Found 689 hits with Last Name = 'rooney' and Initial = 's' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
D(1A)/D(1B)/D(2)/D(3)/D(4) dopamine receptor
(Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...) | BDBM50366495
((+)butaclamol | CHEMBL1255588)Show SMILES CC(C)(C)[C@@]1(O)CCN2C[C@@H]3c4ccccc4CCc4cccc([C@H]2C1)c34 |r| Show InChI InChI=1S/C25H31NO/c1-24(2,3)25(27)13-14-26-16-21-19-9-5-4-7-17(19)11-12-18-8-6-10-20(23(18)21)22(26)15-25/h4-10,21-22,27H,11-16H2,1-3H3/t21-,22-,25-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet 
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 0.200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Displacement of [3H]- spiperone radioligand binding at the dopamine binding site of rat caudate |
J Med Chem 26: 974-80 (1983)
BindingDB Entry DOI: 10.7270/Q2DR2W2B |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(RAT) | BDBM50120625
(CHEMBL3618330)Show SMILES CNC1CCN(C1)c1ccc(cn1)-n1cnn2cc(cc2c1=O)-c1ccc(Cl)cc1 Show InChI InChI=1S/C22H21ClN6O/c1-24-18-8-9-27(13-18)21-7-6-19(11-25-21)28-14-26-29-12-16(10-20(29)22(28)30)15-2-4-17(23)5-3-15/h2-7,10-12,14,18,24H,8-9,13H2,1H3 | Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 0.300 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description
Displacement of [125I][Phe13,Tyr19]-MCH from rat MCHR1 by scintillation counting analysis |
Bioorg Med Chem Lett 25: 4412-8 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.018
BindingDB Entry DOI: 10.7270/Q2JD4ZMW |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(RAT) | BDBM50241083
(6-(4-chlorophenyl)-3-(3-methoxy-4-(2-(pyrrolidin-1...)Show SMILES COc1cc(ccc1OCCN1CCCC1)-n1cnc2cc(sc2c1=O)-c1ccc(Cl)cc1 Show InChI InChI=1S/C25H24ClN3O3S/c1-31-22-14-19(8-9-21(22)32-13-12-28-10-2-3-11-28)29-16-27-20-15-23(33-24(20)25(29)30)17-4-6-18(26)7-5-17/h4-9,14-16H,2-3,10-13H2,1H3 | Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 0.340 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description
Antagonist activity at rat MCHR1 |
Bioorg Med Chem Lett 25: 2793-9 (2015)
Article DOI: 10.1016/j.bmcl.2015.05.008
BindingDB Entry DOI: 10.7270/Q29C7053 |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(RAT) | BDBM50120624
(CHEMBL3618324)Show SMILES COc1cc(ccc1OCCN1CCCC1)-n1cnn2cc(cc2c1=O)-c1ccc(Cl)cc1 Show InChI InChI=1S/C25H25ClN4O3/c1-32-24-15-21(8-9-23(24)33-13-12-28-10-2-3-11-28)29-17-27-30-16-19(14-22(30)25(29)31)18-4-6-20(26)7-5-18/h4-9,14-17H,2-3,10-13H2,1H3 | Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 0.400 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description
Displacement of [125I][Phe13,Tyr19]-MCH from rat MCHR1 by scintillation counting analysis |
Bioorg Med Chem Lett 25: 4412-8 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.018
BindingDB Entry DOI: 10.7270/Q2JD4ZMW |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50120625
(CHEMBL3618330)Show SMILES CNC1CCN(C1)c1ccc(cn1)-n1cnn2cc(cc2c1=O)-c1ccc(Cl)cc1 Show InChI InChI=1S/C22H21ClN6O/c1-24-18-8-9-27(13-18)21-7-6-19(11-25-21)28-14-26-29-12-16(10-20(29)22(28)30)15-2-4-17(23)5-3-15/h2-7,10-12,14,18,24H,8-9,13H2,1H3 | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 0.400 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description
Displacement of [125I][Phe13,Tyr19]-MCH from human MCHR1 expressed in HEK293 cells by scintillation counting analysis |
Bioorg Med Chem Lett 25: 4412-8 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.018
BindingDB Entry DOI: 10.7270/Q2JD4ZMW |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(RAT) | BDBM50120635
(CHEMBL3618325)Show SMILES COc1cc(ccc1OCCN1CCCC1)-n1cnn2nc(cc2c1=O)-c1ccc(Cl)cc1 Show InChI InChI=1S/C24H24ClN5O3/c1-32-23-14-19(8-9-22(23)33-13-12-28-10-2-3-11-28)29-16-26-30-21(24(29)31)15-20(27-30)17-4-6-18(25)7-5-17/h4-9,14-16H,2-3,10-13H2,1H3 | Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 0.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description
Displacement of [125I][Phe13,Tyr19]-MCH from rat MCHR1 by scintillation counting analysis |
Bioorg Med Chem Lett 25: 4412-8 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.018
BindingDB Entry DOI: 10.7270/Q2JD4ZMW |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50120624
