Found 310 hits with Last Name = 'smith' and Initial = 'bm' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM50361235
(CHEMBL1934525)Show SMILES C[C@@H]1CCCN1CCc1ccc(cc1)-c1ccc(cc1)S(=O)(=O)CC1CCOCC1 |r| Show InChI InChI=1S/C25H33NO3S/c1-20-3-2-15-26(20)16-12-21-4-6-23(7-5-21)24-8-10-25(11-9-24)30(27,28)19-22-13-17-29-18-14-22/h4-11,20,22H,2-3,12-19H2,1H3/t20-/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
| Article PubMed
| 0.170 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Arena Pharmaceuticals
Curated by ChEMBL
| Assay Description Displacement of N-[3H]-methylhistamine from histamine H3 receptor in rat cortex membranes |
Bioorg Med Chem Lett 22: 71-5 (2011)
Article DOI: 10.1016/j.bmcl.2011.11.075 BindingDB Entry DOI: 10.7270/Q27M08C7 |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM50352357
(CHEMBL558655)Show SMILES CC1CCCN1CCc1ccc(cc1)-c1ccc(cc1)S(=O)(=O)NCc1ccncc1 Show InChI InChI=1S/C25H29N3O2S/c1-20-3-2-17-28(20)18-14-21-4-6-23(7-5-21)24-8-10-25(11-9-24)31(29,30)27-19-22-12-15-26-16-13-22/h4-13,15-16,20,27H,2-3,14,17-19H2,1H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 0.182 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Arena Pharmaceuticals
Curated by ChEMBL
| Assay Description Displacement of N-[3H]methylhistamine from histamine H3 receptor in rat cortex membrane |
J Med Chem 52: 5603-11 (2009)
Article DOI: 10.1021/jm900857n BindingDB Entry DOI: 10.7270/Q2KW5G2F |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM50361237
(CHEMBL1934527)Show SMILES C[C@@H]1CCCN1CCc1ccc(cc1)-c1ccc(cc1)S(=O)(=O)CC1CCCCO1 |r| Show InChI InChI=1S/C25H33NO3S/c1-20-5-4-16-26(20)17-15-21-7-9-22(10-8-21)23-11-13-25(14-12-23)30(27,28)19-24-6-2-3-18-29-24/h7-14,20,24H,2-6,15-19H2,1H3/t20-,24?/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
| Article PubMed
| 0.200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Arena Pharmaceuticals
Curated by ChEMBL
| Assay Description Displacement of N-[3H]-methylhistamine from histamine H3 receptor in rat cortex membranes |
Bioorg Med Chem Lett 22: 71-5 (2011)
Article DOI: 10.1016/j.bmcl.2011.11.075 BindingDB Entry DOI: 10.7270/Q27M08C7 |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM50352358
(CHEMBL558456)Show SMILES CC1CCCN1CCc1ccc(cc1)-c1ccc(cc1)S(=O)(=O)NCc1ccccc1 Show InChI InChI=1S/C26H30N2O2S/c1-21-6-5-18-28(21)19-17-22-9-11-24(12-10-22)25-13-15-26(16-14-25)31(29,30)27-20-23-7-3-2-4-8-23/h2-4,7-16,21,27H,5-6,17-20H2,1H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 0.295 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Arena Pharmaceuticals
Curated by ChEMBL
| Assay Description Displacement of N-[3H]methylhistamine from histamine H3 receptor in rat cortex membrane |
J Med Chem 52: 5603-11 (2009)
Article DOI: 10.1021/jm900857n BindingDB Entry DOI: 10.7270/Q2KW5G2F |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM50414743
(CHEMBL564803)Show SMILES CC1CCCN1CCc1ccc(cc1)-c1ccc(cc1)S(=O)(=O)N1Cc2ccccc2C1 Show InChI InChI=1S/C27H30N2O2S/c1-21-5-4-17-28(21)18-16-22-8-10-23(11-9-22)24-12-14-27(15-13-24)32(30,31)29-19-25-6-2-3-7-26(25)20-29/h2-3,6-15,21H,4-5,16-20H2,1H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| 0.501 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Arena Pharmaceuticals
Curated by ChEMBL
| Assay Description Displacement of N-[3H]methylhistamine from histamine H3 receptor in rat cortex membrane |
J Med Chem 52: 5603-11 (2009)
Article DOI: 10.1021/jm900857n BindingDB Entry DOI: 10.7270/Q2KW5G2F |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM50361226
(CHEMBL1934356)Show SMILES CCCS(=O)(=O)c1ccc(cc1)-c1ccc(CCN2CCC[C@H]2C)cc1 |r| Show InChI InChI=1S/C22H29NO2S/c1-3-17-26(24,25)22-12-10-21(11-13-22)20-8-6-19(7-9-20)14-16-23-15-4-5-18(23)2/h6-13,18H,3-5,14-17H2,1-2H3/t18-/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 0.600 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Arena Pharmaceuticals
Curated by ChEMBL
| Assay Description Displacement of N-[3H]-methylhistamine from histamine H3 receptor in rat cortex membranes |
Bioorg Med Chem Lett 22: 71-5 (2011)
Article DOI: 10.1016/j.bmcl.2011.11.075 BindingDB Entry DOI: 10.7270/Q27M08C7 |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM50361228
