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Compile Data Set for Download or QSAR

Found 287 hits with Last Name = 'rosi' and Initial = 'f'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
5-hydroxytryptamine receptor 4


(Homo sapiens (Human))		BDBM50398985
PNG
(CHEMBL2177130)
Show SMILES CC(C)n1nc(C(=O)NCC2CCN(CCc3ccccc3)CC2)c2ccccc12
Show InChI InChI=1S/C25H32N4O/c1-19(2)29-23-11-7-6-10-22(23)24(27-29)25(30)26-18-21-13-16-28(17-14-21)15-12-20-8-4-3-5-9-20/h3-11,19,21H,12-18H2,1-2H3,(H,26,30)
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 0.0794n/an/an/an/an/an/an/an/a



Angelini Santa Palomba Research Center

Curated by ChEMBL


Assay Description
Displacement of [3H](1-(2-(methylsulfonamido)ethyl)piperidin-4-yl)methyl 1-methyl-1H-indole-3-carboxylate from human 5HT4R expressed in HEK293 cells

J Med Chem 55: 9446-66 (2012)


Article DOI: 10.1021/jm300573d
BindingDB Entry DOI: 10.7270/Q27082JT
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 4


(Homo sapiens (Human))		BDBM50398983
PNG
(CHEMBL2179697)
Show SMILES CC(C)n1nc(C(=O)NCC2CCN(CCc3ccccn3)CC2)c2ccccc12
Show InChI InChI=1S/C24H31N5O/c1-18(2)29-22-9-4-3-8-21(22)23(27-29)24(30)26-17-19-10-14-28(15-11-19)16-12-20-7-5-6-13-25-20/h3-9,13,18-19H,10-12,14-17H2,1-2H3,(H,26,30)
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 0.100n/an/an/an/an/an/an/an/a



Angelini Santa Palomba Research Center

Curated by ChEMBL


Assay Description
Displacement of [3H](1-(2-(methylsulfonamido)ethyl)piperidin-4-yl)methyl 1-methyl-1H-indole-3-carboxylate from human 5HT4R expressed in HEK293 cells

J Med Chem 55: 9446-66 (2012)


Article DOI: 10.1021/jm300573d
BindingDB Entry DOI: 10.7270/Q27082JT
More data for this
Ligand-Target Pair
Procathepsin L


(Homo sapiens (Human))		BDBM50451631
PNG
(CHEMBL4212454)
Show SMILES CN(C#N)N(C)C(=O)[C@H](Cc1ccccc1)NC(=O)c1cc(nn1C)C(C)(C)C |r|
Show InChI InChI=1S/C21H28N6O2/c1-21(2,3)18-13-17(26(5)24-18)19(28)23-16(12-15-10-8-7-9-11-15)20(29)27(6)25(4)14-22/h7-11,13,16H,12H2,1-6H3,(H,23,28)/t16-/m0/s1
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 0.126n/an/an/an/an/an/an/an/a


TBA

Assay Description
Inhibition of human cathepsin L using Z-Phe-Arg-7-amido-4-methylcoumarin as substrate preincubated for 2 mins followed by substrate addition by fluor...

Citation and Details

Article DOI: 10.1016/j.bmc.2020.115743
BindingDB Entry DOI: 10.7270/Q27H1P7R
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 4


(Homo sapiens (Human))		BDBM85026
PNG
(N-(1-Butylpiperidine-4-ylmethyl)-1,2-(trimethylene...)
Show SMILES CCCCN1CCC(CNC(=O)c2c3OCCCn3c3ccccc23)CC1
Show InChI InChI=1S/C22H31N3O2/c1-2-3-11-24-13-9-17(10-14-24)16-23-21(26)20-18-7-4-5-8-19(18)25-12-6-15-27-22(20)25/h4-5,7-8,17H,2-3,6,9-16H2,1H3,(H,23,26)
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 0.158n/an/an/an/an/an/an/an/a



Angelini Santa Palomba Research Center

Curated by ChEMBL


Assay Description
Displacement of [3H](1-(2-(methylsulfonamido)ethyl)piperidin-4-yl)methyl 1-methyl-1H-indole-3-carboxylate from human 5HT4R expressed in HEK293 cells

J Med Chem 55: 9446-66 (2012)


Article DOI: 10.1021/jm300573d
BindingDB Entry DOI: 10.7270/Q27082JT
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 4


(Homo sapiens (Human))		BDBM50398981
PNG
(CHEMBL2179699)
Show SMILES CC(C)n1nc(C(=O)NCC2CCN(CCC3CCCCC3)CC2)c2ccccc12
Show InChI InChI=1S/C25H38N4O/c1-19(2)29-23-11-7-6-10-22(23)24(27-29)25(30)26-18-21-13-16-28(17-14-21)15-12-20-8-4-3-5-9-20/h6-7,10-11,19-21H,3-5,8-9,12-18H2,1-2H3,(H,26,30)
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 0.158n/an/an/an/an/an/an/an/a



Angelini Santa Palomba Research Center

Curated by ChEMBL


Assay Description
Displacement of [3H](1-(2-(methylsulfonamido)ethyl)piperidin-4-yl)methyl 1-methyl-1H-indole-3-carboxylate from human 5HT4R expressed in HEK293 cells

J Med Chem 55: 9446-66 (2012)


Article DOI: 10.1021/jm300573d
BindingDB Entry DOI: 10.7270/Q27082JT
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 4


(Homo sapiens (Human))		BDBM50398975
PNG
(CHEMBL2179706)
Show SMILES CC(C)n1nc(C(=O)NCC2CCN(CCc3ccc(N)cc3)CC2)c2ccccc12
Show InChI InChI=1S/C25H33N5O/c1-18(2)30-23-6-4-3-5-22(23)24(28-30)25(31)27-17-20-12-15-29(16-13-20)14-11-19-7-9-21(26)10-8-19/h3-10,18,20H,11-17,26H2,1-2H3,(H,27,31)
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 0.200n/an/an/an/an/an/an/an/a