(CHEMBL3618324)Show SMILES COc1cc(ccc1OCCN1CCCC1)-n1cnn2cc(cc2c1=O)-c1ccc(Cl)cc1 Show InChI InChI=1S/C25H25ClN4O3/c1-32-24-15-21(8-9-23(24)33-13-12-28-10-2-3-11-28)29-17-27-30-16-19(14-22(30)25(29)31)18-4-6-20(26)7-5-18/h4-9,14-17H,2-3,10-13H2,1H3 | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 0.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description
Displacement of [125I][Phe13,Tyr19]-MCH from human MCHR1 expressed in HEK293 cells by scintillation counting analysis |
Bioorg Med Chem Lett 25: 4412-8 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.018
BindingDB Entry DOI: 10.7270/Q2JD4ZMW |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50120635
(CHEMBL3618325)Show SMILES COc1cc(ccc1OCCN1CCCC1)-n1cnn2nc(cc2c1=O)-c1ccc(Cl)cc1 Show InChI InChI=1S/C24H24ClN5O3/c1-32-23-14-19(8-9-22(23)33-13-12-28-10-2-3-11-28)29-16-26-30-21(24(29)31)15-20(27-30)17-4-6-18(25)7-5-17/h4-9,14-16H,2-3,10-13H2,1H3 | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 0.700 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description
Displacement of [125I][Phe13,Tyr19]-MCH from human MCHR1 expressed in HEK293 cells by scintillation counting analysis |
Bioorg Med Chem Lett 25: 4412-8 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.018
BindingDB Entry DOI: 10.7270/Q2JD4ZMW |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(RAT) | BDBM50094880
(CHEMBL3589145)Show SMILES CN[C@H]1CCN(C1)c1ccc(cn1)N1Cc2cn(nc2C1=O)-c1ccc(Cl)cc1 |r| Show InChI InChI=1S/C21H21ClN6O/c1-23-16-8-9-26(13-16)19-7-6-18(10-24-19)27-11-14-12-28(25-20(14)21(27)29)17-4-2-15(22)3-5-17/h2-7,10,12,16,23H,8-9,11,13H2,1H3/t16-/m0/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 0.800 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description
Antagonist activity at rat MCHR1 |
Bioorg Med Chem Lett 25: 2793-9 (2015)
Article DOI: 10.1016/j.bmcl.2015.05.008
BindingDB Entry DOI: 10.7270/Q29C7053 |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50120628
(CHEMBL3618334)Show SMILES OC1CN(C1)C1CCN(C1)c1ccc(cn1)-n1cnn2cc(cc2c1=O)-c1ccc(Cl)cc1 Show InChI InChI=1S/C24H23ClN6O2/c25-18-3-1-16(2-4-18)17-9-22-24(33)30(15-27-31(22)11-17)19-5-6-23(26-10-19)28-8-7-20(12-28)29-13-21(32)14-29/h1-6,9-11,15,20-21,32H,7-8,12-14H2 | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 0.800 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description
Displacement of [125I][Phe13,Tyr19]-MCH from human MCHR1 expressed in HEK293 cells by scintillation counting analysis |
Bioorg Med Chem Lett 25: 4412-8 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.018
BindingDB Entry DOI: 10.7270/Q2JD4ZMW |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(RAT) | BDBM50120796
(CHEMBL3618363)Show SMILES COc1cc(ccc1OCC(C)O)-n1cnn2cc(cc2c1=O)-c1ccc(Cl)cc1 Show InChI InChI=1S/C22H20ClN3O4/c1-14(27)12-30-20-8-7-18(10-21(20)29-2)25-13-24-26-11-16(9-19(26)22(25)28)15-3-5-17(23)6-4-15/h3-11,13-14,27H,12H2,1-2H3 | Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 1.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description
Displacement of [125I][Phe13,Tyr19]-MCH from rat MCHR1 by scintillation counting analysis |
Bioorg Med Chem Lett 25: 4412-8 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.018
BindingDB Entry DOI: 10.7270/Q2JD4ZMW |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(RAT) | BDBM50120628
(CHEMBL3618334)Show SMILES OC1CN(C1)C1CCN(C1)c1ccc(cn1)-n1cnn2cc(cc2c1=O)-c1ccc(Cl)cc1 Show InChI InChI=1S/C24H23ClN6O2/c25-18-3-1-16(2-4-18)17-9-22-24(33)30(15-27-31(22)11-17)19-5-6-23(26-10-19)28-8-7-20(12-28)29-13-21(32)14-29/h1-6,9-11,15,20-21,32H,7-8,12-14H2 | Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 1.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description
Displacement of [125I][Phe13,Tyr19]-MCH from rat MCHR1 by scintillation counting analysis |
Bioorg Med Chem Lett 25: 4412-8 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.018
BindingDB Entry DOI: 10.7270/Q2JD4ZMW |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(RAT) | BDBM50120676
(CHEMBL3618340)Show SMILES CCS(=O)(=O)C[C@@H](O)COc1ccc(cc1OC)-n1cnn2cc(cc2c1=O)-c1ccc(Cl)cc1 |r| Show InChI InChI=1S/C24H24ClN3O6S/c1-3-35(31,32)14-20(29)13-34-22-9-8-19(11-23(22)33-2)27-15-26-28-12-17(10-21(28)24(27)30)16-4-6-18(25)7-5-16/h4-12,15,20,29H,3,13-14H2,1-2H3/t20-/m0/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| 1.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description