(CHEMBL1934358)Show SMILES C[C@@H]1CCCN1CCc1ccc(cc1)-c1ccc(cc1)S(=O)(=O)Cc1ccccc1 |r| Show InChI InChI=1S/C26H29NO2S/c1-21-6-5-18-27(21)19-17-22-9-11-24(12-10-22)25-13-15-26(16-14-25)30(28,29)20-23-7-3-2-4-8-23/h2-4,7-16,21H,5-6,17-20H2,1H3/t21-/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 0.600 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Arena Pharmaceuticals
Curated by ChEMBL
| Assay Description Displacement of N-[3H]-methylhistamine from histamine H3 receptor in rat cortex membranes |
Bioorg Med Chem Lett 22: 71-5 (2011)
Article DOI: 10.1016/j.bmcl.2011.11.075 BindingDB Entry DOI: 10.7270/Q27M08C7 |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM50352354
(CHEMBL554506)Show SMILES COC1CCN(CC1)S(=O)(=O)c1ccc(cc1)-c1ccc(CCN2CCCC2C)cc1 Show InChI InChI=1S/C25H34N2O3S/c1-20-4-3-16-26(20)17-13-21-5-7-22(8-6-21)23-9-11-25(12-10-23)31(28,29)27-18-14-24(30-2)15-19-27/h5-12,20,24H,3-4,13-19H2,1-2H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 0.646 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Arena Pharmaceuticals
Curated by ChEMBL
| Assay Description Displacement of N-[3H]methylhistamine from histamine H3 receptor in rat cortex membrane |
J Med Chem 52: 5603-11 (2009)
Article DOI: 10.1021/jm900857n BindingDB Entry DOI: 10.7270/Q2KW5G2F |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM50361233
(CHEMBL1934523)Show SMILES COCCCS(=O)(=O)c1ccc(cc1)-c1ccc(CCN2CCC[C@H]2C)cc1 |r| Show InChI InChI=1S/C23H31NO3S/c1-19-5-3-15-24(19)16-14-20-6-8-21(9-7-20)22-10-12-23(13-11-22)28(25,26)18-4-17-27-2/h6-13,19H,3-5,14-18H2,1-2H3/t19-/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 0.700 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Arena Pharmaceuticals
Curated by ChEMBL
| Assay Description Displacement of N-[3H]-methylhistamine from histamine H3 receptor in rat cortex membranes |
Bioorg Med Chem Lett 22: 71-5 (2011)
Article DOI: 10.1016/j.bmcl.2011.11.075 BindingDB Entry DOI: 10.7270/Q27M08C7 |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM50361234
(CHEMBL1934524)Show SMILES C[C@@H]1CCCN1CCc1ccc(cc1)-c1ccc(cc1)S(=O)(=O)CCCO |r| Show InChI InChI=1S/C22H29NO3S/c1-18-4-2-14-23(18)15-13-19-5-7-20(8-6-19)21-9-11-22(12-10-21)27(25,26)17-3-16-24/h5-12,18,24H,2-4,13-17H2,1H3/t18-/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 0.800 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Arena Pharmaceuticals
Curated by ChEMBL
| Assay Description Displacement of N-[3H]-methylhistamine from histamine H3 receptor in rat cortex membranes |
Bioorg Med Chem Lett 22: 71-5 (2011)
Article DOI: 10.1016/j.bmcl.2011.11.075 BindingDB Entry DOI: 10.7270/Q27M08C7 |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM50361225
(CHEMBL1934355)Show SMILES CCS(=O)(=O)c1ccc(cc1)-c1ccc(CCN2CCC[C@H]2C)cc1 |r| Show InChI InChI=1S/C21H27NO2S/c1-3-25(23,24)21-12-10-20(11-13-21)19-8-6-18(7-9-19)14-16-22-15-4-5-17(22)2/h6-13,17H,3-5,14-16H2,1-2H3/t17-/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 0.900 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Arena Pharmaceuticals
Curated by ChEMBL
| Assay Description Displacement of N-[3H]-methylhistamine from histamine H3 receptor in rat cortex membranes |
Bioorg Med Chem Lett 22: 71-5 (2011)
Article DOI: 10.1016/j.bmcl.2011.11.075 BindingDB Entry DOI: 10.7270/Q27M08C7 |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM50352355
(CHEMBL560140)Show SMILES CC1CCCN1CCc1ccc(cc1)-c1ccc(cc1)S(=O)(=O)N1CCS(=O)(=O)CC1 Show InChI InChI=1S/C23H30N2O4S2/c1-19-3-2-13-24(19)14-12-20-4-6-21(7-5-20)22-8-10-23(11-9-22)31(28,29)25-15-17-30(26,27)18-16-25/h4-11,19H,2-3,12-18H2,1H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| 0.933 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Arena Pharmaceuticals
Curated by ChEMBL
| Assay Description Displacement of N-[3H]methylhistamine from histamine H3 receptor in rat cortex membrane |
J Med Chem 52: 5603-11 (2009)
Article DOI: 10.1021/jm900857n BindingDB Entry DOI: 10.7270/Q2KW5G2F |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Homo sapiens (Human)) | BDBM50297367
