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Compile Data Set for Download or QSAR

Found 117 hits with Last Name = 'smith' and Initial = 'rt'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Glucocorticoid receptor


(RAT)		BDBM50577704
PNG
(CHEMBL4863316)
Show SMILES [H][C@@]1(CCCC2=Cc3c(C[C@]12C)cnn3-c1ccc(OC)cc1)[C@H](C)O |r,t:5|
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n/an/a 0.158n/an/an/an/an/an/a


TBA

Assay Description
Agonist activity at glucocorticoid receptor in rat INS-1 832/13 cells transfected with CCL2-promoter luciferase plasmid construct assessed as reducti...

Citation and Details

Article DOI: 10.1021/acsmedchemlett.1c00379
BindingDB Entry DOI: 10.7270/Q2VM4H3N
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(RAT)		BDBM50577694
PNG
(CHEMBL4877227)
Show SMILES [H][C@@]1(CCCC2=Cc3c(C[C@]12C)cnn3-c1ccc(C)cc1)[C@H](C)O |r,t:5|
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n/an/a 0.200n/an/an/an/an/an/a


TBA

Assay Description
Agonist activity at glucocorticoid receptor in rat INS-1 832/13 cells transfected with CCL2-promoter luciferase plasmid construct assessed as reducti...

Citation and Details

Article DOI: 10.1021/acsmedchemlett.1c00379
BindingDB Entry DOI: 10.7270/Q2VM4H3N
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(RAT)		BDBM19205
PNG
((1R)-1-[(4aR,5S)-1-(4-fluorophenyl)-4a-methyl-1H,4...)
Show SMILES [H][C@@]1(CCCC2=Cc3c(C[C@]12C)cnn3-c1ccc(F)cc1)[C@@H](O)C(C)(C)C |r,t:5|
Show InChI InChI=1S/C23H29FN2O/c1-22(2,3)21(27)19-7-5-6-16-12-20-15(13-23(16,19)4)14-25-26(20)18-10-8-17(24)9-11-18/h8-12,14,19,21,27H,5-7,13H2,1-4H3/t19-,21-,23+/m1/s1
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n/an/a 0.251n/an/an/an/an/an/a


TBA

Assay Description
Agonist activity at glucocorticoid receptor in rat INS-1 832/13 cells transfected with CCL2-promoter luciferase plasmid construct assessed as reducti...

Citation and Details

Article DOI: 10.1021/acsmedchemlett.1c00379
BindingDB Entry DOI: 10.7270/Q2VM4H3N
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(RAT)		BDBM50577691
PNG
(CHEMBL4850526)
Show SMILES [H][C@@]1(CCCC2=Cc3c(C[C@]12C)cnn3-c1ccc(F)cc1)[C@](C)(O)c1cc(F)c(F)c(OC)c1 |r,t:5|
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n/an/a 2n/an/an/an/an/an/a


TBA

Assay Description
Agonist activity at glucocorticoid receptor in rat INS-1 832/13 cells transfected with CCL2-promoter luciferase plasmid construct assessed as reducti...

Citation and Details

Article DOI: 10.1021/acsmedchemlett.1c00379
BindingDB Entry DOI: 10.7270/Q2VM4H3N
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(RAT)		BDBM50577710
PNG
(CHEMBL4857046)
Show SMILES [H][C@@]1(CCCC2=Cc3c(CC12)cnn3-c1ccc(OC)cc1)[C@@H](O)c1cc(F)c(F)c(OC)c1 |r,t:5|
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n/an/a 3.20n/an/an/an/an/an/a


TBA

Assay Description
Agonist activity at glucocorticoid receptor in rat INS-1 832/13 cells transfected with CCL2-promoter luciferase plasmid construct assessed as reducti...

Citation and Details

Article DOI: 10.1021/acsmedchemlett.1c00379
BindingDB Entry DOI: 10.7270/Q2VM4H3N
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(RAT)		BDBM19217
PNG
((R)-[(4aR,5S)-1-(4-fluorophenyl)-4a-methyl-1H,4H,4...)
Show SMILES [H][C@@]1(CCCC2=Cc3c(C[C@]12C)cnn3-c1ccc(F)cc1)[C@@H](O)c1ccsc1 |r,t:5|
Show InChI InChI=1S/C23H23FN2OS/c1-23-12-16-13-25-26(19-7-5-18(24)6-8-19)21(16)11-17(23)3-2-4-20(23)22(27)15-9-10-28-14-15/h5-11,13-14,20,22,27H,2-4,12H2,1H3/t20-,22+,23+/m1/s1
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n/an/a 5n/an/an/an/an/an/a


TBA

Assay Description
Agonist activity at glucocorticoid receptor in rat INS-1 832/13 cells transfected with CCL2-promoter luciferase plasmid construct assessed as reducti...

Citation and Details

Article DOI: 10.1021/acsmedchemlett.1c00379
BindingDB Entry DOI: 10.7270/Q2VM4H3N
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(RAT)		BDBM19201
PNG
((1S)-1-[(4aR,5S)-1-(4-fluorophenyl)-4a-methyl-1H,4...)
Show SMILES [H][C@@]1(CCCC2=Cc3c(C[C@]12C)cnn3-c1ccc(F)cc1)[C@](C)(O)c1ccc(F)cc1 |r,t:5|
Show InChI InChI=1S/C26H26F2N2O/c1-25-15-17-16-29-30(22-12-10-21(28)11-13-22)23(17)14-19(25)4-3-5-24(25)26(2,31)18-6-8-20(27)9-7-18/h6-14,16,24,31H,3-5,15H2,1-2H3/t24-,25-,26+/m0/s1
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TBA

Assay Description
Agonist activity at glucocorticoid receptor in rat INS-1 832/13 cells transfected with CCL2-promoter luciferase plasmid construct assessed as reducti...

