)7-8-29)39-9-5-19(6-10-39)14-41-22-11-20(12-32-23(22)31)21-13-38(4)18-34-21/h11-13,18-19H,5-10,14,16-17H2,1-4H3,(H2,31,32)(H,33,40)
PDB

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Pfizer Inc.

US Patent


Assay Description
AXL enzyme inhibition (% inhibition, Kiapp and Ki values) by small molecule inhibitors was evaluated using a fluorescence-based microfluidic mobility...

US Patent US9593097 (2017)


BindingDB Entry DOI: 10.7270/Q2GM89BD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))		BDBM300064
PNG
(N-[(2R)-1- hydroxypropan-2- yl]-4-{[(2R)-1- methox...)
Show SMILES COC[C@@H](C)Oc1nc(nc(n1)C(=O)N[C@H](C)CO)N1CCC(CC1)c1c[nH]c2nccc(OC)c12 |r|
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Pfizer Inc.

US Patent


Assay Description
AXL enzyme inhibition (% inhibition, Kiapp and Ki values) by small molecule inhibitors was evaluated using a fluorescence-based microfluidic mobility...

US Patent US9593097 (2017)


BindingDB Entry DOI: 10.7270/Q2GM89BD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))		BDBM299930
PNG
(4-[4-({[2-amino-5- (1-methyl-1H- imidazol-4- yl)py...)
Show SMILES C[C@H](CO)NC(=O)c1nc(OC[C@H]2CC2(F)F)nc(n1)N1CCC(COc2cc(cnc2N)-c2cn(C)cn2)CC1 |r|
Show InChI InChI=1S/C26H33F2N9O4/c1-15(11-38)32-23(39)22-33-24(35-25(34-22)41-13-18-8-26(18,27)28)37-5-3-16(4-6-37)12-40-20-7-17(9-30-21(20)29)19-10-36(2)14-31-19/h7,9-10,14-16,18,38H,3-6,8,11-13H2,1-2H3,(H2,29,30)(H,32,39)/t15-,18-/m1/s1
PDB

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Pfizer Inc.

US Patent


Assay Description
AXL enzyme inhibition (% inhibition, Kiapp and Ki values) by small molecule inhibitors was evaluated using a fluorescence-based microfluidic mobility...

US Patent US9593097 (2017)


BindingDB Entry DOI: 10.7270/Q2GM89BD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))		BDBM300071
PNG
(N-[(2R)-1- hydroxypropan-2- yl]-4-[4-(4- methoxy-1...)
Show SMILES COc1ccnc2[nH]cc(C3CCN(CC3)c3nc(OC[C@H]4CCCO4)nc(n3)C(=O)N[C@H](C)CO)c12 |r|
PDB

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Pfizer Inc.

US Patent


Assay Description
AXL enzyme inhibition (% inhibition, Kiapp and Ki values) by small molecule inhibitors was evaluated using a fluorescence-based microfluidic mobility...

US Patent US9593097 (2017)


BindingDB Entry DOI: 10.7270/Q2GM89BD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))		BDBM300103
PNG
(4-[(1- cyanocyclopropyl) methoxy]-N-[(2R)- 1-hydro...)
Show SMILES COc1ccnc2[nH]cc(C3CCN(CC3)c3nc(OCC4(CC4)C#N)nc(n3)C(=O)N[C@H](C)CO)c12 |r|
PDB

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Pfizer Inc.

US Patent


Assay Description
AXL enzyme inhibition (% inhibition, Kiapp and Ki values) by small molecule inhibitors was evaluated using a fluorescence-based microfluidic mobility...

US Patent US9593097 (2017)


BindingDB Entry DOI: 10.7270/Q2GM89BD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))		BDBM299803
PNG
(N- (bicyclo[1.1.1]pent- 1-yl)-4-{[(1S,2R)- 2- cyan...)
Show SMILES COc1ccnc2[nH]nc(C3CCN(CC3)c3nc(OC[C@H]4C[C@H]4C#N)nc(n3)C(=O)NC34CC(C3)C4)c12 |r|
PDB

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Pfizer Inc.

US Patent


Assay Description
AXL enzyme inhibition (% inhibition, Kiapp and Ki values) by small molecule inhibitors was evaluated using a fluorescence-based microfluidic mobility...

