Found 1413 hits with Last Name = 'satala' and Initial = 'g' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
5-hydroxytryptamine receptor 7
(Homo sapiens (Human)) | BDBM21367
(6-{4-[2-(methylsulfanyl)phenyl]piperazin-1-yl}-N-(...)Show SMILES CSc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc23)CC1 Show InChI InChI=1S/C27H37N3OS/c1-32-26-15-7-6-14-25(26)30-20-18-29(19-21-30)17-8-2-3-16-27(31)28-24-13-9-11-22-10-4-5-12-23(22)24/h4-7,10,12,14-15,24H,2-3,8-9,11,13,16-21H2,1H3,(H,28,31) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
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CHEMBL MCE PC cid PC sid UniChem
Similars
| Article PubMed
| 0.220 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Jagiellonian University Medical College
Curated by ChEMBL
| Assay Description Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting |
Eur J Med Chem 78: 10-22 (2014)
Article DOI: 10.1016/j.ejmech.2014.03.005 BindingDB Entry DOI: 10.7270/Q2QN6899 |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 7
(Homo sapiens (Human)) | BDBM21367
(6-{4-[2-(methylsulfanyl)phenyl]piperazin-1-yl}-N-(...)Show SMILES CSc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc23)CC1 Show InChI InChI=1S/C27H37N3OS/c1-32-26-15-7-6-14-25(26)30-20-18-29(19-21-30)17-8-2-3-16-27(31)28-24-13-9-11-22-10-4-5-12-23(22)24/h4-7,10,12,14-15,24H,2-3,8-9,11,13,16-21H2,1H3,(H,28,31) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
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CHEMBL MCE PC cid PC sid UniChem
Similars
| Article PubMed
| 0.220 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Jagiellonian University Medical College
Curated by ChEMBL
| Assay Description Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr |
Eur J Med Chem 92: 202-11 (2015)
Article DOI: 10.1016/j.ejmech.2014.12.041 BindingDB Entry DOI: 10.7270/Q2TT4SNW |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 7
(Homo sapiens (Human)) | BDBM50393371
(CHEMBL2159465)Show SMILES CC(C)c1ccccc1OCCN1CCC(CC1)NS(=O)(=O)c1ccc(F)cc1 Show InChI InChI=1S/C22H29FN2O3S/c1-17(2)21-5-3-4-6-22(21)28-16-15-25-13-11-19(12-14-25)24-29(26,27)20-9-7-18(23)8-10-20/h3-10,17,19,24H,11-16H2,1-2H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 0.300 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr |
Eur J Med Chem 56: 348-360 (2012)
Article DOI: 10.1016/j.ejmech.2012.07.043 BindingDB Entry DOI: 10.7270/Q28P61N6 |
More data for this Ligand-Target Pair | |
D(2) dopamine receptor
(Homo sapiens (Human)) | BDBM50130293
(7-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy}...)Show SMILES Clc1cccc(N2CCN(CCCCOc3ccc4CCC(=O)Nc4c3)CC2)c1Cl Show InChI InChI=1S/C23H27Cl2N3O2/c24-19-4-3-5-21(23(19)25)28-13-11-27(12-14-28)10-1-2-15-30-18-8-6-17-7-9-22(29)26-20(17)16-18/h3-6,8,16H,1-2,7,9-15H2,(H,26,29) | PDB
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Similars
| DrugBank Article PubMed
| 0.300 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.ejmech.2022.114193 BindingDB Entry DOI: 10.7270/Q2WS8Z8T |
More data for this Ligand-Target Pair | |
D(2) dopamine receptor
(Homo sapiens (Human)) | BDBM50443101
(Cariprazine | RGH-188)Show SMILES CN(C)C(=O)N[C@H]1CC[C@H](CCN2CCN(CC2)c2cccc(Cl)c2Cl)CC1 |r,wU:6.5,wD:9.9,(-.77,5.69,;.57,4.92,;1.9,5.69,;.57,3.38,;-.77,2.61,;1.9,2.61,;1.9,1.07,;3.23,.3,;3.23,-1.24,;1.9,-2.01,;1.9,-3.55,;3.23,-4.32,;3.23,-5.86,;4.57,-6.63,;4.57,-8.17,;3.23,-8.94,;1.9,-8.17,;1.9,-6.63,;3.23,-10.48,;4.57,-11.25,;4.57,-12.79,;3.23,-13.56,;1.9,-12.79,;.57,-13.56,;1.9,-11.25,;.57,-10.48,;.57,-1.24,;.57,.3,)| Show InChI InChI=1S/C21H32Cl2N4O/c1-25(2)21(28)24-17-8-6-16(7-9-17)10-11-26-12-14-27(15-13-26)19-5-3-4-18(22)20(19)23/h3-5,16-17H,6-15H2,1-2H3,(H,24,28)/t16-,17- | PDB
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Similars
| DrugBank Article PubMed
| 0.501 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.ejmech.2022.114193 BindingDB Entry DOI: 10.7270/Q2WS8Z8T |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 7
(Homo sapiens (Human)) | BDBM50253281
(CHEMBL522691 | N-(4-Cyanophenylmethyl)-4-(2-diphen...)Show SMILES O=C(CCCCCN1CCN(CC1)c1ccccc1-c1ccccc1)NCc1ccc(cc1)C#N Show InChI InChI=1S/C30H34N4O/c31-23-25-14-16-26(17-15-25)24-32-30(35)13-5-2-8-18-33-19-21-34(22-20-33)29-12-7-6-11-28(29)27-9-3-1-4-10-27/h1,3-4,6-7,9-12,14-17H,2,5,8,13,18-22,24H2,(H,32,35) | PDB
Reactome pathway KEGG
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CHEMBL MCE PC cid PC sid UniChem
Similars
| Article PubMed
| 0.580 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Jagiellonian University Medical College
