Found 47 hits with Last Name = 'swain' and Initial = 'ml' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Cyclin-dependent kinase 2
(Homo sapiens (Human)) | BDBM50246406
(2-fluoro-4-(5-fluoro-4-(1-isopropyl-2-methyl-1H-im...)Show SMILES CC(C)n1c(C)ncc1-c1nc(Nc2ccc(C(=O)NC3CCN(C)CC3)c(F)c2)ncc1F Show InChI InChI=1S/C24H29F2N7O/c1-14(2)33-15(3)27-13-21(33)22-20(26)12-28-24(31-22)30-17-5-6-18(19(25)11-17)23(34)29-16-7-9-32(4)10-8-16/h5-6,11-14,16H,7-10H2,1-4H3,(H,29,34)(H,28,30,31) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of CDK2 (unknown origin) |
Bioorg Med Chem Lett 18: 6369-73 (2008)
Article DOI: 10.1016/j.bmcl.2008.10.102
BindingDB Entry DOI: 10.7270/Q2XW4JNM |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 2
(Homo sapiens (Human)) | BDBM50245913
((4-(4-(1-isopropyl-2-methyl-1H-imidazol-5-yl)pyrim...)Show SMILES CN[C@H]1CCN(C1)C(=O)c1ccc(Nc2nccc(n2)-c2cnc(C)n2C(C)C)cc1 |r| Show InChI InChI=1S/C23H29N7O/c1-15(2)30-16(3)26-13-21(30)20-9-11-25-23(28-20)27-18-7-5-17(6-8-18)22(31)29-12-10-19(14-29)24-4/h5-9,11,13,15,19,24H,10,12,14H2,1-4H3,(H,25,27,28)/t19-/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of CDK2 (unknown origin) |
Bioorg Med Chem Lett 18: 6369-73 (2008)
Article DOI: 10.1016/j.bmcl.2008.10.102
BindingDB Entry DOI: 10.7270/Q2XW4JNM |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 2
(Homo sapiens (Human)) | BDBM50245865
(((S)-3-(dimethylamino)pyrrolidin-1-yl)(4-(5-fluoro...)Show SMILES CC(C)n1c(C)ncc1-c1nc(Nc2ccc(cc2)C(=O)N2CC[C@@H](C2)N(C)C)ncc1F |r| Show InChI InChI=1S/C24H30FN7O/c1-15(2)32-16(3)26-13-21(32)22-20(25)12-27-24(29-22)28-18-8-6-17(7-9-18)23(33)31-11-10-19(14-31)30(4)5/h6-9,12-13,15,19H,10-11,14H2,1-5H3,(H,27,28,29)/t19-/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
DrugBank
MMDB
PC cid
PC sid
PDB
UniChem
Similars
| MMDB
PDB
Article
PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of CDK2 (unknown origin) |
Bioorg Med Chem Lett 18: 6369-73 (2008)
Article DOI: 10.1016/j.bmcl.2008.10.102
BindingDB Entry DOI: 10.7270/Q2XW4JNM |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
Cyclin-dependent kinase 2
(Homo sapiens (Human)) | BDBM50245864
(CHEMBL462385 | N-(2-(dimethylamino)ethyl)-2-fluoro...)Show SMILES CC(C)n1c(C)ncc1-c1nc(Nc2ccc(C(=O)NCCN(C)C)c(F)c2)ncc1F Show InChI InChI=1S/C22H27F2N7O/c1-13(2)31-14(3)26-12-19(31)20-18(24)11-27-22(29-20)28-15-6-7-16(17(23)10-15)21(32)25-8-9-30(4)5/h6-7,10-13H,8-9H2,1-5H3,(H,25,32)(H,27,28,29) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of CDK2 (unknown origin) |
Bioorg Med Chem Lett 18: 6369-73 (2008)
Article DOI: 10.1016/j.bmcl.2008.10.102
BindingDB Entry DOI: 10.7270/Q2XW4JNM |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 1
(Homo sapiens (Human)) | BDBM50246408
((4-(5-fluoro-4-(1-isopropyl-2-methyl-1H-imidazol-5...)Show SMILES CN[C@H]1CCN(C1)C(=O)c1ccc(Nc2ncc(F)c(n2)-c2cnc(C)n2C(C)C)cc1 |r| Show InChI InChI=1S/C23H28FN7O/c1-14(2)31-15(3)26-12-20(31)21-19(24)11-27-23(29-21)28-17-7-5-16(6-8-17)22(32)30-10-9-18(13-30)25-4/h5-8,11-12,14,18,25H,9-10,13H2,1-4H3,(H,27,28,29)/t18-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of CDK1 (unknown origin) |
Bioorg Med Chem Lett 18: 6369-73 (2008)
Article DOI: 10.1016/j.bmcl.2008.10.102
BindingDB Entry DOI: 10.7270/Q2XW4JNM |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 2
(Homo sapiens (Human)) | BDBM50246408
((4-(5-fluoro-4-(1-isopropyl-2-methyl-1H-imidazol-5...)Show SMILES CN[C@H]1CCN(C1)C(=O)c1ccc(Nc2ncc(F)c(n2)-c2cnc(C)n2C(C)C)cc1 |r| Show InChI InChI=1S/C23H28FN7O/c1-14(2)31-15(3)26-12-20(31)21-19(24)11-27-23(29-21)28-17-7-5-16(6-8-17)22(32)30-10-9-18(13-30)25-4/h5-8,11-12,14,18,25H,9-10,13H2,1-4H3,(H,27,28,29)/t18-/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of CDK2 (unknown origin) |
Bioorg Med Chem Lett 18: 6369-73 (2008)
Article DOI: 10.1016/j.bmcl.2008.10.102
