Found 391 hits with Last Name = 'sweeney' and Initial = 'fj' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM16384
(4-(4-fluorophenyl)-5-[3-(2-methoxyphenyl)-[1,2,4]t...)Show SMILES COc1ccccc1-c1nnc2ccc(cn12)-c1ocnc1-c1ccc(F)cc1 Show InChI InChI=1S/C22H15FN4O2/c1-28-18-5-3-2-4-17(18)22-26-25-19-11-8-15(12-27(19)22)21-20(24-13-29-21)14-6-9-16(23)10-7-14/h2-13H,1H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer
| Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al... |
Bioorg Med Chem Lett 16: 4339-44 (2006)
Article DOI: 10.1016/j.bmcl.2006.05.056
BindingDB Entry DOI: 10.7270/Q2251GFZ |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM16385
(5-[3-(2-ethoxyphenyl)-[1,2,4]triazolo[3,4-a]pyridi...)Show SMILES CCOc1ccccc1-c1nnc2ccc(cn12)-c1ocnc1-c1ccc(F)cc1 Show InChI InChI=1S/C23H17FN4O2/c1-2-29-19-6-4-3-5-18(19)23-27-26-20-12-9-16(13-28(20)23)22-21(25-14-30-22)15-7-10-17(24)11-8-15/h3-14H,2H2,1H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer
| Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al... |
Bioorg Med Chem Lett 16: 4339-44 (2006)
Article DOI: 10.1016/j.bmcl.2006.05.056
BindingDB Entry DOI: 10.7270/Q2251GFZ |
More data for this
Ligand-Target Pair | |
Disintegrin and metalloproteinase domain-containing protein 17
(Homo sapiens (Human)) | BDBM50168742
((2R,3R)-3-Hydroxy-3-methyl-1-[4-(quinolin-8-ylmeth...)Show SMILES C[C@@]1(O)CCCN([C@H]1C(=O)NO)S(=O)(=O)c1ccc(OCc2cccc3cccnc23)cc1 Show InChI InChI=1S/C23H25N3O6S/c1-23(28)12-4-14-26(21(23)22(27)25-29)33(30,31)19-10-8-18(9-11-19)32-15-17-6-2-5-16-7-3-13-24-20(16)17/h2-3,5-11,13,21,28-29H,4,12,14-15H2,1H3,(H,25,27)/t21-,23+/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.480 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibitory concentration against TNF-alpha release in LPS treated whole blood |
Bioorg Med Chem Lett 15: 3385-8 (2005)
Article DOI: 10.1016/j.bmcl.2005.05.037
BindingDB Entry DOI: 10.7270/Q25D8RCC |
More data for this
Ligand-Target Pair | |
Collagenase 3
(Homo sapiens (Human)) | BDBM50167611
((2R,5R)-1-[4-(2-Chloro-4-fluoro-benzyloxy)-benzene...)Show SMILES CC1(C)C[C@@H](O)CN([C@H]1C(=O)NO)S(=O)(=O)c1ccc(OCc2ccc(F)cc2Cl)cc1 Show InChI InChI=1S/C21H24ClFN2O6S/c1-21(2)10-15(26)11-25(19(21)20(27)24-28)32(29,30)17-7-5-16(6-8-17)31-12-13-3-4-14(23)9-18(13)22/h3-9,15,19,26,28H,10-12H2,1-2H3,(H,24,27)/t15-,19+/m1/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Groton Laboratories
Curated by ChEMBL
| Assay Description
Inhibitory concentration against Matrix metalloproteinase-13 (MMP-13) |
Bioorg Med Chem Lett 15: 2808-11 (2005)
Article DOI: 10.1016/j.bmcl.2005.03.105
BindingDB Entry DOI: 10.7270/Q2BC3Z24 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM16390
(4-(2,4-difluorophenyl)-5-[3-(1-methylcyclopropyl)-...)Show SMILES CC1(CC1)c1nnc2ccc(cn12)-c1ocnc1-c1ccc(F)cc1F Show InChI InChI=1S/C19H14F2N4O/c1-19(6-7-19)18-24-23-15-5-2-11(9-25(15)18)17-16(22-10-26-17)13-4-3-12(20)8-14(13)21/h2-5,8-10H,6-7H2,1H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 0.700 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer
| Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al... |
Bioorg Med Chem Lett 16: 4339-44 (2006)
Article DOI: 10.1016/j.bmcl.2006.05.056
BindingDB Entry DOI: 10.7270/Q2251GFZ |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM15413
(4-(4-fluorophenyl)-5-[1-(propan-2-yl)-1H-1,2,3-ben...)Show InChI InChI=1S/C18H15FN4O/c1-11(2)23-16-9-13(5-8-15(16)21-22-23)18-17(20-10-24-18)12-3-6-14(19)7-4-12/h3-11H,1-2H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Patents
| Article
PubMed
| n/a | n/a | 0.900 | n/a | n/a | n/a | n/a | 7.2 | 30 |
Pfizer
| Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al... |
J Med Chem 48: 5728-37 (2005)
Article DOI: 10.1021/jm050346q
BindingDB Entry DOI: 10.7270/Q2CR5RMP |
More data for this
Ligand-Target Pair | |
Collagenase 3
(Homo sapiens (Human)) | BDBM50118975
