Found 1042 hits with Last Name = 'sheng' and Initial = 'r' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
E3 ubiquitin-protein ligase XIAP
(Homo sapiens (Human)) | BDBM50432760
(CHEMBL2348620)Show SMILES CN[C@@H](C)C(=O)N[C@H]1CN(CC[C@H]2CC[C@H](N2C1=O)C(=O)NC(c1ccccc1)c1ccccc1)C(=O)Nc1ccc(Cc2ccc(NC(=O)N3CC[C@H]4CC[C@H](N4C(=O)[C@H](C3)NC(=O)[C@H](C)NC)C(=O)NC(c3ccccc3)c3ccccc3)cc2)cc1 |r| Show InChI InChI=1S/C69H80N12O8/c1-44(70-3)62(82)74-56-42-78(39-37-54-33-35-58(80(54)66(56)86)64(84)76-60(48-17-9-5-10-18-48)49-19-11-6-12-20-49)68(88)72-52-29-25-46(26-30-52)41-47-27-31-53(32-28-47)73-69(89)79-40-38-55-34-36-59(81(55)67(87)57(43-79)75-63(83)45(2)71-4)65(85)77-61(50-21-13-7-14-22-50)51-23-15-8-16-24-51/h5-32,44-45,54-61,70-71H,33-43H2,1-4H3,(H,72,88)(H,73,89)(H,74,82)(H,75,83)(H,76,84)(H,77,85)/t44-,45-,54+,55+,56-,57-,58-,59-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 0.700 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Michigan
Curated by ChEMBL
| Assay Description
Binding affinity to XIAP linker BIR2-BIR3 domain (unknown origin) after 3 hrs by competitive fluorescence polarization assay in presence of Smac-1F |
J Med Chem 56: 3969-79 (2013)
Article DOI: 10.1021/jm400216d
BindingDB Entry DOI: 10.7270/Q2M61MNM |
More data for this
Ligand-Target Pair | |
E3 ubiquitin-protein ligase XIAP
(Homo sapiens (Human)) | BDBM50432754
(CHEMBL2348614)Show SMILES CN[C@@H](C)C(=O)N[C@H]1CN(CC[C@H]2CC[C@H](N2C1=O)C(=O)NC(c1ccccc1)c1ccccc1)C(=O)Cc1ccc(CC(=O)N2CC[C@H]3CC[C@H](N3C(=O)[C@H](C2)NC(=O)[C@H](C)NC)C(=O)NC(c2ccccc2)c2ccccc2)cc1 |r| Show InChI InChI=1S/C64H76N10O8/c1-41(65-3)59(77)67-51-39-71(35-33-49-29-31-53(73(49)63(51)81)61(79)69-57(45-17-9-5-10-18-45)46-19-11-6-12-20-46)55(75)37-43-25-27-44(28-26-43)38-56(76)72-36-34-50-30-32-54(74(50)64(82)52(40-72)68-60(78)42(2)66-4)62(80)70-58(47-21-13-7-14-22-47)48-23-15-8-16-24-48/h5-28,41-42,49-54,57-58,65-66H,29-40H2,1-4H3,(H,67,77)(H,68,78)(H,69,79)(H,70,80)/t41-,42-,49+,50+,51-,52-,53-,54-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 1.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Michigan
Curated by ChEMBL
| Assay Description
Binding affinity to XIAP linker BIR2-BIR3 domain (unknown origin) after 3 hrs by competitive fluorescence polarization assay in presence of Smac-1F |
J Med Chem 56: 3969-79 (2013)
Article DOI: 10.1021/jm400216d
BindingDB Entry DOI: 10.7270/Q2M61MNM |
More data for this
Ligand-Target Pair | |
E3 ubiquitin-protein ligase XIAP
(Homo sapiens (Human)) | BDBM50432753
(CHEMBL2348613)Show SMILES CN[C@@H](C)C(=O)N[C@H]1CN(CC[C@H]2CC[C@H](N2C1=O)C(=O)NC(c1ccccc1)c1ccccc1)C(=O)CCc1ccc(CCC(=O)N2CC[C@H]3CC[C@H](N3C(=O)[C@H](C2)NC(=O)[C@H](C)NC)C(=O)NC(c2ccccc2)c2ccccc2)cc1 |r| Show InChI InChI=1S/C66H80N10O8/c1-43(67-3)61(79)69-53-41-73(39-37-51-31-33-55(75(51)65(53)83)63(81)71-59(47-17-9-5-10-18-47)48-19-11-6-12-20-48)57(77)35-29-45-25-27-46(28-26-45)30-36-58(78)74-40-38-52-32-34-56(76(52)66(84)54(42-74)70-62(80)44(2)68-4)64(82)72-60(49-21-13-7-14-22-49)50-23-15-8-16-24-50/h5-28,43-44,51-56,59-60,67-68H,29-42H2,1-4H3,(H,69,79)(H,70,80)(H,71,81)(H,72,82)/t43-,44-,51+,52+,53-,54-,55-,56-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 1.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Michigan
Curated by ChEMBL
| Assay Description
Binding affinity to XIAP linker BIR2-BIR3 domain (unknown origin) after 3 hrs by competitive fluorescence polarization assay in presence of Smac-1F |
J Med Chem 56: 3969-79 (2013)
Article DOI: 10.1021/jm400216d
BindingDB Entry DOI: 10.7270/Q2M61MNM |
More data for this
Ligand-Target Pair | |
Baculoviral IAP repeat-containing protein 2
(Homo sapiens (Human)) | BDBM50432759
(CHEMBL2348619)Show SMILES CN[C@@H](C)C(=O)N[C@H]1CN(CC[C@H]2CC[C@H](N2C1=O)C(=O)NC(c1ccccc1)c1ccccc1)C(=O)Nc1ccc(Oc2ccc(NC(=O)N3CC[C@H]4CC[C@H](N4C(=O)[C@H](C3)NC(=O)[C@H](C)NC)C(=O)NC(c3ccccc3)c3ccccc3)cc2)cc1 |r| Show InChI InChI=1S/C68H78N12O9/c1-43(69-3)61(81)73-55-41-77(39-37-51-29-35-57(79(51)65(55)85)63(83)75-59(45-17-9-5-10-18-45)46-19-11-6-12-20-46)67(87)71-49-25-31-53(32-26-49)89-54-33-27-50(28-34-54)72-68(88)78-40-38-52-30-36-58(80(52)66(86)56(42-78)74-62(82)44(2)70-4)64(84)76-60(47-21-13-7-14-22-47)48-23-15-8-16-24-48/h5-28,31-34,43-44,51-52,55-60,69-70H,29-30,35-42H2,1-4H3,(H,71,87)(H,72,88)(H,73,81)(H,74,82)(H,75,83)(H,76,84)/t43-,44-,51+,52+,55-,56-,57-,58-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 1.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Michigan
Curated by ChEMBL
| Assay Description
Binding affinity to cIAP1 BIR3 domain (unknown origin) after 3 hrs by competitive fluorescence polarization assay in presence of Smac-2F |
J Med Chem 56: 3969-79 (2013)
Article DOI: 10.1021/jm400216d
BindingDB Entry DOI: 10.7270/Q2M61MNM |
More data for this
Ligand-Target Pair | |
E3 ubiquitin-protein ligase XIAP
(Homo sapiens (Human)) | BDBM50432762
(CHEMBL2348622)Show SMILES CN[C@@H](C)C(=O)N[C@H]1CN(CC[C@H]2CC[C@H](N2C1=O)C(=O)NC(c1ccccc1)c1ccccc1)C(=O)Nc1cccc(NC(=O)N2CC[C@H]3CC[C@H](N3C(=O)[C@H](C2)NC(=O)[C@H](C)NC)C(=O)NC(c2ccccc2)c2ccccc2)c1 |r| Show InChI InChI=1S/C62H74N12O8/c1-39(63-3)55(75)67-49-37-71(34-32-47-28-30-51(73(47)59(49)79)57(77)69-53(41-18-9-5-10-19-41)42-20-11-6-12-21-42)61(81)65-45-26-17-27-46(36-45)66-62(82)72-35-33-48-29-31-52(74(48)60(80)50(38-72)68-56(76)40(2)64-4)58(78)70-54(43-22-13-7-14-23-43)44-24-15-8-16-25-44/h5-27,36,39-40,47-54,63-64H,28-35,37-38H2,1-4H3,(H,65,81)(H,66,82)(H,67,75)(H,68,76)(H,69,77)(H,70,78)/t39-,40-,47+,48+,49-,50-,51-,52-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 1.70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Michigan
Curated by ChEMBL
| Assay Description
Binding affinity to XIAP linker BIR2-BIR3 domain (unknown origin) after 3 hrs by competitive fluorescence polarization assay in presence of Smac-1F |
J Med Chem 56: 3969-79 (2013)
Article DOI: 10.1021/jm400216d
BindingDB Entry DOI: 10.7270/Q2M61MNM |
More data for this
Ligand-Target Pair | |
E3 ubiquitin-protein ligase XIAP
(Homo sapiens (Human)) | BDBM50432758