BindingDB Entry DOI: 10.7270/Q2XW4JNM |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 2
(Homo sapiens (Human)) | BDBM50245910
((4-(5-fluoro-4-(1-isopropyl-2-methyl-1H-imidazol-5...)Show SMILES CC(C)n1c(C)ncc1-c1nc(Nc2ccc(cc2)C(=O)N2CCCN(C)CC2)ncc1F Show InChI InChI=1S/C24H30FN7O/c1-16(2)32-17(3)26-15-21(32)22-20(25)14-27-24(29-22)28-19-8-6-18(7-9-19)23(33)31-11-5-10-30(4)12-13-31/h6-9,14-16H,5,10-13H2,1-4H3,(H,27,28,29) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of CDK2 (unknown origin) |
Bioorg Med Chem Lett 18: 6369-73 (2008)
Article DOI: 10.1016/j.bmcl.2008.10.102
BindingDB Entry DOI: 10.7270/Q2XW4JNM |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 2
(Homo sapiens (Human)) | BDBM50246407
(CHEMBL453629 | N-(2-(dimethylamino)ethyl)-2-fluoro...)Show SMILES CC(C)n1c(C)ncc1-c1ccnc(Nc2ccc(C(=O)NCCN(C)C)c(F)c2)n1 Show InChI InChI=1S/C22H28FN7O/c1-14(2)30-15(3)26-13-20(30)19-8-9-25-22(28-19)27-16-6-7-17(18(23)12-16)21(31)24-10-11-29(4)5/h6-9,12-14H,10-11H2,1-5H3,(H,24,31)(H,25,27,28) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of CDK2 (unknown origin) |
Bioorg Med Chem Lett 18: 6369-73 (2008)
Article DOI: 10.1016/j.bmcl.2008.10.102
BindingDB Entry DOI: 10.7270/Q2XW4JNM |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 2
(Homo sapiens (Human)) | BDBM50245911
((4-(4-(1-isopropyl-2-methyl-1H-imidazol-5-yl)pyrim...)Show SMILES CCCN(C)[C@H]1CCN(C1)C(=O)c1ccc(Nc2nccc(n2)-c2cnc(C)n2C(C)C)cc1 |r| Show InChI InChI=1S/C26H35N7O/c1-6-14-31(5)22-12-15-32(17-22)25(34)20-7-9-21(10-8-20)29-26-27-13-11-23(30-26)24-16-28-19(4)33(24)18(2)3/h7-11,13,16,18,22H,6,12,14-15,17H2,1-5H3,(H,27,29,30)/t22-/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of CDK2 (unknown origin) |
Bioorg Med Chem Lett 18: 6369-73 (2008)
Article DOI: 10.1016/j.bmcl.2008.10.102
BindingDB Entry DOI: 10.7270/Q2XW4JNM |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 1
(Homo sapiens (Human)) | BDBM50245910
((4-(5-fluoro-4-(1-isopropyl-2-methyl-1H-imidazol-5...)Show SMILES CC(C)n1c(C)ncc1-c1nc(Nc2ccc(cc2)C(=O)N2CCCN(C)CC2)ncc1F Show InChI InChI=1S/C24H30FN7O/c1-16(2)32-17(3)26-15-21(32)22-20(25)14-27-24(29-22)28-19-8-6-18(7-9-19)23(33)31-11-5-10-30(4)12-13-31/h6-9,14-16H,5,10-13H2,1-4H3,(H,27,28,29) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of CDK1 (unknown origin) |
Bioorg Med Chem Lett 18: 6369-73 (2008)
Article DOI: 10.1016/j.bmcl.2008.10.102
BindingDB Entry DOI: 10.7270/Q2XW4JNM |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 2
(Homo sapiens (Human)) | BDBM50246253
(4-(1-isopropyl-2-methyl-1H-imidazol-5-yl)-N-(4-(me...)Show SMILES CC(C)n1c(C)ncc1-c1ccnc(Nc2ccc(cc2)S(C)(=O)=O)n1 Show InChI InChI=1S/C18H21N5O2S/c1-12(2)23-13(3)20-11-17(23)16-9-10-19-18(22-16)21-14-5-7-15(8-6-14)26(4,24)25/h5-12H,1-4H3,(H,19,21,22) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
PDB
UniChem
Similars
| Article
PubMed
| n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of CDK2 (unknown origin) |
Bioorg Med Chem Lett 18: 6369-73 (2008)
Article DOI: 10.1016/j.bmcl.2008.10.102
BindingDB Entry DOI: 10.7270/Q2XW4JNM |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 2
(Homo sapiens (Human)) | BDBM50245866
(((R)-3-(dimethylamino)pyrrolidin-1-yl)(4-(5-fluoro...)Show SMILES CC(C)n1c(C)ncc1-c1nc(Nc2ccc(cc2)C(=O)N2CC[C@H](C2)N(C)C)ncc1F |r| Show InChI InChI=1S/C24H30FN7O/c1-15(2)32-16(3)26-13-21(32)22-20(25)12-27-24(29-22)28-18-8-6-17(7-9-18)23(33)31-11-10-19(14-31)30(4)5/h6-9,12-13,15,19H,10-11,14H2,1-5H3,(H,27,28,29)/t19-/m1/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of CDK2 (unknown origin) |
Bioorg Med Chem Lett 18: 6369-73 (2008)
Article DOI: 10.1016/j.bmcl.2008.10.102
BindingDB Entry DOI: 10.7270/Q2XW4JNM |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 2
(Homo sapiens (Human)) | BDBM50246357
