Compile Data Set for Download or QSAR

Found 35 hits with Last Name = 'stoppie' and Initial = 'p'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D (RAT-Rattus norvegicus)	BDBM50110039 (1-[2-(3-Cyclopropylmethoxy-4-methoxy-phenyl)-propy...) Show SMILES COc1ccc(cc1OCC1CC1)C(C)Cn1cc[nH]c1=O Show InChI InChI=1S/C17H22N2O3/c1-12(10-19-8-7-18-17(19)20)14-5-6-15(21-2)16(9-14)22-11-13-3-4-13/h5-9,12-13H,3-4,10-11H2,1-2H3,(H,18,20)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	3.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen-Cilag Curated by ChEMBL					Assay Description Displacement of [3H]rolipram from rat forebrain membrane				Bioorg Med Chem Lett 12: 653-8 (2002) BindingDB Entry DOI: 10.7270/Q2DV1KF6
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D (RAT-Rattus norvegicus)	BDBM14361 ((R,S)-Rolipram | 4-(3-cyclopentyloxy-4-methoxy-phe...) Show SMILES COc1ccc(cc1OC1CCCC1)C1CNC(=O)C1 Show InChI InChI=1S/C16H21NO3/c1-19-14-7-6-11(12-9-16(18)17-10-12)8-15(14)20-13-4-2-3-5-13/h6-8,12-13H,2-5,9-10H2,1H3,(H,17,18)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PDB PubMed	11	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen-Cilag Curated by ChEMBL					Assay Description Inhibition of [3H]rolipram binding to Phosphodiesterase 4 of rat forebrain membrane				Bioorg Med Chem Lett 12: 653-8 (2002) BindingDB Entry DOI: 10.7270/Q2DV1KF6
					More data for this Ligand-Target Pair				3D Structure (crystal)
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D (RAT-Rattus norvegicus)	BDBM14775 (3-(cyclopentyloxy)-N-(3,5-dichloropyridin-4-yl)-4-...) Show SMILES COc1ccc(cc1OC1CCCC1)C(=O)Nc1c(Cl)cncc1Cl Show InChI InChI=1S/C18H18Cl2N2O3/c1-24-15-7-6-11(8-16(15)25-12-4-2-3-5-12)18(23)22-17-13(19)9-21-10-14(17)20/h6-10,12H,2-5H2,1H3,(H,21,22,23)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	PDB PubMed	26	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen-Cilag Curated by ChEMBL					Assay Description Inhibition of [3H]rolipram binding to Phosphodiesterase 4 of rat forebrain membrane				Bioorg Med Chem Lett 12: 653-8 (2002) BindingDB Entry DOI: 10.7270/Q2DV1KF6
					More data for this Ligand-Target Pair				3D Structure (crystal)
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D (RAT-Rattus norvegicus)	BDBM50451480 (CHEMBL2093042) Show SMILES COc1ccc(cc1OC1Cc2ccccc2C1)[C@@H](C)Cn1cc[nH]\c1=N/C#N |r| Show InChI InChI=1S/C23H24N4O2/c1-16(14-27-10-9-25-23(27)26-15-24)17-7-8-21(28-2)22(13-17)29-20-11-18-5-3-4-6-19(18)12-20/h3-10,13,16,20H,11-12,14H2,1-2H3,(H,25,26)/t16-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	63	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen-Cilag Curated by ChEMBL					Assay Description Displacement of [3H]rolipram from rat forebrain membrane				Bioorg Med Chem Lett 12: 653-8 (2002) BindingDB Entry DOI: 10.7270/Q2DV1KF6
