Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
High affinity nerve growth factor receptor (Homo sapiens (Human)) | BDBM50392788 (CHEMBL457614) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MMDB PC cid PC sid PDB UniChem | PDB Article PubMed | 0.360 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Zoetis Inc Curated by ChEMBL | Assay Description Inhibition of human active TRKA assessed as decrease in substrate phosphorylation incubated for 2 hrs using CSKtide as substrate in presence of ATP m... | Bioorg Med Chem Lett 29: (2019) Article DOI: 10.1016/j.bmcl.2019.126680 BindingDB Entry DOI: 10.7270/Q2280BVB | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
High affinity nerve growth factor receptor (Homo sapiens (Human)) | BDBM50557930 (CHEMBL4740028) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of human TRKA at active state by kinetic based analysis | Citation and Details Article DOI: 10.1039/c9md00554d BindingDB Entry DOI: 10.7270/Q23J3HNX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 6 (Homo sapiens (Human)) | BDBM28586 (1-{3-[(3-chlorophenyl)methoxy]-2-methylphenyl}pipe...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 0.600 | -52.1 | n/a | n/a | n/a | n/a | n/a | 7.5 | 22 |
Pfizer | Assay Description Competition experiments were performed in the presence radioligand with membrane protein (obtained from cells expressing the receptor) and test compo... | Bioorg Med Chem Lett 19: 2409-12 (2009) Article DOI: 10.1016/j.bmcl.2009.03.077 BindingDB Entry DOI: 10.7270/Q24T6GP5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 6 (Homo sapiens (Human)) | BDBM28583 (5-chloro-N-[4-methoxy-3-(piperazin-1-yl)phenyl]-3-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | 0.660 | -51.9 | n/a | n/a | n/a | n/a | n/a | 7.5 | 22 |
Pfizer | Assay Description Competition experiments were performed in the presence radioligand with membrane protein (obtained from cells expressing the receptor) and test compo... | Bioorg Med Chem Lett 19: 2409-12 (2009) Article DOI: 10.1016/j.bmcl.2009.03.077 BindingDB Entry DOI: 10.7270/Q24T6GP5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
High affinity nerve growth factor receptor (Homo sapiens (Human)) | BDBM50557930 (CHEMBL4740028) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of human TRKA at inactive state by kinetic based analysis | Citation and Details Article DOI: 10.1039/c9md00554d BindingDB Entry DOI: 10.7270/Q23J3HNX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 6 (Homo sapiens (Human)) | BDBM28584 (1-[3-(benzyloxy)-2-methylphenyl]piperazine | tolyl...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 1.30 | -50.2 | n/a | n/a | n/a | n/a | n/a | 7.5 | 22 |
Pfizer | Assay Description Competition experiments were performed in the presence radioligand with membrane protein (obtained from cells expressing the receptor) and test compo... | Bioorg Med Chem Lett 19: 2409-12 (2009) Article DOI: 10.1016/j.bmcl.2009.03.077 BindingDB Entry DOI: 10.7270/Q24T6GP5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 6 (Homo sapiens (Human)) | BDBM28635 (2-methyl-3-(piperidin-4-yl)phenyl naphthalene-1-su...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 1.5 | -50.4 | n/a | n/a | n/a | n/a | n/a | n/a | 25 |
Pfizer | Assay Description Competition experiments were performed in the presence radioligand with membrane protein (obtained from cells expressing the receptor) and test compo... | Bioorg Med Chem Lett 19: 2409-12 (2009) Article DOI: 10.1016/j.bmcl.2009.03.077 BindingDB Entry DOI: 10.7270/Q24T6GP5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 6 (Homo sapiens (Human)) | BDBM28620 (2-[1-(3-chlorophenyl)-2,2,2-trifluoroethoxy]-3-met...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 2.40 | -49.2 | n/a | n/a | n/a | n/a | n/a | n/a | 25 |
