Found 166 hits with Last Name = 'swartz' and Initial = 'sg' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50371684
(CHEMBL270666)Show SMILES CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1[C@@H](COc1ccccc1O)CC#N Show InChI InChI=1S/C24H29N7O4/c1-24(2,26)23(33)27-19(16-34-14-17-8-4-3-5-9-17)22-28-29-30-31(22)18(12-13-25)15-35-21-11-7-6-10-20(21)32/h3-11,18-19,32H,12,14-16,26H2,1-2H3,(H,27,33)/t18-,19-/m1/s1 | PDB
Reactome pathway
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| CHEMBL
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PC sid
UniChem
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| Article
PubMed
| 5.70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Agonist activity at human GHS receptor expressed in H4 glioma cells |
Bioorg Med Chem Lett 18: 2067-72 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.100
BindingDB Entry DOI: 10.7270/Q21G0N4D |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50371688
(CHEMBL404545)Show SMILES CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1[C@@H](COc1ccccc1)CC#N Show InChI InChI=1S/C24H29N7O3/c1-24(2,26)23(32)27-21(17-33-15-18-9-5-3-6-10-18)22-28-29-30-31(22)19(13-14-25)16-34-20-11-7-4-8-12-20/h3-12,19,21H,13,15-17,26H2,1-2H3,(H,27,32)/t19-,21-/m1/s1 | PDB
Reactome pathway
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PC cid
PC sid
UniChem
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| Article
PubMed
| 7.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Agonist activity at human GHS receptor expressed in H4 glioma cells |
Bioorg Med Chem Lett 18: 2067-72 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.100
BindingDB Entry DOI: 10.7270/Q21G0N4D |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50371686
(CHEMBL271876)Show SMILES CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1[C@@H](COc1ccccn1)CC#N Show InChI InChI=1S/C23H28N8O3/c1-23(2,25)22(32)27-19(16-33-14-17-8-4-3-5-9-17)21-28-29-30-31(21)18(11-12-24)15-34-20-10-6-7-13-26-20/h3-10,13,18-19H,11,14-16,25H2,1-2H3,(H,27,32)/t18-,19-/m1/s1 | PDB
Reactome pathway
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PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Agonist activity at human GHS receptor expressed in H4 glioma cells |
Bioorg Med Chem Lett 18: 2067-72 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.100
BindingDB Entry DOI: 10.7270/Q21G0N4D |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50222142
((S,E)-2-amino-N-(2-(benzyloxy)-1-(1-cinnamyl-1H-te...)Show SMILES CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C\C=C\c1ccccc1 Show InChI InChI=1S/C23H28N6O2/c1-23(2,24)22(30)25-20(17-31-16-19-12-7-4-8-13-19)21-26-27-28-29(21)15-9-14-18-10-5-3-6-11-18/h3-14,20H,15-17,24H2,1-2H3,(H,25,30)/b14-9+/t20-/m1/s1 | PDB
Reactome pathway
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| Article
PubMed
| 190 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]Ghrelin from human GHSR1a after 1 hr |
Bioorg Med Chem Lett 17: 5928-33 (2007)
Article DOI: 10.1016/j.bmcl.2007.07.099
BindingDB Entry DOI: 10.7270/Q28P607D |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50371687
(CHEMBL272085)Show SMILES CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1[C@H](COc1ccccc1)CC#N Show InChI InChI=1S/C24H29N7O3/c1-24(2,26)23(32)27-21(17-33-15-18-9-5-3-6-10-18)22-28-29-30-31(22)19(13-14-25)16-34-20-11-7-4-8-12-20/h3-12,19,21H,13,15-17,26H2,1-2H3,(H,27,32)/t19-,21+/m0/s1 | PDB
Reactome pathway
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PC sid
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| Article
PubMed
| 197 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Agonist activity at human GHS receptor expressed in H4 glioma cells |
Bioorg Med Chem Lett 18: 2067-72 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.100
BindingDB Entry DOI: 10.7270/Q21G0N4D |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50222164
((S)-2-amino-N-(2-(benzyloxy)-1-(1-(3-phenylpropyl)...)Show SMILES CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCc1ccccc1 Show InChI InChI=1S/C23H30N6O2/c1-23(2,24)22(30)25-20(17-31-16-19-12-7-4-8-13-19)21-26-27-28-29(21)15-9-14-18-10-5-3-6-11-18/h3-8,10-13,20H,9,14-17,24H2,1-2H3,(H,25,30)/t20-/m1/s1 | PDB
Reactome pathway
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PC sid
UniChem
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| Article
PubMed
| 200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Agonist activity at human GHS receptor expressed in H4 glioma cells |