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D (RAT-Rattus norvegicus)	BDBM50110030 (1-{2-[3-(Indan-2-yloxy)-4-methoxy-phenyl]-propyl}-...) Show SMILES COc1ccc(cc1OC1Cc2ccccc2C1)C(C)Cn1ccnc1NC#N Show InChI InChI=1S/C23H24N4O2/c1-16(14-27-10-9-25-23(27)26-15-24)17-7-8-21(28-2)22(13-17)29-20-11-18-5-3-4-6-19(18)12-20/h3-10,13,16,20H,11-12,14H2,1-2H3,(H,25,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	180	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen-Cilag Curated by ChEMBL					Assay Description Displacement of [3H]rolipram from rat forebrain membrane				Bioorg Med Chem Lett 12: 653-8 (2002) BindingDB Entry DOI: 10.7270/Q2DV1KF6
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D (RAT-Rattus norvegicus)	BDBM50366802 (CHEMBL1788264) Show SMILES COc1ccc(cc1OC1Cc2ccccc2C1)[C@H](C)Cn1ccnc1NC#N |r| Show InChI InChI=1S/C23H24N4O2/c1-16(14-27-10-9-25-23(27)26-15-24)17-7-8-21(28-2)22(13-17)29-20-11-18-5-3-4-6-19(18)12-20/h3-10,13,16,20H,11-12,14H2,1-2H3,(H,25,26)/t16-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	220	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen-Cilag Curated by ChEMBL					Assay Description Displacement of [3H]rolipram from rat forebrain membrane				Bioorg Med Chem Lett 12: 653-8 (2002) BindingDB Entry DOI: 10.7270/Q2DV1KF6
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM14775 (3-(cyclopentyloxy)-N-(3,5-dichloropyridin-4-yl)-4-...) Show SMILES COc1ccc(cc1OC1CCCC1)C(=O)Nc1c(Cl)cncc1Cl Show InChI InChI=1S/C18H18Cl2N2O3/c1-24-15-7-6-11(8-16(15)25-12-4-2-3-5-12)18(23)22-17-13(19)9-21-10-14(17)20/h6-10,12H,2-5H2,1H3,(H,21,22,23)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	PDB PubMed	n/a	n/a	0.200	n/a	n/a	n/a	n/a	n/a	n/a
Janssen-Cilag Curated by ChEMBL					Assay Description Inhibitory activity against recombinant phosphodiesterase 4B (PDE4B) of human mononuclear lymphocytes				Bioorg Med Chem Lett 12: 653-8 (2002) BindingDB Entry DOI: 10.7270/Q2DV1KF6
					More data for this Ligand-Target Pair				3D Structure (crystal)
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50219313 (CHEMBL157812) Show SMILES CC(Cn1ccnc1O)c1ccc(OC(F)F)c(OC2CCCC2)c1 Show InChI InChI=1S/C18H22F2N2O3/c1-12(11-22-9-8-21-18(22)23)13-6-7-15(25-17(19)20)16(10-13)24-14-4-2-3-5-14/h6-10,12,14,17H,2-5,11H2,1H3,(H,21,23)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
Janssen-Cilag Curated by ChEMBL					Assay Description Inhibitory activity against recombinant phosphodiesterase 4B (PDE4B) of human mononuclear lymphocytes				Bioorg Med Chem Lett 12: 653-8 (2002) BindingDB Entry DOI: 10.7270/Q2DV1KF6
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50110030 (1-{2-[3-(Indan-2-yloxy)-4-methoxy-phenyl]-propyl}-...) Show SMILES COc1ccc(cc1OC1Cc2ccccc2C1)C(C)Cn1ccnc1NC#N Show InChI InChI=1S/C23H24N4O2/c1-16(14-27-10-9-25-23(27)26-15-24)17-7-8-21(28-2)22(13-17)29-20-11-18-5-3-4-6-19(18)12-20/h3-10,13,16,20H,11-12,14H2,1-2H3,(H,25,26)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	19	n/a	n/a	n/a	n/a	n/a	n/a