Pfizer | Assay Description Competition experiments were performed in the presence radioligand with membrane protein (obtained from cells expressing the receptor) and test compo... | Bioorg Med Chem Lett 19: 2409-12 (2009) Article DOI: 10.1016/j.bmcl.2009.03.077 BindingDB Entry DOI: 10.7270/Q24T6GP5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 6 (Homo sapiens (Human)) | BDBM28594 (4-{3-[(3-fluorophenyl)methoxy]-2-methylphenyl}pipe...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 2.5 | -48.6 | n/a | n/a | n/a | n/a | n/a | 7.5 | 22 |
Pfizer | Assay Description Competition experiments were performed in the presence radioligand with membrane protein (obtained from cells expressing the receptor) and test compo... | Bioorg Med Chem Lett 19: 2409-12 (2009) Article DOI: 10.1016/j.bmcl.2009.03.077 BindingDB Entry DOI: 10.7270/Q24T6GP5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 6 (Homo sapiens (Human)) | BDBM28636 (2-methyl-3-(piperidin-4-yl)phenyl naphthalene-2-su...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 2.70 | -48.9 | n/a | n/a | n/a | n/a | n/a | n/a | 25 |
Pfizer | Assay Description Competition experiments were performed in the presence radioligand with membrane protein (obtained from cells expressing the receptor) and test compo... | Bioorg Med Chem Lett 19: 2409-12 (2009) Article DOI: 10.1016/j.bmcl.2009.03.077 BindingDB Entry DOI: 10.7270/Q24T6GP5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 6 (Homo sapiens (Human)) | BDBM28603 (4-{3-[(1S)-1-(3-chlorophenyl)ethoxy]-2-methylpheny...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 2.80 | -48.3 | n/a | n/a | n/a | n/a | n/a | 7.5 | 22 |
Pfizer | Assay Description Competition experiments were performed in the presence radioligand with membrane protein (obtained from cells expressing the receptor) and test compo... | Bioorg Med Chem Lett 19: 2409-12 (2009) Article DOI: 10.1016/j.bmcl.2009.03.077 BindingDB Entry DOI: 10.7270/Q24T6GP5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 6 (Homo sapiens (Human)) | BDBM28595 (4-{3-[(3-chlorophenyl)methoxy]-2-methylphenyl}pipe...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 3.30 | -47.9 | n/a | n/a | n/a | n/a | n/a | 7.5 | 22 |
Pfizer | Assay Description Competition experiments were performed in the presence radioligand with membrane protein (obtained from cells expressing the receptor) and test compo... | Bioorg Med Chem Lett 19: 2409-12 (2009) Article DOI: 10.1016/j.bmcl.2009.03.077 BindingDB Entry DOI: 10.7270/Q24T6GP5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 6 (Homo sapiens (Human)) | BDBM28623 (4-[3-(3-chlorophenoxymethyl)-2-methylphenyl]piperi...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 3.5 | -48.3 | n/a | n/a | n/a | n/a | n/a | n/a | 25 |
Pfizer | Assay Description Competition experiments were performed in the presence radioligand with membrane protein (obtained from cells expressing the receptor) and test compo... | Bioorg Med Chem Lett 19: 2409-12 (2009) Article DOI: 10.1016/j.bmcl.2009.03.077 BindingDB Entry DOI: 10.7270/Q24T6GP5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
High affinity nerve growth factor receptor (Homo sapiens (Human)) | BDBM50392788 (CHEMBL457614) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MMDB PC cid PC sid PDB UniChem | PDB Article PubMed | 3.70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Zoetis Inc Curated by ChEMBL | Assay Description Inhibition of human inactive TRKA assessed as decrease in substrate phosphorylation incubated for 2 hrs using CSKtide as substrate in presence of ATP... | Bioorg Med Chem Lett 29: (2019) Article DOI: 10.1016/j.bmcl.2019.126680 BindingDB Entry DOI: 10.7270/Q2280BVB | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
5-hydroxytryptamine receptor 6 (Homo sapiens (Human)) | BDBM28621 (3-methyl-4-(piperidin-4-yl)-2-[2,2,2-trifluoro-1-(...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 4.30 | -47.8 | n/a | n/a | n/a | n/a | n/a | n/a | 25 |