Bioorg Med Chem Lett 18: 2067-72 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.100
BindingDB Entry DOI: 10.7270/Q21G0N4D |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50222164
((S)-2-amino-N-(2-(benzyloxy)-1-(1-(3-phenylpropyl)...)Show SMILES CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCc1ccccc1 Show InChI InChI=1S/C23H30N6O2/c1-23(2,24)22(30)25-20(17-31-16-19-12-7-4-8-13-19)21-26-27-28-29(21)15-9-14-18-10-5-3-6-11-18/h3-8,10-13,20H,9,14-17,24H2,1-2H3,(H,25,30)/t20-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
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| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]Ghrelin from human GHSR1a after 1 hr |
Bioorg Med Chem Lett 17: 5928-33 (2007)
Article DOI: 10.1016/j.bmcl.2007.07.099
BindingDB Entry DOI: 10.7270/Q28P607D |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50371683
(CHEMBL410060)Show SMILES CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1[C@H](COc1ccccc1O)CC#N Show InChI InChI=1S/C24H29N7O4/c1-24(2,26)23(33)27-19(16-34-14-17-8-4-3-5-9-17)22-28-29-30-31(22)18(12-13-25)15-35-21-11-7-6-10-20(21)32/h3-11,18-19,32H,12,14-16,26H2,1-2H3,(H,27,33)/t18-,19+/m0/s1 | PDB
Reactome pathway
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UniProtKB/SwissProt
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 240 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Agonist activity at human GHS receptor expressed in H4 glioma cells |
Bioorg Med Chem Lett 18: 2067-72 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.100
BindingDB Entry DOI: 10.7270/Q21G0N4D |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50371693
(CHEMBL402086)Show SMILES CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CC(Cc1ccccc1)C#N |w:23.24| Show InChI InChI=1S/C24H29N7O2/c1-24(2,26)23(32)27-21(17-33-16-19-11-7-4-8-12-19)22-28-29-30-31(22)15-20(14-25)13-18-9-5-3-6-10-18/h3-12,20-21H,13,15-17,26H2,1-2H3,(H,27,32)/t20?,21-/m1/s1 | PDB
Reactome pathway
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UniChem
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| Article
PubMed
| 298 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Agonist activity at human GHS receptor expressed in H4 glioma cells |
Bioorg Med Chem Lett 18: 2067-72 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.100
BindingDB Entry DOI: 10.7270/Q21G0N4D |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50222147
((S)-benzyl 5-(5-(1-(2-amino-2-methylpropanamido)-2...)Show SMILES CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCCCNC(=O)OCc1ccccc1 Show InChI InChI=1S/C27H37N7O4/c1-27(2,28)25(35)30-23(20-37-18-21-12-6-3-7-13-21)24-31-32-33-34(24)17-11-5-10-16-29-26(36)38-19-22-14-8-4-9-15-22/h3-4,6-9,12-15,23H,5,10-11,16-20,28H2,1-2H3,(H,29,36)(H,30,35)/t23-/m1/s1 | PDB
Reactome pathway
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PubMed
| 320 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]Ghrelin from human GHSR1a after 1 hr |
Bioorg Med Chem Lett 17: 5928-33 (2007)
Article DOI: 10.1016/j.bmcl.2007.07.099
BindingDB Entry DOI: 10.7270/Q28P607D |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50222136
(CHEMBL235793 | methyl 2-(5-((S)-1-(2-amino-2-methy...)Show SMILES COC(=O)C(c1ccccc1)n1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N |w:4.3| Show InChI InChI=1S/C23H28N6O4/c1-23(2,24)22(31)25-18(15-33-14-16-10-6-4-7-11-16)20-26-27-28-29(20)19(21(30)32-3)17-12-8-5-9-13-17/h4-13,18-19H,14-15,24H2,1-3H3,(H,25,31)/t18-,19?/m1/s1 | PDB
Reactome pathway
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PC cid
PC sid
UniChem
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| Article
PubMed
| 470 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]Ghrelin from human GHSR1a after 1 hr |
Bioorg Med Chem Lett 17: 5928-33 (2007)
Article DOI: 10.1016/j.bmcl.2007.07.099
BindingDB Entry DOI: 10.7270/Q28P607D |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50371685
(CHEMBL270876)Show SMILES CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1[C@H](COc1ccccn1)CC#N Show InChI InChI=1S/C23H28N8O3/c1-23(2,25)22(32)27-19(16-33-14-17-8-4-3-5-9-17)21-28-29-30-31(21)18(11-12-24)15-34-20-10-6-7-13-26-20/h3-10,13,18-19H,11,14-16,25H2,1-2H3,(H,27,32)/t18-,19+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 503 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Agonist activity at human GHS receptor expressed in H4 glioma cells |