Janssen-Cilag Curated by ChEMBL					Assay Description Inhibitory activity against recombinant phosphodiesterase 4B (PDE4B) of human mononuclear lymphocytes				Bioorg Med Chem Lett 12: 653-8 (2002) BindingDB Entry DOI: 10.7270/Q2DV1KF6
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50451480 (CHEMBL2093042) Show SMILES COc1ccc(cc1OC1Cc2ccccc2C1)[C@@H](C)Cn1cc[nH]\c1=N/C#N |r| Show InChI InChI=1S/C23H24N4O2/c1-16(14-27-10-9-25-23(27)26-15-24)17-7-8-21(28-2)22(13-17)29-20-11-18-5-3-4-6-19(18)12-20/h3-10,13,16,20H,11-12,14H2,1-2H3,(H,25,26)/t16-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	19	n/a	n/a	n/a	n/a	n/a	n/a
Janssen-Cilag Curated by ChEMBL					Assay Description Inhibitory activity against recombinant phosphodiesterase 4B (PDE4B) of human mononuclear lymphocytes				Bioorg Med Chem Lett 12: 653-8 (2002) BindingDB Entry DOI: 10.7270/Q2DV1KF6
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50110052 (1-{2-[3-(Bicyclo[2.2.1]hept-2-yloxy)-4-methoxy-phe...) Show SMILES COc1ccc(cc1OC1CC2CCC1C2)C(C)Cn1cc[nH]c1=O |TLB:8:9:15:13.12| Show InChI InChI=1S/C20H26N2O3/c1-13(12-22-8-7-21-20(22)23)15-5-6-17(24-2)19(11-15)25-18-10-14-3-4-16(18)9-14/h5-8,11,13-14,16,18H,3-4,9-10,12H2,1-2H3,(H,21,23)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	21	n/a	n/a	n/a	n/a	n/a	n/a
Janssen-Cilag Curated by ChEMBL					Assay Description Inhibitory activity against recombinant phosphodiesterase 4B (PDE4B) of human mononuclear lymphocytes				Bioorg Med Chem Lett 12: 653-8 (2002) BindingDB Entry DOI: 10.7270/Q2DV1KF6
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50110046 (1-[2-(3-Cyclopropylmethoxy-4-difluoromethoxy-pheny...) Show SMILES CC(Cn1ccnc1NC#N)c1ccc(OC(F)F)c(OCC2CC2)c1 Show InChI InChI=1S/C18H20F2N4O2/c1-12(9-24-7-6-22-18(24)23-11-21)14-4-5-15(26-17(19)20)16(8-14)25-10-13-2-3-13/h4-8,12-13,17H,2-3,9-10H2,1H3,(H,22,23)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	22	n/a	n/a	n/a	n/a	n/a	n/a
Janssen-Cilag Curated by ChEMBL					Assay Description Inhibitory activity against recombinant phosphodiesterase 4B (PDE4B) of human mononuclear lymphocytes				Bioorg Med Chem Lett 12: 653-8 (2002) BindingDB Entry DOI: 10.7270/Q2DV1KF6
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50110038 (1-{2-Fluoro-2-[3-(indan-2-yloxy)-4-methoxy-phenyl]...) Show SMILES COc1ccc(cc1OC1Cc2ccccc2C1)C(F)Cn1cc[nH]c1=O Show InChI InChI=1S/C21H21FN2O3/c1-26-19-7-6-16(18(22)13-24-9-8-23-21(24)25)12-20(19)27-17-10-14-4-2-3-5-15(14)11-17/h2-9,12,17-18H,10-11,13H2,1H3,(H,23,25)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	24	n/a	n/a	n/a	n/a	n/a	n/a
Janssen-Cilag Curated by ChEMBL					Assay Description Inhibitory activity against recombinant phosphodiesterase 4B (PDE4B) of human mononuclear lymphocytes				Bioorg Med Chem Lett 12: 653-8 (2002) BindingDB Entry DOI: 10.7270/Q2DV1KF6