Curated by ChEMBL
| Assay Description Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting |
Eur J Med Chem 78: 10-22 (2014)
Article DOI: 10.1016/j.ejmech.2014.03.005 BindingDB Entry DOI: 10.7270/Q2QN6899 |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 7
(Homo sapiens (Human)) | BDBM50253281
(CHEMBL522691 | N-(4-Cyanophenylmethyl)-4-(2-diphen...)Show SMILES O=C(CCCCCN1CCN(CC1)c1ccccc1-c1ccccc1)NCc1ccc(cc1)C#N Show InChI InChI=1S/C30H34N4O/c31-23-25-14-16-26(17-15-25)24-32-30(35)13-5-2-8-18-33-19-21-34(22-20-33)29-12-7-6-11-28(29)27-9-3-1-4-10-27/h1,3-4,6-7,9-12,14-17H,2,5,8,13,18-22,24H2,(H,32,35) | PDB
Reactome pathway KEGG
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DrugBank antibodypedia GoogleScholar AffyNet
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CHEMBL MCE PC cid PC sid UniChem
Similars
| Article PubMed
| 0.580 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr |
Eur J Med Chem 56: 348-360 (2012)
Article DOI: 10.1016/j.ejmech.2012.07.043 BindingDB Entry DOI: 10.7270/Q28P61N6 |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 1A
(Homo sapiens (Human)) | BDBM50004518
(CHEMBL2079256)Show SMILES COc1ccccc1N1CCN(CCCCN2C(=O)N(C)C(=O)C2(c2ccccc2)c2ccccc2)CC1 Show InChI InChI=1S/C31H36N4O3/c1-32-29(36)31(25-13-5-3-6-14-25,26-15-7-4-8-16-26)35(30(32)37)20-12-11-19-33-21-23-34(24-22-33)27-17-9-10-18-28(27)38-2/h3-10,13-18H,11-12,19-24H2,1-2H3 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 0.800 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Jagiellonian University Medical College
Curated by ChEMBL
| Assay Description Displacement of [3H]-8-OH-DPAT from human recombinant 5-HT1A receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation countin... |
Eur J Med Chem 78: 324-39 (2014)
Article DOI: 10.1016/j.ejmech.2014.01.065 BindingDB Entry DOI: 10.7270/Q2J104Q0 |
More data for this Ligand-Target Pair | |
D(2) dopamine receptor
(Homo sapiens (Human)) | BDBM50130293
(7-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy}...)Show SMILES Clc1cccc(N2CCN(CCCCOc3ccc4CCC(=O)Nc4c3)CC2)c1Cl Show InChI InChI=1S/C23H27Cl2N3O2/c24-19-4-3-5-21(23(19)25)28-13-11-27(12-14-28)10-1-2-15-30-18-8-6-17-7-9-22(29)26-20(17)16-18/h3-6,8,16H,1-2,7,9-15H2,(H,26,29) | PDB
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CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem
Patents
Similars
| DrugBank Article PubMed
| 0.800 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Jagiellonian University Medical College
Curated by ChEMBL
| Assay Description Displacement of [3H]-raclopride from human dopamine D2L receptor expressed in HEK293 after 1 hr |
Eur J Med Chem 60: 42-50 (2013)
Article DOI: 10.1016/j.ejmech.2012.11.042 BindingDB Entry DOI: 10.7270/Q21V5G98 |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 1A
(Homo sapiens (Human)) | BDBM152784
(1-[(2,4,6-trimethylphenoxy)propyl]-4-(2-methoxyphe...)Show InChI InChI=1S/C23H32N2O2.ClH/c1-18-16-19(2)23(20(3)17-18)27-15-7-10-24-11-13-25(14-12-24)21-8-5-6-9-22(21)26-4;/h5-6,8-9,16-17H,7,10-15H2,1-4H3;1H | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| <1 | <-51.4 | n/a | n/a | n/a | n/a | n/a | n/a | 25 |
Jagiellonian University Medical College
| Assay Description The composition of the assay buffers was as follows: for 5-HT1AR: 50 mM Tris¿HCl, 0.1 mM EDTA, 4 mM MgCl2, 10 lM pargyline, and 0.1% ascorbate; for 5... |
Chem Biol Drug Des 85: 326-35 (2015)
Article DOI: 10.1111/cbdd.12394 BindingDB Entry DOI: 10.7270/Q2DN43SZ |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 1A
(Homo sapiens (Human)) | BDBM152782
(1-[(2,5-dimethylphenoxy)propyl]-4-(2-methoxyphenyl...)Show InChI InChI=1S/C22H30N2O2.ClH/c1-18-9-10-19(2)22(17-18)26-16-6-11-23-12-14-24(15-13-23)20-7-4-5-8-21(20)25-3;/h4-5,7-10,17H,6,11-16H2,1-3H3;1H | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| <1 | <-51.4 | n/a | n/a | n/a | n/a | n/a | n/a | 25 |
Jagiellonian University Medical College
| Assay Description The composition of the assay buffers was as follows: for 5-HT1AR: 50 mM Tris¿HCl, 0.1 mM EDTA, 4 mM MgCl2, 10 lM pargyline, and 0.1% ascorbate; for 5... |
Chem Biol Drug Des 85: 326-35 (2015)
Article DOI: 10.1111/cbdd.12394 BindingDB Entry DOI: 10.7270/Q2DN43SZ |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 6
(Homo sapiens (Human)) | BDBM50232666
(CHEMBL4083059)Show SMILES CN(C)Cc1cc2cn(c3cccc(o1)c23)S(=O)(=O)c1cccc2ccccc12 Show InChI InChI=1S/C23H20N2O3S/c1-24(2)15-18-13-17-14-25(20-10-6-11-21(28-18)23(17)20)29(26,27)22-12-5-8-16-7-3-4-9-19(16)22/h3-14H,15H2,1-2H3 | PDB
Reactome pathway KEGG