(4-(4-Methoxy-benzenesulfonyl)-1-(thiophene-2-carbo...)Show SMILES COc1ccc(cc1)S(=O)(=O)N1Cc2ccccc2N(CC1C(=O)NO)C(=O)c1cccs1 Show InChI InChI=1S/C22H21N3O6S2/c1-31-16-8-10-17(11-9-16)33(29,30)25-13-15-5-2-3-6-18(15)24(14-19(25)21(26)23-28)22(27)20-7-4-12-32-20/h2-12,19,28H,13-14H2,1H3,(H,23,26) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
In vitro inhibition of matrix metalloprotease-13. |
Bioorg Med Chem Lett 13: 3243-6 (2003)
BindingDB Entry DOI: 10.7270/Q2Q23ZMM |
More data for this
Ligand-Target Pair | |
Neutrophil collagenase
(Homo sapiens (Human)) | BDBM50168737
((2R,3R)-1-[4-(2-Chloro-4-fluoro-benzyloxy)-benzene...)Show SMILES C[C@@]1(O)CCCN([C@H]1C(=O)NO)S(=O)(=O)c1ccc(OCc2ccc(F)cc2Cl)cc1 Show InChI InChI=1S/C20H22ClFN2O6S/c1-20(26)9-2-10-24(18(20)19(25)23-27)31(28,29)16-7-5-15(6-8-16)30-12-13-3-4-14(22)11-17(13)21/h3-8,11,18,26-27H,2,9-10,12H2,1H3,(H,23,25)/t18-,20+/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibitory concentration against MMP-8 |
Bioorg Med Chem Lett 15: 3385-8 (2005)
Article DOI: 10.1016/j.bmcl.2005.05.037
BindingDB Entry DOI: 10.7270/Q25D8RCC |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM16393
(5-{3-tert-butyl-[1,2,4]triazolo[3,4-a]pyridin-6-yl...)Show SMILES CC(C)(C)c1nnc2ccc(cn12)-c1ocnc1-c1ccc(F)cc1F Show InChI InChI=1S/C19H16F2N4O/c1-19(2,3)18-24-23-15-7-4-11(9-25(15)18)17-16(22-10-26-17)13-6-5-12(20)8-14(13)21/h4-10H,1-3H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer
| Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al... |
Bioorg Med Chem Lett 16: 4339-44 (2006)
Article DOI: 10.1016/j.bmcl.2006.05.056
BindingDB Entry DOI: 10.7270/Q2251GFZ |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM16392
(4-(2,4-difluorophenyl)-5-[3-(1-methylcyclobutyl)-[...)Show SMILES CC1(CCC1)c1nnc2ccc(cn12)-c1ocnc1-c1ccc(F)cc1F Show InChI InChI=1S/C20H16F2N4O/c1-20(7-2-8-20)19-25-24-16-6-3-12(10-26(16)19)18-17(23-11-27-18)14-5-4-13(21)9-15(14)22/h3-6,9-11H,2,7-8H2,1H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer
| Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al... |
Bioorg Med Chem Lett 16: 4339-44 (2006)
Article DOI: 10.1016/j.bmcl.2006.05.056
BindingDB Entry DOI: 10.7270/Q2251GFZ |
More data for this
Ligand-Target Pair | |
Collagenase 3
(Homo sapiens (Human)) | BDBM50167619
((2R,5R)-5-Hydroxy-3,3-dimethyl-1-[4-(4-methyl-benz...)Show SMILES Cc1ccc(COc2ccc(cc2)S(=O)(=O)N2C[C@H](O)CC(C)(C)[C@@H]2C(=O)NO)cc1 Show InChI InChI=1S/C22H28N2O6S/c1-15-4-6-16(7-5-15)14-30-18-8-10-19(11-9-18)31(28,29)24-13-17(25)12-22(2,3)20(24)21(26)23-27/h4-11,17,20,25,27H,12-14H2,1-3H3,(H,23,26)/t17-,20+/m1/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Groton Laboratories
Curated by ChEMBL
| Assay Description
Inhibitory concentration against Matrix metalloproteinase-13 (MMP-13) |
Bioorg Med Chem Lett 15: 2808-11 (2005)
Article DOI: 10.1016/j.bmcl.2005.03.105
BindingDB Entry DOI: 10.7270/Q2BC3Z24 |
More data for this
Ligand-Target Pair | |
Collagenase 3
(Homo sapiens (Human)) | BDBM50167618
((2R,5R)-1-[4-(4-Bromo-benzyloxy)-benzenesulfonyl]-...)Show SMILES CC1(C)C[C@@H](O)CN([C@H]1C(=O)NO)S(=O)(=O)c1ccc(OCc2ccc(Br)cc2)cc1 Show InChI InChI=1S/C21H25BrN2O6S/c1-21(2)11-16(25)12-24(19(21)20(26)23-27)31(28,29)18-9-7-17(8-10-18)30-13-14-3-5-15(22)6-4-14/h3-10,16,19,25,27H,11-13H2,1-2H3,(H,23,26)/t16-,19+/m1/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Groton Laboratories
Curated by ChEMBL
| Assay Description
Inhibitory concentration against Matrix metalloproteinase-13 (MMP-13) |
Bioorg Med Chem Lett 15: 2808-11 (2005)
Article DOI: 10.1016/j.bmcl.2005.03.105
BindingDB Entry DOI: 10.7270/Q2BC3Z24 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM16398
(4-(2,5-difluorophenyl)-5-[3-(1-methylcyclobutyl)-[...)Show SMILES CC1(CCC1)c1nnc2ccc(cn12)-c1ocnc1-c1cc(F)ccc1F Show InChI InChI=1S/C20H16F2N4O/c1-20(7-2-8-20)19-25-24-16-6-3-12(10-26(16)19)18-17(23-11-27-18)14-9-13(21)4-5-15(14)22/h3-6,9-11H,2,7-8H2,1H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer
| Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al... |
Bioorg Med Chem Lett 16: 4339-44 (2006)
Article DOI: 10.1016/j.bmcl.2006.05.056
BindingDB Entry DOI: 10.7270/Q2251GFZ |
More data for this
Ligand-Target Pair | |
Disintegrin and metalloproteinase domain-containing protein 17
(Homo sapiens (Human)) | BDBM50168743
((2R,3R)-1-[4-(3-Fluoro-2-methyl-benzyloxy)-benzene...)Show SMILES Cc1c(F)cccc1COc1ccc(cc1)S(=O)(=O)N1CCC[C@@](C)(O)[C@@H]1C(=O)NO Show InChI InChI=1S/C21H25FN2O6S/c1-14-15(5-3-6-18(14)22)13-30-16-7-9-17(10-8-16)31(28,29)24-12-4-11-21(2,26)19(24)20(25)23-27/h3,5-10,19,26-27H,4,11-13H2,1-2H3,(H,23,25)/t19-,21+/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 1.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibitory concentration against TNF-alpha release in LPS treated whole blood |
Bioorg Med Chem Lett 15: 3385-8 (2005)
Article DOI: 10.1016/j.bmcl.2005.05.037
BindingDB Entry DOI: 10.7270/Q25D8RCC |
More data for this
Ligand-Target Pair | |
Disintegrin and metalloproteinase domain-containing protein 17
(Rattus norvegicus) | BDBM50168758
((2R,3S)-3-Ethyl-1-[4-(4-fluoro-benzyloxy)-benzenes...)Show SMILES CC[C@]1(O)CCCN([C@H]1C(=O)NO)S(=O)(=O)c1ccc(OCc2ccc(F)cc2)cc1 Show InChI InChI=1S/C21H25FN2O6S/c1-2-21(26)12-3-13-24(19(21)20(25)23-27)31(28,29)18-10-8-17(9-11-18)30-14-15-4-6-16(22)7-5-15/h4-11,19,26-27H,2-3,12-14H2,1H3,(H,23,25)/t19-,21-/m0/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 1.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibitory concentration of the compound against rat TACE |
Bioorg Med Chem Lett 15: 3385-8 (2005)
Article DOI: 10.1016/j.bmcl.2005.05.037
BindingDB Entry DOI: 10.7270/Q25D8RCC |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM16404
(5-{3-tert-butyl-[1,2,4]triazolo[3,4-a]pyridin-6-yl...)Show SMILES CC(C)(C)c1nnc2ccc(cn12)-c1ocnc1-c1cc(F)c(F)cc1F Show InChI InChI=1S/C19H15F3N4O/c1-19(2,3)18-25-24-15-5-4-10(8-26(15)18)17-16(23-9-27-17)11-6-13(21)14(22)7-12(11)20/h4-9H,1-3H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 1.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer
| Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al... |
Bioorg Med Chem Lett 16: 4339-44 (2006)
Article DOI: 10.1016/j.bmcl.2006.05.056
BindingDB Entry DOI: 10.7270/Q2251GFZ |
More data for this
Ligand-Target Pair | |
Disintegrin and metalloproteinase domain-containing protein 17
(Homo sapiens (Human)) | BDBM50168738
((2R,3R)-1-[4-(5-Fluoro-2-methyl-benzyloxy)-benzene...)Show SMILES Cc1ccc(F)cc1COc1ccc(cc1)S(=O)(=O)N1CCC[C@@](C)(O)[C@@H]1C(=O)NO Show InChI InChI=1S/C21H25FN2O6S/c1-14-4-5-16(22)12-15(14)13-30-17-6-8-18(9-7-17)31(28,29)24-11-3-10-21(2,26)19(24)20(25)23-27/h4-9,12,19,26-27H,3,10-11,13H2,1-2H3,(H,23,25)/t19-,21+/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 1.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibitory concentration against TNF-alpha release in LPS treated whole blood |
Bioorg Med Chem Lett 15: 3385-8 (2005)
Article DOI: 10.1016/j.bmcl.2005.05.037
BindingDB Entry DOI: 10.7270/Q25D8RCC |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM15459
(4-[1-methyl-2-(piperidin-4-yl)-4-[3-(trifluorometh...)Show SMILES C[C@H](Nc1cc(ccn1)-c1c(nc(C2CCNCC2)n1C)-c1cccc(c1)C(F)(F)F)c1ccccc1 |r| Show InChI InChI=1S/C29H30F3N5/c1-19(20-7-4-3-5-8-20)35-25-18-23(13-16-34-25)27-26(22-9-6-10-24(17-22)29(30,31)32)36-28(37(27)2)21-11-14-33-15-12-21/h3-10,13,16-19,21,33H,11-12,14-15H2,1-2H3,(H,34,35)/t19-/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer
| Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al... |
Bioorg Med Chem Lett 14: 919-23 (2004)
Article DOI: 10.1016/j.bmcl.2003.12.023
BindingDB Entry DOI: 10.7270/Q28050V6 |
More data for this
Ligand-Target Pair | 
3D Structure (docked) |
Collagenase 3
(Homo sapiens (Human)) | BDBM50167620