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50110040 (1-[2-(3-Cyclopentyloxy-4-methoxy-phenyl)-propyl]-1...) Show SMILES COc1ccc(cc1OC1CCCC1)C(C)Cn1cc[nH]c1=O Show InChI InChI=1S/C18H24N2O3/c1-13(12-20-10-9-19-18(20)21)14-7-8-16(22-2)17(11-14)23-15-5-3-4-6-15/h7-11,13,15H,3-6,12H2,1-2H3,(H,19,21)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	24	n/a	n/a	n/a	n/a	n/a	n/a
Janssen-Cilag Curated by ChEMBL					Assay Description Inhibitory activity against recombinant phosphodiesterase 4B (PDE4B) of human mononuclear lymphocytes				Bioorg Med Chem Lett 12: 653-8 (2002) BindingDB Entry DOI: 10.7270/Q2DV1KF6
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50110034 (1-{2-[4-Difluoromethoxy-3-(5-phenyl-pentyloxy)-phe...) Show SMILES CC(Cn1ccnc1NC#N)c1ccc(OC(F)F)c(OCCCCCc2ccccc2)c1 Show InChI InChI=1S/C25H28F2N4O2/c1-19(17-31-14-13-29-25(31)30-18-28)21-11-12-22(33-24(26)27)23(16-21)32-15-7-3-6-10-20-8-4-2-5-9-20/h2,4-5,8-9,11-14,16,19,24H,3,6-7,10,15,17H2,1H3,(H,29,30)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	28	n/a	n/a	n/a	n/a	n/a	n/a
Janssen-Cilag Curated by ChEMBL					Assay Description Inhibitory activity against recombinant phosphodiesterase 4B (PDE4B) of human mononuclear lymphocytes				Bioorg Med Chem Lett 12: 653-8 (2002) BindingDB Entry DOI: 10.7270/Q2DV1KF6
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50110037 (1-[2-(3-Cyclopentyloxy-4-methoxy-phenyl)-propyl]-1...) Show SMILES COc1ccc(cc1OC1CCCC1)C(C)Cn1ccnc1NC#N Show InChI InChI=1S/C19H24N4O2/c1-14(12-23-10-9-21-19(23)22-13-20)15-7-8-17(24-2)18(11-15)25-16-5-3-4-6-16/h7-11,14,16H,3-6,12H2,1-2H3,(H,21,22)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
Janssen-Cilag Curated by ChEMBL					Assay Description Inhibitory activity against recombinant phosphodiesterase 4B (PDE4B) of human mononuclear lymphocytes				Bioorg Med Chem Lett 12: 653-8 (2002) BindingDB Entry DOI: 10.7270/Q2DV1KF6
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50110051 (1-{2-[4-Methoxy-3-(5-phenyl-pentyloxy)-phenyl]-pro...) Show SMILES COc1ccc(cc1OCCCCCc1ccccc1)C(C)Cn1ccnc1NC#N Show InChI InChI=1S/C25H30N4O2/c1-20(18-29-15-14-27-25(29)28-19-26)22-12-13-23(30-2)24(17-22)31-16-8-4-7-11-21-9-5-3-6-10-21/h3,5-6,9-10,12-15,17,20H,4,7-8,11,16,18H2,1-2H3,(H,27,28)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	36	n/a	n/a	n/a	n/a	n/a	n/a
Janssen-Cilag Curated by ChEMBL					Assay Description Inhibitory activity against recombinant phosphodiesterase 4B (PDE4B) of human mononuclear lymphocytes				Bioorg Med Chem Lett 12: 653-8 (2002) BindingDB Entry DOI: 10.7270/Q2DV1KF6
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50110047 (1-[1-(3-Cyclopentyloxy-4-difluoromethoxy-phenyl)-c...) Show SMILES FC(F)Oc1ccc(cc1OC1CCCC1)C1(Cn2cc[nH]c2=O)CC1 Show InChI InChI=1S/C19H22F2N2O3/c20-17(21)26-15-6-5-13(11-16(15)25-14-3-1-2-4-14)19(7-8-19)12-23-10-9-22-18(23)24/h5-6,9-11,14,17H,1-4,7-8,12H2,(H,22,24)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	39	n/a	n/a	n/a	n/a	n/a	n/a
