Found 61 hits with Last Name = 'sun' and Initial = 'sc' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Presenilin-1
(Homo sapiens (Human)) | BDBM50480807
(CHEMBL576553)Show SMILES CCC(CC)[C@H](NS(=O)(=O)c1ccc(Cl)s1)c1ccnn1Cc1ccc(O)cc1 |r| Show InChI InChI=1S/C20H24ClN3O3S2/c1-3-15(4-2)20(23-29(26,27)19-10-9-18(21)28-19)17-11-12-22-24(17)13-14-5-7-16(25)8-6-14/h5-12,15,20,23,25H,3-4,13H2,1-2H3/t20-/m0/s1 | PDB MMDB
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 154 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description Displacement of [3H](S)-5-chloro-N-(3-ethyl-1-hydroxypentan-2-yl)thiophene-2-sulfonamide from gamma secretase in human SH-SY5Y cells after 1 hr |
Bioorg Med Chem 17: 4708-17 (2009)
Article DOI: 10.1016/j.bmc.2009.04.052 BindingDB Entry DOI: 10.7270/Q2VX0KB6 |
More data for this Ligand-Target Pair | |
Gamma-secretase subunit APH-1A/Gamma-secretase subunit PEN-2/Nicastrin [34-709]/Presenilin-1
(Homo sapiens (Human)) | BDBM28937
((2S,3S)-N-[4-(1,1-difluoroethoxy)phenyl]-1-hydroxy...)Show SMILES CC[C@H](C)[C@@H](CO)NS(=O)(=O)c1ccc(OC(C)(F)F)cc1 |r| Show InChI InChI=1S/C14H21F2NO4S/c1-4-10(2)13(9-18)17-22(19,20)12-7-5-11(6-8-12)21-14(3,15)16/h5-8,10,13,17-18H,4,9H2,1-3H3/t10-,13+/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | n/a | 2.35E+4 | n/a | n/a | n/a | n/a |
Wyeth Research
| Assay Description A Chinese Hamster Ovary cell line stably expressing human beta-APP were aliquoted into a 96-well plate, and after attachment the medium was replaced ... |
Bioorg Med Chem Lett 18: 4232-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.05.064 BindingDB Entry DOI: 10.7270/Q26Q1VJM |
More data for this Ligand-Target Pair | |
Gamma-secretase subunit APH-1A/Gamma-secretase subunit PEN-2/Nicastrin [34-709]/Presenilin-1
(Homo sapiens (Human)) | BDBM28941
((2S,3S)-N-(3,5-dichlorophenyl)-1-hydroxy-3-methylp...)Show SMILES CC[C@H](C)[C@@H](CO)NS(=O)(=O)c1cc(Cl)cc(Cl)c1 |r| Show InChI InChI=1S/C12H17Cl2NO3S/c1-3-8(2)12(7-16)15-19(17,18)11-5-9(13)4-10(14)6-11/h4-6,8,12,15-16H,3,7H2,1-2H3/t8-,12+/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 2.35E+4 | n/a | n/a | n/a | n/a |
Wyeth Research
| Assay Description A Chinese Hamster Ovary cell line stably expressing human beta-APP were aliquoted into a 96-well plate, and after attachment the medium was replaced ... |
Bioorg Med Chem Lett 18: 4232-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.05.064 BindingDB Entry DOI: 10.7270/Q26Q1VJM |
More data for this Ligand-Target Pair | |
Gamma-secretase subunit APH-1A/Gamma-secretase subunit PEN-2/Nicastrin [34-709]/Presenilin-1
(Homo sapiens (Human)) | BDBM28942
((2S,3S)-N-(2,5-dichlorophenyl)-1-hydroxy-3-methylp...)Show SMILES CC[C@H](C)[C@@H](CO)NS(=O)(=O)c1cc(Cl)ccc1Cl |r| Show InChI InChI=1S/C12H17Cl2NO3S/c1-3-8(2)11(7-16)15-19(17,18)12-6-9(13)4-5-10(12)14/h4-6,8,11,15-16H,3,7H2,1-2H3/t8-,11+/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 5.48E+4 | n/a | n/a | n/a | n/a |
Wyeth Research
| Assay Description A Chinese Hamster Ovary cell line stably expressing human beta-APP were aliquoted into a 96-well plate, and after attachment the medium was replaced ... |
Bioorg Med Chem Lett 18: 4232-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.05.064 BindingDB Entry DOI: 10.7270/Q26Q1VJM |
More data for this Ligand-Target Pair | |
Gamma-secretase subunit APH-1A/Gamma-secretase subunit PEN-2/Nicastrin [34-709]/Presenilin-1
(Homo sapiens (Human)) | BDBM28943
((2S,3S)-1-hydroxy-3-methyl-N-phenylpentane-2-sulfo...)Show InChI InChI=1S/C12H19NO3S/c1-3-10(2)12(9-14)13-17(15,16)11-7-5-4-6-8-11/h4-8,10,12-14H,3,9H2,1-2H3/t10-,12+/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 4.15E+3 | n/a | n/a | n/a | n/a |
Wyeth Research
| Assay Description A Chinese Hamster Ovary cell line stably expressing human beta-APP were aliquoted into a 96-well plate, and after attachment the medium was replaced ... |
Bioorg Med Chem Lett 18: 4232-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.05.064 BindingDB Entry DOI: 10.7270/Q26Q1VJM |
More data for this Ligand-Target Pair | |
Gamma-secretase subunit APH-1A/Gamma-secretase subunit PEN-2/Nicastrin [34-709]/Presenilin-1
(Homo sapiens (Human)) | BDBM28944
((2S)-2-hydroxy-3-methyl-N-[(1S)-1-{[(1S)-3-methyl-...)Show SMILES CC(C)[C@H](O)C(=O)N[C@@H](C)C(=O)N[C@H]1c2ccccc2CCN(C)C1=O |r| Show InChI InChI=1S/C19H27N3O4/c1-11(2)16(23)18(25)20-12(3)17(24)21-15-14-8-6-5-7-13(14)9-10-22(4)19(15)26/h5-8,11-12,15-16,23H,9-10H2,1-4H3,(H,20,25)(H,21,24)/t12-,15-,16-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| Purchase
MCE PC cid PC sid PDB UniChem
Patents
Similars
| PDB Article PubMed
| n/a | n/a | n/a | n/a | 28 | n/a | n/a | n/a | n/a |
Wyeth Research
| Assay Description A Chinese Hamster Ovary cell line stably expressing human beta-APP were aliquoted into a 96-well plate, and after attachment the medium was replaced ... |