Pfizer | Assay Description Competition experiments were performed in the presence radioligand with membrane protein (obtained from cells expressing the receptor) and test compo... | Bioorg Med Chem Lett 19: 2409-12 (2009) Article DOI: 10.1016/j.bmcl.2009.03.077 BindingDB Entry DOI: 10.7270/Q24T6GP5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 6 (Homo sapiens (Human)) | BDBM28628 (2-methyl-3-(piperidin-4-yl)phenyl 2-chlorobenzene-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 5.80 | -47.0 | n/a | n/a | n/a | n/a | n/a | n/a | 25 |
Pfizer | Assay Description Competition experiments were performed in the presence radioligand with membrane protein (obtained from cells expressing the receptor) and test compo... | Bioorg Med Chem Lett 19: 2409-12 (2009) Article DOI: 10.1016/j.bmcl.2009.03.077 BindingDB Entry DOI: 10.7270/Q24T6GP5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 6 (Homo sapiens (Human)) | BDBM28619 (2-[1-(3-chlorophenyl)propoxy]-3-methyl-4-(piperidi...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 6.40 | -46.8 | n/a | n/a | n/a | n/a | n/a | n/a | 25 |
Pfizer | Assay Description Competition experiments were performed in the presence radioligand with membrane protein (obtained from cells expressing the receptor) and test compo... | Bioorg Med Chem Lett 19: 2409-12 (2009) Article DOI: 10.1016/j.bmcl.2009.03.077 BindingDB Entry DOI: 10.7270/Q24T6GP5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 6 (Homo sapiens (Human)) | BDBM28624 (4-[3-(3-fluorophenoxymethyl)-2-methylphenyl]piperi...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 6.5 | -46.7 | n/a | n/a | n/a | n/a | n/a | n/a | 25 |
Pfizer | Assay Description Competition experiments were performed in the presence radioligand with membrane protein (obtained from cells expressing the receptor) and test compo... | Bioorg Med Chem Lett 19: 2409-12 (2009) Article DOI: 10.1016/j.bmcl.2009.03.077 BindingDB Entry DOI: 10.7270/Q24T6GP5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 6 (Homo sapiens (Human)) | BDBM28601 (4-{3-[(1S)-1-(3-fluorophenyl)ethoxy]-2-methylpheny...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 6.90 | -46.1 | n/a | n/a | n/a | n/a | n/a | 7.5 | 22 |
Pfizer | Assay Description Competition experiments were performed in the presence radioligand with membrane protein (obtained from cells expressing the receptor) and test compo... | Bioorg Med Chem Lett 19: 2409-12 (2009) Article DOI: 10.1016/j.bmcl.2009.03.077 BindingDB Entry DOI: 10.7270/Q24T6GP5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 6 (Homo sapiens (Human)) | BDBM28607 (2-[(3-chlorophenyl)methoxy]-3-methyl-4-(piperidin-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 8.10 | -46.2 | n/a | n/a | n/a | n/a | n/a | n/a | 25 |
Pfizer | Assay Description Competition experiments were performed in the presence radioligand with membrane protein (obtained from cells expressing the receptor) and test compo... | Bioorg Med Chem Lett 19: 2409-12 (2009) Article DOI: 10.1016/j.bmcl.2009.03.077 BindingDB Entry DOI: 10.7270/Q24T6GP5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 6 (Homo sapiens (Human)) | BDBM28589 (1-{3-[(3,4-difluorophenyl)methoxy]-2-methylphenyl}...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 9.30 | -45.4 | n/a | n/a | n/a | n/a | n/a | 7.5 | 22 |
Pfizer | Assay Description Competition experiments were performed in the presence radioligand with membrane protein (obtained from cells expressing the receptor) and test compo... | Bioorg Med Chem Lett 19: 2409-12 (2009) Article DOI: 10.1016/j.bmcl.2009.03.077 BindingDB Entry DOI: 10.7270/Q24T6GP5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 6 (Homo sapiens (Human)) | BDBM28631 (2-methyl-3-(piperidin-4-yl)phenyl 2-methylbenzene-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 10.1 | -45.6 | n/a | n/a | n/a | n/a | n/a | n/a | 25 |