US Patent US9593097 (2017)


BindingDB Entry DOI: 10.7270/Q2GM89BD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))		BDBM299852
PNG
(4-[4-({[2-amino-5- (1-methyl-1H- imidazol-4- yl)py...)
Show SMILES Cn1cnc(c1)-c1cnc(N)c(OCC2CCN(CC2)c2nc(OCC3(CC3)C#N)nc(n2)C(=O)NCC2CC2)c1
Show InChI InChI=1S/C28H34N10O3/c1-37-13-21(33-17-37)20-10-22(23(30)31-12-20)40-14-19-4-8-38(9-5-19)26-34-24(25(39)32-11-18-2-3-18)35-27(36-26)41-16-28(15-29)6-7-28/h10,12-13,17-19H,2-9,11,14,16H2,1H3,(H2,30,31)(H,32,39)
PDB

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 0.0320n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
AXL enzyme inhibition (% inhibition, Kiapp and Ki values) by small molecule inhibitors was evaluated using a fluorescence-based microfluidic mobility...

US Patent US9593097 (2017)


BindingDB Entry DOI: 10.7270/Q2GM89BD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))		BDBM300099
PNG
(4-{[(1S,2R)-2- cyanocyclopropyl] methoxy}-N-[(2R)-...)
Show SMILES COc1ccnc2[nH]cc(C3CCN(CC3)c3nc(OC[C@H]4C[C@H]4C#N)nc(n3)C(=O)N[C@H](C)C(C)(C)O)c12 |r|
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Pfizer Inc.

US Patent


Assay Description
AXL enzyme inhibition (% inhibition, Kiapp and Ki values) by small molecule inhibitors was evaluated using a fluorescence-based microfluidic mobility...

US Patent US9593097 (2017)


BindingDB Entry DOI: 10.7270/Q2GM89BD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))		BDBM299922
PNG
(6-[4-({[2-amino-5- (1-methyl-1H- imidazol-4- yl)py...)
Show SMILES C[C@H](CO)NC(=O)c1cc(nc(OC[C@@H]2CC2(F)F)n1)N1CCC(COc2cc(cnc2N)-c2cn(C)cn2)CC1 |r|
Show InChI InChI=1S/C27H34F2N8O4/c1-16(12-38)33-25(39)20-8-23(35-26(34-20)41-14-19-9-27(19,28)29)37-5-3-17(4-6-37)13-40-22-7-18(10-31-24(22)30)21-11-36(2)15-32-21/h7-8,10-11,15-17,19,38H,3-6,9,12-14H2,1-2H3,(H2,30,31)(H,33,39)/t16-,19+/m1/s1
PDB

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 0.0330n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
AXL enzyme inhibition (% inhibition, Kiapp and Ki values) by small molecule inhibitors was evaluated using a fluorescence-based microfluidic mobility...

US Patent US9593097 (2017)


BindingDB Entry DOI: 10.7270/Q2GM89BD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))		BDBM300087
PNG
(N-[(1R,2R)-2- hydroxy- cyclobutyl]- 6-[4-(4-methox...)
Show SMILES COc1ccnc2[nH]nc(C3CCN(CC3)c3cc(nc(OC[C@H]4CCCO4)n3)C(=O)N[C@@H]3CC[C@H]3O)c12 |r|
PDB

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 0.0340n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
AXL enzyme inhibition (% inhibition, Kiapp and Ki values) by small molecule inhibitors was evaluated using a fluorescence-based microfluidic mobility...

US Patent US9593097 (2017)


BindingDB Entry DOI: 10.7270/Q2GM89BD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))		BDBM299911
PNG
(4-[4-({[2-amino-5- (1-methyl-1H- imidazol-4- yl)py...)
Show SMILES C[C@@H](NC(=O)c1nc(OC[C@H]2CCCO2)nc(n1)N1CCC(COc2cc(cnc2N)-c2cn(C)cn2)CC1)C(C)(C)O |r|
Show InChI InChI=1S/C29H41N9O5/c1-18(29(2,3)40)33-26(39)25-34-27(36-28(35-25)43-16-21-6-5-11-41-21)38-9-7-19(8-10-38)15-42-23-12-20(13-31-24(23)30)22-14-37(4)17-32-22/h12-14,17-19,21,40H,5-11,15-16H2,1-4H3,(H2,30,31)(H,33,39)/t18-,21-/m1/s1
PDB

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Pfizer Inc.

