Compile Data Set for Download or QSAR

Found 358 hits with Last Name = 'shibata' and Initial = 'k'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM182767 (US9145414, 17 | US9145414, 9) Show SMILES CCn1ccc2c(Nc3nc(N[C@@H]4CCCC[C@@H]4N)nnc3C(N)=O)cccc12 |r| Show InChI InChI=1S/C20H26N8O/c1-2-28-11-10-12-14(8-5-9-16(12)28)23-19-17(18(22)29)26-27-20(25-19)24-15-7-4-3-6-13(15)21/h5,8-11,13,15H,2-4,6-7,21H2,1H3,(H2,22,29)(H2,23,24,25,27)/t13-,15+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.210	n/a	n/a	n/a	n/a	7.5	25
TAIHO PHARMACEUTICAL CO., LTD. US Patent					Assay Description The in vitro inhibitory activity of the compound of the present invention against Syk kinase activity was assayed under the following conditions: the...				US Patent US9145414 (2015) BindingDB Entry DOI: 10.7270/Q2513X18
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM182770 (US9145414, 26) Show SMILES N[C@H]1CCCC[C@H]1Nc1nnc(C(N)=O)c(Nc2cccc3n(ccc23)C(F)F)n1 |r| Show InChI InChI=1S/C19H22F2N8O/c20-18(21)29-9-8-10-12(6-3-7-14(10)29)24-17-15(16(23)30)27-28-19(26-17)25-13-5-2-1-4-11(13)22/h3,6-9,11,13,18H,1-2,4-5,22H2,(H2,23,30)(H2,24,25,26,28)/t11-,13+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.220	n/a	n/a	n/a	n/a	7.5	25
TAIHO PHARMACEUTICAL CO., LTD. US Patent					Assay Description The in vitro inhibitory activity of the compound of the present invention against Syk kinase activity was assayed under the following conditions: the...				US Patent US9145414 (2015) BindingDB Entry DOI: 10.7270/Q2513X18
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM182781 (US9145414, 65) Show SMILES Cn1cc2cc(Nc3nc(N[C@@H]4CCCC[C@@H]4N)nnc3C(N)=O)cc(-c3ccccc3)c2n1 |r| Show InChI InChI=1S/C24H27N9O/c1-33-13-15-11-16(12-17(20(15)32-33)14-7-3-2-4-8-14)27-23-21(22(26)34)30-31-24(29-23)28-19-10-6-5-9-18(19)25/h2-4,7-8,11-13,18-19H,5-6,9-10,25H2,1H3,(H2,26,34)(H2,27,28,29,31)/t18-,19+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.230	n/a	n/a	n/a	n/a	7.5	25
TAIHO PHARMACEUTICAL CO., LTD. US Patent					Assay Description The in vitro inhibitory activity of the compound of the present invention against Syk kinase activity was assayed under the following conditions: the...				US Patent US9145414 (2015) BindingDB Entry DOI: 10.7270/Q2513X18
					More data for this Ligand-Target Pair
Endothelin receptor type B (Bos taurus)	BDBM50289647 (CHEMBL263855 | Compound RES-701-1(1-10)/[A15]ET-1) Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H]1CC(=O)NCC(=O)N[C@H](CC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2cnc[nH]2)C(=O)NCC(=O)N[C@H]([C@@H](C)O)C(=O)N[C@@H](C)C(=O)N2CCC[C@@H]2C(=O)N1)C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(O)=O Show InChI InChI=1S/C117H150N28O27/c1-12-60(7)97(113(167)140-89(117(171)172)43-69-51-123-78-31-22-19-28-75(69)78)144-114(168)98(61(8)13-2)143-110(164)88(48-95(152)153)137-103(157)79(38-58(3)4)132-106(160)85(45-71-53-120-57-127-71)131-100(154)62(9)128-102(156)80(39-65-24-15-14-16-25-65)133-104(158)81(40-66-33-35-72(147)36-34-66)139-112(166)96(59(5)6)142-109(163)83(42-68-50-122-77-30-21-18-27-74(68)77)135-108(162)87-47-92(149)124-54-93(150)130-86(46-91(118)148)107(161)134-82(41-67-49-121-76-29-20-17-26-73(67)76)105(159)136-84(44-70-52-119-56-126-70)101(155)125-55-94(151)141-99(64(11)146)115(169)129-63(10)116(170)145-37-23-32-90(145)111(165)138-87/h14-22,24-31,33-36,49-53,56-64,79-90,96-99,121-123,146-147H,12-13,23,32,37-48,54-55H2,1-11H3,(H2,118,148)(H,119,126)(H,120,127)(H,124,149)(H,125,155)(H,128,156)(H,129,169)(H,130,150)(H,131,154)(H,132,160)(H,133,158)(H,134,161)(H,135,162)(H,136,159)(H,137,157)(H,138,165)(H,139,166)(H,140,167)(H,141,151)(H,142,163)(H,143,164)(H,144,168)(H,152,153)(H,171,172)/t60-,61-,62-,63-,64+,79-,80-,81-,82-,83-,84+,85-,86+,87+,88-,89-,90+,96-,97-,98-,99+/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article	n/a	n/a	0.240	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Binding activity to ET-B receptor on bovine cerebellum membrane				Bioorg Med Chem Lett 7: 1715-1720 (1997) Article DOI: 10.1016/S0960-894X(97)00296-5 BindingDB Entry DOI: 10.7270/Q27081F2
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM182783 (US9145414, 67) Show SMILES Cn1cc(cn1)-n1ccc2c(Nc3nc(N[C@@H]4CCCC[C@@H]4N)nnc3C(N)=O)cccc12 |r| Show InChI InChI=1S/C22H26N10O/c1-31-12-13(11-25-31)32-10-9-14-16(7-4-8-18(14)32)26-21-19(20(24)33)29-30-22(28-21)27-17-6-3-2-5-15(17)23/h4,7-12,15,17H,2-3,5-6,23H2,1H3,(H2,24,33)(H2,26,27,28,30)/t15-,17+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.260	n/a	n/a	n/a	n/a	7.5	25