((4-(4-(1-isopropyl-2-methyl-1H-imidazol-5-yl)pyrim...)Show SMILES CC(C)n1c(C)ncc1-c1ccnc(Nc2ccc(cc2)C(=O)N2CCN(C)CC2)n1 Show InChI InChI=1S/C23H29N7O/c1-16(2)30-17(3)25-15-21(30)20-9-10-24-23(27-20)26-19-7-5-18(6-8-19)22(31)29-13-11-28(4)12-14-29/h5-10,15-16H,11-14H2,1-4H3,(H,24,26,27) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of CDK2 (unknown origin) |
Bioorg Med Chem Lett 18: 6369-73 (2008)
Article DOI: 10.1016/j.bmcl.2008.10.102
BindingDB Entry DOI: 10.7270/Q2XW4JNM |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 1
(Homo sapiens (Human)) | BDBM50245913
((4-(4-(1-isopropyl-2-methyl-1H-imidazol-5-yl)pyrim...)Show SMILES CN[C@H]1CCN(C1)C(=O)c1ccc(Nc2nccc(n2)-c2cnc(C)n2C(C)C)cc1 |r| Show InChI InChI=1S/C23H29N7O/c1-15(2)30-16(3)26-13-21(30)20-9-11-25-23(28-20)27-18-7-5-17(6-8-18)22(31)29-12-10-19(14-29)24-4/h5-9,11,13,15,19,24H,10,12,14H2,1-4H3,(H,25,27,28)/t19-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of CDK1 (unknown origin) |
Bioorg Med Chem Lett 18: 6369-73 (2008)
Article DOI: 10.1016/j.bmcl.2008.10.102
BindingDB Entry DOI: 10.7270/Q2XW4JNM |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 1
(Homo sapiens (Human)) | BDBM50245865
(((S)-3-(dimethylamino)pyrrolidin-1-yl)(4-(5-fluoro...)Show SMILES CC(C)n1c(C)ncc1-c1nc(Nc2ccc(cc2)C(=O)N2CC[C@@H](C2)N(C)C)ncc1F |r| Show InChI InChI=1S/C24H30FN7O/c1-15(2)32-16(3)26-13-21(32)22-20(25)12-27-24(29-22)28-18-8-6-17(7-9-18)23(33)31-11-10-19(14-31)30(4)5/h6-9,12-13,15,19H,10-11,14H2,1-5H3,(H,27,28,29)/t19-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
DrugBank
MMDB
PC cid
PC sid
PDB
UniChem
Similars
| Article
PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of CDK1 (unknown origin) |
Bioorg Med Chem Lett 18: 6369-73 (2008)
Article DOI: 10.1016/j.bmcl.2008.10.102
BindingDB Entry DOI: 10.7270/Q2XW4JNM |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 2
(Homo sapiens (Human)) | BDBM50246405
(2-fluoro-4-(4-(1-isopropyl-2-methyl-1H-imidazol-5-...)Show SMILES CC(C)n1c(C)ncc1-c1ccnc(Nc2ccc(C(=O)NC3CCN(C)CC3)c(F)c2)n1 Show InChI InChI=1S/C24H30FN7O/c1-15(2)32-16(3)27-14-22(32)21-7-10-26-24(30-21)29-18-5-6-19(20(25)13-18)23(33)28-17-8-11-31(4)12-9-17/h5-7,10,13-15,17H,8-9,11-12H2,1-4H3,(H,28,33)(H,26,29,30) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of CDK2 (unknown origin) |
Bioorg Med Chem Lett 18: 6369-73 (2008)
Article DOI: 10.1016/j.bmcl.2008.10.102
BindingDB Entry DOI: 10.7270/Q2XW4JNM |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 1
(Homo sapiens (Human)) | BDBM50245866
(((R)-3-(dimethylamino)pyrrolidin-1-yl)(4-(5-fluoro...)Show SMILES CC(C)n1c(C)ncc1-c1nc(Nc2ccc(cc2)C(=O)N2CC[C@H](C2)N(C)C)ncc1F |r| Show InChI InChI=1S/C24H30FN7O/c1-15(2)32-16(3)26-13-21(32)22-20(25)12-27-24(29-22)28-18-8-6-17(7-9-18)23(33)31-11-10-19(14-31)30(4)5/h6-9,12-13,15,19H,10-11,14H2,1-5H3,(H,27,28,29)/t19-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of CDK1 (unknown origin) |
Bioorg Med Chem Lett 18: 6369-73 (2008)
Article DOI: 10.1016/j.bmcl.2008.10.102
BindingDB Entry DOI: 10.7270/Q2XW4JNM |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 1
(Homo sapiens (Human)) | BDBM50246406
(2-fluoro-4-(5-fluoro-4-(1-isopropyl-2-methyl-1H-im...)Show SMILES CC(C)n1c(C)ncc1-c1nc(Nc2ccc(C(=O)NC3CCN(C)CC3)c(F)c2)ncc1F Show InChI InChI=1S/C24H29F2N7O/c1-14(2)33-15(3)27-13-21(33)22-20(26)12-28-24(31-22)30-17-5-6-18(19(25)11-17)23(34)29-16-7-9-32(4)10-8-16/h5-6,11-14,16H,7-10H2,1-4H3,(H,29,34)(H,28,30,31) | PDB
Reactome pathway
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PC sid
UniChem
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PubMed
| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of CDK1 (unknown origin) |
Bioorg Med Chem Lett 18: 6369-73 (2008)
Article DOI: 10.1016/j.bmcl.2008.10.102
BindingDB Entry DOI: 10.7270/Q2XW4JNM |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 2
(Homo sapiens (Human)) | BDBM50246358