Citation and Details

Article DOI: 10.1021/acsmedchemlett.1c00379
BindingDB Entry DOI: 10.7270/Q2VM4H3N
More data for this
Ligand-Target Pair
Misshapen-like kinase 1


(Homo sapiens (Human))		BDBM50361467
PNG
(CHEMBL1938400)
Show SMILES CC(C)(C)c1cc(NC(=O)NCc2ccccc2Sc2ccc3nnc(-c4ccccc4SCCO)n3c2)n(n1)-c1ccc(O)c(Cl)c1
Show InChI InChI=1S/C35H34ClN7O3S2/c1-35(2,3)30-19-32(43(41-30)23-12-14-27(45)26(36)18-23)38-34(46)37-20-22-8-4-6-10-28(22)48-24-13-15-31-39-40-33(42(31)21-24)25-9-5-7-11-29(25)47-17-16-44/h4-15,18-19,21,44-45H,16-17,20H2,1-3H3,(H2,37,38,46)
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n/an/a 6n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of MINK

J Med Chem 54: 7797-814 (2011)


Article DOI: 10.1021/jm200677b
BindingDB Entry DOI: 10.7270/Q2HX1D4Q
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(RAT)		BDBM19203
PNG
((1S)-1-[(4aR,5S)-1-(4-fluorophenyl)-4a-methyl-1H,4...)
Show SMILES [H][C@@]1(CCCC2=Cc3c(C[C@]12C)cnn3-c1ccc(F)cc1)[C@H](C)O |r,t:5|
Show InChI InChI=1S/C20H23FN2O/c1-13(24)18-5-3-4-15-10-19-14(11-20(15,18)2)12-22-23(19)17-8-6-16(21)7-9-17/h6-10,12-13,18,24H,3-5,11H2,1-2H3/t13-,18+,20-/m0/s1
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n/an/a 6.30n/an/an/an/an/an/a


TBA

Assay Description
Agonist activity at glucocorticoid receptor in rat INS-1 832/13 cells transfected with CCL2-promoter luciferase plasmid construct assessed as reducti...

Citation and Details

Article DOI: 10.1021/acsmedchemlett.1c00379
BindingDB Entry DOI: 10.7270/Q2VM4H3N
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(RAT)		BDBM50577692
PNG
(CHEMBL4872787)
Show SMILES [H][C@@]1(CCCC2=Cc3c(C[C@]12C)cnn3-c1ccc(F)cc1)[C@@](C)(O)c1ccsc1 |r,t:5|
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n/an/a 6.30n/an/an/an/an/an/a


TBA

Assay Description
Agonist activity at glucocorticoid receptor in rat INS-1 832/13 cells transfected with CCL2-promoter luciferase plasmid construct assessed as reducti...

Citation and Details

Article DOI: 10.1021/acsmedchemlett.1c00379
BindingDB Entry DOI: 10.7270/Q2VM4H3N
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(RAT)		BDBM18207
PNG
((1R,2S,10S,11S,13R,14R,15S,17S)-1-fluoro-14,17-dih...)
Show SMILES [H][C@@]12C[C@@H](C)[C@](O)(C(=O)CO)[C@@]1(C)C[C@H](O)[C@@]1(F)[C@@]2([H])CCC2=CC(=O)C=C[C@]12C |c:28,t:24|
Show InChI InChI=1S/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,17+,19+,20+,21+,22+/m1/s1
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n/an/a 6.30n/an/an/an/an/an/a


TBA

Assay Description
Agonist activity at glucocorticoid receptor in rat INS-1 832/13 cells transfected with CCL2-promoter luciferase plasmid construct assessed as reducti...

Citation and Details

Article DOI: 10.1021/acsmedchemlett.1c00379
BindingDB Entry DOI: 10.7270/Q2VM4H3N
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Amiloride-sensitive sodium channel subunit alpha


(Homo sapiens (Human))		BDBM50190466
PNG
(CHEMBL212431 | N-(3,5-diamino-6-chloropyrazine-2-c...)
Show SMILES NC(NC(=O)c1nc(Cl)c(N)nc1N)=NCCCCc1ccc(OCCCO)cc1 |w:14.15|
Show InChI InChI=1S/C19H26ClN7O3/c20-15-17(22)26-16(21)14(25-15)18(29)27-19(23)24-9-2-1-4-12-5-7-13(8-6-12)30-11-3-10-28/h5-8,28H,1-4,9-11H2,(H4,21,22,26)(H3,23,24,27,29)
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n/an/a 7n/an/an/an/an/an/a



Parion Sciences Inc.

Curated by ChEMBL


Assay Description
Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assay

J Med Chem 49: 4098-115 (2006)


Article DOI: 10.1021/jm051134w
BindingDB Entry DOI: 10.7270/Q2FT8KNH
More data for this
Ligand-Target Pair
Amiloride-sensitive sodium channel subunit alpha


(Homo sapiens (Human))		BDBM50190487
PNG
(CHEMBL212531 | N-(3,5-diamino-6-chloropyrazine-2-c...)
Show SMILES NC(NC(=O)c1nc(Cl)c(N)nc1N)=NCCCCc1ccc(OC[C@@H](O)CO)cc1 |w:14.15|
Show InChI InChI=1S/C19H26ClN7O4/c20-15-17(22)26-16(21)14(25-15)18(30)27-19(23)24-8-2-1-3-11-4-6-13(7-5-11)31-10-12(29)9-28/h4-7,12,28-29H,1-3,8-10H2,(H4,21,22,26)(H3,23,24,27,30)/t12-/m0/s1
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n/an/a 7n/an/an/an/an/an/a



Parion Sciences Inc.

Curated by ChEMBL


Assay Description
Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assay

J Med Chem 49: 4098-115 (2006)


Article DOI: 10.1021/jm051134w
BindingDB Entry DOI: 10.7270/Q2FT8KNH
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(RAT)		BDBM50577701
PNG
(CHEMBL4868414)
Show SMILES [H][C@@]1(CCCC2=Cc3c(CC12)cnn3-c1ccc(C)cc1)[C@@](C)(O)c1cc(F)c(F)c(OC)c1 |r,t:5|
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n/an/a 7.90n/an/an/an/an/an/a


TBA

Assay Description
Agonist activity at glucocorticoid receptor in rat INS-1 832/13 cells transfected with CCL2-promoter luciferase plasmid construct assessed as reducti...

