Found 27 hits with Last Name = 'sutton' and Initial = 'k' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM86054
(5'-IODORESINIFERATOXIN | I-RTX)Show SMILES COc1cc(CC(=O)OCC2=CC[C@H]3[C@@H](C=C(C)C3=O)[C@]34O[C@]5(Cc6ccccc6)O[C@H]([C@H]23)[C@](C[C@H]4C)(O5)C(C)=C)cc(I)c1O |t:10,15,THB:37:22:32:35.34.33,23:22:32:35.34.33| Show InChI InChI=1S/C37H39IO8/c1-20(2)35-17-22(4)37-27-13-21(3)32(40)26(27)12-11-25(19-43-30(39)16-24-14-28(38)33(41)29(15-24)42-5)31(37)34(35)44-36(45-35,46-37)18-23-9-7-6-8-10-23/h6-11,13-15,22,26-27,31,34,41H,1,12,16-19H2,2-5H3/t22-,26+,27-,31+,34-,35-,36-,37+/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| 0.390 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp and Dohme
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 303: 1052-60 (2002)
Article DOI: 10.1124/jpet.102.040394 BindingDB Entry DOI: 10.7270/Q279437S |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM86054
(5'-IODORESINIFERATOXIN | I-RTX)Show SMILES COc1cc(CC(=O)OCC2=CC[C@H]3[C@@H](C=C(C)C3=O)[C@]34O[C@]5(Cc6ccccc6)O[C@H]([C@H]23)[C@](C[C@H]4C)(O5)C(C)=C)cc(I)c1O |t:10,15,THB:37:22:32:35.34.33,23:22:32:35.34.33| Show InChI InChI=1S/C37H39IO8/c1-20(2)35-17-22(4)37-27-13-21(3)32(40)26(27)12-11-25(19-43-30(39)16-24-14-28(38)33(41)29(15-24)42-5)31(37)34(35)44-36(45-35,46-37)18-23-9-7-6-8-10-23/h6-11,13-15,22,26-27,31,34,41H,1,12,16-19H2,2-5H3/t22-,26+,27-,31+,34-,35-,36-,37+/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| 6.70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp and Dohme
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 303: 1052-60 (2002)
Article DOI: 10.1124/jpet.102.040394 BindingDB Entry DOI: 10.7270/Q279437S |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM20284
(CHEMBL391997 | CPZ | Capsazepine | N-[2-(4-chlorop...)Show InChI InChI=1S/C19H21ClN2O2S/c20-16-5-3-13(4-6-16)7-8-21-19(25)22-9-1-2-14-10-17(23)18(24)11-15(14)12-22/h3-6,10-11,23-24H,1-2,7-9,12H2,(H,21,25) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid PDB UniChem
Patents
Similars
| PDB Article PubMed
| 4.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp and Dohme
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 303: 1052-60 (2002)
Article DOI: 10.1124/jpet.102.040394 BindingDB Entry DOI: 10.7270/Q279437S |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50184737
(CHEMBL378563 | N-(4-(trifluoromethyl)phenyl)-4-(3-...)Show SMILES FC(F)(F)c1ccc(NC(=O)c2ccc(cc2)-c2ncccc2C(F)(F)F)cc1 Show InChI InChI=1S/C20H12F6N2O/c21-19(22,23)14-7-9-15(10-8-14)28-18(29)13-5-3-12(4-6-13)17-16(20(24,25)26)2-1-11-27-17/h1-11H,(H,28,29) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | 5.5 | n/a |
Merck Sharp & Dohme
Curated by ChEMBL
| Assay Description Inhibition of acidic pH 5.5-stimulated current in CHO cells expressing human TRPV1 receptor by patch clamp |
Bioorg Med Chem Lett 16: 2872-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.03.004 BindingDB Entry DOI: 10.7270/Q2959H50 |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50184729
(2-(4-(trifluoromethyl)phenyl)-6-(3-(trifluoromethy...)Show SMILES FC(F)(F)c1ccc(cc1)-n1[nH]c2cc(ccc2c1=O)-c1ncccc1C(F)(F)F Show InChI InChI=1S/C20H11F6N3O/c21-19(22,23)12-4-6-13(7-5-12)29-18(30)14-8-3-11(10-16(14)28-29)17-15(20(24,25)26)2-1-9-27-17/h1-10,28H | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | 5.5 | n/a |
Merck Sharp & Dohme
Curated by ChEMBL
| Assay Description Inhibition of acidic pH 5.5-stimulated current in CHO cells expressing human TRPV1 receptor by patch clamp |
Bioorg Med Chem Lett 16: 2872-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.03.004 BindingDB Entry DOI: 10.7270/Q2959H50 |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50184737
(CHEMBL378563 | N-(4-(trifluoromethyl)phenyl)-4-(3-...)Show SMILES FC(F)(F)c1ccc(NC(=O)c2ccc(cc2)-c2ncccc2C(F)(F)F)cc1 Show InChI InChI=1S/C20H12F6N2O/c21-19(22,23)14-7-9-15(10-8-14)28-18(29)13-5-3-12(4-6-13)17-16(20(24,25)26)2-1-11-27-17/h1-11H,(H,28,29) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme
Curated by ChEMBL
| Assay Description Antagonist activity against capsaicin-induced intracellular calcium ion increase in CHO cells expressing human TRPV1 in FLIPR assay |
Bioorg Med Chem Lett 16: 2872-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.03.004 BindingDB Entry DOI: 10.7270/Q2959H50 |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50184738
(2-(4-(trifluoromethyl)phenyl)-6-(3-(trifluoromethy...)Show SMILES FC(F)(F)c1ccc(cc1)-c1nc2cc(ccc2[nH]1)-c1ncccc1C(F)(F)F Show InChI InChI=1S/C20H11F6N3/c21-19(22,23)13-6-3-11(4-7-13)18-28-15-8-5-12(10-16(15)29-18)17-14(20(24,25)26)2-1-9-27-17/h1-10H,(H,28,29) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 22 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme
Curated by ChEMBL
| Assay Description Antagonist activity against capsaicin-induced intracellular calcium ion increase in CHO cells expressing human TRPV1 in FLIPR assay |
Bioorg Med Chem Lett 16: 2872-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.03.004 BindingDB Entry DOI: 10.7270/Q2959H50 |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50184730
(4-(trifluoromethyl)-N-(4-(3-(trifluoromethyl)pyrid...)Show SMILES FC(F)(F)c1ccc(cc1)C(=O)Nc1ccc(cc1)-c1ncccc1C(F)(F)F Show InChI InChI=1S/C20H12F6N2O/c21-19(22,23)14-7-3-13(4-8-14)18(29)28-15-9-5-12(6-10-15)17-16(20(24,25)26)2-1-11-27-17/h1-11H,(H,28,29) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 24 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme
Curated by ChEMBL
| Assay Description Antagonist activity against capsaicin-induced intracellular calcium ion increase in CHO cells expressing human TRPV1 in FLIPR assay |
Bioorg Med Chem Lett 16: 2872-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.03.004 BindingDB Entry DOI: 10.7270/Q2959H50 |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50184730
(4-(trifluoromethyl)-N-(4-(3-(trifluoromethyl)pyrid...)Show SMILES FC(F)(F)c1ccc(cc1)C(=O)Nc1ccc(cc1)-c1ncccc1C(F)(F)F Show InChI InChI=1S/C20H12F6N2O/c21-19(22,23)14-7-3-13(4-8-14)18(29)28-15-9-5-12(6-10-15)17-16(20(24,25)26)2-1-11-27-17/h1-11H,(H,28,29) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 33 | n/a | n/a | n/a | n/a | 5.5 | n/a |
Merck Sharp & Dohme
Curated by ChEMBL
| Assay Description Inhibition of acidic pH 5.5-stimulated current in CHO cells expressing human TRPV1 receptor by patch clamp |
Bioorg Med Chem Lett 16: 2872-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.03.004 BindingDB Entry DOI: 10.7270/Q2959H50 |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50184729
(2-(4-(trifluoromethyl)phenyl)-6-(3-(trifluoromethy...)Show SMILES FC(F)(F)c1ccc(cc1)-n1[nH]c2cc(ccc2c1=O)-c1ncccc1C(F)(F)F Show InChI InChI=1S/C20H11F6N3O/c21-19(22,23)12-4-6-13(7-5-12)29-18(30)14-8-3-11(10-16(14)28-29)17-15(20(24,25)26)2-1-9-27-17/h1-10,28H | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 35 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme
Curated by ChEMBL
| Assay Description Antagonist activity against capsaicin-induced intracellular calcium ion increase in CHO cells expressing human TRPV1 in FLIPR assay |
Bioorg Med Chem Lett 16: 2872-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.03.004 BindingDB Entry DOI: 10.7270/Q2959H50 |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50184745
(CHEMBL209124 | N-(4-(3-methylpyridin-2-yl)phenyl)-...)Show SMILES Cc1cccnc1-c1ccc(NC(=O)c2ccc(cc2)C(F)(F)F)cc1 Show InChI InChI=1S/C20H15F3N2O/c1-13-3-2-12-24-18(13)14-6-10-17(11-7-14)25-19(26)15-4-8-16(9-5-15)20(21,22)23/h2-12H,1H3,(H,25,26) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 160 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme
Curated by ChEMBL
| Assay Description Antagonist activity against capsaicin-induced intracellular calcium ion increase in CHO cells expressing human TRPV1 in FLIPR assay |