(CHEMBL2348618)Show SMILES CN[C@@H](C)C(=O)N[C@H]1CN(CC[C@H]2CC[C@H](N2C1=O)C(=O)NC(c1ccccc1)c1ccccc1)C(=O)N[C@H]1CC[C@@H](CC1)NC(=O)N1CC[C@H]2CC[C@H](N2C(=O)[C@H](C1)NC(=O)[C@H](C)NC)C(=O)NC(c1ccccc1)c1ccccc1 |r,wU:38.41,50.59,53.72,57.65,62.69,wD:41.48,12.16,7.6,2.2,15.20,(49.77,-12.92,;51.31,-12.89,;52.07,-11.55,;53.61,-11.53,;51.28,-10.23,;52.03,-8.88,;49.74,-10.25,;48.95,-8.93,;49.87,-7.69,;49.64,-6.16,;48.41,-5.25,;46.89,-5.47,;45.97,-6.7,;44.45,-6.45,;43.73,-7.81,;44.81,-8.91,;46.19,-8.23,;47.42,-9.15,;47.04,-10.64,;44.55,-10.43,;45.74,-11.42,;43.11,-10.97,;41.77,-10.2,;41.77,-8.66,;43.1,-7.89,;43.1,-6.35,;41.77,-5.58,;40.44,-6.36,;40.44,-7.9,;40.45,-10.97,;39.12,-10.19,;37.79,-10.96,;37.78,-12.5,;39.14,-13.28,;40.46,-12.5,;50.97,-5.37,;50.95,-3.83,;52.31,-6.12,;53.85,-6.12,;54.61,-4.79,;56.15,-4.78,;56.92,-6.12,;56.15,-7.44,;54.62,-7.44,;58.46,-6.12,;59.79,-5.33,;59.79,-3.79,;61.13,-6.09,;62.36,-5.14,;63.88,-5.33,;64.83,-6.55,;66.33,-6.27,;67.07,-7.61,;66.02,-8.72,;64.64,-8.07,;63.41,-9.02,;63.82,-10.51,;61.89,-8.83,;60.94,-7.61,;61.13,-10.17,;59.59,-10.18,;58.81,-8.85,;58.82,-11.51,;57.28,-11.52,;59.6,-12.84,;58.84,-14.18,;66.31,-10.23,;65.14,-11.24,;67.76,-10.74,;68.05,-12.25,;66.74,-13.05,;65.39,-12.31,;64.07,-13.12,;64.11,-14.66,;65.47,-15.39,;66.78,-14.59,;69.4,-12.99,;69.43,-14.53,;70.78,-15.27,;72.1,-14.47,;72.06,-12.92,;70.71,-12.19,)| Show InChI InChI=1S/C62H80N12O8/c1-39(63-3)55(75)67-49-37-71(35-33-47-29-31-51(73(47)59(49)79)57(77)69-53(41-17-9-5-10-18-41)42-19-11-6-12-20-42)61(81)65-45-25-27-46(28-26-45)66-62(82)72-36-34-48-30-32-52(74(48)60(80)50(38-72)68-56(76)40(2)64-4)58(78)70-54(43-21-13-7-14-22-43)44-23-15-8-16-24-44/h5-24,39-40,45-54,63-64H,25-38H2,1-4H3,(H,65,81)(H,66,82)(H,67,75)(H,68,76)(H,69,77)(H,70,78)/t39-,40-,45-,46-,47+,48+,49-,50-,51-,52-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
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DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 1.70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Michigan
Curated by ChEMBL
| Assay Description
Binding affinity to XIAP linker BIR2-BIR3 domain (unknown origin) after 3 hrs by competitive fluorescence polarization assay in presence of Smac-1F |
J Med Chem 56: 3969-79 (2013)
Article DOI: 10.1021/jm400216d
BindingDB Entry DOI: 10.7270/Q2M61MNM |
More data for this
Ligand-Target Pair | |
Baculoviral IAP repeat-containing protein 3
(Homo sapiens (Human)) | BDBM50432759
(CHEMBL2348619)Show SMILES CN[C@@H](C)C(=O)N[C@H]1CN(CC[C@H]2CC[C@H](N2C1=O)C(=O)NC(c1ccccc1)c1ccccc1)C(=O)Nc1ccc(Oc2ccc(NC(=O)N3CC[C@H]4CC[C@H](N4C(=O)[C@H](C3)NC(=O)[C@H](C)NC)C(=O)NC(c3ccccc3)c3ccccc3)cc2)cc1 |r| Show InChI InChI=1S/C68H78N12O9/c1-43(69-3)61(81)73-55-41-77(39-37-51-29-35-57(79(51)65(55)85)63(83)75-59(45-17-9-5-10-18-45)46-19-11-6-12-20-46)67(87)71-49-25-31-53(32-26-49)89-54-33-27-50(28-34-54)72-68(88)78-40-38-52-30-36-58(80(52)66(86)56(42-78)74-62(82)44(2)70-4)64(84)76-60(47-21-13-7-14-22-47)48-23-15-8-16-24-48/h5-28,31-34,43-44,51-52,55-60,69-70H,29-30,35-42H2,1-4H3,(H,71,87)(H,72,88)(H,73,81)(H,74,82)(H,75,83)(H,76,84)/t43-,44-,51+,52+,55-,56-,57-,58-/m0/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 2.10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Michigan
Curated by ChEMBL
| Assay Description
Binding affinity to cIAP2 BIR3 domain (unknown origin) after 3 hrs by competitive fluorescence polarization assay in presence of Smac-2F |
J Med Chem 56: 3969-79 (2013)
Article DOI: 10.1021/jm400216d
BindingDB Entry DOI: 10.7270/Q2M61MNM |
More data for this
Ligand-Target Pair | |
Baculoviral IAP repeat-containing protein 2
(Homo sapiens (Human)) | BDBM50432763
(CHEMBL2348623)Show SMILES CN[C@@H](C)C(=O)N[C@H]1CN(CC[C@H]2CC[C@H](N2C1=O)C(=O)NC(c1ccccc1)c1ccccc1)C(=O)Nc1ccc(NC(=O)N2CC[C@H]3CC[C@H](N3C(=O)[C@H](C2)NC(=O)[C@H](C)NC)C(=O)NC(c2ccccc2)c2ccccc2)cc1 |r| Show InChI InChI=1S/C62H74N12O8/c1-39(63-3)55(75)67-49-37-71(35-33-47-29-31-51(73(47)59(49)79)57(77)69-53(41-17-9-5-10-18-41)42-19-11-6-12-20-42)61(81)65-45-25-27-46(28-26-45)66-62(82)72-36-34-48-30-32-52(74(48)60(80)50(38-72)68-56(76)40(2)64-4)58(78)70-54(43-21-13-7-14-22-43)44-23-15-8-16-24-44/h5-28,39-40,47-54,63-64H,29-38H2,1-4H3,(H,65,81)(H,66,82)(H,67,75)(H,68,76)(H,69,77)(H,70,78)/t39-,40-,47+,48+,49-,50-,51-,52-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 3.70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Michigan
Curated by ChEMBL
| Assay Description
Binding affinity to cIAP1 BIR3 domain (unknown origin) after 3 hrs by competitive fluorescence polarization assay in presence of Smac-2F |
J Med Chem 56: 3969-79 (2013)
Article DOI: 10.1021/jm400216d
BindingDB Entry DOI: 10.7270/Q2M61MNM |
More data for this
Ligand-Target Pair | |
Baculoviral IAP repeat-containing protein 2
(Homo sapiens (Human)) | BDBM50432756
(CHEMBL2348616)Show SMILES CN[C@@H](C)C(=O)N[C@H]1CN(CC[C@H]2CC[C@H](N2C1=O)C(=O)NC(c1ccccc1)c1ccccc1)C(=O)NCCCCNC(=O)N1CC[C@H]2CC[C@H](N2C(=O)[C@H](C1)NC(=O)[C@H](C)NC)C(=O)NC(c1ccccc1)c1ccccc1 |r| Show InChI InChI=1S/C60H78N12O8/c1-39(61-3)53(73)65-47-37-69(35-31-45-27-29-49(71(45)57(47)77)55(75)67-51(41-19-9-5-10-20-41)42-21-11-6-12-22-42)59(79)63-33-17-18-34-64-60(80)70-36-32-46-28-30-50(72(46)58(78)48(38-70)66-54(74)40(2)62-4)56(76)68-52(43-23-13-7-14-24-43)44-25-15-8-16-26-44/h5-16,19-26,39-40,45-52,61-62H,17-18,27-38H2,1-4H3,(H,63,79)(H,64,80)(H,65,73)(H,66,74)(H,67,75)(H,68,76)/t39-,40-,45+,46+,47-,48-,49-,50-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 3.90 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Michigan
Curated by ChEMBL
| Assay Description
Binding affinity to cIAP1 BIR3 domain (unknown origin) after 3 hrs by competitive fluorescence polarization assay in presence of Smac-2F |
J Med Chem 56: 3969-79 (2013)
Article DOI: 10.1021/jm400216d
BindingDB Entry DOI: 10.7270/Q2M61MNM |
More data for this
Ligand-Target Pair | |
Histamine H3 receptor
(Homo sapiens (Human)) | BDBM50493178
(CHEMBL2419581)Show InChI InChI=1S/C21H25N3O/c1-2-4-21-20(3-1)18(15-23-21)9-10-22-19-7-5-17(6-8-19)16-24-11-13-25-14-12-24/h1-8,15,22-23H,9-14,16H2 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 4.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Zhejiang University
Curated by ChEMBL
| Assay Description
Displacement of [3H]-(R)-alpha-methylhistamine from human histamine H3 receptor expressed in HEK293 cells after 90 to 120 mins by liquid scintillatio... |
Bioorg Med Chem 21: 5936-44 (2013)
Article DOI: 10.1016/j.bmc.2013.07.051
BindingDB Entry DOI: 10.7270/Q23X89K7 |
More data for this
Ligand-Target Pair | |
E3 ubiquitin-protein ligase XIAP
(Homo sapiens (Human)) | BDBM50432757
