Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
N-lysine methyltransferase SMYD2 (Homo sapiens (Human)) | BDBM50180955 (CHEMBL3818617) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 8 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
BAYER Pharma AG Curated by ChEMBL | Assay Description Competitive inhibition of full length 6xHis-tagged SMYD2 (unknown origin) expressed in Escherichia coli using varying levels of Btn-Ahx-GSRAHSSHLKSKK... | J Med Chem 59: 4578-600 (2016) Article DOI: 10.1021/acs.jmedchem.5b01890 BindingDB Entry DOI: 10.7270/Q2RN39S5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostaglandin F2-alpha receptor (Homo sapiens (Human)) | BDBM520995 ((+)-5-[({6-Bromo-3-methyl-2-[(2H8)pyrrolidin-1-yl]...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | 16 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Displacement of [3H]PGF2alpha from full-length recombinant human FP receptor expressed in HEK293 cell membranes measured after 60 mins by scintillati... | Citation and Details Article DOI: 10.1021/acs.jmedchem.0c00834 BindingDB Entry DOI: 10.7270/Q2FJ2MC9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
N-lysine methyltransferase SMYD2 (Homo sapiens (Human)) | BDBM50180955 (CHEMBL3818617) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 28 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
BAYER Pharma AG Curated by ChEMBL | Assay Description Uncompetitive inhibition of full length 6xHis-tagged SMYD2 (unknown origin) expressed in Escherichia coli using fixed levels of Btn-Ahx-GSRAHSSHLKSKK... | J Med Chem 59: 4578-600 (2016) Article DOI: 10.1021/acs.jmedchem.5b01890 BindingDB Entry DOI: 10.7270/Q2RN39S5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human)) | BDBM470573 (US10815215, Example 233 | US11130745, Example 233 ...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller et al., 19... | Citation and Details BindingDB Entry DOI: 10.7270/Q20C4ZXM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Peroxisome proliferator-activated receptor gamma (Mus musculus) | BDBM50591456 (CHEMBL5207130) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | 0.140 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Citation and Details Article DOI: 10.1021/acs.jmedchem.2c01379 BindingDB Entry DOI: 10.7270/Q2W099XX | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Peroxisome proliferator-activated receptor gamma (Homo sapiens (Human)) | BDBM50591460 (CHEMBL5191837) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 0.160 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Citation and Details Article DOI: 10.1021/acs.jmedchem.2c01379 BindingDB Entry DOI: 10.7270/Q2W099XX | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Peroxisome proliferator-activated receptor gamma (Homo sapiens (Human)) | BDBM50591456 (CHEMBL5207130) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | 0.170 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Citation and Details Article DOI: 10.1021/acs.jmedchem.2c01379 BindingDB Entry DOI: 10.7270/Q2W099XX | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Peroxisome proliferator-activated receptor gamma (Homo sapiens (Human)) | BDBM50591479 (CHEMBL5187164) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | 0.220 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Citation and Details Article DOI: 10.1021/acs.jmedchem.2c01379 BindingDB Entry DOI: 10.7270/Q2W099XX | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Peroxisome proliferator-activated receptor gamma (Homo sapiens (Human)) | BDBM50591459 (CHEMBL5179281) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 0.230 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Citation and Details Article DOI: 10.1021/acs.jmedchem.2c01379 BindingDB Entry DOI: 10.7270/Q2W099XX | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Peroxisome proliferator-activated receptor gamma (Homo sapiens (Human)) | BDBM50591461 (CHEMBL5206512) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 0.25 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Citation and Details Article DOI: 10.1021/acs.jmedchem.2c01379 BindingDB Entry DOI: 10.7270/Q2W099XX | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Peroxisome proliferator-activated receptor gamma (Homo sapiens (Human)) | BDBM50591480 (CHEMBL5207464) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 0.290 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Citation and Details Article DOI: 10.1021/acs.jmedchem.2c01379 BindingDB Entry DOI: 10.7270/Q2W099XX | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Peroxisome proliferator-activated receptor gamma (Homo sapiens (Human)) | BDBM50591466 (CHEMBL5204936) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 0.320 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Citation and Details Article DOI: 10.1021/acs.jmedchem.2c01379 BindingDB Entry DOI: 10.7270/Q2W099XX | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Peroxisome proliferator-activated receptor gamma (Homo sapiens (Human)) | BDBM50591456 (CHEMBL5207130) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Citation