Pfizer | Assay Description Competition experiments were performed in the presence radioligand with membrane protein (obtained from cells expressing the receptor) and test compo... | Bioorg Med Chem Lett 19: 2409-12 (2009) Article DOI: 10.1016/j.bmcl.2009.03.077 BindingDB Entry DOI: 10.7270/Q24T6GP5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 6 (Homo sapiens (Human)) | BDBM28585 (1-{3-[(3-fluorophenyl)methoxy]-2-methylphenyl}pipe...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 10.3 | -45.1 | n/a | n/a | n/a | n/a | n/a | 7.5 | 22 |
Pfizer | Assay Description Competition experiments were performed in the presence radioligand with membrane protein (obtained from cells expressing the receptor) and test compo... | Bioorg Med Chem Lett 19: 2409-12 (2009) Article DOI: 10.1016/j.bmcl.2009.03.077 BindingDB Entry DOI: 10.7270/Q24T6GP5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 6 (Homo sapiens (Human)) | BDBM28617 (2-[(1S)-1-(3-chlorophenyl)ethoxy]-3-methyl-4-(pipe...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 10.5 | -45.5 | n/a | n/a | n/a | n/a | n/a | n/a | 25 |
Pfizer | Assay Description Competition experiments were performed in the presence radioligand with membrane protein (obtained from cells expressing the receptor) and test compo... | Bioorg Med Chem Lett 19: 2409-12 (2009) Article DOI: 10.1016/j.bmcl.2009.03.077 BindingDB Entry DOI: 10.7270/Q24T6GP5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 6 (Homo sapiens (Human)) | BDBM28634 (2-methyl-3-(piperidin-4-yl)phenyl 4-ethylbenzene-1...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 11.3 | -45.4 | n/a | n/a | n/a | n/a | n/a | n/a | 25 |
Pfizer | Assay Description Competition experiments were performed in the presence radioligand with membrane protein (obtained from cells expressing the receptor) and test compo... | Bioorg Med Chem Lett 19: 2409-12 (2009) Article DOI: 10.1016/j.bmcl.2009.03.077 BindingDB Entry DOI: 10.7270/Q24T6GP5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 6 (Homo sapiens (Human)) | BDBM28588 (1-{3-[(2-fluorophenyl)methoxy]-2-methylphenyl}pipe...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 11.6 | -44.8 | n/a | n/a | n/a | n/a | n/a | 7.5 | 22 |
Pfizer | Assay Description Competition experiments were performed in the presence radioligand with membrane protein (obtained from cells expressing the receptor) and test compo... | Bioorg Med Chem Lett 19: 2409-12 (2009) Article DOI: 10.1016/j.bmcl.2009.03.077 BindingDB Entry DOI: 10.7270/Q24T6GP5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 6 (Homo sapiens (Human)) | BDBM28630 (2-methyl-3-(piperidin-4-yl)phenyl 2-fluorobenzene-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 13.6 | -44.9 | n/a | n/a | n/a | n/a | n/a | n/a | 25 |
Pfizer | Assay Description Competition experiments were performed in the presence radioligand with membrane protein (obtained from cells expressing the receptor) and test compo... | Bioorg Med Chem Lett 19: 2409-12 (2009) Article DOI: 10.1016/j.bmcl.2009.03.077 BindingDB Entry DOI: 10.7270/Q24T6GP5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 6 (Homo sapiens (Human)) | BDBM28632 (2-methyl-3-(piperidin-4-yl)phenyl 3-methylbenzene-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 15.1 | -44.6 | n/a | n/a | n/a | n/a | n/a | n/a | 25 |
Pfizer | Assay Description Competition experiments were performed in the presence radioligand with membrane protein (obtained from cells expressing the receptor) and test compo... | Bioorg Med Chem Lett 19: 2409-12 (2009) Article DOI: 10.1016/j.bmcl.2009.03.077 BindingDB Entry DOI: 10.7270/Q24T6GP5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 6 (Homo sapiens (Human)) | BDBM28587 (3-[2-methyl-3-(piperazin-1-yl)phenoxymethyl]benzon...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 15.3 | -44.2 | n/a | n/a | n/a | n/a | n/a | 7.5 | 22 |