US Patent


Assay Description
AXL enzyme inhibition (% inhibition, Kiapp and Ki values) by small molecule inhibitors was evaluated using a fluorescence-based microfluidic mobility...

US Patent US9593097 (2017)


BindingDB Entry DOI: 10.7270/Q2GM89BD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))		BDBM300056
PNG
(N-(3-amino-3- methylbutan-2-yl)- 2-{[(2R)-1- metho...)
Show SMILES COC[C@@H](C)Oc1nc(cc(n1)C(=O)NC(C)C(C)(C)N)N1CCC(CC1)c1c[nH]c2nccc(OC)c12 |r|
PDB

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Pfizer Inc.

US Patent


Assay Description
AXL enzyme inhibition (% inhibition, Kiapp and Ki values) by small molecule inhibitors was evaluated using a fluorescence-based microfluidic mobility...

US Patent US9593097 (2017)


BindingDB Entry DOI: 10.7270/Q2GM89BD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))		BDBM300098
PNG
(4-{[(1S,2R)-2- cyanocyclopropyl] methoxy}-N-[(2R)-...)
Show SMILES COc1ccnc2[nH]cc(C3CCN(CC3)c3nc(OC[C@H]4C[C@H]4C#N)nc(n3)C(=O)N[C@H](C)CO)c12 |r|
PDB

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 0.0350n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
AXL enzyme inhibition (% inhibition, Kiapp and Ki values) by small molecule inhibitors was evaluated using a fluorescence-based microfluidic mobility...

US Patent US9593097 (2017)


BindingDB Entry DOI: 10.7270/Q2GM89BD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))		BDBM300101
PNG
(4-(benzyloxy)-N- [(2R)-1- hydroxypropan-2- yl]-6-[...)
Show SMILES COc1ccnc2[nH]nc(C3CCN(CC3)c3nc(OCc4ccccc4)nc(n3)C(=O)N[C@H](C)CO)c12 |r|
PDB

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Pfizer Inc.

US Patent


Assay Description
AXL enzyme inhibition (% inhibition, Kiapp and Ki values) by small molecule inhibitors was evaluated using a fluorescence-based microfluidic mobility...

US Patent US9593097 (2017)


BindingDB Entry DOI: 10.7270/Q2GM89BD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))		BDBM300063
PNG
(N-[(2R)-3- hydroxy-3- methylbutan-2-yl]- 4-{[(2R)-...)
Show SMILES COC[C@@H](C)Oc1nc(nc(n1)C(=O)N[C@H](C)C(C)(C)O)N1CCC(CC1)c1c[nH]c2nccc(OC)c12 |r|
PDB

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Pfizer Inc.

US Patent


Assay Description
AXL enzyme inhibition (% inhibition, Kiapp and Ki values) by small molecule inhibitors was evaluated using a fluorescence-based microfluidic mobility...

US Patent US9593097 (2017)


BindingDB Entry DOI: 10.7270/Q2GM89BD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))		BDBM300102
PNG
(4-[(1- cyanocyclopropyl) methoxy]-N-[(2R)- 3-hydro...)
Show SMILES COc1ccnc2[nH]cc(C3CCN(CC3)c3nc(OCC4(CC4)C#N)nc(n3)C(=O)N[C@H](C)C(C)(C)O)c12 |r|
PDB

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UniProtKB/SwissProt

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US Patent
 0.0380n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
AXL enzyme inhibition (% inhibition, Kiapp and Ki values) by small molecule inhibitors was evaluated using a fluorescence-based microfluidic mobility...

US Patent US9593097 (2017)


BindingDB Entry DOI: 10.7270/Q2GM89BD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))		BDBM299849
PNG
(4-[4-({[2-amino-5- (1-methyl-1H- imidazol-4- yl)py...)
Show SMILES Cn1cnc(c1)-c1cnc(N)c(OCC2CCN(CC2)c2nc(OCC3(CC3)C#N)nc(n2)C(=O)NCC(F)(F)F)c1
Show InChI InChI=1S/C26H29F3N10O3/c1-38-10-18(34-15-38)17-8-19(20(31)32-9-17)41-11-16-2-6-39(7-3-16)23-35-21(22(40)33-13-26(27,28)29)36-24(37-23)42-14-25(12-30)4-5-25/h8-10,15-16H,2-7,11,13-14H2,1H3,(H2,31,32)(H,33,40)
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 0.0390n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
AXL enzyme inhibition (% inhibition, Kiapp and Ki values) by small molecule inhibitors was evaluated using a fluorescence-based microfluidic mobility...

