Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Adenosine deaminase (Bos taurus (bovine)) | BDBM50370598 (CHEMBL1651379) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.0530 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Pisa Curated by ChEMBL | Assay Description Inhibitory constant against bovine spleen Adenosine deaminase | J Med Chem 48: 5162-74 (2005) Article DOI: 10.1021/jm050136d BindingDB Entry DOI: 10.7270/Q2542PCH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine deaminase (Bos taurus (bovine)) | BDBM50171394 (2-Decyl-2H-pyrazolo[3,4-d]pyrimidin-4-ylamine | CH...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.130 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Pisa Curated by ChEMBL | Assay Description Inhibitory constant against bovine spleen Adenosine deaminase | J Med Chem 48: 5162-74 (2005) Article DOI: 10.1021/jm050136d BindingDB Entry DOI: 10.7270/Q2542PCH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Translocator protein (Rattus norvegicus (rat)) | BDBM50253857 (CHEMBL460998 | N-butyl-2-(5-chloro-2-(4-chlorophen...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.150 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Pisa Curated by ChEMBL | Assay Description Displacement of [3H]PK11195 from translocator protein in rat kidney mitochondrial membrane | J Med Chem 51: 5798-806 (2008) Article DOI: 10.1021/jm8003224 BindingDB Entry DOI: 10.7270/Q2GF0VD5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A3 (Homo sapiens (Human)) | BDBM50318267 (4-methoxy-N-(2-methyl-6-phenyl-2H-pyrazolo[3,4-d]p...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.180 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Pisa Curated by ChEMBL | Assay Description Displacement of [125I]AB-MECA from human adenosine A3 receptor expressed in CHO cells | J Med Chem 53: 3954-63 (2010) Article DOI: 10.1021/jm901785w BindingDB Entry DOI: 10.7270/Q2N017HH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Translocator protein (Rattus norvegicus (rat)) | BDBM50253893 (2-(5-chloro-2-(4-chlorophenyl)-1H-indol-3-yl)-N-me...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.180 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Pisa Curated by ChEMBL | Assay Description Displacement of [3H]PK11195 from translocator protein in rat kidney mitochondrial membrane | J Med Chem 51: 5798-806 (2008) Article DOI: 10.1021/jm8003224 BindingDB Entry DOI: 10.7270/Q2GF0VD5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A3 (Homo sapiens (Human)) | BDBM21221 ((2S,3S,4R,5R)-5-(2-chloro-6-{[(3-iodophenyl)methyl...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | 0.220 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universita di Napoli | Assay Description The membranes prepared from CHO cells transfected with human adenosine A3 receptors were used in binding assays. Nonspecific binding was determined i... | J Med Chem 51: 1764-70 (2008) Article DOI: 10.1021/jm701159t BindingDB Entry DOI: 10.7270/Q2MP51JK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A3 (Homo sapiens (Human)) | BDBM21221 ((2S,3S,4R,5R)-5-(2-chloro-6-{[(3-iodophenyl)methyl...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | 0.220 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Pisa Curated by ChEMBL | Assay Description Displacement of [125I]AB-MECA from human A3 adenosine receptor expressed in CHO cell membrane | J Med Chem 55: 1490-9 (2012) Article DOI: 10.1021/jm201177b BindingDB Entry DOI: 10.7270/Q2CR5VCS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A3 (Homo sapiens (Human)) | BDBM198126 ((2S,3S,4R,5R)-5-[2-chloro-6-[(3-iodophenyl)methyla...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | 0.220 | -55.1 | n/a | n/a | n/a | n/a | n/a | 7.4 | 25 |