Displacement of [125I][Phe13,Tyr19]-MCH from rat MCHR1 by scintillation counting analysis |
Bioorg Med Chem Lett 25: 4412-8 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.018
BindingDB Entry DOI: 10.7270/Q2JD4ZMW |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(RAT) | BDBM50120629
(CHEMBL3618336)Show SMILES COc1cc(ccc1OCC(C)(C)O)-n1cnn2cc(cc2c1=O)-c1ccc(Cl)cc1 Show InChI InChI=1S/C23H22ClN3O4/c1-23(2,29)13-31-20-9-8-18(11-21(20)30-3)26-14-25-27-12-16(10-19(27)22(26)28)15-4-6-17(24)7-5-15/h4-12,14,29H,13H2,1-3H3 | Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 1.80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description
Displacement of [125I][Phe13,Tyr19]-MCH from rat MCHR1 by scintillation counting analysis |
Bioorg Med Chem Lett 25: 4412-8 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.018
BindingDB Entry DOI: 10.7270/Q2JD4ZMW |
More data for this
Ligand-Target Pair | |
D(1A)/D(1B)/D(2)/D(3)/D(4) dopamine receptor
(Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...) | BDBM21397
(8-[4-(4-fluorophenyl)-4-keto-butyl]-1-phenyl-1,3,8...)Show SMILES Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)N(CNC2=O)c1ccccc1 Show InChI InChI=1S/C23H26FN3O2/c24-19-10-8-18(9-11-19)21(28)7-4-14-26-15-12-23(13-16-26)22(29)25-17-27(23)20-5-2-1-3-6-20/h1-3,5-6,8-11H,4,7,12-17H2,(H,25,29) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
PDB
UniChem
Patents
Similars
| PubMed
| 2 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Displacement of [3H]- spiperone radioligand binding at the dopamine binding site of rat caudate |
J Med Chem 26: 974-80 (1983)
BindingDB Entry DOI: 10.7270/Q2DR2W2B |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(RAT) | BDBM50120670
(CHEMBL3618338)Show SMILES COc1cc(ccc1N1C[C@H](O)[C@H](O)C1)-n1cnn2cc(cc2c1=O)-c1ccc(Cl)cc1 |r| Show InChI InChI=1S/C23H21ClN4O4/c1-32-22-9-17(6-7-18(22)26-11-20(29)21(30)12-26)27-13-25-28-10-15(8-19(28)23(27)31)14-2-4-16(24)5-3-14/h2-10,13,20-21,29-30H,11-12H2,1H3/t20-,21+ | Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| 2.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description
Displacement of [125I][Phe13,Tyr19]-MCH from rat MCHR1 by scintillation counting analysis |
Bioorg Med Chem Lett 25: 4412-8 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.018
BindingDB Entry DOI: 10.7270/Q2JD4ZMW |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50120629
(CHEMBL3618336)Show SMILES COc1cc(ccc1OCC(C)(C)O)-n1cnn2cc(cc2c1=O)-c1ccc(Cl)cc1 Show InChI InChI=1S/C23H22ClN3O4/c1-23(2,29)13-31-20-9-8-18(11-21(20)30-3)26-14-25-27-12-16(10-19(27)22(26)28)15-4-6-17(24)7-5-15/h4-12,14,29H,13H2,1-3H3 | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 2.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description
Displacement of [125I][Phe13,Tyr19]-MCH from human MCHR1 expressed in HEK293 cells by scintillation counting analysis |
Bioorg Med Chem Lett 25: 4412-8 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.018
BindingDB Entry DOI: 10.7270/Q2JD4ZMW |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50120676
(CHEMBL3618340)Show SMILES CCS(=O)(=O)C[C@@H](O)COc1ccc(cc1OC)-n1cnn2cc(cc2c1=O)-c1ccc(Cl)cc1 |r| Show InChI InChI=1S/C24H24ClN3O6S/c1-3-35(31,32)14-20(29)13-34-22-9-8-19(11-23(22)33-2)27-15-26-28-12-17(10-21(28)24(27)30)16-4-6-18(25)7-5-16/h4-12,15,20,29H,3,13-14H2,1-2H3/t20-/m0/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| 2.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description
Displacement of [125I][Phe13,Tyr19]-MCH from human MCHR1 expressed in HEK293 cells by scintillation counting analysis |
Bioorg Med Chem Lett 25: 4412-8 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.018
BindingDB Entry DOI: 10.7270/Q2JD4ZMW |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(RAT) | BDBM50120634
(CHEMBL3618326)Show SMILES COc1cc(ccc1OCCN1CCCC1)-n1cnn2cc(nc2c1=O)-c1ccc(Cl)cc1 Show InChI InChI=1S/C24H24ClN5O3/c1-32-22-14-19(8-9-21(22)33-13-12-28-10-2-3-11-28)29-16-26-30-15-20(27-23(30)24(29)31)17-4-6-18(25)7-5-17/h4-9,14-16H,2-3,10-13H2,1H3 | Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 2.60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description
Displacement of [125I][Phe13,Tyr19]-MCH from rat MCHR1 by scintillation counting analysis |
Bioorg Med Chem Lett 25: 4412-8 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.018