US Patent US9593097 (2017)


BindingDB Entry DOI: 10.7270/Q2GM89BD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))		BDBM300061
PNG
(N-(3-amino-3- methylbutan-2-yl)- 2-[(1- cyanocyclo...)
Show SMILES COc1ccnc2[nH]cc(C3CCN(CC3)c3cc(nc(OCC4(CC4)C#N)n3)C(=O)NC(C)C(C)(C)N)c12
PDB

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 0.0400n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
AXL enzyme inhibition (% inhibition, Kiapp and Ki values) by small molecule inhibitors was evaluated using a fluorescence-based microfluidic mobility...

US Patent US9593097 (2017)


BindingDB Entry DOI: 10.7270/Q2GM89BD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))		BDBM299876
PNG
(4-[4-({[2-amino-5- (1-methyl-1H- imidazol-4- yl)py...)
Show SMILES CC(NC(=O)c1nc(OCC2(CC2)C#N)nc(n1)N1CCC(COc2cc(cnc2N)-c2cn(C)cn2)CC1)C(C)(F)F
Show InChI InChI=1S/C28H34F2N10O3/c1-17(27(2,29)30)35-24(41)23-36-25(38-26(37-23)43-15-28(14-31)6-7-28)40-8-4-18(5-9-40)13-42-21-10-19(11-33-22(21)32)20-12-39(3)16-34-20/h10-12,16-18H,4-9,13,15H2,1-3H3,(H2,32,33)(H,35,41)
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Pfizer Inc.

US Patent


Assay Description
AXL enzyme inhibition (% inhibition, Kiapp and Ki values) by small molecule inhibitors was evaluated using a fluorescence-based microfluidic mobility...

US Patent US9593097 (2017)


BindingDB Entry DOI: 10.7270/Q2GM89BD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))		BDBM300065
PNG
((trans)-N-(2- hydroxy- cyclobutyl)- 2-{[(2R)-1- me...)
Show SMILES COC[C@@H](C)Oc1nc(cc(n1)C(=O)NC1CCC1O)N1CCC(CC1)c1n[nH]c2nccc(OC)c12 |r|
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 0.0410n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
AXL enzyme inhibition (% inhibition, Kiapp and Ki values) by small molecule inhibitors was evaluated using a fluorescence-based microfluidic mobility...

US Patent US9593097 (2017)


BindingDB Entry DOI: 10.7270/Q2GM89BD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))		BDBM300107
PNG
(N-[(1R,2S)-2- hydroxycyclobutyl]- 6-[4-(4-methoxy-...)
Show SMILES COc1ccnc2[nH]nc(C3CCN(CC3)c3cc(nc(OC[C@H]4CCCO4)n3)C(=O)N[C@@H]3CC[C@@H]3O)c12 |r|
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Pfizer Inc.

US Patent


Assay Description
AXL enzyme inhibition (% inhibition, Kiapp and Ki values) by small molecule inhibitors was evaluated using a fluorescence-based microfluidic mobility...

US Patent US9593097 (2017)


BindingDB Entry DOI: 10.7270/Q2GM89BD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))		BDBM299851
PNG
(4-[4-({[2-amino-5- (1-methyl-1H- imidazol-4- yl)py...)
Show SMILES CC(C)NC(=O)c1nc(OCC2(CC2)C#N)nc(n1)N1CCC(COc2cc(cnc2N)-c2cn(C)cn2)CC1
Show InChI InChI=1S/C27H34N10O3/c1-17(2)32-24(38)23-33-25(35-26(34-23)40-15-27(14-28)6-7-27)37-8-4-18(5-9-37)13-39-21-10-19(11-30-22(21)29)20-12-36(3)16-31-20/h10-12,16-18H,4-9,13,15H2,1-3H3,(H2,29,30)(H,32,38)
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Pfizer Inc.

US Patent


Assay Description
AXL enzyme inhibition (% inhibition, Kiapp and Ki values) by small molecule inhibitors was evaluated using a fluorescence-based microfluidic mobility...

US Patent US9593097 (2017)


BindingDB Entry DOI: 10.7270/Q2GM89BD
More data for this
Ligand-Target Pair
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