Angelini Santa Palomba Research Center

Curated by ChEMBL


Assay Description
Displacement of [3H](1-(2-(methylsulfonamido)ethyl)piperidin-4-yl)methyl 1-methyl-1H-indole-3-carboxylate from human 5HT4R expressed in HEK293 cells

J Med Chem 55: 9446-66 (2012)


Article DOI: 10.1021/jm300573d
BindingDB Entry DOI: 10.7270/Q27082JT
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 4


(Homo sapiens (Human))		BDBM50398978
PNG
(CHEMBL2179704)
Show SMILES CC(C)n1nc(C(=O)NCC2CCN(CCc3ccc(O)cc3)CC2)c2ccccc12
Show InChI InChI=1S/C25H32N4O2/c1-18(2)29-23-6-4-3-5-22(23)24(27-29)25(31)26-17-20-12-15-28(16-13-20)14-11-19-7-9-21(30)10-8-19/h3-10,18,20,30H,11-17H2,1-2H3,(H,26,31)
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 0.251n/an/an/an/an/an/an/an/a



Angelini Santa Palomba Research Center

Curated by ChEMBL


Assay Description
Displacement of [3H](1-(2-(methylsulfonamido)ethyl)piperidin-4-yl)methyl 1-methyl-1H-indole-3-carboxylate from human 5HT4R expressed in HEK293 cells

J Med Chem 55: 9446-66 (2012)


Article DOI: 10.1021/jm300573d
BindingDB Entry DOI: 10.7270/Q27082JT
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 4


(Homo sapiens (Human))		BDBM50398976
PNG
(CHEMBL2179702)
Show SMILES CC(C)n1nc(C(=O)NCC2CCN(CCNS(C)(=O)=O)CC2)c2ccccc12
Show InChI InChI=1S/C20H31N5O3S/c1-15(2)25-18-7-5-4-6-17(18)19(23-25)20(26)21-14-16-8-11-24(12-9-16)13-10-22-29(3,27)28/h4-7,15-16,22H,8-14H2,1-3H3,(H,21,26)
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 0.316n/an/an/an/an/an/an/an/a



Angelini Santa Palomba Research Center

Curated by ChEMBL


Assay Description
Displacement of [3H](1-(2-(methylsulfonamido)ethyl)piperidin-4-yl)methyl 1-methyl-1H-indole-3-carboxylate from human 5HT4R expressed in HEK293 cells

J Med Chem 55: 9446-66 (2012)


Article DOI: 10.1021/jm300573d
BindingDB Entry DOI: 10.7270/Q27082JT
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 4


(Homo sapiens (Human))		BDBM50398980
PNG
(CHEMBL2179700)
Show SMILES CC(C)n1nc(C(=O)NCC2CCN(CCN3CCOCC3)CC2)c2ccccc12
Show InChI InChI=1S/C23H35N5O2/c1-18(2)28-21-6-4-3-5-20(21)22(25-28)23(29)24-17-19-7-9-26(10-8-19)11-12-27-13-15-30-16-14-27/h3-6,18-19H,7-17H2,1-2H3,(H,24,29)
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 0.398n/an/an/an/an/an/an/an/a



Angelini Santa Palomba Research Center

Curated by ChEMBL


Assay Description
Displacement of [3H](1-(2-(methylsulfonamido)ethyl)piperidin-4-yl)methyl 1-methyl-1H-indole-3-carboxylate from human 5HT4R expressed in HEK293 cells

J Med Chem 55: 9446-66 (2012)


Article DOI: 10.1021/jm300573d
BindingDB Entry DOI: 10.7270/Q27082JT
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 4


(Homo sapiens (Human))		BDBM50398986
PNG
(CHEMBL2179703)
Show SMILES CNC(=O)CCN1CCC(CNC(=O)c2nn(C(C)C)c3ccccc23)CC1
Show InChI InChI=1S/C21H31N5O2/c1-15(2)26-18-7-5-4-6-17(18)20(24-26)21(28)23-14-16-8-11-25(12-9-16)13-10-19(27)22-3/h4-7,15-16H,8-14H2,1-3H3,(H,22,27)(H,23,28)
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 0.501n/an/an/an/an/an/an/an/a



Angelini Santa Palomba Research Center

Curated by ChEMBL


Assay Description
Displacement of [3H](1-(2-(methylsulfonamido)ethyl)piperidin-4-yl)methyl 1-methyl-1H-indole-3-carboxylate from human 5HT4R expressed in HEK293 cells

J Med Chem 55: 9446-66 (2012)


Article DOI: 10.1021/jm300573d
BindingDB Entry DOI: 10.7270/Q27082JT
More data for this
Ligand-Target Pair
Procathepsin L


(Homo sapiens (Human))		BDBM50451625
PNG
(CHEMBL4217414)
Show SMILES CC(C)C[C@H](NC(=O)c1cc(nn1C)C(C)(C)C)C(=O)N(C)N(C)C#N |r|
Show InChI InChI=1S/C18H30N6O2/c1-12(2)9-13(17(26)24(8)22(6)11-19)20-16(25)14-10-15(18(3,4)5)21-23(14)7/h10,12-13H,9H2,1-8H3,(H,20,25)/t13-/m0/s1
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 0.501n/an/an/an/an/an/an/an/a


TBA

Assay Description
Inhibition of human cathepsin L using Z-Phe-Arg-7-amido-4-methylcoumarin as substrate preincubated for 2 mins followed by substrate addition by fluor...

