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Compile Data Set for Download or QSAR

Found 523 hits with Last Name = 'sawyer' and Initial = 'j'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Leukotriene B4 receptor 1


(Homo sapiens (Human))		BDBM50029464
PNG
(5-(2-Carboxy-ethyl)-6-[3-(5-ethyl-4'-fluoro-2-hydr...)
Show SMILES CCc1cc(c(O)cc1OCCCOc1ccc2c(oc3ccc(cc3c2=O)C(O)=O)c1CCC(O)=O)-c1ccc(F)cc1
Show InChI InChI=1S/C34H29FO9/c1-2-19-16-25(20-4-7-22(35)8-5-20)27(36)18-30(19)43-15-3-14-42-28-12-9-24-32(39)26-17-21(34(40)41)6-11-29(26)44-33(24)23(28)10-13-31(37)38/h4-9,11-12,16-18,36H,2-3,10,13-15H2,1H3,(H,37,38)(H,40,41)
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 0.0400n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
LTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]-LTB4 in guinea pig lung membranes

Bioorg Med Chem Lett 4: 2077-2082 (1994)


Article DOI: 10.1016/S0960-894X(01)80105-0
BindingDB Entry DOI: 10.7270/Q27D2V2X
More data for this
Ligand-Target Pair
Leukotriene B4 receptor 1


(Homo sapiens (Human))		BDBM50029464
PNG
(5-(2-Carboxy-ethyl)-6-[3-(5-ethyl-4'-fluoro-2-hydr...)
Show SMILES CCc1cc(c(O)cc1OCCCOc1ccc2c(oc3ccc(cc3c2=O)C(O)=O)c1CCC(O)=O)-c1ccc(F)cc1
Show InChI InChI=1S/C34H29FO9/c1-2-19-16-25(20-4-7-22(35)8-5-20)27(36)18-30(19)43-15-3-14-42-28-12-9-24-32(39)26-17-21(34(40)41)6-11-29(26)44-33(24)23(28)10-13-31(37)38/h4-9,11-12,16-18,36H,2-3,10,13-15H2,1H3,(H,37,38)(H,40,41)
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 0.0400n/an/an/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Tested for inhibition of specific binding of [3H]LTB4 to guinea pig lung membranes expressing LTB4 receptor

J Med Chem 36: 3982-4 (1994)


BindingDB Entry DOI: 10.7270/Q2H1313H
More data for this
Ligand-Target Pair
Leukotriene B4 receptor 1


(Homo sapiens (Human))		BDBM50283055
PNG
(5-{3-(2-Carboxy-ethyl)-4-[3-(5-ethyl-4'-fluoro-2-h...)
Show SMILES CCc1cc(c(O)cc1OCCCOc1ccc(cc1CCC(O)=O)C#CCCC(O)=O)-c1ccc(F)cc1
Show InChI InChI=1S/C31H31FO7/c1-2-22-19-26(23-9-12-25(32)13-10-23)27(33)20-29(22)39-17-5-16-38-28-14-8-21(6-3-4-7-30(34)35)18-24(28)11-15-31(36)37/h8-10,12-14,18-20,33H,2,4-5,7,11,15-17H2,1H3,(H,34,35)(H,36,37)
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 0.0730n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
LTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]-LTB4 in human neutrophil

Bioorg Med Chem Lett 4: 2077-2082 (1994)


Article DOI: 10.1016/S0960-894X(01)80105-0
BindingDB Entry DOI: 10.7270/Q27D2V2X
More data for this
Ligand-Target Pair
Leukotriene B4 receptor 1


(Homo sapiens (Human))		BDBM50283055
PNG
(5-{3-(2-Carboxy-ethyl)-4-[3-(5-ethyl-4'-fluoro-2-h...)
Show SMILES CCc1cc(c(O)cc1OCCCOc1ccc(cc1CCC(O)=O)C#CCCC(O)=O)-c1ccc(F)cc1
Show InChI InChI=1S/C31H31FO7/c1-2-22-19-26(23-9-12-25(32)13-10-23)27(33)20-29(22)39-17-5-16-38-28-14-8-21(6-3-4-7-30(34)35)18-24(28)11-15-31(36)37/h8-10,12-14,18-20,33H,2,4-5,7,11,15-17H2,1H3,(H,34,35)(H,36,37)
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 0.0730n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
LTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]-LTB4 in guinea pig lung membranes

Bioorg Med Chem Lett 4: 2077-2082 (1994)


Article DOI: 10.1016/S0960-894X(01)80105-0
BindingDB Entry DOI: 10.7270/Q27D2V2X
More data for this
Ligand-Target Pair
Leukotriene B4 receptor 1


(Homo sapiens (Human))		BDBM50029477
PNG
(5-(2-Carboxy-ethyl)-6-[3-(5-ethyl-2-hydroxy-biphen...)
Show SMILES CCc1cc(c(O)cc1OCCCOc1ccc2c(oc3ccc(cc3c2=O)C(O)=O)c1CCC(O)=O)-c1ccccc1
Show InChI InChI=1S/C34H30O9/c1-2-20-17-25(21-7-4-3-5-8-21)27(35)19-30(20)42-16-6-15-41-28-13-10-24-32(38)26-18-22(34(39)40)9-12-29(26)43-33(24)23(28)11-14-31(36)37/h3-5,7-10,12-13,17-19,35H,2,6,11,14-16H2,1H3,(H,36,37)(H,39,40)
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 0.110n/an/an/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Tested for inhibition of specific binding of [3H]-LTB4 to guinea pig lung membranes expressing LTB4 receptor

J Med Chem 36: 3982-4 (1994)