((4-(5-fluoro-4-(1-isopropyl-2-methyl-1H-imidazol-5...)Show SMILES CC(C)n1c(C)ncc1-c1nc(Nc2ccc(cc2)C(=O)N2CCN(C)CC2)ncc1F Show InChI InChI=1S/C23H28FN7O/c1-15(2)31-16(3)25-14-20(31)21-19(24)13-26-23(28-21)27-18-7-5-17(6-8-18)22(32)30-11-9-29(4)10-12-30/h5-8,13-15H,9-12H2,1-4H3,(H,26,27,28) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
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| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 18 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of CDK2 (unknown origin) |
Bioorg Med Chem Lett 18: 6369-73 (2008)
Article DOI: 10.1016/j.bmcl.2008.10.102
BindingDB Entry DOI: 10.7270/Q2XW4JNM |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 1
(Homo sapiens (Human)) | BDBM50246407
(CHEMBL453629 | N-(2-(dimethylamino)ethyl)-2-fluoro...)Show SMILES CC(C)n1c(C)ncc1-c1ccnc(Nc2ccc(C(=O)NCCN(C)C)c(F)c2)n1 Show InChI InChI=1S/C22H28FN7O/c1-14(2)30-15(3)26-13-20(30)19-8-9-25-22(28-19)27-16-6-7-17(18(23)12-16)21(31)24-10-11-29(4)5/h6-9,12-14H,10-11H2,1-5H3,(H,24,31)(H,25,27,28) | PDB
Reactome pathway
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| n/a | n/a | 29 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of CDK1 (unknown origin) |
Bioorg Med Chem Lett 18: 6369-73 (2008)
Article DOI: 10.1016/j.bmcl.2008.10.102
BindingDB Entry DOI: 10.7270/Q2XW4JNM |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 2
(Homo sapiens (Human)) | BDBM50246404
(4-(5-fluoro-4-(1-isopropyl-2-methyl-1H-imidazol-5-...)Show SMILES CC(C)n1c(C)ncc1-c1nc(Nc2ccc(cc2)C(=O)NC2CCN(C)CC2)ncc1F Show InChI InChI=1S/C24H30FN7O/c1-15(2)32-16(3)26-14-21(32)22-20(25)13-27-24(30-22)29-18-7-5-17(6-8-18)23(33)28-19-9-11-31(4)12-10-19/h5-8,13-15,19H,9-12H2,1-4H3,(H,28,33)(H,27,29,30) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 36 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of CDK2 (unknown origin) |
Bioorg Med Chem Lett 18: 6369-73 (2008)
Article DOI: 10.1016/j.bmcl.2008.10.102
BindingDB Entry DOI: 10.7270/Q2XW4JNM |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 2
(Homo sapiens (Human)) | BDBM50246359
(4-(4-(1-isopropyl-2-methyl-1H-imidazol-5-yl)pyrimi...)Show SMILES CC(C)n1c(C)ncc1-c1ccnc(Nc2ccc(cc2)C(=O)NC2CCN(C)CC2)n1 Show InChI InChI=1S/C24H31N7O/c1-16(2)31-17(3)26-15-22(31)21-9-12-25-24(29-21)28-19-7-5-18(6-8-19)23(32)27-20-10-13-30(4)14-11-20/h5-9,12,15-16,20H,10-11,13-14H2,1-4H3,(H,27,32)(H,25,28,29) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 37 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of CDK2 (unknown origin) |
Bioorg Med Chem Lett 18: 6369-73 (2008)
Article DOI: 10.1016/j.bmcl.2008.10.102
BindingDB Entry DOI: 10.7270/Q2XW4JNM |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 1
(Homo sapiens (Human)) | BDBM50246404
(4-(5-fluoro-4-(1-isopropyl-2-methyl-1H-imidazol-5-...)Show SMILES CC(C)n1c(C)ncc1-c1nc(Nc2ccc(cc2)C(=O)NC2CCN(C)CC2)ncc1F Show InChI InChI=1S/C24H30FN7O/c1-15(2)32-16(3)26-14-21(32)22-20(25)13-27-24(30-22)29-18-7-5-17(6-8-18)23(33)28-19-9-11-31(4)12-10-19/h5-8,13-15,19H,9-12H2,1-4H3,(H,28,33)(H,27,29,30) | PDB
Reactome pathway
KEGG
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| CHEMBL
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PC sid
UniChem
Similars
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PubMed
| n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of CDK1 (unknown origin) |
Bioorg Med Chem Lett 18: 6369-73 (2008)
Article DOI: 10.1016/j.bmcl.2008.10.102
BindingDB Entry DOI: 10.7270/Q2XW4JNM |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 1
(Homo sapiens (Human)) | BDBM50246253
(4-(1-isopropyl-2-methyl-1H-imidazol-5-yl)-N-(4-(me...)Show SMILES CC(C)n1c(C)ncc1-c1ccnc(Nc2ccc(cc2)S(C)(=O)=O)n1 Show InChI InChI=1S/C18H21N5O2S/c1-12(2)23-13(3)20-11-17(23)16-9-10-19-18(22-16)21-14-5-7-15(8-6-14)26(4,24)25/h5-12H,1-4H3,(H,19,21,22) | PDB