BindingDB Entry DOI: 10.7270/Q2JD4ZMW |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(RAT) | BDBM50120633
(CHEMBL3618327)Show SMILES COc1cc(ccc1OCC(O)C1CC1)-n1cnn2cc(cc2c1=O)-c1ccc(Cl)cc1 Show InChI InChI=1S/C24H22ClN3O4/c1-31-23-11-19(8-9-22(23)32-13-21(29)16-2-3-16)27-14-26-28-12-17(10-20(28)24(27)30)15-4-6-18(25)7-5-15/h4-12,14,16,21,29H,2-3,13H2,1H3 | Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 2.80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description
Displacement of [125I][Phe13,Tyr19]-MCH from rat MCHR1 by scintillation counting analysis |
Bioorg Med Chem Lett 25: 4412-8 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.018
BindingDB Entry DOI: 10.7270/Q2JD4ZMW |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50120670
(CHEMBL3618338)Show SMILES COc1cc(ccc1N1C[C@H](O)[C@H](O)C1)-n1cnn2cc(cc2c1=O)-c1ccc(Cl)cc1 |r| Show InChI InChI=1S/C23H21ClN4O4/c1-32-22-9-17(6-7-18(22)26-11-20(29)21(30)12-26)27-13-25-28-10-15(8-19(28)23(27)31)14-2-4-16(24)5-3-14/h2-10,13,20-21,29-30H,11-12H2,1H3/t20-,21+ | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| 3.10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description
Displacement of [125I][Phe13,Tyr19]-MCH from human MCHR1 expressed in HEK293 cells by scintillation counting analysis |
Bioorg Med Chem Lett 25: 4412-8 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.018
BindingDB Entry DOI: 10.7270/Q2JD4ZMW |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50120675
(CHEMBL3618339)Show SMILES COc1cc(ccc1OCC1(O)CC(F)(F)C1)-n1cnn2cc(cc2c1=O)-c1ccc(Cl)cc1 Show InChI InChI=1S/C24H20ClF2N3O4/c1-33-21-9-18(6-7-20(21)34-13-23(32)11-24(26,27)12-23)29-14-28-30-10-16(8-19(30)22(29)31)15-2-4-17(25)5-3-15/h2-10,14,32H,11-13H2,1H3 | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 3.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description
Displacement of [125I][Phe13,Tyr19]-MCH from human MCHR1 expressed in HEK293 cells by scintillation counting analysis |
Bioorg Med Chem Lett 25: 4412-8 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.018
BindingDB Entry DOI: 10.7270/Q2JD4ZMW |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50120633
(CHEMBL3618327)Show SMILES COc1cc(ccc1OCC(O)C1CC1)-n1cnn2cc(cc2c1=O)-c1ccc(Cl)cc1 Show InChI InChI=1S/C24H22ClN3O4/c1-31-23-11-19(8-9-22(23)32-13-21(29)16-2-3-16)27-14-26-28-12-17(10-20(28)24(27)30)15-4-6-18(25)7-5-15/h4-12,14,16,21,29H,2-3,13H2,1H3 | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 3.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description
Displacement of [125I][Phe13,Tyr19]-MCH from human MCHR1 expressed in HEK293 cells by scintillation counting analysis |
Bioorg Med Chem Lett 25: 4412-8 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.018
BindingDB Entry DOI: 10.7270/Q2JD4ZMW |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(RAT) | BDBM50094885
(CHEMBL3588863)Show SMILES COc1cc(ccc1OCC(C)(C)OC(=O)CN)N1Cc2cn(nc2C1=O)-c1ccc(Cl)cc1 Show InChI InChI=1S/C24H25ClN4O5/c1-24(2,34-21(30)11-26)14-33-19-9-8-18(10-20(19)32-3)28-12-15-13-29(27-22(15)23(28)31)17-6-4-16(25)5-7-17/h4-10,13H,11-12,14,26H2,1-3H3 | Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 3.80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description
Antagonist activity at rat MCHR1 assessed as 2-(4-chlorophenyl)-5-(4-(2-hydroxy-2-methylpropoxy)-3-methoxyphenyl)-4,5-dihydropyrrolo[3,4-c]pyrazol-6(... |
Bioorg Med Chem Lett 25: 2793-9 (2015)
Article DOI: 10.1016/j.bmcl.2015.05.008
BindingDB Entry DOI: 10.7270/Q29C7053 |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(RAT) | BDBM50120675
(CHEMBL3618339)Show SMILES COc1cc(ccc1OCC1(O)CC(F)(F)C1)-n1cnn2cc(cc2c1=O)-c1ccc(Cl)cc1 Show InChI InChI=1S/C24H20ClF2N3O4/c1-33-21-9-18(6-7-20(21)34-13-23(32)11-24(26,27)12-23)29-14-28-30-10-16(8-19(30)22(29)31)15-2-4-17(25)5-3-15/h2-10,14,32H,11-13H2,1H3 | Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 3.80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description
Displacement of [125I][Phe13,Tyr19]-MCH from rat MCHR1 by scintillation counting analysis |
Bioorg Med Chem Lett 25: 4412-8 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.018
BindingDB Entry DOI: 10.7270/Q2JD4ZMW |
More data for this
Ligand-Target Pair | |
Muscarinic acetylcholine receptor M1/M2/M3/M4/M5
(RAT) | BDBM50017721