Citation and Details

Article DOI: 10.1021/acsmedchemlett.1c00379
BindingDB Entry DOI: 10.7270/Q2VM4H3N
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(RAT)		BDBM50577690
PNG
(CHEMBL4855992)
Show SMILES [H][C@@]1(CCCC2=Cc3c(C[C@]12C)cnn3-c1ccc(F)cc1)[C@](C)(O)c1ccccc1 |r,t:5|
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n/an/a 7.90n/an/an/an/an/an/a


TBA

Assay Description
Agonist activity at glucocorticoid receptor in rat INS-1 832/13 cells transfected with CCL2-promoter luciferase plasmid construct assessed as reducti...

Citation and Details

Article DOI: 10.1021/acsmedchemlett.1c00379
BindingDB Entry DOI: 10.7270/Q2VM4H3N
More data for this
Ligand-Target Pair
Amiloride-sensitive sodium channel subunit alpha


(Homo sapiens (Human))		BDBM50190462
PNG
(CHEMBL212432 | N-(3,5-diamino-6-chloropyrazine-2-c...)
Show SMILES NC(NC(=O)c1nc(Cl)c(N)nc1N)=NCCCCc1ccc(OCC(O)CO)cc1 |w:14.15|
Show InChI InChI=1S/C19H26ClN7O4/c20-15-17(22)26-16(21)14(25-15)18(30)27-19(23)24-8-2-1-3-11-4-6-13(7-5-11)31-10-12(29)9-28/h4-7,12,28-29H,1-3,8-10H2,(H4,21,22,26)(H3,23,24,27,30)
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n/an/a 8n/an/an/an/an/an/a



Parion Sciences Inc.

Curated by ChEMBL


Assay Description
Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assay

J Med Chem 49: 4098-115 (2006)


Article DOI: 10.1021/jm051134w
BindingDB Entry DOI: 10.7270/Q2FT8KNH
More data for this
Ligand-Target Pair
Amiloride-sensitive sodium channel subunit alpha


(Homo sapiens (Human))		BDBM50190486
PNG
(CHEMBL211161 | N-(3,5-diamino-6-chloropyrazine-2-c...)
Show SMILES NC(NC(=O)c1nc(Cl)c(N)nc1N)=NCCCCc1ccc(OCCO)cc1 |w:14.15|
Show InChI InChI=1S/C18H24ClN7O3/c19-14-16(21)25-15(20)13(24-14)17(28)26-18(22)23-8-2-1-3-11-4-6-12(7-5-11)29-10-9-27/h4-7,27H,1-3,8-10H2,(H4,20,21,25)(H3,22,23,26,28)
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n/an/a 9n/an/an/an/an/an/a



Parion Sciences Inc.

Curated by ChEMBL


Assay Description
Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assay

J Med Chem 49: 4098-115 (2006)


Article DOI: 10.1021/jm051134w
BindingDB Entry DOI: 10.7270/Q2FT8KNH
More data for this
Ligand-Target Pair
Amiloride-sensitive sodium channel subunit alpha


(Homo sapiens (Human))		BDBM50190494
PNG
(CHEMBL209303 | N-(3,5-diamino-6-chloropyrazine-2-c...)
Show SMILES NC(NC(=O)c1nc(Cl)c(N)nc1N)=NCCCCc1ccc(OC[C@H](O)CO)cc1 |w:14.15|
Show InChI InChI=1S/C19H26ClN7O4/c20-15-17(22)26-16(21)14(25-15)18(30)27-19(23)24-8-2-1-3-11-4-6-13(7-5-11)31-10-12(29)9-28/h4-7,12,28-29H,1-3,8-10H2,(H4,21,22,26)(H3,23,24,27,30)/t12-/m1/s1
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n/an/a 9n/an/an/an/an/an/a



Parion Sciences Inc.

Curated by ChEMBL


Assay Description
Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assay

J Med Chem 49: 4098-115 (2006)


Article DOI: 10.1021/jm051134w
BindingDB Entry DOI: 10.7270/Q2FT8KNH
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(RAT)		BDBM19192
PNG
((R)-[(4aR,5S)-1-(4-fluorophenyl)-4a-methyl-1H,4H,4...)
Show SMILES [H][C@@]1(CCCC2=Cc3c(C[C@]12C)cnn3-c1ccc(F)cc1)[C@@H](O)c1ccc(F)cc1 |r,t:5|
Show InChI InChI=1S/C25H24F2N2O/c1-25-14-17-15-28-29(21-11-9-20(27)10-12-21)23(17)13-18(25)3-2-4-22(25)24(30)16-5-7-19(26)8-6-16/h5-13,15,22,24,30H,2-4,14H2,1H3/t22-,24+,25+/m1/s1
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n/an/a 10n/an/an/an/an/an/a


TBA

Assay Description
Agonist activity at glucocorticoid receptor in rat INS-1 832/13 cells transfected with CCL2-promoter luciferase plasmid construct assessed as reducti...

Citation and Details

Article DOI: 10.1021/acsmedchemlett.1c00379
BindingDB Entry DOI: 10.7270/Q2VM4H3N
More data for this
Ligand-Target Pair
Amiloride-sensitive sodium channel subunit alpha


(Homo sapiens (Human))		BDBM50190481
PNG
(CHEMBL214239 | N-(3,5-diamino-6-chloropyrazine-2-c...)
Show SMILES NC(NC(=O)c1nc(Cl)c(N)nc1N)=NCCCCc1ccc(CO)cc1 |w:14.15|
Show InChI InChI=1S/C17H22ClN7O2/c18-13-15(20)24-14(19)12(23-13)16(27)25-17(21)22-8-2-1-3-10-4-6-11(9-26)7-5-10/h4-7,26H,1-3,8-9H2,(H4,19,20,24)(H3,21,22,25,27)
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n/an/a 14n/an/an/an/an/an/a



Parion Sciences Inc.