TAIHO PHARMACEUTICAL CO., LTD. US Patent					Assay Description The in vitro inhibitory activity of the compound of the present invention against Syk kinase activity was assayed under the following conditions: the...				US Patent US9145414 (2015) BindingDB Entry DOI: 10.7270/Q2513X18
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM182806 (US9145414, 220) Show SMILES N[C@H]1CCCC[C@H]1Nc1nnc(C(N)=O)c(Nc2ccc3sccc3c2)n1 |r| Show InChI InChI=1S/C18H21N7OS/c19-12-3-1-2-4-13(12)22-18-23-17(15(16(20)26)24-25-18)21-11-5-6-14-10(9-11)7-8-27-14/h5-9,12-13H,1-4,19H2,(H2,20,26)(H2,21,22,23,25)/t12-,13+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.260	n/a	n/a	n/a	n/a	7.5	25
TAIHO PHARMACEUTICAL CO., LTD. US Patent					Assay Description The in vitro inhibitory activity of the compound of the present invention against Syk kinase activity was assayed under the following conditions: the...				US Patent US9145414 (2015) BindingDB Entry DOI: 10.7270/Q2513X18
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM182789 (US9145414, 91) Show SMILES Cc1cc(Nc2nc(N[C@@H]3CCCC[C@@H]3N)nnc2C(N)=O)cc2nn(C)cc12 |r| Show InChI InChI=1S/C19H25N9O/c1-10-7-11(8-15-12(10)9-28(2)27-15)22-18-16(17(21)29)25-26-19(24-18)23-14-6-4-3-5-13(14)20/h7-9,13-14H,3-6,20H2,1-2H3,(H2,21,29)(H2,22,23,24,26)/t13-,14+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.260	n/a	n/a	n/a	n/a	7.5	25
TAIHO PHARMACEUTICAL CO., LTD. US Patent					Assay Description The in vitro inhibitory activity of the compound of the present invention against Syk kinase activity was assayed under the following conditions: the...				US Patent US9145414 (2015) BindingDB Entry DOI: 10.7270/Q2513X18
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM182774 (US9145414, 48) Show SMILES COc1ccc2sc(Nc3nc(N[C@@H]4CCCC[C@@H]4N)nnc3C(N)=O)c(C)c2c1 |r| Show InChI InChI=1S/C20H25N7O2S/c1-10-12-9-11(29-2)7-8-15(12)30-19(10)24-18-16(17(22)28)26-27-20(25-18)23-14-6-4-3-5-13(14)21/h7-9,13-14H,3-6,21H2,1-2H3,(H2,22,28)(H2,23,24,25,27)/t13-,14+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.270	n/a	n/a	n/a	n/a	7.5	25
TAIHO PHARMACEUTICAL CO., LTD. US Patent					Assay Description The in vitro inhibitory activity of the compound of the present invention against Syk kinase activity was assayed under the following conditions: the...				US Patent US9145414 (2015) BindingDB Entry DOI: 10.7270/Q2513X18
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM182798 (US9145414, 161) Show SMILES N[C@H]1CCCC[C@H]1Nc1nnc(C(N)=O)c(Nc2cc3ccccc3s2)n1 |r| Show InChI InChI=1S/C18H21N7OS/c19-11-6-2-3-7-12(11)21-18-23-17(15(16(20)26)24-25-18)22-14-9-10-5-1-4-8-13(10)27-14/h1,4-5,8-9,11-12H,2-3,6-7,19H2,(H2,20,26)(H2,21,22,23,25)/t11-,12+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.280	n/a	n/a	n/a	n/a	7.5	25
TAIHO PHARMACEUTICAL CO., LTD. US Patent					Assay Description The in vitro inhibitory activity of the compound of the present invention against Syk kinase activity was assayed under the following conditions: the...				US Patent US9145414 (2015) BindingDB Entry DOI: 10.7270/Q2513X18
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM182805 (US9145414, 212) Show SMILES N[C@H]1CCCC[C@H]1Nc1nnc(C(N)=O)c(Nc2csc3ccccc23)n1 |r| Show InChI InChI=1S/C18H21N7OS/c19-11-6-2-3-7-12(11)22-18-23-17(15(16(20)26)24-25-18)21-13-9-27-14-8-4-1-5-10(13)14/h1,4-5,8-9,11-12H,2-3,6-7,19H2,(H2,20,26)(H2,21,22,23,25)/t11-,12+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.290	n/a	n/a	n/a	n/a	7.5	25
TAIHO PHARMACEUTICAL CO., LTD. US Patent					Assay Description The in vitro inhibitory activity of the compound of the present invention against Syk kinase activity was assayed under the following conditions: the...				US Patent US9145414 (2015) BindingDB Entry DOI: 10.7270/Q2513X18
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM182810 (US9145414, 258) Show SMILES COC[C@H](N)[C@@H](C)Nc1nnc(C(N)=O)c(Nc2cc(-c3ccccc3)c3nn(C)cc3c2)n1 |r| Show InChI InChI=1S/C23H27N9O2/c1-13(18(24)12-34-3)26-23-28-22(20(21(25)33)29-30-23)27-16-9-15-11-32(2)31-19(15)17(10-16)14-7-5-4-6-8-14/h4-11,13,18H,12,24H2,1-3H3,(H2,25,33)(H2,26,27,28,30)/t13-,18+/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.290	n/a	n/a	n/a	n/a	7.5	25
TAIHO PHARMACEUTICAL CO., LTD. US Patent					Assay Description The in vitro inhibitory activity of the compound of the present invention against Syk kinase activity was assayed under the following conditions: the...				US Patent US9145414 (2015) BindingDB Entry DOI: 10.7270/Q2513X18
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM182799 (US9145414, 164) Show SMILES N[C@H]1CCCC[C@H]1Nc1nnc(C(N)=O)c(Nc2cc(cs2)-c2ccccc2)n1 |r| Show InChI InChI=1S/C20H23N7OS/c21-14-8-4-5-9-15(14)23-20-25-19(17(18(22)28)26-27-20)24-16-10-13(11-29-16)12-6-2-1-3-7-12/h1-3,6-7,10-11,14-15H,4-5,8-9,21H2,(H2,22,28)(H2,23,24,25,27)/t14-,15+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.290	n/a	n/a	n/a	n/a	7.5	25