Janssen-Cilag Curated by ChEMBL					Assay Description Inhibitory activity against recombinant phosphodiesterase 4B (PDE4B) of human mononuclear lymphocytes				Bioorg Med Chem Lett 12: 653-8 (2002) BindingDB Entry DOI: 10.7270/Q2DV1KF6
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50110035 (1-[2-(3-Cyclopropylmethoxy-4-methoxy-phenyl)-propy...) Show SMILES COc1ccc(cc1OCC1CC1)C(C)Cn1ccnc1NC#N Show InChI InChI=1S/C18H22N4O2/c1-13(10-22-8-7-20-18(22)21-12-19)15-5-6-16(23-2)17(9-15)24-11-14-3-4-14/h5-9,13-14H,3-4,10-11H2,1-2H3,(H,20,21)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	57	n/a	n/a	n/a	n/a	n/a	n/a
Janssen-Cilag Curated by ChEMBL					Assay Description Inhibitory activity against recombinant phosphodiesterase 4B (PDE4B) of human mononuclear lymphocytes				Bioorg Med Chem Lett 12: 653-8 (2002) BindingDB Entry DOI: 10.7270/Q2DV1KF6
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50366802 (CHEMBL1788264) Show SMILES COc1ccc(cc1OC1Cc2ccccc2C1)[C@H](C)Cn1ccnc1NC#N |r| Show InChI InChI=1S/C23H24N4O2/c1-16(14-27-10-9-25-23(27)26-15-24)17-7-8-21(28-2)22(13-17)29-20-11-18-5-3-4-6-19(18)12-20/h3-10,13,16,20H,11-12,14H2,1-2H3,(H,25,26)/t16-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	57	n/a	n/a	n/a	n/a	n/a	n/a
Janssen-Cilag Curated by ChEMBL					Assay Description Inhibitory activity against recombinant phosphodiesterase 4B (PDE4B) of human mononuclear lymphocytes				Bioorg Med Chem Lett 12: 653-8 (2002) BindingDB Entry DOI: 10.7270/Q2DV1KF6
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50110033 (1-{2-[3-(2-Indan-2-yl-ethoxy)-4-methoxy-phenyl]-pr...) Show SMILES COc1ccc(cc1OCCC1Cc2ccccc2C1)C(C)Cn1ccnc1NC#N Show InChI InChI=1S/C25H28N4O2/c1-18(16-29-11-10-27-25(29)28-17-26)20-7-8-23(30-2)24(15-20)31-12-9-19-13-21-5-3-4-6-22(21)14-19/h3-8,10-11,15,18-19H,9,12-14,16H2,1-2H3,(H,27,28)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	68	n/a	n/a	n/a	n/a	n/a	n/a
Janssen-Cilag Curated by ChEMBL					Assay Description Inhibitory activity against recombinant phosphodiesterase 4B (PDE4B) of human mononuclear lymphocytes				Bioorg Med Chem Lett 12: 653-8 (2002) BindingDB Entry DOI: 10.7270/Q2DV1KF6
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50346088 ((1r,4r)-4-cyano-4-(3-(cyclopentyloxy)-4-methoxyphe...) Show SMILES COc1ccc(cc1OC1CCCC1)[C@]1(CC[C@@H](CC1)C(O)=O)C#N |r,wU:17.22,14.25,(4.79,2.97,;3.46,3.74,;2.12,2.97,;.79,3.74,;-.54,2.97,;-.54,1.43,;.79,.66,;2.12,1.43,;3.46,.66,;3.46,-.88,;4.7,-1.79,;4.23,-3.25,;2.69,-3.25,;2.21,-1.79,;-1.88,.66,;-3.42,.71,;-4.23,-.6,;-3.51,-1.96,;-1.97,-2.01,;-1.16,-.7,;-4.33,-3.26,;-3.6,-4.62,;-5.87,-3.21,;-1.77,2.19,;-1.66,3.73,)| Show InChI InChI=1S/C20H25NO4/c1-24-17-7-6-15(12-18(17)25-16-4-2-3-5-16)20(13-21)10-8-14(9-11-20)19(22)23/h6-7,12,14,16H,2-5,8-11H2,1H3,(H,22,23)/t14-,20-	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PDB PubMed	n/a	n/a	71	n/a	n/a	n/a	n/a	n/a	n/a