(1-Methyl-4-(5H-dibenzo(a,d)cycloheptenylidene)pipe...)Show SMILES [#6]-[#7]-1-[#6]-[#6]\[#6](-[#6]-[#6]-1)=[#6]-1/c2ccccc2-[#6]=[#6]-c2ccccc-12 |c:16| Show InChI InChI=1S/C21H21N/c1-22-14-12-18(13-15-22)21-19-8-4-2-6-16(19)10-11-17-7-3-5-9-20(17)21/h2-11H,12-15H2,1H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| Purchase
CHEMBL
DrugBank
MCE
KEGG
PC cid
PC sid
PDB
UniChem
Patents
Similars
| PubMed
| 4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Displacement of [3H]- QNB binding at the muscarinic-cholinergic binding site of rat brain S1 |
J Med Chem 26: 974-80 (1983)
BindingDB Entry DOI: 10.7270/Q2DR2W2B |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50120634
(CHEMBL3618326)Show SMILES COc1cc(ccc1OCCN1CCCC1)-n1cnn2cc(nc2c1=O)-c1ccc(Cl)cc1 Show InChI InChI=1S/C24H24ClN5O3/c1-32-22-14-19(8-9-21(22)33-13-12-28-10-2-3-11-28)29-16-26-30-15-20(27-23(30)24(29)31)17-4-6-18(25)7-5-17/h4-9,14-16H,2-3,10-13H2,1H3 | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 4.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description
Displacement of [125I][Phe13,Tyr19]-MCH from human MCHR1 expressed in HEK293 cells by scintillation counting analysis |
Bioorg Med Chem Lett 25: 4412-8 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.018
BindingDB Entry DOI: 10.7270/Q2JD4ZMW |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(RAT) | BDBM50120674
(CHEMBL3618337)Show SMILES COc1cc(ccc1N1CC[C@@H](O)C1)-n1cnn2cc(cc2c1=O)-c1ccc(Cl)cc1 |r| Show InChI InChI=1S/C23H21ClN4O3/c1-31-22-11-18(6-7-20(22)26-9-8-19(29)13-26)27-14-25-28-12-16(10-21(28)23(27)30)15-2-4-17(24)5-3-15/h2-7,10-12,14,19,29H,8-9,13H2,1H3/t19-/m1/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 4.70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description
Displacement of [125I][Phe13,Tyr19]-MCH from rat MCHR1 by scintillation counting analysis |
Bioorg Med Chem Lett 25: 4412-8 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.018
BindingDB Entry DOI: 10.7270/Q2JD4ZMW |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50120674
(CHEMBL3618337)Show SMILES COc1cc(ccc1N1CC[C@@H](O)C1)-n1cnn2cc(cc2c1=O)-c1ccc(Cl)cc1 |r| Show InChI InChI=1S/C23H21ClN4O3/c1-31-22-11-18(6-7-20(22)26-9-8-19(29)13-26)27-14-25-28-12-16(10-21(28)23(27)30)15-2-4-17(24)5-3-15/h2-7,10-12,14,19,29H,8-9,13H2,1H3/t19-/m1/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 4.80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description
Displacement of [125I][Phe13,Tyr19]-MCH from human MCHR1 expressed in HEK293 cells by scintillation counting analysis |
Bioorg Med Chem Lett 25: 4412-8 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.018
BindingDB Entry DOI: 10.7270/Q2JD4ZMW |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50120630
(CHEMBL3618332)Show SMILES O[C@@H]1CCN(C1)c1ccc(cn1)-n1cnn2cc(cc2c1=O)-c1ccc(Cl)cc1 |r| Show InChI InChI=1S/C21H18ClN5O2/c22-16-3-1-14(2-4-16)15-9-19-21(29)26(13-24-27(19)11-15)17-5-6-20(23-10-17)25-8-7-18(28)12-25/h1-6,9-11,13,18,28H,7-8,12H2/t18-/m1/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 5.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description
Displacement of [125I][Phe13,Tyr19]-MCH from human MCHR1 expressed in HEK293 cells by scintillation counting analysis |
Bioorg Med Chem Lett 25: 4412-8 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.018
BindingDB Entry DOI: 10.7270/Q2JD4ZMW |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(RAT) | BDBM50120630
(CHEMBL3618332)Show SMILES O[C@@H]1CCN(C1)c1ccc(cn1)-n1cnn2cc(cc2c1=O)-c1ccc(Cl)cc1 |r| Show InChI InChI=1S/C21H18ClN5O2/c22-16-3-1-14(2-4-16)15-9-19-21(29)26(13-24-27(19)11-15)17-5-6-20(23-10-17)25-8-7-18(28)12-25/h1-6,9-11,13,18,28H,7-8,12H2/t18-/m1/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 5.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description
Displacement of [125I][Phe13,Tyr19]-MCH from rat MCHR1 by scintillation counting analysis |
Bioorg Med Chem Lett 25: 4412-8 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.018
BindingDB Entry DOI: 10.7270/Q2JD4ZMW |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50120729
(CHEMBL3618345)Show SMILES COc1cc(ccc1OCC1(O)CC(F)(F)C1)-n1cnn2cc(cc2c1=O)-c1ccc(Cl)cn1 Show InChI InChI=1S/C23H19ClF2N4O4/c1-33-20-7-16(3-5-19(20)34-12-22(32)10-23(25,26)11-22)29-13-28-30-9-14(6-18(30)21(29)31)17-4-2-15(24)8-27-17/h2-9,13,32H,10-12H2,1H3 | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 6.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description