Citation and Details

Article DOI: 10.1016/j.bmc.2020.115743
BindingDB Entry DOI: 10.7270/Q27H1P7R
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 4


(Homo sapiens (Human))		BDBM50398984
PNG
(CHEMBL2179696)
Show SMILES CC(C)n1nc(C(=O)NCC2CCN(Cc3ccccc3)CC2)c2ccccc12
Show InChI InChI=1S/C24H30N4O/c1-18(2)28-22-11-7-6-10-21(22)23(26-28)24(29)25-16-19-12-14-27(15-13-19)17-20-8-4-3-5-9-20/h3-11,18-19H,12-17H2,1-2H3,(H,25,29)
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 0.631n/an/an/an/an/an/an/an/a



Angelini Santa Palomba Research Center

Curated by ChEMBL


Assay Description
Displacement of [3H](1-(2-(methylsulfonamido)ethyl)piperidin-4-yl)methyl 1-methyl-1H-indole-3-carboxylate from human 5HT4R expressed in HEK293 cells

J Med Chem 55: 9446-66 (2012)


Article DOI: 10.1021/jm300573d
BindingDB Entry DOI: 10.7270/Q27082JT
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 4


(Homo sapiens (Human))		BDBM50398964
PNG
(CHEMBL2179707)
Show SMILES CC(C)n1nc(C(=O)NCC2CCN(CCc3ccc(cc3)C(O)=O)CC2)c2ccccc12
Show InChI InChI=1S/C26H32N4O3/c1-18(2)30-23-6-4-3-5-22(23)24(28-30)25(31)27-17-20-12-15-29(16-13-20)14-11-19-7-9-21(10-8-19)26(32)33/h3-10,18,20H,11-17H2,1-2H3,(H,27,31)(H,32,33)
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 0.794n/an/an/an/an/an/an/an/a



Angelini Santa Palomba Research Center

Curated by ChEMBL


Assay Description
Displacement of [3H](1-(2-(methylsulfonamido)ethyl)piperidin-4-yl)methyl 1-methyl-1H-indole-3-carboxylate from human 5HT4R expressed in HEK293 cells

J Med Chem 55: 9446-66 (2012)


Article DOI: 10.1021/jm300573d
BindingDB Entry DOI: 10.7270/Q27082JT
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 4


(Homo sapiens (Human))		BDBM50398979
PNG
(CHEMBL2179701)
Show SMILES CC(C)n1nc(C(=O)NCC2CCN(CCCN(C)C)CC2)c2ccccc12
Show InChI InChI=1S/C22H35N5O/c1-17(2)27-20-9-6-5-8-19(20)21(24-27)22(28)23-16-18-10-14-26(15-11-18)13-7-12-25(3)4/h5-6,8-9,17-18H,7,10-16H2,1-4H3,(H,23,28)
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 0.794n/an/an/an/an/an/an/an/a



Angelini Santa Palomba Research Center

Curated by ChEMBL


Assay Description
Displacement of [3H](1-(2-(methylsulfonamido)ethyl)piperidin-4-yl)methyl 1-methyl-1H-indole-3-carboxylate from human 5HT4R expressed in HEK293 cells

J Med Chem 55: 9446-66 (2012)


Article DOI: 10.1021/jm300573d
BindingDB Entry DOI: 10.7270/Q27082JT
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 4


(Homo sapiens (Human))		BDBM50398977
PNG
(CHEMBL2179705)
Show SMILES CC(C)n1nc(C(=O)NCC2CCN(CCc3ccc(cc3)[N+]([O-])=O)CC2)c2ccccc12
Show InChI InChI=1S/C25H31N5O3/c1-18(2)29-23-6-4-3-5-22(23)24(27-29)25(31)26-17-20-12-15-28(16-13-20)14-11-19-7-9-21(10-8-19)30(32)33/h3-10,18,20H,11-17H2,1-2H3,(H,26,31)
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 1.26n/an/an/an/an/an/an/an/a



Angelini Santa Palomba Research Center

Curated by ChEMBL


Assay Description
Displacement of [3H](1-(2-(methylsulfonamido)ethyl)piperidin-4-yl)methyl 1-methyl-1H-indole-3-carboxylate from human 5HT4R expressed in HEK293 cells

J Med Chem 55: 9446-66 (2012)


Article DOI: 10.1021/jm300573d
BindingDB Entry DOI: 10.7270/Q27082JT
More data for this
Ligand-Target Pair
Procathepsin L


(Homo sapiens (Human))		BDBM31992
PNG
(Dipeptidyl nitrile inhibitor, 25)
Show SMILES Cn1nc(cc1C(=O)N[C@@H](Cc1cccc(Cl)c1)C(=O)NCC#N)C(C)(C)C |r|
Show InChI InChI=1S/C20H24ClN5O2/c1-20(2,3)17-12-16(26(4)25-17)19(28)24-15(18(27)23-9-8-22)11-13-6-5-7-14(21)10-13/h5-7,10,12,15H,9,11H2,1-4H3,(H,23,27)(H,24,28)/t15-/m0/s1
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 1.30n/an/an/an/an/an/an/an/a


TBA

Assay Description
Inhibition of human cathepsin L using Z-Phe-Arg-7-amido-4-methylcoumarin as substrate preincubated for 2 mins followed by substrate addition by fluor...