Reactome pathway
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CHEMBL
MCE
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PDB
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| PDB
Article
PubMed
| n/a | n/a | 62 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of CDK1 (unknown origin) |
Bioorg Med Chem Lett 18: 6369-73 (2008)
Article DOI: 10.1016/j.bmcl.2008.10.102
BindingDB Entry DOI: 10.7270/Q2XW4JNM |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Angiopoietin-1 receptor
(Homo sapiens (Human)) | BDBM50311970
(1-(3-(5-(4-aminothieno[2,3-d]pyrimidin-6-yl)-1-met...)Show SMILES Cn1cnc(c1-c1cc2c(N)ncnc2s1)-c1cccc(NC(=O)Nc2cc(ccc2F)C(F)(F)F)c1 Show InChI InChI=1S/C24H17F4N7OS/c1-35-11-32-19(20(35)18-9-15-21(29)30-10-31-22(15)37-18)12-3-2-4-14(7-12)33-23(36)34-17-8-13(24(26,27)28)5-6-16(17)25/h2-11H,1H3,(H2,29,30,31)(H2,33,34,36) | PDB
MMDB
KEGG
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PC cid
PC sid
UniChem
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PubMed
| n/a | n/a | 70 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of Tie-2 phosphorylation by cell based assay |
Bioorg Med Chem Lett 19: 6670-4 (2009)
Article DOI: 10.1016/j.bmcl.2009.10.001
BindingDB Entry DOI: 10.7270/Q2FN16BJ |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 1
(Homo sapiens (Human)) | BDBM50246357
((4-(4-(1-isopropyl-2-methyl-1H-imidazol-5-yl)pyrim...)Show SMILES CC(C)n1c(C)ncc1-c1ccnc(Nc2ccc(cc2)C(=O)N2CCN(C)CC2)n1 Show InChI InChI=1S/C23H29N7O/c1-16(2)30-17(3)25-15-21(30)20-9-10-24-23(27-20)26-19-7-5-18(6-8-19)22(31)29-13-11-28(4)12-14-29/h5-10,15-16H,11-14H2,1-4H3,(H,24,26,27) | PDB
Reactome pathway
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| n/a | n/a | 71 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of CDK1 (unknown origin) |
Bioorg Med Chem Lett 18: 6369-73 (2008)
Article DOI: 10.1016/j.bmcl.2008.10.102
BindingDB Entry DOI: 10.7270/Q2XW4JNM |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 1
(Homo sapiens (Human)) | BDBM50245912
(((S)-3-(cyclopropylamino)pyrrolidin-1-yl)(4-(4-(1-...)Show SMILES CC(C)n1c(C)ncc1-c1ccnc(Nc2ccc(cc2)C(=O)N2CC[C@@H](C2)NC2CC2)n1 |r| Show InChI InChI=1S/C25H31N7O/c1-16(2)32-17(3)27-14-23(32)22-10-12-26-25(30-22)29-20-6-4-18(5-7-20)24(33)31-13-11-21(15-31)28-19-8-9-19/h4-7,10,12,14,16,19,21,28H,8-9,11,13,15H2,1-3H3,(H,26,29,30)/t21-/m0/s1 | PDB
Reactome pathway
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| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of CDK1 (unknown origin) |
Bioorg Med Chem Lett 18: 6369-73 (2008)
Article DOI: 10.1016/j.bmcl.2008.10.102
BindingDB Entry DOI: 10.7270/Q2XW4JNM |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 1
(Homo sapiens (Human)) | BDBM50245911
((4-(4-(1-isopropyl-2-methyl-1H-imidazol-5-yl)pyrim...)Show SMILES CCCN(C)[C@H]1CCN(C1)C(=O)c1ccc(Nc2nccc(n2)-c2cnc(C)n2C(C)C)cc1 |r| Show InChI InChI=1S/C26H35N7O/c1-6-14-31(5)22-12-15-32(17-22)25(34)20-7-9-21(10-8-20)29-26-27-13-11-23(30-26)24-16-28-19(4)33(24)18(2)3/h7-11,13,16,18,22H,6,12,14-15,17H2,1-5H3,(H,27,29,30)/t22-/m0/s1 | PDB
Reactome pathway
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UniChem
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PubMed
| n/a | n/a | 120 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of CDK1 (unknown origin) |
Bioorg Med Chem Lett 18: 6369-73 (2008)
Article DOI: 10.1016/j.bmcl.2008.10.102
BindingDB Entry DOI: 10.7270/Q2XW4JNM |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 1
(Homo sapiens (Human)) | BDBM50246358
((4-(5-fluoro-4-(1-isopropyl-2-methyl-1H-imidazol-5...)Show SMILES CC(C)n1c(C)ncc1-c1nc(Nc2ccc(cc2)C(=O)N2CCN(C)CC2)ncc1F Show InChI InChI=1S/C23H28FN7O/c1-15(2)31-16(3)25-14-20(31)21-19(24)13-26-23(28-21)27-18-7-5-17(6-8-18)22(32)30-11-9-29(4)10-12-30/h5-8,13-15H,9-12H2,1-4H3,(H,26,27,28) | PDB
Reactome pathway
KEGG