((2R,5R)-1-[4-(5-Fluoro-2-methyl-benzyloxy)-benzene...)Show SMILES Cc1ccc(F)cc1COc1ccc(cc1)S(=O)(=O)N1C[C@H](O)CC[C@@H]1C(=O)NO Show InChI InChI=1S/C20H23FN2O6S/c1-13-2-3-15(21)10-14(13)12-29-17-5-7-18(8-6-17)30(27,28)23-11-16(24)4-9-19(23)20(25)22-26/h2-3,5-8,10,16,19,24,26H,4,9,11-12H2,1H3,(H,22,25)/t16-,19-/m1/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 2.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Groton Laboratories
Curated by ChEMBL
| Assay Description
Inhibitory concentration against Matrix metalloproteinase-13 (MMP-13) |
Bioorg Med Chem Lett 15: 2808-11 (2005)
Article DOI: 10.1016/j.bmcl.2005.03.105
BindingDB Entry DOI: 10.7270/Q2BC3Z24 |
More data for this
Ligand-Target Pair | |
Disintegrin and metalloproteinase domain-containing protein 17
(Homo sapiens (Human)) | BDBM50168752
((2R,3R)-3-Hydroxy-3-methyl-1-[4-(2-methyl-benzylox...)Show SMILES Cc1ccccc1COc1ccc(cc1)S(=O)(=O)N1CCC[C@@](C)(O)[C@@H]1C(=O)NO Show InChI InChI=1S/C21H26N2O6S/c1-15-6-3-4-7-16(15)14-29-17-8-10-18(11-9-17)30(27,28)23-13-5-12-21(2,25)19(23)20(24)22-26/h3-4,6-11,19,25-26H,5,12-14H2,1-2H3,(H,22,24)/t19-,21+/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 2.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibitory concentration against TNF-alpha release in LPS treated whole blood |
Bioorg Med Chem Lett 15: 3385-8 (2005)
Article DOI: 10.1016/j.bmcl.2005.05.037
BindingDB Entry DOI: 10.7270/Q25D8RCC |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM16346
(4-(4-chloro-2-fluorophenyl)-5-[3-(propan-2-yl)-[1,...)Show InChI InChI=1S/C18H14ClFN4O/c1-10(2)18-23-22-15-6-3-11(8-24(15)18)17-16(21-9-25-17)13-5-4-12(19)7-14(13)20/h3-10H,1-2H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.20 | n/a | n/a | n/a | n/a | 7.2 | 30 |
Pfizer
| Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al... |
Bioorg Med Chem Lett 16: 4339-44 (2006)
Article DOI: 10.1016/j.bmcl.2006.05.056
BindingDB Entry DOI: 10.7270/Q2251GFZ |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM16401
(5-[3-(1-methylcyclopropyl)-[1,2,4]triazolo[3,4-a]p...)Show SMILES CC1(CC1)c1nnc2ccc(cn12)-c1ocnc1-c1cc(F)c(F)cc1F Show InChI InChI=1S/C19H13F3N4O/c1-19(4-5-19)18-25-24-15-3-2-10(8-26(15)18)17-16(23-9-27-17)11-6-13(21)14(22)7-12(11)20/h2-3,6-9H,4-5H2,1H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 2.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer
| Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al... |
Bioorg Med Chem Lett 16: 4339-44 (2006)
Article DOI: 10.1016/j.bmcl.2006.05.056
BindingDB Entry DOI: 10.7270/Q2251GFZ |
More data for this
Ligand-Target Pair | |
Disintegrin and metalloproteinase domain-containing protein 17
(Homo sapiens (Human)) | BDBM50168741
((2R,3R)-1-[4-(4-Fluoro-2-methyl-benzyloxy)-benzene...)Show SMILES Cc1cc(F)ccc1COc1ccc(cc1)S(=O)(=O)N1CCC[C@@](C)(O)[C@@H]1C(=O)NO Show InChI InChI=1S/C21H25FN2O6S/c1-14-12-16(22)5-4-15(14)13-30-17-6-8-18(9-7-17)31(28,29)24-11-3-10-21(2,26)19(24)20(25)23-27/h4-9,12,19,26-27H,3,10-11,13H2,1-2H3,(H,23,25)/t19-,21+/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 2.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibitory concentration against TNF-alpha release in LPS treated whole blood |
Bioorg Med Chem Lett 15: 3385-8 (2005)
Article DOI: 10.1016/j.bmcl.2005.05.037
BindingDB Entry DOI: 10.7270/Q25D8RCC |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM16403
(5-[3-(1-methylcyclobutyl)-[1,2,4]triazolo[3,4-a]py...)Show SMILES CC1(CCC1)c1nnc2ccc(cn12)-c1ocnc1-c1cc(F)c(F)cc1F Show InChI InChI=1S/C20H15F3N4O/c1-20(5-2-6-20)19-26-25-16-4-3-11(9-27(16)19)18-17(24-10-28-18)12-7-14(22)15(23)8-13(12)21/h3-4,7-10H,2,5-6H2,1H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer
| Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al... |
Bioorg Med Chem Lett 16: 4339-44 (2006)
Article DOI: 10.1016/j.bmcl.2006.05.056
BindingDB Entry DOI: 10.7270/Q2251GFZ |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM16348
(4-(2-chloro-4-fluorophenyl)-5-[3-(propan-2-yl)-[1,...)Show InChI InChI=1S/C18H14ClFN4O/c1-10(2)18-23-22-15-6-3-11(8-24(15)18)17-16(21-9-25-17)13-5-4-12(20)7-14(13)19/h3-10H,1-2H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer
| Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al... |
Bioorg Med Chem Lett 16: 4339-44 (2006)
Article DOI: 10.1016/j.bmcl.2006.05.056
BindingDB Entry DOI: 10.7270/Q2251GFZ |
More data for this
Ligand-Target Pair | |
Disintegrin and metalloproteinase domain-containing protein 17
(Homo sapiens (Human)) | BDBM50168756
((2R,3R)-3-Hydroxy-1-[4-(isoquinolin-8-ylmethoxy)-b...)Show SMILES C[C@@]1(O)CCCN([C@H]1C(=O)NO)S(=O)(=O)c1ccc(OCc2cccc3ccncc23)cc1 Show InChI InChI=1S/C23H25N3O6S/c1-23(28)11-3-13-26(21(23)22(27)25-29)33(30,31)19-8-6-18(7-9-19)32-15-17-5-2-4-16-10-12-24-14-20(16)17/h2,4-10,12,14,21,28-29H,3,11,13,15H2,1H3,(H,25,27)/t21-,23+/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibitory concentration against TNF-alpha release in LPS treated whole blood |
Bioorg Med Chem Lett 15: 3385-8 (2005)
Article DOI: 10.1016/j.bmcl.2005.05.037
BindingDB Entry DOI: 10.7270/Q25D8RCC |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM16405
(3-(2,5-difluorophenyl)-4-[3-(propan-2-yl)-[1,2,4]t...)Show SMILES CC(C)c1nnc2ccc(cn12)-c1c[nH]nc1-c1cc(F)ccc1F Show InChI InChI=1S/C18H15F2N5/c1-10(2)18-24-22-16-6-3-11(9-25(16)18)14-8-21-23-17(14)13-7-12(19)4-5-15(13)20/h3-10H,1-2H3,(H,21,23) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 2.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer
| Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al... |
Bioorg Med Chem Lett 16: 4339-44 (2006)
Article DOI: 10.1016/j.bmcl.2006.05.056
BindingDB Entry DOI: 10.7270/Q2251GFZ |
More data for this
Ligand-Target Pair | |
Collagenase 3
(Homo sapiens (Human)) | BDBM50167621
((2R,5R)-5-Hydroxy-3,3-dimethyl-1-[4-(3-methyl-benz...)Show SMILES Cc1cccc(COc2ccc(cc2)S(=O)(=O)N2C[C@H](O)CC(C)(C)[C@@H]2C(=O)NO)c1 Show InChI InChI=1S/C22H28N2O6S/c1-15-5-4-6-16(11-15)14-30-18-7-9-19(10-8-18)31(28,29)24-13-17(25)12-22(2,3)20(24)21(26)23-27/h4-11,17,20,25,27H,12-14H2,1-3H3,(H,23,26)/t17-,20+/m1/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Groton Laboratories
Curated by ChEMBL
| Assay Description
Inhibitory concentration against Matrix metalloproteinase-13 (MMP-13) |
Bioorg Med Chem Lett 15: 2808-11 (2005)
Article DOI: 10.1016/j.bmcl.2005.03.105
BindingDB Entry DOI: 10.7270/Q2BC3Z24 |
More data for this
Ligand-Target Pair | |
Collagenase 3
(Homo sapiens (Human)) | BDBM50167609
((2R,5R)-1-[4-(2,4-Dichloro-benzyloxy)-benzenesulfo...)Show SMILES CC1(C)C[C@@H](O)CN([C@H]1C(=O)NO)S(=O)(=O)c1ccc(OCc2ccc(Cl)cc2Cl)cc1 Show InChI InChI=1S/C21H24Cl2N2O6S/c1-21(2)10-15(26)11-25(19(21)20(27)24-28)32(29,30)17-7-5-16(6-8-17)31-12-13-3-4-14(22)9-18(13)23/h3-9,15,19,26,28H,10-12H2,1-2H3,(H,24,27)/t15-,19+/m1/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Groton Laboratories
Curated by ChEMBL
| Assay Description
Inhibitory concentration against Matrix metalloproteinase-13 (MMP-13) |
Bioorg Med Chem Lett 15: 2808-11 (2005)
Article DOI: 10.1016/j.bmcl.2005.03.105
BindingDB Entry DOI: 10.7270/Q2BC3Z24 |
More data for this
Ligand-Target Pair | |
Collagenase 3
(Homo sapiens (Human)) | BDBM50132632
((2R,3S)-4-Acetyl-3-methyl-1-[4-(2-methyl-benzyloxy...)Show SMILES C[C@H]1[C@@H](N(CCN1C(C)=O)S(=O)(=O)c1ccc(OCc2ccccc2C)cc1)C(=O)NO Show InChI InChI=1S/C22H27N3O6S/c1-15-6-4-5-7-18(15)14-31-19-8-10-20(11-9-19)32(29,30)25-13-12-24(17(3)26)16(2)21(25)22(27)23-28/h4-11,16,21,28H,12-14H2,1-3H3,(H,23,27)/t16-,21+/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
In vitro inhibition of matrix metalloprotease-13. |
Bioorg Med Chem Lett 13: 3243-6 (2003)
BindingDB Entry DOI: 10.7270/Q2Q23ZMM |
More data for this
Ligand-Target Pair | |
Collagenase 3
(Homo sapiens (Human)) | BDBM50132620
((2R,3S)-4-Acetyl-1-[4-(4-fluoro-benzyloxy)-benzene...)Show SMILES C[C@H]1[C@@H](N(CCN1C(C)=O)S(=O)(=O)c1ccc(OCc2ccc(F)cc2)cc1)C(=O)NO Show InChI InChI=1S/C21H24FN3O6S/c1-14-20(21(27)23-28)25(12-11-24(14)15(2)26)32(29,30)19-9-7-18(8-10-19)31-13-16-3-5-17(22)6-4-16/h3-10,14,20,28H,11-13H2,1-2H3,(H,23,27)/t14-,20+/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