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| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Polish Academy of Sciences
Curated by ChEMBL
| Assay Description Displacement of [3H]-LSD from 5-HT6 receptor (unknown origin) |
ACS Med Chem Lett 8: 390-394 (2017)
Article DOI: 10.1021/acsmedchemlett.6b00482 BindingDB Entry DOI: 10.7270/Q2DN479B |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 7
(Homo sapiens (Human)) | BDBM50143280
(CHEMBL3759205)Show SMILES CC(C)c1cccc(OCCN2C3CCC2CC(C3)NS(=O)(=O)c2ccc(F)cc2)c1 Show InChI InChI=1S/C24H31FN2O3S/c1-17(2)18-4-3-5-23(14-18)30-13-12-27-21-8-9-22(27)16-20(15-21)26-31(28,29)24-10-6-19(25)7-11-24/h3-7,10-11,14,17,20-22,26H,8-9,12-13,15-16H2,1-2H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Jagiellonian University Medical College
Curated by ChEMBL
| Assay Description Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr |
Eur J Med Chem 108: 334-46 (2016)
Article DOI: 10.1016/j.ejmech.2015.11.040 BindingDB Entry DOI: 10.7270/Q28S4RRH |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 1A
(Rattus norvegicus (rat)) | BDBM50083369
(CHEMBL3423339)Show SMILES Cc1cn2c(nc3n(C)c(=O)n(C)c(=O)c23)n1CCCCN1CCN(CC1)c1cccc(C)c1C Show InChI InChI=1S/C26H35N7O2/c1-18-9-8-10-21(20(18)3)31-15-13-30(14-16-31)11-6-7-12-32-19(2)17-33-22-23(27-25(32)33)28(4)26(35)29(5)24(22)34/h8-10,17H,6-7,11-16H2,1-5H3 | PDB
KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| <1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Jagiellonian University Medical College
Curated by ChEMBL
| Assay Description Displacement of [3H]8-OH-DPAT from rat hippocampus 5-HT1A receptor incubated for 20 mins by microbeta plate reader based method |
Eur J Med Chem 97: 142-54 (2015)
Article DOI: 10.1016/j.ejmech.2015.04.046 BindingDB Entry DOI: 10.7270/Q2TQ637Z |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 1A
(Homo sapiens (Human)) | BDBM50003915
(CHEMBL3235744)Show SMILES CSc1ccccc1N1CCN(CCCCCC(=O)N2Cc3ccccc3C[C@H]2C(N)=O)CC1 |r| Show InChI InChI=1S/C27H36N4O2S/c1-34-25-12-7-6-11-23(25)30-17-15-29(16-18-30)14-8-2-3-13-26(32)31-20-22-10-5-4-9-21(22)19-24(31)27(28)33/h4-7,9-12,24H,2-3,8,13-20H2,1H3,(H2,28,33)/t24-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| <1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Jagiellonian University Medical College
Curated by ChEMBL
| Assay Description Displacement of [3H]-8-OH-DPAT from human 5HT1A receptor expressed in HEK293 cells after 1 hr |
Eur J Med Chem 92: 202-11 (2015)
Article DOI: 10.1016/j.ejmech.2014.12.041 BindingDB Entry DOI: 10.7270/Q2TT4SNW |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 1A
(Homo sapiens (Human)) | BDBM152786
(1-[(2-chloro-6-methylphenoxy)ethoxyethyl]-4-(2-met...)Show InChI InChI=1S/C22H29ClN2O3.ClH/c1-18-6-5-7-19(23)22(18)28-17-16-27-15-14-24-10-12-25(13-11-24)20-8-3-4-9-21(20)26-2;/h3-9H,10-17H2,1-2H3;1H | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| <1 | <-51.4 | n/a | n/a | n/a | n/a | n/a | n/a | 25 |
Jagiellonian University Medical College
| Assay Description The composition of the assay buffers was as follows: for 5-HT1AR: 50 mM Tris¿HCl, 0.1 mM EDTA, 4 mM MgCl2, 10 lM pargyline, and 0.1% ascorbate; for 5... |
Chem Biol Drug Des 85: 326-35 (2015)
Article DOI: 10.1111/cbdd.12394 BindingDB Entry DOI: 10.7270/Q2DN43SZ |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 1A
(Rattus norvegicus (rat)) | BDBM50034793
(CHEMBL3360996)Show SMILES Cl.Cn1c2ncn(CCCCN3CCN(CC3)c3cccc(Cl)c3)c2c(=O)n(C)c1=O Show InChI InChI=1S/C21H27ClN6O2.ClH/c1-24-19-18(20(29)25(2)21(24)30)28(15-23-19)9-4-3-8-26-10-12-27(13-11-26)17-7-5-6-16(22)14-17;/h5-7,14-15H,3-4,8-13H2,1-2H3;1H | PDB
KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Jagiellonian University Medical College
Curated by ChEMBL
| Assay Description Displacement of [3H]-8-OH-DPAT from 5-HT1AR in rat hippocampus |
Bioorg Med Chem 23: 212-21 (2014)
Article DOI: 10.1016/j.bmc.2014.11.008 BindingDB Entry DOI: 10.7270/Q2WD425D |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 1A
(Rattus norvegicus (rat)) | BDBM50034797
(CHEMBL3361000)Show SMILES Cl.COc1ccccc1N1CCN(CCCCCn2cnc3n(C)c(=O)n(C)c(=O)c23)CC1 Show InChI InChI=1S/C23H32N6O3.ClH/c1-25-21-20(22(30)26(2)23(25)31)29(17-24-21)12-8-4-7-11-27-13-15-28(16-14-27)18-9-5-6-10-19(18)32-3;/h5-6,9-10,17H,4,7-8,11-16H2,1-3H3;1H | PDB
KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Jagiellonian University Medical College
Curated by ChEMBL
| Assay Description Displacement of [3H]-8-OH-DPAT from 5-HT1AR in rat hippocampus |
Bioorg Med Chem 23: 212-21 (2014)