TAIHO PHARMACEUTICAL CO., LTD. US Patent					Assay Description The in vitro inhibitory activity of the compound of the present invention against Syk kinase activity was assayed under the following conditions: the...				US Patent US9145414 (2015) BindingDB Entry DOI: 10.7270/Q2513X18
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM182820 (US9145414, 316) Show SMILES CCn1cc2ccc(Nc3nc(N[C@@H]4CCCCC[C@@H]4N)nnc3C(N)=O)cc2n1 |r| Show InChI InChI=1S/C20H27N9O/c1-2-29-11-12-8-9-13(10-16(12)28-29)23-19-17(18(22)30)26-27-20(25-19)24-15-7-5-3-4-6-14(15)21/h8-11,14-15H,2-7,21H2,1H3,(H2,22,30)(H2,23,24,25,27)/t14-,15+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.310	n/a	n/a	n/a	n/a	7.5	25
TAIHO PHARMACEUTICAL CO., LTD. US Patent					Assay Description The in vitro inhibitory activity of the compound of the present invention against Syk kinase activity was assayed under the following conditions: the...				US Patent US9145414 (2015) BindingDB Entry DOI: 10.7270/Q2513X18
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM182804 (US9145414, 209) Show SMILES N[C@H]1CCCC[C@H]1Nc1nnc(C(N)=O)c(Nc2cccc3nn(cc23)C(F)F)n1 |r| Show InChI InChI=1S/C18H21F2N9O/c19-17(20)29-8-9-11(6-3-7-12(9)28-29)23-16-14(15(22)30)26-27-18(25-16)24-13-5-2-1-4-10(13)21/h3,6-8,10,13,17H,1-2,4-5,21H2,(H2,22,30)(H2,23,24,25,27)/t10-,13+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.330	n/a	n/a	n/a	n/a	7.5	25
TAIHO PHARMACEUTICAL CO., LTD. US Patent					Assay Description The in vitro inhibitory activity of the compound of the present invention against Syk kinase activity was assayed under the following conditions: the...				US Patent US9145414 (2015) BindingDB Entry DOI: 10.7270/Q2513X18
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM182811 (US9145414, 259) Show SMILES Cc1cc(Nc2nc(N[C@@H]3CCCC[C@@H]3N)nnc2C(N)=O)cc2cccnc12 |r| Show InChI InChI=1S/C20H24N8O/c1-11-9-13(10-12-5-4-8-23-16(11)12)24-19-17(18(22)29)27-28-20(26-19)25-15-7-3-2-6-14(15)21/h4-5,8-10,14-15H,2-3,6-7,21H2,1H3,(H2,22,29)(H2,24,25,26,28)/t14-,15+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.330	n/a	n/a	n/a	n/a	7.5	25
TAIHO PHARMACEUTICAL CO., LTD. US Patent					Assay Description The in vitro inhibitory activity of the compound of the present invention against Syk kinase activity was assayed under the following conditions: the...				US Patent US9145414 (2015) BindingDB Entry DOI: 10.7270/Q2513X18
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM182778 (US9145414, 60) Show SMILES Cc1cc(Nc2nc(N[C@@H]3CCCC[C@@H]3N)nnc2C(N)=O)c2ccn(C)c2c1 |r| Show InChI InChI=1S/C20H26N8O/c1-11-9-15(12-7-8-28(2)16(12)10-11)23-19-17(18(22)29)26-27-20(25-19)24-14-6-4-3-5-13(14)21/h7-10,13-14H,3-6,21H2,1-2H3,(H2,22,29)(H2,23,24,25,27)/t13-,14+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.330	n/a	n/a	n/a	n/a	7.5	25
TAIHO PHARMACEUTICAL CO., LTD. US Patent					Assay Description The in vitro inhibitory activity of the compound of the present invention against Syk kinase activity was assayed under the following conditions: the...				US Patent US9145414 (2015) BindingDB Entry DOI: 10.7270/Q2513X18
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM182817 (US9145414, 284) Show SMILES COC[C@H](N)[C@@H](C)Nc1nnc(C(N)=O)c(Nc2cc(C)c3n(ncc3c2)C(C)C)n1 |r| Show InChI InChI=1S/C20H29N9O2/c1-10(2)29-17-11(3)6-14(7-13(17)8-23-29)25-19-16(18(22)30)27-28-20(26-19)24-12(4)15(21)9-31-5/h6-8,10,12,15H,9,21H2,1-5H3,(H2,22,30)(H2,24,25,26,28)/t12-,15+/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.340	n/a	n/a	n/a	n/a	7.5	25
TAIHO PHARMACEUTICAL CO., LTD. US Patent					Assay Description The in vitro inhibitory activity of the compound of the present invention against Syk kinase activity was assayed under the following conditions: the...				US Patent US9145414 (2015) BindingDB Entry DOI: 10.7270/Q2513X18
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM182808 (US9145414, 256) Show SMILES COC[C@H](N)[C@@H](C)Nc1nnc(C(N)=O)c(Nc2cc(C)cc3n(C)ccc23)n1 |r| Show InChI InChI=1S/C19H26N8O2/c1-10-7-14(12-5-6-27(3)15(12)8-10)23-18-16(17(21)28)25-26-19(24-18)22-11(2)13(20)9-29-4/h5-8,11,13H,9,20H2,1-4H3,(H2,21,28)(H2,22,23,24,26)/t11-,13+/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.350	n/a	n/a	n/a	n/a	7.5	25
TAIHO PHARMACEUTICAL CO., LTD. US Patent					Assay Description The in vitro inhibitory activity of the compound of the present invention against Syk kinase activity was assayed under the following conditions: the...				US Patent US9145414 (2015) BindingDB Entry DOI: 10.7270/Q2513X18