(4'-[2-((R)-2-Methyl-pyrrolidin-1-yl)-ethyl]-biphen...)Show SMILES C[C@@H]1CCCN1CCc1ccc(cc1)-c1ccc(cc1)S(=O)(=O)NC1CCOCC1 |r| Show InChI InChI=1S/C24H32N2O3S/c1-19-3-2-15-26(19)16-12-20-4-6-21(7-5-20)22-8-10-24(11-9-22)30(27,28)25-23-13-17-29-18-14-23/h4-11,19,23,25H,2-3,12-18H2,1H3/t19-/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Arena Pharmaceuticals
Curated by ChEMBL
| Assay Description Inverse agonist activity against human histamine H3 receptor by [35S]GTPgamma binding assay |
J Med Chem 52: 5603-11 (2009)
Article DOI: 10.1021/jm900857n BindingDB Entry DOI: 10.7270/Q2KW5G2F |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Homo sapiens (Human)) | BDBM50297366
(4'-[2-((R)-2-Methyl-pyrrolidin-1-yl)-ethyl]-biphen...)Show SMILES CCNS(=O)(=O)c1ccc(cc1)-c1ccc(CCN2CCC[C@H]2C)cc1 |r| Show InChI InChI=1S/C21H28N2O2S/c1-3-22-26(24,25)21-12-10-20(11-13-21)19-8-6-18(7-9-19)14-16-23-15-4-5-17(23)2/h6-13,17,22H,3-5,14-16H2,1-2H3/t17-/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Arena Pharmaceuticals
Curated by ChEMBL
| Assay Description Inverse agonist activity against human histamine H3 receptor by [35S]GTPgamma binding assay |
J Med Chem 52: 5603-11 (2009)
Article DOI: 10.1021/jm900857n BindingDB Entry DOI: 10.7270/Q2KW5G2F |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM50361232
(CHEMBL1934522)Show SMILES CCOCCS(=O)(=O)c1ccc(cc1)-c1ccc(CCN2CCC[C@H]2C)cc1 |r| Show InChI InChI=1S/C23H31NO3S/c1-3-27-17-18-28(25,26)23-12-10-22(11-13-23)21-8-6-20(7-9-21)14-16-24-15-4-5-19(24)2/h6-13,19H,3-5,14-18H2,1-2H3/t19-/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Arena Pharmaceuticals
Curated by ChEMBL
| Assay Description Displacement of N-[3H]-methylhistamine from histamine H3 receptor in rat cortex membranes |
Bioorg Med Chem Lett 22: 71-5 (2011)
Article DOI: 10.1016/j.bmcl.2011.11.075 BindingDB Entry DOI: 10.7270/Q27M08C7 |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Homo sapiens (Human)) | BDBM50297368
(4-{4'-[2-((R)-2-Methyl-pyrrolidin-1-yl)-ethyl]-bip...)Show SMILES C[C@@H]1CCCN1CCc1ccc(cc1)-c1ccc(cc1)S(=O)(=O)N1CCOCC1 |r| Show InChI InChI=1S/C23H30N2O3S/c1-19-3-2-13-24(19)14-12-20-4-6-21(7-5-20)22-8-10-23(11-9-22)29(26,27)25-15-17-28-18-16-25/h4-11,19H,2-3,12-18H2,1H3/t19-/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Arena Pharmaceuticals
Curated by ChEMBL
| Assay Description Inverse agonist activity against human histamine H3 receptor by [35S]GTPgamma binding assay |
J Med Chem 52: 5603-11 (2009)
Article DOI: 10.1021/jm900857n BindingDB Entry DOI: 10.7270/Q2KW5G2F |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM50361229
(CHEMBL1934519)Show SMILES C[C@@H]1CCCN1CCc1ccc(cc1)-c1ccc(cc1)S(=O)(=O)C1CCCC1 |r| Show InChI InChI=1S/C24H31NO2S/c1-19-5-4-17-25(19)18-16-20-8-10-21(11-9-20)22-12-14-24(15-13-22)28(26,27)23-6-2-3-7-23/h8-15,19,23H,2-7,16-18H2,1H3/t19-/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Arena Pharmaceuticals
Curated by ChEMBL
| Assay Description Displacement of N-[3H]-methylhistamine from histamine H3 receptor in rat cortex membranes |
Bioorg Med Chem Lett 22: 71-5 (2011)
Article DOI: 10.1016/j.bmcl.2011.11.075 BindingDB Entry DOI: 10.7270/Q27M08C7 |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM50361236
(CHEMBL1934526)Show SMILES C[C@@H]1CCCN1CCc1ccc(cc1)-c1ccc(cc1)S(=O)(=O)C1CCOCC1 |r| Show InChI InChI=1S/C24H31NO3S/c1-19-3-2-15-25(19)16-12-20-4-6-21(7-5-20)22-8-10-23(11-9-22)29(26,27)24-13-17-28-18-14-24/h4-11,19,24H,2-3,12-18H2,1H3/t19-/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 1.10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Arena Pharmaceuticals
Curated by ChEMBL
| Assay Description Displacement of N-[3H]-methylhistamine from histamine H3 receptor in rat cortex membranes |
Bioorg Med Chem Lett 22: 71-5 (2011)
Article DOI: 10.1016/j.bmcl.2011.11.075 BindingDB Entry DOI: 10.7270/Q27M08C7 |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM50361231
(CHEMBL1934521)Show SMILES C[C@@H]1CCCN1CCc1ccc(cc1)-c1ccc(cc1)S(=O)(=O)CCO |r| Show InChI InChI=1S/C21H27NO3S/c1-17-3-2-13-22(17)14-12-18-4-6-19(7-5-18)20-8-10-21(11-9-20)26(24,25)16-15-23/h4-11,17,23H,2-3,12-16H2,1H3/t17-/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 1.20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Arena Pharmaceuticals