(CHEMBL2348617)Show SMILES CN[C@@H](C)C(=O)N[C@H]1CN(CC[C@H]2CC[C@H](N2C1=O)C(=O)NC(c1ccccc1)c1ccccc1)C(=O)N1CCN(CC1)C(=O)N1CC[C@H]2CC[C@H](N2C(=O)[C@H](C1)NC(=O)[C@H](C)NC)C(=O)NC(c1ccccc1)c1ccccc1 |r| Show InChI InChI=1S/C60H76N12O8/c1-39(61-3)53(73)63-47-37-69(31-29-45-25-27-49(71(45)57(47)77)55(75)65-51(41-17-9-5-10-18-41)42-19-11-6-12-20-42)59(79)67-33-35-68(36-34-67)60(80)70-32-30-46-26-28-50(72(46)58(78)48(38-70)64-54(74)40(2)62-4)56(76)66-52(43-21-13-7-14-22-43)44-23-15-8-16-24-44/h5-24,39-40,45-52,61-62H,25-38H2,1-4H3,(H,63,73)(H,64,74)(H,65,75)(H,66,76)/t39-,40-,45+,46+,47-,48-,49-,50-/m0/s1 | PDB
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| 4.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Michigan
Curated by ChEMBL
| Assay Description
Binding affinity to XIAP linker BIR2-BIR3 domain (unknown origin) after 3 hrs by competitive fluorescence polarization assay in presence of Smac-1F |
J Med Chem 56: 3969-79 (2013)
Article DOI: 10.1021/jm400216d
BindingDB Entry DOI: 10.7270/Q2M61MNM |
More data for this
Ligand-Target Pair | |
Baculoviral IAP repeat-containing protein 2
(Homo sapiens (Human)) | BDBM50432761
(CHEMBL2348621)Show SMILES CN[C@@H](C)C(=O)N[C@H]1CN(CC[C@H]2CC[C@H](N2C1=O)C(=O)NC(c1ccccc1)c1ccccc1)C(=O)NCc1cccc(CNC(=O)N2CC[C@H]3CC[C@H](N3C(=O)[C@H](C2)NC(=O)[C@H](C)NC)C(=O)NC(c2ccccc2)c2ccccc2)c1 |r| Show InChI InChI=1S/C64H78N12O8/c1-41(65-3)57(77)69-51-39-73(34-32-49-28-30-53(75(49)61(51)81)59(79)71-55(45-20-9-5-10-21-45)46-22-11-6-12-23-46)63(83)67-37-43-18-17-19-44(36-43)38-68-64(84)74-35-33-50-29-31-54(76(50)62(82)52(40-74)70-58(78)42(2)66-4)60(80)72-56(47-24-13-7-14-25-47)48-26-15-8-16-27-48/h5-27,36,41-42,49-56,65-66H,28-35,37-40H2,1-4H3,(H,67,83)(H,68,84)(H,69,77)(H,70,78)(H,71,79)(H,72,80)/t41-,42-,49+,50+,51-,52-,53-,54-/m0/s1 | PDB
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PubMed
| 4.70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Michigan
Curated by ChEMBL
| Assay Description
Binding affinity to cIAP1 BIR3 domain (unknown origin) after 3 hrs by competitive fluorescence polarization assay in presence of Smac-2F |
J Med Chem 56: 3969-79 (2013)
Article DOI: 10.1021/jm400216d
BindingDB Entry DOI: 10.7270/Q2M61MNM |
More data for this
Ligand-Target Pair | |
Baculoviral IAP repeat-containing protein 2
(Homo sapiens (Human)) | BDBM50432760
(CHEMBL2348620)Show SMILES CN[C@@H](C)C(=O)N[C@H]1CN(CC[C@H]2CC[C@H](N2C1=O)C(=O)NC(c1ccccc1)c1ccccc1)C(=O)Nc1ccc(Cc2ccc(NC(=O)N3CC[C@H]4CC[C@H](N4C(=O)[C@H](C3)NC(=O)[C@H](C)NC)C(=O)NC(c3ccccc3)c3ccccc3)cc2)cc1 |r| Show InChI InChI=1S/C69H80N12O8/c1-44(70-3)62(82)74-56-42-78(39-37-54-33-35-58(80(54)66(56)86)64(84)76-60(48-17-9-5-10-18-48)49-19-11-6-12-20-49)68(88)72-52-29-25-46(26-30-52)41-47-27-31-53(32-28-47)73-69(89)79-40-38-55-34-36-59(81(55)67(87)57(43-79)75-63(83)45(2)71-4)65(85)77-61(50-21-13-7-14-22-50)51-23-15-8-16-24-51/h5-32,44-45,54-61,70-71H,33-43H2,1-4H3,(H,72,88)(H,73,89)(H,74,82)(H,75,83)(H,76,84)(H,77,85)/t44-,45-,54+,55+,56-,57-,58-,59-/m0/s1 | PDB
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PubMed
| 4.90 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Michigan
Curated by ChEMBL
| Assay Description
Binding affinity to cIAP1 BIR3 domain (unknown origin) after 3 hrs by competitive fluorescence polarization assay in presence of Smac-2F |
J Med Chem 56: 3969-79 (2013)
Article DOI: 10.1021/jm400216d
BindingDB Entry DOI: 10.7270/Q2M61MNM |
More data for this
Ligand-Target Pair | |
Baculoviral IAP repeat-containing protein 2
(Homo sapiens (Human)) | BDBM50432754
(CHEMBL2348614)Show SMILES CN[C@@H](C)C(=O)N[C@H]1CN(CC[C@H]2CC[C@H](N2C1=O)C(=O)NC(c1ccccc1)c1ccccc1)C(=O)Cc1ccc(CC(=O)N2CC[C@H]3CC[C@H](N3C(=O)[C@H](C2)NC(=O)[C@H](C)NC)C(=O)NC(c2ccccc2)c2ccccc2)cc1 |r| Show InChI InChI=1S/C64H76N10O8/c1-41(65-3)59(77)67-51-39-71(35-33-49-29-31-53(73(49)63(51)81)61(79)69-57(45-17-9-5-10-18-45)46-19-11-6-12-20-46)55(75)37-43-25-27-44(28-26-43)38-56(76)72-36-34-50-30-32-54(74(50)64(82)52(40-72)68-60(78)42(2)66-4)62(80)70-58(47-21-13-7-14-22-47)48-23-15-8-16-24-48/h5-28,41-42,49-54,57-58,65-66H,29-40H2,1-4H3,(H,67,77)(H,68,78)(H,69,79)(H,70,80)/t41-,42-,49+,50+,51-,52-,53-,54-/m0/s1 | PDB
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PubMed
| 5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Michigan
Curated by ChEMBL
| Assay Description
Binding affinity to cIAP1 BIR3 domain (unknown origin) after 3 hrs by competitive fluorescence polarization assay in presence of Smac-2F |
J Med Chem 56: 3969-79 (2013)
Article DOI: 10.1021/jm400216d
BindingDB Entry DOI: 10.7270/Q2M61MNM |
More data for this
Ligand-Target Pair | |
Baculoviral IAP repeat-containing protein 3
(Homo sapiens (Human)) | BDBM50432763
(CHEMBL2348623)Show SMILES CN[C@@H](C)C(=O)N[C@H]1CN(CC[C@H]2CC[C@H](N2C1=O)C(=O)NC(c1ccccc1)c1ccccc1)C(=O)Nc1ccc(NC(=O)N2CC[C@H]3CC[C@H](N3C(=O)[C@H](C2)NC(=O)[C@H](C)NC)C(=O)NC(c2ccccc2)c2ccccc2)cc1 |r| Show InChI InChI=1S/C62H74N12O8/c1-39(63-3)55(75)67-49-37-71(35-33-47-29-31-51(73(47)59(49)79)57(77)69-53(41-17-9-5-10-18-41)42-19-11-6-12-20-42)61(81)65-45-25-27-46(28-26-45)66-62(82)72-36-34-48-30-32-52(74(48)60(80)50(38-72)68-56(76)40(2)64-4)58(78)70-54(43-21-13-7-14-22-43)44-23-15-8-16-24-44/h5-28,39-40,47-54,63-64H,29-38H2,1-4H3,(H,65,81)(H,66,82)(H,67,75)(H,68,76)(H,69,77)(H,70,78)/t39-,40-,47+,48+,49-,50-,51-,52-/m0/s1 | PDB
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PubMed
| 5.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Michigan
Curated by ChEMBL
| Assay Description
Binding affinity to cIAP2 BIR3 domain (unknown origin) after 3 hrs by competitive fluorescence polarization assay in presence of Smac-2F |
J Med Chem 56: 3969-79 (2013)
Article DOI: 10.1021/jm400216d
BindingDB Entry DOI: 10.7270/Q2M61MNM |
More data for this
Ligand-Target Pair | |
Baculoviral IAP repeat-containing protein 2
(Homo sapiens (Human)) | BDBM50432758