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM182807 (US9145414, 245) Show SMILES CC[C@H](N)CNc1nnc(C(N)=O)c(Nc2cccc3sccc23)n1 |r| Show InChI InChI=1S/C16H19N7OS/c1-2-9(17)8-19-16-21-15(13(14(18)24)22-23-16)20-11-4-3-5-12-10(11)6-7-25-12/h3-7,9H,2,8,17H2,1H3,(H2,18,24)(H2,19,20,21,23)/t9-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.350	n/a	n/a	n/a	n/a	7.5	25
TAIHO PHARMACEUTICAL CO., LTD. US Patent					Assay Description The in vitro inhibitory activity of the compound of the present invention against Syk kinase activity was assayed under the following conditions: the...				US Patent US9145414 (2015) BindingDB Entry DOI: 10.7270/Q2513X18
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM182769 (US9145414, 25) Show SMILES Cn1ccc(n1)-n1ccc2c(Nc3nc(N[C@@H]4CCCC[C@@H]4N)nnc3C(N)=O)cccc12 |r| Show InChI InChI=1S/C22H26N10O/c1-31-11-10-18(30-31)32-12-9-13-15(7-4-8-17(13)32)25-21-19(20(24)33)28-29-22(27-21)26-16-6-3-2-5-14(16)23/h4,7-12,14,16H,2-3,5-6,23H2,1H3,(H2,24,33)(H2,25,26,27,29)/t14-,16+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.360	n/a	n/a	n/a	n/a	7.5	25
TAIHO PHARMACEUTICAL CO., LTD. US Patent					Assay Description The in vitro inhibitory activity of the compound of the present invention against Syk kinase activity was assayed under the following conditions: the...				US Patent US9145414 (2015) BindingDB Entry DOI: 10.7270/Q2513X18
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM182800 (US9145414, 165) Show SMILES N[C@H]1CCCC[C@H]1Nc1nnc(C(N)=O)c(Nc2ccc3cnn(C(F)F)c3c2)n1 |r| Show InChI InChI=1S/C18H21F2N9O/c19-17(20)29-13-7-10(6-5-9(13)8-23-29)24-16-14(15(22)30)27-28-18(26-16)25-12-4-2-1-3-11(12)21/h5-8,11-12,17H,1-4,21H2,(H2,22,30)(H2,24,25,26,28)/t11-,12+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.360	n/a	n/a	n/a	n/a	7.5	25
TAIHO PHARMACEUTICAL CO., LTD. US Patent					Assay Description The in vitro inhibitory activity of the compound of the present invention against Syk kinase activity was assayed under the following conditions: the...				US Patent US9145414 (2015) BindingDB Entry DOI: 10.7270/Q2513X18
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM182763 (US9145414, 3) Show SMILES Cn1ccc2c(Nc3nc(N[C@@H]4CCCC[C@@H]4N)nnc3C(N)=O)cccc12 |r| Show InChI InChI=1S/C19H24N8O/c1-27-10-9-11-13(7-4-8-15(11)27)22-18-16(17(21)28)25-26-19(24-18)23-14-6-3-2-5-12(14)20/h4,7-10,12,14H,2-3,5-6,20H2,1H3,(H2,21,28)(H2,22,23,24,26)/t12-,14+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.360	n/a	n/a	n/a	n/a	7.5	25
TAIHO PHARMACEUTICAL CO., LTD. US Patent					Assay Description The in vitro inhibitory activity of the compound of the present invention against Syk kinase activity was assayed under the following conditions: the...				US Patent US9145414 (2015) BindingDB Entry DOI: 10.7270/Q2513X18
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM182784 (US9145414, 73) Show SMILES N[C@H]1CCCC[C@H]1Nc1nnc(C(N)=O)c(Nc2cccc3n(ccc23)C2CC[C@H](O)CC2)n1 |r,wD:6.7,1.0,29.32,(5.88,1.29,;5.88,2.83,;7.21,3.6,;7.21,5.14,;5.88,5.91,;4.54,5.14,;4.54,3.6,;3.21,2.83,;1.87,3.6,;1.87,5.14,;.54,5.91,;-.79,5.14,;-2.13,5.91,;-3.46,5.14,;-2.13,7.45,;-.79,3.6,;-2.13,2.83,;-2.13,1.29,;-.79,.52,;-.79,-1.02,;-2.13,-1.79,;-3.46,-1.02,;-4.92,-1.5,;-5.83,-.25,;-4.92,.99,;-3.46,.52,;-5.32,-2.99,;-4.23,-4.07,;-4.63,-5.56,;-6.12,-5.96,;-6.52,-7.45,;-7.21,-4.87,;-6.81,-3.38,;.54,2.83,)| Show InChI InChI=1S/C24H32N8O2/c25-17-4-1-2-5-19(17)28-24-29-23(21(22(26)34)30-31-24)27-18-6-3-7-20-16(18)12-13-32(20)14-8-10-15(33)11-9-14/h3,6-7,12-15,17,19,33H,1-2,4-5,8-11,25H2,(H2,26,34)(H2,27,28,29,31)/t14?,15-,17-,19+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.370	n/a	n/a	n/a	n/a	7.5	25
TAIHO PHARMACEUTICAL CO., LTD. US Patent					Assay Description The in vitro inhibitory activity of the compound of the present invention against Syk kinase activity was assayed under the following conditions: the...				US Patent US9145414 (2015) BindingDB Entry DOI: 10.7270/Q2513X18
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM182822 (US9145414, 359) Show SMILES Cc1cc(Nc2nc(N[C@@H]3CCOC[C@@H]3N)nnc2C(N)=O)cc2ccsc12 |r| Show InChI InChI=1S/C18H21N7O2S/c1-9-6-11(7-10-3-5-28-15(9)10)21-17-14(16(20)26)24-25-18(23-17)22-13-2-4-27-8-12(13)19/h3,5-7,12-13H,2,4,8,19H2,1H3,(H2,20,26)(H2,21,22,23,25)/t12-,13+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.370	n/a	n/a	n/a	n/a	7.5	25
TAIHO PHARMACEUTICAL CO., LTD. US Patent					Assay Description The in vitro inhibitory activity of the compound of the present invention against Syk kinase activity was assayed under the following conditions: the...				US Patent US9145414 (2015) BindingDB Entry DOI: 10.7270/Q2513X18