Pfizer | Assay Description Competition experiments were performed in the presence radioligand with membrane protein (obtained from cells expressing the receptor) and test compo... | Bioorg Med Chem Lett 19: 2409-12 (2009) Article DOI: 10.1016/j.bmcl.2009.03.077 BindingDB Entry DOI: 10.7270/Q24T6GP5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 6 (Homo sapiens (Human)) | BDBM28608 (2-[(3-fluorophenyl)methoxy]-3-methyl-4-(piperidin-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 17.8 | -44.2 | n/a | n/a | n/a | n/a | n/a | n/a | 25 |
Pfizer | Assay Description Competition experiments were performed in the presence radioligand with membrane protein (obtained from cells expressing the receptor) and test compo... | Bioorg Med Chem Lett 19: 2409-12 (2009) Article DOI: 10.1016/j.bmcl.2009.03.077 BindingDB Entry DOI: 10.7270/Q24T6GP5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 6 (Homo sapiens (Human)) | BDBM28605 (4-{3-[1-(3-chlorophenyl)propoxy]-2-methylphenyl}pi...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 17.9 | -43.8 | n/a | n/a | n/a | n/a | n/a | 7.5 | 22 |
Pfizer | Assay Description Competition experiments were performed in the presence radioligand with membrane protein (obtained from cells expressing the receptor) and test compo... | Bioorg Med Chem Lett 19: 2409-12 (2009) Article DOI: 10.1016/j.bmcl.2009.03.077 BindingDB Entry DOI: 10.7270/Q24T6GP5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 6 (Homo sapiens (Human)) | BDBM28627 (2-methyl-3-(piperidin-4-yl)phenyl 3-fluorobenzene-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 18.4 | -44.2 | n/a | n/a | n/a | n/a | n/a | n/a | 25 |
Pfizer | Assay Description Competition experiments were performed in the presence radioligand with membrane protein (obtained from cells expressing the receptor) and test compo... | Bioorg Med Chem Lett 19: 2409-12 (2009) Article DOI: 10.1016/j.bmcl.2009.03.077 BindingDB Entry DOI: 10.7270/Q24T6GP5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 6 (Homo sapiens (Human)) | BDBM28609 (3-methyl-4-(piperidin-4-yl)-2-{[3-(trifluoromethyl...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 19.1 | -44.1 | n/a | n/a | n/a | n/a | n/a | n/a | 25 |
Pfizer | Assay Description Competition experiments were performed in the presence radioligand with membrane protein (obtained from cells expressing the receptor) and test compo... | Bioorg Med Chem Lett 19: 2409-12 (2009) Article DOI: 10.1016/j.bmcl.2009.03.077 BindingDB Entry DOI: 10.7270/Q24T6GP5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 6 (Homo sapiens (Human)) | BDBM28625 (2-methyl-3-(piperidin-4-yl)phenyl benzenesulfonate...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 19.6 | -44.0 | n/a | n/a | n/a | n/a | n/a | n/a | 25 |
Pfizer | Assay Description Competition experiments were performed in the presence radioligand with membrane protein (obtained from cells expressing the receptor) and test compo... | Bioorg Med Chem Lett 19: 2409-12 (2009) Article DOI: 10.1016/j.bmcl.2009.03.077 BindingDB Entry DOI: 10.7270/Q24T6GP5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
High affinity nerve growth factor receptor (Homo sapiens (Human)) | BDBM50502896 (CHEMBL4458913) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem | PDB Article PubMed | 21 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Zoetis Inc Curated by ChEMBL | Assay Description Inhibition of human inactive TRKA assessed as decrease in substrate phosphorylation incubated for 2 hrs using CSKtide as substrate in presence of ATP... | Bioorg Med Chem Lett 29: (2019) Article DOI: 10.1016/j.bmcl.2019.126680 BindingDB Entry DOI: 10.7270/Q2280BVB | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
5-hydroxytryptamine receptor 6 (Homo sapiens (Human)) | BDBM28629 (2-methyl-3-(piperidin-4-yl)phenyl 4-chlorobenzene-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 24.7 | -43.4 | n/a | n/a | n/a | n/a | n/a | n/a | 25 |