Curated by ChEMBL
| Assay Description Displacement of N-[3H]-methylhistamine from histamine H3 receptor in rat cortex membranes |
Bioorg Med Chem Lett 22: 71-5 (2011)
Article DOI: 10.1016/j.bmcl.2011.11.075 BindingDB Entry DOI: 10.7270/Q27M08C7 |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM50361224
(CHEMBL1934354)Show SMILES C[C@@H]1CCCN1CCc1ccc(cc1)-c1ccc(cc1)S(C)(=O)=O |r| Show InChI InChI=1S/C20H25NO2S/c1-16-4-3-14-21(16)15-13-17-5-7-18(8-6-17)19-9-11-20(12-10-19)24(2,22)23/h5-12,16H,3-4,13-15H2,1-2H3/t16-/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 1.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Arena Pharmaceuticals
Curated by ChEMBL
| Assay Description Displacement of N-[3H]-methylhistamine from histamine H3 receptor in rat cortex membranes |
Bioorg Med Chem Lett 22: 71-5 (2011)
Article DOI: 10.1016/j.bmcl.2011.11.075 BindingDB Entry DOI: 10.7270/Q27M08C7 |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM50361230
(CHEMBL1934520)Show SMILES COCCS(=O)(=O)c1ccc(cc1)-c1ccc(CCN2CCC[C@H]2C)cc1 |r| Show InChI InChI=1S/C22H29NO3S/c1-18-4-3-14-23(18)15-13-19-5-7-20(8-6-19)21-9-11-22(12-10-21)27(24,25)17-16-26-2/h5-12,18H,3-4,13-17H2,1-2H3/t18-/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 1.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Arena Pharmaceuticals
Curated by ChEMBL
| Assay Description Displacement of N-[3H]-methylhistamine from histamine H3 receptor in rat cortex membranes |
Bioorg Med Chem Lett 22: 71-5 (2011)
Article DOI: 10.1016/j.bmcl.2011.11.075 BindingDB Entry DOI: 10.7270/Q27M08C7 |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM50414742
(CHEMBL560799)Show SMILES CCN(CC)S(=O)(=O)c1ccc(cc1)-c1ccc(CCN2CCCC2C)cc1 Show InChI InChI=1S/C23H32N2O2S/c1-4-25(5-2)28(26,27)23-14-12-22(13-15-23)21-10-8-20(9-11-21)16-18-24-17-6-7-19(24)3/h8-15,19H,4-7,16-18H2,1-3H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 1.41 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Arena Pharmaceuticals
Curated by ChEMBL
| Assay Description Displacement of N-[3H]methylhistamine from histamine H3 receptor in rat cortex membrane |
J Med Chem 52: 5603-11 (2009)
Article DOI: 10.1021/jm900857n BindingDB Entry DOI: 10.7270/Q2KW5G2F |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM50297368
(4-{4'-[2-((R)-2-Methyl-pyrrolidin-1-yl)-ethyl]-bip...)Show SMILES C[C@@H]1CCCN1CCc1ccc(cc1)-c1ccc(cc1)S(=O)(=O)N1CCOCC1 |r| Show InChI InChI=1S/C23H30N2O3S/c1-19-3-2-13-24(19)14-12-20-4-6-21(7-5-20)22-8-10-23(11-9-22)29(26,27)25-15-17-28-18-16-25/h4-11,19H,2-3,12-18H2,1H3/t19-/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 1.58 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Arena Pharmaceuticals
Curated by ChEMBL
| Assay Description Displacement of N-[3H]methylhistamine from histamine H3 receptor in rat cortex membrane |
J Med Chem 52: 5603-11 (2009)
Article DOI: 10.1021/jm900857n BindingDB Entry DOI: 10.7270/Q2KW5G2F |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM50352364
(CHEMBL562629)Show SMILES CC1CCCN1CCc1ccc(cc1)-c1ccc(cc1)S(=O)(=O)N1CCCCC1 Show InChI InChI=1S/C24H32N2O2S/c1-20-6-5-16-25(20)19-15-21-7-9-22(10-8-21)23-11-13-24(14-12-23)29(27,28)26-17-3-2-4-18-26/h7-14,20H,2-6,15-19H2,1H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 1.62 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Arena Pharmaceuticals
Curated by ChEMBL
| Assay Description Displacement of N-[3H]methylhistamine from histamine H3 receptor in rat cortex membrane |
J Med Chem 52: 5603-11 (2009)
Article DOI: 10.1021/jm900857n BindingDB Entry DOI: 10.7270/Q2KW5G2F |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM50297367
(4'-[2-((R)-2-Methyl-pyrrolidin-1-yl)-ethyl]-biphen...)Show SMILES C[C@@H]1CCCN1CCc1ccc(cc1)-c1ccc(cc1)S(=O)(=O)NC1CCOCC1 |r| Show InChI InChI=1S/C24H32N2O3S/c1-19-3-2-15-26(19)16-12-20-4-6-21(7-5-20)22-8-10-24(11-9-22)30(27,28)25-23-13-17-29-18-14-23/h4-11,19,23,25H,2-3,12-18H2,1H3/t19-/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 1.78 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Arena Pharmaceuticals
Curated by ChEMBL
| Assay Description Displacement of N-[3H]methylhistamine from histamine H3 receptor in rat cortex membrane |