Bioorg Med Chem Lett 18: 2067-72 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.100
BindingDB Entry DOI: 10.7270/Q21G0N4D |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50371691
(CHEMBL270851)Show SMILES CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC(C#N)c1ccccc1 |w:24.25| Show InChI InChI=1S/C24H29N7O2/c1-24(2,26)23(32)27-21(17-33-16-18-9-5-3-6-10-18)22-28-29-30-31(22)14-13-20(15-25)19-11-7-4-8-12-19/h3-12,20-21H,13-14,16-17,26H2,1-2H3,(H,27,32)/t20?,21-/m1/s1 | PDB
Reactome pathway
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PC sid
UniChem
Similars
| Article
PubMed
| 611 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Agonist activity at human GHS receptor expressed in H4 glioma cells |
Bioorg Med Chem Lett 18: 2067-72 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.100
BindingDB Entry DOI: 10.7270/Q21G0N4D |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50371689
(CHEMBL256235)Show SMILES CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C(COc1ccccc1F)CC#N |w:22.34| Show InChI InChI=1S/C24H28FN7O3/c1-24(2,27)23(33)28-20(16-34-14-17-8-4-3-5-9-17)22-29-30-31-32(22)18(12-13-26)15-35-21-11-7-6-10-19(21)25/h3-11,18,20H,12,14-16,27H2,1-2H3,(H,28,33)/t18?,20-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
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| CHEMBL
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PC sid
UniChem
Similars
| Article
PubMed
| 696 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Agonist activity at human GHS receptor expressed in H4 glioma cells |
Bioorg Med Chem Lett 18: 2067-72 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.100
BindingDB Entry DOI: 10.7270/Q21G0N4D |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50371689
(CHEMBL256235)Show SMILES CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C(COc1ccccc1F)CC#N |w:22.34| Show InChI InChI=1S/C24H28FN7O3/c1-24(2,27)23(33)28-20(16-34-14-17-8-4-3-5-9-17)22-29-30-31-32(22)18(12-13-26)15-35-21-11-7-6-10-19(21)25/h3-11,18,20H,12,14-16,27H2,1-2H3,(H,28,33)/t18?,20-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 696 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Agonist activity at human GHS receptor expressed in H4 glioma cells |
Bioorg Med Chem Lett 18: 2067-72 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.100
BindingDB Entry DOI: 10.7270/Q21G0N4D |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50371697
(CHEMBL404336)Show SMILES CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C(CC#N)\C=C\c1ccccc1 |w:22.24| Show InChI InChI=1S/C25H29N7O2/c1-25(2,27)24(33)28-22(18-34-17-20-11-7-4-8-12-20)23-29-30-31-32(23)21(15-16-26)14-13-19-9-5-3-6-10-19/h3-14,21-22H,15,17-18,27H2,1-2H3,(H,28,33)/b14-13+/t21?,22-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
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AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 737 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Agonist activity at human GHS receptor expressed in H4 glioma cells |
Bioorg Med Chem Lett 18: 2067-72 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.100
BindingDB Entry DOI: 10.7270/Q21G0N4D |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50371697
(CHEMBL404336)Show SMILES CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C(CC#N)\C=C\c1ccccc1 |w:22.24| Show InChI InChI=1S/C25H29N7O2/c1-25(2,27)24(33)28-22(18-34-17-20-11-7-4-8-12-20)23-29-30-31-32(23)21(15-16-26)14-13-19-9-5-3-6-10-19/h3-14,21-22H,15,17-18,27H2,1-2H3,(H,28,33)/b14-13+/t21?,22-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 737 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Agonist activity at human GHS receptor expressed in H4 glioma cells |
Bioorg Med Chem Lett 18: 2067-72 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.100
BindingDB Entry DOI: 10.7270/Q21G0N4D |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50222157
(2-amino-N-{(S)-2-benzyloxy-1-[1-(2-phenethylcarbam...)Show SMILES CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC(=O)NCCc1ccccc1 Show InChI InChI=1S/C25H33N7O3/c1-25(2,26)24(34)28-21(18-35-17-20-11-7-4-8-12-20)23-29-30-31-32(23)16-14-22(33)27-15-13-19-9-5-3-6-10-19/h3-12,21H,13-18,26H2,1-2H3,(H,27,33)(H,28,34)/t21-/m1/s1 | PDB
Reactome pathway
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| 780 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]Ghrelin from human GHSR1a after 1 hr |
Bioorg Med Chem Lett 17: 5928-33 (2007)