BindingDB Entry DOI: 10.7270/Q2H1313H
More data for this
Ligand-Target Pair
Leukotriene B4 receptor 1


(Homo sapiens (Human))		BDBM50013889
PNG
((5S,6Z,8E,10E,12R,14Z)-5,12-dihydroxyicosa-6,8,10,...)
Show SMILES CCCCC\C=C/C[C@@H](O)\C=C\C=C\C=C/[C@@H](O)CCCC(O)=O |r|
Show InChI InChI=1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/b8-7+,9-6-,14-10+,15-11-/t18-,19-/m1/s1
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 0.120n/an/an/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Tested for inhibition of specific binding of [3H]LTB4 to guinea pig lung membranes expressing LTB4 receptor

J Med Chem 36: 3982-4 (1994)


BindingDB Entry DOI: 10.7270/Q2H1313H
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Leukotriene B4 receptor 1


(Homo sapiens (Human))		BDBM50013889
PNG
((5S,6Z,8E,10E,12R,14Z)-5,12-dihydroxyicosa-6,8,10,...)
Show SMILES CCCCC\C=C/C[C@@H](O)\C=C\C=C\C=C/[C@@H](O)CCCC(O)=O |r|
Show InChI InChI=1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/b8-7+,9-6-,14-10+,15-11-/t18-,19-/m1/s1
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 0.120n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
LTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]-LTB4 in guinea pig lung membranes

Bioorg Med Chem Lett 4: 2077-2082 (1994)


Article DOI: 10.1016/S0960-894X(01)80105-0
BindingDB Entry DOI: 10.7270/Q27D2V2X
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Leukotriene B4 receptor 1


(Homo sapiens (Human))		BDBM50013889
PNG
((5S,6Z,8E,10E,12R,14Z)-5,12-dihydroxyicosa-6,8,10,...)
Show SMILES CCCCC\C=C/C[C@@H](O)\C=C\C=C\C=C/[C@@H](O)CCCC(O)=O |r|
Show InChI InChI=1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/b8-7+,9-6-,14-10+,15-11-/t18-,19-/m1/s1
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 0.120n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranes

Bioorg Med Chem Lett 3: 1981-1984 (1993)


Article DOI: 10.1016/S0960-894X(01)80999-9
BindingDB Entry DOI: 10.7270/Q2VH5P9R
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Leukotriene B4 receptor 1


(Homo sapiens (Human))		BDBM50283054
PNG
(4-{2-(2-Carboxy-ethyl)-3-[3-(5-ethyl-4'-fluoro-2-h...)
Show SMILES CCc1cc(c(O)cc1OCCCOc1cccc(Oc2ccc(cc2)C(O)=O)c1CCC(O)=O)-c1ccc(F)cc1
Show InChI InChI=1S/C33H31FO8/c1-2-21-19-27(22-7-11-24(34)12-8-22)28(35)20-31(21)41-18-4-17-40-29-5-3-6-30(26(29)15-16-32(36)37)42-25-13-9-23(10-14-25)33(38)39/h3,5-14,19-20,35H,2,4,15-18H2,1H3,(H,36,37)(H,38,39)
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 0.140n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
LTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]-LTB4 in human neutrophil

Bioorg Med Chem Lett 4: 2077-2082 (1994)


Article DOI: 10.1016/S0960-894X(01)80105-0
BindingDB Entry DOI: 10.7270/Q27D2V2X
More data for this
Ligand-Target Pair
Leukotriene B4 receptor 1


(Homo sapiens (Human))		BDBM50029464
PNG
(5-(2-Carboxy-ethyl)-6-[3-(5-ethyl-4'-fluoro-2-hydr...)
Show SMILES CCc1cc(c(O)cc1OCCCOc1ccc2c(oc3ccc(cc3c2=O)C(O)=O)c1CCC(O)=O)-c1ccc(F)cc1
Show InChI InChI=1S/C34H29FO9/c1-2-19-16-25(20-4-7-22(35)8-5-20)27(36)18-30(19)43-15-3-14-42-28-12-9-24-32(39)26-17-21(34(40)41)6-11-29(26)44-33(24)23(28)10-13-31(37)38/h4-9,11-12,16-18,36H,2-3,10,13-15H2,1H3,(H,37,38)(H,40,41)
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 0.470n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
LTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]-LTB4 in human neutrophil

Bioorg Med Chem Lett 4: 2077-2082 (1994)


Article DOI: 10.1016/S0960-894X(01)80105-0
BindingDB Entry DOI: 10.7270/Q27D2V2X
More data for this
Ligand-Target Pair
Leukotriene B4 receptor 1


(Homo sapiens (Human))		BDBM50029464
PNG
(5-(2-Carboxy-ethyl)-6-[3-(5-ethyl-4'-fluoro-2-hydr...)
Show SMILES CCc1cc(c(O)cc1OCCCOc1ccc2c(oc3ccc(cc3c2=O)C(O)=O)c1CCC(O)=O)-c1ccc(F)cc1
Show InChI InChI=1S/C34H29FO9/c1-2-19-16-25(20-4-7-22(35)8-5-20)27(36)18-30(19)43-15-3-14-42-28-12-9-24-32(39)26-17-21(34(40)41)6-11-29(26)44-33(24)23(28)10-13-31(37)38/h4-9,11-12,16-18,36H,2-3,10,13-15H2,1H3,(H,37,38)(H,40,41)
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 0.470n/an/an/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Tested for inhibition of specific binding of [3H]-LTB4 to human neutrophil expressing LTB4 receptor

J Med Chem 36: 3982-4 (1994)


BindingDB Entry DOI: 10.7270/Q2H1313H
More data for this
Ligand-Target Pair
Leukotriene B4 receptor 1