Bioorg Med Chem Lett 18: 4232-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.05.064 BindingDB Entry DOI: 10.7270/Q26Q1VJM |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Gamma-secretase subunit APH-1A/Gamma-secretase subunit PEN-2/Nicastrin [34-709]/Presenilin-1
(Homo sapiens (Human)) | BDBM28945
([(4-chlorophenyl)sulfamoyl][(2S,3S)-1-hydroxy-3-me...)Show SMILES CC[C@H](C)[C@@H](CO)NS(=O)(=O)Nc1ccc(Cl)cc1 |r| Show InChI InChI=1S/C12H19ClN2O3S/c1-3-9(2)12(8-16)15-19(17,18)14-11-6-4-10(13)5-7-11/h4-7,9,12,14-16H,3,8H2,1-2H3/t9-,12+/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a |
Wyeth Research
| Assay Description A Chinese Hamster Ovary cell line stably expressing human beta-APP were aliquoted into a 96-well plate, and after attachment the medium was replaced ... |
Bioorg Med Chem Lett 18: 4232-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.05.064 BindingDB Entry DOI: 10.7270/Q26Q1VJM |
More data for this Ligand-Target Pair | |
Gamma-secretase subunit APH-1A/Gamma-secretase subunit PEN-2/Nicastrin [34-709]/Presenilin-1
(Homo sapiens (Human)) | BDBM28946
(4-chloro-N-[(2S,3S)-1-hydroxy-3-methylpentan-2-yl]...)Show InChI InChI=1S/C13H18ClNO2/c1-3-9(2)12(8-16)15-13(17)10-4-6-11(14)7-5-10/h4-7,9,12,16H,3,8H2,1-2H3,(H,15,17)/t9-,12+/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a |
Wyeth Research
| Assay Description A Chinese Hamster Ovary cell line stably expressing human beta-APP were aliquoted into a 96-well plate, and after attachment the medium was replaced ... |
Bioorg Med Chem Lett 18: 4232-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.05.064 BindingDB Entry DOI: 10.7270/Q26Q1VJM |
More data for this Ligand-Target Pair | |
Gamma-secretase subunit APH-1A/Gamma-secretase subunit PEN-2/Nicastrin [34-709]/Presenilin-1
(Homo sapiens (Human)) | BDBM28948
(2-(4-chlorophenyl)-N-[(2S,3S)-1-hydroxy-3-methylpe...)Show SMILES CC[C@H](C)[C@@H](CO)NC(=O)Cc1ccc(Cl)cc1 |r| Show InChI InChI=1S/C14H20ClNO2/c1-3-10(2)13(9-17)16-14(18)8-11-4-6-12(15)7-5-11/h4-7,10,13,17H,3,8-9H2,1-2H3,(H,16,18)/t10-,13+/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a |
Wyeth Research
| Assay Description A Chinese Hamster Ovary cell line stably expressing human beta-APP were aliquoted into a 96-well plate, and after attachment the medium was replaced ... |
Bioorg Med Chem Lett 18: 4232-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.05.064 BindingDB Entry DOI: 10.7270/Q26Q1VJM |
More data for this Ligand-Target Pair | |
Gamma-secretase subunit APH-1A/Gamma-secretase subunit PEN-2/Nicastrin [34-709]/Presenilin-1
(Homo sapiens (Human)) | BDBM28950
((2S)-N-(4-chlorophenyl)-1-hydroxypropane-2-sulfona...)Show InChI InChI=1S/C9H12ClNO3S/c1-7(6-12)11-15(13,14)9-4-2-8(10)3-5-9/h2-5,7,11-12H,6H2,1H3/t7-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| Purchase
PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a |
Wyeth Research
| Assay Description A Chinese Hamster Ovary cell line stably expressing human beta-APP were aliquoted into a 96-well plate, and after attachment the medium was replaced ... |
Bioorg Med Chem Lett 18: 4232-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.05.064 BindingDB Entry DOI: 10.7270/Q26Q1VJM |
More data for this Ligand-Target Pair | |
Gamma-secretase subunit APH-1A/Gamma-secretase subunit PEN-2/Nicastrin [34-709]/Presenilin-1
(Homo sapiens (Human)) | BDBM28952
((2S)-N-(4-chlorophenyl)-1-hydroxy-3-methylbutane-2...)Show InChI InChI=1S/C11H16ClNO3S/c1-8(2)11(7-14)13-17(15,16)10-5-3-9(12)4-6-10/h3-6,8,11,13-14H,7H2,1-2H3/t11-/m1/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| Purchase
PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 4.58E+3 | n/a | n/a | n/a | n/a |
Wyeth Research
| Assay Description A Chinese Hamster Ovary cell line stably expressing human beta-APP were aliquoted into a 96-well plate, and after attachment the medium was replaced ... |
Bioorg Med Chem Lett 18: 4232-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.05.064 BindingDB Entry DOI: 10.7270/Q26Q1VJM |
More data for this Ligand-Target Pair | |
Gamma-secretase subunit APH-1A/Gamma-secretase subunit PEN-2/Nicastrin [34-709]/Presenilin-1
(Homo sapiens (Human)) | BDBM28923
((2S)-N-(4-chlorophenyl)-3-ethyl-1-hydroxypentane-2...)Show SMILES CCC(CC)[C@@H](CO)NS(=O)(=O)c1ccc(Cl)cc1 |r| Show InChI InChI=1S/C13H20ClNO3S/c1-3-10(4-2)13(9-16)15-19(17,18)12-7-5-11(14)6-8-12/h5-8,10,13,15-16H,3-4,9H2,1-2H3/t13-/m1/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 294 | n/a | n/a | n/a | n/a |
Wyeth Research
| Assay Description A Chinese Hamster Ovary cell line stably expressing human beta-APP were aliquoted into a 96-well plate, and after attachment the medium was replaced ... |
Bioorg Med Chem Lett 18: 4232-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.05.064 BindingDB Entry DOI: 10.7270/Q26Q1VJM |