J Med Chem 52: 5603-11 (2009)
Article DOI: 10.1021/jm900857n BindingDB Entry DOI: 10.7270/Q2KW5G2F |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM50352359
(CHEMBL552279)Show SMILES CC1CCCN1CCc1ccc(cc1)-c1ccc(cc1)S(=O)(=O)Nc1ccccc1 Show InChI InChI=1S/C25H28N2O2S/c1-20-6-5-18-27(20)19-17-21-9-11-22(12-10-21)23-13-15-25(16-14-23)30(28,29)26-24-7-3-2-4-8-24/h2-4,7-16,20,26H,5-6,17-19H2,1H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| 1.86 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Arena Pharmaceuticals
Curated by ChEMBL
| Assay Description Displacement of N-[3H]methylhistamine from histamine H3 receptor in rat cortex membrane |
J Med Chem 52: 5603-11 (2009)
Article DOI: 10.1021/jm900857n BindingDB Entry DOI: 10.7270/Q2KW5G2F |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM50352360
(CHEMBL563118)Show SMILES CC1CCCN1CCc1ccc(cc1)-c1ccc(cc1)S(=O)(=O)NC1CCC1 Show InChI InChI=1S/C23H30N2O2S/c1-18-4-3-16-25(18)17-15-19-7-9-20(10-8-19)21-11-13-23(14-12-21)28(26,27)24-22-5-2-6-22/h7-14,18,22,24H,2-6,15-17H2,1H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 2.29 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Arena Pharmaceuticals
Curated by ChEMBL
| Assay Description Displacement of N-[3H]methylhistamine from histamine H3 receptor in rat cortex membrane |
J Med Chem 52: 5603-11 (2009)
Article DOI: 10.1021/jm900857n BindingDB Entry DOI: 10.7270/Q2KW5G2F |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM50361238
(CHEMBL1934528)Show SMILES COCS(=O)(=O)c1ccc(cc1)-c1ccc(CCN2CCC[C@H]2C)cc1 |r| Show InChI InChI=1S/C21H27NO3S/c1-17-4-3-14-22(17)15-13-18-5-7-19(8-6-18)20-9-11-21(12-10-20)26(23,24)16-25-2/h5-12,17H,3-4,13-16H2,1-2H3/t17-/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 2.44 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Arena Pharmaceuticals
Curated by ChEMBL
| Assay Description Displacement of N-[3H]-methylhistamine from histamine H3 receptor in rat cortex membranes |
Bioorg Med Chem Lett 22: 71-5 (2011)
Article DOI: 10.1016/j.bmcl.2011.11.075 BindingDB Entry DOI: 10.7270/Q27M08C7 |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM50352353
(CHEMBL1823053)Show SMILES C[C@@H]1CCCN1CCc1ccc(cc1)-c1ccc(cc1)S(=O)(=O)N1CCC(O)C1 |r| Show InChI InChI=1S/C23H30N2O3S/c1-18-3-2-14-24(18)15-12-19-4-6-20(7-5-19)21-8-10-23(11-9-21)29(27,28)25-16-13-22(26)17-25/h4-11,18,22,26H,2-3,12-17H2,1H3/t18-,22?/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 2.45 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Arena Pharmaceuticals
Curated by ChEMBL
| Assay Description Displacement of N-[3H]methylhistamine from histamine H3 receptor in rat cortex membrane |
J Med Chem 52: 5603-11 (2009)
Article DOI: 10.1021/jm900857n BindingDB Entry DOI: 10.7270/Q2KW5G2F |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM50352361
(CHEMBL558260)Show SMILES CC1CCCN1CCc1ccc(cc1)-c1ccc(cc1)S(=O)(=O)NCC1CC1 Show InChI InChI=1S/C23H30N2O2S/c1-18-3-2-15-25(18)16-14-19-6-8-21(9-7-19)22-10-12-23(13-11-22)28(26,27)24-17-20-4-5-20/h6-13,18,20,24H,2-5,14-17H2,1H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 2.51 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Arena Pharmaceuticals
Curated by ChEMBL
| Assay Description Displacement of N-[3H]methylhistamine from histamine H3 receptor in rat cortex membrane |
J Med Chem 52: 5603-11 (2009)
Article DOI: 10.1021/jm900857n BindingDB Entry DOI: 10.7270/Q2KW5G2F |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM50361227
(CHEMBL1934357)Show SMILES CC(C)S(=O)(=O)c1ccc(cc1)-c1ccc(CCN2CCC[C@H]2C)cc1 |r| Show InChI InChI=1S/C22H29NO2S/c1-17(2)26(24,25)22-12-10-21(11-13-22)20-8-6-19(7-9-20)14-16-23-15-4-5-18(23)3/h6-13,17-18H,4-5,14-16H2,1-3H3/t18-/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 2.65 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Arena Pharmaceuticals
Curated by ChEMBL
| Assay Description Displacement of N-[3H]-methylhistamine from histamine H3 receptor in rat cortex membranes |
Bioorg Med Chem Lett 22: 71-5 (2011)
Article DOI: 10.1016/j.bmcl.2011.11.075 BindingDB Entry DOI: 10.7270/Q27M08C7 |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Homo sapiens (Human)) | BDBM50297368