Curated by ChEMBL


Assay Description
Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assay

J Med Chem 49: 4098-115 (2006)


Article DOI: 10.1021/jm051134w
BindingDB Entry DOI: 10.7270/Q2FT8KNH
More data for this
Ligand-Target Pair
Amiloride-sensitive sodium channel subunit alpha


(Homo sapiens (Human))		BDBM50190459
PNG
(CHEMBL377986 | N-(3,5-diamino-6-chloropyrazine-2-c...)
Show SMILES COc1ccc(CCCCN=C(N)NC(=O)c2nc(Cl)c(N)nc2N)cc1 |w:10.9|
Show InChI InChI=1S/C17H22ClN7O2/c1-27-11-7-5-10(6-8-11)4-2-3-9-22-17(21)25-16(26)12-14(19)24-15(20)13(18)23-12/h5-8H,2-4,9H2,1H3,(H4,19,20,24)(H3,21,22,25,26)
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n/an/a 15n/an/an/an/an/an/a



Parion Sciences Inc.

Curated by ChEMBL


Assay Description
Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assay

J Med Chem 49: 4098-115 (2006)


Article DOI: 10.1021/jm051134w
BindingDB Entry DOI: 10.7270/Q2FT8KNH
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(RAT)		BDBM19199
PNG
((R)-[(4aR,5S)-1-(4-fluorophenyl)-4a-methyl-1H,4H,4...)
Show SMILES [H][C@@]1(CCCC2=Cc3c(C[C@]12C)cnn3-c1ccc(F)cc1)[C@@H](O)c1cc(F)c(F)c(OC)c1 |r,t:5|
Show InChI InChI=1S/C26H25F3N2O2/c1-26-13-16-14-30-31(19-8-6-18(27)7-9-19)22(16)12-17(26)4-3-5-20(26)25(32)15-10-21(28)24(29)23(11-15)33-2/h6-12,14,20,25,32H,3-5,13H2,1-2H3/t20-,25+,26+/m1/s1
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n/an/a 16n/an/an/an/an/an/a


TBA

Assay Description
Agonist activity at glucocorticoid receptor in rat INS-1 832/13 cells transfected with CCL2-promoter luciferase plasmid construct assessed as reducti...

Citation and Details

Article DOI: 10.1021/acsmedchemlett.1c00379
BindingDB Entry DOI: 10.7270/Q2VM4H3N
More data for this
Ligand-Target Pair
Amiloride-sensitive sodium channel subunit alpha


(Homo sapiens (Human))		BDBM50190468
PNG
(CHEMBL211600 | N-(3,5-diamino-6-chloropyrazine-2-c...)
Show SMILES NC(NC(=O)c1nc(Cl)c(N)nc1N)=NCCCCc1cccc(OCCO)c1 |w:14.15|
Show InChI InChI=1S/C18H24ClN7O3/c19-14-16(21)25-15(20)13(24-14)17(28)26-18(22)23-7-2-1-4-11-5-3-6-12(10-11)29-9-8-27/h3,5-6,10,27H,1-2,4,7-9H2,(H4,20,21,25)(H3,22,23,26,28)
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n/an/a 17n/an/an/an/an/an/a



Parion Sciences Inc.

Curated by ChEMBL


Assay Description
Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assay

J Med Chem 49: 4098-115 (2006)


Article DOI: 10.1021/jm051134w
BindingDB Entry DOI: 10.7270/Q2FT8KNH
More data for this
Ligand-Target Pair
Amiloride-sensitive sodium channel subunit alpha


(Homo sapiens (Human))		BDBM50190484
PNG
(CHEMBL210876 | N-(3,5-diamino-6-chloropyrazine-2-c...)
Show SMILES NC(NC(=O)c1nc(Cl)c(N)nc1N)=NCCCCc1ccc(O)cc1 |w:14.15|
Show InChI InChI=1S/C16H20ClN7O2/c17-12-14(19)23-13(18)11(22-12)15(26)24-16(20)21-8-2-1-3-9-4-6-10(25)7-5-9/h4-7,25H,1-3,8H2,(H4,18,19,23)(H3,20,21,24,26)
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n/an/a 17n/an/an/an/an/an/a



Parion Sciences Inc.

Curated by ChEMBL


Assay Description
Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assay

J Med Chem 49: 4098-115 (2006)


Article DOI: 10.1021/jm051134w
BindingDB Entry DOI: 10.7270/Q2FT8KNH
More data for this
Ligand-Target Pair
Amiloride-sensitive sodium channel subunit alpha


(Homo sapiens (Human))		BDBM50190489
PNG
((4-{4-[N-(3,5-diamino-6-chloropyrazine-2-carbonyl)...)
Show SMILES NC(NC(=O)c1nc(Cl)c(N)nc1N)=NCCCCc1ccc(OCCC(O)=O)cc1 |w:14.15|
Show InChI InChI=1S/C19H24ClN7O4/c20-15-17(22)26-16(21)14(25-15)18(30)27-19(23)24-9-2-1-3-11-4-6-12(7-5-11)31-10-8-13(28)29/h4-7H,1-3,8-10H2,(H,28,29)(H4,21,22,26)(H3,23,24,27,30)
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n/an/a 20n/an/an/an/an/an/a



Parion Sciences Inc.

Curated by ChEMBL


Assay Description
Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assay

J Med Chem 49: 4098-115 (2006)


Article DOI: 10.1021/jm051134w
BindingDB Entry DOI: 10.7270/Q2FT8KNH
More data for this
Ligand-Target Pair
Amiloride-sensitive sodium channel subunit alpha


(Homo sapiens (Human))		BDBM50190475
PNG
(CHEMBL380011 | N-(3,5-diamino-6-chloropyrazine-2-c...)
Show SMILES NC(NC(=O)c1nc(Cl)c(N)nc1N)=NCCCCc1cccc(O)c1 |w:14.15|
Show InChI InChI=1S/C16H20ClN7O2/c17-12-14(19)23-13(18)11(22-12)15(26)24-16(20)21-7-2-1-4-9-5-3-6-10(25)8-9/h3,5-6,8,25H,1-2,4,7H2,(H4,18,19,23)(H3,20,21,24,26)
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n/an/a 20n/an/an/an/an/an/a



Parion Sciences Inc.