More data for this Ligand-Target Pair | |
Gamma-secretase subunit APH-1A/Gamma-secretase subunit PEN-2/Nicastrin [34-709]/Presenilin-1
(Homo sapiens (Human)) | BDBM28955
((2S,3R)-N-(4-chlorophenyl)-1-hydroxy-3-methylpenta...)Show SMILES CC[C@@H](C)[C@@H](CO)NS(=O)(=O)c1ccc(Cl)cc1 |r| Show InChI InChI=1S/C12H18ClNO3S/c1-3-9(2)12(8-15)14-18(16,17)11-6-4-10(13)5-7-11/h4-7,9,12,14-15H,3,8H2,1-2H3/t9-,12-/m1/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 758 | n/a | n/a | n/a | n/a |
Wyeth Research
| Assay Description A Chinese Hamster Ovary cell line stably expressing human beta-APP were aliquoted into a 96-well plate, and after attachment the medium was replaced ... |
Bioorg Med Chem Lett 18: 4232-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.05.064 BindingDB Entry DOI: 10.7270/Q26Q1VJM |
More data for this Ligand-Target Pair | |
Gamma-secretase subunit APH-1A/Gamma-secretase subunit PEN-2/Nicastrin [34-709]/Presenilin-1
(Homo sapiens (Human)) | BDBM28957
((1S)-N-(4-chlorophenyl)-2-hydroxy-1-phenylethane-1...)Show SMILES OC[C@@H](NS(=O)(=O)c1ccc(Cl)cc1)c1ccccc1 |r| Show InChI InChI=1S/C14H14ClNO3S/c15-12-6-8-13(9-7-12)20(18,19)16-14(10-17)11-4-2-1-3-5-11/h1-9,14,16-17H,10H2/t14-/m1/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| Purchase
PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 6.88E+4 | n/a | n/a | n/a | n/a |
Wyeth Research
| Assay Description A Chinese Hamster Ovary cell line stably expressing human beta-APP were aliquoted into a 96-well plate, and after attachment the medium was replaced ... |
Bioorg Med Chem Lett 18: 4232-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.05.064 BindingDB Entry DOI: 10.7270/Q26Q1VJM |
More data for this Ligand-Target Pair | |
Gamma-secretase subunit APH-1A/Gamma-secretase subunit PEN-2/Nicastrin [34-709]/Presenilin-1
(Homo sapiens (Human)) | BDBM28958
((3S,4S)-N-(4-chlorophenyl)-2-hydroxy-4-methylhexan...)Show SMILES CC[C@H](C)[C@H](NS(=O)(=O)c1ccc(Cl)cc1)C(C)O |r| Show InChI InChI=1S/C13H20ClNO3S/c1-4-9(2)13(10(3)16)15-19(17,18)12-7-5-11(14)6-8-12/h5-10,13,15-16H,4H2,1-3H3/t9-,10?,13-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 4.93E+4 | n/a | n/a | n/a | n/a |
Wyeth Research
| Assay Description A Chinese Hamster Ovary cell line stably expressing human beta-APP were aliquoted into a 96-well plate, and after attachment the medium was replaced ... |
Bioorg Med Chem Lett 18: 4232-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.05.064 BindingDB Entry DOI: 10.7270/Q26Q1VJM |
More data for this Ligand-Target Pair | |
Gamma-secretase subunit APH-1A/Gamma-secretase subunit PEN-2/Nicastrin [34-709]/Presenilin-1
(Homo sapiens (Human)) | BDBM28960
((2R)-2-{[5-chloro-2-(hydroxymethyl)phenyl](4-chlor...)Show SMILES CCCNC(=O)OC[C@@H](C)N(c1cc(Cl)ccc1CO)S(=O)(=O)c1ccc(Cl)cc1 |r| Show InChI InChI=1S/C20H24Cl2N2O5S/c1-3-10-23-20(26)29-13-14(2)24(19-11-17(22)5-4-15(19)12-25)30(27,28)18-8-6-16(21)7-9-18/h4-9,11,14,25H,3,10,12-13H2,1-2H3,(H,23,26)/t14-/m1/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 85 | n/a | n/a | n/a | n/a |
Wyeth Research
| Assay Description A Chinese Hamster Ovary cell line stably expressing human beta-APP were aliquoted into a 96-well plate, and after attachment the medium was replaced ... |
Bioorg Med Chem Lett 18: 4232-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.05.064 BindingDB Entry DOI: 10.7270/Q26Q1VJM |
More data for this Ligand-Target Pair | |
Gamma-secretase subunit APH-1A/Gamma-secretase subunit PEN-2/Nicastrin [34-709]/Presenilin-1
(Homo sapiens (Human)) | BDBM28920
((2S,3S)-N-(4-chlorophenyl)-1-hydroxy-3-methylpenta...)Show SMILES CC[C@H](C)[C@@H](CO)NS(=O)(=O)c1ccc(Cl)cc1 |r| Show InChI InChI=1S/C12H18ClNO3S/c1-3-9(2)12(8-15)14-18(16,17)11-6-4-10(13)5-7-11/h4-7,9,12,14-15H,3,8H2,1-2H3/t9-,12+/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 5.45E+3 | n/a | n/a | n/a | n/a |
Wyeth Research
| Assay Description A Chinese Hamster Ovary cell line stably expressing human beta-APP were aliquoted into a 96-well plate, and after attachment the medium was replaced ... |
J Med Chem 51: 7348-51 (2008)
Article DOI: 10.1021/jm801252w BindingDB Entry DOI: 10.7270/Q2BC3WW2 |
More data for this Ligand-Target Pair | |
Gamma-secretase subunit APH-1A/Gamma-secretase subunit PEN-2/Nicastrin [34-709]/Presenilin-1
(Homo sapiens (Human)) | BDBM28921
((2S,3S)-N-(4-bromophenyl)-1-hydroxy-3-methylpentan...)Show SMILES CC[C@H](C)[C@@H](CO)NS(=O)(=O)c1ccc(Br)cc1 |r| Show InChI InChI=1S/C12H18BrNO3S/c1-3-9(2)12(8-15)14-18(16,17)11-6-4-10(13)5-7-11/h4-7,9,12,14-15H,3,8H2,1-2H3/t9-,12+/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 2.21E+3 | n/a | n/a | n/a | n/a |
Wyeth Research
| Assay Description A Chinese Hamster Ovary cell line stably expressing human beta-APP were aliquoted into a 96-well plate, and after attachment the medium was replaced ... |
J Med Chem 51: 7348-51 (2008)