Article DOI: 10.1016/j.bmcl.2007.07.099
BindingDB Entry DOI: 10.7270/Q28P607D |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50222166
(2-amino-N-((S)-2-benzyloxy-1-{1-[2-(3-phenyl-propy...)Show SMILES CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC(=O)NCCCc1ccccc1 Show InChI InChI=1S/C26H35N7O3/c1-26(2,27)25(35)29-22(19-36-18-21-12-7-4-8-13-21)24-30-31-32-33(24)17-15-23(34)28-16-9-14-20-10-5-3-6-11-20/h3-8,10-13,22H,9,14-19,27H2,1-2H3,(H,28,34)(H,29,35)/t22-/m1/s1 | PDB
Reactome pathway
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| 820 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]Ghrelin from human GHSR1a after 1 hr |
Bioorg Med Chem Lett 17: 5928-33 (2007)
Article DOI: 10.1016/j.bmcl.2007.07.099
BindingDB Entry DOI: 10.7270/Q28P607D |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50222162
((S)-2-amino-N-(2-(benzyloxy)-1-(1-(2-(1-(methylsul...)Show SMILES CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCc1cc2ccccc2n1S(C)(=O)=O Show InChI InChI=1S/C25H31N7O4S/c1-25(2,26)24(33)27-21(17-36-16-18-9-5-4-6-10-18)23-28-29-30-31(23)14-13-20-15-19-11-7-8-12-22(19)32(20)37(3,34)35/h4-12,15,21H,13-14,16-17,26H2,1-3H3,(H,27,33)/t21-/m1/s1 | PDB
Reactome pathway
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| 970 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]Ghrelin from human GHSR1a after 1 hr |
Bioorg Med Chem Lett 17: 5928-33 (2007)
Article DOI: 10.1016/j.bmcl.2007.07.099
BindingDB Entry DOI: 10.7270/Q28P607D |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50222167
(2-amino-N-{(S)-1-[1-(2-benzylcarbamoyl-ethyl)-1H-t...)Show SMILES CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC(=O)NCc1ccccc1 Show InChI InChI=1S/C24H31N7O3/c1-24(2,25)23(33)27-20(17-34-16-19-11-7-4-8-12-19)22-28-29-30-31(22)14-13-21(32)26-15-18-9-5-3-6-10-18/h3-12,20H,13-17,25H2,1-2H3,(H,26,32)(H,27,33)/t20-/m1/s1 | PDB
Reactome pathway
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| 1.07E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]Ghrelin from human GHSR1a after 1 hr |
Bioorg Med Chem Lett 17: 5928-33 (2007)
Article DOI: 10.1016/j.bmcl.2007.07.099
BindingDB Entry DOI: 10.7270/Q28P607D |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50222173
((S)-2-amino-N-(2-(benzyloxy)-1-(2-(2-(1-(methylsul...)Show SMILES CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(CCc2cc3ccccc3n2S(C)(=O)=O)n1 Show InChI InChI=1S/C25H31N7O4S/c1-25(2,26)24(33)27-21(17-36-16-18-9-5-4-6-10-18)23-28-30-31(29-23)14-13-20-15-19-11-7-8-12-22(19)32(20)37(3,34)35/h4-12,15,21H,13-14,16-17,26H2,1-3H3,(H,27,33)/t21-/m1/s1 | PDB
Reactome pathway
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| 1.27E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]Ghrelin from human GHSR1a after 1 hr |
Bioorg Med Chem Lett 17: 5928-33 (2007)
Article DOI: 10.1016/j.bmcl.2007.07.099
BindingDB Entry DOI: 10.7270/Q28P607D |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50222150
(2-amino-N-{(R)-1-[1-(2-butylcarbamoyl-ethyl)-1H-te...)Show SMILES CCCCNC(=O)CCn1nnnc1[C@@H](CCc1ccccc1)NC(=O)C(C)(C)N Show InChI InChI=1S/C21H33N7O2/c1-4-5-14-23-18(29)13-15-28-19(25-26-27-28)17(24-20(30)21(2,3)22)12-11-16-9-7-6-8-10-16/h6-10,17H,4-5,11-15,22H2,1-3H3,(H,23,29)(H,24,30)/t17-/m1/s1 | PDB
Reactome pathway
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| 1.37E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]Ghrelin from human GHSR1a after 1 hr |
Bioorg Med Chem Lett 17: 5928-33 (2007)
Article DOI: 10.1016/j.bmcl.2007.07.099
BindingDB Entry DOI: 10.7270/Q28P607D |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50371695
(CHEMBL403180)Show SMILES CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C(CCc1ccccc1)CC#N |w:22.33| Show InChI InChI=1S/C25H31N7O2/c1-25(2,27)24(33)28-22(18-34-17-20-11-7-4-8-12-20)23-29-30-31-32(23)21(15-16-26)14-13-19-9-5-3-6-10-19/h3-12,21-22H,13-15,17-18,27H2,1-2H3,(H,28,33)/t21?,22-/m1/s1 | PDB
Reactome pathway
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| 1.38E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Agonist activity at human GHS receptor expressed in H4 glioma cells |
Bioorg Med Chem Lett 18: 2067-72 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.100
BindingDB Entry DOI: 10.7270/Q21G0N4D |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50371695
(CHEMBL403180)Show SMILES CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C(CCc1ccccc1)CC#N |w:22.33| Show InChI InChI=1S/C25H31N7O2/c1-25(2,27)24(33)28-22(18-34-17-20-11-7-4-8-12-20)23-29-30-31-32(23)21(15-16-26)14-13-19-9-5-3-6-10-19/h3-12,21-22H,13-15,17-18,27H2,1-2H3,(H,28,33)/t21?,22-/m1/s1 | PDB