In vitro inhibition of matrix metalloprotease-13. |
Bioorg Med Chem Lett 13: 3243-6 (2003)
BindingDB Entry DOI: 10.7270/Q2Q23ZMM |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM16340
(4-(2-chlorophenyl)-5-[3-(propan-2-yl)-[1,2,4]triaz...)Show InChI InChI=1S/C18H15ClN4O/c1-11(2)18-22-21-15-8-7-12(9-23(15)18)17-16(20-10-24-17)13-5-3-4-6-14(13)19/h3-11H,1-2H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | 7.2 | 30 |
Pfizer
| Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al... |
Bioorg Med Chem Lett 16: 4339-44 (2006)
Article DOI: 10.1016/j.bmcl.2006.05.056
BindingDB Entry DOI: 10.7270/Q2251GFZ |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM16396
(4-(2,5-difluorophenyl)-5-[3-(1-methylcyclopropyl)-...)Show SMILES CC1(CC1)c1nnc2ccc(cn12)-c1ocnc1-c1cc(F)ccc1F Show InChI InChI=1S/C19H14F2N4O/c1-19(6-7-19)18-24-23-15-5-2-11(9-25(15)18)17-16(22-10-26-17)13-8-12(20)3-4-14(13)21/h2-5,8-10H,6-7H2,1H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer
| Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al... |
Bioorg Med Chem Lett 16: 4339-44 (2006)
Article DOI: 10.1016/j.bmcl.2006.05.056
BindingDB Entry DOI: 10.7270/Q2251GFZ |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM16351
(5-[3-(propan-2-yl)-[1,2,4]triazolo[3,4-a]pyridin-6...)Show SMILES CC(C)c1nnc2ccc(cn12)-c1ocnc1-c1cc(F)c(F)cc1F Show InChI InChI=1S/C18H13F3N4O/c1-9(2)18-24-23-15-4-3-10(7-25(15)18)17-16(22-8-26-17)11-5-13(20)14(21)6-12(11)19/h3-9H,1-2H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 3.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer
| Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al... |
Bioorg Med Chem Lett 16: 4339-44 (2006)
Article DOI: 10.1016/j.bmcl.2006.05.056
BindingDB Entry DOI: 10.7270/Q2251GFZ |
More data for this
Ligand-Target Pair | |
Disintegrin and metalloproteinase domain-containing protein 17
(Homo sapiens (Human)) | BDBM50168747
((2R,3R)-3-Hydroxy-3-methyl-1-[4-(2-methyl-pyridin-...)Show SMILES Cc1ncccc1COc1ccc(cc1)S(=O)(=O)N1CCC[C@@](C)(O)[C@@H]1C(=O)NO Show InChI InChI=1S/C20H25N3O6S/c1-14-15(5-3-11-21-14)13-29-16-6-8-17(9-7-16)30(27,28)23-12-4-10-20(2,25)18(23)19(24)22-26/h3,5-9,11,18,25-26H,4,10,12-13H2,1-2H3,(H,22,24)/t18-,20+/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibitory concentration against TNF-alpha release in LPS treated whole blood |
Bioorg Med Chem Lett 15: 3385-8 (2005)
Article DOI: 10.1016/j.bmcl.2005.05.037
BindingDB Entry DOI: 10.7270/Q25D8RCC |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM16386
(5-{3-tert-butyl-[1,2,4]triazolo[3,4-a]pyridin-6-yl...)Show SMILES CC(C)(C)c1nnc2ccc(cn12)-c1ocnc1-c1ccc(F)cc1 Show InChI InChI=1S/C19H17FN4O/c1-19(2,3)18-23-22-15-9-6-13(10-24(15)18)17-16(21-11-25-17)12-4-7-14(20)8-5-12/h4-11H,1-3H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer
| Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al... |
Bioorg Med Chem Lett 16: 4339-44 (2006)
Article DOI: 10.1016/j.bmcl.2006.05.056
BindingDB Entry DOI: 10.7270/Q2251GFZ |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM16389
(5-{3-cyclopropyl-[1,2,4]triazolo[3,4-a]pyridin-6-y...)Show SMILES Fc1ccc(-c2ncoc2-c2ccc3nnc(C4CC4)n3c2)c(F)c1 Show InChI InChI=1S/C18H12F2N4O/c19-12-4-5-13(14(20)7-12)16-17(25-9-21-16)11-3-6-15-22-23-18(10-1-2-10)24(15)8-11/h3-10H,1-2H2 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 3.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer
| Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al... |
Bioorg Med Chem Lett 16: 4339-44 (2006)
Article DOI: 10.1016/j.bmcl.2006.05.056
BindingDB Entry DOI: 10.7270/Q2251GFZ |
More data for this
Ligand-Target Pair | |
Collagenase 3
(Homo sapiens (Human)) | BDBM50167605