Bioorg Med Chem Lett 16: 2872-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.03.004 BindingDB Entry DOI: 10.7270/Q2959H50 |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50184735
(2-p-tolyl-6-(3-(trifluoromethyl)pyridin-2-yl)-1H-b...)Show SMILES Cc1ccc(cc1)-c1nc2cc(ccc2[nH]1)-c1ncccc1C(F)(F)F Show InChI InChI=1S/C20H14F3N3/c1-12-4-6-13(7-5-12)19-25-16-9-8-14(11-17(16)26-19)18-15(20(21,22)23)3-2-10-24-18/h2-11H,1H3,(H,25,26) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 170 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme
Curated by ChEMBL
| Assay Description Antagonist activity against capsaicin-induced intracellular calcium ion increase in CHO cells expressing human TRPV1 in FLIPR assay |
Bioorg Med Chem Lett 16: 2872-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.03.004 BindingDB Entry DOI: 10.7270/Q2959H50 |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50184731
(6-(2-methoxyphenyl)-2-(4-(trifluoromethyl)phenyl)-...)Show SMILES COc1ccccc1-c1ccc2c(c1)[nH]n(-c1ccc(cc1)C(F)(F)F)c2=O Show InChI InChI=1S/C21H15F3N2O2/c1-28-19-5-3-2-4-16(19)13-6-11-17-18(12-13)25-26(20(17)27)15-9-7-14(8-10-15)21(22,23)24/h2-12,25H,1H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 170 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme
Curated by ChEMBL
| Assay Description Antagonist activity against capsaicin-induced intracellular calcium ion increase in CHO cells expressing human TRPV1 in FLIPR assay |
Bioorg Med Chem Lett 16: 2872-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.03.004 BindingDB Entry DOI: 10.7270/Q2959H50 |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50184740
(6-(3-methylpyridin-2-yl)-2-(4-(trifluoromethyl)phe...)Show SMILES Cc1cccnc1-c1ccc2c(c1)[nH]n(-c1ccc(cc1)C(F)(F)F)c2=O Show InChI InChI=1S/C20H14F3N3O/c1-12-3-2-10-24-18(12)13-4-9-16-17(11-13)25-26(19(16)27)15-7-5-14(6-8-15)20(21,22)23/h2-11,25H,1H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 180 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme
Curated by ChEMBL
| Assay Description Antagonist activity against capsaicin-induced intracellular calcium ion increase in CHO cells expressing human TRPV1 in FLIPR assay |
Bioorg Med Chem Lett 16: 2872-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.03.004 BindingDB Entry DOI: 10.7270/Q2959H50 |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM50184729
(2-(4-(trifluoromethyl)phenyl)-6-(3-(trifluoromethy...)Show SMILES FC(F)(F)c1ccc(cc1)-n1[nH]c2cc(ccc2c1=O)-c1ncccc1C(F)(F)F Show InChI InChI=1S/C20H11F6N3O/c21-19(22,23)12-4-6-13(7-5-12)29-18(30)14-8-3-11(10-16(14)28-29)17-15(20(24,25)26)2-1-9-27-17/h1-10,28H | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 220 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme
Curated by ChEMBL
| Assay Description Activity against capsaicin-induced intracellular calcium ion increase in CHO cells expressing rat TRPV1 assessed by patch clamp |
Bioorg Med Chem Lett 16: 2872-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.03.004 BindingDB Entry DOI: 10.7270/Q2959H50 |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM50184729
(2-(4-(trifluoromethyl)phenyl)-6-(3-(trifluoromethy...)Show SMILES FC(F)(F)c1ccc(cc1)-n1[nH]c2cc(ccc2c1=O)-c1ncccc1C(F)(F)F Show InChI InChI=1S/C20H11F6N3O/c21-19(22,23)12-4-6-13(7-5-12)29-18(30)14-8-3-11(10-16(14)28-29)17-15(20(24,25)26)2-1-9-27-17/h1-10,28H | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 220 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme
Curated by ChEMBL
| Assay Description Activity against capsaicin-induced intracellular calcium ion increase in CHO cells expressing rat TRPV1 assessed by patch clamp |
Bioorg Med Chem Lett 16: 2872-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.03.004 BindingDB Entry DOI: 10.7270/Q2959H50 |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50184742