Reactome pathway
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| 1.38E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Agonist activity at human GHS receptor expressed in H4 glioma cells |
Bioorg Med Chem Lett 18: 2067-72 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.100
BindingDB Entry DOI: 10.7270/Q21G0N4D |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50222151
(2-amino-N-((S)-2-(benzyloxy)-1-(1-((1-(methylsulfo...)Show SMILES CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CC1CN(c2ccccc12)S(C)(=O)=O |w:23.24| Show InChI InChI=1S/C24H31N7O4S/c1-24(2,25)23(32)26-20(16-35-15-17-9-5-4-6-10-17)22-27-28-29-30(22)13-18-14-31(36(3,33)34)21-12-8-7-11-19(18)21/h4-12,18,20H,13-16,25H2,1-3H3,(H,26,32)/t18?,20-/m1/s1 | PDB
Reactome pathway
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| 1.59E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]Ghrelin from human GHSR1a after 1 hr |
Bioorg Med Chem Lett 17: 5928-33 (2007)
Article DOI: 10.1016/j.bmcl.2007.07.099
BindingDB Entry DOI: 10.7270/Q28P607D |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50222161
((S)-2-amino-N-(2-(benzyloxy)-1-(1-(3-(2-(N-methylm...)Show SMILES CN(c1ccccc1CCCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N)S(C)(=O)=O Show InChI InChI=1S/C25H35N7O4S/c1-25(2,26)24(33)27-21(18-36-17-19-11-6-5-7-12-19)23-28-29-30-32(23)16-10-14-20-13-8-9-15-22(20)31(3)37(4,34)35/h5-9,11-13,15,21H,10,14,16-18,26H2,1-4H3,(H,27,33)/t21-/m1/s1 | PDB
Reactome pathway
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| 1.72E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]Ghrelin from human GHSR1a after 1 hr |
Bioorg Med Chem Lett 17: 5928-33 (2007)
Article DOI: 10.1016/j.bmcl.2007.07.099
BindingDB Entry DOI: 10.7270/Q28P607D |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50222146
((S)-4-(5-(1-(2-amino-2-methylpropanamido)-2-(benzy...)Show SMILES CCCCNC(=O)CCCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N Show InChI InChI=1S/C22H35N7O3/c1-4-5-13-24-19(30)12-9-14-29-20(26-27-28-29)18(25-21(31)22(2,3)23)16-32-15-17-10-7-6-8-11-17/h6-8,10-11,18H,4-5,9,12-16,23H2,1-3H3,(H,24,30)(H,25,31)/t18-/m1/s1 | PDB
Reactome pathway
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| 1.78E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]Ghrelin from human GHSR1a after 1 hr |
Bioorg Med Chem Lett 17: 5928-33 (2007)
Article DOI: 10.1016/j.bmcl.2007.07.099
BindingDB Entry DOI: 10.7270/Q28P607D |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50222153
((S)-2-amino-N-(1-(1-benzyl-1H-tetrazol-5-yl)-2-(be...)Show SMILES CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1Cc1ccccc1 Show InChI InChI=1S/C21H26N6O2/c1-21(2,22)20(28)23-18(15-29-14-17-11-7-4-8-12-17)19-24-25-26-27(19)13-16-9-5-3-6-10-16/h3-12,18H,13-15,22H2,1-2H3,(H,23,28)/t18-/m1/s1 | PDB
Reactome pathway
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| 1.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]Ghrelin from human GHSR1a after 1 hr |
Bioorg Med Chem Lett 17: 5928-33 (2007)
Article DOI: 10.1016/j.bmcl.2007.07.099
BindingDB Entry DOI: 10.7270/Q28P607D |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50222165
(2-amino-N-{(S)-2-benzyloxy-1-[1-(2-butylcarbamoyl-...)Show SMILES CCCCNC(=O)CCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N Show InChI InChI=1S/C21H33N7O3/c1-4-5-12-23-18(29)11-13-28-19(25-26-27-28)17(24-20(30)21(2,3)22)15-31-14-16-9-7-6-8-10-16/h6-10,17H,4-5,11-15,22H2,1-3H3,(H,23,29)(H,24,30)/t17-/m1/s1 | PDB
Reactome pathway
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| 2.19E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]Ghrelin from human GHSR1a after 1 hr |
Bioorg Med Chem Lett 17: 5928-33 (2007)
Article DOI: 10.1016/j.bmcl.2007.07.099
BindingDB Entry DOI: 10.7270/Q28P607D |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50222143
((S)-N-(1-(1-(2-(methylsulfonamido)phenethyl)-1H-te...)Show SMILES CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCc1ccccc1NS(C)(=O)=O Show InChI InChI=1S/C23H31N7O4S/c1-23(2,24)22(31)25-20(16-34-15-17-9-5-4-6-10-17)21-26-28-29-30(21)14-13-18-11-7-8-12-19(18)27-35(3,32)33/h4-12,20,27H,13-16,24H2,1-3H3,(H,25,31)/t20-/m1/s1 | PDB
Reactome pathway
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| 2.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]Ghrelin from human GHSR1a after 1 hr |