Article DOI: 10.1016/j.bmc.2014.11.008 BindingDB Entry DOI: 10.7270/Q2WD425D |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 1A
(Homo sapiens (Human)) | BDBM50070614
(CHEMBL3409037)Show SMILES CC(C)c1ccccc1N1CCN(CCCCCCC(=O)N2CCC[C@H]2C(=O)N2CCCCC2)CC1 |r| Show InChI InChI=1S/C30H48N4O2/c1-25(2)26-13-7-8-14-27(26)32-23-21-31(22-24-32)17-9-4-3-6-16-29(35)34-20-12-15-28(34)30(36)33-18-10-5-11-19-33/h7-8,13-14,25,28H,3-6,9-12,15-24H2,1-2H3/t28-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Jagiellonian University Medical College
Curated by ChEMBL
| Assay Description Displacement of [3H]-8-OH-DPAT from human 5HT1A receptor expressed in HEK293 cells after 1 hr |
Eur J Med Chem 92: 202-11 (2015)
Article DOI: 10.1016/j.ejmech.2014.12.041 BindingDB Entry DOI: 10.7270/Q2TT4SNW |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 1A
(Homo sapiens (Human)) | BDBM50003915
(CHEMBL3235744)Show SMILES CSc1ccccc1N1CCN(CCCCCC(=O)N2Cc3ccccc3C[C@H]2C(N)=O)CC1 |r| Show InChI InChI=1S/C27H36N4O2S/c1-34-25-12-7-6-11-23(25)30-17-15-29(16-18-30)14-8-2-3-13-26(32)31-20-22-10-5-4-9-21(22)19-24(31)27(28)33/h4-7,9-12,24H,2-3,8,13-20H2,1H3,(H2,28,33)/t24-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| <1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Jagiellonian University Medical College
Curated by ChEMBL
| Assay Description Displacement of [3H]-8-OH-DPAT from human 5-HT1A receptor expressed in HEK293 cells after 1 hr by beta-counting |
Eur J Med Chem 78: 10-22 (2014)
Article DOI: 10.1016/j.ejmech.2014.03.005 BindingDB Entry DOI: 10.7270/Q2QN6899 |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 7
(Homo sapiens (Human)) | BDBM50098551
((R)-3-(2-(2-(4-methylpiperidin-1-yl)ethyl)pyrrolid...)Show SMILES CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2cccc(O)c2)CC1 |r| Show InChI InChI=1S/C18H28N2O3S/c1-15-7-11-19(12-8-15)13-9-16-4-3-10-20(16)24(22,23)18-6-2-5-17(21)14-18/h2,5-6,14-16,21H,3-4,7-13H2,1H3/t16-/m1/s1 | PDB
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| Article PubMed
| 1.20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Jagiellonian University Medical College
Curated by ChEMBL
| Assay Description Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting |
Bioorg Med Chem 19: 6750-9 (2011)
Article DOI: 10.1016/j.bmc.2011.09.044 BindingDB Entry DOI: 10.7270/Q2028S0V |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 7
(Homo sapiens (Human)) | BDBM50098551
((R)-3-(2-(2-(4-methylpiperidin-1-yl)ethyl)pyrrolid...)Show SMILES CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2cccc(O)c2)CC1 |r| Show InChI InChI=1S/C18H28N2O3S/c1-15-7-11-19(12-8-15)13-9-16-4-3-10-20(16)24(22,23)18-6-2-5-17(21)14-18/h2,5-6,14-16,21H,3-4,7-13H2,1H3/t16-/m1/s1 | PDB
Reactome pathway KEGG
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| Article PubMed
| 1.20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr |
Eur J Med Chem 56: 348-360 (2012)
Article DOI: 10.1016/j.ejmech.2012.07.043 BindingDB Entry DOI: 10.7270/Q28P61N6 |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 1A
(Rattus norvegicus (rat)) | BDBM50034792
(CHEMBL3360995)Show SMILES Cl.COc1ccccc1N1CCN(CCCCn2cnc3n(C)c(=O)n(C)c(=O)c23)CC1 Show InChI InChI=1S/C22H30N6O3.ClH/c1-24-20-19(21(29)25(2)22(24)30)28(16-23-20)11-7-6-10-26-12-14-27(15-13-26)17-8-4-5-9-18(17)31-3;/h4-5,8-9,16H,6-7,10-15H2,1-3H3;1H | PDB
KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 1.20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Jagiellonian University Medical College
Curated by ChEMBL
| Assay Description Displacement of [3H]-8-OH-DPAT from 5-HT1AR in rat hippocampus |
Bioorg Med Chem 23: 212-21 (2014)
Article DOI: 10.1016/j.bmc.2014.11.008 BindingDB Entry DOI: 10.7270/Q2WD425D |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 1A
(Rattus norvegicus (rat)) | BDBM50083500
(CHEMBL3423328)Show SMILES Cn1c2nc3n(CCCCN4CCN(CC4)c4ccccc4O)ccn3c2c(=O)n(C)c1=O Show InChI InChI=1S/C23H29N7O3/c1-25-20-19(21(32)26(2)23(25)33)30-16-15-29(22(30)24-20)10-6-5-9-27-11-13-28(14-12-27)17-7-3-4-8-18(17)31/h3-4,7-8,15-16,31H,5-6,9-14H2,1-2H3 | PDB
KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 2 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Jagiellonian University Medical College
Curated by ChEMBL
| Assay Description Displacement of [3H]8-OH-DPAT from rat hippocampus 5-HT1A receptor incubated for 20 mins by microbeta plate reader based method |
Eur J Med Chem 97: 142-54 (2015)
Article DOI: 10.1016/j.ejmech.2015.04.046 BindingDB Entry DOI: 10.7270/Q2TQ637Z |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 7
(Homo sapiens (Human)) | BDBM50393395