Displacement of [125I][Phe13,Tyr19]-MCH from human MCHR1 expressed in HEK293 cells by scintillation counting analysis |
Bioorg Med Chem Lett 25: 4412-8 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.018
BindingDB Entry DOI: 10.7270/Q2JD4ZMW |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50120678
(CHEMBL3618342)Show SMILES COc1cc(ccc1OC[C@H](O)C1CC1)-n1cnn2cc(cc2c1=O)-c1ccc(Cl)cn1 |r| Show InChI InChI=1S/C23H21ClN4O4/c1-31-22-9-17(5-7-21(22)32-12-20(29)14-2-3-14)27-13-26-28-11-15(8-19(28)23(27)30)18-6-4-16(24)10-25-18/h4-11,13-14,20,29H,2-3,12H2,1H3/t20-/m0/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 6.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description
Displacement of [125I][Phe13,Tyr19]-MCH from human MCHR1 expressed in HEK293 cells by scintillation counting analysis |
Bioorg Med Chem Lett 25: 4412-8 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.018
BindingDB Entry DOI: 10.7270/Q2JD4ZMW |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(RAT) | BDBM50120729
(CHEMBL3618345)Show SMILES COc1cc(ccc1OCC1(O)CC(F)(F)C1)-n1cnn2cc(cc2c1=O)-c1ccc(Cl)cn1 Show InChI InChI=1S/C23H19ClF2N4O4/c1-33-20-7-16(3-5-19(20)34-12-22(32)10-23(25,26)11-22)29-13-28-30-9-14(6-18(30)21(29)31)17-4-2-15(24)8-27-17/h2-9,13,32H,10-12H2,1H3 | Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 6.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description
Displacement of [125I][Phe13,Tyr19]-MCH from rat MCHR1 by scintillation counting analysis |
Bioorg Med Chem Lett 25: 4412-8 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.018
BindingDB Entry DOI: 10.7270/Q2JD4ZMW |
More data for this
Ligand-Target Pair | |
D(1A)/D(1B)/D(2)/D(3)/D(4) dopamine receptor
(Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...) | BDBM50026964
(9-Bromo-11-(1-methyl-piperidin-4-ylidene)-11H-benz...)Show SMILES [#6]-[#7]-1-[#6]-[#6]\[#6](-[#6]-[#6]-1)=[#6]-1/c2cccn2-[#6]=[#6]-c2ccc(Br)cc-12 |c:15| Show InChI InChI=1S/C19H19BrN2/c1-21-10-6-15(7-11-21)19-17-13-16(20)5-4-14(17)8-12-22-9-2-3-18(19)22/h2-5,8-9,12-13H,6-7,10-11H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| 6.60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Displacement of [3H]- apomorphine radioligand binding at the dopamine binding site of rat caudate |
J Med Chem 26: 974-80 (1983)
BindingDB Entry DOI: 10.7270/Q2DR2W2B |
More data for this
Ligand-Target Pair | |
D(1A)/D(1B)/D(2)/D(3)/D(4) dopamine receptor
(Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...) | BDBM50026968
(9-Chloro-11-(1-methyl-piperidin-4-ylidene)-11H-ben...)Show SMILES [#6]-[#7]-1-[#6]-[#6]\[#6](-[#6]-[#6]-1)=[#6]-1/c2cccn2-[#6]=[#6]-c2ccc(Cl)cc-12 |c:15| Show InChI InChI=1S/C19H19ClN2/c1-21-10-6-15(7-11-21)19-17-13-16(20)5-4-14(17)8-12-22-9-2-3-18(19)22/h2-5,8-9,12-13H,6-7,10-11H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 6.80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Displacement of [3H]- apomorphine radioligand binding at the dopamine binding site of rat caudate |
J Med Chem 26: 974-80 (1983)
BindingDB Entry DOI: 10.7270/Q2DR2W2B |
More data for this
Ligand-Target Pair | |
D(1A)/D(1B)/D(2)/D(3)/D(4) dopamine receptor
(Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...) | BDBM50026964
(9-Bromo-11-(1-methyl-piperidin-4-ylidene)-11H-benz...)Show SMILES [#6]-[#7]-1-[#6]-[#6]\[#6](-[#6]-[#6]-1)=[#6]-1/c2cccn2-[#6]=[#6]-c2ccc(Br)cc-12 |c:15| Show InChI InChI=1S/C19H19BrN2/c1-21-10-6-15(7-11-21)19-17-13-16(20)5-4-14(17)8-12-22-9-2-3-18(19)22/h2-5,8-9,12-13H,6-7,10-11H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| 7 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Displacement of [3H]- spiperone radioligand binding at the dopamine binding site of rat caudate |
J Med Chem 26: 974-80 (1983)
BindingDB Entry DOI: 10.7270/Q2DR2W2B |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(RAT) | BDBM50094881
(CHEMBL3589155)Show SMILES COc1cc(ccc1OCC(C)(C)OC(=O)CN)-n1cnc2cc(sc2c1=O)-c1ccc(Cl)cc1 Show InChI InChI=1S/C25H24ClN3O5S/c1-25(2,34-22(30)12-27)13-33-19-9-8-17(10-20(19)32-3)29-14-28-18-11-21(35-23(18)24(29)31)15-4-6-16(26)7-5-15/h4-11,14H,12-13,27H2,1-3H3 | Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 7.20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description