Bioorg Med Chem Lett 17: 5928-33 (2007)
Article DOI: 10.1016/j.bmcl.2007.07.099
BindingDB Entry DOI: 10.7270/Q28P607D |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50222172
((S)-methyl 4-(5-(1-(2-amino-2-methylpropanamido)-2...)Show SMILES COC(=O)CCCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N Show InChI InChI=1S/C19H28N6O4/c1-19(2,20)18(27)21-15(13-29-12-14-8-5-4-6-9-14)17-22-23-24-25(17)11-7-10-16(26)28-3/h4-6,8-9,15H,7,10-13,20H2,1-3H3,(H,21,27)/t15-/m1/s1 | PDB
Reactome pathway
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| 2.38E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]Ghrelin from human GHSR1a after 1 hr |
Bioorg Med Chem Lett 17: 5928-33 (2007)
Article DOI: 10.1016/j.bmcl.2007.07.099
BindingDB Entry DOI: 10.7270/Q28P607D |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50222158
((S)-2-amino-N-(2-(benzyloxy)-1-(2-(3-(2-(methylsul...)Show SMILES CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(CCCc2ccccc2NS(C)(=O)=O)n1 Show InChI InChI=1S/C24H33N7O4S/c1-24(2,25)23(32)26-21(17-35-16-18-10-5-4-6-11-18)22-27-30-31(28-22)15-9-13-19-12-7-8-14-20(19)29-36(3,33)34/h4-8,10-12,14,21,29H,9,13,15-17,25H2,1-3H3,(H,26,32)/t21-/m1/s1 | PDB
Reactome pathway
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| 2.39E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]Ghrelin from human GHSR1a after 1 hr |
Bioorg Med Chem Lett 17: 5928-33 (2007)
Article DOI: 10.1016/j.bmcl.2007.07.099
BindingDB Entry DOI: 10.7270/Q28P607D |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50371696
(CHEMBL271082)Show SMILES CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(n1)C(CC#N)\C=C\c1ccccc1 |w:22.24| Show InChI InChI=1S/C25H29N7O2/c1-25(2,27)24(33)28-22(18-34-17-20-11-7-4-8-12-20)23-29-31-32(30-23)21(15-16-26)14-13-19-9-5-3-6-10-19/h3-14,21-22H,15,17-18,27H2,1-2H3,(H,28,33)/b14-13+/t21?,22-/m1/s1 | PDB
Reactome pathway
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| 2.51E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Agonist activity at human GHS receptor expressed in H4 glioma cells |
Bioorg Med Chem Lett 18: 2067-72 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.100
BindingDB Entry DOI: 10.7270/Q21G0N4D |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50371696
(CHEMBL271082)Show SMILES CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(n1)C(CC#N)\C=C\c1ccccc1 |w:22.24| Show InChI InChI=1S/C25H29N7O2/c1-25(2,27)24(33)28-22(18-34-17-20-11-7-4-8-12-20)23-29-31-32(30-23)21(15-16-26)14-13-19-9-5-3-6-10-19/h3-14,21-22H,15,17-18,27H2,1-2H3,(H,28,33)/b14-13+/t21?,22-/m1/s1 | PDB
Reactome pathway
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| 2.51E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Agonist activity at human GHS receptor expressed in H4 glioma cells |
Bioorg Med Chem Lett 18: 2067-72 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.100
BindingDB Entry DOI: 10.7270/Q21G0N4D |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50222139
((S)-N-(1-(2-(2-(methylsulfonamido)phenethyl)-2H-te...)Show SMILES CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(CCc2ccccc2NS(C)(=O)=O)n1 Show InChI InChI=1S/C23H31N7O4S/c1-23(2,24)22(31)25-20(16-34-15-17-9-5-4-6-10-17)21-26-29-30(27-21)14-13-18-11-7-8-12-19(18)28-35(3,32)33/h4-12,20,28H,13-16,24H2,1-3H3,(H,25,31)/t20-/m1/s1 | PDB
Reactome pathway
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PubMed
| 2.66E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]Ghrelin from human GHSR1a after 1 hr |
Bioorg Med Chem Lett 17: 5928-33 (2007)
Article DOI: 10.1016/j.bmcl.2007.07.099
BindingDB Entry DOI: 10.7270/Q28P607D |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50222148
((S)-2-amino-N-(2-(benzyloxy)-1-(1-(2-cyanoethyl)-1...)Show SMILES CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC#N |r| Show InChI InChI=1S/C17H23N7O2/c1-17(2,19)16(25)20-14(12-26-11-13-7-4-3-5-8-13)15-21-22-23-24(15)10-6-9-18/h3-5,7-8,14H,6,10-12,19H2,1-2H3,(H,20,25)/t14-/m1/s1 | PDB
Reactome pathway
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PubMed
| 2.94E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]Ghrelin from human GHSR1a after 1 hr |
Bioorg Med Chem Lett 17: 5928-33 (2007)
Article DOI: 10.1016/j.bmcl.2007.07.099
BindingDB Entry DOI: 10.7270/Q28P607D |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50222148