(CHEMBL2159489)Show SMILES Fc1ccc(cc1)S(=O)(=O)N[C@@H]1CCN(CCOc2ccccc2-c2ccccc2)C1 |r| Show InChI InChI=1S/C24H25FN2O3S/c25-20-10-12-22(13-11-20)31(28,29)26-21-14-15-27(18-21)16-17-30-24-9-5-4-8-23(24)19-6-2-1-3-7-19/h1-13,21,26H,14-18H2/t21-/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
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Similars
| Article PubMed
| 2 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr |
Eur J Med Chem 56: 348-360 (2012)
Article DOI: 10.1016/j.ejmech.2012.07.043 BindingDB Entry DOI: 10.7270/Q28P61N6 |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 7
(Homo sapiens (Human)) | BDBM50143372
(CHEMBL3759617)Show SMILES CC(C)c1cccc(OCCN2C3CCC2CC(C3)NS(=O)(=O)c2cccc(F)c2)c1 Show InChI InChI=1S/C24H31FN2O3S/c1-17(2)18-5-3-7-23(13-18)30-12-11-27-21-9-10-22(27)16-20(15-21)26-31(28,29)24-8-4-6-19(25)14-24/h3-8,13-14,17,20-22,26H,9-12,15-16H2,1-2H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 2 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Jagiellonian University Medical College
Curated by ChEMBL
| Assay Description Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr |
Eur J Med Chem 108: 334-46 (2016)
Article DOI: 10.1016/j.ejmech.2015.11.040 BindingDB Entry DOI: 10.7270/Q28S4RRH |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 1A
(Homo sapiens (Human)) | BDBM50003916
(CHEMBL3235745)Show SMILES CSc1ccccc1N1CCN(CCCCCCC(=O)N2Cc3ccccc3C[C@H]2C(N)=O)CC1 |r| Show InChI InChI=1S/C28H38N4O2S/c1-35-26-13-8-7-12-24(26)31-18-16-30(17-19-31)15-9-3-2-4-14-27(33)32-21-23-11-6-5-10-22(23)20-25(32)28(29)34/h5-8,10-13,25H,2-4,9,14-21H2,1H3,(H2,29,34)/t25-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 2 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Jagiellonian University Medical College
Curated by ChEMBL
| Assay Description Displacement of [3H]-8-OH-DPAT from human 5-HT1A receptor expressed in HEK293 cells after 1 hr by beta-counting |
Eur J Med Chem 78: 10-22 (2014)
Article DOI: 10.1016/j.ejmech.2014.03.005 BindingDB Entry DOI: 10.7270/Q2QN6899 |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 1A
(Rattus norvegicus (rat)) | BDBM50083360
(CHEMBL3423330)Show SMILES Cc1cn2c(nc3n(C)c(=O)n(C)c(=O)c23)n1CCCCN1CCN(CC1)c1ccccc1O Show InChI InChI=1S/C24H31N7O3/c1-17-16-31-20-21(26(2)24(34)27(3)22(20)33)25-23(31)30(17)11-7-6-10-28-12-14-29(15-13-28)18-8-4-5-9-19(18)32/h4-5,8-9,16,32H,6-7,10-15H2,1-3H3 | PDB
KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 2 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Jagiellonian University Medical College
Curated by ChEMBL
| Assay Description Displacement of [3H]8-OH-DPAT from rat hippocampus 5-HT1A receptor incubated for 20 mins by microbeta plate reader based method |
Eur J Med Chem 97: 142-54 (2015)
Article DOI: 10.1016/j.ejmech.2015.04.046 BindingDB Entry DOI: 10.7270/Q2TQ637Z |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 1A
(Rattus norvegicus (rat)) | BDBM50083497
(CHEMBL3423377)Show SMILES Cn1c2nc3n(CCCCCN4CCN(CC4)c4ccccc4O)c(=O)ccn3c2c(=O)n(C)c1=O Show InChI InChI=1S/C25H31N7O4/c1-27-22-21(23(35)28(2)25(27)36)32-13-10-20(34)31(24(32)26-22)12-7-3-6-11-29-14-16-30(17-15-29)18-8-4-5-9-19(18)33/h4-5,8-10,13,33H,3,6-7,11-12,14-17H2,1-2H3 | PDB
KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 2 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Jagiellonian University Medical College
Curated by ChEMBL
| Assay Description Displacement of [3H]8-OH-DPAT from rat hippocampus 5-HT1A receptor incubated for 20 mins by microbeta plate reader based method |
Eur J Med Chem 97: 142-54 (2015)
Article DOI: 10.1016/j.ejmech.2015.04.046 BindingDB Entry DOI: 10.7270/Q2TQ637Z |
More data for this Ligand-Target Pair | |
D(2) dopamine receptor
(Homo sapiens (Human)) | BDBM50048803
(5-(2-(4-(benzo[d]isothiazol-3-yl)piperazin-1-yl)et...)Show SMILES Clc1cc2NC(=O)Cc2cc1CCN1CCN(CC1)c1nsc2ccccc12 Show InChI InChI=1S/C21H21ClN4OS/c22-17-13-18-15(12-20(27)23-18)11-14(17)5-6-25-7-9-26(10-8-25)21-16-3-1-2-4-19(16)28-24-21/h1-4,11,13H,5-10,12H2,(H,23,27) | PDB
Reactome pathway KEGG
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CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem
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| DrugBank Article PubMed
| 2.10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Polish Academy of Sciences
Curated by ChEMBL
| Assay Description Displacement of [3H]-Raclopride from D2L receptor (unknown origin) |
ACS Med Chem Lett 8: 390-394 (2017)
Article DOI: 10.1021/acsmedchemlett.6b00482 BindingDB Entry DOI: 10.7270/Q2DN479B |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 7