Janssen-Cilag Curated by ChEMBL					Assay Description Inhibitory activity against recombinant phosphodiesterase 4B (PDE4B) of human mononuclear lymphocytes				Bioorg Med Chem Lett 12: 653-8 (2002) BindingDB Entry DOI: 10.7270/Q2DV1KF6
					More data for this Ligand-Target Pair				3D Structure (crystal)
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50110039 (1-[2-(3-Cyclopropylmethoxy-4-methoxy-phenyl)-propy...) Show SMILES COc1ccc(cc1OCC1CC1)C(C)Cn1cc[nH]c1=O Show InChI InChI=1S/C17H22N2O3/c1-12(10-19-8-7-18-17(19)20)14-5-6-15(21-2)16(9-14)22-11-13-3-4-13/h5-9,12-13H,3-4,10-11H2,1-2H3,(H,18,20)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	86	n/a	n/a	n/a	n/a	n/a	n/a
Janssen-Cilag Curated by ChEMBL					Assay Description Inhibitory activity against recombinant phosphodiesterase 4B (PDE4B) of human mononuclear lymphocytes				Bioorg Med Chem Lett 12: 653-8 (2002) BindingDB Entry DOI: 10.7270/Q2DV1KF6
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50110036 (1-[2-(3-Cyclopentyloxy-4-methoxy-phenyl)-ethyl]-1,...) Show SMILES COc1ccc(CCn2cc[nH]c2=O)cc1OC1CCCC1 Show InChI InChI=1S/C17H22N2O3/c1-21-15-7-6-13(8-10-19-11-9-18-17(19)20)12-16(15)22-14-4-2-3-5-14/h6-7,9,11-12,14H,2-5,8,10H2,1H3,(H,18,20)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	110	n/a	n/a	n/a	n/a	n/a	n/a
Janssen-Cilag Curated by ChEMBL					Assay Description Inhibitory activity against recombinant phosphodiesterase 4B (PDE4B) of human mononuclear lymphocytes				Bioorg Med Chem Lett 12: 653-8 (2002) BindingDB Entry DOI: 10.7270/Q2DV1KF6
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50110045 (1-{2-[4-Methoxy-3-(tetrahydro-furan-3-yloxy)-pheny...) Show SMILES COc1ccc(cc1OC1CCOC1)C(C)Cn1ccnc1NC#N Show InChI InChI=1S/C18H22N4O3/c1-13(10-22-7-6-20-18(22)21-12-19)14-3-4-16(23-2)17(9-14)25-15-5-8-24-11-15/h3-4,6-7,9,13,15H,5,8,10-11H2,1-2H3,(H,20,21)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	196	n/a	n/a	n/a	n/a	n/a	n/a
Janssen-Cilag Curated by ChEMBL					Assay Description Inhibitory activity against recombinant phosphodiesterase 4B (PDE4B) of human mononuclear lymphocytes				Bioorg Med Chem Lett 12: 653-8 (2002) BindingDB Entry DOI: 10.7270/Q2DV1KF6
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50110029 (1-{2-[4-Methoxy-3-(tetrahydro-furan-3-yloxy)-pheny...) Show SMILES COc1ccc(cc1OC1CCOC1)C(C)Cn1cc[nH]c1=O Show InChI InChI=1S/C17H22N2O4/c1-12(10-19-7-6-18-17(19)20)13-3-4-15(21-2)16(9-13)23-14-5-8-22-11-14/h3-4,6-7,9,12,14H,5,8,10-11H2,1-2H3,(H,18,20)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	241	n/a	n/a	n/a	n/a	n/a	n/a
Janssen-Cilag Curated by ChEMBL					Assay Description Inhibitory activity against recombinant phosphodiesterase 4B (PDE4B) of human mononuclear lymphocytes				Bioorg Med Chem Lett 12: 653-8 (2002) BindingDB Entry DOI: 10.7270/Q2DV1KF6