Curated by ChEMBL


Assay Description
Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assay

J Med Chem 49: 4098-115 (2006)


Article DOI: 10.1021/jm051134w
BindingDB Entry DOI: 10.7270/Q2FT8KNH
More data for this
Ligand-Target Pair
Amiloride-sensitive sodium channel subunit alpha


(Homo sapiens (Human))		BDBM50190458
PNG
(CHEMBL386222 | sulfuric acid mono-(4-{4-[N-(3,5-di...)
Show SMILES NC(NC(=O)c1nc(Cl)c(N)nc1N)=NCCCCc1ccc(cc1)S(O)(=O)=O |w:14.15|
Show InChI InChI=1S/C16H20ClN7O4S/c17-12-14(19)23-13(18)11(22-12)15(25)24-16(20)21-8-2-1-3-9-4-6-10(7-5-9)29(26,27)28/h4-7H,1-3,8H2,(H4,18,19,23)(H,26,27,28)(H3,20,21,24,25)
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n/an/a 21n/an/an/an/an/an/a



Parion Sciences Inc.

Curated by ChEMBL


Assay Description
Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assay

J Med Chem 49: 4098-115 (2006)


Article DOI: 10.1021/jm051134w
BindingDB Entry DOI: 10.7270/Q2FT8KNH
More data for this
Ligand-Target Pair
Amiloride-sensitive sodium channel subunit alpha


(Homo sapiens (Human))		BDBM50190465
PNG
(1-(4-(4-aminophenyl)butyl)-3-(3,5-diamino-2-chloro...)
Show SMILES NC(NC(=O)c1nc(Cl)c(N)nc1N)=NCCCCc1ccc(N)cc1 |w:14.15|
Show InChI InChI=1S/C16H21ClN8O/c17-12-14(20)24-13(19)11(23-12)15(26)25-16(21)22-8-2-1-3-9-4-6-10(18)7-5-9/h4-7H,1-3,8,18H2,(H4,19,20,24)(H3,21,22,25,26)
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n/an/a 21n/an/an/an/an/an/a



Parion Sciences Inc.

Curated by ChEMBL


Assay Description
Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assay

J Med Chem 49: 4098-115 (2006)


Article DOI: 10.1021/jm051134w
BindingDB Entry DOI: 10.7270/Q2FT8KNH
More data for this
Ligand-Target Pair
Amiloride-sensitive sodium channel subunit alpha


(Homo sapiens (Human))		BDBM50190488
PNG
(4-{4-[N'-(3,5-diamino-6-chloropyrazine-2-carbonyl)...)
Show SMILES COC(=O)c1ccc(CCCCN=C(N)NC(=O)c2nc(Cl)c(N)nc2N)cc1 |w:12.11|
Show InChI InChI=1S/C18H22ClN7O3/c1-29-17(28)11-7-5-10(6-8-11)4-2-3-9-23-18(22)26-16(27)12-14(20)25-15(21)13(19)24-12/h5-8H,2-4,9H2,1H3,(H4,20,21,25)(H3,22,23,26,27)
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n/an/a 22n/an/an/an/an/an/a



Parion Sciences Inc.

Curated by ChEMBL


Assay Description
Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assay

J Med Chem 49: 4098-115 (2006)


Article DOI: 10.1021/jm051134w
BindingDB Entry DOI: 10.7270/Q2FT8KNH
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 11


(Homo sapiens (Human))		BDBM50361467
PNG
(CHEMBL1938400)
Show SMILES CC(C)(C)c1cc(NC(=O)NCc2ccccc2Sc2ccc3nnc(-c4ccccc4SCCO)n3c2)n(n1)-c1ccc(O)c(Cl)c1
Show InChI InChI=1S/C35H34ClN7O3S2/c1-35(2,3)30-19-32(43(41-30)23-12-14-27(45)26(36)18-23)38-34(46)37-20-22-8-4-6-10-28(22)48-24-13-15-31-39-40-33(42(31)21-24)25-9-5-7-11-29(25)47-17-16-44/h4-15,18-19,21,44-45H,16-17,20H2,1-3H3,(H2,37,38,46)
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n/an/a 23n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of p38beta MAPK

J Med Chem 54: 7797-814 (2011)


Article DOI: 10.1021/jm200677b
BindingDB Entry DOI: 10.7270/Q2HX1D4Q
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(RAT)		BDBM13775
PNG
((1S,2R,10S,11S,14R,15S,17S)-14,17-dihydroxy-14-(2-...)
Show SMILES [H][C@@]12CC[C@](O)(C(=O)CO)[C@@]1(C)C[C@H](O)[C@@]1([H])[C@@]2([H])CCC2=CC(=O)CC[C@]12C |t:23|
Show InChI InChI=1S/C21H30O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-16,18,22,24,26H,3-8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1
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n/an/a 25n/an/an/an/an/an/a


TBA

Assay Description
Agonist activity at glucocorticoid receptor in rat INS-1 832/13 cells transfected with CCL2-promoter luciferase plasmid construct assessed as reducti...

Citation and Details

Article DOI: 10.1021/acsmedchemlett.1c00379
BindingDB Entry DOI: 10.7270/Q2VM4H3N
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Amiloride-sensitive sodium channel subunit alpha


(Homo sapiens (Human))		BDBM50190480
PNG
(CHEMBL214220 | N-(3,5-diamino-6-chloropyrazine-2-c...)
Show SMILES COc1ccc(OCCCN=C(N)NC(=O)c2nc(Cl)c(N)nc2N)cc1 |w:10.9|
Show InChI InChI=1S/C16H20ClN7O3/c1-26-9-3-5-10(6-4-9)27-8-2-7-21-16(20)24-15(25)11-13(18)23-14(19)12(17)22-11/h3-6H,2,7-8H2,1H3,(H4,18,19,23)(H3,20,21,24,25)
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n/an/a 25n/an/an/an/an/an/a



Parion Sciences Inc.