and Details Article DOI: 10.1021/acs.jmedchem.2c01379 BindingDB Entry DOI: 10.7270/Q2W099XX | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostaglandin F2-alpha receptor (Homo sapiens (Human)) | BDBM520924 (US11149018, Example 205) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.410 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS... | Citation and Details BindingDB Entry DOI: 10.7270/Q25X2D3J | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostaglandin F2-alpha receptor (Homo sapiens (Human)) | BDBM520771 (US11149018, Example 58) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.520 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS... | Citation and Details BindingDB Entry DOI: 10.7270/Q25X2D3J | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostaglandin F2-alpha receptor (Homo sapiens (Human)) | BDBM520770 ((+/−)-5-[({6-Bromo-2-[3-ethylpiperidin-1-yl]...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 0.530 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Antagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins fo... | Citation and Details Article DOI: 10.1021/acs.jmedchem.0c00834 BindingDB Entry DOI: 10.7270/Q2FJ2MC9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostaglandin F2-alpha receptor (Homo sapiens (Human)) | BDBM520770 ((+/−)-5-[({6-Bromo-2-[3-ethylpiperidin-1-yl]...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 0.530 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Antagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins fo... | Citation and Details Article DOI: 10.1021/acs.jmedchem.0c00834 BindingDB Entry DOI: 10.7270/Q2FJ2MC9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Peroxisome proliferator-activated receptor gamma (Homo sapiens (Human)) | BDBM50591465 (CHEMBL5201278) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 0.580 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Citation and Details Article DOI: 10.1021/acs.jmedchem.2c01379 BindingDB Entry DOI: 10.7270/Q2W099XX | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostaglandin F2-alpha receptor (Homo sapiens (Human)) | BDBM520911 (US11149018, Example 193) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.620 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS... | Citation and Details BindingDB Entry DOI: 10.7270/Q25X2D3J | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostaglandin F2-alpha receptor (Homo sapiens (Human)) | BDBM520868 (US11149018, Example 152) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.630 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS... | Citation and Details BindingDB Entry DOI: 10.7270/Q25X2D3J | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostaglandin F2-alpha receptor (Homo sapiens (Human)) | BDBM520929 (US11149018, Example 210) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.680 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS... | Citation and Details BindingDB Entry DOI: 10.7270/Q25X2D3J | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostaglandin F2-alpha receptor (Homo sapiens (Human)) | BDBM520869 (US11149018, Example 153 | US11149018, Example 274) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.730 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS... | Citation and Details BindingDB Entry DOI: 10.7270/Q25X2D3J | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostaglandin F2-alpha receptor (Homo sapiens (Human)) | BDBM520939 (US11149018, Example 220) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.760 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS... | Citation and Details BindingDB Entry DOI: 10.7270/Q25X2D3J | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostaglandin F2-alpha receptor (Homo sapiens (Human)) | BDBM520843 (US11149018, Example 127) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.790 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS... | Citation and Details BindingDB Entry DOI: 10.7270/Q25X2D3J | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostaglandin F2-alpha receptor (Homo sapiens (Human)) | BDBM520770 ((+/−)-5-[({6-Bromo-2-[3-ethylpiperidin-1-yl]...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 0.830 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Antagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins fo... | Citation and Details Article DOI: 10.1021/acs.jmedchem.0c00834 BindingDB Entry DOI: 10.7270/Q2FJ2MC9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostaglandin F2-alpha receptor (Homo sapiens (Human)) | BDBM520774 (US11149018, Example 61) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.830 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS... | Citation and Details BindingDB Entry DOI: 10.7270/Q25X2D3J | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostaglandin F2-alpha receptor (Homo sapiens (Human)) | BDBM520770 ((+/−)-5-[({6-Bromo-2-[3-ethylpiperidin-1-yl]...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.840 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS... | Citation and Details BindingDB Entry DOI: 10.7270/Q25X2D3J | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostaglandin F2-alpha receptor (Homo sapiens (Human)) | BDBM520844 (US11149018, Example 128 | US11149018, Example 272) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.850 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS... | Citation and Details BindingDB Entry DOI: 10.7270/Q25X2D3J | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