Università di Napoli Federico II | Assay Description Aliquots of cell membranes (90 ug) were incubated at 25 °C for 180 min in 500 uL of binding buffer (50 mM Tris-HCl, 5 mM MgCl2, 1 mM EDTA, 2 un... | Chem Biol Drug Des 88: 724-729 (2016) Article DOI: 10.1111/cbdd.12801 BindingDB Entry DOI: 10.7270/Q25M64JG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A3 (Homo sapiens (Human)) | BDBM21221 ((2S,3S,4R,5R)-5-(2-chloro-6-{[(3-iodophenyl)methyl...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | 0.220 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Pisa Curated by ChEMBL | Assay Description Displacement of [3H]AB-MECA from human adenosine A3 receptor expressed in CHO cells | J Med Chem 50: 5676-84 (2007) Article DOI: 10.1021/jm0708376 BindingDB Entry DOI: 10.7270/Q2SJ1MFX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A3 (Homo sapiens (Human)) | BDBM21221 ((2S,3S,4R,5R)-5-(2-chloro-6-{[(3-iodophenyl)methyl...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | 0.220 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Pisa Curated by ChEMBL | Assay Description Displacement of [125I]AB-MECA from human adenosine A3 receptor expressed in CHO cell membrane after 90 mins | Eur J Med Chem 69: 331-7 (2013) Article DOI: 10.1016/j.ejmech.2013.09.001 BindingDB Entry DOI: 10.7270/Q28918TN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Translocator protein (Rattus norvegicus (rat)) | BDBM50253483 (CHEMBL492686 | N,N-dihexyl-2-(2-(4-nitrophenyl)-1H...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.230 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Pisa Curated by ChEMBL | Assay Description Displacement of [3H]PK11195 from translocator protein in rat kidney mitochondrial membrane | J Med Chem 51: 5798-806 (2008) Article DOI: 10.1021/jm8003224 BindingDB Entry DOI: 10.7270/Q2GF0VD5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Translocator protein (Rattus norvegicus (rat)) | BDBM50011484 (CHEMBL3261894) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.235 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Salerno Curated by ChEMBL | Assay Description Displacement of [3H]PK11195 from TSPO in rat kidney mitochondrial membranes | J Med Chem 57: 2413-28 (2014) Article DOI: 10.1021/jm401721h BindingDB Entry DOI: 10.7270/Q2416ZKP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Translocator protein (Rattus norvegicus (rat)) | BDBM50253344 (CHEMBL493301 | N,N-dibutyl-2-(2-(4-nitrophenyl)-1H...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.270 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Pisa Curated by ChEMBL | Assay Description Displacement of [3H]PK11195 from translocator protein in rat kidney mitochondrial membrane | J Med Chem 51: 5798-806 (2008) Article DOI: 10.1021/jm8003224 BindingDB Entry DOI: 10.7270/Q2GF0VD5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine deaminase (Bos taurus (bovine)) | BDBM50171396 (1-((R)-4-Amino-pyrazolo[3,4-d]pyrimidin-2-yl)-deca...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.280 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Pisa Curated by ChEMBL | Assay Description Inhibitory constant against bovine spleen Adenosine deaminase | J Med Chem 48: 5162-74 (2005) Article DOI: 10.1021/jm050136d BindingDB Entry DOI: 10.7270/Q2542PCH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Translocator protein (Homo sapiens (Human)) | BDBM50421116 (CHEMBL2088374) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.280 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Citation and Details Article DOI: 10.1016/j.ejmech.2020.112924 BindingDB Entry DOI: 10.7270/Q25D8WSD | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Translocator protein (Rattus norvegicus (rat)) | BDBM50335260 (CHEMBL1651226 | N,N-dihexyl-2-(1-methyl-2-phenyl-1...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.299 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Mental Health Curated by ChEMBL | Assay Description Displacement of [11C]PK11195 from TSPO in rat kidney mitochondrial membrane | J Med Chem 54: 366-73 (2011) Article DOI: 10.1021/jm101230g BindingDB Entry DOI: 10.7270/Q2ZC83T4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Translocator protein (Rattus norvegicus (rat)) | BDBM50335259 (CHEMBL1651225 | N,N-dibutyl-2-(1-methyl-2-phenyl-1...