((S)-2-amino-N-(2-(benzyloxy)-1-(1-(2-cyanoethyl)-1...)Show SMILES CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC#N |r| Show InChI InChI=1S/C17H23N7O2/c1-17(2,19)16(25)20-14(12-26-11-13-7-4-3-5-8-13)15-21-22-23-24(15)10-6-9-18/h3-5,7-8,14H,6,10-12,19H2,1-2H3,(H,20,25)/t14-/m1/s1 | PDB
Reactome pathway
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| 2.94E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Agonist activity at human GHS receptor expressed in H4 glioma cells |
Bioorg Med Chem Lett 18: 2067-72 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.100
BindingDB Entry DOI: 10.7270/Q21G0N4D |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50222156
((S)-2-amino-N-(2-(benzyloxy)-1-(1-(4-cyanobutyl)-1...)Show SMILES CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCCC#N Show InChI InChI=1S/C19H27N7O2/c1-19(2,21)18(27)22-16(14-28-13-15-9-5-3-6-10-15)17-23-24-25-26(17)12-8-4-7-11-20/h3,5-6,9-10,16H,4,7-8,12-14,21H2,1-2H3,(H,22,27)/t16-/m1/s1 | PDB
Reactome pathway
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| 3.12E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]Ghrelin from human GHSR1a after 1 hr |
Bioorg Med Chem Lett 17: 5928-33 (2007)
Article DOI: 10.1016/j.bmcl.2007.07.099
BindingDB Entry DOI: 10.7270/Q28P607D |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50222171
((S)-methyl 3-(5-(1-(2-amino-2-methylpropanamido)-2...)Show SMILES COC(=O)CCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N Show InChI InChI=1S/C18H26N6O4/c1-18(2,19)17(26)20-14(12-28-11-13-7-5-4-6-8-13)16-21-22-23-24(16)10-9-15(25)27-3/h4-8,14H,9-12,19H2,1-3H3,(H,20,26)/t14-/m1/s1 | PDB
Reactome pathway
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| 3.38E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]Ghrelin from human GHSR1a after 1 hr |
Bioorg Med Chem Lett 17: 5928-33 (2007)
Article DOI: 10.1016/j.bmcl.2007.07.099
BindingDB Entry DOI: 10.7270/Q28P607D |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50371694
(CHEMBL402808)Show SMILES CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(n1)C(CCc1ccccc1)CC#N |w:22.33| Show InChI InChI=1S/C25H31N7O2/c1-25(2,27)24(33)28-22(18-34-17-20-11-7-4-8-12-20)23-29-31-32(30-23)21(15-16-26)14-13-19-9-5-3-6-10-19/h3-12,21-22H,13-15,17-18,27H2,1-2H3,(H,28,33)/t21?,22-/m1/s1 | PDB
Reactome pathway
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PubMed
| 3.94E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Agonist activity at human GHS receptor expressed in H4 glioma cells |
Bioorg Med Chem Lett 18: 2067-72 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.100
BindingDB Entry DOI: 10.7270/Q21G0N4D |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50371694
(CHEMBL402808)Show SMILES CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(n1)C(CCc1ccccc1)CC#N |w:22.33| Show InChI InChI=1S/C25H31N7O2/c1-25(2,27)24(33)28-22(18-34-17-20-11-7-4-8-12-20)23-29-31-32(30-23)21(15-16-26)14-13-19-9-5-3-6-10-19/h3-12,21-22H,13-15,17-18,27H2,1-2H3,(H,28,33)/t21?,22-/m1/s1 | PDB
Reactome pathway
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| 3.94E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Agonist activity at human GHS receptor expressed in H4 glioma cells |
Bioorg Med Chem Lett 18: 2067-72 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.100
BindingDB Entry DOI: 10.7270/Q21G0N4D |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50222149
((S)-2-amino-N-(2-(benzyloxy)-1-(1-(cyanomethyl)-1H...)Show SMILES CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CC#N Show InChI InChI=1S/C16H21N7O2/c1-16(2,18)15(24)19-13(14-20-21-22-23(14)9-8-17)11-25-10-12-6-4-3-5-7-12/h3-7,13H,9-11,18H2,1-2H3,(H,19,24)/t13-/m1/s1 | PDB
Reactome pathway
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| 4.17E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]Ghrelin from human GHSR1a after 1 hr |
Bioorg Med Chem Lett 17: 5928-33 (2007)
Article DOI: 10.1016/j.bmcl.2007.07.099
BindingDB Entry DOI: 10.7270/Q28P607D |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50222141
((S)-N-(1-(1-(2-(methylsulfonamido)benzyl)-1H-tetra...)Show SMILES CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1Cc1ccccc1NS(C)(=O)=O Show InChI InChI=1S/C22H29N7O4S/c1-22(2,23)21(30)24-19(15-33-14-16-9-5-4-6-10-16)20-25-27-28-29(20)13-17-11-7-8-12-18(17)26-34(3,31)32/h4-12,19,26H,13-15,23H2,1-3H3,(H,24,30)/t19-/m1/s1 | PDB
Reactome pathway
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| 4.45E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]Ghrelin from human GHSR1a after 1 hr |