Article DOI: 10.1021/jm801252w BindingDB Entry DOI: 10.7270/Q2BC3WW2 |
More data for this Ligand-Target Pair | |
Gamma-secretase subunit APH-1A/Gamma-secretase subunit PEN-2/Nicastrin [34-709]/Presenilin-1
(Homo sapiens (Human)) | BDBM28922
((2S)-N-(5-chlorothiophen-2-yl)-4,4,4-trifluoro-1-h...)Show SMILES OC[C@@H](NS(=O)(=O)c1ccc(Cl)s1)C(C(F)(F)F)C(F)(F)F |r| Show InChI InChI=1S/C9H8ClF6NO3S2/c10-5-1-2-6(21-5)22(19,20)17-4(3-18)7(8(11,12)13)9(14,15)16/h1-2,4,7,17-18H,3H2/t4-/m1/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| Purchase
MCE PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 15 | n/a | n/a | n/a | n/a |
Wyeth Research
| Assay Description A Chinese Hamster Ovary cell line stably expressing human beta-APP were aliquoted into a 96-well plate, and after attachment the medium was replaced ... |
J Med Chem 51: 7348-51 (2008)
Article DOI: 10.1021/jm801252w BindingDB Entry DOI: 10.7270/Q2BC3WW2 |
More data for this Ligand-Target Pair | |
Gamma-secretase subunit APH-1A/Gamma-secretase subunit PEN-2/Nicastrin [34-709]/Presenilin-1
(Homo sapiens (Human)) | BDBM28923
((2S)-N-(4-chlorophenyl)-3-ethyl-1-hydroxypentane-2...)Show SMILES CCC(CC)[C@@H](CO)NS(=O)(=O)c1ccc(Cl)cc1 |r| Show InChI InChI=1S/C13H20ClNO3S/c1-3-10(4-2)13(9-16)15-19(17,18)12-7-5-11(14)6-8-12/h5-8,10,13,15-16H,3-4,9H2,1-2H3/t13-/m1/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 294 | n/a | n/a | n/a | n/a |
Wyeth Research
| Assay Description A Chinese Hamster Ovary cell line stably expressing human beta-APP were aliquoted into a 96-well plate, and after attachment the medium was replaced ... |
J Med Chem 51: 7348-51 (2008)
Article DOI: 10.1021/jm801252w BindingDB Entry DOI: 10.7270/Q2BC3WW2 |
More data for this Ligand-Target Pair | |
Gamma-secretase subunit APH-1A/Gamma-secretase subunit PEN-2/Nicastrin [34-709]/Presenilin-1
(Homo sapiens (Human)) | BDBM28924
((2S,3S)-N-(5-chlorothiophen-2-yl)-1-hydroxy-3-meth...)Show SMILES CC[C@H](C)[C@@H](CO)NS(=O)(=O)c1ccc(Cl)s1 |r| Show InChI InChI=1S/C10H16ClNO3S2/c1-3-7(2)8(6-13)12-17(14,15)10-5-4-9(11)16-10/h4-5,7-8,12-13H,3,6H2,1-2H3/t7-,8+/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 297 | n/a | n/a | n/a | n/a |
Wyeth Research
| Assay Description A Chinese Hamster Ovary cell line stably expressing human beta-APP were aliquoted into a 96-well plate, and after attachment the medium was replaced ... |
J Med Chem 51: 7348-51 (2008)
Article DOI: 10.1021/jm801252w BindingDB Entry DOI: 10.7270/Q2BC3WW2 |
More data for this Ligand-Target Pair | |
Gamma-secretase subunit APH-1A/Gamma-secretase subunit PEN-2/Nicastrin [34-709]/Presenilin-1
(Homo sapiens (Human)) | BDBM28925
((2S)-N-(5-chlorothiophen-2-yl)-3-ethyl-1-hydroxype...)Show InChI InChI=1S/C11H18ClNO3S2/c1-3-8(4-2)9(7-14)13-18(15,16)11-6-5-10(12)17-11/h5-6,8-9,13-14H,3-4,7H2,1-2H3/t9-/m1/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| Purchase
PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 25 | n/a | n/a | n/a | n/a |
Wyeth Research
| Assay Description A Chinese Hamster Ovary cell line stably expressing human beta-APP were aliquoted into a 96-well plate, and after attachment the medium was replaced ... |
J Med Chem 51: 7348-51 (2008)
Article DOI: 10.1021/jm801252w BindingDB Entry DOI: 10.7270/Q2BC3WW2 |
More data for this Ligand-Target Pair | |
Gamma-secretase subunit APH-1A/Gamma-secretase subunit PEN-2/Nicastrin [34-709]/Presenilin-1
(Homo sapiens (Human)) | BDBM28926
((2S)-N-(5-chlorothiophen-2-yl)-5,5,5-trifluoro-1-h...)Show SMILES OC[C@@H](NS(=O)(=O)c1ccc(Cl)s1)C(CC(F)(F)F)CC(F)(F)F |r| Show InChI InChI=1S/C11H12ClF6NO3S2/c12-8-1-2-9(23-8)24(21,22)19-7(5-20)6(3-10(13,14)15)4-11(16,17)18/h1-2,6-7,19-20H,3-5H2/t7-/m1/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 16 | n/a | n/a | n/a | n/a |
Wyeth Research
| Assay Description A Chinese Hamster Ovary cell line stably expressing human beta-APP were aliquoted into a 96-well plate, and after attachment the medium was replaced ... |
J Med Chem 51: 7348-51 (2008)
Article DOI: 10.1021/jm801252w BindingDB Entry DOI: 10.7270/Q2BC3WW2 |
More data for this Ligand-Target Pair | |
Gamma-secretase subunit APH-1A/Gamma-secretase subunit PEN-2/Nicastrin [34-709]/Presenilin-1
(Homo sapiens (Human)) | BDBM28927
((2R)-N-(5-chlorothiophen-2-yl)-4,4,4-trifluoro-1-h...)Show SMILES OC[C@H](NS(=O)(=O)c1ccc(Cl)s1)C(C(F)(F)F)C(F)(F)F |r| Show InChI InChI=1S/C9H8ClF6NO3S2/c10-5-1-2-6(21-5)22(19,20)17-4(3-18)7(8(11,12)13)9(14,15)16/h1-2,4,7,17-18H,3H2/t4-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| Purchase
PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 1.07E+4 | n/a | n/a | n/a | n/a |
Wyeth Research
| Assay Description A Chinese Hamster Ovary cell line stably expressing human beta-APP were aliquoted into a 96-well plate, and after attachment the medium was replaced ... |
J Med Chem 51: 7348-51 (2008)