(Homo sapiens (Human))		BDBM50029477
PNG
(5-(2-Carboxy-ethyl)-6-[3-(5-ethyl-2-hydroxy-biphen...)
Show SMILES CCc1cc(c(O)cc1OCCCOc1ccc2c(oc3ccc(cc3c2=O)C(O)=O)c1CCC(O)=O)-c1ccccc1
Show InChI InChI=1S/C34H30O9/c1-2-20-17-25(21-7-4-3-5-8-21)27(35)19-30(20)42-16-6-15-41-28-13-10-24-32(38)26-18-22(34(39)40)9-12-29(26)43-33(24)23(28)11-14-31(36)37/h3-5,7-10,12-13,17-19,35H,2,6,11,14-16H2,1H3,(H,36,37)(H,39,40)
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 0.570n/an/an/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Tested for inhibition of specific binding of [3H]-LTB4 to human neutrophil expressing LTB4 receptor

J Med Chem 36: 3982-4 (1994)


BindingDB Entry DOI: 10.7270/Q2H1313H
More data for this
Ligand-Target Pair
Leukotriene B4 receptor 1


(Homo sapiens (Human))		BDBM50283054
PNG
(4-{2-(2-Carboxy-ethyl)-3-[3-(5-ethyl-4'-fluoro-2-h...)
Show SMILES CCc1cc(c(O)cc1OCCCOc1cccc(Oc2ccc(cc2)C(O)=O)c1CCC(O)=O)-c1ccc(F)cc1
Show InChI InChI=1S/C33H31FO8/c1-2-21-19-27(22-7-11-24(34)12-8-22)28(35)20-31(21)41-18-4-17-40-29-5-3-6-30(26(29)15-16-32(36)37)42-25-13-9-23(10-14-25)33(38)39/h3,5-14,19-20,35H,2,4,15-18H2,1H3,(H,36,37)(H,38,39)
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 1.10n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
LTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]-LTB4 in human neutrophil

Bioorg Med Chem Lett 4: 2077-2082 (1994)


Article DOI: 10.1016/S0960-894X(01)80105-0
BindingDB Entry DOI: 10.7270/Q27D2V2X
More data for this
Ligand-Target Pair
Leukotriene B4 receptor 1


(Homo sapiens (Human))		BDBM50029482
PNG
(6-[3-(4-Acetyl-2-ethyl-5-hydroxy-phenoxy)-propoxy]...)
Show SMILES CCc1cc(C(C)=O)c(O)cc1OCCCOc1ccc2c(oc3ccc(cc3c2=O)C(O)=O)c1CCC(O)=O
Show InChI InChI=1S/C30H28O10/c1-3-17-13-21(16(2)31)23(32)15-26(17)39-12-4-11-38-24-9-6-20-28(35)22-14-18(30(36)37)5-8-25(22)40-29(20)19(24)7-10-27(33)34/h5-6,8-9,13-15,32H,3-4,7,10-12H2,1-2H3,(H,33,34)(H,36,37)
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 1.20n/an/an/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Tested for inhibition of specific binding of [3H]-LTB4 to guinea pig lung membranes expressing LTB4 receptor

J Med Chem 36: 3982-4 (1994)


BindingDB Entry DOI: 10.7270/Q2H1313H
More data for this
Ligand-Target Pair
Leukotriene B4 receptor 1


(Homo sapiens (Human))		BDBM50029482
PNG
(6-[3-(4-Acetyl-2-ethyl-5-hydroxy-phenoxy)-propoxy]...)
Show SMILES CCc1cc(C(C)=O)c(O)cc1OCCCOc1ccc2c(oc3ccc(cc3c2=O)C(O)=O)c1CCC(O)=O
Show InChI InChI=1S/C30H28O10/c1-3-17-13-21(16(2)31)23(32)15-26(17)39-12-4-11-38-24-9-6-20-28(35)22-14-18(30(36)37)5-8-25(22)40-29(20)19(24)7-10-27(33)34/h5-6,8-9,13-15,32H,3-4,7,10-12H2,1-2H3,(H,33,34)(H,36,37)
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 1.20n/an/an/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Tested for inhibition of specific binding of [3H]-LTB4 to guinea pig lung membranes expressing LTB4 receptor

J Med Chem 36: 3982-4 (1994)


BindingDB Entry DOI: 10.7270/Q2H1313H
More data for this
Ligand-Target Pair
Leukotriene B4 receptor 1


(Homo sapiens (Human))		BDBM50280884
PNG
(3-{3-[3-(4-acetyl-2-ethyl-5-olatophenoxy)propoxy]-...)
Show SMILES CCc1cc(C(C)=O)c([O-])cc1OCCCOc1ccc2c(oc3ccc(cc3c2=O)C([O-])=O)c1CCC([O-])=O
Show InChI InChI=1S/C30H28O10/c1-3-17-13-21(16(2)31)23(32)15-26(17)39-12-4-11-38-24-9-6-20-28(35)22-14-18(30(36)37)5-8-25(22)40-29(20)19(24)7-10-27(33)34/h5-6,8-9,13-15,32H,3-4,7,10-12H2,1-2H3,(H,33,34)(H,36,37)/p-3
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 1.20n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranes

Bioorg Med Chem Lett 3: 1981-1984 (1993)


Article DOI: 10.1016/S0960-894X(01)80999-9
BindingDB Entry DOI: 10.7270/Q2VH5P9R
More data for this
Ligand-Target Pair
Leukotriene B4 receptor 1