(CHEMBL2348618)Show SMILES CN[C@@H](C)C(=O)N[C@H]1CN(CC[C@H]2CC[C@H](N2C1=O)C(=O)NC(c1ccccc1)c1ccccc1)C(=O)N[C@H]1CC[C@@H](CC1)NC(=O)N1CC[C@H]2CC[C@H](N2C(=O)[C@H](C1)NC(=O)[C@H](C)NC)C(=O)NC(c1ccccc1)c1ccccc1 |r,wU:38.41,50.59,53.72,57.65,62.69,wD:41.48,12.16,7.6,2.2,15.20,(49.77,-12.92,;51.31,-12.89,;52.07,-11.55,;53.61,-11.53,;51.28,-10.23,;52.03,-8.88,;49.74,-10.25,;48.95,-8.93,;49.87,-7.69,;49.64,-6.16,;48.41,-5.25,;46.89,-5.47,;45.97,-6.7,;44.45,-6.45,;43.73,-7.81,;44.81,-8.91,;46.19,-8.23,;47.42,-9.15,;47.04,-10.64,;44.55,-10.43,;45.74,-11.42,;43.11,-10.97,;41.77,-10.2,;41.77,-8.66,;43.1,-7.89,;43.1,-6.35,;41.77,-5.58,;40.44,-6.36,;40.44,-7.9,;40.45,-10.97,;39.12,-10.19,;37.79,-10.96,;37.78,-12.5,;39.14,-13.28,;40.46,-12.5,;50.97,-5.37,;50.95,-3.83,;52.31,-6.12,;53.85,-6.12,;54.61,-4.79,;56.15,-4.78,;56.92,-6.12,;56.15,-7.44,;54.62,-7.44,;58.46,-6.12,;59.79,-5.33,;59.79,-3.79,;61.13,-6.09,;62.36,-5.14,;63.88,-5.33,;64.83,-6.55,;66.33,-6.27,;67.07,-7.61,;66.02,-8.72,;64.64,-8.07,;63.41,-9.02,;63.82,-10.51,;61.89,-8.83,;60.94,-7.61,;61.13,-10.17,;59.59,-10.18,;58.81,-8.85,;58.82,-11.51,;57.28,-11.52,;59.6,-12.84,;58.84,-14.18,;66.31,-10.23,;65.14,-11.24,;67.76,-10.74,;68.05,-12.25,;66.74,-13.05,;65.39,-12.31,;64.07,-13.12,;64.11,-14.66,;65.47,-15.39,;66.78,-14.59,;69.4,-12.99,;69.43,-14.53,;70.78,-15.27,;72.1,-14.47,;72.06,-12.92,;70.71,-12.19,)| Show InChI InChI=1S/C62H80N12O8/c1-39(63-3)55(75)67-49-37-71(35-33-47-29-31-51(73(47)59(49)79)57(77)69-53(41-17-9-5-10-18-41)42-19-11-6-12-20-42)61(81)65-45-25-27-46(28-26-45)66-62(82)72-36-34-48-30-32-52(74(48)60(80)50(38-72)68-56(76)40(2)64-4)58(78)70-54(43-21-13-7-14-22-43)44-23-15-8-16-24-44/h5-24,39-40,45-54,63-64H,25-38H2,1-4H3,(H,65,81)(H,66,82)(H,67,75)(H,68,76)(H,69,77)(H,70,78)/t39-,40-,45-,46-,47+,48+,49-,50-,51-,52-/m0/s1 | PDB
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PubMed
| 5.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Michigan
Curated by ChEMBL
| Assay Description
Binding affinity to cIAP1 BIR3 domain (unknown origin) after 3 hrs by competitive fluorescence polarization assay in presence of Smac-2F |
J Med Chem 56: 3969-79 (2013)
Article DOI: 10.1021/jm400216d
BindingDB Entry DOI: 10.7270/Q2M61MNM |
More data for this
Ligand-Target Pair | |
Baculoviral IAP repeat-containing protein 2
(Homo sapiens (Human)) | BDBM50432757
(CHEMBL2348617)Show SMILES CN[C@@H](C)C(=O)N[C@H]1CN(CC[C@H]2CC[C@H](N2C1=O)C(=O)NC(c1ccccc1)c1ccccc1)C(=O)N1CCN(CC1)C(=O)N1CC[C@H]2CC[C@H](N2C(=O)[C@H](C1)NC(=O)[C@H](C)NC)C(=O)NC(c1ccccc1)c1ccccc1 |r| Show InChI InChI=1S/C60H76N12O8/c1-39(61-3)53(73)63-47-37-69(31-29-45-25-27-49(71(45)57(47)77)55(75)65-51(41-17-9-5-10-18-41)42-19-11-6-12-20-42)59(79)67-33-35-68(36-34-67)60(80)70-32-30-46-26-28-50(72(46)58(78)48(38-70)64-54(74)40(2)62-4)56(76)66-52(43-21-13-7-14-22-43)44-23-15-8-16-24-44/h5-24,39-40,45-52,61-62H,25-38H2,1-4H3,(H,63,73)(H,64,74)(H,65,75)(H,66,76)/t39-,40-,45+,46+,47-,48-,49-,50-/m0/s1 | PDB
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PubMed
| 5.80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Michigan
Curated by ChEMBL
| Assay Description
Binding affinity to cIAP1 BIR3 domain (unknown origin) after 3 hrs by competitive fluorescence polarization assay in presence of Smac-2F |
J Med Chem 56: 3969-79 (2013)
Article DOI: 10.1021/jm400216d
BindingDB Entry DOI: 10.7270/Q2M61MNM |
More data for this
Ligand-Target Pair | |
Baculoviral IAP repeat-containing protein 2
(Homo sapiens (Human)) | BDBM50432762
(CHEMBL2348622)Show SMILES CN[C@@H](C)C(=O)N[C@H]1CN(CC[C@H]2CC[C@H](N2C1=O)C(=O)NC(c1ccccc1)c1ccccc1)C(=O)Nc1cccc(NC(=O)N2CC[C@H]3CC[C@H](N3C(=O)[C@H](C2)NC(=O)[C@H](C)NC)C(=O)NC(c2ccccc2)c2ccccc2)c1 |r| Show InChI InChI=1S/C62H74N12O8/c1-39(63-3)55(75)67-49-37-71(34-32-47-28-30-51(73(47)59(49)79)57(77)69-53(41-18-9-5-10-19-41)42-20-11-6-12-21-42)61(81)65-45-26-17-27-46(36-45)66-62(82)72-35-33-48-29-31-52(74(48)60(80)50(38-72)68-56(76)40(2)64-4)58(78)70-54(43-22-13-7-14-23-43)44-24-15-8-16-25-44/h5-27,36,39-40,47-54,63-64H,28-35,37-38H2,1-4H3,(H,65,81)(H,66,82)(H,67,75)(H,68,76)(H,69,77)(H,70,78)/t39-,40-,47+,48+,49-,50-,51-,52-/m0/s1 | PDB
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| Article
PubMed
| 7.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Michigan
Curated by ChEMBL
| Assay Description
Binding affinity to cIAP1 BIR3 domain (unknown origin) after 3 hrs by competitive fluorescence polarization assay in presence of Smac-2F |
J Med Chem 56: 3969-79 (2013)
Article DOI: 10.1021/jm400216d
BindingDB Entry DOI: 10.7270/Q2M61MNM |
More data for this
Ligand-Target Pair | |
Baculoviral IAP repeat-containing protein 3
(Homo sapiens (Human)) | BDBM50432756
(CHEMBL2348616)Show SMILES CN[C@@H](C)C(=O)N[C@H]1CN(CC[C@H]2CC[C@H](N2C1=O)C(=O)NC(c1ccccc1)c1ccccc1)C(=O)NCCCCNC(=O)N1CC[C@H]2CC[C@H](N2C(=O)[C@H](C1)NC(=O)[C@H](C)NC)C(=O)NC(c1ccccc1)c1ccccc1 |r| Show InChI InChI=1S/C60H78N12O8/c1-39(61-3)53(73)65-47-37-69(35-31-45-27-29-49(71(45)57(47)77)55(75)67-51(41-19-9-5-10-20-41)42-21-11-6-12-22-42)59(79)63-33-17-18-34-64-60(80)70-36-32-46-28-30-50(72(46)58(78)48(38-70)66-54(74)40(2)62-4)56(76)68-52(43-23-13-7-14-24-43)44-25-15-8-16-26-44/h5-16,19-26,39-40,45-52,61-62H,17-18,27-38H2,1-4H3,(H,63,79)(H,64,80)(H,65,73)(H,66,74)(H,67,75)(H,68,76)/t39-,40-,45+,46+,47-,48-,49-,50-/m0/s1 | PDB
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| Article
PubMed
| 7.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Michigan
Curated by ChEMBL
| Assay Description
Binding affinity to cIAP2 BIR3 domain (unknown origin) after 3 hrs by competitive fluorescence polarization assay in presence of Smac-2F |
J Med Chem 56: 3969-79 (2013)
Article DOI: 10.1021/jm400216d
BindingDB Entry DOI: 10.7270/Q2M61MNM |
More data for this
Ligand-Target Pair | |
Baculoviral IAP repeat-containing protein 3
(Homo sapiens (Human)) | BDBM50432761
(CHEMBL2348621)Show SMILES CN[C@@H](C)C(=O)N[C@H]1CN(CC[C@H]2CC[C@H](N2C1=O)C(=O)NC(c1ccccc1)c1ccccc1)C(=O)NCc1cccc(CNC(=O)N2CC[C@H]3CC[C@H](N3C(=O)[C@H](C2)NC(=O)[C@H](C)NC)C(=O)NC(c2ccccc2)c2ccccc2)c1 |r| Show InChI InChI=1S/C64H78N12O8/c1-41(65-3)57(77)69-51-39-73(34-32-49-28-30-53(75(49)61(51)81)59(79)71-55(45-20-9-5-10-21-45)46-22-11-6-12-23-46)63(83)67-37-43-18-17-19-44(36-43)38-68-64(84)74-35-33-50-29-31-54(76(50)62(82)52(40-74)70-58(78)42(2)66-4)60(80)72-56(47-24-13-7-14-25-47)48-26-15-8-16-27-48/h5-27,36,41-42,49-56,65-66H,28-35,37-40H2,1-4H3,(H,67,83)(H,68,84)(H,69,77)(H,70,78)(H,71,79)(H,72,80)/t41-,42-,49+,50+,51-,52-,53-,54-/m0/s1 | PDB
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PC cid
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UniChem
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| Article
PubMed
| 7.70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Michigan
Curated by ChEMBL
| Assay Description
Binding affinity to cIAP2 BIR3 domain (unknown origin) after 3 hrs by competitive fluorescence polarization assay in presence of Smac-2F |
J Med Chem 56: 3969-79 (2013)
Article DOI: 10.1021/jm400216d
BindingDB Entry DOI: 10.7270/Q2M61MNM |
More data for this