Curated by ChEMBL


Assay Description
Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assay

J Med Chem 49: 4098-115 (2006)


Article DOI: 10.1021/jm051134w
BindingDB Entry DOI: 10.7270/Q2FT8KNH
More data for this
Ligand-Target Pair
Amiloride-sensitive sodium channel subunit alpha


(Homo sapiens (Human))		BDBM50190490
PNG
(CHEMBL212534 | N-(3,5-diamino-6-chloropyrazine-2-c...)
Show SMILES NC(NC(=O)c1nc(Cl)c(N)nc1N)=NCCCCc1cccc(OCC(O)CO)c1 |w:14.15|
Show InChI InChI=1S/C19H26ClN7O4/c20-15-17(22)26-16(21)14(25-15)18(30)27-19(23)24-7-2-1-4-11-5-3-6-13(8-11)31-10-12(29)9-28/h3,5-6,8,12,28-29H,1-2,4,7,9-10H2,(H4,21,22,26)(H3,23,24,27,30)
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n/an/a 26n/an/an/an/an/an/a



Parion Sciences Inc.

Curated by ChEMBL


Assay Description
Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assay

J Med Chem 49: 4098-115 (2006)


Article DOI: 10.1021/jm051134w
BindingDB Entry DOI: 10.7270/Q2FT8KNH
More data for this
Ligand-Target Pair
Amiloride-sensitive sodium channel subunit alpha


(Homo sapiens (Human))		BDBM50190493
PNG
(CHEMBL211658 | N-(3,5-diamino-6-chloropyrazine-2-c...)
Show SMILES NC(NC(=O)c1nc(Cl)c(N)nc1N)=NCCCCc1ccccc1OCC(O)CO |w:14.15|
Show InChI InChI=1S/C19H26ClN7O4/c20-15-17(22)26-16(21)14(25-15)18(30)27-19(23)24-8-4-3-6-11-5-1-2-7-13(11)31-10-12(29)9-28/h1-2,5,7,12,28-29H,3-4,6,8-10H2,(H4,21,22,26)(H3,23,24,27,30)
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n/an/a 28n/an/an/an/an/an/a



Parion Sciences Inc.

Curated by ChEMBL


Assay Description
Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assay

J Med Chem 49: 4098-115 (2006)


Article DOI: 10.1021/jm051134w
BindingDB Entry DOI: 10.7270/Q2FT8KNH
More data for this
Ligand-Target Pair
Amiloride-sensitive sodium channel subunit alpha


(Homo sapiens (Human))		BDBM50190456
PNG
(CHEMBL209659 | N-(3,5-diamino-6-chloropyrazine-2-c...)
Show SMILES NC(NC(=O)c1nc(Cl)c(N)nc1N)=NCCCCc1ccccc1 |w:14.15|
Show InChI InChI=1S/C16H20ClN7O/c17-12-14(19)23-13(18)11(22-12)15(25)24-16(20)21-9-5-4-8-10-6-2-1-3-7-10/h1-3,6-7H,4-5,8-9H2,(H4,18,19,23)(H3,20,21,24,25)
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n/an/a 29n/an/an/an/an/an/a



Parion Sciences Inc.

Curated by ChEMBL


Assay Description
Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assay

J Med Chem 49: 4098-115 (2006)


Article DOI: 10.1021/jm051134w
BindingDB Entry DOI: 10.7270/Q2FT8KNH
More data for this
Ligand-Target Pair
Amiloride-sensitive sodium channel subunit alpha


(Homo sapiens (Human))		BDBM50190471
PNG
(CHEMBL379066 | N-(3,5-diamino-6-chloropyrazine-2-c...)
Show SMILES NC(NC(=O)c1nc(Cl)c(N)nc1N)=NCCCCc1ccccc1O |w:14.15|
Show InChI InChI=1S/C16H20ClN7O2/c17-12-14(19)23-13(18)11(22-12)15(26)24-16(20)21-8-4-3-6-9-5-1-2-7-10(9)25/h1-2,5,7,25H,3-4,6,8H2,(H4,18,19,23)(H3,20,21,24,26)
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n/an/a 30n/an/an/an/an/an/a



Parion Sciences Inc.

Curated by ChEMBL


Assay Description
Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assay

J Med Chem 49: 4098-115 (2006)


Article DOI: 10.1021/jm051134w
BindingDB Entry DOI: 10.7270/Q2FT8KNH
More data for this
Ligand-Target Pair
Amiloride-sensitive sodium channel subunit alpha


(Homo sapiens (Human))		BDBM50190455
PNG
(CHEMBL208889 | N-(3,5-diamino-6-chloropyrazine-2-c...)
Show SMILES NC(NC(=O)c1nc(Cl)c(N)nc1N)=NCCCCc1ccccc1OCCO |w:14.15|
Show InChI InChI=1S/C18H24ClN7O3/c19-14-16(21)25-15(20)13(24-14)17(28)26-18(22)23-8-4-3-6-11-5-1-2-7-12(11)29-10-9-27/h1-2,5,7,27H,3-4,6,8-10H2,(H4,20,21,25)(H3,22,23,26,28)
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n/an/a 31n/an/an/an/an/an/a



Parion Sciences Inc.

Curated by ChEMBL


Assay Description
Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assay

J Med Chem 49: 4098-115 (2006)


Article DOI: 10.1021/jm051134w
BindingDB Entry DOI: 10.7270/Q2FT8KNH
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(RAT)		BDBM50577697
PNG
(CHEMBL4846557)
Show SMILES [H][C@@]1(CCCC2=Cc3c(C[C@]12C)cnn3-c1ccc(C)cc1)[C@@](C)(O)c1ccccc1 |r,t:5|
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n/an/a 32n/an/an/an/an/an/a


TBA

Assay Description
Agonist activity at glucocorticoid receptor in rat INS-1 832/13 cells transfected with CCL2-promoter luciferase plasmid construct assessed as reducti...