Antagonist activity at rat MCHR1 assessed as 6-(4-chlorophenyl)-3-(4-(2-hydroxy-2-methylpropoxy)-3-methoxyphenyl)thieno[3,2-d]pyrimidin-4(3H)-one |
Bioorg Med Chem Lett 25: 2793-9 (2015)
Article DOI: 10.1016/j.bmcl.2015.05.008
BindingDB Entry DOI: 10.7270/Q29C7053 |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(RAT) | BDBM50094884
(CHEMBL3589154)Show SMILES COc1cc(ccc1OCC(C)(C)O)-n1cnc2cc(sc2c1=O)-c1ccc(Cl)cc1 Show InChI InChI=1S/C23H21ClN2O4S/c1-23(2,28)12-30-18-9-8-16(10-19(18)29-3)26-13-25-17-11-20(31-21(17)22(26)27)14-4-6-15(24)7-5-14/h4-11,13,28H,12H2,1-3H3 | Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 7.20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description
Displacement of [125I][Phe13,Tyr19]-MCH from rat MCHR1 by scintillation counting analysis |
Bioorg Med Chem Lett 25: 4412-8 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.018
BindingDB Entry DOI: 10.7270/Q2JD4ZMW |
More data for this
Ligand-Target Pair | |
D(1A)/D(1B)/D(2)/D(3)/D(4) dopamine receptor
(Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...) | BDBM50026974
(9-Bromo-11-(1-methyl-piperidin-4-ylidene)-6,11-dih...)Show SMILES [#6]-[#7]-1-[#6]-[#6]\[#6](-[#6]-[#6]-1)=[#6]-1/c2cccn2-[#6]-[#6]-c2ccc(Br)cc-12 Show InChI InChI=1S/C19H21BrN2/c1-21-10-6-15(7-11-21)19-17-13-16(20)5-4-14(17)8-12-22-9-2-3-18(19)22/h2-5,9,13H,6-8,10-12H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 7.20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Displacement of [3H]- apomorphine radioligand binding at the dopamine binding site of rat caudate |
J Med Chem 26: 974-80 (1983)
BindingDB Entry DOI: 10.7270/Q2DR2W2B |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 1A/1B/1D/1F
(RAT-Rattus norvegicus (rat)-Rattus norvegicus (Rat...) | BDBM50026968
(9-Chloro-11-(1-methyl-piperidin-4-ylidene)-11H-ben...)Show SMILES [#6]-[#7]-1-[#6]-[#6]\[#6](-[#6]-[#6]-1)=[#6]-1/c2cccn2-[#6]=[#6]-c2ccc(Cl)cc-12 |c:15| Show InChI InChI=1S/C19H19ClN2/c1-21-10-6-15(7-11-21)19-17-13-16(20)5-4-14(17)8-12-22-9-2-3-18(19)22/h2-5,8-9,12-13H,6-7,10-11H2,1H3 | PDB
MMDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 7.60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Displacement of [3H]LSD radioligand binding at the serotonin-1 binding site of rat cortex |
J Med Chem 26: 974-80 (1983)
BindingDB Entry DOI: 10.7270/Q2DR2W2B |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 1A/1B/1D/1F
(RAT-Rattus norvegicus (rat)-Rattus norvegicus (Rat...) | BDBM50026974
(9-Bromo-11-(1-methyl-piperidin-4-ylidene)-6,11-dih...)Show SMILES [#6]-[#7]-1-[#6]-[#6]\[#6](-[#6]-[#6]-1)=[#6]-1/c2cccn2-[#6]-[#6]-c2ccc(Br)cc-12 Show InChI InChI=1S/C19H21BrN2/c1-21-10-6-15(7-11-21)19-17-13-16(20)5-4-14(17)8-12-22-9-2-3-18(19)22/h2-5,9,13H,6-8,10-12H2,1H3 | PDB
MMDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 7.80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Displacement of [3H]LSD radioligand binding at the serotonin-1 binding site of rat cortex |
J Med Chem 26: 974-80 (1983)
BindingDB Entry DOI: 10.7270/Q2DR2W2B |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(RAT) | BDBM50120787
(CHEMBL3618348)Show SMILES COc1cc(ccc1OCC1(O)CC(F)(F)C1)-n1cnn2cc(cc2c1=O)-c1ncc(Cl)cn1 Show InChI InChI=1S/C22H18ClF2N5O4/c1-33-18-5-15(2-3-17(18)34-11-21(32)9-22(24,25)10-21)29-12-28-30-8-13(4-16(30)20(29)31)19-26-6-14(23)7-27-19/h2-8,12,32H,9-11H2,1H3 | Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 7.90 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description
Displacement of [125I][Phe13,Tyr19]-MCH from rat MCHR1 by scintillation counting analysis |
Bioorg Med Chem Lett 25: 4412-8 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.018
BindingDB Entry DOI: 10.7270/Q2JD4ZMW |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(RAT) | BDBM50120673
(CHEMBL3618321)Show SMILES COc1ccc(cc1OC)-n1cnn2cc(cc2c1=O)-c1ccc(Cl)cc1 Show InChI InChI=1S/C20H16ClN3O3/c1-26-18-8-7-16(10-19(18)27-2)23-12-22-24-11-14(9-17(24)20(23)25)13-3-5-15(21)6-4-13/h3-12H,1-2H3 | Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 8 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description
Displacement of [125I][Phe13,Tyr19]-MCH from rat MCHR1 by scintillation counting analysis |
Bioorg Med Chem Lett 25: 4412-8 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.018