(Homo sapiens (Human)) | BDBM50004756
(CHEMBL3233679)Show SMILES Cl.COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(C2=O)c2ccc(F)cc2)CC1 Show InChI InChI=1S/C24H29FN4O4.ClH/c1-24(17-7-9-18(25)10-8-17)22(31)29(23(32)26-24)16-19(30)15-27-11-13-28(14-12-27)20-5-3-4-6-21(20)33-2;/h3-10,19,30H,11-16H2,1-2H3,(H,26,32);1H | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Jagiellonian University Medical College
Curated by ChEMBL
| Assay Description Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting anal... |
Eur J Med Chem 78: 324-39 (2014)
Article DOI: 10.1016/j.ejmech.2014.01.065 BindingDB Entry DOI: 10.7270/Q2J104Q0 |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 1A
(Homo sapiens (Human)) | BDBM10755
(14C-5-hydroxy tryptamine creatinine disulfate | 2-...)Show InChI InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2 | PDB
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| 3 | -48.6 | n/a | n/a | n/a | n/a | n/a | n/a | 25 |
Jagiellonian University Medical College
| Assay Description The composition of the assay buffers was as follows: for 5-HT1AR: 50 mM Tris¿HCl, 0.1 mM EDTA, 4 mM MgCl2, 10 lM pargyline, and 0.1% ascorbate; for 5... |
Chem Biol Drug Des 85: 326-35 (2015)
Article DOI: 10.1111/cbdd.12394 BindingDB Entry DOI: 10.7270/Q2DN43SZ |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
5-hydroxytryptamine receptor 7
(Homo sapiens (Human)) | BDBM50130261
(6-(2-{2-[4-(4-Chloro-phenoxy)-piperidin-1-yl]-ethy...)Show SMILES Clc1ccc(OC2CCN(CC[C@H]3CCCN3S(=O)(=O)c3ccc4cc[nH]c4c3)CC2)cc1 Show InChI InChI=1S/C25H30ClN3O3S/c26-20-4-6-22(7-5-20)32-23-11-16-28(17-12-23)15-10-21-2-1-14-29(21)33(30,31)24-8-3-19-9-13-27-25(19)18-24/h3-9,13,18,21,23,27H,1-2,10-12,14-17H2/t21-/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 3.20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr |
Eur J Med Chem 56: 348-360 (2012)
Article DOI: 10.1016/j.ejmech.2012.07.043 BindingDB Entry DOI: 10.7270/Q28P61N6 |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 1A
(Rattus norvegicus (rat)) | BDBM50357975
(CHEMBL1917341)Show SMILES COc1ccccc1N1CCN(CCCCNS(=O)(=O)c2cnc3ccccc3c2)CC1 Show InChI InChI=1S/C24H30N4O3S/c1-31-24-11-5-4-10-23(24)28-16-14-27(15-17-28)13-7-6-12-26-32(29,30)21-18-20-8-2-3-9-22(20)25-19-21/h2-5,8-11,18-19,26H,6-7,12-17H2,1H3 | PDB
KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 3.70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Jagiellonian University Medical College
Curated by ChEMBL
| Assay Description Displacement of [3H]-8-OH-DPAT from 5-HT1A receptor in rat hippocampus by liquid scintillation counting |
Bioorg Med Chem 19: 6750-9 (2011)
Article DOI: 10.1016/j.bmc.2011.09.044 BindingDB Entry DOI: 10.7270/Q2028S0V |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 7
(Homo sapiens (Human)) | BDBM50393394
(CHEMBL2159488)Show SMILES Clc1ccc(s1)S(=O)(=O)N[C@@H]1CCN(CCOc2ccccc2-c2ccccc2)C1 |r| Show InChI InChI=1S/C22H23ClN2O3S2/c23-21-10-11-22(29-21)30(26,27)24-18-12-13-25(16-18)14-15-28-20-9-5-4-8-19(20)17-6-2-1-3-7-17/h1-11,18,24H,12-16H2/t18-/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr |
Eur J Med Chem 56: 348-360 (2012)
Article DOI: 10.1016/j.ejmech.2012.07.043 BindingDB Entry DOI: 10.7270/Q28P61N6 |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 1A
(Homo sapiens (Human)) | BDBM50003945
(CHEMBL3235739)Show SMILES NC(=O)[C@@H]1CCCN1C(=O)CCCCCN1CCN(CC1)c1cccc(Cl)c1Cl |r| Show InChI InChI=1S/C21H30Cl2N4O2/c22-16-6-4-7-17(20(16)23)26-14-12-25(13-15-26)10-3-1-2-9-19(28)27-11-5-8-18(27)21(24)29/h4,6-7,18H,1-3,5,8-15H2,(H2,24,29)/t18-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Jagiellonian University Medical College
Curated by ChEMBL
| Assay Description Displacement of [3H]-8-OH-DPAT from human 5-HT1A receptor expressed in HEK293 cells after 1 hr by beta-counting |
Eur J Med Chem 78: 10-22 (2014)
Article DOI: 10.1016/j.ejmech.2014.03.005 BindingDB Entry DOI: 10.7270/Q2QN6899 |
More data for this Ligand-Target Pair | |
D(2) dopamine receptor
(Homo sapiens (Human)) | BDBM50083362
(CHEMBL3423332)Show SMILES Cn1c2nc3n(CCCCN4CCN(CC4)c4ccccc4O)c(cn3c2c(=O)n(C)c1=O)-c1ccccc1 Show InChI InChI=1S/C29H33N7O3/c1-31-26-25(27(38)32(2)29(31)39)36-20-23(21-10-4-3-5-11-21)35(28(36)30-26)15-9-8-14-33-16-18-34(19-17-33)22-12-6-7-13-24(22)37/h3-7,10-13,20,37H,8-9,14-19H2,1-2H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Jagiellonian University Medical College
Curated by ChEMBL
| Assay Description Displacement of [3H]N-methylspiperone from human recombinant dopamine D2 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate r... |