72 kDa type IV collagenase (Homo sapiens (Human)) | BDBM50063139 ((R)-2-[4-(4-Bromo-benzoylamino)-benzenesulfonylami...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 0.900 | n/a | n/a | n/a | n/a | n/a | n/a |
ETH Zurich Curated by ChEMBL | Assay Description Inhibition of human full length MMP2 using Mca-Pro-Leu-Gly-Leu-Dpa(Dnp)-Ala-Arg-NH2 as substrate measured up to 120 mins by fluorescence assay | J Med Chem 56: 4912-20 (2013) Article DOI: 10.1021/jm400156p BindingDB Entry DOI: 10.7270/Q2959MHQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostaglandin F2-alpha receptor (Homo sapiens (Human)) | BDBM523442 (US11136296, Example 173 | US11136296, Example 222 ...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.960 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS... | Citation and Details BindingDB Entry DOI: 10.7270/Q2NS0Z2X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
72 kDa type IV collagenase (Homo sapiens (Human)) | BDBM50491906 (CHEMBL2385442) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | <1 | n/a | n/a | n/a | n/a | n/a | n/a |
ETH Zurich Curated by ChEMBL | Assay Description Inhibition of human full length MMP2 using Mca-Pro-Leu-Gly-Leu-Dpa(Dnp)-Ala-Arg-NH2 as substrate measured up to 120 mins by fluorescence assay | J Med Chem 56: 4912-20 (2013) Article DOI: 10.1021/jm400156p BindingDB Entry DOI: 10.7270/Q2959MHQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostaglandin F2-alpha receptor (Homo sapiens (Human)) | BDBM50547366 (CHEMBL4761725) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | <1 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Displacement of [3H]PGF2alpha from full-length recombinant human FP receptor expressed in HEK293 cell membranes measured after 60 mins by scintillati... | Citation and Details Article DOI: 10.1021/acs.jmedchem.0c00834 BindingDB Entry DOI: 10.7270/Q2FJ2MC9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human)) | BDBM470561 (1-(4-[(2-chloro-6-fluorophenyl)carbamoyl]-2-fluoro...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details BindingDB Entry DOI: 10.7270/Q2HQ4414 | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human)) | BDBM470358 (4-(3-ethyl-4-methyl-5-oxo-4,5-dihydro-1H-1,2,4-tri...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details BindingDB Entry DOI: 10.7270/Q2HQ4414 | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human)) | BDBM470561 (1-(4-[(2-chloro-6-fluorophenyl)carbamoyl]-2-fluoro...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller et al., 19... | Citation and Details BindingDB Entry DOI: 10.7270/Q20C4ZXM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human)) | BDBM470358 (4-(3-ethyl-4-methyl-5-oxo-4,5-dihydro-1H-1,2,4-tri...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-Dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller et al., 19... | Citation and Details BindingDB Entry DOI: 10.7270/Q20C4ZXM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human)) | BDBM490338 (N-(2-chloro-6-fluorophenyl)-5-fluoro-4-(3-oxo-5,6,...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
BAYER AKTIENGESELLSCHAFT; BAYER PHARMA AKTIENGESELLSCHAFT; THE BROAD INSTITUTE, INC.; PRESIDENT AND FELLOWS OF HARVARD COLLEGE; THE GENERAL HOSPITAL CORPORATION US Patent | Assay Description Assay—1: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e... | US Patent US10968216 (2021) BindingDB Entry DOI: 10.7270/Q2WM1HJN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human)) | BDBM490402 (5-fluoro-N-(2-methylphenyl)-4-(3-oxo-5,6,7,8-tetra...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
BAYER AKTIENGESELLSCHAFT; BAYER PHARMA AKTIENGESELLSCHAFT; THE BROAD INSTITUTE, INC.; PRESIDENT AND FELLOWS OF HARVARD COLLEGE; THE GENERAL HOSPITAL CORPORATION US Patent | Assay Description Assay—2: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-Dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e... | US Patent US10968216 (2021) BindingDB Entry DOI: 10.7270/Q2WM1HJN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human)) | BDBM470561 (1-(4-[(2-chloro-6-fluorophenyl)carbamoyl]-2-fluoro...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
BAYER AKTIENGESELLSCHAFT; BAYER PHARMA AKTIENGELLSCHAFT; THE BROAD INSTITUTE, INC.; PRESIDENT AND FELLOWS OF HARVARD COLLEGE; THE GENERAL HOSPITAL CORPORATION US Patent | Assay Description Assay 1: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e... | US Patent US10815215 (2020) BindingDB Entry DOI: 10.7270/Q2RJ4NJH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human)) | BDBM490556 (5-fluoro-N-(2-methylphenyl)-4-(3-oxo-5,6,7,8-tetra...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