Citation and Details

Article DOI: 10.1021/acsmedchemlett.1c00379
BindingDB Entry DOI: 10.7270/Q2VM4H3N
More data for this
Ligand-Target Pair
Amiloride-sensitive sodium channel subunit alpha


(Homo sapiens (Human))		BDBM50190478
PNG
(CHEMBL211946 | N-(3,5-diamino-6-chloropyrazine-2-c...)
Show SMILES NC(NC(=O)c1nc(Cl)c(N)nc1N)=NCCCOc1ccc(O)cc1 |w:14.15|
Show InChI InChI=1S/C15H18ClN7O3/c16-11-13(18)22-12(17)10(21-11)14(25)23-15(19)20-6-1-7-26-9-4-2-8(24)3-5-9/h2-5,24H,1,6-7H2,(H4,17,18,22)(H3,19,20,23,25)
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n/an/a 32n/an/an/an/an/an/a



Parion Sciences Inc.

Curated by ChEMBL


Assay Description
Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assay

J Med Chem 49: 4098-115 (2006)


Article DOI: 10.1021/jm051134w
BindingDB Entry DOI: 10.7270/Q2FT8KNH
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(RAT)		BDBM19204
PNG
(2-[(4aR,5S)-1-(4-fluorophenyl)-4a-methyl-1H,4H,4aH...)
Show SMILES [H][C@@]1(CCCC2=Cc3c(C[C@]12C)cnn3-c1ccc(F)cc1)C(C)(C)O |r,t:5|
Show InChI InChI=1S/C21H25FN2O/c1-20(2,25)19-6-4-5-15-11-18-14(12-21(15,19)3)13-23-24(18)17-9-7-16(22)8-10-17/h7-11,13,19,25H,4-6,12H2,1-3H3/t19-,21+/m1/s1
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n/an/a 40n/an/an/an/an/an/a


TBA

Assay Description
Agonist activity at glucocorticoid receptor in rat INS-1 832/13 cells transfected with CCL2-promoter luciferase plasmid construct assessed as reducti...

Citation and Details

Article DOI: 10.1021/acsmedchemlett.1c00379
BindingDB Entry DOI: 10.7270/Q2VM4H3N
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(RAT)		BDBM50577702
PNG
(CHEMBL4875267)
Show SMILES [H][C@@]1(CCCC2=Cc3c(C[C@]12C)cnn3-c1ccc(C)cc1)[C@@H](O)c1ccsc1 |r,t:5|
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n/an/a 40n/an/an/an/an/an/a


TBA

Assay Description
Agonist activity at glucocorticoid receptor in rat INS-1 832/13 cells transfected with CCL2-promoter luciferase plasmid construct assessed as reducti...

Citation and Details

Article DOI: 10.1021/acsmedchemlett.1c00379
BindingDB Entry DOI: 10.7270/Q2VM4H3N
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(RAT)		BDBM19191
PNG
((R)-[(4aR,5S)-1-(4-fluorophenyl)-4a-methyl-1H,4H,4...)
Show SMILES [H][C@@]1(CCCC2=Cc3c(C[C@]12C)cnn3-c1ccc(F)cc1)[C@@H](O)c1ccccc1 |r,t:5|
Show InChI InChI=1S/C25H25FN2O/c1-25-15-18-16-27-28(21-12-10-20(26)11-13-21)23(18)14-19(25)8-5-9-22(25)24(29)17-6-3-2-4-7-17/h2-4,6-7,10-14,16,22,24,29H,5,8-9,15H2,1H3/t22-,24+,25+/m1/s1
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n/an/a 40n/an/an/an/an/an/a


TBA

Assay Description
Agonist activity at glucocorticoid receptor in rat INS-1 832/13 cells transfected with CCL2-promoter luciferase plasmid construct assessed as reducti...

Citation and Details

Article DOI: 10.1021/acsmedchemlett.1c00379
BindingDB Entry DOI: 10.7270/Q2VM4H3N
More data for this
Ligand-Target Pair
Amiloride-sensitive sodium channel subunit alpha


(Homo sapiens (Human))		BDBM50190460
PNG
(CHEMBL211773 | N-(3,5-diamino-6-chloropyrazine-2-c...)
Show SMILES COc1ccc(COCCN=C(N)NC(=O)c2nc(Cl)c(N)nc2N)cc1 |w:10.9|
Show InChI InChI=1S/C16H20ClN7O3/c1-26-10-4-2-9(3-5-10)8-27-7-6-21-16(20)24-15(25)11-13(18)23-14(19)12(17)22-11/h2-5H,6-8H2,1H3,(H4,18,19,23)(H3,20,21,24,25)
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n/an/a 41n/an/an/an/an/an/a



Parion Sciences Inc.

Curated by ChEMBL


Assay Description
Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assay

J Med Chem 49: 4098-115 (2006)


Article DOI: 10.1021/jm051134w
BindingDB Entry DOI: 10.7270/Q2FT8KNH
More data for this
Ligand-Target Pair
Amiloride-sensitive sodium channel subunit alpha


(Homo sapiens (Human))		BDBM50190457
PNG
(CHEMBL211072 | N-(3,5-diamino-6-chloropyrazine-2-c...)
Show SMILES NC(NC(=O)c1nc(Cl)c(N)nc1N)=NCCCCc1ccc(O)c(O)c1 |w:14.15|
Show InChI InChI=1S/C16H20ClN7O3/c17-12-14(19)23-13(18)11(22-12)15(27)24-16(20)21-6-2-1-3-8-4-5-9(25)10(26)7-8/h4-5,7,25-26H,1-3,6H2,(H4,18,19,23)(H3,20,21,24,27)
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n/an/a 42n/an/an/an/an/an/a



Parion Sciences Inc.