Eur J Med Chem 97: 142-54 (2015)
Article DOI: 10.1016/j.ejmech.2015.04.046 BindingDB Entry DOI: 10.7270/Q2TQ637Z |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 7
(Homo sapiens (Human)) | BDBM50143373
(CHEMBL3758286)Show SMILES CC(C)c1cccc(OCCN2C3CCC2CC(C3)NS(=O)(=O)c2cccc(Cl)c2)c1 Show InChI InChI=1S/C24H31ClN2O3S/c1-17(2)18-5-3-7-23(13-18)30-12-11-27-21-9-10-22(27)16-20(15-21)26-31(28,29)24-8-4-6-19(25)14-24/h3-8,13-14,17,20-22,26H,9-12,15-16H2,1-2H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Jagiellonian University Medical College
Curated by ChEMBL
| Assay Description Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr |
Eur J Med Chem 108: 334-46 (2016)
Article DOI: 10.1016/j.ejmech.2015.11.040 BindingDB Entry DOI: 10.7270/Q28S4RRH |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 3A
(GUINEA PIG) | BDBM50000483
((BRL 43694)1-Methyl-1H-indazole-3-carboxylic acid ...)Show SMILES CN1C2CCCC1CC(C2)NC(=O)c1nn(C)c2ccccc12 |THB:10:8:1:3.5.4| Show InChI InChI=1S/C18H24N4O/c1-21-13-6-5-7-14(21)11-12(10-13)19-18(23)17-15-8-3-4-9-16(15)22(2)20-17/h3-4,8-9,12-14H,5-7,10-11H2,1-2H3,(H,19,23) | PDB
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| 4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.ejmech.2022.114193 BindingDB Entry DOI: 10.7270/Q2WS8Z8T |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 6
(Homo sapiens (Human)) | BDBM50232674
(CHEMBL4068850)Show SMILES OCc1cc2cn(c3cccc(o1)c23)S(=O)(=O)c1cccc2ccccc12 Show InChI InChI=1S/C21H15NO4S/c23-13-16-11-15-12-22(18-8-4-9-19(26-16)21(15)18)27(24,25)20-10-3-6-14-5-1-2-7-17(14)20/h1-12,23H,13H2 | PDB
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| CHEMBL PC cid PC sid UniChem
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| Article PubMed
| 4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Polish Academy of Sciences
Curated by ChEMBL
| Assay Description Displacement of [3H]-LSD from 5-HT6 receptor (unknown origin) |
ACS Med Chem Lett 8: 390-394 (2017)
Article DOI: 10.1021/acsmedchemlett.6b00482 BindingDB Entry DOI: 10.7270/Q2DN479B |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 7
(Homo sapiens (Human)) | BDBM50393391
(CHEMBL2159485)Show SMILES CC(C)c1ccccc1OCCN1CCC(C1)NS(=O)(=O)c1cccc(Cl)c1 Show InChI InChI=1S/C21H27ClN2O3S/c1-16(2)20-8-3-4-9-21(20)27-13-12-24-11-10-18(15-24)23-28(25,26)19-7-5-6-17(22)14-19/h3-9,14,16,18,23H,10-13,15H2,1-2H3 | PDB
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| CHEMBL PC cid PC sid UniChem
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| Article PubMed
| 4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr |
Eur J Med Chem 56: 348-360 (2012)
Article DOI: 10.1016/j.ejmech.2012.07.043 BindingDB Entry DOI: 10.7270/Q28P61N6 |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 6
(Homo sapiens (Human)) | BDBM22869
(6-chloro-10-(4-methylpiperazin-1-yl)-2,9-diazatric...)Show SMILES CN1CCN(CC1)C1=c2ccccc2=Nc2ccc(Cl)cc2N1 |c:8,15| Show InChI InChI=1S/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,21H,8-11H2,1H3 | PDB
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| 4 | -47.9 | n/a | n/a | n/a | n/a | n/a | n/a | 25 |
Jagiellonian University Medical College
| Assay Description The composition of the assay buffers was as follows: for 5-HT1AR: 50 mM Tris¿HCl, 0.1 mM EDTA, 4 mM MgCl2, 10 lM pargyline, and 0.1% ascorbate; for 5... |
Chem Biol Drug Des 85: 326-35 (2015)
Article DOI: 10.1111/cbdd.12394 BindingDB Entry DOI: 10.7270/Q2DN43SZ |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 6
(Homo sapiens (Human)) | BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)Show SMILES CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2ccccc12 |t:8| Show InChI InChI=1S/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,20H,8-11H2,1H3 | PDB
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| 4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Displacement of [3H]-LSD from human 5-HT6 receptor expressed in HEK293 cells after 1 hr |
Eur J Med Chem 56: 348-360 (2012)
Article DOI: 10.1016/j.ejmech.2012.07.043 BindingDB Entry DOI: 10.7270/Q28P61N6 |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 7
(Homo sapiens (Human)) | BDBM50143370
(CHEMBL3759233)Show SMILES CC(C)c1cccc(OCCN2C3CCC2CC(C3)NS(=O)(=O)c2cc(F)ccc2F)c1 Show InChI InChI=1S/C24H30F2N2O3S/c1-16(2)17-4-3-5-22(12-17)31-11-10-28-20-7-8-21(28)15-19(14-20)27-32(29,30)24-13-18(25)6-9-23(24)26/h3-6,9,12-13,16,19-21,27H,7-8,10-11,14-15H2,1-2H3 | PDB
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| CHEMBL PC cid PC sid UniChem