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.300 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Mental Health Curated by ChEMBL | Assay Description Displacement of [11C]PK11195 from TSPO in rat kidney mitochondrial membrane | J Med Chem 54: 366-73 (2011) Article DOI: 10.1021/jm101230g BindingDB Entry DOI: 10.7270/Q2ZC83T4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Translocator protein (Rattus norvegicus (rat)) | BDBM50104776 (CHEMBL3597377) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.310 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Pisa Curated by ChEMBL | Assay Description Inhibition of [3H]PK11195 binding to TSPO in rat kidney mitochondrial membranes | J Med Chem 58: 6081-92 (2015) Article DOI: 10.1021/acs.jmedchem.5b00689 BindingDB Entry DOI: 10.7270/Q20003WH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Translocator protein (Rattus norvegicus (rat)) | BDBM50253894 (CHEMBL517895 | N-butyl-2-(5-chloro-2-(4-chlorophen...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.360 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Pisa Curated by ChEMBL | Assay Description Displacement of [3H]PK11195 from translocator protein in rat kidney mitochondrial membrane | J Med Chem 51: 5798-806 (2008) Article DOI: 10.1021/jm8003224 BindingDB Entry DOI: 10.7270/Q2GF0VD5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Translocator protein (Rattus norvegicus (rat)) | BDBM50104772 (CHEMBL3597381) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.370 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Pisa Curated by ChEMBL | Assay Description Inhibition of [3H]PK11195 binding to TSPO in rat kidney mitochondrial membranes | J Med Chem 58: 6081-92 (2015) Article DOI: 10.1021/acs.jmedchem.5b00689 BindingDB Entry DOI: 10.7270/Q20003WH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Translocator protein (Rattus norvegicus (rat)) | BDBM22038 (2-[2-(4-fluorophenyl)-1H-indol-3-yl]-N,N-dihexyl-2...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.370 | -50.0 | n/a | n/a | n/a | n/a | n/a | 7.4 | 4 |
Universita di Pisa | Assay Description Assays were performed by incubating aliquots of rat kidney mitochondria suspensions with [3H]PK 11195 and a range of concentrations of the test compo... | J Med Chem 50: 404-7 (2007) Article DOI: 10.1021/jm061137o BindingDB Entry DOI: 10.7270/Q23J3B8X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Translocator protein (Rattus norvegicus (rat)) | BDBM22038 (2-[2-(4-fluorophenyl)-1H-indol-3-yl]-N,N-dihexyl-2...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.370 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Pisa Curated by ChEMBL | Assay Description Binding affinity to peripheral benzodiazepine receptors using [3H]-PK11195 radioligand in rat kidney mitochondrial membrane | J Med Chem 47: 1852-5 (2004) Article DOI: 10.1021/jm030973k BindingDB Entry DOI: 10.7270/Q2WQ04K6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Translocator protein (Rattus norvegicus (rat)) | BDBM22038 (2-[2-(4-fluorophenyl)-1H-indol-3-yl]-N,N-dihexyl-2...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.370 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Mental Health Curated by ChEMBL | Assay Description Displacement of [11C]PBR28 from TSPO in rat kidney mitochondrial membrane | J Med Chem 54: 366-73 (2011) Article DOI: 10.1021/jm101230g BindingDB Entry DOI: 10.7270/Q2ZC83T4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Translocator protein (Rattus norvegicus (rat)) | BDBM50253595 (2-(5-fluoro-2-phenyl-1H-indol-3-yl)-N,N-dihexyl-2-...