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PC sid
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PubMed
| n/a | n/a | 130 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of CDK1 (unknown origin) |
Bioorg Med Chem Lett 18: 6369-73 (2008)
Article DOI: 10.1016/j.bmcl.2008.10.102
BindingDB Entry DOI: 10.7270/Q2XW4JNM |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 1
(Homo sapiens (Human)) | BDBM50246405
(2-fluoro-4-(4-(1-isopropyl-2-methyl-1H-imidazol-5-...)Show SMILES CC(C)n1c(C)ncc1-c1ccnc(Nc2ccc(C(=O)NC3CCN(C)CC3)c(F)c2)n1 Show InChI InChI=1S/C24H30FN7O/c1-15(2)32-16(3)27-14-22(32)21-7-10-26-24(30-21)29-18-5-6-19(20(25)13-18)23(33)28-17-8-11-31(4)12-9-17/h5-7,10,13-15,17H,8-9,11-12H2,1-4H3,(H,28,33)(H,26,29,30) | PDB
Reactome pathway
KEGG
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UniChem
Similars
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PubMed
| n/a | n/a | 150 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of CDK1 (unknown origin) |
Bioorg Med Chem Lett 18: 6369-73 (2008)
Article DOI: 10.1016/j.bmcl.2008.10.102
BindingDB Entry DOI: 10.7270/Q2XW4JNM |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 1
(Homo sapiens (Human)) | BDBM50246359
(4-(4-(1-isopropyl-2-methyl-1H-imidazol-5-yl)pyrimi...)Show SMILES CC(C)n1c(C)ncc1-c1ccnc(Nc2ccc(cc2)C(=O)NC2CCN(C)CC2)n1 Show InChI InChI=1S/C24H31N7O/c1-16(2)31-17(3)26-15-22(31)21-9-12-25-24(29-21)28-19-7-5-18(6-8-19)23(32)27-20-10-13-30(4)14-11-20/h5-9,12,15-16,20H,10-11,13-14H2,1-4H3,(H,27,32)(H,25,28,29) | PDB
Reactome pathway
KEGG
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| CHEMBL
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PC sid
UniChem
Similars
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PubMed
| n/a | n/a | 180 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of CDK1 (unknown origin) |
Bioorg Med Chem Lett 18: 6369-73 (2008)
Article DOI: 10.1016/j.bmcl.2008.10.102
BindingDB Entry DOI: 10.7270/Q2XW4JNM |
More data for this
Ligand-Target Pair | |
Angiopoietin-1 receptor
(Homo sapiens (Human)) | BDBM50311971
(1-(3-(5-(4-aminothieno[2,3-d]pyrimidin-6-yl)-1-met...)Show SMILES Cc1cc(NC(=O)Nc2cccc(c2)-c2ncn(C)c2-c2cc3c(N)ncnc3s2)on1 Show InChI InChI=1S/C21H18N8O2S/c1-11-6-16(31-28-11)27-21(30)26-13-5-3-4-12(7-13)17-18(29(2)10-25-17)15-8-14-19(22)23-9-24-20(14)32-15/h3-10H,1-2H3,(H2,22,23,24)(H2,26,27,30) | PDB
MMDB
KEGG
UniProtKB/SwissProt
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DrugBank
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| CHEMBL
PC cid
PC sid
UniChem
Similars
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PubMed
| n/a | n/a | 340 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of Tie-2 phosphorylation by cell based assay |
Bioorg Med Chem Lett 19: 6670-4 (2009)
Article DOI: 10.1016/j.bmcl.2009.10.001
BindingDB Entry DOI: 10.7270/Q2FN16BJ |
More data for this
Ligand-Target Pair | |
Angiopoietin-1 receptor
(Homo sapiens (Human)) | BDBM50311976
((R)-2-(4-phenyl-1-((tetrahydrofuran-2-yl)methyl)-1...)Show SMILES Nc1ncnc2sc(nc12)-c1c(ncn1C[C@H]1CCCO1)-c1ccccc1 |r| Show InChI InChI=1S/C19H18N6OS/c20-17-15-18(22-10-21-17)27-19(24-15)16-14(12-5-2-1-3-6-12)23-11-25(16)9-13-7-4-8-26-13/h1-3,5-6,10-11,13H,4,7-9H2,(H2,20,21,22)/t13-/m1/s1 | PDB
MMDB
KEGG
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PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 370 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of Tie-2 phosphorylation by cell based assay |
Bioorg Med Chem Lett 19: 6670-4 (2009)
Article DOI: 10.1016/j.bmcl.2009.10.001
BindingDB Entry DOI: 10.7270/Q2FN16BJ |
More data for this
Ligand-Target Pair | |
Angiopoietin-1 receptor
(Homo sapiens (Human)) | BDBM50311977