Pfizer | Assay Description Competition experiments were performed in the presence radioligand with membrane protein (obtained from cells expressing the receptor) and test compo... | Bioorg Med Chem Lett 19: 2409-12 (2009) Article DOI: 10.1016/j.bmcl.2009.03.077 BindingDB Entry DOI: 10.7270/Q24T6GP5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 6 (Homo sapiens (Human)) | BDBM28626 (2-methyl-3-(piperidin-4-yl)phenyl 3-chlorobenzene-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 26.1 | -43.3 | n/a | n/a | n/a | n/a | n/a | n/a | 25 |
Pfizer | Assay Description Competition experiments were performed in the presence radioligand with membrane protein (obtained from cells expressing the receptor) and test compo... | Bioorg Med Chem Lett 19: 2409-12 (2009) Article DOI: 10.1016/j.bmcl.2009.03.077 BindingDB Entry DOI: 10.7270/Q24T6GP5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 6 (Homo sapiens (Human)) | BDBM28633 (2-methyl-3-(piperidin-4-yl)phenyl 4-methylbenzene-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 28.9 | -43.0 | n/a | n/a | n/a | n/a | n/a | n/a | 25 |
Pfizer | Assay Description Competition experiments were performed in the presence radioligand with membrane protein (obtained from cells expressing the receptor) and test compo... | Bioorg Med Chem Lett 19: 2409-12 (2009) Article DOI: 10.1016/j.bmcl.2009.03.077 BindingDB Entry DOI: 10.7270/Q24T6GP5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 6 (Homo sapiens (Human)) | BDBM28604 (4-{3-[(1R)-1-(3-chlorophenyl)ethoxy]-2-methylpheny...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 39.5 | -41.8 | n/a | n/a | n/a | n/a | n/a | 7.5 | 22 |
Pfizer | Assay Description Competition experiments were performed in the presence radioligand with membrane protein (obtained from cells expressing the receptor) and test compo... | Bioorg Med Chem Lett 19: 2409-12 (2009) Article DOI: 10.1016/j.bmcl.2009.03.077 BindingDB Entry DOI: 10.7270/Q24T6GP5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 6 (Homo sapiens (Human)) | BDBM28602 (4-{3-[(1R)-1-(3-fluorophenyl)ethoxy]-2-methylpheny...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 39.8 | -41.8 | n/a | n/a | n/a | n/a | n/a | 7.5 | 22 |
Pfizer | Assay Description Competition experiments were performed in the presence radioligand with membrane protein (obtained from cells expressing the receptor) and test compo... | Bioorg Med Chem Lett 19: 2409-12 (2009) Article DOI: 10.1016/j.bmcl.2009.03.077 BindingDB Entry DOI: 10.7270/Q24T6GP5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 6 (Homo sapiens (Human)) | BDBM28598 (4-{3-[(3,4-difluorophenyl)methoxy]-2-methylphenyl}...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 42 | -41.7 | n/a | n/a | n/a | n/a | n/a | 7.5 | 22 |
Pfizer | Assay Description Competition experiments were performed in the presence radioligand with membrane protein (obtained from cells expressing the receptor) and test compo... | Bioorg Med Chem Lett 19: 2409-12 (2009) Article DOI: 10.1016/j.bmcl.2009.03.077 BindingDB Entry DOI: 10.7270/Q24T6GP5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 6 (Homo sapiens (Human)) | BDBM28592 (1-{2-methyl-3-[(1S)-1-phenylethoxy]phenyl}piperazi...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 45.6 | -41.5 | n/a | n/a | n/a | n/a | n/a | 7.5 | 22 |
Pfizer | Assay Description Competition experiments were performed in the presence radioligand with membrane protein (obtained from cells expressing the receptor) and test compo... | Bioorg Med Chem Lett 19: 2409-12 (2009) Article DOI: 10.1016/j.bmcl.2009.03.077 BindingDB Entry DOI: 10.7270/Q24T6GP5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 6 (Homo sapiens (Human)) | BDBM28615 (3-methyl-2-[(1S)-1-phenylethoxy]-4-(piperidin-4-yl...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 48.5 | -41.7 | n/a | n/a | n/a | n/a | n/a | n/a | 25 |
Pfizer | Assay Description Competition experiments were performed in the presence radioligand with membrane protein (obtained from cells expressing the receptor) and test compo... | Bioorg Med Chem Lett 19: 2409-12 (2009) Article DOI: 10.1016/j.bmcl.2009.03.077 BindingDB Entry DOI: 10.7270/Q24T6GP5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 6 (Homo sapiens (Human)) | BDBM28611 (2-[(4-chlorophenyl)methoxy]-3-methyl-4-(piperidin-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 50 | -41.7 | n/a | n/a | n/a | n/a | n/a | n/a | 25 |