(Homo sapiens (Human))		BDBM50013889
PNG
((5S,6Z,8E,10E,12R,14Z)-5,12-dihydroxyicosa-6,8,10,...)
Show SMILES CCCCC\C=C/C[C@@H](O)\C=C\C=C\C=C/[C@@H](O)CCCC(O)=O |r|
Show InChI InChI=1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/b8-7+,9-6-,14-10+,15-11-/t18-,19-/m1/s1
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Article
 1.90n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
LTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]-LTB4 in guinea pig lung membranes

Bioorg Med Chem Lett 4: 2077-2082 (1994)


Article DOI: 10.1016/S0960-894X(01)80105-0
BindingDB Entry DOI: 10.7270/Q27D2V2X
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Leukotriene B4 receptor 1


(Homo sapiens (Human))		BDBM50013889
PNG
((5S,6Z,8E,10E,12R,14Z)-5,12-dihydroxyicosa-6,8,10,...)
Show SMILES CCCCC\C=C/C[C@@H](O)\C=C\C=C\C=C/[C@@H](O)CCCC(O)=O |r|
Show InChI InChI=1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/b8-7+,9-6-,14-10+,15-11-/t18-,19-/m1/s1
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 1.90n/an/an/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Tested for inhibition of specific binding of [3H]-LTB4 to human neutrophil expressing LTB4 receptor

J Med Chem 36: 3982-4 (1994)


BindingDB Entry DOI: 10.7270/Q2H1313H
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
D(1A) dopamine receptor


(RAT)		BDBM60917
PNG
(9-chloranyl-5-(4-hydroxyphenyl)-2,3,4,5-tetrahydro...)
Show SMILES Oc1ccc(cc1)C1CNCCc2c(Cl)c(O)c(O)cc12
Show InChI InChI=1S/C16H16ClNO3/c17-15-11-5-6-18-8-13(9-1-3-10(19)4-2-9)12(11)7-14(20)16(15)21/h1-4,7,13,18-21H,5-6,8H2
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 3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes

J Med Chem 29: 1904-12 (1986)


BindingDB Entry DOI: 10.7270/Q2TQ623R
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Leukotriene B4 receptor 1


(Homo sapiens (Human))		BDBM50045092
PNG
(5-(2-Carboxy-ethyl)-6-[(E)-6-(4-methoxy-phenyl)-he...)
Show SMILES COc1ccc(\C=C\CCCCOc2ccc3c(oc4ccc(cc4c3=O)C(O)=O)c2CCC(O)=O)cc1
Show InChI InChI=1S/C30H28O8/c1-36-21-10-7-19(8-11-21)6-4-2-3-5-17-37-25-15-12-23-28(33)24-18-20(30(34)35)9-14-26(24)38-29(23)22(25)13-16-27(31)32/h4,6-12,14-15,18H,2-3,5,13,16-17H2,1H3,(H,31,32)(H,34,35)/b6-4+
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 5.90n/an/an/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition constant against binding of [3H]-LTB4 to human neutrophils

J Med Chem 36: 1726-34 (1993)


BindingDB Entry DOI: 10.7270/Q2JQ1023
More data for this
Ligand-Target Pair
Leukotriene B4 receptor 1


(Homo sapiens (Human))		BDBM50029462
PNG
(2-{3-[3-(5-Ethyl-4'-fluoro-2-hydroxy-biphenyl-4-yl...)
Show SMILES CCCc1c(OCCCOc2cc(O)c(cc2CC)-c2ccc(F)cc2)cccc1S(=O)c1ccccc1C(O)=O
Show InChI InChI=1S/C33H33FO6S/c1-3-9-25-29(11-7-13-31(25)41(38)32-12-6-5-10-26(32)33(36)37)39-18-8-19-40-30-21-28(35)27(20-22(30)4-2)23-14-16-24(34)17-15-23/h5-7,10-17,20-21,35H,3-4,8-9,18-19H2,1-2H3,(H,36,37)
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 5.90n/an/an/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards LTB4 receptor guinea pig spleen cells using [3H]-LTB4 as radioligand

J Med Chem 38: 4411-32 (1995)


BindingDB Entry DOI: 10.7270/Q20V8BSQ
More data for this
Ligand-Target Pair
Leukotriene B4 receptor 1


(Homo sapiens (Human))		BDBM50280886
PNG
(3-[2-[3-(4-acetyl-2-ethyl-5-olatophenoxy)propoxy]-...)
Show SMILES CCc1cc(C(C)=O)c([O-])cc1OCCCOc1ccc(cc1CCC([O-])=O)C(=O)c1cccc(c1)C([O-])=O
Show InChI InChI=1S/C30H30O9/c1-3-19-16-24(18(2)31)25(32)17-27(19)39-13-5-12-38-26-10-8-22(14-20(26)9-11-28(33)34)29(35)21-6-4-7-23(15-21)30(36)37/h4,6-8,10,14-17,32H,3,5,9,11-13H2,1-2H3,(H,33,34)(H,36,37)/p-3
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 6.80n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranes

Bioorg Med Chem Lett 3: 1981-1984 (1993)


Article DOI: 10.1016/S0960-894X(01)80999-9
BindingDB Entry DOI: 10.7270/Q2VH5P9R
More data for this
Ligand-Target Pair
Leukotriene B4 receptor 1


(Homo sapiens (Human))		BDBM50001611
PNG
((E)-3-{3-(2-Carboxy-ethyl)-4-[6-(4-methoxy-phenyl)...)
Show SMILES COc1ccc(\C=C\CCCCOc2ccc(cc2CCC(O)=O)C(=O)c2cccc(c2)C(O)=O)cc1
Show InChI InChI=1S/C30H30O7/c1-36-26-14-10-21(11-15-26)7-4-2-3-5-18-37-27-16-12-24(19-22(27)13-17-28(31)32)29(33)23-8-6-9-25(20-23)30(34)35/h4,6-12,14-16,19-20H,2-3,5,13,17-18H2,1H3,(H,31,32)(H,34,35)/b7-4+
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 7.80n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranes

Bioorg Med Chem Lett 3: 1981-1984 (1993)


Article DOI: 10.1016/S0960-894X(01)80999-9
BindingDB Entry DOI: 10.7270/Q2VH5P9R
More data for this
Ligand-Target Pair
Leukotriene B4 receptor 1


(Homo sapiens (Human))		BDBM50029448
PNG
(3-{3-[3-(5-Ethyl-2-hydroxy-biphenyl-4-yloxy)-propo...)
Show SMILES CCc1cc(c(O)cc1OCCCOc1ccc2c(oc3ccccc3c2=O)c1CCC(O)=O)-c1ccccc1
Show InChI InChI=1S/C33H30O7/c1-2-21-19-26(22-9-4-3-5-10-22)27(34)20-30(21)39-18-8-17-38-28-15-13-25-32(37)23-11-6-7-12-29(23)40-33(25)24(28)14-16-31(35)36/h3-7,9-13,15,19-20,34H,2,8,14,16-18H2,1H3,(H,35,36)
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 12n/an/an/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Tested for inhibition of specific binding of [3H]-LTB4 to guinea pig lung membranes expressing LTB4 receptor

J Med Chem 36: 3982-4 (1994)


BindingDB Entry DOI: 10.7270/Q2H1313H
More data for this
Ligand-Target Pair
Leukotriene B4 receptor 1


(Homo sapiens (Human))		BDBM50283056
PNG
(4-{4-(2-Carboxy-ethyl)-3-[3-(5-ethyl-4'-fluoro-2-h...)
Show SMILES CCc1cc(c(O)cc1OCCCOc1cc(Oc2ccc(cc2)C(O)=O)ccc1CCC(O)=O)-c1ccc(F)cc1
Show InChI InChI=1S/C33H31FO8/c1-2-21-18-28(22-4-10-25(34)11-5-22)29(35)20-31(21)41-17-3-16-40-30-19-27(14-6-23(30)9-15-32(36)37)42-26-12-7-24(8-13-26)33(38)39/h4-8,10-14,18-20,35H,2-3,9,15-17H2,1H3,(H,36,37)(H,38,39)
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 14n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
LTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]-LTB4 in guinea pig lung membranes

Bioorg Med Chem Lett 4: 2077-2082 (1994)


Article DOI: 10.1016/S0960-894X(01)80105-0
BindingDB Entry DOI: 10.7270/Q27D2V2X
More data for this
Ligand-Target Pair
Leukotriene B4 receptor 1


(Homo sapiens (Human))		BDBM50283056
PNG
(4-{4-(2-Carboxy-ethyl)-3-[3-(5-ethyl-4'-fluoro-2-h...)
Show SMILES CCc1cc(c(O)cc1OCCCOc1cc(Oc2ccc(cc2)C(O)=O)ccc1CCC(O)=O)-c1ccc(F)cc1
Show InChI InChI=1S/C33H31FO8/c1-2-21-18-28(22-4-10-25(34)11-5-22)29(35)20-31(21)41-17-3-16-40-30-19-27(14-6-23(30)9-15-32(36)37)42-26-12-7-24(8-13-26)33(38)39/h4-8,10-14,18-20,35H,2-3,9,15-17H2,1H3,(H,36,37)(H,38,39)
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 14n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
LTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]-LTB4 in human neutrophil

Bioorg Med Chem Lett 4: 2077-2082 (1994)


Article DOI: 10.1016/S0960-894X(01)80105-0
BindingDB Entry DOI: 10.7270/Q27D2V2X
More data for this
Ligand-Target Pair
Leukotriene B4 receptor 1


(Homo sapiens (Human))		BDBM50029448
PNG
(3-{3-[3-(5-Ethyl-2-hydroxy-biphenyl-4-yloxy)-propo...)
Show SMILES CCc1cc(c(O)cc1OCCCOc1ccc2c(oc3ccccc3c2=O)c1CCC(O)=O)-c1ccccc1
Show InChI InChI=1S/C33H30O7/c1-2-21-19-26(22-9-4-3-5-10-22)27(34)20-30(21)39-18-8-17-38-28-15-13-25-32(37)23-11-6-7-12-29(23)40-33(25)24(28)14-16-31(35)36/h3-7,9-13,15,19-20,34H,2,8,14,16-18H2,1H3,(H,35,36)
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 22n/an/an/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Tested for inhibition of specific binding of [3H]-LTB4 to guinea pig lung membranes expressing LTB4 receptor

J Med Chem 36: 3982-4 (1994)


BindingDB Entry DOI: 10.7270/Q2H1313H
More data for this
Ligand-Target Pair
Leukotriene B4 receptor 1


(Homo sapiens (Human))		BDBM50029452
PNG
(2-{3-[3-(5-Ethyl-4'-fluoro-2-hydroxy-biphenyl-4-yl...)
Show SMILES CCCc1c(Cc2ccccc2C(O)=O)cccc1OCCCOc1cc(O)c(cc1CC)-c1ccc(F)cc1
Show InChI InChI=1S/C34H35FO5/c1-3-9-28-25(20-26-10-5-6-12-29(26)34(37)38)11-7-13-32(28)39-18-8-19-40-33-22-31(36)30(21-23(33)4-2)24-14-16-27(35)17-15-24/h5-7,10-17,21-22,36H,3-4,8-9,18-20H2,1-2H3,(H,37,38)
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 25n/an/an/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards LTB4 receptor guinea pig spleen cells using [3H]-LTB4 as radioligand

J Med Chem 38: 4411-32 (1995)


