Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Dihydrofolate reductase (Bacillus anthracis) | BDBM18050 (2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)a...) | PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 15 | n/a | n/a | n/a | n/a | 7.1 | 22 |
University of Tennessee at Knoxville | Assay Description Activity was measured as a change in absorbance over time at a wavelength of 340 nm (A340), so as to monitor the disappearance of NADPH. After incuba... | J Med Chem 50: 4374-81 (2007) Article DOI: 10.1021/jm070319v BindingDB Entry DOI: 10.7270/Q2PG1Q0Q | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Dihydrofolate reductase (Bacillus anthracis) | BDBM18068 (2-amino-6-(methylamino)-5-nitropyrimidin-4-ol | CH...) | PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 1.04E+5 | n/a | n/a | n/a | n/a | 7.1 | 22 |
University of Tennessee at Knoxville | Assay Description Activity was measured as a change in absorbance over time at a wavelength of 340 nm (A340), so as to monitor the disappearance of NADPH. After incuba... | J Med Chem 50: 4374-81 (2007) Article DOI: 10.1021/jm070319v BindingDB Entry DOI: 10.7270/Q2PG1Q0Q | |||||||||||
More data for this Ligand-Target Pair |