Citation and Details

Article DOI: 10.1016/j.bmc.2020.115743
BindingDB Entry DOI: 10.7270/Q27H1P7R
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))		BDBM50031942
PNG
((6aR,9R)-4,6a,7-Trimethyl-4,6,6a,7,8,9-hexahydro-i...)
Show SMILES CC[C@@H](CO)NC(=O)[C@H]1CN(C)[C@@H]2Cc3cn(C)c4cccc(C2=C1)c34 |r,c:24|
Show InChI InChI=1S/C21H27N3O2/c1-4-15(12-25)22-21(26)14-8-17-16-6-5-7-18-20(16)13(10-23(18)2)9-19(17)24(3)11-14/h5-8,10,14-15,19,25H,4,9,11-12H2,1-3H3,(H,22,26)/t14-,15+,19-/m1/s1
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 1.58n/an/an/an/an/an/an/an/a



Angelini Santa Palomba Research Center

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from human 5HT2AR expressed in CHOK1 cells

J Med Chem 55: 9446-66 (2012)


Article DOI: 10.1021/jm300573d
BindingDB Entry DOI: 10.7270/Q27082JT
More data for this
Ligand-Target Pair
Cruzipain


(Trypanosoma cruzi)		BDBM50451631
PNG
(CHEMBL4212454)
Show SMILES CN(C#N)N(C)C(=O)[C@H](Cc1ccccc1)NC(=O)c1cc(nn1C)C(C)(C)C |r|
Show InChI InChI=1S/C21H28N6O2/c1-21(2,3)18-13-17(26(5)24-18)19(28)23-16(12-15-10-8-7-9-11-15)20(29)27(6)25(4)14-22/h7-11,13,16H,12H2,1-6H3,(H,23,28)/t16-/m0/s1
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 1.60n/an/an/an/an/an/an/an/a


TBA

Assay Description
Inhibition of recombinant Trypanosoma cruzi cruzain using Z-Phe-Arg-7-amido-4-methylcoumarin as substrate preincubated for 2 mins followed by substra...

Citation and Details

Article DOI: 10.1016/j.bmc.2020.115743
BindingDB Entry DOI: 10.7270/Q27H1P7R
More data for this
Ligand-Target Pair
Cruzipain


(Trypanosoma cruzi)		BDBM50451625
PNG
(CHEMBL4217414)
Show SMILES CC(C)C[C@H](NC(=O)c1cc(nn1C)C(C)(C)C)C(=O)N(C)N(C)C#N |r|
Show InChI InChI=1S/C18H30N6O2/c1-12(2)9-13(17(26)24(8)22(6)11-19)20-16(25)14-10-15(18(3,4)5)21-23(14)7/h10,12-13H,9H2,1-8H3,(H,20,25)/t13-/m0/s1
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 1.60n/an/an/an/an/an/an/an/a


TBA

Assay Description
Inhibition of recombinant Trypanosoma cruzi cruzain using Z-Phe-Arg-7-amido-4-methylcoumarin as substrate preincubated for 2 mins followed by substra...

Citation and Details

Article DOI: 10.1016/j.bmc.2020.115743
BindingDB Entry DOI: 10.7270/Q27H1P7R
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 4


(Homo sapiens (Human))		BDBM50398965
PNG
(CHEMBL2179670)
Show SMILES CC(=O)Nc1ccc(CCN2CCC(COc3nc4ccccc4c4cn(C)cc34)CC2)cc1
Show InChI InChI=1S/C28H32N4O2/c1-20(33)29-23-9-7-21(8-10-23)11-14-32-15-12-22(13-16-32)19-34-28-26-18-31(2)17-25(26)24-5-3-4-6-27(24)30-28/h3-10,17-18,22H,11-16,19H2,1-2H3,(H,29,33)
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 2n/an/an/an/an/an/an/an/a



Angelini Santa Palomba Research Center

Curated by ChEMBL


Assay Description
Displacement of [3H](1-(2-(methylsulfonamido)ethyl)piperidin-4-yl)methyl 1-methyl-1H-indole-3-carboxylate from human 5HT4R expressed in HEK293 cells

J Med Chem 55: 9446-66 (2012)


Article DOI: 10.1021/jm300573d
BindingDB Entry DOI: 10.7270/Q27082JT
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 4


(Homo sapiens (Human))		BDBM50398963
PNG
(CHEMBL2179674)
Show SMILES Cn1cc2c(OCC3CCN(CCc4ccc(cc4)C(O)=O)CC3)nc3ccccc3c2c1
Show InChI InChI=1S/C27H29N3O3/c1-29-16-23-22-4-2-3-5-25(22)28-26(24(23)17-29)33-18-20-11-14-30(15-12-20)13-10-19-6-8-21(9-7-19)27(31)32/h2-9,16-17,20H,10-15,18H2,1H3,(H,31,32)
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 2n/an/an/an/an/an/an/an/a



Angelini Santa Palomba Research Center

Curated by ChEMBL


Assay Description
Displacement of [3H](1-(2-(methylsulfonamido)ethyl)piperidin-4-yl)methyl 1-methyl-1H-indole-3-carboxylate from human 5HT4R expressed in HEK293 cells

J Med Chem 55: 9446-66 (2012)


Article DOI: 10.1021/jm300573d
BindingDB Entry DOI: 10.7270/Q27082JT
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 4


(Homo sapiens (Human))		BDBM50398972
PNG
(CHEMBL2179678)
Show SMILES Cn1cc2c(OCC3CCN(CCc4ccccc4)CC3)nc3ccccc3c2c1
Show InChI InChI=1S/C26H29N3O/c1-28-17-23-22-9-5-6-10-25(22)27-26(24(23)18-28)30-19-21-12-15-29(16-13-21)14-11-20-7-3-2-4-8-20/h2-10,17-18,21H,11-16,19H2,1H3
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 2n/an/an/an/an/an/an/an/a



Angelini Santa Palomba Research Center

Curated by ChEMBL


Assay Description
Displacement of [3H](1-(2-(methylsulfonamido)ethyl)piperidin-4-yl)methyl 1-methyl-1H-indole-3-carboxylate from human 5HT4R expressed in HEK293 cells

J Med Chem 55: 9446-66 (2012)