(2-(1-(2-morpholinobenzyl)-4-phenyl-1H-imidazol-5-y...)Show SMILES Nc1ncnc2sc(nc12)-c1c(ncn1Cc1ccccc1N1CCOCC1)-c1ccccc1 Show InChI InChI=1S/C25H23N7OS/c26-23-21-24(28-15-27-23)34-25(30-21)22-20(17-6-2-1-3-7-17)29-16-32(22)14-18-8-4-5-9-19(18)31-10-12-33-13-11-31/h1-9,15-16H,10-14H2,(H2,26,27,28) | PDB
MMDB
KEGG
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PC cid
PC sid
UniChem
Similars
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PubMed
| n/a | n/a | 440 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of Tie-2 phosphorylation by cell based assay |
Bioorg Med Chem Lett 19: 6670-4 (2009)
Article DOI: 10.1016/j.bmcl.2009.10.001
BindingDB Entry DOI: 10.7270/Q2FN16BJ |
More data for this
Ligand-Target Pair | |
Angiopoietin-1 receptor
(Homo sapiens (Human)) | BDBM50311975
(2-(1-isobutyl-4-phenyl-1H-imidazol-5-yl)thiazolo[5...)Show InChI InChI=1S/C18H18N6S/c1-11(2)8-24-10-22-13(12-6-4-3-5-7-12)15(24)18-23-14-16(19)20-9-21-17(14)25-18/h3-7,9-11H,8H2,1-2H3,(H2,19,20,21) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
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| CHEMBL
PC cid
PC sid
UniChem
Similars
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PubMed
| n/a | n/a | 490 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of Tie-2 phosphorylation by cell based assay |
Bioorg Med Chem Lett 19: 6670-4 (2009)
Article DOI: 10.1016/j.bmcl.2009.10.001
BindingDB Entry DOI: 10.7270/Q2FN16BJ |
More data for this
Ligand-Target Pair | |
Angiopoietin-1 receptor
(Homo sapiens (Human)) | BDBM50311974
(2-(1-(cyclohexylmethyl)-4-phenyl-1H-imidazol-5-yl)...)Show SMILES Nc1ncnc2sc(nc12)-c1c(ncn1CC1CCCCC1)-c1ccccc1 Show InChI InChI=1S/C21H22N6S/c22-19-17-20(24-12-23-19)28-21(26-17)18-16(15-9-5-2-6-10-15)25-13-27(18)11-14-7-3-1-4-8-14/h2,5-6,9-10,12-14H,1,3-4,7-8,11H2,(H2,22,23,24) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
MMDB
PC cid
PC sid
PDB
UniChem
Similars
| MMDB
PDB
Article
PubMed
| n/a | n/a | 540 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of Tie-2 phosphorylation by cell based assay |
Bioorg Med Chem Lett 19: 6670-4 (2009)
Article DOI: 10.1016/j.bmcl.2009.10.001
BindingDB Entry DOI: 10.7270/Q2FN16BJ |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Angiopoietin-1 receptor
(Homo sapiens (Human)) | BDBM50311968
(6-(1-methyl-4-(3-(p-tolylthio)phenyl)-1H-imidazol-...)Show SMILES Cc1ccc(Sc2cccc(c2)-c2ncn(C)c2-c2cc3c(N)ncnc3s2)cc1 Show InChI InChI=1S/C23H19N5S2/c1-14-6-8-16(9-7-14)29-17-5-3-4-15(10-17)20-21(28(2)13-27-20)19-11-18-22(24)25-12-26-23(18)30-19/h3-13H,1-2H3,(H2,24,25,26) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of Tie-2 phosphorylation by cell based assay |
Bioorg Med Chem Lett 19: 6670-4 (2009)
Article DOI: 10.1016/j.bmcl.2009.10.001
BindingDB Entry DOI: 10.7270/Q2FN16BJ |
More data for this
Ligand-Target Pair | |
Angiopoietin-1 receptor
(Homo sapiens (Human)) | BDBM50311969
(1-(3-(5-(4-aminothieno[2,3-d]pyrimidin-6-yl)-1-met...)Show SMILES Cn1cnc(c1-c1cc2c(N)ncnc2s1)-c1cccc(NC(=O)Nc2ccccc2)c1 Show InChI InChI=1S/C23H19N7OS/c1-30-13-27-19(20(30)18-11-17-21(24)25-12-26-22(17)32-18)14-6-5-9-16(10-14)29-23(31)28-15-7-3-2-4-8-15/h2-13H,1H3,(H2,24,25,26)(H2,28,29,31) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of Tie-2 phosphorylation by cell based assay |
Bioorg Med Chem Lett 19: 6670-4 (2009)
Article DOI: 10.1016/j.bmcl.2009.10.001
BindingDB Entry DOI: 10.7270/Q2FN16BJ |
More data for this
Ligand-Target Pair | |
Angiopoietin-1 receptor
(Homo sapiens (Human)) | BDBM50311967
(6-(1-methyl-4-phenyl-1H-imidazol-5-yl)thieno[2,3-d...)Show InChI InChI=1S/C16H13N5S/c1-21-9-20-13(10-5-3-2-4-6-10)14(21)12-7-11-15(17)18-8-19-16(11)22-12/h2-9H,1H3,(H2,17,18,19) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of Tie-2 phosphorylation by cell based assay |
Bioorg Med Chem Lett 19: 6670-4 (2009)
Article DOI: 10.1016/j.bmcl.2009.10.001
BindingDB Entry DOI: 10.7270/Q2FN16BJ |
More data for this
Ligand-Target Pair | |
Angiopoietin-1 receptor