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.370 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Pisa Curated by ChEMBL | Assay Description Displacement of [3H]PK11195 from translocator protein in rat kidney mitochondrial membrane | J Med Chem 51: 5798-806 (2008) Article DOI: 10.1021/jm8003224 BindingDB Entry DOI: 10.7270/Q2GF0VD5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Translocator protein (Rattus norvegicus (rat)) | BDBM50011498 (CHEMBL3261908) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.442 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Salerno Curated by ChEMBL | Assay Description Displacement of [3H]PK11195 from TSPO in rat kidney mitochondrial membranes | J Med Chem 57: 2413-28 (2014) Article DOI: 10.1021/jm401721h BindingDB Entry DOI: 10.7270/Q2416ZKP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine deaminase (Bos taurus (bovine)) | BDBM50171395 (2-Undecyl-2H-pyrazolo[3,4-d]pyrimidin-4-ylamine | ...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.470 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Pisa Curated by ChEMBL | Assay Description Inhibitory constant against bovine spleen Adenosine deaminase | J Med Chem 48: 5162-74 (2005) Article DOI: 10.1021/jm050136d BindingDB Entry DOI: 10.7270/Q2542PCH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Translocator protein (Rattus norvegicus (rat)) | BDBM50011495 (CHEMBL3261905) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.489 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Salerno Curated by ChEMBL | Assay Description Displacement of [3H]PK11195 from TSPO in rat kidney mitochondrial membranes | J Med Chem 57: 2413-28 (2014) Article DOI: 10.1021/jm401721h BindingDB Entry DOI: 10.7270/Q2416ZKP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A1 (Homo sapiens (Human)) | BDBM21173 (1,3-dipropyl-8-cyclopentylxanthine | 8-cyclopentyl...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Pisa Curated by ChEMBL | Assay Description Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in CHO cell membrane after 180 mins | Eur J Med Chem 69: 331-7 (2013) Article DOI: 10.1016/j.ejmech.2013.09.001 BindingDB Entry DOI: 10.7270/Q28918TN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Translocator protein (Rattus norvegicus (rat)) | BDBM50588817 (CHEMBL5193551) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Citation and Details Article DOI: 10.1016/j.ejmech.2020.112924 BindingDB Entry DOI: 10.7270/Q25D8WSD | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Translocator protein (Rattus norvegicus (rat)) | BDBM22041 (2-[6-chloro-2-(4-chlorophenyl)imidazo[1,2-a]pyridi...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Salerno Curated by ChEMBL | Assay Description Displacement of [3H]PK11195 from TSPO in rat kidney mitochondrial membranes by competitive binding assay | J Med Chem 55: 4506-10 (2012) Article DOI: 10.1021/jm201703k BindingDB Entry DOI: 10.7270/Q2TB1806 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A1 (Homo sapiens (Human)) | BDBM21173 (1,3-dipropyl-8-cyclopentylxanthine | 8-cyclopentyl...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Pisa Curated by ChEMBL | Assay Description Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in CHO cells | J Med Chem 50: 5676-84 (2007) Article DOI: 10.1021/jm0708376 BindingDB Entry DOI: 10.7270/Q2SJ1MFX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A1 (Homo sapiens (Human)) | BDBM21216 (2-[4-(ethylsulfanyl)-1H-1,3-benzodiazol-2-yl]quino...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.5 | -53.1 | n/a | n/a | n/a | n/a | n/a | 7.4 | 25 |
Universita di Napoli | Assay Description The membranes prepared from CHO cells transfected with human adenosine A1 receptors were used in binding assays. Nonspecific binding was determined i... | J Med Chem 51: 1764-70 (2008) Article DOI: 10.1021/jm701159t BindingDB Entry DOI: 10.7270/Q2MP51JK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Translocator protein (Rattus norvegicus (rat)) | BDBM22041 (2-[6-chloro-2-(4-chlorophenyl)imidazo[1,2-a]pyridi...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Pisa Curated by ChEMBL | Assay Description Displacement of [3H]PK11195 from translocator protein in rat kidney mitochondrial membrane | J Med Chem 51: 5798-806 (2008) Article DOI: 10.1021/jm8003224 BindingDB Entry DOI: 10.7270/Q2GF0VD5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A1 (Homo sapiens (Human)) | BDBM21216 (2-[4-(ethylsulfanyl)-1H-1,3-benzodiazol-2-yl]quino...