Article DOI: 10.1021/jm300573d
BindingDB Entry DOI: 10.7270/Q27082JT
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 4


(Homo sapiens (Human))		BDBM50398969
PNG
(CHEMBL2179676)
Show SMILES Cn1cc2c(OCC3CCN(CCN4CCOCC4)CC3)nc3ccccc3c2c1
Show InChI InChI=1S/C24H32N4O2/c1-26-16-21-20-4-2-3-5-23(20)25-24(22(21)17-26)30-18-19-6-8-27(9-7-19)10-11-28-12-14-29-15-13-28/h2-5,16-17,19H,6-15,18H2,1H3
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 2.51n/an/an/an/an/an/an/an/a



Angelini Santa Palomba Research Center

Curated by ChEMBL


Assay Description
Displacement of [3H](1-(2-(methylsulfonamido)ethyl)piperidin-4-yl)methyl 1-methyl-1H-indole-3-carboxylate from human 5HT4R expressed in HEK293 cells

J Med Chem 55: 9446-66 (2012)


Article DOI: 10.1021/jm300573d
BindingDB Entry DOI: 10.7270/Q27082JT
More data for this
Ligand-Target Pair
Procathepsin L


(Homo sapiens (Human))		BDBM50554304
PNG
(CHEMBL4752430)
Show SMILES Cn1nc(cc1C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC#N)C(C)(C)C |r|
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 4n/an/an/an/an/an/an/an/a


TBA

Assay Description
Inhibition of human cathepsin L using Z-Phe-Arg-7-amido-4-methylcoumarin as substrate preincubated for 2 mins followed by substrate addition by fluor...

Citation and Details

Article DOI: 10.1016/j.bmc.2020.115743
BindingDB Entry DOI: 10.7270/Q27H1P7R
More data for this
Ligand-Target Pair
Procathepsin L


(Homo sapiens (Human))		BDBM50554312
PNG
(CHEMBL4792408)
Show SMILES CC(C)C[C@H](NC(=O)C1(CC1)c1ccccc1)C(=O)NC1(CC1)C#N |r|
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 5n/an/an/an/an/an/an/an/a


TBA

Assay Description
Inhibition of human cathepsin L using Z-Phe-Arg-7-amido-4-methylcoumarin as substrate preincubated for 2 mins followed by substrate addition by fluor...

Citation and Details

Article DOI: 10.1016/j.bmc.2020.115743
BindingDB Entry DOI: 10.7270/Q27H1P7R
More data for this
Ligand-Target Pair
Procathepsin L


(Homo sapiens (Human))		BDBM50554305
PNG
(CHEMBL4776795)
Show SMILES Cn1nc(cc1C(=O)N[C@@H](Cc1ccccc1)C(=O)NC1(CC1)C#N)C(C)(C)C |r|
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 5n/an/an/an/an/an/an/an/a


TBA

Assay Description
Inhibition of human cathepsin L using Z-Phe-Arg-7-amido-4-methylcoumarin as substrate preincubated for 2 mins followed by substrate addition by fluor...

Citation and Details

Article DOI: 10.1016/j.bmc.2020.115743
BindingDB Entry DOI: 10.7270/Q27H1P7R
More data for this
Ligand-Target Pair
Procathepsin L


(Homo sapiens (Human))		BDBM50554310
PNG
(CHEMBL4760625)
Show SMILES CC(C)C[C@H](NC(=O)C1(CCC1)c1ccccc1)C(=O)NC1(CC1)C#N |r|
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 5n/an/an/an/an/an/an/an/a


TBA

Assay Description
Inhibition of human cathepsin L using Z-Phe-Arg-7-amido-4-methylcoumarin as substrate preincubated for 2 mins followed by substrate addition by fluor...

Citation and Details

Article DOI: 10.1016/j.bmc.2020.115743
BindingDB Entry DOI: 10.7270/Q27H1P7R
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 4


(Homo sapiens (Human))		BDBM50398968
PNG
(CHEMBL2179675)
Show SMILES Cn1cc2c(OCC3CCN(CCc4ccc(N)cc4)CC3)nc3ccccc3c2c1
Show InChI InChI=1S/C26H30N4O/c1-29-16-23-22-4-2-3-5-25(22)28-26(24(23)17-29)31-18-20-11-14-30(15-12-20)13-10-19-6-8-21(27)9-7-19/h2-9,16-17,20H,10-15,18,27H2,1H3
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 5.01n/an/an/an/an/an/an/an/a



Angelini Santa Palomba Research Center

Curated by ChEMBL


Assay Description
Displacement of [3H](1-(2-(methylsulfonamido)ethyl)piperidin-4-yl)methyl 1-methyl-1H-indole-3-carboxylate from human 5HT4R expressed in HEK293 cells

J Med Chem 55: 9446-66 (2012)


Article DOI: 10.1021/jm300573d
BindingDB Entry DOI: 10.7270/Q27082JT
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 4


(Homo sapiens (Human))		BDBM50398973
PNG
(CHEMBL2179679)
Show SMILES CCCCN1CCC(COc2nc3ccccc3c3cn(C)cc23)CC1
Show InChI InChI=1S/C22H29N3O/c1-3-4-11-25-12-9-17(10-13-25)16-26-22-20-15-24(2)14-19(20)18-7-5-6-8-21(18)23-22/h5-8,14-15,17H,3-4,9-13,16H2,1-2H3
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 7.94n/an/an/an/an/an/an/an/a



Angelini Santa Palomba Research Center

Curated by ChEMBL


Assay Description
Displacement of [3H](1-(2-(methylsulfonamido)ethyl)piperidin-4-yl)methyl 1-methyl-1H-indole-3-carboxylate from human 5HT4R expressed in HEK293 cells

J Med Chem 55: 9446-66 (2012)