(2-(4-tert-butylphenyl)-6-(3-(trifluoromethyl)pyrid...)Show SMILES CC(C)(C)c1ccc(cc1)-c1nc2cc(ccc2[nH]1)-c1ncccc1C(F)(F)F Show InChI InChI=1S/C23H20F3N3/c1-22(2,3)16-9-6-14(7-10-16)21-28-18-11-8-15(13-19(18)29-21)20-17(23(24,25)26)5-4-12-27-20/h4-13H,1-3H3,(H,28,29) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 224 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme
Curated by ChEMBL
| Assay Description Antagonist activity against capsaicin-induced intracellular calcium ion increase in CHO cells expressing human TRPV1 in FLIPR assay |
Bioorg Med Chem Lett 16: 2872-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.03.004 BindingDB Entry DOI: 10.7270/Q2959H50 |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50184734
(6-(3-methylpyridin-2-yl)-2-(4-(trifluoromethyl)phe...)Show SMILES Cc1cccnc1-c1ccc2c(n1)[nH]n(-c1ccc(cc1)C(F)(F)F)c2=O Show InChI InChI=1S/C19H13F3N4O/c1-11-3-2-10-23-16(11)15-9-8-14-17(24-15)25-26(18(14)27)13-6-4-12(5-7-13)19(20,21)22/h2-10H,1H3,(H,24,25) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 270 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme
Curated by ChEMBL
| Assay Description Antagonist activity against capsaicin-induced intracellular calcium ion increase in CHO cells expressing human TRPV1 in FLIPR assay |
Bioorg Med Chem Lett 16: 2872-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.03.004 BindingDB Entry DOI: 10.7270/Q2959H50 |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50184739
(2-(4-(trifluoromethyl)phenyl)-6-(3-(trifluoromethy...)Show SMILES FC(F)(F)c1ccc(cc1)-n1[nH]c2NC(CCc2c1=O)c1ncccc1C(F)(F)F Show InChI InChI=1S/C19H14F6N4O/c20-18(21,22)10-3-5-11(6-4-10)29-17(30)12-7-8-14(27-16(12)28-29)15-13(19(23,24)25)2-1-9-26-15/h1-6,9,14,27-28H,7-8H2 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 290 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme
Curated by ChEMBL
| Assay Description Antagonist activity against capsaicin-induced intracellular calcium ion increase in CHO cells expressing human TRPV1 in FLIPR assay |
Bioorg Med Chem Lett 16: 2872-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.03.004 BindingDB Entry DOI: 10.7270/Q2959H50 |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50184741
(2-(4-fluorophenyl)-6-(3-(trifluoromethyl)pyridin-2...)Show SMILES Fc1ccc(cc1)-c1nc2cc(ccc2[nH]1)-c1ncccc1C(F)(F)F Show InChI InChI=1S/C19H11F4N3/c20-13-6-3-11(4-7-13)18-25-15-8-5-12(10-16(15)26-18)17-14(19(21,22)23)2-1-9-24-17/h1-10H,(H,25,26) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 320 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme
Curated by ChEMBL
| Assay Description Antagonist activity against capsaicin-induced intracellular calcium ion increase in CHO cells expressing human TRPV1 in FLIPR assay |
Bioorg Med Chem Lett 16: 2872-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.03.004 BindingDB Entry DOI: 10.7270/Q2959H50 |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50184747
(2-(4-(trifluoromethyl)phenyl)-1,2-dihydroindazol-3...)Show InChI InChI=1S/C14H9F3N2O/c15-14(16,17)9-5-7-10(8-6-9)19-13(20)11-3-1-2-4-12(11)18-19/h1-8,18H | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 340 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme
Curated by ChEMBL
| Assay Description Antagonist activity against capsaicin-induced intracellular calcium ion increase in CHO cells expressing human TRPV1 in FLIPR assay |
Bioorg Med Chem Lett 16: 2872-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.03.004 BindingDB Entry DOI: 10.7270/Q2959H50 |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50184743
(2-(4-(trifluoromethyl)phenyl)-5-(3-(trifluoromethy...)Show SMILES FC(F)(F)c1ccc(cc1)-n1[nH]c2ccc(cc2c1=O)-c1ncccc1C(F)(F)F Show InChI InChI=1S/C20H11F6N3O/c21-19(22,23)12-4-6-13(7-5-12)29-18(30)14-10-11(3-8-16(14)28-29)17-15(20(24,25)26)2-1-9-27-17/h1-10,28H | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 370 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme
Curated by ChEMBL
| Assay Description Antagonist activity against capsaicin-induced intracellular calcium ion increase in CHO cells expressing human TRPV1 in FLIPR assay |
Bioorg Med Chem Lett 16: 2872-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.03.004 BindingDB Entry DOI: 10.7270/Q2959H50 |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50184746
(4-tert-butyl-N-(4-(3-(trifluoromethyl)pyridin-2-yl...)Show SMILES CC(C)(C)c1ccc(cc1)C(=O)Nc1ccc(cc1)-c1ncccc1C(F)(F)F Show InChI InChI=1S/C23H21F3N2O/c1-22(2,3)17-10-6-16(7-11-17)21(29)28-18-12-8-15(9-13-18)20-19(23(24,25)26)5-4-14-27-20/h4-14H,1-3H3,(H,28,29) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 470 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme
Curated by ChEMBL
| Assay Description Antagonist activity against capsaicin-induced intracellular calcium ion increase in CHO cells expressing human TRPV1 in FLIPR assay |
Bioorg Med Chem Lett 16: 2872-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.03.004 BindingDB Entry DOI: 10.7270/Q2959H50 |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50184733
(CHEMBL210667 | N-(4-(3-methylpyridin-2-yl)phenyl)-...)Show SMILES Cc1cccnc1-c1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1 Show InChI InChI=1S/C20H15F3N2O/c1-13-4-3-11-24-18(13)14-7-9-17(10-8-14)25-19(26)15-5-2-6-16(12-15)20(21,22)23/h2-12H,1H3,(H,25,26) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 640 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme
Curated by ChEMBL
| Assay Description Antagonist activity against capsaicin-induced intracellular calcium ion increase in CHO cells expressing human TRPV1 in FLIPR assay |
Bioorg Med Chem Lett 16: 2872-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.03.004 BindingDB Entry DOI: 10.7270/Q2959H50 |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50184732
(4-methyl-N-(4-(3-(trifluoromethyl)pyridin-2-yl)phe...)Show SMILES Cc1ccc(cc1)C(=O)Nc1ccc(cc1)-c1ncccc1C(F)(F)F Show InChI InChI=1S/C20H15F3N2O/c1-13-4-6-15(7-5-13)19(26)25-16-10-8-14(9-11-16)18-17(20(21,22)23)3-2-12-24-18/h2-12H,1H3,(H,25,26) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme
Curated by ChEMBL
| Assay Description Antagonist activity against capsaicin-induced intracellular calcium ion increase in CHO cells expressing human TRPV1 in FLIPR assay |
Bioorg Med Chem Lett 16: 2872-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.03.004 BindingDB Entry DOI: 10.7270/Q2959H50 |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50184744
(CHEMBL209112 | N-(4-(pyridin-2-yl)phenyl)-4-(trifl...)Show SMILES FC(F)(F)c1ccc(cc1)C(=O)Nc1ccc(cc1)-c1ccccn1 Show InChI InChI=1S/C19H13F3N2O/c20-19(21,22)15-8-4-14(5-9-15)18(25)24-16-10-6-13(7-11-16)17-3-1-2-12-23-17/h1-12H,(H,24,25) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme
Curated by ChEMBL
| Assay Description Antagonist activity against capsaicin-induced intracellular calcium ion increase in CHO cells expressing human TRPV1 in FLIPR assay |
Bioorg Med Chem Lett 16: 2872-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.03.004 BindingDB Entry DOI: 10.7270/Q2959H50 |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50184736
(CHEMBL208870 | N-(4-(3-(trifluoromethyl)pyridin-2-...)Show InChI InChI=1S/C19H13F3N2O/c20-19(21,22)16-7-4-12-23-17(16)13-8-10-15(11-9-13)24-18(25)14-5-2-1-3-6-14/h1-12H,(H,24,25) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme
Curated by ChEMBL
| Assay Description Antagonist activity against capsaicin-induced intracellular calcium ion increase in CHO cells expressing human TRPV1 in FLIPR assay |
Bioorg Med Chem Lett 16: 2872-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.03.004 BindingDB Entry DOI: 10.7270/Q2959H50 |
More data for this Ligand-Target Pair | |