Ligand-Target Pair | |
Baculoviral IAP repeat-containing protein 3
(Homo sapiens (Human)) | BDBM50432754
(CHEMBL2348614)Show SMILES CN[C@@H](C)C(=O)N[C@H]1CN(CC[C@H]2CC[C@H](N2C1=O)C(=O)NC(c1ccccc1)c1ccccc1)C(=O)Cc1ccc(CC(=O)N2CC[C@H]3CC[C@H](N3C(=O)[C@H](C2)NC(=O)[C@H](C)NC)C(=O)NC(c2ccccc2)c2ccccc2)cc1 |r| Show InChI InChI=1S/C64H76N10O8/c1-41(65-3)59(77)67-51-39-71(35-33-49-29-31-53(73(49)63(51)81)61(79)69-57(45-17-9-5-10-18-45)46-19-11-6-12-20-46)55(75)37-43-25-27-44(28-26-43)38-56(76)72-36-34-50-30-32-54(74(50)64(82)52(40-72)68-60(78)42(2)66-4)62(80)70-58(47-21-13-7-14-22-47)48-23-15-8-16-24-48/h5-28,41-42,49-54,57-58,65-66H,29-40H2,1-4H3,(H,67,77)(H,68,78)(H,69,79)(H,70,80)/t41-,42-,49+,50+,51-,52-,53-,54-/m0/s1 | PDB
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PubMed
| 7.90 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Michigan
Curated by ChEMBL
| Assay Description
Binding affinity to cIAP2 BIR3 domain (unknown origin) after 3 hrs by competitive fluorescence polarization assay in presence of Smac-2F |
J Med Chem 56: 3969-79 (2013)
Article DOI: 10.1021/jm400216d
BindingDB Entry DOI: 10.7270/Q2M61MNM |
More data for this
Ligand-Target Pair | |
Baculoviral IAP repeat-containing protein 2
(Homo sapiens (Human)) | BDBM50432755
(CHEMBL2348615)Show SMILES CN[C@@H](C)C(=O)N[C@H]1CN(CC[C@H]2CC[C@H](N2C1=O)C(=O)NC(c1ccccc1)c1ccccc1)C(=O)NCCCCCCCCNC(=O)N1CC[C@H]2CC[C@H](N2C(=O)[C@H](C1)NC(=O)[C@H](C)NC)C(=O)NC(c1ccccc1)c1ccccc1 |r| Show InChI InChI=1S/C64H86N12O8/c1-43(65-3)57(77)69-51-41-73(39-35-49-31-33-53(75(49)61(51)81)59(79)71-55(45-23-13-9-14-24-45)46-25-15-10-16-26-46)63(83)67-37-21-7-5-6-8-22-38-68-64(84)74-40-36-50-32-34-54(76(50)62(82)52(42-74)70-58(78)44(2)66-4)60(80)72-56(47-27-17-11-18-28-47)48-29-19-12-20-30-48/h9-20,23-30,43-44,49-56,65-66H,5-8,21-22,31-42H2,1-4H3,(H,67,83)(H,68,84)(H,69,77)(H,70,78)(H,71,79)(H,72,80)/t43-,44-,49+,50+,51-,52-,53-,54-/m0/s1 | PDB
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| Article
PubMed
| 8.70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Michigan
Curated by ChEMBL
| Assay Description
Binding affinity to cIAP1 BIR3 domain (unknown origin) after 3 hrs by competitive fluorescence polarization assay in presence of Smac-2F |
J Med Chem 56: 3969-79 (2013)
Article DOI: 10.1021/jm400216d
BindingDB Entry DOI: 10.7270/Q2M61MNM |
More data for this
Ligand-Target Pair | |
Baculoviral IAP repeat-containing protein 3
(Homo sapiens (Human)) | BDBM50432760
(CHEMBL2348620)Show SMILES CN[C@@H](C)C(=O)N[C@H]1CN(CC[C@H]2CC[C@H](N2C1=O)C(=O)NC(c1ccccc1)c1ccccc1)C(=O)Nc1ccc(Cc2ccc(NC(=O)N3CC[C@H]4CC[C@H](N4C(=O)[C@H](C3)NC(=O)[C@H](C)NC)C(=O)NC(c3ccccc3)c3ccccc3)cc2)cc1 |r| Show InChI InChI=1S/C69H80N12O8/c1-44(70-3)62(82)74-56-42-78(39-37-54-33-35-58(80(54)66(56)86)64(84)76-60(48-17-9-5-10-18-48)49-19-11-6-12-20-49)68(88)72-52-29-25-46(26-30-52)41-47-27-31-53(32-28-47)73-69(89)79-40-38-55-34-36-59(81(55)67(87)57(43-79)75-63(83)45(2)71-4)65(85)77-61(50-21-13-7-14-22-50)51-23-15-8-16-24-51/h5-32,44-45,54-61,70-71H,33-43H2,1-4H3,(H,72,88)(H,73,89)(H,74,82)(H,75,83)(H,76,84)(H,77,85)/t44-,45-,54+,55+,56-,57-,58-,59-/m0/s1 | PDB
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PubMed
| 9.90 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Michigan
Curated by ChEMBL
| Assay Description
Binding affinity to cIAP2 BIR3 domain (unknown origin) after 3 hrs by competitive fluorescence polarization assay in presence of Smac-2F |
J Med Chem 56: 3969-79 (2013)
Article DOI: 10.1021/jm400216d
BindingDB Entry DOI: 10.7270/Q2M61MNM |
More data for this
Ligand-Target Pair | |
Baculoviral IAP repeat-containing protein 3
(Homo sapiens (Human)) | BDBM50432758
(CHEMBL2348618)Show SMILES CN[C@@H](C)C(=O)N[C@H]1CN(CC[C@H]2CC[C@H](N2C1=O)C(=O)NC(c1ccccc1)c1ccccc1)C(=O)N[C@H]1CC[C@@H](CC1)NC(=O)N1CC[C@H]2CC[C@H](N2C(=O)[C@H](C1)NC(=O)[C@H](C)NC)C(=O)NC(c1ccccc1)c1ccccc1 |r,wU:38.41,50.59,53.72,57.65,62.69,wD:41.48,12.16,7.6,2.2,15.20,(49.77,-12.92,;51.31,-12.89,;52.07,-11.55,;53.61,-11.53,;51.28,-10.23,;52.03,-8.88,;49.74,-10.25,;48.95,-8.93,;49.87,-7.69,;49.64,-6.16,;48.41,-5.25,;46.89,-5.47,;45.97,-6.7,;44.45,-6.45,;43.73,-7.81,;44.81,-8.91,;46.19,-8.23,;47.42,-9.15,;47.04,-10.64,;44.55,-10.43,;45.74,-11.42,;43.11,-10.97,;41.77,-10.2,;41.77,-8.66,;43.1,-7.89,;43.1,-6.35,;41.77,-5.58,;40.44,-6.36,;40.44,-7.9,;40.45,-10.97,;39.12,-10.19,;37.79,-10.96,;37.78,-12.5,;39.14,-13.28,;40.46,-12.5,;50.97,-5.37,;50.95,-3.83,;52.31,-6.12,;53.85,-6.12,;54.61,-4.79,;56.15,-4.78,;56.92,-6.12,;56.15,-7.44,;54.62,-7.44,;58.46,-6.12,;59.79,-5.33,;59.79,-3.79,;61.13,-6.09,;62.36,-5.14,;63.88,-5.33,;64.83,-6.55,;66.33,-6.27,;67.07,-7.61,;66.02,-8.72,;64.64,-8.07,;63.41,-9.02,;63.82,-10.51,;61.89,-8.83,;60.94,-7.61,;61.13,-10.17,;59.59,-10.18,;58.81,-8.85,;58.82,-11.51,;57.28,-11.52,;59.6,-12.84,;58.84,-14.18,;66.31,-10.23,;65.14,-11.24,;67.76,-10.74,;68.05,-12.25,;66.74,-13.05,;65.39,-12.31,;64.07,-13.12,;64.11,-14.66,;65.47,-15.39,;66.78,-14.59,;69.4,-12.99,;69.43,-14.53,;70.78,-15.27,;72.1,-14.47,;72.06,-12.92,;70.71,-12.19,)| Show InChI InChI=1S/C62H80N12O8/c1-39(63-3)55(75)67-49-37-71(35-33-47-29-31-51(73(47)59(49)79)57(77)69-53(41-17-9-5-10-18-41)42-19-11-6-12-20-42)61(81)65-45-25-27-46(28-26-45)66-62(82)72-36-34-48-30-32-52(74(48)60(80)50(38-72)68-56(76)40(2)64-4)58(78)70-54(43-21-13-7-14-22-43)44-23-15-8-16-24-44/h5-24,39-40,45-54,63-64H,25-38H2,1-4H3,(H,65,81)(H,66,82)(H,67,75)(H,68,76)(H,69,77)(H,70,78)/t39-,40-,45-,46-,47+,48+,49-,50-,51-,52-/m0/s1 | PDB
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PubMed
| 10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Michigan
Curated by ChEMBL
| Assay Description
Binding affinity to cIAP2 BIR3 domain (unknown origin) after 3 hrs by competitive fluorescence polarization assay in presence of Smac-2F |
J Med Chem 56: 3969-79 (2013)
Article DOI: 10.1021/jm400216d
BindingDB Entry DOI: 10.7270/Q2M61MNM |
More data for this
Ligand-Target Pair | |
Baculoviral IAP repeat-containing protein 3
(Homo sapiens (Human)) | BDBM50432757
(CHEMBL2348617)Show SMILES CN[C@@H](C)C(=O)N[C@H]1CN(CC[C@H]2CC[C@H](N2C1=O)C(=O)NC(c1ccccc1)c1ccccc1)C(=O)N1CCN(CC1)C(=O)N1CC[C@H]2CC[C@H](N2C(=O)[C@H](C1)NC(=O)[C@H](C)NC)C(=O)NC(c1ccccc1)c1ccccc1 |r| Show InChI InChI=1S/C60H76N12O8/c1-39(61-3)53(73)63-47-37-69(31-29-45-25-27-49(71(45)57(47)77)55(75)65-51(41-17-9-5-10-18-41)42-19-11-6-12-20-42)59(79)67-33-35-68(36-34-67)60(80)70-32-30-46-26-28-50(72(46)58(78)48(38-70)64-54(74)40(2)62-4)56(76)66-52(43-21-13-7-14-22-43)44-23-15-8-16-24-44/h5-24,39-40,45-52,61-62H,25-38H2,1-4H3,(H,63,73)(H,64,74)(H,65,75)(H,66,76)/t39-,40-,45+,46+,47-,48-,49-,50-/m0/s1 | PDB