Article DOI: 10.1021/jm300573d
BindingDB Entry DOI: 10.7270/Q27082JT
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))		BDBM50398978
PNG
(CHEMBL2179704)
Show SMILES CC(C)n1nc(C(=O)NCC2CCN(CCc3ccc(O)cc3)CC2)c2ccccc12
Show InChI InChI=1S/C25H32N4O2/c1-18(2)29-23-6-4-3-5-22(23)24(27-29)25(31)26-17-20-12-15-28(16-13-20)14-11-19-7-9-21(30)10-8-19/h3-10,18,20,30H,11-17H2,1-2H3,(H,26,31)
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 10n/an/an/an/an/an/an/an/a



Angelini Santa Palomba Research Center

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from human 5HT2AR expressed in CHOK1 cells

J Med Chem 55: 9446-66 (2012)


Article DOI: 10.1021/jm300573d
BindingDB Entry DOI: 10.7270/Q27082JT
More data for this
Ligand-Target Pair
Procathepsin L


(Homo sapiens (Human))		BDBM50554300
PNG
(CHEMBL4792949)
Show SMILES Brc1cncc(c1)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC#N |r|
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 10n/an/an/an/an/an/an/an/a


TBA

Assay Description
Inhibition of human cathepsin L using Z-Phe-Arg-7-amido-4-methylcoumarin as substrate preincubated for 2 mins followed by substrate addition by fluor...

Citation and Details

Article DOI: 10.1016/j.bmc.2020.115743
BindingDB Entry DOI: 10.7270/Q27H1P7R
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 4


(Homo sapiens (Human))		BDBM50398967
PNG
(CHEMBL2179672)
Show SMILES Cn1cc2c(OCC3CCN(CCc4ccc(CO)cc4)CC3)nc3ccccc3c2c1
Show InChI InChI=1S/C27H31N3O2/c1-29-16-24-23-4-2-3-5-26(23)28-27(25(24)17-29)32-19-22-11-14-30(15-12-22)13-10-20-6-8-21(18-31)9-7-20/h2-9,16-17,22,31H,10-15,18-19H2,1H3
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 10n/an/an/an/an/an/an/an/a



Angelini Santa Palomba Research Center

Curated by ChEMBL


Assay Description
Displacement of [3H](1-(2-(methylsulfonamido)ethyl)piperidin-4-yl)methyl 1-methyl-1H-indole-3-carboxylate from human 5HT4R expressed in HEK293 cells

J Med Chem 55: 9446-66 (2012)


Article DOI: 10.1021/jm300573d
BindingDB Entry DOI: 10.7270/Q27082JT
More data for this
Ligand-Target Pair
Carbonic anhydrase 2


(Homo sapiens (Human))		BDBM10880
PNG
(AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)
Show SMILES CC(=O)Nc1nnc(s1)S(N)(=O)=O
Show InChI InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9)
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 12n/an/an/an/an/an/an/an/a



"Magna Gr£cia" University of Catanzaro

Curated by ChEMBL


Assay Description
Inhibition of recombinant human carbonic anhydrase 2 preincubated with enzyme for 15 mins by phenol red dye based stopped flow CO2 hydration assay

Eur J Med Chem 181: (2019)


Article DOI: 10.1016/j.ejmech.2019.111565
BindingDB Entry DOI: 10.7270/Q2QF8X7Z
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Procathepsin L


(Homo sapiens (Human))		BDBM50554308
PNG
(CHEMBL4761511)
Show SMILES CC(C)C[C@H](NC(=O)c1cc(nn1C)C(C)(C)C)C(=O)NC1(CC1)C#N |r|
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 13n/an/an/an/an/an/an/an/a


TBA

Assay Description
Inhibition of human cathepsin L using Z-Phe-Arg-7-amido-4-methylcoumarin as substrate preincubated for 2 mins followed by substrate addition by fluor...

Citation and Details

Article DOI: 10.1016/j.bmc.2020.115743
BindingDB Entry DOI: 10.7270/Q27H1P7R
More data for this
Ligand-Target Pair
Cruzipain


(Trypanosoma cruzi)		BDBM31992
PNG
(Dipeptidyl nitrile inhibitor, 25)
Show SMILES Cn1nc(cc1C(=O)N[C@@H](Cc1cccc(Cl)c1)C(=O)NCC#N)C(C)(C)C |r|
Show InChI InChI=1S/C20H24ClN5O2/c1-20(2,3)17-12-16(26(4)25-17)19(28)24-15(18(27)23-9-8-22)11-13-6-5-7-14(21)10-13/h5-7,10,12,15H,9,11H2,1-4H3,(H,23,27)(H,24,28)/t15-/m0/s1
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 16n/an/an/an/an/an/an/an/a


TBA

Assay Description
Inhibition of recombinant Trypanosoma cruzi cruzain using Z-Phe-Arg-7-amido-4-methylcoumarin as substrate preincubated for 2 mins followed by substra...