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Napoli"Federico II" Curated by ChEMBL | Assay Description Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in CHO cells | J Med Chem 48: 8253-60 (2005) Article DOI: 10.1021/jm050792d BindingDB Entry DOI: 10.7270/Q2RF5VTX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A1 (Homo sapiens (Human)) | BDBM21173 (1,3-dipropyl-8-cyclopentylxanthine | 8-cyclopentyl...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Napoli"Federico II" Curated by ChEMBL | Assay Description Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in CHO cells | J Med Chem 48: 8253-60 (2005) Article DOI: 10.1021/jm050792d BindingDB Entry DOI: 10.7270/Q2RF5VTX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Translocator protein (Rattus norvegicus (rat)) | BDBM50060095 (2-[6,8-Dichloro-2-(4-chloro-phenyl)-imidazo[1,2-a]...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Mental Health Curated by ChEMBL | Assay Description Displacement of [11C]PK11195 from TSPO in rat kidney mitochondrial membrane | J Med Chem 54: 366-73 (2011) Article DOI: 10.1021/jm101230g BindingDB Entry DOI: 10.7270/Q2ZC83T4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A1 (BOVINE) | BDBM21173 (1,3-dipropyl-8-cyclopentylxanthine | 8-cyclopentyl...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars | PubMed | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Pisa Curated by ChEMBL | Assay Description Displacement of [3H]CHA from adenosine A1 receptors was determined in bovine cortical membranes | J Med Chem 44: 316-27 (2001) BindingDB Entry DOI: 10.7270/Q2D79C4H | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A1 (Homo sapiens (Human)) | BDBM21173 (1,3-dipropyl-8-cyclopentylxanthine | 8-cyclopentyl...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | 0.5 | -53.1 | n/a | n/a | n/a | n/a | n/a | 7.4 | 25 |
Università di Napoli Federico II | Assay Description Aliquots of cell membranes (30 ug proteins) were incubated at 25 °C for 180 min in 500 uL of binding buffer (50 mM Tris-HCl, 2 mM MgCl2, 2 units/... | Chem Biol Drug Des 88: 724-729 (2016) Article DOI: 10.1111/cbdd.12801 BindingDB Entry DOI: 10.7270/Q25M64JG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A1 (Homo sapiens (Human)) | BDBM21173 (1,3-dipropyl-8-cyclopentylxanthine | 8-cyclopentyl...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Pisa Curated by ChEMBL | Assay Description Displacement of [3H]DPCPX from human A1 adenosine receptor expressed in CHO cell membrane | J Med Chem 55: 1490-9 (2012) Article DOI: 10.1021/jm201177b BindingDB Entry DOI: 10.7270/Q2CR5VCS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Translocator protein (Homo sapiens (Human)) | BDBM22041 (2-[6-chloro-2-(4-chlorophenyl)imidazo[1,2-a]pyridi...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Citation and Details Article DOI: 10.1016/j.ejmech.2020.112924 BindingDB Entry DOI: 10.7270/Q25D8WSD | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A1 (Homo sapiens (Human)) | BDBM21173 (1,3-dipropyl-8-cyclopentylxanthine | 8-cyclopentyl...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | 0.5 | -53.1 | n/a | n/a | n/a | n/a | n/a | 7.4 | 25 |
Universita di Napoli | Assay Description The membranes prepared from CHO cells transfected with human adenosine A1 receptors were used in binding assays. Nonspecific binding was determined i... | J Med Chem 51: 1764-70 (2008) Article DOI: 10.1021/jm701159t BindingDB Entry DOI: 10.7270/Q2MP51JK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Translocator protein (Rattus norvegicus (rat)) | BDBM22041 (2-[6-chloro-2-(4-chlorophenyl)imidazo[1,2-a]pyridi...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 0.5 | -49.3 | n/a | n/a | n/a | n/a | n/a | 7.4 | 4 |