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM182780 (US9145414, 62) Show SMILES Cc1cc(Nc2nc(N[C@@H]3CCCC[C@@H]3N)nnc2C(N)=O)cc2cn(nc12)C(F)F |r| Show InChI InChI=1S/C19H23F2N9O/c1-9-6-11(7-10-8-30(18(20)21)29-14(9)10)24-17-15(16(23)31)27-28-19(26-17)25-13-5-3-2-4-12(13)22/h6-8,12-13,18H,2-5,22H2,1H3,(H2,23,31)(H2,24,25,26,28)/t12-,13+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.370	n/a	n/a	n/a	n/a	7.5	25
TAIHO PHARMACEUTICAL CO., LTD. US Patent					Assay Description The in vitro inhibitory activity of the compound of the present invention against Syk kinase activity was assayed under the following conditions: the...				US Patent US9145414 (2015) BindingDB Entry DOI: 10.7270/Q2513X18
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM182779 (US9145414, 61) Show SMILES Cc1cc(Nc2nc(N[C@@H]3CCOC[C@@H]3N)nnc2C(N)=O)cc2cn(nc12)C(C)(C)C |r| Show InChI InChI=1S/C21H29N9O2/c1-11-7-13(8-12-9-30(21(2,3)4)29-16(11)12)24-19-17(18(23)31)27-28-20(26-19)25-15-5-6-32-10-14(15)22/h7-9,14-15H,5-6,10,22H2,1-4H3,(H2,23,31)(H2,24,25,26,28)/t14-,15+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.370	n/a	n/a	n/a	n/a	7.5	25
TAIHO PHARMACEUTICAL CO., LTD. US Patent					Assay Description The in vitro inhibitory activity of the compound of the present invention against Syk kinase activity was assayed under the following conditions: the...				US Patent US9145414 (2015) BindingDB Entry DOI: 10.7270/Q2513X18
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM182788 (US9145414, 79) Show SMILES CCn1cc2cc(Nc3nc(N[C@@H]4CCCC[C@@H]4N)nnc3C(N)=O)cc(-n3cccn3)c2n1 |r| Show InChI InChI=1S/C22H27N11O/c1-2-32-12-13-10-14(11-17(18(13)31-32)33-9-5-8-25-33)26-21-19(20(24)34)29-30-22(28-21)27-16-7-4-3-6-15(16)23/h5,8-12,15-16H,2-4,6-7,23H2,1H3,(H2,24,34)(H2,26,27,28,30)/t15-,16+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.370	n/a	n/a	n/a	n/a	7.5	25
TAIHO PHARMACEUTICAL CO., LTD. US Patent					Assay Description The in vitro inhibitory activity of the compound of the present invention against Syk kinase activity was assayed under the following conditions: the...				US Patent US9145414 (2015) BindingDB Entry DOI: 10.7270/Q2513X18
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM182797 (US9145414, 160) Show SMILES N[C@H]1COCC[C@H]1Nc1nnc(C(N)=O)c(Nc2cccc3n(ccc23)C2CC2)n1 |r| Show InChI InChI=1S/C20H24N8O2/c21-13-10-30-9-7-15(13)24-20-25-19(17(18(22)29)26-27-20)23-14-2-1-3-16-12(14)6-8-28(16)11-4-5-11/h1-3,6,8,11,13,15H,4-5,7,9-10,21H2,(H2,22,29)(H2,23,24,25,27)/t13-,15+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.380	n/a	n/a	n/a	n/a	7.5	25
TAIHO PHARMACEUTICAL CO., LTD. US Patent					Assay Description The in vitro inhibitory activity of the compound of the present invention against Syk kinase activity was assayed under the following conditions: the...				US Patent US9145414 (2015) BindingDB Entry DOI: 10.7270/Q2513X18
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM182802 (US9145414, 184) Show SMILES N[C@H]1CCCC[C@H]1Nc1nnc(C(N)=O)c(Nc2nc(cs2)-c2ccccc2)n1 |r| Show InChI InChI=1S/C19H22N8OS/c20-12-8-4-5-9-13(12)22-18-24-17(15(16(21)28)26-27-18)25-19-23-14(10-29-19)11-6-2-1-3-7-11/h1-3,6-7,10,12-13H,4-5,8-9,20H2,(H2,21,28)(H2,22,23,24,25,27)/t12-,13+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.380	n/a	n/a	n/a	n/a	7.5	25
TAIHO PHARMACEUTICAL CO., LTD. US Patent					Assay Description The in vitro inhibitory activity of the compound of the present invention against Syk kinase activity was assayed under the following conditions: the...				US Patent US9145414 (2015) BindingDB Entry DOI: 10.7270/Q2513X18
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM182809 (US9145414, 257) Show SMILES Cn1cc2cc(Nc3nc(N[C@@H]4CCOC[C@@H]4N)nnc3C(N)=O)cc(-c3ccccc3)c2n1 |r| Show InChI InChI=1S/C23H25N9O2/c1-32-11-14-9-15(10-16(19(14)31-32)13-5-3-2-4-6-13)26-22-20(21(25)33)29-30-23(28-22)27-18-7-8-34-12-17(18)24/h2-6,9-11,17-18H,7-8,12,24H2,1H3,(H2,25,33)(H2,26,27,28,30)/t17-,18+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.380	n/a	n/a	n/a	n/a	7.5	25
TAIHO PHARMACEUTICAL CO., LTD. US Patent					Assay Description The in vitro inhibitory activity of the compound of the present invention against Syk kinase activity was assayed under the following conditions: the...				US Patent US9145414 (2015) BindingDB Entry DOI: 10.7270/Q2513X18
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM182791 (US9145414, 97) Show SMILES CCn1ncc2c(C)cc(Nc3nc(N[C@@H]4CCCC[C@@H]4N)nnc3C(N)=O)cc12 |r| Show InChI InChI=1S/C20H27N9O/c1-3-29-16-9-12(8-11(2)13(16)10-23-29)24-19-17(18(22)30)27-28-20(26-19)25-15-7-5-4-6-14(15)21/h8-10,14-15H,3-7,21H2,1-2H3,(H2,22,30)(H2,24,25,26,28)/t14-,15+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.390	n/a	n/a	n/a	n/a	7.5	25