Citation and Details

Article DOI: 10.1016/j.bmc.2020.115743
BindingDB Entry DOI: 10.7270/Q27H1P7R
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 4


(Homo sapiens (Human))		BDBM50398966
PNG
(CHEMBL2179671)
Show SMILES COCc1ccc(CCN2CCC(COc3nc4ccccc4c4cn(C)cc34)CC2)cc1
Show InChI InChI=1S/C28H33N3O2/c1-30-17-25-24-5-3-4-6-27(24)29-28(26(25)18-30)33-20-23-12-15-31(16-13-23)14-11-21-7-9-22(10-8-21)19-32-2/h3-10,17-18,23H,11-16,19-20H2,1-2H3
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 19.9n/an/an/an/an/an/an/an/a



Angelini Santa Palomba Research Center

Curated by ChEMBL


Assay Description
Displacement of [3H](1-(2-(methylsulfonamido)ethyl)piperidin-4-yl)methyl 1-methyl-1H-indole-3-carboxylate from human 5HT4R expressed in HEK293 cells

J Med Chem 55: 9446-66 (2012)


Article DOI: 10.1021/jm300573d
BindingDB Entry DOI: 10.7270/Q27082JT
More data for this
Ligand-Target Pair
Cruzipain


(Trypanosoma cruzi)		BDBM50554310
PNG
(CHEMBL4760625)
Show SMILES CC(C)C[C@H](NC(=O)C1(CCC1)c1ccccc1)C(=O)NC1(CC1)C#N |r|
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 20n/an/an/an/an/an/an/an/a


TBA

Assay Description
Inhibition of recombinant Trypanosoma cruzi cruzain using Z-Phe-Arg-7-amido-4-methylcoumarin as substrate preincubated for 2 mins followed by substra...

Citation and Details

Article DOI: 10.1016/j.bmc.2020.115743
BindingDB Entry DOI: 10.7270/Q27H1P7R
More data for this
Ligand-Target Pair
Procathepsin L


(Homo sapiens (Human))		BDBM50502834
PNG
(CHEMBL4442543)
Show SMILES CC(C)C[C@H](NC(=O)c1ccccc1)C(=O)NC1(CC1)C#N |r|
Show InChI InChI=1S/C17H21N3O2/c1-12(2)10-14(16(22)20-17(11-18)8-9-17)19-15(21)13-6-4-3-5-7-13/h3-7,12,14H,8-10H2,1-2H3,(H,19,21)(H,20,22)/t14-/m0/s1
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 20n/an/an/an/an/an/an/an/a


TBA

Assay Description
Inhibition of human cathepsin L using Z-Phe-Arg-7-amido-4-methylcoumarin as substrate preincubated for 2 mins followed by substrate addition by fluor...

Citation and Details

Article DOI: 10.1016/j.bmc.2020.115743
BindingDB Entry DOI: 10.7270/Q27H1P7R
More data for this
Ligand-Target Pair
Procathepsin L


(Homo sapiens (Human))		BDBM31970
PNG
(Dipeptidyl nitrile inhibitor, 1)
Show SMILES Clc1cccc(C[C@H](NC(=O)c2ccccc2)C(=O)NCC#N)c1 |r|
Show InChI InChI=1S/C18H16ClN3O2/c19-15-8-4-5-13(11-15)12-16(18(24)21-10-9-20)22-17(23)14-6-2-1-3-7-14/h1-8,11,16H,10,12H2,(H,21,24)(H,22,23)/t16-/m0/s1
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 20n/an/an/an/an/an/an/an/a


TBA

Assay Description
Inhibition of human cathepsin L using Z-Phe-Arg-7-amido-4-methylcoumarin as substrate preincubated for 2 mins followed by substrate addition by fluor...

Citation and Details

Article DOI: 10.1016/j.bmc.2020.115743
BindingDB Entry DOI: 10.7270/Q27H1P7R
More data for this
Ligand-Target Pair
Procathepsin L


(Homo sapiens (Human))		BDBM50554306
PNG
(CHEMBL4741237)
Show SMILES Cn1nc(cc1C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC#N)C(F)(F)F |r|
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 25n/an/an/an/an/an/an/an/a


TBA

Assay Description
Inhibition of human cathepsin L using Z-Phe-Arg-7-amido-4-methylcoumarin as substrate preincubated for 2 mins followed by substrate addition by fluor...

Citation and Details

Article DOI: 10.1016/j.bmc.2020.115743
BindingDB Entry DOI: 10.7270/Q27H1P7R
More data for this
Ligand-Target Pair
Procathepsin L


(Homo sapiens (Human))		BDBM50554307
PNG
(CHEMBL4784502)
Show SMILES CC(C)C[C@H](NC(=O)c1cc(nn1C)C(C)(C)C)C(=O)NCC#N |r|
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 25n/an/an/an/an/an/an/an/a


TBA

Assay Description
Inhibition of human cathepsin L using Z-Phe-Arg-7-amido-4-methylcoumarin as substrate preincubated for 2 mins followed by substrate addition by fluor...

Citation and Details

Article DOI: 10.1016/j.bmc.2020.115743
BindingDB Entry DOI: 10.7270/Q27H1P7R
More data for this
Ligand-Target Pair
Cruzipain


(Trypanosoma cruzi)		BDBM50554308
PNG
(CHEMBL4761511)
Show SMILES CC(C)C[C@H](NC(=O)c1cc(nn1C)C(C)(C)C)C(=O)NC1(CC1)C#N |r|
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PubMed
 25n/an/an/an/an/an/an/an/a


TBA

Assay Description
Inhibition of recombinant Trypanosoma cruzi cruzain using Z-Phe-Arg-7-amido-4-methylcoumarin as substrate preincubated for 2 mins followed by substra...

Citation and Details

Article DOI: 10.1016/j.bmc.2020.115743
BindingDB Entry DOI: 10.7270/Q27H1P7R
More data for this
Ligand-Target Pair
Cruzipain


(Trypanosoma cruzi)		BDBM50554312
PNG
(CHEMBL4792408)
Show SMILES CC(C)C[C@H](NC(=O)C1(CC1)c1ccccc1)C(=O)NC1(CC1)C#N |r|
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 25n/an/an/an/an/an/an/an/a


TBA

Assay Description
Inhibition of recombinant Trypanosoma cruzi cruzain using Z-Phe-Arg-7-amido-4-methylcoumarin as substrate preincubated for 2 mins followed by substra...