Curated by ChEMBL


Assay Description
Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assay

J Med Chem 49: 4098-115 (2006)


Article DOI: 10.1021/jm051134w
BindingDB Entry DOI: 10.7270/Q2FT8KNH
More data for this
Ligand-Target Pair
Amiloride-sensitive sodium channel subunit alpha


(Homo sapiens (Human))		BDBM50190483
PNG
((4-{4-[N-(3,5-diamino-6-chloropyrazine-2-carbonyl)...)
Show SMILES NC(NC(=O)c1nc(Cl)c(N)nc1N)=NCCCCc1ccc(OCC(O)=O)cc1 |w:14.15|
Show InChI InChI=1S/C18H22ClN7O4/c19-14-16(21)25-15(20)13(24-14)17(29)26-18(22)23-8-2-1-3-10-4-6-11(7-5-10)30-9-12(27)28/h4-7H,1-3,8-9H2,(H,27,28)(H4,20,21,25)(H3,22,23,26,29)
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n/an/a 48n/an/an/an/an/an/a



Parion Sciences Inc.

Curated by ChEMBL


Assay Description
Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assay

J Med Chem 49: 4098-115 (2006)


Article DOI: 10.1021/jm051134w
BindingDB Entry DOI: 10.7270/Q2FT8KNH
More data for this
Ligand-Target Pair
Amiloride-sensitive sodium channel subunit alpha


(Homo sapiens (Human))		BDBM50190479
PNG
(CHEMBL211664 | N-(3,5-diamino-6-chloropyrazine-2-c...)
Show SMILES NC(NC(=O)c1nc(Cl)c(N)nc1N)=NCCCc1ccccc1 |w:14.15|
Show InChI InChI=1S/C15H18ClN7O/c16-11-13(18)22-12(17)10(21-11)14(24)23-15(19)20-8-4-7-9-5-2-1-3-6-9/h1-3,5-6H,4,7-8H2,(H4,17,18,22)(H3,19,20,23,24)
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n/an/a 50n/an/an/an/an/an/a



Parion Sciences Inc.

Curated by ChEMBL


Assay Description
Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assay

J Med Chem 49: 4098-115 (2006)


Article DOI: 10.1021/jm051134w
BindingDB Entry DOI: 10.7270/Q2FT8KNH
More data for this
Ligand-Target Pair
Amiloride-sensitive sodium channel subunit alpha


(Homo sapiens (Human))		BDBM50190477
PNG
(4-{4-[N'-(3,5-diamino-6-chloropyrazine-2-carbonyl)...)
Show SMILES NC(NC(=O)c1nc(Cl)c(N)nc1N)=NCCCCc1ccc(cc1)C(O)=O |w:14.15|
Show InChI InChI=1S/C17H20ClN7O3/c18-12-14(20)24-13(19)11(23-12)15(26)25-17(21)22-8-2-1-3-9-4-6-10(7-5-9)16(27)28/h4-7H,1-3,8H2,(H,27,28)(H4,19,20,24)(H3,21,22,25,26)
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n/an/a 51n/an/an/an/an/an/a



Parion Sciences Inc.

Curated by ChEMBL


Assay Description
Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assay

J Med Chem 49: 4098-115 (2006)


Article DOI: 10.1021/jm051134w
BindingDB Entry DOI: 10.7270/Q2FT8KNH
More data for this
Ligand-Target Pair
Amiloride-sensitive sodium channel subunit alpha


(Homo sapiens (Human))		BDBM50190461
PNG
(CHEMBL208620 | N-(3,5-diamino-6-chloropyrazine-2-c...)
Show SMILES NC(NC(=O)c1nc(Cl)c(N)nc1N)=NCCCCCCc1ccccc1 |w:14.15|
Show InChI InChI=1S/C18H24ClN7O/c19-14-16(21)25-15(20)13(24-14)17(27)26-18(22)23-11-7-2-1-4-8-12-9-5-3-6-10-12/h3,5-6,9-10H,1-2,4,7-8,11H2,(H4,20,21,25)(H3,22,23,26,27)
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n/an/a 58n/an/an/an/an/an/a



Parion Sciences Inc.

Curated by ChEMBL


Assay Description
Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assay

J Med Chem 49: 4098-115 (2006)


Article DOI: 10.1021/jm051134w
BindingDB Entry DOI: 10.7270/Q2FT8KNH
More data for this
Ligand-Target Pair
Amiloride-sensitive sodium channel subunit alpha


(Homo sapiens (Human))		BDBM50190463
PNG
(CHEMBL209977 | N-(3,5-diamino-6-chloropyrazine-2-c...)
Show SMILES NC(NC(=O)c1nc(Cl)c(N)nc1N)=NCCc1ccc(O)cc1 |w:14.15|
Show InChI InChI=1S/C14H16ClN7O2/c15-10-12(17)21-11(16)9(20-10)13(24)22-14(18)19-6-5-7-1-3-8(23)4-2-7/h1-4,23H,5-6H2,(H4,16,17,21)(H3,18,19,22,24)
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n/an/a 62n/an/an/an/an/an/a



Parion Sciences Inc.

Curated by ChEMBL


Assay Description
Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assay

J Med Chem 49: 4098-115 (2006)


Article DOI: 10.1021/jm051134w
BindingDB Entry DOI: 10.7270/Q2FT8KNH
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(RAT)		BDBM50577695
PNG
(CHEMBL4853394)
Show SMILES [H][C@@]1(CCCC2=Cc3c(C[C@]12C)cnn3-c1ccc(C)cc1)C(C)(C)O |r,t:5|
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n/an/a 63n/an/an/an/an/an/a


TBA

Assay Description
Agonist activity at glucocorticoid receptor in rat INS-1 832/13 cells transfected with CCL2-promoter luciferase plasmid construct assessed as reducti...

Citation and Details

Article DOI: 10.1021/acsmedchemlett.1c00379
BindingDB Entry DOI: 10.7270/Q2VM4H3N
More data for this
Ligand-Target Pair
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