Universita di Pisa | Assay Description Assays were performed by incubating aliquots of rat kidney mitochondria suspensions with [3H]PK 11195 and a range of concentrations of the test compo... | J Med Chem 50: 404-7 (2007) Article DOI: 10.1021/jm061137o BindingDB Entry DOI: 10.7270/Q23J3B8X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Translocator protein (Rattus norvegicus (rat)) | BDBM50104771 (CHEMBL3597382) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.510 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Pisa Curated by ChEMBL | Assay Description Inhibition of [3H]PK11195 binding to TSPO in rat kidney mitochondrial membranes | J Med Chem 58: 6081-92 (2015) Article DOI: 10.1021/acs.jmedchem.5b00689 BindingDB Entry DOI: 10.7270/Q20003WH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Translocator protein (Rattus norvegicus (rat)) | BDBM50104770 (CHEMBL3597383) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.510 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Pisa Curated by ChEMBL | Assay Description Inhibition of [3H]PK11195 binding to TSPO in rat kidney mitochondrial membranes | J Med Chem 58: 6081-92 (2015) Article DOI: 10.1021/acs.jmedchem.5b00689 BindingDB Entry DOI: 10.7270/Q20003WH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Translocator protein (Rattus norvegicus (rat)) | BDBM50104774 (CHEMBL3597379) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.520 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Pisa Curated by ChEMBL | Assay Description Inhibition of [3H]PK11195 binding to TSPO in rat kidney mitochondrial membranes | J Med Chem 58: 6081-92 (2015) Article DOI: 10.1021/acs.jmedchem.5b00689 BindingDB Entry DOI: 10.7270/Q20003WH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Translocator protein (Rattus norvegicus (rat)) | BDBM50104779 (CHEMBL3597374) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.530 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Pisa Curated by ChEMBL | Assay Description Inhibition of [3H]PK11195 binding to TSPO in rat kidney mitochondrial membranes | J Med Chem 58: 6081-92 (2015) Article DOI: 10.1021/acs.jmedchem.5b00689 BindingDB Entry DOI: 10.7270/Q20003WH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Translocator protein (Rattus norvegicus (rat)) | BDBM50104775 (CHEMBL3597378) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.540 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Pisa Curated by ChEMBL | Assay Description Inhibition of [3H]PK11195 binding to TSPO in rat kidney mitochondrial membranes | J Med Chem 58: 6081-92 (2015) Article DOI: 10.1021/acs.jmedchem.5b00689 BindingDB Entry DOI: 10.7270/Q20003WH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Translocator protein (Rattus norvegicus (rat)) | BDBM50143231 (2-[2-(4-Chloro-phenyl)-1H-indol-3-yl]-N,N-dihexyl-...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.550 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Pisa Curated by ChEMBL | Assay Description Binding affinity to peripheral benzodiazepine receptors using [3H]-PK11195 radioligand in rat kidney mitochondrial membrane | J Med Chem 47: 1852-5 (2004) Article DOI: 10.1021/jm030973k BindingDB Entry DOI: 10.7270/Q2WQ04K6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Carbonic anhydrase 9 (Homo sapiens (Human)) | BDBM50341403 (CHEMBL4173265) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 0.550 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Pisa Curated by ChEMBL | Assay Description Inhibition of recombinant human CA9 preincubated for 15 mins by phenol red dye-based stopped-flow CO2 hydration assay | J Med Chem 61: 5765-5770 (2018) Article DOI: 10.1021/acs.jmedchem.8b00670 BindingDB Entry DOI: 10.7270/Q2DB84F9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Translocator protein (Rattus norvegicus (rat)) | BDBM50253715 (CHEMBL518662 | N-benzyl-N-ethyl-2-(2-(4-nitropheny...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.550 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Pisa Curated by ChEMBL | Assay Description Displacement of [3H]PK11195 from translocator protein in rat kidney mitochondrial membrane | J Med Chem 51: 5798-806 (2008) Article DOI: 10.1021/jm8003224 BindingDB Entry DOI: 10.7270/Q2GF0VD5 | |||||||||||
More data for this Ligand-Target Pair |
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