BindingDB Entry DOI: 10.7270/Q20V8BSQ
More data for this
Ligand-Target Pair
Leukotriene B4 receptor 1


(Homo sapiens (Human))		BDBM50029468
PNG
(2-{3-[3-(5-Ethyl-4'-fluoro-2-hydroxy-biphenyl-4-yl...)
Show SMILES CCCc1c(OCCCOc2cc(O)c(cc2CC)-c2ccc(F)cc2)cccc1C(=O)c1ccccc1C(O)=O
Show InChI InChI=1S/C34H33FO6/c1-3-9-25-26(33(37)27-10-5-6-11-28(27)34(38)39)12-7-13-31(25)40-18-8-19-41-32-21-30(36)29(20-22(32)4-2)23-14-16-24(35)17-15-23/h5-7,10-17,20-21,36H,3-4,8-9,18-19H2,1-2H3,(H,38,39)
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 33n/an/an/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards LTB4 receptor guinea pig spleen cells using [3H]-LTB4 as radioligand

J Med Chem 38: 4411-32 (1995)


BindingDB Entry DOI: 10.7270/Q20V8BSQ
More data for this
Ligand-Target Pair
Leukotriene B4 receptor 1


(Homo sapiens (Human))		BDBM50029460
PNG
(3-{3-[3-(5-Ethyl-4'-fluoro-2-hydroxy-biphenyl-4-yl...)
Show SMILES CCc1cc(c(O)cc1OCCCOc1ccc2c(oc3ccccc3c2=O)c1CCC(O)=O)-c1ccc(F)cc1
Show InChI InChI=1S/C33H29FO7/c1-2-20-18-26(21-8-10-22(34)11-9-21)27(35)19-30(20)40-17-5-16-39-28-14-12-25-32(38)23-6-3-4-7-29(23)41-33(25)24(28)13-15-31(36)37/h3-4,6-12,14,18-19,35H,2,5,13,15-17H2,1H3,(H,36,37)
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 36n/an/an/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Tested for inhibition of specific binding of [3H]-LTB4 to human neutrophil expressing LTB4 receptor

J Med Chem 36: 3982-4 (1994)


BindingDB Entry DOI: 10.7270/Q2H1313H
More data for this
Ligand-Target Pair
Leukotriene B4 receptor 1


(Homo sapiens (Human))		BDBM50029460
PNG
(3-{3-[3-(5-Ethyl-4'-fluoro-2-hydroxy-biphenyl-4-yl...)
Show SMILES CCc1cc(c(O)cc1OCCCOc1ccc2c(oc3ccccc3c2=O)c1CCC(O)=O)-c1ccc(F)cc1
Show InChI InChI=1S/C33H29FO7/c1-2-20-18-26(21-8-10-22(34)11-9-21)27(35)19-30(20)40-17-5-16-39-28-14-12-25-32(38)23-6-3-4-7-29(23)41-33(25)24(28)13-15-31(36)37/h3-4,6-12,14,18-19,35H,2,5,13,15-17H2,1H3,(H,36,37)
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 36n/an/an/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Tested for inhibition of specific binding of [3H]-LTB4 to guinea pig lung membranes expressing LTB4 receptor

J Med Chem 36: 3982-4 (1994)


BindingDB Entry DOI: 10.7270/Q2H1313H
More data for this
Ligand-Target Pair
Leukotriene B4 receptor 1


(Homo sapiens (Human))		BDBM50029467
PNG
(2-{3-[3-(5-Ethyl-4'-fluoro-2-hydroxy-biphenyl-4-yl...)
Show SMILES CCCc1c(OCCCOc2cc(O)c(cc2CC)-c2ccc(F)cc2)cccc1S(=O)(=O)c1ccccc1C(O)=O
Show InChI InChI=1S/C33H33FO7S/c1-3-9-25-29(11-7-13-31(25)42(38,39)32-12-6-5-10-26(32)33(36)37)40-18-8-19-41-30-21-28(35)27(20-22(30)4-2)23-14-16-24(34)17-15-23/h5-7,10-17,20-21,35H,3-4,8-9,18-19H2,1-2H3,(H,36,37)
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 36n/an/an/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards LTB4 receptor guinea pig spleen cells using [3H]-LTB4 as radioligand

J Med Chem 38: 4411-32 (1995)


BindingDB Entry DOI: 10.7270/Q20V8BSQ
More data for this
Ligand-Target Pair
Leukotriene B4 receptor 1


(Homo sapiens (Human))		BDBM50029484
PNG
(2-{3-[3-(5-Ethyl-4'-fluoro-2-hydroxy-biphenyl-4-yl...)
Show SMILES CCCc1c(OCCCOc2cc(O)c(cc2CC)-c2ccc(F)cc2)cccc1Sc1ccccc1C(O)=O
Show InChI InChI=1S/C33H33FO5S/c1-3-9-25-29(11-7-13-31(25)40-32-12-6-5-10-26(32)33(36)37)38-18-8-19-39-30-21-28(35)27(20-22(30)4-2)23-14-16-24(34)17-15-23/h5-7,10-17,20-21,35H,3-4,8-9,18-19H2,1-2H3,(H,36,37)
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 42n/an/an/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards LTB4 receptor guinea pig spleen cells using [3H]-LTB4 as radioligand

J Med Chem 38: 4411-32 (1995)


BindingDB Entry DOI: 10.7270/Q20V8BSQ
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(RAT)		BDBM50025202
PNG
(9-Aminomethyl-9H-fluorene-2,5,6-triol | CHEMBL5767...)
Show SMILES NCC1c2cc(O)ccc2-c2c1ccc(O)c2O
Show InChI InChI=1S/C14H13NO3/c15-6-11-9-3-4-12(17)14(18)13(9)8-2-1-7(16)5-10(8)11/h1-5,11,16-18H,6,15H2
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 43n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes