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PubMed
| 11 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Michigan
Curated by ChEMBL
| Assay Description
Binding affinity to cIAP2 BIR3 domain (unknown origin) after 3 hrs by competitive fluorescence polarization assay in presence of Smac-2F |
J Med Chem 56: 3969-79 (2013)
Article DOI: 10.1021/jm400216d
BindingDB Entry DOI: 10.7270/Q2M61MNM |
More data for this
Ligand-Target Pair | |
Baculoviral IAP repeat-containing protein 3
(Homo sapiens (Human)) | BDBM50432755
(CHEMBL2348615)Show SMILES CN[C@@H](C)C(=O)N[C@H]1CN(CC[C@H]2CC[C@H](N2C1=O)C(=O)NC(c1ccccc1)c1ccccc1)C(=O)NCCCCCCCCNC(=O)N1CC[C@H]2CC[C@H](N2C(=O)[C@H](C1)NC(=O)[C@H](C)NC)C(=O)NC(c1ccccc1)c1ccccc1 |r| Show InChI InChI=1S/C64H86N12O8/c1-43(65-3)57(77)69-51-41-73(39-35-49-31-33-53(75(49)61(51)81)59(79)71-55(45-23-13-9-14-24-45)46-25-15-10-16-26-46)63(83)67-37-21-7-5-6-8-22-38-68-64(84)74-40-36-50-32-34-54(76(50)62(82)52(42-74)70-58(78)44(2)66-4)60(80)72-56(47-27-17-11-18-28-47)48-29-19-12-20-30-48/h9-20,23-30,43-44,49-56,65-66H,5-8,21-22,31-42H2,1-4H3,(H,67,83)(H,68,84)(H,69,77)(H,70,78)(H,71,79)(H,72,80)/t43-,44-,49+,50+,51-,52-,53-,54-/m0/s1 | PDB
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PubMed
| 13 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Michigan
Curated by ChEMBL
| Assay Description
Binding affinity to cIAP2 BIR3 domain (unknown origin) after 3 hrs by competitive fluorescence polarization assay in presence of Smac-2F |
J Med Chem 56: 3969-79 (2013)
Article DOI: 10.1021/jm400216d
BindingDB Entry DOI: 10.7270/Q2M61MNM |
More data for this
Ligand-Target Pair | |
Baculoviral IAP repeat-containing protein 3
(Homo sapiens (Human)) | BDBM50432762
(CHEMBL2348622)Show SMILES CN[C@@H](C)C(=O)N[C@H]1CN(CC[C@H]2CC[C@H](N2C1=O)C(=O)NC(c1ccccc1)c1ccccc1)C(=O)Nc1cccc(NC(=O)N2CC[C@H]3CC[C@H](N3C(=O)[C@H](C2)NC(=O)[C@H](C)NC)C(=O)NC(c2ccccc2)c2ccccc2)c1 |r| Show InChI InChI=1S/C62H74N12O8/c1-39(63-3)55(75)67-49-37-71(34-32-47-28-30-51(73(47)59(49)79)57(77)69-53(41-18-9-5-10-19-41)42-20-11-6-12-21-42)61(81)65-45-26-17-27-46(36-45)66-62(82)72-35-33-48-29-31-52(74(48)60(80)50(38-72)68-56(76)40(2)64-4)58(78)70-54(43-22-13-7-14-23-43)44-24-15-8-16-25-44/h5-27,36,39-40,47-54,63-64H,28-35,37-38H2,1-4H3,(H,65,81)(H,66,82)(H,67,75)(H,68,76)(H,69,77)(H,70,78)/t39-,40-,47+,48+,49-,50-,51-,52-/m0/s1 | PDB
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PubMed
| 13 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Michigan
Curated by ChEMBL
| Assay Description
Binding affinity to cIAP2 BIR3 domain (unknown origin) after 3 hrs by competitive fluorescence polarization assay in presence of Smac-2F |
J Med Chem 56: 3969-79 (2013)
Article DOI: 10.1021/jm400216d
BindingDB Entry DOI: 10.7270/Q2M61MNM |
More data for this
Ligand-Target Pair | |
Baculoviral IAP repeat-containing protein 2
(Homo sapiens (Human)) | BDBM50432753
(CHEMBL2348613)Show SMILES CN[C@@H](C)C(=O)N[C@H]1CN(CC[C@H]2CC[C@H](N2C1=O)C(=O)NC(c1ccccc1)c1ccccc1)C(=O)CCc1ccc(CCC(=O)N2CC[C@H]3CC[C@H](N3C(=O)[C@H](C2)NC(=O)[C@H](C)NC)C(=O)NC(c2ccccc2)c2ccccc2)cc1 |r| Show InChI InChI=1S/C66H80N10O8/c1-43(67-3)61(79)69-53-41-73(39-37-51-31-33-55(75(51)65(53)83)63(81)71-59(47-17-9-5-10-18-47)48-19-11-6-12-20-48)57(77)35-29-45-25-27-46(28-26-45)30-36-58(78)74-40-38-52-32-34-56(76(52)66(84)54(42-74)70-62(80)44(2)68-4)64(82)72-60(49-21-13-7-14-22-49)50-23-15-8-16-24-50/h5-28,43-44,51-56,59-60,67-68H,29-42H2,1-4H3,(H,69,79)(H,70,80)(H,71,81)(H,72,82)/t43-,44-,51+,52+,53-,54-,55-,56-/m0/s1 | PDB
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PubMed
| 14 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Michigan
Curated by ChEMBL
| Assay Description
Binding affinity to cIAP1 BIR3 domain (unknown origin) after 3 hrs by competitive fluorescence polarization assay in presence of Smac-2F |
J Med Chem 56: 3969-79 (2013)
Article DOI: 10.1021/jm400216d
BindingDB Entry DOI: 10.7270/Q2M61MNM |
More data for this
Ligand-Target Pair | |
Baculoviral IAP repeat-containing protein 3
(Homo sapiens (Human)) | BDBM50432753
(CHEMBL2348613)Show SMILES CN[C@@H](C)C(=O)N[C@H]1CN(CC[C@H]2CC[C@H](N2C1=O)C(=O)NC(c1ccccc1)c1ccccc1)C(=O)CCc1ccc(CCC(=O)N2CC[C@H]3CC[C@H](N3C(=O)[C@H](C2)NC(=O)[C@H](C)NC)C(=O)NC(c2ccccc2)c2ccccc2)cc1 |r| Show InChI InChI=1S/C66H80N10O8/c1-43(67-3)61(79)69-53-41-73(39-37-51-31-33-55(75(51)65(53)83)63(81)71-59(47-17-9-5-10-18-47)48-19-11-6-12-20-48)57(77)35-29-45-25-27-46(28-26-45)30-36-58(78)74-40-38-52-32-34-56(76(52)66(84)54(42-74)70-62(80)44(2)68-4)64(82)72-60(49-21-13-7-14-22-49)50-23-15-8-16-24-50/h5-28,43-44,51-56,59-60,67-68H,29-42H2,1-4H3,(H,69,79)(H,70,80)(H,71,81)(H,72,82)/t43-,44-,51+,52+,53-,54-,55-,56-/m0/s1 | PDB
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PubMed
| 25 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Michigan
Curated by ChEMBL
| Assay Description
Binding affinity to cIAP2 BIR3 domain (unknown origin) after 3 hrs by competitive fluorescence polarization assay in presence of Smac-2F |
J Med Chem 56: 3969-79 (2013)
Article DOI: 10.1021/jm400216d
BindingDB Entry DOI: 10.7270/Q2M61MNM |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50040437
(CHEMBL3360608)Show SMILES COc1cc2c(Nc3cccc(c3)C#C)ncnc2cc1OCCCCn1ccnc1[N+]([O-])=O Show InChI InChI=1S/C24H22N6O4/c1-3-17-7-6-8-18(13-17)28-23-19-14-21(33-2)22(15-20(19)26-16-27-23)34-12-5-4-10-29-11-9-25-24(29)30(31)32/h1,6-9,11,13-16H,4-5,10,12H2,2H3,(H,26,27,28) | PDB
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| n/a | n/a | 0.260 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of wild type EGFR (unknown origin) by Z'-Lyte kinase assay |
Bioorg Med Chem 22: 6796-805 (2015)
Article DOI: 10.1016/j.bmc.2014.10.038
BindingDB Entry DOI: 10.7270/Q22J6DHQ |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50040432
(CHEMBL3360603)Show SMILES COc1cc2c(Nc3ccc(F)c(Cl)c3)ncnc2cc1OCCCCn1ccnc1[N+]([O-])=O Show InChI InChI=1S/C22H20ClFN6O4/c1-33-19-11-15-18(26-13-27-21(15)28-14-4-5-17(24)16(23)10-14)12-20(19)34-9-3-2-7-29-8-6-25-22(29)30(31)32/h4-6,8,10-13H,2-3,7,9H2,1H3,(H,26,27,28) | PDB