Article DOI: 10.1021/jm801252w BindingDB Entry DOI: 10.7270/Q2BC3WW2 |
More data for this Ligand-Target Pair | |
Gamma-secretase subunit APH-1A/Gamma-secretase subunit PEN-2/Nicastrin [34-709]/Presenilin-1
(Homo sapiens (Human)) | BDBM28920
((2S,3S)-N-(4-chlorophenyl)-1-hydroxy-3-methylpenta...)Show SMILES CC[C@H](C)[C@@H](CO)NS(=O)(=O)c1ccc(Cl)cc1 |r| Show InChI InChI=1S/C12H18ClNO3S/c1-3-9(2)12(8-15)14-18(16,17)11-6-4-10(13)5-7-11/h4-7,9,12,14-15H,3,8H2,1-2H3/t9-,12+/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 5.45E+3 | n/a | n/a | n/a | n/a |
Wyeth Research
| Assay Description A Chinese Hamster Ovary cell line stably expressing human beta-APP were aliquoted into a 96-well plate, and after attachment the medium was replaced ... |
Bioorg Med Chem Lett 18: 4232-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.05.064 BindingDB Entry DOI: 10.7270/Q26Q1VJM |
More data for this Ligand-Target Pair | |
Gamma-secretase subunit APH-1A/Gamma-secretase subunit PEN-2/Nicastrin [34-709]/Presenilin-1
(Homo sapiens (Human)) | BDBM28929
((2S,3S)-N-(2-chlorophenyl)-1-hydroxy-3-methylpenta...)Show SMILES CC[C@H](C)[C@@H](CO)NS(=O)(=O)c1ccccc1Cl |r| Show InChI InChI=1S/C12H18ClNO3S/c1-3-9(2)11(8-15)14-18(16,17)12-7-5-4-6-10(12)13/h4-7,9,11,14-15H,3,8H2,1-2H3/t9-,11+/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 5.66E+4 | n/a | n/a | n/a | n/a |
Wyeth Research
| Assay Description A Chinese Hamster Ovary cell line stably expressing human beta-APP were aliquoted into a 96-well plate, and after attachment the medium was replaced ... |
Bioorg Med Chem Lett 18: 4232-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.05.064 BindingDB Entry DOI: 10.7270/Q26Q1VJM |
More data for this Ligand-Target Pair | |
Gamma-secretase subunit APH-1A/Gamma-secretase subunit PEN-2/Nicastrin [34-709]/Presenilin-1
(Homo sapiens (Human)) | BDBM28921
((2S,3S)-N-(4-bromophenyl)-1-hydroxy-3-methylpentan...)Show SMILES CC[C@H](C)[C@@H](CO)NS(=O)(=O)c1ccc(Br)cc1 |r| Show InChI InChI=1S/C12H18BrNO3S/c1-3-9(2)12(8-15)14-18(16,17)11-6-4-10(13)5-7-11/h4-7,9,12,14-15H,3,8H2,1-2H3/t9-,12+/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 2.21E+3 | n/a | n/a | n/a | n/a |
Wyeth Research
| Assay Description A Chinese Hamster Ovary cell line stably expressing human beta-APP were aliquoted into a 96-well plate, and after attachment the medium was replaced ... |
Bioorg Med Chem Lett 18: 4232-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.05.064 BindingDB Entry DOI: 10.7270/Q26Q1VJM |
More data for this Ligand-Target Pair | |
Gamma-secretase subunit APH-1A/Gamma-secretase subunit PEN-2/Nicastrin [34-709]/Presenilin-1
(Homo sapiens (Human)) | BDBM28932
((2S,3S)-1-hydroxy-3-methyl-N-(4-methylphenyl)penta...)Show SMILES CC[C@H](C)[C@@H](CO)NS(=O)(=O)c1ccc(C)cc1 |r| Show InChI InChI=1S/C13H21NO3S/c1-4-11(3)13(9-15)14-18(16,17)12-7-5-10(2)6-8-12/h5-8,11,13-15H,4,9H2,1-3H3/t11-,13+/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 1.43E+4 | n/a | n/a | n/a | n/a |
Wyeth Research
| Assay Description A Chinese Hamster Ovary cell line stably expressing human beta-APP were aliquoted into a 96-well plate, and after attachment the medium was replaced ... |
Bioorg Med Chem Lett 18: 4232-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.05.064 BindingDB Entry DOI: 10.7270/Q26Q1VJM |
More data for this Ligand-Target Pair | |
Gamma-secretase subunit APH-1A/Gamma-secretase subunit PEN-2/Nicastrin [34-709]/Presenilin-1
(Homo sapiens (Human)) | BDBM28934
((2S,3S)-N-(4-acetylphenyl)-1-hydroxy-3-methylpenta...)Show SMILES CC[C@H](C)[C@@H](CO)NS(=O)(=O)c1ccc(cc1)C(C)=O |r| Show InChI InChI=1S/C14H21NO4S/c1-4-10(2)14(9-16)15-20(18,19)13-7-5-12(6-8-13)11(3)17/h5-8,10,14-16H,4,9H2,1-3H3/t10-,14+/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 6.02E+3 | n/a | n/a | n/a | n/a |
Wyeth Research
| Assay Description A Chinese Hamster Ovary cell line stably expressing human beta-APP were aliquoted into a 96-well plate, and after attachment the medium was replaced ... |
Bioorg Med Chem Lett 18: 4232-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.05.064 BindingDB Entry DOI: 10.7270/Q26Q1VJM |
More data for this Ligand-Target Pair | |
Gamma-secretase subunit APH-1A/Gamma-secretase subunit PEN-2/Nicastrin [34-709]/Presenilin-1
(Homo sapiens (Human)) | BDBM28936
((2S,3S)-1-hydroxy-3-methyl-N-(4-nitrophenyl)pentan...)Show SMILES CC[C@H](C)[C@@H](CO)NS(=O)(=O)c1ccc(cc1)[N+]([O-])=O |r| Show InChI InChI=1S/C12H18N2O5S/c1-3-9(2)12(8-15)13-20(18,19)11-6-4-10(5-7-11)14(16)17/h4-7,9,12-13,15H,3,8H2,1-2H3/t9-,12+/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | n/a | 2.09E+4 | n/a | n/a | n/a | n/a |
Wyeth Research
| Assay Description A Chinese Hamster Ovary cell line stably expressing human beta-APP were aliquoted into a 96-well plate, and after attachment the medium was replaced ... |