(Homo sapiens (Human)) | BDBM50311972
(2-(1-methyl-4-phenyl-1H-imidazol-5-yl)thiazolo[5,4...)Show InChI InChI=1S/C15H12N6S/c1-21-8-19-10(9-5-3-2-4-6-9)12(21)15-20-11-13(16)17-7-18-14(11)22-15/h2-8H,1H3,(H2,16,17,18) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of Tie-2 phosphorylation by cell based assay |
Bioorg Med Chem Lett 19: 6670-4 (2009)
Article DOI: 10.1016/j.bmcl.2009.10.001
BindingDB Entry DOI: 10.7270/Q2FN16BJ |
More data for this
Ligand-Target Pair | |
Angiopoietin-1 receptor
(Homo sapiens (Human)) | BDBM50311973
(2-(1-ethyl-4-phenyl-1H-imidazol-5-yl)thiazolo[5,4-...)Show InChI InChI=1S/C16H14N6S/c1-2-22-9-20-11(10-6-4-3-5-7-10)13(22)16-21-12-14(17)18-8-19-15(12)23-16/h3-9H,2H2,1H3,(H2,17,18,19) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of Tie-2 phosphorylation by cell based assay |
Bioorg Med Chem Lett 19: 6670-4 (2009)
Article DOI: 10.1016/j.bmcl.2009.10.001
BindingDB Entry DOI: 10.7270/Q2FN16BJ |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 1
(Homo sapiens (Human)) | BDBM50311972
(2-(1-methyl-4-phenyl-1H-imidazol-5-yl)thiazolo[5,4...)Show InChI InChI=1S/C15H12N6S/c1-21-8-19-10(9-5-3-2-4-6-9)12(21)15-20-11-13(16)17-7-18-14(11)22-15/h2-8H,1H3,(H2,16,17,18) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of FLt |
Bioorg Med Chem Lett 19: 6670-4 (2009)
Article DOI: 10.1016/j.bmcl.2009.10.001
BindingDB Entry DOI: 10.7270/Q2FN16BJ |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50311967
(6-(1-methyl-4-phenyl-1H-imidazol-5-yl)thieno[2,3-d...)Show InChI InChI=1S/C16H13N5S/c1-21-9-20-13(10-5-3-2-4-6-10)14(21)12-7-11-15(17)18-8-19-16(11)22-12/h2-9H,1H3,(H2,17,18,19) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of KDR |
Bioorg Med Chem Lett 19: 6670-4 (2009)
Article DOI: 10.1016/j.bmcl.2009.10.001
BindingDB Entry DOI: 10.7270/Q2FN16BJ |
More data for this
Ligand-Target Pair | |
Angiopoietin-1 receptor
(Homo sapiens (Human)) | BDBM50311972
(2-(1-methyl-4-phenyl-1H-imidazol-5-yl)thiazolo[5,4...)Show InChI InChI=1S/C15H12N6S/c1-21-8-19-10(9-5-3-2-4-6-9)12(21)15-20-11-13(16)17-7-18-14(11)22-15/h2-8H,1H3,(H2,16,17,18) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of Tie-2 |
Bioorg Med Chem Lett 19: 6670-4 (2009)
Article DOI: 10.1016/j.bmcl.2009.10.001
BindingDB Entry DOI: 10.7270/Q2FN16BJ |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 1
(Homo sapiens (Human)) | BDBM50311967
(6-(1-methyl-4-phenyl-1H-imidazol-5-yl)thieno[2,3-d...)Show InChI InChI=1S/C16H13N5S/c1-21-9-20-13(10-5-3-2-4-6-10)14(21)12-7-11-15(17)18-8-19-16(11)22-12/h2-9H,1H3,(H2,17,18,19) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of FLt |
Bioorg Med Chem Lett 19: 6670-4 (2009)
Article DOI: 10.1016/j.bmcl.2009.10.001
BindingDB Entry DOI: 10.7270/Q2FN16BJ |
More data for this
Ligand-Target Pair | |
Angiopoietin-1 receptor
(Homo sapiens (Human)) | BDBM50311967
(6-(1-methyl-4-phenyl-1H-imidazol-5-yl)thieno[2,3-d...)Show InChI InChI=1S/C16H13N5S/c1-21-9-20-13(10-5-3-2-4-6-10)14(21)12-7-11-15(17)18-8-19-16(11)22-12/h2-9H,1H3,(H2,17,18,19) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.40E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of Tie-2 |
Bioorg Med Chem Lett 19: 6670-4 (2009)
Article DOI: 10.1016/j.bmcl.2009.10.001
BindingDB Entry DOI: 10.7270/Q2FN16BJ |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50311972
(2-(1-methyl-4-phenyl-1H-imidazol-5-yl)thiazolo[5,4...)Show InChI InChI=1S/C15H12N6S/c1-21-8-19-10(9-5-3-2-4-6-9)12(21)15-20-11-13(16)17-7-18-14(11)22-15/h2-8H,1H3,(H2,16,17,18) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 8.40E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of KDR |
Bioorg Med Chem Lett 19: 6670-4 (2009)
Article DOI: 10.1016/j.bmcl.2009.10.001
BindingDB Entry DOI: 10.7270/Q2FN16BJ |
More data for this
Ligand-Target Pair | |
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