(4-{4'-[2-((R)-2-Methyl-pyrrolidin-1-yl)-ethyl]-bip...)Show SMILES C[C@@H]1CCCN1CCc1ccc(cc1)-c1ccc(cc1)S(=O)(=O)N1CCOCC1 |r| Show InChI InChI=1S/C23H30N2O3S/c1-19-3-2-13-24(19)14-12-20-4-6-21(7-5-20)22-8-10-23(11-9-22)29(26,27)25-15-17-28-18-16-25/h4-11,19H,2-3,12-18H2,1H3/t19-/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Arena Pharmaceuticals
Curated by ChEMBL
| Assay Description Binding affinity to human histamine H3 receptor |
J Med Chem 52: 5603-11 (2009)
Article DOI: 10.1021/jm900857n BindingDB Entry DOI: 10.7270/Q2KW5G2F |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM50297369
(4'-[2-((R)-2-Methyl-pyrrolidin-1-yl)-ethyl]-biphen...)Show SMILES COCCNS(=O)(=O)c1ccc(cc1)-c1ccc(CCN2CCC[C@H]2C)cc1 |r| Show InChI InChI=1S/C22H30N2O3S/c1-18-4-3-15-24(18)16-13-19-5-7-20(8-6-19)21-9-11-22(12-10-21)28(25,26)23-14-17-27-2/h5-12,18,23H,3-4,13-17H2,1-2H3/t18-/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Arena Pharmaceuticals
Curated by ChEMBL
| Assay Description Displacement of N-[3H]methylhistamine from histamine H3 receptor in rat cortex membrane |
J Med Chem 52: 5603-11 (2009)
Article DOI: 10.1021/jm900857n BindingDB Entry DOI: 10.7270/Q2KW5G2F |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Homo sapiens (Human)) | BDBM50361233
(CHEMBL1934523)Show SMILES COCCCS(=O)(=O)c1ccc(cc1)-c1ccc(CCN2CCC[C@H]2C)cc1 |r| Show InChI InChI=1S/C23H31NO3S/c1-19-5-3-15-24(19)16-14-20-6-8-21(9-7-20)22-10-12-23(13-11-22)28(25,26)18-4-17-27-2/h6-13,19H,3-5,14-18H2,1-2H3/t19-/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 4.20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Arena Pharmaceuticals
Curated by ChEMBL
| Assay Description Binding affinity to human cloned histamine H3 receptor |
Bioorg Med Chem Lett 22: 71-5 (2011)
Article DOI: 10.1016/j.bmcl.2011.11.075 BindingDB Entry DOI: 10.7270/Q27M08C7 |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM50414741
(CHEMBL550198)Show SMILES CC(C)NS(=O)(=O)c1ccc(cc1)-c1ccc(CCN2CCCC2C)cc1 Show InChI InChI=1S/C22H30N2O2S/c1-17(2)23-27(25,26)22-12-10-21(11-13-22)20-8-6-19(7-9-20)14-16-24-15-4-5-18(24)3/h6-13,17-18,23H,4-5,14-16H2,1-3H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 4.27 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Arena Pharmaceuticals
Curated by ChEMBL
| Assay Description Displacement of N-[3H]methylhistamine from histamine H3 receptor in rat cortex membrane |
J Med Chem 52: 5603-11 (2009)
Article DOI: 10.1021/jm900857n BindingDB Entry DOI: 10.7270/Q2KW5G2F |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM50297366
(4'-[2-((R)-2-Methyl-pyrrolidin-1-yl)-ethyl]-biphen...)Show SMILES CCNS(=O)(=O)c1ccc(cc1)-c1ccc(CCN2CCC[C@H]2C)cc1 |r| Show InChI InChI=1S/C21H28N2O2S/c1-3-22-26(24,25)21-12-10-20(11-13-21)19-8-6-18(7-9-19)14-16-23-15-4-5-17(23)2/h6-13,17,22H,3-5,14-16H2,1-2H3/t17-/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 4.57 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Arena Pharmaceuticals
Curated by ChEMBL
| Assay Description Displacement of N-[3H]methylhistamine from histamine H3 receptor in rat cortex membrane |
J Med Chem 52: 5603-11 (2009)
Article DOI: 10.1021/jm900857n BindingDB Entry DOI: 10.7270/Q2KW5G2F |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM50352363
(CHEMBL558923)Show InChI InChI=1S/C19H24N2O2S/c1-15-3-2-13-21(15)14-12-16-4-6-17(7-5-16)18-8-10-19(11-9-18)24(20,22)23/h4-11,15H,2-3,12-14H2,1H3,(H2,20,22,23) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 4.57 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Arena Pharmaceuticals
Curated by ChEMBL
| Assay Description Displacement of N-[3H]methylhistamine from histamine H3 receptor in rat cortex membrane |
J Med Chem 52: 5603-11 (2009)
Article DOI: 10.1021/jm900857n BindingDB Entry DOI: 10.7270/Q2KW5G2F |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM50352352
(CHEMBL1823054)Show SMILES COCC1CCCN1S(=O)(=O)c1ccc(cc1)-c1ccc(CCN2CCC[C@H]2C)cc1 |r| Show InChI InChI=1S/C25H34N2O3S/c1-20-5-3-16-26(20)18-15-21-7-9-22(10-8-21)23-11-13-25(14-12-23)31(28,29)27-17-4-6-24(27)19-30-2/h7-14,20,24H,3-6,15-19H2,1-2H3/t20-,24?/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 5.13 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Arena Pharmaceuticals