((2R,5R)-1-[4-(4-Fluoro-2-methyl-benzyloxy)-benzene...)Show SMILES Cc1cc(F)ccc1COc1ccc(cc1)S(=O)(=O)N1C[C@H](O)CC(C)(C)[C@@H]1C(=O)NO Show InChI InChI=1S/C22H27FN2O6S/c1-14-10-16(23)5-4-15(14)13-31-18-6-8-19(9-7-18)32(29,30)25-12-17(26)11-22(2,3)20(25)21(27)24-28/h4-10,17,20,26,28H,11-13H2,1-3H3,(H,24,27)/t17-,20+/m1/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 3.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Groton Laboratories
Curated by ChEMBL
| Assay Description
Inhibitory concentration against Matrix metalloproteinase-13 (MMP-13) |
Bioorg Med Chem Lett 15: 2808-11 (2005)
Article DOI: 10.1016/j.bmcl.2005.03.105
BindingDB Entry DOI: 10.7270/Q2BC3Z24 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM16391
(5-{3-cyclobutyl-[1,2,4]triazolo[3,4-a]pyridin-6-yl...)Show SMILES Fc1ccc(-c2ncoc2-c2ccc3nnc(C4CCC4)n3c2)c(F)c1 Show InChI InChI=1S/C19H14F2N4O/c20-13-5-6-14(15(21)8-13)17-18(26-10-22-17)12-4-7-16-23-24-19(25(16)9-12)11-2-1-3-11/h4-11H,1-3H2 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.75 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer
| Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al... |
Bioorg Med Chem Lett 16: 4339-44 (2006)
Article DOI: 10.1016/j.bmcl.2006.05.056
BindingDB Entry DOI: 10.7270/Q2251GFZ |
More data for this
Ligand-Target Pair | |
Collagenase 3
(Homo sapiens (Human)) | BDBM50132625
((2S,3R)-3-Hydroxycarbamoyl-2-methyl-4-[4-(2-methyl...)Show SMILES COC(=O)N1CCN([C@H]([C@@H]1C)C(=O)NO)S(=O)(=O)c1ccc(OCc2ccccc2C)cc1 Show InChI InChI=1S/C22H27N3O7S/c1-15-6-4-5-7-17(15)14-32-18-8-10-19(11-9-18)33(29,30)25-13-12-24(22(27)31-3)16(2)20(25)21(26)23-28/h4-11,16,20,28H,12-14H2,1-3H3,(H,23,26)/t16-,20+/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
In vitro inhibition of matrix metalloprotease-13. |
Bioorg Med Chem Lett 13: 3243-6 (2003)
BindingDB Entry DOI: 10.7270/Q2Q23ZMM |
More data for this
Ligand-Target Pair | |
Collagenase 3
(Homo sapiens (Human)) | BDBM50132628
((2R,3S)-4-Methanesulfonyl-3-methyl-1-[4-(2-methyl-...)Show SMILES C[C@H]1[C@@H](N(CCN1S(C)(=O)=O)S(=O)(=O)c1ccc(OCc2ccccc2C)cc1)C(=O)NO Show InChI InChI=1S/C21H27N3O7S2/c1-15-6-4-5-7-17(15)14-31-18-8-10-19(11-9-18)33(29,30)24-13-12-23(32(3,27)28)16(2)20(24)21(25)22-26/h4-11,16,20,26H,12-14H2,1-3H3,(H,22,25)/t16-,20+/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
In vitro inhibition of matrix metalloprotease-13. |
Bioorg Med Chem Lett 13: 3243-6 (2003)
BindingDB Entry DOI: 10.7270/Q2Q23ZMM |
More data for this
Ligand-Target Pair | |
Collagenase 3
(Homo sapiens (Human)) | BDBM50132638
((2S,3R)-2-Methyl-4-[4-(2-methyl-benzyloxy)-benzene...)Show SMILES CC(C)NC(=O)N1CCN([C@H]([C@@H]1C)C(=O)NO)S(=O)(=O)c1ccc(OCc2ccccc2C)cc1 Show InChI InChI=1S/C24H32N4O6S/c1-16(2)25-24(30)27-13-14-28(22(18(27)4)23(29)26-31)35(32,33)21-11-9-20(10-12-21)34-15-19-8-6-5-7-17(19)3/h5-12,16,18,22,31H,13-15H2,1-4H3,(H,25,30)(H,26,29)/t18-,22+/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
In vitro inhibition of matrix metalloprotease-13. |
Bioorg Med Chem Lett 13: 3243-6 (2003)
BindingDB Entry DOI: 10.7270/Q2Q23ZMM |
More data for this
Ligand-Target Pair | |
72 kDa type IV collagenase
(Homo sapiens (Human)) | BDBM50168737
((2R,3R)-1-[4-(2-Chloro-4-fluoro-benzyloxy)-benzene...)Show SMILES C[C@@]1(O)CCCN([C@H]1C(=O)NO)S(=O)(=O)c1ccc(OCc2ccc(F)cc2Cl)cc1 Show InChI InChI=1S/C20H22ClFN2O6S/c1-20(26)9-2-10-24(18(20)19(25)23-27)31(28,29)16-7-5-15(6-8-16)30-12-13-3-4-14(22)11-17(13)21/h3-8,11,18,26-27H,2,9-10,12H2,1H3,(H,23,25)/t18-,20+/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibitory concentration against MMP-2 |
Bioorg Med Chem Lett 15: 3385-8 (2005)
Article DOI: 10.1016/j.bmcl.2005.05.037
BindingDB Entry DOI: 10.7270/Q25D8RCC |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM16350
(5-[3-(propan-2-yl)-[1,2,4]triazolo[3,4-a]pyridin-6...)Show SMILES CC(C)c1nnc2ccc(cn12)-c1ocnc1-c1cc(F)c(F)c(F)c1 Show InChI InChI=1S/C18H13F3N4O/c1-9(2)18-24-23-14-4-3-10(7-25(14)18)17-16(22-8-26-17)11-5-12(19)15(21)13(20)6-11/h3-9H,1-2H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 4.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer
| Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al... |
Bioorg Med Chem Lett 16: 4339-44 (2006)
Article DOI: 10.1016/j.bmcl.2006.05.056
BindingDB Entry DOI: 10.7270/Q2251GFZ |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM16337
(4-(2-fluoro-5-methylphenyl)-5-[3-(propan-2-yl)-[1,...)Show InChI InChI=1S/C19H17FN4O/c1-11(2)19-23-22-16-7-5-13(9-24(16)19)18-17(21-10-25-18)14-8-12(3)4-6-15(14)20/h4-11H,1-3H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 4.30 | n/a | n/a | n/a | n/a | 7.2 | 30 |
Pfizer
| Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al... |
Bioorg Med Chem Lett 16: 4339-44 (2006)
Article DOI: 10.1016/j.bmcl.2006.05.056
BindingDB Entry DOI: 10.7270/Q2251GFZ |
More data for this
Ligand-Target Pair | |
Collagenase 3
(Homo sapiens (Human)) | BDBM50167617
((2R,5R)-1-[4-(3-Fluoro-2-methyl-benzyloxy)-benzene...)Show SMILES Cc1c(F)cccc1COc1ccc(cc1)S(=O)(=O)N1C[C@H](O)CC(C)(C)[C@@H]1C(=O)NO Show InChI InChI=1S/C22H27FN2O6S/c1-14-15(5-4-6-19(14)23)13-31-17-7-9-18(10-8-17)32(29,30)25-12-16(26)11-22(2,3)20(25)21(27)24-28/h4-10,16,20,26,28H,11-13H2,1-3H3,(H,24,27)/t16-,20+/m1/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 4.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Groton Laboratories
Curated by ChEMBL
| Assay Description
Inhibitory concentration against Matrix metalloproteinase-13 (MMP-13) |
Bioorg Med Chem Lett 15: 2808-11 (2005)
Article DOI: 10.1016/j.bmcl.2005.03.105
BindingDB Entry DOI: 10.7270/Q2BC3Z24 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM16341
(4-(2,4-difluorophenyl)-5-[3-(propan-2-yl)-[1,2,4]t...)Show InChI InChI=1S/C18H14F2N4O/c1-10(2)18-23-22-15-6-3-11(8-24(15)18)17-16(21-9-25-17)13-5-4-12(19)7-14(13)20/h3-10H,1-2H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4.60 | n/a | n/a | n/a | n/a | 7.2 | 30 |
Pfizer
| Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al... |
Bioorg Med Chem Lett 16: 4339-44 (2006)
Article DOI: 10.1016/j.bmcl.2006.05.056
BindingDB Entry DOI: 10.7270/Q2251GFZ |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM16379
(N-ethyl-6-[4-(4-fluorophenyl)-1,3-oxazol-5-yl]-N-m...)Show InChI InChI=1S/C18H16FN5O/c1-3-23(2)18-22-21-15-9-6-13(10-24(15)18)17-16(20-11-25-17)12-4-7-14(19)8-5-12/h4-11H,3H2,1-2H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer
| Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al... |
Bioorg Med Chem Lett 16: 4339-44 (2006)
Article DOI: 10.1016/j.bmcl.2006.05.056
BindingDB Entry DOI: 10.7270/Q2251GFZ |
More data for this
Ligand-Target Pair | |
Stromelysin-1
(Homo sapiens (Human)) | BDBM50168737
((2R,3R)-1-[4-(2-Chloro-4-fluoro-benzyloxy)-benzene...)Show SMILES C[C@@]1(O)CCCN([C@H]1C(=O)NO)S(=O)(=O)c1ccc(OCc2ccc(F)cc2Cl)cc1 Show InChI InChI=1S/C20H22ClFN2O6S/c1-20(26)9-2-10-24(18(20)19(25)23-27)31(28,29)16-7-5-15(6-8-16)30-12-13-3-4-14(22)11-17(13)21/h3-8,11,18,26-27H,2,9-10,12H2,1H3,(H,23,25)/t18-,20+/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibitory concentration against MMP-3 |
Bioorg Med Chem Lett 15: 3385-8 (2005)
Article DOI: 10.1016/j.bmcl.2005.05.037
BindingDB Entry DOI: 10.7270/Q25D8RCC |
More data for this
Ligand-Target Pair | |
Disintegrin and metalloproteinase domain-containing protein 17
(Homo sapiens (Human)) | BDBM50113041
((2R,5R)-5-Hydroxy-1-[4-(2-trifluoromethyl-benzylox...)Show SMILES ONC(=O)[C@H]1CC[C@@H](O)CN1S(=O)(=O)c1ccc(OCc2ccccc2C(F)(F)F)cc1 Show InChI InChI=1S/C20H21F3N2O6S/c21-20(22,23)17-4-2-1-3-13(17)12-31-15-6-8-16(9-7-15)32(29,30)25-11-14(26)5-10-18(25)19(27)24-28/h1-4,6-9,14,18,26,28H,5,10-12H2,(H,24,27)/t14-,18-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibitory concentration against recombinant tumor necrosis factor alpha converting enzyme |
Bioorg Med Chem Lett 12: 1387-90 (2002)
BindingDB Entry DOI: 10.7270/Q2GQ6X30 |
More data for this
Ligand-Target Pair | |
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