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| n/a | n/a | 0.310 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of wild type EGFR (unknown origin) by Z'-Lyte kinase assay |
Bioorg Med Chem 22: 6796-805 (2015)
Article DOI: 10.1016/j.bmc.2014.10.038
BindingDB Entry DOI: 10.7270/Q22J6DHQ |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Homo sapiens (Human)) | BDBM50521354
(CHEMBL4453364)Show SMILES C[C@H](Nc1ncnc(N)c1C#N)C1=Nc2cccc(Cl)c2S(=O)(=O)N1c1ccccc1 |r,t:13| Show InChI InChI=1S/C20H16ClN7O2S/c1-12(26-19-14(10-22)18(23)24-11-25-19)20-27-16-9-5-8-15(21)17(16)31(29,30)28(20)13-6-3-2-4-7-13/h2-9,11-12H,1H3,(H3,23,24,25,26)/t12-/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | <0.320 | n/a | n/a | n/a | n/a | n/a | n/a |
Zhejiang University
Curated by ChEMBL
| Assay Description
Inhibition of His-tagged recombinant human PI3K p110delta/p85alpha using lipid substrate incubated for 2 hrs by ADP-Glo assay |
Eur J Med Chem 170: 112-125 (2019)
Article DOI: 10.1016/j.ejmech.2019.03.005
BindingDB Entry DOI: 10.7270/Q2RF5ZF7 |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50040435
(CHEMBL3360606)Show SMILES COc1cc2c(Nc3ccc(F)c(Cl)c3)ncnc2cc1OCCOCCn1ccnc1[N+]([O-])=O Show InChI InChI=1S/C22H20ClFN6O5/c1-33-19-11-15-18(26-13-27-21(15)28-14-2-3-17(24)16(23)10-14)12-20(19)35-9-8-34-7-6-29-5-4-25-22(29)30(31)32/h2-5,10-13H,6-9H2,1H3,(H,26,27,28) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.320 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of wild type EGFR (unknown origin) by Z'-Lyte kinase assay |
Bioorg Med Chem 22: 6796-805 (2015)
Article DOI: 10.1016/j.bmc.2014.10.038
BindingDB Entry DOI: 10.7270/Q22J6DHQ |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50039330
(CHEMBL3355877)Show SMILES COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OCCCCCCn1ccnc1[N+]([O-])=O Show InChI InChI=1S/C24H24ClFN6O4/c1-35-21-14-20-17(23(29-15-28-20)30-16-6-7-19(26)18(25)12-16)13-22(21)36-11-5-3-2-4-9-31-10-8-27-24(31)32(33)34/h6-8,10,12-15H,2-5,9,11H2,1H3,(H,28,29,30) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 0.320 | n/a | n/a | n/a | n/a | n/a | n/a |
Zhejiang University
Curated by ChEMBL
| Assay Description
Inhibition of wild type EGFR (unknown origin) by Z'-Lyte kinase assay |
Eur J Med Chem 89: 826-34 (2014)
Article DOI: 10.1016/j.ejmech.2014.11.010
BindingDB Entry DOI: 10.7270/Q24F1SC5 |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50040449
(CHEMBL3360619)Show SMILES COc1cc2c(Nc3cccc(Br)c3)ncnc2cc1OCCCCCn1ccnc1[N+]([O-])=O Show InChI InChI=1S/C23H23BrN6O4/c1-33-20-13-18-19(26-15-27-22(18)28-17-7-5-6-16(24)12-17)14-21(20)34-11-4-2-3-9-29-10-8-25-23(29)30(31)32/h5-8,10,12-15H,2-4,9,11H2,1H3,(H,26,27,28) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.330 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of wild type EGFR (unknown origin) by Z'-Lyte kinase assay |
Bioorg Med Chem 22: 6796-805 (2015)
Article DOI: 10.1016/j.bmc.2014.10.038
BindingDB Entry DOI: 10.7270/Q22J6DHQ |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50040448
(CHEMBL3360618)Show SMILES COc1cc2c(Nc3cccc(Br)c3)ncnc2cc1OCCCCn1ccnc1[N+]([O-])=O Show InChI InChI=1S/C22H21BrN6O4/c1-32-19-12-17-18(25-14-26-21(17)27-16-6-4-5-15(23)11-16)13-20(19)33-10-3-2-8-28-9-7-24-22(28)29(30)31/h4-7,9,11-14H,2-3,8,10H2,1H3,(H,25,26,27) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 0.370 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of wild type EGFR (unknown origin) by Z'-Lyte kinase assay |
Bioorg Med Chem 22: 6796-805 (2015)
Article DOI: 10.1016/j.bmc.2014.10.038
BindingDB Entry DOI: 10.7270/Q22J6DHQ |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM5447
(CHEMBL939 | GEFITINIB | Iressa | N-(3-Chloro-4-flu...)Show SMILES COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OCCCN1CCOCC1 Show InChI InChI=1S/C22H24ClFN4O3/c1-29-20-13-19-16(12-21(20)31-8-2-5-28-6-9-30-10-7-28)22(26-14-25-19)27-15-3-4-18(24)17(23)11-15/h3-4,11-14H,2,5-10H2,1H3,(H,25,26,27) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
DrugBank
MCE
MMDB
PC cid
PC sid
PDB
UniChem
Patents
Similars
| DrugBank
MMDB
PDB
Article
PubMed
| n/a | n/a | 0.450 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of wild type EGFR (unknown origin) by Z'-Lyte kinase assay |
Bioorg Med Chem 22: 6796-805 (2015)
Article DOI: 10.1016/j.bmc.2014.10.038
BindingDB Entry DOI: 10.7270/Q22J6DHQ |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM5447
(CHEMBL939 | GEFITINIB | Iressa | N-(3-Chloro-4-flu...)Show SMILES COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OCCCN1CCOCC1 Show InChI InChI=1S/C22H24ClFN4O3/c1-29-20-13-19-16(12-21(20)31-8-2-5-28-6-9-30-10-7-28)22(26-14-25-19)27-15-3-4-18(24)17(23)11-15/h3-4,11-14H,2,5-10H2,1H3,(H,25,26,27) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
DrugBank
MCE
MMDB
PC cid
PC sid
PDB
UniChem
Patents
Similars
| DrugBank
MMDB
PDB
Article
PubMed
| n/a | n/a | 0.450 | n/a | n/a | n/a | n/a | n/a | n/a |
Zhejiang University
Curated by ChEMBL
| Assay Description
Inhibition of wild type EGFR (unknown origin) by Z'-Lyte kinase assay |
Eur J Med Chem 89: 826-34 (2014)
Article DOI: 10.1016/j.ejmech.2014.11.010
BindingDB Entry DOI: 10.7270/Q24F1SC5 |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Histamine H3 receptor
(Homo sapiens (Human)) | BDBM50562736
(CHEMBL4752329)Show SMILES COc1cn(ccc1=O)-c1ccc(OC2CCN(CC2)C2CCCC2)cc1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 0.460 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Antagonist activity at human histamine H3 receptor expressed in HEK293 cells preincubated for 5 mins followed by forskolin-stimulation and measured a... |
Citation and Details
Article DOI: 10.1016/j.ejmech.2020.113096
BindingDB Entry DOI: 10.7270/Q2T72N5B |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50039328
(CHEMBL3355875)Show SMILES COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OCCCCn1ccnc1[N+]([O-])=O Show InChI InChI=1S/C22H20ClFN6O4/c1-33-19-12-18-15(21(27-13-26-18)28-14-4-5-17(24)16(23)10-14)11-20(19)34-9-3-2-7-29-8-6-25-22(29)30(31)32/h4-6,8,10-13H,2-3,7,9H2,1H3,(H,26,27,28) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.470 | n/a | n/a | n/a | n/a | n/a | n/a |
Zhejiang University
Curated by ChEMBL
| Assay Description
Inhibition of wild type EGFR (unknown origin) by Z'-Lyte kinase assay |
Eur J Med Chem 89: 826-34 (2014)
Article DOI: 10.1016/j.ejmech.2014.11.010
BindingDB Entry DOI: 10.7270/Q24F1SC5 |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50040438