Curated by ChEMBL
| Assay Description Displacement of N-[3H]methylhistamine from histamine H3 receptor in rat cortex membrane |
J Med Chem 52: 5603-11 (2009)
Article DOI: 10.1021/jm900857n BindingDB Entry DOI: 10.7270/Q2KW5G2F |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM50414744
(CHEMBL563191)Show SMILES CC1CCCN1CCc1ccc(cc1)-c1ccc(cc1)S(=O)(=O)NC(C)(C)CO Show InChI InChI=1S/C23H32N2O3S/c1-18-5-4-15-25(18)16-14-19-6-8-20(9-7-19)21-10-12-22(13-11-21)29(27,28)24-23(2,3)17-26/h6-13,18,24,26H,4-5,14-17H2,1-3H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 6.92 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Arena Pharmaceuticals
Curated by ChEMBL
| Assay Description Displacement of N-[3H]methylhistamine from histamine H3 receptor in rat cortex membrane |
J Med Chem 52: 5603-11 (2009)
Article DOI: 10.1021/jm900857n BindingDB Entry DOI: 10.7270/Q2KW5G2F |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Homo sapiens (Human)) | BDBM50297367
(4'-[2-((R)-2-Methyl-pyrrolidin-1-yl)-ethyl]-biphen...)Show SMILES C[C@@H]1CCCN1CCc1ccc(cc1)-c1ccc(cc1)S(=O)(=O)NC1CCOCC1 |r| Show InChI InChI=1S/C24H32N2O3S/c1-19-3-2-15-26(19)16-12-20-4-6-21(7-5-20)22-8-10-24(11-9-22)30(27,28)25-23-13-17-29-18-14-23/h4-11,19,23,25H,2-3,12-18H2,1H3/t19-/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 7 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Arena Pharmaceuticals
Curated by ChEMBL
| Assay Description Binding affinity to human histamine H3 receptor |
J Med Chem 52: 5603-11 (2009)
Article DOI: 10.1021/jm900857n BindingDB Entry DOI: 10.7270/Q2KW5G2F |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM50352356
(CHEMBL561279)Show SMILES CC1CCCN1CCc1ccc(cc1)-c1ccc(cc1)S(=O)(=O)N1C(C)COCC1C Show InChI InChI=1S/C25H34N2O3S/c1-19-5-4-15-26(19)16-14-22-6-8-23(9-7-22)24-10-12-25(13-11-24)31(28,29)27-20(2)17-30-18-21(27)3/h6-13,19-21H,4-5,14-18H2,1-3H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 7.08 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Arena Pharmaceuticals
Curated by ChEMBL
| Assay Description Displacement of N-[3H]methylhistamine from histamine H3 receptor in rat cortex membrane |
J Med Chem 52: 5603-11 (2009)
Article DOI: 10.1021/jm900857n BindingDB Entry DOI: 10.7270/Q2KW5G2F |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM50414740
(CHEMBL563696)Show SMILES CC(C)NS(=O)(=O)c1cccc(c1)-c1ccc(CCN2CCCC2C)cc1 Show InChI InChI=1S/C22H30N2O2S/c1-17(2)23-27(25,26)22-8-4-7-21(16-22)20-11-9-19(10-12-20)13-15-24-14-5-6-18(24)3/h4,7-12,16-18,23H,5-6,13-15H2,1-3H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 7.94 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Arena Pharmaceuticals
Curated by ChEMBL
| Assay Description Displacement of N-[3H]methylhistamine from histamine H3 receptor in rat cortex membrane |
J Med Chem 52: 5603-11 (2009)
Article DOI: 10.1021/jm900857n BindingDB Entry DOI: 10.7270/Q2KW5G2F |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Homo sapiens (Human)) | BDBM50297366
(4'-[2-((R)-2-Methyl-pyrrolidin-1-yl)-ethyl]-biphen...)Show SMILES CCNS(=O)(=O)c1ccc(cc1)-c1ccc(CCN2CCC[C@H]2C)cc1 |r| Show InChI InChI=1S/C21H28N2O2S/c1-3-22-26(24,25)21-12-10-20(11-13-21)19-8-6-18(7-9-19)14-16-23-15-4-5-17(23)2/h6-13,17,22H,3-5,14-16H2,1-2H3/t17-/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 8 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Arena Pharmaceuticals
Curated by ChEMBL
| Assay Description Binding affinity to human histamine H3 receptor |
J Med Chem 52: 5603-11 (2009)
Article DOI: 10.1021/jm900857n BindingDB Entry DOI: 10.7270/Q2KW5G2F |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM50414739
(CHEMBL571676)Show SMILES CCNS(=O)(=O)c1cccc(c1)-c1ccc(CCN2CCCC2C)cc1 Show InChI InChI=1S/C21H28N2O2S/c1-3-22-26(24,25)21-8-4-7-20(16-21)19-11-9-18(10-12-19)13-15-23-14-5-6-17(23)2/h4,7-12,16-17,22H,3,5-6,13-15H2,1-2H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 11.0 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Arena Pharmaceuticals
Curated by ChEMBL
| Assay Description Displacement of N-[3H]methylhistamine from histamine H3 receptor in rat cortex membrane |