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| 4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Jagiellonian University Medical College
Curated by ChEMBL
| Assay Description Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr |
Eur J Med Chem 108: 334-46 (2016)
Article DOI: 10.1016/j.ejmech.2015.11.040 BindingDB Entry DOI: 10.7270/Q28S4RRH |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 7
(Homo sapiens (Human)) | BDBM50193430
(CHEMBL3985152)Show SMILES COCOc1ccc(CNC(=O)CCCCCN2CCN(CC2)c2ccccc2-c2ccccc2)cc1 Show InChI InChI=1S/C31H39N3O3/c1-36-25-37-28-17-15-26(16-18-28)24-32-31(35)14-6-3-9-19-33-20-22-34(23-21-33)30-13-8-7-12-29(30)27-10-4-2-5-11-27/h2,4-5,7-8,10-13,15-18H,3,6,9,14,19-25H2,1H3,(H,32,35) | PDB
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| CHEMBL PC cid PC sid UniChem
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| Article PubMed
| 4.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Bari"A. Moro"
Curated by ChEMBL
| Assay Description Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis |
Eur J Med Chem 120: 363-79 (2016)
Article DOI: 10.1016/j.ejmech.2016.05.005 BindingDB Entry DOI: 10.7270/Q25T3NF8 |
More data for this Ligand-Target Pair | |
D(2) dopamine receptor
(Homo sapiens (Human)) | BDBM50130293
(7-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy}...)Show SMILES Clc1cccc(N2CCN(CCCCOc3ccc4CCC(=O)Nc4c3)CC2)c1Cl Show InChI InChI=1S/C23H27Cl2N3O2/c24-19-4-3-5-21(23(19)25)28-13-11-27(12-14-28)10-1-2-15-30-18-8-6-17-7-9-22(29)26-20(17)16-18/h3-6,8,16H,1-2,7,9-15H2,(H,26,29) | PDB
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| 4.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.ejmech.2022.114193 BindingDB Entry DOI: 10.7270/Q2WS8Z8T |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 7
(Homo sapiens (Human)) | BDBM50496111
(CHEMBL3121424)Show SMILES OC(=O)\C=C\C(O)=O.COc1ccccc1N1CCN(Cc2cn(-c3cccc4ccccc34)c3ccccc23)CC1 Show InChI InChI=1S/C30H29N3O/c1-34-30-16-7-6-14-29(30)32-19-17-31(18-20-32)21-24-22-33(27-13-5-4-12-26(24)27)28-15-8-10-23-9-2-3-11-25(23)28/h2-16,22H,17-21H2,1H3 | PDB
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| PC cid PC sid UniChem
| Article PubMed
| 4.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ de Lyon
Curated by ChEMBL
| Assay Description Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting |
Eur J Med Chem 75: 159-68 (2014)
Article DOI: 10.1016/j.ejmech.2014.01.055 BindingDB Entry DOI: 10.7270/Q24J0J3B |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 2A
(Rattus norvegicus (rat)) | BDBM35254
(2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3...)Show InChI InChI=1S/C17H20N4S/c1-12-11-13-16(21-9-7-20(2)8-10-21)18-14-5-3-4-6-15(14)19-17(13)22-12/h3-6,11,19H,7-10H2,1-2H3 | PDB
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| 4.60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Jagiellonian University Medical College
Curated by ChEMBL
| Assay Description Displacement of [3H]-ketanserin from 5-HT2AR in rat cortex |
Bioorg Med Chem 23: 212-21 (2014)
Article DOI: 10.1016/j.bmc.2014.11.008 BindingDB Entry DOI: 10.7270/Q2WD425D |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 6
(Homo sapiens (Human)) | BDBM35254
(2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3...)Show InChI InChI=1S/C17H20N4S/c1-12-11-13-16(21-9-7-20(2)8-10-21)18-14-5-3-4-6-15(14)19-17(13)22-12/h3-6,11,19H,7-10H2,1-2H3 | PDB
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| 5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Displacement of [3H]-LSD from human 5-HT6 receptor expressed in HEK293 cells after 1 hr |
Eur J Med Chem 56: 348-360 (2012)
Article DOI: 10.1016/j.ejmech.2012.07.043 BindingDB Entry DOI: 10.7270/Q28P61N6 |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 1A
(Homo sapiens (Human)) | BDBM163719
(3-Cyclohexyl-5-{4-[4-(2-methoxyphenyl)piperazin-1-...)Show SMILES COc1ccccc1N1CCN(CCCCC2NC(=NNC2=O)C2CCCCC2)CC1 |c:19| Show InChI InChI=1S/C24H37N5O2/c1-31-22-13-6-5-12-21(22)29-17-15-28(16-18-29)14-8-7-11-20-24(30)27-26-23(25-20)19-9-3-2-4-10-19/h5-6,12-13,19-20H,2-4,7-11,14-18H2,1H3,(H,25,26)(H,27,30) | PDB
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| 5 | -47.4 | n/a | n/a | n/a | n/a | n/a | n/a | 25 |
Jagiellonian University Medical College
| Assay Description All assays were incubated in a total volume of 200 mL in 96-well microtiter plates for 1 h at 37 °C, except for 5-HT1ARs which were incubated at room... |
Chem Biol Drug Des 86: 697-703 (2015)
Article DOI: 10.1111/cbdd.12539 BindingDB Entry DOI: 10.7270/Q2DR2T86 |
More data for this Ligand-Target Pair | |