Bioorg Med Chem Lett 18: 4232-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.05.064 BindingDB Entry DOI: 10.7270/Q26Q1VJM |
More data for this Ligand-Target Pair | |
Gamma-secretase subunit APH-1A/Gamma-secretase subunit PEN-2/Nicastrin [34-709]/Presenilin-1
(Homo sapiens (Human)) | BDBM28938
((2S,3S)-N-(3,4-dichlorophenyl)-1-hydroxy-3-methylp...)Show SMILES CC[C@H](C)[C@@H](CO)NS(=O)(=O)c1ccc(Cl)c(Cl)c1 |r| Show InChI InChI=1S/C12H17Cl2NO3S/c1-3-8(2)12(7-16)15-19(17,18)9-4-5-10(13)11(14)6-9/h4-6,8,12,15-16H,3,7H2,1-2H3/t8-,12+/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 3.70E+4 | n/a | n/a | n/a | n/a |
Wyeth Research
| Assay Description A Chinese Hamster Ovary cell line stably expressing human beta-APP were aliquoted into a 96-well plate, and after attachment the medium was replaced ... |
Bioorg Med Chem Lett 18: 4232-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.05.064 BindingDB Entry DOI: 10.7270/Q26Q1VJM |
More data for this Ligand-Target Pair | |
Amyloid-beta precursor protein
(Homo sapiens (Human)) | BDBM50163996
(4-(4-Chloro-benzenesulfonyl)-4-(2-methoxy-phenyl)-...)Show SMILES CCOC(=O)N1CCC(CC1)(c1ccccc1OC)S(=O)(=O)c1ccc(Cl)cc1 Show InChI InChI=1S/C21H24ClNO5S/c1-3-28-20(24)23-14-12-21(13-15-23,18-6-4-5-7-19(18)27-2)29(25,26)17-10-8-16(22)9-11-17/h4-11H,3,12-15H2,1-2H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 1.03E+3 | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description In vitro inhibition of amyloid precursor protein 695 activity in CHO cells expressing human APP |
Bioorg Med Chem Lett 15: 1891-4 (2005)
Article DOI: 10.1016/j.bmcl.2005.02.006 BindingDB Entry DOI: 10.7270/Q2N879B4 |
More data for this Ligand-Target Pair | |
Amyloid-beta precursor protein
(Homo sapiens (Human)) | BDBM28961
(CHEMBL180641 | ethyl 4-[(4-chlorobenzene)sulfonyl]...)Show SMILES CCOC(=O)N1CCC(CC1)(c1ccccc1)S(=O)(=O)c1ccc(Cl)cc1 Show InChI InChI=1S/C20H22ClNO4S/c1-2-26-19(23)22-14-12-20(13-15-22,16-6-4-3-5-7-16)27(24,25)18-10-8-17(21)9-11-18/h3-11H,2,12-15H2,1H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 2.09E+4 | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description In vitro effective concentration against beta amyloid protein 42 in ELISA |
Bioorg Med Chem Lett 15: 1891-4 (2005)
Article DOI: 10.1016/j.bmcl.2005.02.006 BindingDB Entry DOI: 10.7270/Q2N879B4 |
More data for this Ligand-Target Pair | |
Amyloid-beta precursor protein
(Homo sapiens (Human)) | BDBM50163996
(4-(4-Chloro-benzenesulfonyl)-4-(2-methoxy-phenyl)-...)Show SMILES CCOC(=O)N1CCC(CC1)(c1ccccc1OC)S(=O)(=O)c1ccc(Cl)cc1 Show InChI InChI=1S/C21H24ClNO5S/c1-3-28-20(24)23-14-12-21(13-15-23,18-6-4-5-7-19(18)27-2)29(25,26)17-10-8-16(22)9-11-17/h4-11H,3,12-15H2,1-2H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 530 | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description In vitro reduction of Swedish NL mutant amyloid precursor protein activity expressed in CHO cells |
Bioorg Med Chem Lett 15: 1891-4 (2005)
Article DOI: 10.1016/j.bmcl.2005.02.006 BindingDB Entry DOI: 10.7270/Q2N879B4 |
More data for this Ligand-Target Pair | |
Amyloid-beta precursor protein
(Homo sapiens (Human)) | BDBM50163997
(4-(4-Methoxy-benzenesulfonyl)-4-phenyl-piperidine-...)Show SMILES CCOC(=O)N1CCC(CC1)(c1ccccc1)S(=O)(=O)c1ccc(OC)cc1 Show InChI InChI=1S/C21H25NO5S/c1-3-27-20(23)22-15-13-21(14-16-22,17-7-5-4-6-8-17)28(24,25)19-11-9-18(26-2)10-12-19/h4-12H,3,13-16H2,1-2H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 9.70E+4 | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description In vitro effective concentration against beta amyloid protein 40 in ELISA |
Bioorg Med Chem Lett 15: 1891-4 (2005)
Article DOI: 10.1016/j.bmcl.2005.02.006 BindingDB Entry DOI: 10.7270/Q2N879B4 |
More data for this Ligand-Target Pair | |
Amyloid-beta precursor protein
(Homo sapiens (Human)) | BDBM50163996
(4-(4-Chloro-benzenesulfonyl)-4-(2-methoxy-phenyl)-...)Show SMILES CCOC(=O)N1CCC(CC1)(c1ccccc1OC)S(=O)(=O)c1ccc(Cl)cc1 Show InChI InChI=1S/C21H24ClNO5S/c1-3-28-20(24)23-14-12-21(13-15-23,18-6-4-5-7-19(18)27-2)29(25,26)17-10-8-16(22)9-11-17/h4-11H,3,12-15H2,1-2H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 5.00E+3 | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description In vitro effective concentration against beta amyloid protein 42 in ELISA |
Bioorg Med Chem Lett 15: 1891-4 (2005)
Article DOI: 10.1016/j.bmcl.2005.02.006 BindingDB Entry DOI: 10.7270/Q2N879B4 |
More data for this Ligand-Target Pair | |
Amyloid-beta precursor protein
(Homo sapiens (Human)) | BDBM28960
((2R)-2-{[5-chloro-2-(hydroxymethyl)phenyl](4-chlor...)Show SMILES CCCNC(=O)OC[C@@H](C)N(c1cc(Cl)ccc1CO)S(=O)(=O)c1ccc(Cl)cc1 |r| Show InChI InChI=1S/C20H24Cl2N2O5S/c1-3-10-23-20(26)29-13-14(2)24(19-11-17(22)5-4-15(19)12-25)30(27,28)18-8-6-16(21)7-9-18/h4-9,11,14,25H,3,10,12-13H2,1-2H3,(H,23,26)/t14-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 100 | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description In vitro effective concentration against beta amyloid protein 40 in ELISA |