J Med Chem 52: 5603-11 (2009)
Article DOI: 10.1021/jm900857n BindingDB Entry DOI: 10.7270/Q2KW5G2F |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM50414738
(CHEMBL550326)Show SMILES CC1CCCN1CCc1ccc(cc1)-c1cccc(c1)S(=O)(=O)N1CCCCC1 Show InChI InChI=1S/C24H32N2O2S/c1-20-7-6-15-25(20)18-14-21-10-12-22(13-11-21)23-8-5-9-24(19-23)29(27,28)26-16-3-2-4-17-26/h5,8-13,19-20H,2-4,6-7,14-18H2,1H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 12.6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Arena Pharmaceuticals
Curated by ChEMBL
| Assay Description Displacement of N-[3H]methylhistamine from histamine H3 receptor in rat cortex membrane |
J Med Chem 52: 5603-11 (2009)
Article DOI: 10.1021/jm900857n BindingDB Entry DOI: 10.7270/Q2KW5G2F |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM50361239
(CHEMBL1934529)Show SMILES COCCS(=O)(=O)c1ccc(cc1)-c1ccc(CCN2CCC[C@@H]2C)cc1 |r| Show InChI InChI=1S/C22H29NO3S/c1-18-4-3-14-23(18)15-13-19-5-7-20(8-6-19)21-9-11-22(12-10-21)27(24,25)17-16-26-2/h5-12,18H,3-4,13-17H2,1-2H3/t18-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 13.2 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Arena Pharmaceuticals
Curated by ChEMBL
| Assay Description Displacement of N-[3H]-methylhistamine from histamine H3 receptor in rat cortex membranes |
Bioorg Med Chem Lett 22: 71-5 (2011)
Article DOI: 10.1016/j.bmcl.2011.11.075 BindingDB Entry DOI: 10.7270/Q27M08C7 |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM50414737
(CHEMBL564844)Show SMILES CCN(CC)S(=O)(=O)c1cccc(c1)-c1ccc(CCN2CCCC2C)cc1 Show InChI InChI=1S/C23H32N2O2S/c1-4-25(5-2)28(26,27)23-10-6-9-22(18-23)21-13-11-20(12-14-21)15-17-24-16-7-8-19(24)3/h6,9-14,18-19H,4-5,7-8,15-17H2,1-3H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 16.2 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Arena Pharmaceuticals
Curated by ChEMBL
| Assay Description Displacement of N-[3H]methylhistamine from histamine H3 receptor in rat cortex membrane |
J Med Chem 52: 5603-11 (2009)
Article DOI: 10.1021/jm900857n BindingDB Entry DOI: 10.7270/Q2KW5G2F |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Homo sapiens (Human)) | BDBM50361233
(CHEMBL1934523)Show SMILES COCCCS(=O)(=O)c1ccc(cc1)-c1ccc(CCN2CCC[C@H]2C)cc1 |r| Show InChI InChI=1S/C23H31NO3S/c1-19-5-3-15-24(19)16-14-20-6-8-21(9-7-20)22-10-12-23(13-11-22)28(25,26)18-4-17-27-2/h6-13,19H,3-5,14-18H2,1-2H3/t19-/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 0.700 | n/a | n/a | n/a | n/a | n/a | n/a |
Arena Pharmaceuticals
Curated by ChEMBL
| Assay Description Inverse agonist activity at human cloned histamine H3 receptor by [35S]GTPgammaS binding assay |
Bioorg Med Chem Lett 22: 71-5 (2011)
Article DOI: 10.1016/j.bmcl.2011.11.075 BindingDB Entry DOI: 10.7270/Q27M08C7 |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 2A
(Homo sapiens (Human)) | BDBM246305
(US9434692, 52)Show SMILES Cc1[nH]nc(C(=O)N2CCN(CC(=O)c3ccc(F)cc3)CC2)c1Br Show InChI InChI=1S/C17H18BrFN4O2/c1-11-15(18)16(21-20-11)17(25)23-8-6-22(7-9-23)10-14(24)12-2-4-13(19)5-3-12/h2-5H,6-10H2,1H3,(H,20,21) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 4.60 | n/a | n/a | n/a | n/a | 7.4 | 25 |
Arena Pharmaceuticals, Inc.
US Patent
| Assay Description Radioligand binding assays for human 5-HT2A serotonin receptor was conducted using the 5-HT2 agonist [125I]DOI as radioligand. To define nonspecific ... |
US Patent US9434692 (2016)
BindingDB Entry DOI: 10.7270/Q2FJ2FQQ |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 2A
(Homo sapiens (Human)) | BDBM246306
(US9434692, 66)Show SMILES Cn1nc(cc1-c1ccco1)C(=O)N1CCN(CC(=O)c2ccc(F)cc2)CC1 Show InChI InChI=1S/C21H21FN4O3/c1-24-18(20-3-2-12-29-20)13-17(23-24)21(28)26-10-8-25(9-11-26)14-19(27)15-4-6-16(22)7-5-15/h2-7,12-13H,8-11,14H2,1H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 4.80 | n/a | n/a | n/a | n/a | 7.4 | 25 |
Arena Pharmaceuticals, Inc.
US Patent
| Assay Description Radioligand binding assays for human 5-HT2A serotonin receptor was conducted using the 5-HT2 agonist [125I]DOI as radioligand. To define nonspecific ... |
US Patent US9434692 (2016)
BindingDB Entry DOI: 10.7270/Q2FJ2FQQ |
More data for this Ligand-Target Pair | |