Pfizer | Assay Description Competition experiments were performed in the presence radioligand with membrane protein (obtained from cells expressing the receptor) and test compo... | Bioorg Med Chem Lett 19: 2409-12 (2009) Article DOI: 10.1016/j.bmcl.2009.03.077 BindingDB Entry DOI: 10.7270/Q24T6GP5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 6 (Homo sapiens (Human)) | BDBM28590 (1-{3-[(3,4-dichlorophenyl)methoxy]-2-methylphenyl}...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 61.6 | -40.7 | n/a | n/a | n/a | n/a | n/a | 7.5 | 22 |
Pfizer | Assay Description Competition experiments were performed in the presence radioligand with membrane protein (obtained from cells expressing the receptor) and test compo... | Bioorg Med Chem Lett 19: 2409-12 (2009) Article DOI: 10.1016/j.bmcl.2009.03.077 BindingDB Entry DOI: 10.7270/Q24T6GP5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
High affinity nerve growth factor receptor (Homo sapiens (Human)) | BDBM50557927 (CHEMBL4788009) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid PDB UniChem | PDB Article PubMed | 66 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of human TRKA at inactive state by kinetic based analysis | Citation and Details Article DOI: 10.1039/c9md00554d BindingDB Entry DOI: 10.7270/Q23J3HNX | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
High affinity nerve growth factor receptor (Homo sapiens (Human)) | BDBM50502896 (CHEMBL4458913) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem | PDB Article PubMed | 67 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Zoetis Inc Curated by ChEMBL | Assay Description Inhibition of human active TRKA assessed as decrease in substrate phosphorylation incubated for 2 hrs using CSKtide as substrate in presence of ATP m... | Bioorg Med Chem Lett 29: (2019) Article DOI: 10.1016/j.bmcl.2019.126680 BindingDB Entry DOI: 10.7270/Q2280BVB | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
5-hydroxytryptamine receptor 6 (Homo sapiens (Human)) | BDBM28593 (1-{2-methyl-3-[(1R)-1-phenylethoxy]phenyl}piperazi...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 70.7 | -40.4 | n/a | n/a | n/a | n/a | n/a | 7.5 | 22 |
Pfizer | Assay Description Competition experiments were performed in the presence radioligand with membrane protein (obtained from cells expressing the receptor) and test compo... | Bioorg Med Chem Lett 19: 2409-12 (2009) Article DOI: 10.1016/j.bmcl.2009.03.077 BindingDB Entry DOI: 10.7270/Q24T6GP5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 6 (Homo sapiens (Human)) | BDBM28597 (4-{2-methyl-3-[(3-methylphenyl)methoxy]phenyl}pipe...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 92.5 | -39.7 | n/a | n/a | n/a | n/a | n/a | 7.5 | 22 |
Pfizer | Assay Description Competition experiments were performed in the presence radioligand with membrane protein (obtained from cells expressing the receptor) and test compo... | Bioorg Med Chem Lett 19: 2409-12 (2009) Article DOI: 10.1016/j.bmcl.2009.03.077 BindingDB Entry DOI: 10.7270/Q24T6GP5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 6 (Homo sapiens (Human)) | BDBM28591 (1-[2-methyl-3-(pyridin-3-ylmethoxy)phenyl]piperazi...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 126 | -39.0 | n/a | n/a | n/a | n/a | n/a | 7.5 | 22 |
Pfizer | Assay Description Competition experiments were performed in the presence radioligand with membrane protein (obtained from cells expressing the receptor) and test compo... | Bioorg Med Chem Lett 19: 2409-12 (2009) Article DOI: 10.1016/j.bmcl.2009.03.077 BindingDB Entry DOI: 10.7270/Q24T6GP5 | |||||||||||
More data for this Ligand-Target Pair |
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