J Med Chem 29: 1904-12 (1986)


BindingDB Entry DOI: 10.7270/Q2TQ623R
More data for this
Ligand-Target Pair
Leukotriene B4 receptor 1


(Homo sapiens (Human))		BDBM50045092
PNG
(5-(2-Carboxy-ethyl)-6-[(E)-6-(4-methoxy-phenyl)-he...)
Show SMILES COc1ccc(\C=C\CCCCOc2ccc3c(oc4ccc(cc4c3=O)C(O)=O)c2CCC(O)=O)cc1
Show InChI InChI=1S/C30H28O8/c1-36-21-10-7-19(8-11-21)6-4-2-3-5-17-37-25-15-12-23-28(33)24-18-20(30(34)35)9-14-26(24)38-29(23)22(25)13-16-27(31)32/h4,6-12,14-15,18H,2-3,5,13,16-17H2,1H3,(H,31,32)(H,34,35)/b6-4+
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 45n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophils

Bioorg Med Chem Lett 3: 1981-1984 (1993)


Article DOI: 10.1016/S0960-894X(01)80999-9
BindingDB Entry DOI: 10.7270/Q2VH5P9R
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(RAT)		BDBM50001955
PNG
((-)6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]qu...)
Show SMILES CN1CCc2cccc-3c2[C@H]1Cc1ccc(O)c(O)c-31 |r|
Show InChI InChI=1S/C17H17NO2/c1-18-8-7-10-3-2-4-12-15(10)13(18)9-11-5-6-14(19)17(20)16(11)12/h2-6,13,19-20H,7-9H2,1H3/t13-/m1/s1
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 53n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes

J Med Chem 29: 1904-12 (1986)


BindingDB Entry DOI: 10.7270/Q2TQ623R
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Dopamine beta-hydroxylase


(Bos taurus)		BDBM50014968
PNG
(1-(4-Hydroxy-benzyl)-1,3-dihydro-imidazole-2-thion...)
Show SMILES Oc1ccc(Cn2cc[nH]c2=S)cc1
Show InChI InChI=1S/C10H10N2OS/c13-9-3-1-8(2-4-9)7-12-6-5-11-10(12)14/h1-6,13H,7H2,(H,11,14)
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 55n/an/an/an/an/an/a4.5n/a



TBA

Curated by ChEMBL


Assay Description
Compound was evaluated for the inhibition of Dopamine beta hydroxylase at pH 4.5

J Med Chem 29: 2465-72 (1987)


BindingDB Entry DOI: 10.7270/Q2BR8R5P
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(RAT)		BDBM50025206
PNG
((6,7-Dihydroxy-1,2,3,4-tetrahydro-naphthalen-2-yl)...)
Show SMILES C[NH+](C)C1CCc2cc(O)c(O)cc2C1
Show InChI InChI=1S/C12H17NO2/c1-13(2)10-4-3-8-6-11(14)12(15)7-9(8)5-10/h6-7,10,14-15H,3-5H2,1-2H3/p+1
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 57n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes

J Med Chem 29: 1904-12 (1986)


BindingDB Entry DOI: 10.7270/Q2TQ623R
More data for this
Ligand-Target Pair
Leukotriene B4 receptor 1


(Homo sapiens (Human))		BDBM81519
PNG
(CAS_117690-79-6 | CGS 23356 | CHEMBL15766 | LY 255...)
Show SMILES CCc1cc(C(C)=O)c(O)cc1OCCCCCC(C)(C)c1nnn[nH]1
Show InChI InChI=1S/C19H28N4O3/c1-5-14-11-15(13(2)24)16(25)12-17(14)26-10-8-6-7-9-19(3,4)18-20-22-23-21-18/h11-12,25H,5-10H2,1-4H3,(H,20,21,22,23)
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 77n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranes

Bioorg Med Chem Lett 3: 1981-1984 (1993)


Article DOI: 10.1016/S0960-894X(01)80999-9
BindingDB Entry DOI: 10.7270/Q2VH5P9R
More data for this
Ligand-Target Pair
Dopamine beta-hydroxylase


(Bos taurus)		BDBM50000439
PNG
(5-Butyl-pyridine-2-carboxylic acid | 5-Butyl-pyrid...)
Show SMILES CCCCc1ccc(nc1)C(O)=O
Show InChI InChI=1S/C10H13NO2/c1-2-3-4-8-5-6-9(10(12)13)11-7-8/h5-7H,2-4H2,1H3,(H,12,13)
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 149n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was evaluated for the inhibition of Dopamine beta hydroxylase at pH 4.5

J Med Chem 29: 2465-72 (1987)


BindingDB Entry DOI: 10.7270/Q2BR8R5P
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(RAT)		BDBM55121
PNG
(3-HYDROXYTYRAMINE HYDROCHLORIDE | 4-(2-aminoethyl)...)
Show SMILES NCCc1ccc(O)c(O)c1
Show InChI InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2
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 150n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes

J Med Chem 29: 1904-12 (1986)


BindingDB Entry DOI: 10.7270/Q2TQ623R
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
D(2) dopamine receptor


(BOVINE)		BDBM50001955
PNG
((-)6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]qu...)
Show SMILES CN1CCc2cccc-3c2[C@H]1Cc1ccc(O)c(O)c-31 |r|
Show InChI InChI=1S/C17H17NO2/c1-18-8-7-10-3-2-4-12-15(10)13(18)9-11-5-6-14(19)17(20)16(11)12/h2-6,13,19-20H,7-9H2,1H3/t13-/m1/s1
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 200n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was tested for inhibition of [3H]spiroperidol binding against Dopamine receptor D2