Bioorg Med Chem Lett 17: 5928-33 (2007)
Article DOI: 10.1016/j.bmcl.2007.07.099
BindingDB Entry DOI: 10.7270/Q28P607D |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50222168
((S)-2-amino-N-(1-(2-benzyl-2H-tetrazol-5-yl)-2-(be...)Show SMILES CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(Cc2ccccc2)n1 Show InChI InChI=1S/C21H26N6O2/c1-21(2,22)20(28)23-18(15-29-14-17-11-7-4-8-12-17)19-24-26-27(25-19)13-16-9-5-3-6-10-16/h3-12,18H,13-15,22H2,1-2H3,(H,23,28)/t18-/m1/s1 | PDB
Reactome pathway
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| 4.75E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]Ghrelin from human GHSR1a after 1 hr |
Bioorg Med Chem Lett 17: 5928-33 (2007)
Article DOI: 10.1016/j.bmcl.2007.07.099
BindingDB Entry DOI: 10.7270/Q28P607D |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50222138
((R)-methyl 3-(5-(1-(2-amino-2-methylpropanamido)-2...)Show SMILES COC(=O)CCn1nnnc1[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N Show InChI InChI=1S/C19H25N7O3/c1-19(2,20)18(28)22-15(10-12-11-21-14-7-5-4-6-13(12)14)17-23-24-25-26(17)9-8-16(27)29-3/h4-7,11,15,21H,8-10,20H2,1-3H3,(H,22,28)/t15-/m1/s1 | PDB
Reactome pathway
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| >5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]Ghrelin from human GHSR1a after 1 hr |
Bioorg Med Chem Lett 17: 5928-33 (2007)
Article DOI: 10.1016/j.bmcl.2007.07.099
BindingDB Entry DOI: 10.7270/Q28P607D |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50222144
((S)-N-(1-(2-(3-(methylsulfonamido)benzyl)-2H-tetra...)Show SMILES CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(Cc2cccc(NS(C)(=O)=O)c2)n1 Show InChI InChI=1S/C22H29N7O4S/c1-22(2,23)21(30)24-19(15-33-14-16-8-5-4-6-9-16)20-25-28-29(26-20)13-17-10-7-11-18(12-17)27-34(3,31)32/h4-12,19,27H,13-15,23H2,1-3H3,(H,24,30)/t19-/m1/s1 | PDB
Reactome pathway
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| >5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]Ghrelin from human GHSR1a after 1 hr |
Bioorg Med Chem Lett 17: 5928-33 (2007)
Article DOI: 10.1016/j.bmcl.2007.07.099
BindingDB Entry DOI: 10.7270/Q28P607D |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50222152
(2-amino-N-((S)-2-(benzyloxy)-1-(2-((1-(methylsulfo...)Show SMILES CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(CC2Cc3ccccc3N2S(C)(=O)=O)n1 |w:22.22| Show InChI InChI=1S/C24H31N7O4S/c1-24(2,25)23(32)26-20(16-35-15-17-9-5-4-6-10-17)22-27-29-30(28-22)14-19-13-18-11-7-8-12-21(18)31(19)36(3,33)34/h4-12,19-20H,13-16,25H2,1-3H3,(H,26,32)/t19?,20-/m1/s1 | PDB
Reactome pathway
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UniChem
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PubMed
| >5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]Ghrelin from human GHSR1a after 1 hr |
Bioorg Med Chem Lett 17: 5928-33 (2007)
Article DOI: 10.1016/j.bmcl.2007.07.099
BindingDB Entry DOI: 10.7270/Q28P607D |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50222154
((S)-N-(1-(1-(4-(methylsulfonamido)benzyl)-1H-tetra...)Show SMILES CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1Cc1ccc(NS(C)(=O)=O)cc1 Show InChI InChI=1S/C22H29N7O4S/c1-22(2,23)21(30)24-19(15-33-14-17-7-5-4-6-8-17)20-25-27-28-29(20)13-16-9-11-18(12-10-16)26-34(3,31)32/h4-12,19,26H,13-15,23H2,1-3H3,(H,24,30)/t19-/m1/s1 | PDB
Reactome pathway
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| >5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]Ghrelin from human GHSR1a after 1 hr |
Bioorg Med Chem Lett 17: 5928-33 (2007)
Article DOI: 10.1016/j.bmcl.2007.07.099
BindingDB Entry DOI: 10.7270/Q28P607D |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50371692
(CHEMBL404227)Show SMILES CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(CC(Cc2ccccc2)C#N)n1 |w:22.22| Show InChI InChI=1S/C24H29N7O2/c1-24(2,26)23(32)27-21(17-33-16-19-11-7-4-8-12-19)22-28-30-31(29-22)15-20(14-25)13-18-9-5-3-6-10-18/h3-12,20-21H,13,15-17,26H2,1-2H3,(H,27,32)/t20?,21-/m1/s1 | PDB
Reactome pathway
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UniChem
Similars
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PubMed
| >5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Agonist activity at human GHS receptor expressed in H4 glioma cells |
Bioorg Med Chem Lett 18: 2067-72 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.100
BindingDB Entry DOI: 10.7270/Q21G0N4D |
More data for this
Ligand-Target Pair | |
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