TAIHO PHARMACEUTICAL CO., LTD. US Patent					Assay Description The in vitro inhibitory activity of the compound of the present invention against Syk kinase activity was assayed under the following conditions: the...				US Patent US9145414 (2015) BindingDB Entry DOI: 10.7270/Q2513X18
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM182803 (US9145414, 208) Show SMILES N[C@H]1CCCC[C@H]1Nc1nnc(C(N)=O)c(Nc2cc(cc3sccc23)C#N)n1 |r| Show InChI InChI=1S/C19H20N8OS/c20-9-10-7-14(11-5-6-29-15(11)8-10)23-18-16(17(22)28)26-27-19(25-18)24-13-4-2-1-3-12(13)21/h5-8,12-13H,1-4,21H2,(H2,22,28)(H2,23,24,25,27)/t12-,13+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.400	n/a	n/a	n/a	n/a	7.5	25
TAIHO PHARMACEUTICAL CO., LTD. US Patent					Assay Description The in vitro inhibitory activity of the compound of the present invention against Syk kinase activity was assayed under the following conditions: the...				US Patent US9145414 (2015) BindingDB Entry DOI: 10.7270/Q2513X18
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM182761 (US9145414, 1) Show SMILES N[C@H]1CCCC[C@H]1Nc1nnc(C(N)=O)c(Nc2ccc3ncccc3c2)n1 |r| Show InChI InChI=1S/C19H22N8O/c20-13-5-1-2-6-15(13)24-19-25-18(16(17(21)28)26-27-19)23-12-7-8-14-11(10-12)4-3-9-22-14/h3-4,7-10,13,15H,1-2,5-6,20H2,(H2,21,28)(H2,23,24,25,27)/t13-,15+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.400	n/a	n/a	n/a	n/a	7.5	25
TAIHO PHARMACEUTICAL CO., LTD. US Patent					Assay Description The in vitro inhibitory activity of the compound of the present invention against Syk kinase activity was assayed under the following conditions: the...				US Patent US9145414 (2015) BindingDB Entry DOI: 10.7270/Q2513X18
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM182813 (US9145414, 267) Show SMILES Cc1cc(Nc2nc(N[C@@H]3CCOC[C@@H]3N)nnc2C(N)=O)c2ccn(C)c2c1 |r| Show InChI InChI=1S/C19H24N8O2/c1-10-7-14(11-3-5-27(2)15(11)8-10)22-18-16(17(21)28)25-26-19(24-18)23-13-4-6-29-9-12(13)20/h3,5,7-8,12-13H,4,6,9,20H2,1-2H3,(H2,21,28)(H2,22,23,24,26)/t12-,13+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.410	n/a	n/a	n/a	n/a	7.5	25
TAIHO PHARMACEUTICAL CO., LTD. US Patent					Assay Description The in vitro inhibitory activity of the compound of the present invention against Syk kinase activity was assayed under the following conditions: the...				US Patent US9145414 (2015) BindingDB Entry DOI: 10.7270/Q2513X18
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM182815 (US9145414, 277) Show SMILES N[C@H]1COCC[C@H]1Nc1nnc(C(N)=O)c(Nc2cccc3n(ccc23)C2CCC2)n1 |r| Show InChI InChI=1S/C21H26N8O2/c22-14-11-31-10-8-16(14)25-21-26-20(18(19(23)30)27-28-21)24-15-5-2-6-17-13(15)7-9-29(17)12-3-1-4-12/h2,5-7,9,12,14,16H,1,3-4,8,10-11,22H2,(H2,23,30)(H2,24,25,26,28)/t14-,16+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.410	n/a	n/a	n/a	n/a	7.5	25
TAIHO PHARMACEUTICAL CO., LTD. US Patent					Assay Description The in vitro inhibitory activity of the compound of the present invention against Syk kinase activity was assayed under the following conditions: the...				US Patent US9145414 (2015) BindingDB Entry DOI: 10.7270/Q2513X18
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM182793 (US9145414, 100) Show SMILES CC(C)(C)n1cc2cc(Nc3nc(N[C@@H]4CCOC[C@@H]4N)nnc3C(N)=O)cc(Cl)c2n1 |r| Show InChI InChI=1S/C20H26ClN9O2/c1-20(2,3)30-8-10-6-11(7-12(21)15(10)29-30)24-18-16(17(23)31)27-28-19(26-18)25-14-4-5-32-9-13(14)22/h6-8,13-14H,4-5,9,22H2,1-3H3,(H2,23,31)(H2,24,25,26,28)/t13-,14+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.410	n/a	n/a	n/a	n/a	7.5	25
TAIHO PHARMACEUTICAL CO., LTD. US Patent					Assay Description The in vitro inhibitory activity of the compound of the present invention against Syk kinase activity was assayed under the following conditions: the...				US Patent US9145414 (2015) BindingDB Entry DOI: 10.7270/Q2513X18
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM182786 (US9145414, 77) Show SMILES N[C@H]1CCCC[C@H]1Nc1nnc(C(N)=O)c(Nc2cc(cs2)-c2ccccn2)n1 |r| Show InChI InChI=1S/C19H22N8OS/c20-12-5-1-2-7-14(12)23-19-25-18(16(17(21)28)26-27-19)24-15-9-11(10-29-15)13-6-3-4-8-22-13/h3-4,6,8-10,12,14H,1-2,5,7,20H2,(H2,21,28)(H2,23,24,25,27)/t12-,14+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.420	n/a	n/a	n/a	n/a	7.5	25
TAIHO PHARMACEUTICAL CO., LTD. US Patent					Assay Description The in vitro inhibitory activity of the compound of the present invention against Syk kinase activity was assayed under the following conditions: the...				US Patent US9145414 (2015) BindingDB Entry DOI: 10.7270/Q2513X18