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50110032 (1-[2-(3-Cyclopentyloxy-4-methoxy-phenyl)-1-methyl-...) Show SMILES COc1ccc(cc1OC1CCCC1)C(C)C(C)n1cc[nH]c1=O Show InChI InChI=1S/C19H26N2O3/c1-13(14(2)21-11-10-20-19(21)22)15-8-9-17(23-3)18(12-15)24-16-6-4-5-7-16/h8-14,16H,4-7H2,1-3H3,(H,20,22)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	277	n/a	n/a	n/a	n/a	n/a	n/a
Janssen-Cilag Curated by ChEMBL					Assay Description Inhibitory activity against recombinant phosphodiesterase 4B (PDE4B) of human mononuclear lymphocytes				Bioorg Med Chem Lett 12: 653-8 (2002) BindingDB Entry DOI: 10.7270/Q2DV1KF6
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50110048 (1-{2-Fluoro-2-[4-methoxy-3-(tetrahydro-furan-3-ylo...) Show SMILES COc1ccc(cc1OC1CCOC1)C(C)(F)Cn1cc[nH]c1=O Show InChI InChI=1S/C17H21FN2O4/c1-17(18,11-20-7-6-19-16(20)21)12-3-4-14(22-2)15(9-12)24-13-5-8-23-10-13/h3-4,6-7,9,13H,5,8,10-11H2,1-2H3,(H,19,21)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	327	n/a	n/a	n/a	n/a	n/a	n/a
Janssen-Cilag Curated by ChEMBL					Assay Description Inhibitory activity against recombinant phosphodiesterase 4B (PDE4B) of human mononuclear lymphocytes				Bioorg Med Chem Lett 12: 653-8 (2002) BindingDB Entry DOI: 10.7270/Q2DV1KF6
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50110041 (1-[1-(3-Cyclopentyloxy-4-methoxy-phenyl)-cycloprop...) Show SMILES COc1ccc(cc1OC1CCCC1)C1(Cn2cc[nH]c2=O)CC1 Show InChI InChI=1S/C19H24N2O3/c1-23-16-7-6-14(12-17(16)24-15-4-2-3-5-15)19(8-9-19)13-21-11-10-20-18(21)22/h6-7,10-12,15H,2-5,8-9,13H2,1H3,(H,20,22)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	341	n/a	n/a	n/a	n/a	n/a	n/a
Janssen-Cilag Curated by ChEMBL					Assay Description Inhibitory activity against recombinant phosphodiesterase 4B (PDE4B) of human mononuclear lymphocytes				Bioorg Med Chem Lett 12: 653-8 (2002) BindingDB Entry DOI: 10.7270/Q2DV1KF6
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50110043 (1-[2-(3-Cyclopentyloxy-4-methoxy-phenyl)-2-methyl-...) Show SMILES COc1ccc(cc1OC1CCCC1)C(C)(C)Cn1cc[nH]c1=O Show InChI InChI=1S/C19H26N2O3/c1-19(2,13-21-11-10-20-18(21)22)14-8-9-16(23-3)17(12-14)24-15-6-4-5-7-15/h8-12,15H,4-7,13H2,1-3H3,(H,20,22)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	367	n/a	n/a	n/a	n/a	n/a	n/a
Janssen-Cilag Curated by ChEMBL					Assay Description Inhibitory activity against recombinant phosphodiesterase 4B (PDE4B) of human mononuclear lymphocytes				Bioorg Med Chem Lett 12: 653-8 (2002) BindingDB Entry DOI: 10.7270/Q2DV1KF6
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50110031 (1-{2-Hydroxy-2-[3-(indan-2-yloxy)-4-methoxy-phenyl...) Show SMILES COc1ccc(cc1OC1Cc2ccccc2C1)C(O)Cn1cc[nH]c1=O Show InChI InChI=1S/C21H22N2O4/c1-26-19-7-6-16(18(24)13-23-9-8-22-21(23)25)12-20(19)27-17-10-14-4-2-3-5-15(14)11-17/h2-9,12,17-18,24H,10-11,13H2,1H3,(H,22,25)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	399	n/a	n/a	n/a	n/a	n/a	n/a