Bioorg Med Chem Lett 15: 1891-4 (2005)
Article DOI: 10.1016/j.bmcl.2005.02.006 BindingDB Entry DOI: 10.7270/Q2N879B4 |
More data for this Ligand-Target Pair | |
Amyloid-beta precursor protein
(Homo sapiens (Human)) | BDBM50163998
(4-(4-Methoxy-benzenesulfonyl)-4-o-tolyl-piperidine...)Show SMILES CCOC(=O)N1CCC(CC1)(c1ccccc1C)S(=O)(=O)c1ccc(OC)cc1 Show InChI InChI=1S/C22H27NO5S/c1-4-28-21(24)23-15-13-22(14-16-23,20-8-6-5-7-17(20)2)29(25,26)19-11-9-18(27-3)10-12-19/h5-12H,4,13-16H2,1-3H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 2.45E+4 | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description In vitro effective concentration against beta amyloid protein 40 in ELISA |
Bioorg Med Chem Lett 15: 1891-4 (2005)
Article DOI: 10.1016/j.bmcl.2005.02.006 BindingDB Entry DOI: 10.7270/Q2N879B4 |
More data for this Ligand-Target Pair | |
Amyloid-beta precursor protein
(Homo sapiens (Human)) | BDBM50163999
(4-(4-Chloro-benzenesulfonyl)-4-o-tolyl-piperidine-...)Show SMILES CCOC(=O)N1CCC(CC1)(c1ccccc1C)S(=O)(=O)c1ccc(Cl)cc1 Show InChI InChI=1S/C21H24ClNO4S/c1-3-27-20(24)23-14-12-21(13-15-23,19-7-5-4-6-16(19)2)28(25,26)18-10-8-17(22)9-11-18/h4-11H,3,12-15H2,1-2H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 3.70E+3 | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description In vitro effective concentration against beta amyloid protein 42 in ELISA |
Bioorg Med Chem Lett 15: 1891-4 (2005)
Article DOI: 10.1016/j.bmcl.2005.02.006 BindingDB Entry DOI: 10.7270/Q2N879B4 |
More data for this Ligand-Target Pair | |
Amyloid-beta precursor protein
(Homo sapiens (Human)) | BDBM50164000
(4-(4-Methoxy-benzenesulfonyl)-4-(2-methoxy-phenyl)...)Show SMILES CCOC(=O)N1CCC(CC1)(c1ccccc1OC)S(=O)(=O)c1ccc(OC)cc1 Show InChI InChI=1S/C22H27NO6S/c1-4-29-21(24)23-15-13-22(14-16-23,19-7-5-6-8-20(19)28-3)30(25,26)18-11-9-17(27-2)10-12-18/h5-12H,4,13-16H2,1-3H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 5.06E+4 | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description In vitro effective concentration against beta amyloid protein 40 in ELISA |
Bioorg Med Chem Lett 15: 1891-4 (2005)
Article DOI: 10.1016/j.bmcl.2005.02.006 BindingDB Entry DOI: 10.7270/Q2N879B4 |
More data for this Ligand-Target Pair | |
Amyloid-beta precursor protein
(Homo sapiens (Human)) | BDBM50163996
(4-(4-Chloro-benzenesulfonyl)-4-(2-methoxy-phenyl)-...)Show SMILES CCOC(=O)N1CCC(CC1)(c1ccccc1OC)S(=O)(=O)c1ccc(Cl)cc1 Show InChI InChI=1S/C21H24ClNO5S/c1-3-28-20(24)23-14-12-21(13-15-23,18-6-4-5-7-19(18)27-2)29(25,26)17-10-8-16(22)9-11-17/h4-11H,3,12-15H2,1-2H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 3.50E+3 | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description In vitro effective concentration against beta amyloid protein 40 in ELISA |
Bioorg Med Chem Lett 15: 1891-4 (2005)
Article DOI: 10.1016/j.bmcl.2005.02.006 BindingDB Entry DOI: 10.7270/Q2N879B4 |
More data for this Ligand-Target Pair | |
Amyloid-beta precursor protein
(Homo sapiens (Human)) | BDBM28961
(CHEMBL180641 | ethyl 4-[(4-chlorobenzene)sulfonyl]...)Show SMILES CCOC(=O)N1CCC(CC1)(c1ccccc1)S(=O)(=O)c1ccc(Cl)cc1 Show InChI InChI=1S/C20H22ClNO4S/c1-2-26-19(23)22-14-12-20(13-15-22,16-6-4-3-5-7-16)27(24,25)18-10-8-17(21)9-11-18/h3-11H,2,12-15H2,1H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 1.22E+4 | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description In vitro effective concentration against beta amyloid protein 40 in ELISA |
Bioorg Med Chem Lett 15: 1891-4 (2005)
Article DOI: 10.1016/j.bmcl.2005.02.006 BindingDB Entry DOI: 10.7270/Q2N879B4 |
More data for this Ligand-Target Pair | |
Amyloid-beta precursor protein
(Homo sapiens (Human)) | BDBM50163999
(4-(4-Chloro-benzenesulfonyl)-4-o-tolyl-piperidine-...)Show SMILES CCOC(=O)N1CCC(CC1)(c1ccccc1C)S(=O)(=O)c1ccc(Cl)cc1 Show InChI InChI=1S/C21H24ClNO4S/c1-3-27-20(24)23-14-12-21(13-15-23,19-7-5-4-6-16(19)2)28(25,26)18-10-8-17(22)9-11-18/h4-11H,3,12-15H2,1-2H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 2.70E+3 | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description In vitro effective concentration against beta amyloid protein 40 in ELISA |
Bioorg Med Chem Lett 15: 1891-4 (2005)
Article DOI: 10.1016/j.bmcl.2005.02.006 BindingDB Entry DOI: 10.7270/Q2N879B4 |
More data for this Ligand-Target Pair | |
Amyloid-beta precursor protein
(Homo sapiens (Human)) | BDBM50163996
(4-(4-Chloro-benzenesulfonyl)-4-(2-methoxy-phenyl)-...)Show SMILES CCOC(=O)N1CCC(CC1)(c1ccccc1OC)S(=O)(=O)c1ccc(Cl)cc1 Show InChI InChI=1S/C21H24ClNO5S/c1-3-28-20(24)23-14-12-21(13-15-23,18-6-4-5-7-19(18)27-2)29(25,26)17-10-8-16(22)9-11-17/h4-11H,3,12-15H2,1-2H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 640 | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description In vitro elevation of beta C-terminal fragment (Ct-99) in CHO cells expressing mutant Swedish NL human APP |