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM182772 (US9145414, 34) Show SMILES N[C@H]1CCCC[C@H]1Nc1nnc(C(N)=O)c(Nc2cccc3n(ccc23)C2COC2)n1 |r| Show InChI InChI=1S/C21H26N8O2/c22-14-4-1-2-5-16(14)25-21-26-20(18(19(23)30)27-28-21)24-15-6-3-7-17-13(15)8-9-29(17)12-10-31-11-12/h3,6-9,12,14,16H,1-2,4-5,10-11,22H2,(H2,23,30)(H2,24,25,26,28)/t14-,16+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.420	n/a	n/a	n/a	n/a	7.5	25
TAIHO PHARMACEUTICAL CO., LTD. US Patent					Assay Description The in vitro inhibitory activity of the compound of the present invention against Syk kinase activity was assayed under the following conditions: the...				US Patent US9145414 (2015) BindingDB Entry DOI: 10.7270/Q2513X18
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM182775 (US9145414, 50) Show SMILES CCn1nc(C)c2ccc(Nc3nc(N[C@@H]4CCCC[C@@H]4N)nnc3C(N)=O)cc12 |r| Show InChI InChI=1S/C20H27N9O/c1-3-29-16-10-12(8-9-13(16)11(2)28-29)23-19-17(18(22)30)26-27-20(25-19)24-15-7-5-4-6-14(15)21/h8-10,14-15H,3-7,21H2,1-2H3,(H2,22,30)(H2,23,24,25,27)/t14-,15+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.420	n/a	n/a	n/a	n/a	7.5	25
TAIHO PHARMACEUTICAL CO., LTD. US Patent					Assay Description The in vitro inhibitory activity of the compound of the present invention against Syk kinase activity was assayed under the following conditions: the...				US Patent US9145414 (2015) BindingDB Entry DOI: 10.7270/Q2513X18
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM182796 (US9145414, 154) Show SMILES CCn1ncc2ccc(Nc3nc(N[C@@H]4CCCC[C@@H]4N)nnc3C(N)=O)cc12 |r| Show InChI InChI=1S/C19H25N9O/c1-2-28-15-9-12(8-7-11(15)10-22-28)23-18-16(17(21)29)26-27-19(25-18)24-14-6-4-3-5-13(14)20/h7-10,13-14H,2-6,20H2,1H3,(H2,21,29)(H2,23,24,25,27)/t13-,14+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.430	n/a	n/a	n/a	n/a	7.5	25
TAIHO PHARMACEUTICAL CO., LTD. US Patent					Assay Description The in vitro inhibitory activity of the compound of the present invention against Syk kinase activity was assayed under the following conditions: the...				US Patent US9145414 (2015) BindingDB Entry DOI: 10.7270/Q2513X18
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM182762 (US9145414, 2) Show SMILES N[C@H]1CCCC[C@H]1Nc1nnc(C(N)=O)c(Nc2cccc3sccc23)n1 |r| Show InChI InChI=1S/C18H21N7OS/c19-11-4-1-2-5-13(11)22-18-23-17(15(16(20)26)24-25-18)21-12-6-3-7-14-10(12)8-9-27-14/h3,6-9,11,13H,1-2,4-5,19H2,(H2,20,26)(H2,21,22,23,25)/t11-,13+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.460	n/a	n/a	n/a	n/a	7.5	25
TAIHO PHARMACEUTICAL CO., LTD. US Patent					Assay Description The in vitro inhibitory activity of the compound of the present invention against Syk kinase activity was assayed under the following conditions: the...				US Patent US9145414 (2015) BindingDB Entry DOI: 10.7270/Q2513X18
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM182764 (US9145414, 11) Show SMILES N[C@H]1CCCC[C@H]1Nc1nnc(C(N)=O)c(Nc2ccc3nn(cc3c2)C2CCC2)n1 |r| Show InChI InChI=1S/C21H27N9O/c22-15-6-1-2-7-17(15)25-21-26-20(18(19(23)31)27-28-21)24-13-8-9-16-12(10-13)11-30(29-16)14-4-3-5-14/h8-11,14-15,17H,1-7,22H2,(H2,23,31)(H2,24,25,26,28)/t15-,17+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.470	n/a	n/a	n/a	n/a	7.5	25
TAIHO PHARMACEUTICAL CO., LTD. US Patent					Assay Description The in vitro inhibitory activity of the compound of the present invention against Syk kinase activity was assayed under the following conditions: the...				US Patent US9145414 (2015) BindingDB Entry DOI: 10.7270/Q2513X18
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM182816 (US9145414, 282) Show SMILES CCOC[C@H](N)[C@@H](C)Nc1nnc(C(N)=O)c(Nc2cc(C)c3ncccc3c2)n1 |r| Show InChI InChI=1S/C20H26N8O2/c1-4-30-10-15(21)12(3)24-20-26-19(17(18(22)29)27-28-20)25-14-8-11(2)16-13(9-14)6-5-7-23-16/h5-9,12,15H,4,10,21H2,1-3H3,(H2,22,29)(H2,24,25,26,28)/t12-,15+/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.480	n/a	n/a	n/a	n/a	7.5	25
TAIHO PHARMACEUTICAL CO., LTD. US Patent					Assay Description The in vitro inhibitory activity of the compound of the present invention against Syk kinase activity was assayed under the following conditions: the...				US Patent US9145414 (2015) BindingDB Entry DOI: 10.7270/Q2513X18
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM182765 (US9145414, 13) Show SMILES Cn1cc(cn1)-c1cc(Nc2nc(N[C@@H]3CCCC[C@@H]3N)nnc2C(N)=O)c2cnn(C)c2c1 |r| Show InChI InChI=1S/C22H27N11O/c1-32-11-13(9-25-32)12-7-17(14-10-26-33(2)18(14)8-12)27-21-19(20(24)34)30-31-22(29-21)28-16-6-4-3-5-15(16)23/h7-11,15-16H,3-6,23H2,1-2H3,(H2,24,34)(H2,27,28,29,31)/t15-,16+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.490	n/a	n/a	n/a	n/a	7.5	25