Janssen-Cilag Curated by ChEMBL					Assay Description Inhibitory activity against recombinant phosphodiesterase 4B (PDE4B) of human mononuclear lymphocytes				Bioorg Med Chem Lett 12: 653-8 (2002) BindingDB Entry DOI: 10.7270/Q2DV1KF6
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50110044 (1-[2-(3-Cyclopentyloxy-4-methoxy-phenyl)-2-oxo-eth...) Show SMILES COc1ccc(cc1OC1CCCC1)C(=O)Cn1cc[nH]c1=O Show InChI InChI=1S/C17H20N2O4/c1-22-15-7-6-12(10-16(15)23-13-4-2-3-5-13)14(20)11-19-9-8-18-17(19)21/h6-10,13H,2-5,11H2,1H3,(H,18,21)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	486	n/a	n/a	n/a	n/a	n/a	n/a
Janssen-Cilag Curated by ChEMBL					Assay Description Inhibitory activity against recombinant phosphodiesterase 4B (PDE4B) of human mononuclear lymphocytes				Bioorg Med Chem Lett 12: 653-8 (2002) BindingDB Entry DOI: 10.7270/Q2DV1KF6
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM14361 ((R,S)-Rolipram | 4-(3-cyclopentyloxy-4-methoxy-phe...) Show SMILES COc1ccc(cc1OC1CCCC1)C1CNC(=O)C1 Show InChI InChI=1S/C16H21NO3/c1-19-14-7-6-11(12-9-16(18)17-10-12)8-15(14)20-13-4-2-3-5-13/h6-8,12-13H,2-5,9-10H2,1H3,(H,17,18)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PDB PubMed	n/a	n/a	741	n/a	n/a	n/a	n/a	n/a	n/a
Janssen-Cilag Curated by ChEMBL					Assay Description Inhibitory activity against recombinant phosphodiesterase 4B (PDE4B) of human mononuclear lymphocytes				Bioorg Med Chem Lett 12: 653-8 (2002) BindingDB Entry DOI: 10.7270/Q2DV1KF6
					More data for this Ligand-Target Pair				3D Structure (crystal)
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50110050 (1-{2-Hydroxy-2-[4-methoxy-3-(tetrahydro-furan-3-yl...) Show SMILES COc1ccc(cc1OC1CCOC1)C(C)(O)Cn1cc[nH]c1=O Show InChI InChI=1S/C17H22N2O5/c1-17(21,11-19-7-6-18-16(19)20)12-3-4-14(22-2)15(9-12)24-13-5-8-23-10-13/h3-4,6-7,9,13,21H,5,8,10-11H2,1-2H3,(H,18,20)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Janssen-Cilag Curated by ChEMBL					Assay Description Inhibitory activity against recombinant phosphodiesterase 4B (PDE4B) of human mononuclear lymphocytes				Bioorg Med Chem Lett 12: 653-8 (2002) BindingDB Entry DOI: 10.7270/Q2DV1KF6
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50110049 (1-[2-(3-Cyclopentyloxy-4-trifluoromethoxy-phenyl)-...) Show SMILES CC(Cn1cc[nH]c1=O)c1ccc(OC(F)(F)F)c(OC2CCCC2)c1 Show InChI InChI=1S/C18H21F3N2O3/c1-12(11-23-9-8-22-17(23)24)13-6-7-15(26-18(19,20)21)16(10-13)25-14-4-2-3-5-14/h6-10,12,14H,2-5,11H2,1H3,(H,22,24)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Janssen-Cilag Curated by ChEMBL					Assay Description Inhibitory activity against recombinant phosphodiesterase 4B (PDE4B) of human mononuclear lymphocytes				Bioorg Med Chem Lett 12: 653-8 (2002) BindingDB Entry DOI: 10.7270/Q2DV1KF6
					More data for this Ligand-Target Pair