Bioorg Med Chem Lett 15: 1891-4 (2005)
Article DOI: 10.1016/j.bmcl.2005.02.006 BindingDB Entry DOI: 10.7270/Q2N879B4 |
More data for this Ligand-Target Pair | |
Amyloid-beta precursor protein
(Homo sapiens (Human)) | BDBM50164001
(4-Benzenesulfonyl-4-o-tolyl-piperidine-1-carboxyli...)Show SMILES CCOC(=O)N1CCC(CC1)(c1ccccc1C)S(=O)(=O)c1ccccc1 Show InChI InChI=1S/C21H25NO4S/c1-3-26-20(23)22-15-13-21(14-16-22,19-12-8-7-9-17(19)2)27(24,25)18-10-5-4-6-11-18/h4-12H,3,13-16H2,1-2H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 4.86E+4 | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description In vitro effective concentration against beta amyloid protein 40 in ELISA |
Bioorg Med Chem Lett 15: 1891-4 (2005)
Article DOI: 10.1016/j.bmcl.2005.02.006 BindingDB Entry DOI: 10.7270/Q2N879B4 |
More data for this Ligand-Target Pair | |
Amyloid-beta precursor protein
(Homo sapiens (Human)) | BDBM50164002
(4-Benzenesulfonyl-4-(2-methoxy-phenyl)-piperidine-...)Show SMILES CCOC(=O)N1CCC(CC1)(c1ccccc1OC)S(=O)(=O)c1ccccc1 Show InChI InChI=1S/C21H25NO5S/c1-3-27-20(23)22-15-13-21(14-16-22,18-11-7-8-12-19(18)26-2)28(24,25)17-9-5-4-6-10-17/h4-12H,3,13-16H2,1-2H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 6.27E+4 | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description In vitro effective concentration against beta amyloid protein 40 in ELISA |
Bioorg Med Chem Lett 15: 1891-4 (2005)
Article DOI: 10.1016/j.bmcl.2005.02.006 BindingDB Entry DOI: 10.7270/Q2N879B4 |
More data for this Ligand-Target Pair | |
Gamma-secretase subunit APH-1A/Gamma-secretase subunit PEN-2/Nicastrin [34-709]/Presenilin-1
(Homo sapiens (Human)) | BDBM28947
((2S,3S)-2-{[(4-chlorophenyl)methyl]amino}-3-methyl...)Show InChI InChI=1S/C13H20ClNO/c1-3-10(2)13(9-16)15-8-11-4-6-12(14)7-5-11/h4-7,10,13,15-16H,3,8-9H2,1-2H3/t10-,13+/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a |
Wyeth Research
| Assay Description A Chinese Hamster Ovary cell line stably expressing human beta-APP were aliquoted into a 96-well plate, and after attachment the medium was replaced ... |
Bioorg Med Chem Lett 18: 4232-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.05.064 BindingDB Entry DOI: 10.7270/Q26Q1VJM |
More data for this Ligand-Target Pair | |
Gamma-secretase subunit APH-1A/Gamma-secretase subunit PEN-2/Nicastrin [34-709]/Presenilin-1
(Homo sapiens (Human)) | BDBM28949
(1-(4-chlorophenyl)-3-[(2S,3S)-1-hydroxy-3-methylpe...)Show SMILES CC[C@H](C)[C@@H](CO)NC(=O)Nc1ccc(Cl)cc1 |r| Show InChI InChI=1S/C13H19ClN2O2/c1-3-9(2)12(8-17)16-13(18)15-11-6-4-10(14)5-7-11/h4-7,9,12,17H,3,8H2,1-2H3,(H2,15,16,18)/t9-,12+/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | n/a | 4.73E+4 | n/a | n/a | n/a | n/a |
Wyeth Research
| Assay Description A Chinese Hamster Ovary cell line stably expressing human beta-APP were aliquoted into a 96-well plate, and after attachment the medium was replaced ... |
Bioorg Med Chem Lett 18: 4232-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.05.064 BindingDB Entry DOI: 10.7270/Q26Q1VJM |
More data for this Ligand-Target Pair | |
Gamma-secretase subunit APH-1A/Gamma-secretase subunit PEN-2/Nicastrin [34-709]/Presenilin-1
(Homo sapiens (Human)) | BDBM28951
((2S)-N-(4-chlorophenyl)-1-hydroxybutane-2-sulfonam...)Show InChI InChI=1S/C10H14ClNO3S/c1-2-9(7-13)12-16(14,15)10-5-3-8(11)4-6-10/h3-6,9,12-13H,2,7H2,1H3/t9-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| Purchase
PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a |
Wyeth Research
| Assay Description A Chinese Hamster Ovary cell line stably expressing human beta-APP were aliquoted into a 96-well plate, and after attachment the medium was replaced ... |
Bioorg Med Chem Lett 18: 4232-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.05.064 BindingDB Entry DOI: 10.7270/Q26Q1VJM |
More data for this Ligand-Target Pair | |
Gamma-secretase subunit APH-1A/Gamma-secretase subunit PEN-2/Nicastrin [34-709]/Presenilin-1
(Homo sapiens (Human)) | BDBM28953
((2S)-N-(4-chlorophenyl)-1-hydroxy-3,3-dimethylbuta...)Show SMILES CC(C)(C)[C@@H](CO)NS(=O)(=O)c1ccc(Cl)cc1 |r| Show InChI InChI=1S/C12H18ClNO3S/c1-12(2,3)11(8-15)14-18(16,17)10-6-4-9(13)5-7-10/h4-7,11,14-15H,8H2,1-3H3/t11-/m1/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| Purchase
PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 2.91E+4 | n/a | n/a | n/a | n/a |
Wyeth Research
| Assay Description A Chinese Hamster Ovary cell line stably expressing human beta-APP were aliquoted into a 96-well plate, and after attachment the medium was replaced ... |
Bioorg Med Chem Lett 18: 4232-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.05.064 BindingDB Entry DOI: 10.7270/Q26Q1VJM |
More data for this Ligand-Target Pair | |