BindingDB Entry DOI: 10.7270/Q2JD4ZMW |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 1A/1B/1D/1F
(RAT-Rattus norvegicus (rat)-Rattus norvegicus (Rat...) | BDBM50026970
(9-Chloro-11-(1-methyl-piperidin-4-ylidene)-6,11-di...)Show SMILES [#6]-[#7]-1-[#6]-[#6]\[#6](-[#6]-[#6]-1)=[#6]-1/c2cccn2-[#6]-[#6]-c2ccc(Cl)cc-12 Show InChI InChI=1S/C19H21ClN2/c1-21-10-6-15(7-11-21)19-17-13-16(20)5-4-14(17)8-12-22-9-2-3-18(19)22/h2-5,9,13H,6-8,10-12H2,1H3 | PDB
MMDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 8.20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Displacement of [3H]LSD radioligand binding at the serotonin-1 binding site of rat cortex |
J Med Chem 26: 974-80 (1983)
BindingDB Entry DOI: 10.7270/Q2DR2W2B |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(RAT) | BDBM50120716
(CHEMBL3618344)Show SMILES CCS(=O)(=O)C[C@@H](O)COc1ccc(cc1OC)-n1cnn2cc(cc2c1=O)-c1ccc(Cl)cn1 |r| Show InChI InChI=1S/C23H23ClN4O6S/c1-3-35(31,32)13-18(29)12-34-21-7-5-17(9-22(21)33-2)27-14-26-28-11-15(8-20(28)23(27)30)19-6-4-16(24)10-25-19/h4-11,14,18,29H,3,12-13H2,1-2H3/t18-/m0/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 8.70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description
Displacement of [125I][Phe13,Tyr19]-MCH from rat MCHR1 by scintillation counting analysis |
Bioorg Med Chem Lett 25: 4412-8 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.018
BindingDB Entry DOI: 10.7270/Q2JD4ZMW |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 1A/1B/1D/1F
(RAT-Rattus norvegicus (rat)-Rattus norvegicus (Rat...) | BDBM50026964
(9-Bromo-11-(1-methyl-piperidin-4-ylidene)-11H-benz...)Show SMILES [#6]-[#7]-1-[#6]-[#6]\[#6](-[#6]-[#6]-1)=[#6]-1/c2cccn2-[#6]=[#6]-c2ccc(Br)cc-12 |c:15| Show InChI InChI=1S/C19H19BrN2/c1-21-10-6-15(7-11-21)19-17-13-16(20)5-4-14(17)8-12-22-9-2-3-18(19)22/h2-5,8-9,12-13H,6-7,10-11H2,1H3 | PDB
MMDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| 8.70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Displacement of [3H]LSD radioligand binding at the serotonin-1 binding site of rat cortex |
J Med Chem 26: 974-80 (1983)
BindingDB Entry DOI: 10.7270/Q2DR2W2B |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50120787
(CHEMBL3618348)Show SMILES COc1cc(ccc1OCC1(O)CC(F)(F)C1)-n1cnn2cc(cc2c1=O)-c1ncc(Cl)cn1 Show InChI InChI=1S/C22H18ClF2N5O4/c1-33-18-5-15(2-3-17(18)34-11-21(32)9-22(24,25)10-21)29-12-28-30-8-13(4-16(30)20(29)31)19-26-6-14(23)7-27-19/h2-8,12,32H,9-11H2,1H3 | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 9 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description
Displacement of [125I][Phe13,Tyr19]-MCH from human MCHR1 expressed in HEK293 cells by scintillation counting analysis |
Bioorg Med Chem Lett 25: 4412-8 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.018
BindingDB Entry DOI: 10.7270/Q2JD4ZMW |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50120708
(CHEMBL3618343)Show SMILES COc1cc(ccc1N1CC[C@@H](O)C1)-n1cnn2cc(cc2c1=O)-c1ccc(Cl)cn1 |r| Show InChI InChI=1S/C22H20ClN5O3/c1-31-21-9-16(3-5-19(21)26-7-6-17(29)12-26)27-13-25-28-11-14(8-20(28)22(27)30)18-4-2-15(23)10-24-18/h2-5,8-11,13,17,29H,6-7,12H2,1H3/t17-/m1/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 9.10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description
Displacement of [125I][Phe13,Tyr19]-MCH from human MCHR1 expressed in HEK293 cells by scintillation counting analysis |
Bioorg Med Chem Lett 25: 4412-8 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.018
BindingDB Entry DOI: 10.7270/Q2JD4ZMW |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(RAT) | BDBM50120708
(CHEMBL3618343)Show SMILES COc1cc(ccc1N1CC[C@@H](O)C1)-n1cnn2cc(cc2c1=O)-c1ccc(Cl)cn1 |r| Show InChI InChI=1S/C22H20ClN5O3/c1-31-21-9-16(3-5-19(21)26-7-6-17(29)12-26)27-13-25-28-11-14(8-20(28)22(27)30)18-4-2-15(23)10-24-18/h2-5,8-11,13,17,29H,6-7,12H2,1H3/t17-/m1/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 9.60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description
Displacement of [125I][Phe13,Tyr19]-MCH from rat MCHR1 by scintillation counting analysis |
Bioorg Med Chem Lett 25: 4412-8 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.018
BindingDB Entry DOI: 10.7270/Q2JD4ZMW |
More data for this
Ligand-Target Pair | |
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