BAYER AKTIENGESELLSCHAFT; BAYER PHARMA AKTIENGESELLSCHAFT; THE BROAD INSTITUTE, INC.; PRESIDENT AND FELLOWS OF HARVARD COLLEGE; THE GENERAL HOSPITAL CORPORATION US Patent | Assay Description Assay—2: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-Dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e... | US Patent US10968216 (2021) BindingDB Entry DOI: 10.7270/Q2WM1HJN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human)) | BDBM470358 (4-(3-ethyl-4-methyl-5-oxo-4,5-dihydro-1H-1,2,4-tri...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
BAYER AKTIENGESELLSCHAFT; BAYER PHARMA AKTIENGELLSCHAFT; THE BROAD INSTITUTE, INC.; PRESIDENT AND FELLOWS OF HARVARD COLLEGE; THE GENERAL HOSPITAL CORPORATION US Patent | Assay Description Assay 2: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-Dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e... | US Patent US10815215 (2020) BindingDB Entry DOI: 10.7270/Q2RJ4NJH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
72 kDa type IV collagenase (Homo sapiens (Human)) | BDBM50491917 (CHEMBL2385444) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | <1 | n/a | n/a | n/a | n/a | n/a | n/a |
ETH Zurich Curated by ChEMBL | Assay Description Inhibition of human full length MMP2 using Mca-Pro-Leu-Gly-Leu-Dpa(Dnp)-Ala-Arg-NH2 as substrate measured up to 120 mins by fluorescence assay | J Med Chem 56: 4912-20 (2013) Article DOI: 10.1021/jm400156p BindingDB Entry DOI: 10.7270/Q2959MHQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
72 kDa type IV collagenase (Homo sapiens (Human)) | BDBM50491913 (CHEMBL2385443) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | <1 | n/a | n/a | n/a | n/a | n/a | n/a |
ETH Zurich Curated by ChEMBL | Assay Description Inhibition of human full length MMP2 using Mca-Pro-Leu-Gly-Leu-Dpa(Dnp)-Ala-Arg-NH2 as substrate measured up to 120 mins by fluorescence assay | J Med Chem 56: 4912-20 (2013) Article DOI: 10.1021/jm400156p BindingDB Entry DOI: 10.7270/Q2959MHQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
72 kDa type IV collagenase (Homo sapiens (Human)) | BDBM50491912 (CHEMBL2385445) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | <1 | n/a | n/a | n/a | n/a | n/a | n/a |
ETH Zurich Curated by ChEMBL | Assay Description Inhibition of human full length MMP2 using Mca-Pro-Leu-Gly-Leu-Dpa(Dnp)-Ala-Arg-NH2 as substrate measured up to 120 mins by fluorescence assay | J Med Chem 56: 4912-20 (2013) Article DOI: 10.1021/jm400156p BindingDB Entry DOI: 10.7270/Q2959MHQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Matrix metalloproteinase-9 (Homo sapiens (Human)) | BDBM50063139 ((R)-2-[4-(4-Bromo-benzoylamino)-benzenesulfonylami...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
ETH Zurich Curated by ChEMBL | Assay Description Inhibition of human full length MMP9 using Mca-Pro-Leu-Gly-Leu-Dpa(Dnp)-Ala-Arg-NH2 as substrate measured up to 120 mins by fluorescence assay | J Med Chem 56: 4912-20 (2013) Article DOI: 10.1021/jm400156p BindingDB Entry DOI: 10.7270/Q2959MHQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostaglandin F2-alpha receptor (Homo sapiens (Human)) | BDBM520944 (5-[({6-Bromo-2-[3-ethylpiperidin-1-yl]-3-methylqui...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS... | Citation and Details BindingDB Entry DOI: 10.7270/Q25X2D3J | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Matrix metalloproteinase-9 (Homo sapiens (Human)) | BDBM50491906 (CHEMBL2385442) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a |
ETH Zurich Curated by ChEMBL | Assay Description Inhibition of human full length MMP9 using Mca-Pro-Leu-Gly-Leu-Dpa(Dnp)-Ala-Arg-NH2 as substrate measured up to 120 mins by fluorescence assay | J Med Chem 56: 4912-20 (2013) Article DOI: 10.1021/jm400156p BindingDB Entry DOI: 10.7270/Q2959MHQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostaglandin F2-alpha receptor (Homo sapiens (Human)) | BDBM523442 (US11136296, Example 173 | US11136296, Example 222 ...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS... | Citation and Details BindingDB Entry DOI: 10.7270/Q2NS0Z2X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostaglandin F2-alpha receptor (Homo sapiens (Human)) | BDBM520852 (US11149018, Example 136) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS... | Citation and Details BindingDB Entry DOI: 10.7270/Q25X2D3J | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human)) | BDBM490548 (5-fluoro-4-(3-oxo[1,2,4]triazolo[4,3-a]pyridin-2(3...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.20 | n/a | n/a | n/a | n/a | n/a | n/a |
BAYER AKTIENGESELLSCHAFT; BAYER PHARMA AKTIENGESELLSCHAFT; THE BROAD INSTITUTE, INC.; PRESIDENT AND FELLOWS OF HARVARD COLLEGE; THE GENERAL HOSPITAL CORPORATION US Patent | Assay Description Assay—2: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-Dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e... | US Patent US10968216 (2021) BindingDB Entry DOI: 10.7270/Q2WM1HJN | |||||||||||
More data for this Ligand-Target Pair |
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