Citation and Details

Article DOI: 10.1016/j.bmc.2020.115743
BindingDB Entry DOI: 10.7270/Q27H1P7R
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 4


(Homo sapiens (Human))		BDBM50398982
PNG
(CHEMBL2179698)
Show SMILES CC(C)n1nc(C(=O)NCC2CC[N+](C)(CCc3ccccc3)CC2)c2ccccc12
Show InChI InChI=1S/C26H34N4O.HI/c1-20(2)29-24-12-8-7-11-23(24)25(28-29)26(31)27-19-22-14-17-30(3,18-15-22)16-13-21-9-5-4-6-10-21;/h4-12,20,22H,13-19H2,1-3H3;1H
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PubMed
 31.6n/an/an/an/an/an/an/an/a



Angelini Santa Palomba Research Center

Curated by ChEMBL


Assay Description
Displacement of [3H](1-(2-(methylsulfonamido)ethyl)piperidin-4-yl)methyl 1-methyl-1H-indole-3-carboxylate from human 5HT4R expressed in HEK293 cells

J Med Chem 55: 9446-66 (2012)


Article DOI: 10.1021/jm300573d
BindingDB Entry DOI: 10.7270/Q27082JT
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))		BDBM50398985
PNG
(CHEMBL2177130)
Show SMILES CC(C)n1nc(C(=O)NCC2CCN(CCc3ccccc3)CC2)c2ccccc12
Show InChI InChI=1S/C25H32N4O/c1-19(2)29-23-11-7-6-10-22(23)24(27-29)25(30)26-18-21-13-16-28(17-14-21)15-12-20-8-4-3-5-9-20/h3-11,19,21H,12-18H2,1-2H3,(H,26,30)
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 31.6n/an/an/an/an/an/an/an/a



Angelini Santa Palomba Research Center

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from human 5HT2AR expressed in CHOK1 cells

J Med Chem 55: 9446-66 (2012)


Article DOI: 10.1021/jm300573d
BindingDB Entry DOI: 10.7270/Q27082JT
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))		BDBM50398967
PNG
(CHEMBL2179672)
Show SMILES Cn1cc2c(OCC3CCN(CCc4ccc(CO)cc4)CC3)nc3ccccc3c2c1
Show InChI InChI=1S/C27H31N3O2/c1-29-16-24-23-4-2-3-5-26(23)28-27(25(24)17-29)32-19-22-11-14-30(15-12-22)13-10-20-6-8-21(18-31)9-7-20/h2-9,16-17,22,31H,10-15,18-19H2,1H3
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 31.6n/an/an/an/an/an/an/an/a



Angelini Santa Palomba Research Center

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from human 5HT2AR expressed in CHOK1 cells

J Med Chem 55: 9446-66 (2012)


Article DOI: 10.1021/jm300573d
BindingDB Entry DOI: 10.7270/Q27082JT
More data for this
Ligand-Target Pair
Procathepsin L


(Homo sapiens (Human))		BDBM50554311
PNG
(CHEMBL4750552)
Show SMILES CC(C)C[C@H](NC(=O)C(F)(F)c1ccccc1)C(=O)NC1(CC1)C#N |r|
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 32n/an/an/an/an/an/an/an/a


TBA

Assay Description
Inhibition of human cathepsin L using Z-Phe-Arg-7-amido-4-methylcoumarin as substrate preincubated for 2 mins followed by substrate addition by fluor...

Citation and Details

Article DOI: 10.1016/j.bmc.2020.115743
BindingDB Entry DOI: 10.7270/Q27H1P7R
More data for this
Ligand-Target Pair
Cruzipain


(Trypanosoma cruzi)		BDBM50554309
PNG
(CHEMBL4792937)
Show SMILES CC(C)C[C@H](NC(=O)Cc1ccccc1)C(=O)NC1(CC1)C#N |r|
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 40n/an/an/an/an/an/an/an/a


TBA

Assay Description
Inhibition of recombinant Trypanosoma cruzi cruzain using Z-Phe-Arg-7-amido-4-methylcoumarin as substrate preincubated for 2 mins followed by substra...

Citation and Details

Article DOI: 10.1016/j.bmc.2020.115743
BindingDB Entry DOI: 10.7270/Q27H1P7R
More data for this
Ligand-Target Pair
Procathepsin L


(Homo sapiens (Human))		BDBM50554313
PNG
(CHEMBL4763131)
Show SMILES CC(C)C[C@H](NC(=O)C(C)(C)c1ccccc1)C(=O)NC1(CC1)C#N |r|
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 40n/an/an/an/an/an/an/an/a


TBA

Assay Description
Inhibition of human cathepsin L using Z-Phe-Arg-7-amido-4-methylcoumarin as substrate preincubated for 2 mins followed by substrate addition by fluor...

Citation and Details

Article DOI: 10.1016/j.bmc.2020.115743
BindingDB Entry DOI: 10.7270/Q27H1P7R
More data for this
Ligand-Target Pair
Procathepsin L


(Homo sapiens (Human))		BDBM50502835
PNG
(CHEMBL4463665)
Show SMILES O=C(NC1(CC1)C#N)[C@H](Cc1ccccc1)NC(=O)c1ccccc1 |r|
Show InChI InChI=1S/C20H19N3O2/c21-14-20(11-12-20)23-19(25)17(13-15-7-3-1-4-8-15)22-18(24)16-9-5-2-6-10-16/h1-10,17H,11-13H2,(H,22,24)(H,23,25)/t17-/m0/s1
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 50n/an/an/an/an/an/an/an/a


TBA

Assay Description
Inhibition of human cathepsin L using Z-Phe-Arg-7-amido-4-methylcoumarin as substrate preincubated for 2 mins followed by substrate addition by fluor...

Citation and Details

Article DOI: 10.1016/j.bmc.2020.115743
BindingDB Entry DOI: 10.7270/Q27H1P7R
More data for this
Ligand-Target Pair
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