(CHEMBL3360609)Show SMILES COc1cc2c(Nc3cccc(c3)C#C)ncnc2cc1OCCCCCn1ccnc1[N+]([O-])=O Show InChI InChI=1S/C25H24N6O4/c1-3-18-8-7-9-19(14-18)29-24-20-15-22(34-2)23(16-21(20)27-17-28-24)35-13-6-4-5-11-30-12-10-26-25(30)31(32)33/h1,7-10,12,14-17H,4-6,11,13H2,2H3,(H,27,28,29) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 0.470 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of wild type EGFR (unknown origin) by Z'-Lyte kinase assay |
Bioorg Med Chem 22: 6796-805 (2015)
Article DOI: 10.1016/j.bmc.2014.10.038
BindingDB Entry DOI: 10.7270/Q22J6DHQ |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50040447
(CHEMBL3360617)Show SMILES COc1cc2c(Nc3cccc(Br)c3)ncnc2cc1OCCCn1ccnc1[N+]([O-])=O Show InChI InChI=1S/C21H19BrN6O4/c1-31-18-11-16-17(24-13-25-20(16)26-15-5-2-4-14(22)10-15)12-19(18)32-9-3-7-27-8-6-23-21(27)28(29)30/h2,4-6,8,10-13H,3,7,9H2,1H3,(H,24,25,26) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 0.490 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of wild type EGFR (unknown origin) by Z'-Lyte kinase assay |
Bioorg Med Chem 22: 6796-805 (2015)
Article DOI: 10.1016/j.bmc.2014.10.038
BindingDB Entry DOI: 10.7270/Q22J6DHQ |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50039334
(CHEMBL3355881)Show SMILES COc1cc2ncnc(Nc3cccc(c3)C#C)c2cc1OCCCCCn1ccnc1[N+]([O-])=O Show InChI InChI=1S/C25H24N6O4/c1-3-18-8-7-9-19(14-18)29-24-20-15-23(22(34-2)16-21(20)27-17-28-24)35-13-6-4-5-11-30-12-10-26-25(30)31(32)33/h1,7-10,12,14-17H,4-6,11,13H2,2H3,(H,27,28,29) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.490 | n/a | n/a | n/a | n/a | n/a | n/a |
Zhejiang University
Curated by ChEMBL
| Assay Description
Inhibition of wild type EGFR (unknown origin) by Z'-Lyte kinase assay |
Eur J Med Chem 89: 826-34 (2014)
Article DOI: 10.1016/j.ejmech.2014.11.010
BindingDB Entry DOI: 10.7270/Q24F1SC5 |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50039335
(CHEMBL3355882)Show SMILES COc1cc2ncnc(Nc3cccc(c3)C#C)c2cc1OCCCCCCn1ccnc1[N+]([O-])=O Show InChI InChI=1S/C26H26N6O4/c1-3-19-9-8-10-20(15-19)30-25-21-16-24(23(35-2)17-22(21)28-18-29-25)36-14-7-5-4-6-12-31-13-11-27-26(31)32(33)34/h1,8-11,13,15-18H,4-7,12,14H2,2H3,(H,28,29,30) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Zhejiang University
Curated by ChEMBL
| Assay Description
Inhibition of wild type EGFR (unknown origin) by Z'-Lyte kinase assay |
Eur J Med Chem 89: 826-34 (2014)
Article DOI: 10.1016/j.ejmech.2014.11.010
BindingDB Entry DOI: 10.7270/Q24F1SC5 |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50039329
(CHEMBL3355876)Show SMILES COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OCCCCCn1ccnc1[N+]([O-])=O Show InChI InChI=1S/C23H22ClFN6O4/c1-34-20-13-19-16(22(28-14-27-19)29-15-5-6-18(25)17(24)11-15)12-21(20)35-10-4-2-3-8-30-9-7-26-23(30)31(32)33/h5-7,9,11-14H,2-4,8,10H2,1H3,(H,27,28,29) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 0.510 | n/a | n/a | n/a | n/a | n/a | n/a |
Zhejiang University
Curated by ChEMBL
| Assay Description
Inhibition of wild type EGFR (unknown origin) by Z'-Lyte kinase assay |
Eur J Med Chem 89: 826-34 (2014)
Article DOI: 10.1016/j.ejmech.2014.11.010
BindingDB Entry DOI: 10.7270/Q24F1SC5 |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50040433
(CHEMBL3360604)Show SMILES COc1cc2c(Nc3ccc(F)c(Cl)c3)ncnc2cc1OCCCCCn1ccnc1[N+]([O-])=O Show InChI InChI=1S/C23H22ClFN6O4/c1-34-20-12-16-19(27-14-28-22(16)29-15-5-6-18(25)17(24)11-15)13-21(20)35-10-4-2-3-8-30-9-7-26-23(30)31(32)33/h5-7,9,11-14H,2-4,8,10H2,1H3,(H,27,28,29) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 0.520 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of wild type EGFR (unknown origin) by Z'-Lyte kinase assay |
Bioorg Med Chem 22: 6796-805 (2015)
Article DOI: 10.1016/j.bmc.2014.10.038
BindingDB Entry DOI: 10.7270/Q22J6DHQ |
More data for this
Ligand-Target Pair | |
Histamine H3 receptor
(Homo sapiens (Human)) | BDBM50562729
(CHEMBL4748265) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 0.520 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Antagonist activity at human histamine H3 receptor expressed in HEK293 cells preincubated for 5 mins followed by forskolin-stimulation and measured a... |
Citation and Details
Article DOI: 10.1016/j.ejmech.2020.113096
BindingDB Entry DOI: 10.7270/Q2T72N5B |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50039459
(CHEMBL3355889)Show SMILES COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OCCCCn1c(C)ncc1[N+]([O-])=O Show InChI InChI=1S/C23H22ClFN6O4/c1-14-26-12-22(31(32)33)30(14)7-3-4-8-35-21-10-16-19(11-20(21)34-2)27-13-28-23(16)29-15-5-6-18(25)17(24)9-15/h5-6,9-13H,3-4,7-8H2,1-2H3,(H,27,28,29) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.530 | n/a | n/a | n/a | n/a | n/a | n/a |
Zhejiang University
Curated by ChEMBL
| Assay Description
Inhibition of wild type EGFR (unknown origin) by Z'-Lyte kinase assay |
Eur J Med Chem 89: 826-34 (2014)
Article DOI: 10.1016/j.ejmech.2014.11.010
BindingDB Entry DOI: 10.7270/Q24F1SC5 |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50040441
(CHEMBL3360611)Show SMILES COc1cc2c(Nc3cccc(c3)C#C)ncnc2cc1OCCOCCn1ccnc1[N+]([O-])=O Show InChI InChI=1S/C24H22N6O5/c1-3-17-5-4-6-18(13-17)28-23-19-14-21(33-2)22(15-20(19)26-16-27-23)35-12-11-34-10-9-29-8-7-25-24(29)30(31)32/h1,4-8,13-16H,9-12H2,2H3,(H,26,27,28) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.540 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of wild type EGFR (unknown origin) by Z'-Lyte kinase assay |
Bioorg Med Chem 22: 6796-805 (2015)
Article DOI: 10.1016/j.bmc.2014.10.038
BindingDB Entry DOI: 10.7270/Q22J6DHQ |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50039333
(CHEMBL3355880)Show SMILES COc1cc2ncnc(Nc3cccc(c3)C#C)c2cc1OCCCCn1ccnc1[N+]([O-])=O Show InChI InChI=1S/C24H22N6O4/c1-3-17-7-6-8-18(13-17)28-23-19-14-22(21(33-2)15-20(19)26-16-27-23)34-12-5-4-10-29-11-9-25-24(29)30(31)32/h1,6-9,11,13-16H,4-5,10,12H2,2H3,(H,26,27,28) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 0.560 | n/a | n/a | n/a | n/a | n/a | n/a |
Zhejiang University
Curated by ChEMBL
| Assay Description
Inhibition of wild type EGFR (unknown origin) by Z'-Lyte kinase assay |
Eur J Med Chem 89: 826-34 (2014)
Article DOI: 10.1016/j.ejmech.2014.11.010
BindingDB Entry DOI: 10.7270/Q24F1SC5 |
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Ligand-Target Pair | |
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