TAIHO PHARMACEUTICAL CO., LTD. US Patent					Assay Description The in vitro inhibitory activity of the compound of the present invention against Syk kinase activity was assayed under the following conditions: the...				US Patent US9145414 (2015) BindingDB Entry DOI: 10.7270/Q2513X18
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM182776 (US9145414, 56) Show SMILES CCn1nc(C)c2cc(Nc3nc(N[C@@H]4CCCC[C@@H]4N)nnc3C(N)=O)ccc12 |r| Show InChI InChI=1S/C20H27N9O/c1-3-29-16-9-8-12(10-13(16)11(2)28-29)23-19-17(18(22)30)26-27-20(25-19)24-15-7-5-4-6-14(15)21/h8-10,14-15H,3-7,21H2,1-2H3,(H2,22,30)(H2,23,24,25,27)/t14-,15+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	7.5	25
TAIHO PHARMACEUTICAL CO., LTD. US Patent					Assay Description The in vitro inhibitory activity of the compound of the present invention against Syk kinase activity was assayed under the following conditions: the...				US Patent US9145414 (2015) BindingDB Entry DOI: 10.7270/Q2513X18
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM182812 (US9145414, 265) Show SMILES Cc1cc(Nc2nc(N[C@@H]3CCCC[C@@H]3N)nnc2C(N)=O)cc2nn(cc12)C(F)F |r| Show InChI InChI=1S/C19H23F2N9O/c1-9-6-10(7-14-11(9)8-30(29-14)18(20)21)24-17-15(16(23)31)27-28-19(26-17)25-13-5-3-2-4-12(13)22/h6-8,12-13,18H,2-5,22H2,1H3,(H2,23,31)(H2,24,25,26,28)/t12-,13+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	7.5	25
TAIHO PHARMACEUTICAL CO., LTD. US Patent					Assay Description The in vitro inhibitory activity of the compound of the present invention against Syk kinase activity was assayed under the following conditions: the...				US Patent US9145414 (2015) BindingDB Entry DOI: 10.7270/Q2513X18
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM182773 (US9145414, 35) Show SMILES N[C@H]1CCCC[C@H]1Nc1nnc(C(N)=O)c(Nc2cccc3n(CCF)ccc23)n1 |r| Show InChI InChI=1S/C20H25FN8O/c21-9-11-29-10-8-12-14(6-3-7-16(12)29)24-19-17(18(23)30)27-28-20(26-19)25-15-5-2-1-4-13(15)22/h3,6-8,10,13,15H,1-2,4-5,9,11,22H2,(H2,23,30)(H2,24,25,26,28)/t13-,15+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.510	n/a	n/a	n/a	n/a	7.5	25
TAIHO PHARMACEUTICAL CO., LTD. US Patent					Assay Description The in vitro inhibitory activity of the compound of the present invention against Syk kinase activity was assayed under the following conditions: the...				US Patent US9145414 (2015) BindingDB Entry DOI: 10.7270/Q2513X18
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM60658 (US9145414, 5) Show SMILES CCn1ncc2cc(Nc3nc(N[C@@H]4CCCC[C@@H]4N)nnc3C(N)=O)ccc12 |r| Show InChI InChI=1S/C19H25N9O/c1-2-28-15-8-7-12(9-11(15)10-22-28)23-18-16(17(21)29)26-27-19(25-18)24-14-6-4-3-5-13(14)20/h7-10,13-14H,2-6,20H2,1H3,(H2,21,29)(H2,23,24,25,27)/t13-,14+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.520	n/a	n/a	n/a	n/a	7.4	25
TAIHO PHARMACEUTICAL CO., LTD. US Patent					Assay Description The in vitro inhibitory activity of the compound against Aurora B kinase activity was assayed with reference to a method described in patent public...				US Patent US9145414 (2015) BindingDB Entry DOI: 10.7270/Q2513X18
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM182777 (US9145414, 57) Show SMILES N[C@H]1CCCC[C@H]1Nc1nnc(C(N)=O)c(Nc2ccc3nn(cc3c2)C(F)F)n1 |r| Show InChI InChI=1S/C18H21F2N9O/c19-17(20)29-8-9-7-10(5-6-12(9)28-29)23-16-14(15(22)30)26-27-18(25-16)24-13-4-2-1-3-11(13)21/h5-8,11,13,17H,1-4,21H2,(H2,22,30)(H2,23,24,25,27)/t11-,13+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.520	n/a	n/a	n/a	n/a	7.5	25
TAIHO PHARMACEUTICAL CO., LTD. US Patent					Assay Description The in vitro inhibitory activity of the compound of the present invention against Syk kinase activity was assayed under the following conditions: the...				US Patent US9145414 (2015) BindingDB Entry DOI: 10.7270/Q2513X18
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM182768 (US9145414, 24) Show SMILES N[C@H]1CCCC[C@H]1Nc1nnc(C(N)=O)c(Nc2ccc3cn(nc3c2)C(F)F)n1 |r| Show InChI InChI=1S/C18H21F2N9O/c19-17(20)29-8-9-5-6-10(7-13(9)28-29)23-16-14(15(22)30)26-27-18(25-16)24-12-4-2-1-3-11(12)21/h5-8,11-12,17H,1-4,21H2,(H2,22,30)(H2,23,24,25,27)/t11-,12+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.530	n/a	n/a	n/a	n/a	7.5	25
TAIHO PHARMACEUTICAL CO., LTD. US Patent					Assay Description The in vitro inhibitory activity of the compound of the present invention against Syk kinase activity was assayed under the following conditions: the...				US Patent US9145414 (2015) BindingDB Entry DOI: 10.7270/Q2513X18
					More data for this Ligand-Target Pair

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