J Med Chem 29: 1904-12 (1986)


BindingDB Entry DOI: 10.7270/Q2TQ623R
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(BOVINE)		BDBM50025206
PNG
((6,7-Dihydroxy-1,2,3,4-tetrahydro-naphthalen-2-yl)...)
Show SMILES C[NH+](C)C1CCc2cc(O)c(O)cc2C1
Show InChI InChI=1S/C12H17NO2/c1-13(2)10-4-3-8-6-11(14)12(15)7-9(8)5-10/h6-7,10,14-15H,3-5H2,1-2H3/p+1
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 255n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was tested for inhibition of [3H]spiroperidol binding against Dopamine receptor D2

J Med Chem 29: 1904-12 (1986)


BindingDB Entry DOI: 10.7270/Q2TQ623R
More data for this
Ligand-Target Pair
Dopamine beta-hydroxylase


(Bos taurus)		BDBM50014968
PNG
(1-(4-Hydroxy-benzyl)-1,3-dihydro-imidazole-2-thion...)
Show SMILES Oc1ccc(Cn2cc[nH]c2=S)cc1
Show InChI InChI=1S/C10H10N2OS/c13-9-3-1-8(2-4-9)7-12-6-5-11-10(12)14/h1-6,13H,7H2,(H,11,14)
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 344n/an/an/an/an/an/a6.6n/a



TBA

Curated by ChEMBL


Assay Description
Compound was evaluated for the inhibition of Dopamine beta hydroxylase at pH 6.6

J Med Chem 29: 2465-72 (1987)


BindingDB Entry DOI: 10.7270/Q2BR8R5P
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(RAT)		BDBM50025201
PNG
(9-Aminomethyl-9H-fluorene-3,4-diol | CHEMBL55693)
Show SMILES NCC1c2ccccc2-c2c1ccc(O)c2O
Show InChI InChI=1S/C14H13NO2/c15-7-11-8-3-1-2-4-9(8)13-10(11)5-6-12(16)14(13)17/h1-6,11,16-17H,7,15H2
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 380n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes

J Med Chem 29: 1904-12 (1986)


BindingDB Entry DOI: 10.7270/Q2TQ623R
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(RAT)		BDBM50025208
PNG
(6-Chloro-9-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]az...)
Show SMILES Oc1c(O)c(c2CCNCCc2c1Cl)-c1ccccc1
Show InChI InChI=1S/C16H16ClNO2/c17-14-12-7-9-18-8-6-11(12)13(15(19)16(14)20)10-4-2-1-3-5-10/h1-5,18-20H,6-9H2
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 700n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes

J Med Chem 29: 1904-12 (1986)


BindingDB Entry DOI: 10.7270/Q2TQ623R
More data for this
Ligand-Target Pair
Leukotriene B4 receptor 1


(Homo sapiens (Human))		BDBM50280885
PNG
(CHEMBL58534 | disodium 6-[3-(4-acetyl-2-ethyl-5-ol...)
Show SMILES CCc1cc(C(C)=O)c([O-])cc1OCCCOc1ccc2c(c1)oc1ccc(cc1c2=O)C([O-])=O
Show InChI InChI=1S/C27H24O8/c1-3-16-11-20(15(2)28)22(29)14-24(16)34-10-4-9-33-18-6-7-19-25(13-18)35-23-8-5-17(27(31)32)12-21(23)26(19)30/h5-8,11-14,29H,3-4,9-10H2,1-2H3,(H,31,32)/p-2
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 751n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranes

Bioorg Med Chem Lett 3: 1981-1984 (1993)


Article DOI: 10.1016/S0960-894X(01)80999-9
BindingDB Entry DOI: 10.7270/Q2VH5P9R
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(BOVINE)		BDBM60917
PNG
(9-chloranyl-5-(4-hydroxyphenyl)-2,3,4,5-tetrahydro...)
Show SMILES Oc1ccc(cc1)C1CNCCc2c(Cl)c(O)c(O)cc12
Show InChI InChI=1S/C16H16ClNO3/c17-15-11-5-6-18-8-13(9-1-3-10(19)4-2-9)12(11)7-14(20)16(15)21/h1-4,7,13,18-21H,5-6,8H2
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 790n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was tested for inhibition of [3H]spiroperidol binding against Dopamine receptor D2

J Med Chem 29: 1904-12 (1986)


BindingDB Entry DOI: 10.7270/Q2TQ623R
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(RAT)		BDBM50004821
PNG
(2,3,4,5-Tetrahydro-1H-benzo[d]azepine-7,8-diol | C...)
Show SMILES Oc1cc2CCNCCc2cc1O
Show InChI InChI=1S/C10H13NO2/c12-9-5-7-1-3-11-4-2-8(7)6-10(9)13/h5-6,11-13H,1-4H2
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 970n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was tested for binding affinity against dDopamine receptor D1 using [3H]fenoldopam as a radioligand

J Med Chem 29: 1904-12 (1986)


BindingDB Entry DOI: 10.7270/Q2TQ623R
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(RAT)		BDBM50025204
PNG
(6-(2-Amino-ethyl)-biphenyl-2,3-diol | CHEMBL299511)
Show SMILES NCCc1ccc(O)c(O)c1-c1ccccc1
Show InChI InChI=1S/C14H15NO2/c15-9-8-11-6-7-12(16)14(17)13(11)10-4-2-1-3-5-10/h1-7,16-17H,8-9,15H2
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 1.50E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes

J Med Chem 29: 1904-12 (1986)


BindingDB Entry DOI: 10.7270/Q2TQ623R
More data for this
Ligand-Target Pair
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