Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Tyrosine-protein kinase BTK [C481S] (Homo sapiens (Human)) | BDBM499813 ((2-chloro-4-phenoxyphenyl)(4- (((3R,6R)-6-(hydroxy...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.370 | n/a | n/a | n/a | n/a | n/a | n/a |
ArQule, Inc. US Patent | Assay Description Enzyme assay using full length recombinant active form of wild-type BTK and BTK-C481S was measured as described previously (Anastassiadis T, et al., ... | US Patent US11020398 (2021) BindingDB Entry DOI: 10.7270/Q2DZ0CFC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase BTK [C481S] (Homo sapiens (Human)) | BDBM499811 (US11020398, Compound I-123 | US20230364079, Exampl...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem | PDB US Patent | n/a | n/a | 0.390 | n/a | n/a | n/a | n/a | n/a | n/a |
ArQule, Inc. US Patent | Assay Description Enzyme assay using full length recombinant active form of wild-type BTK and BTK-C481S was measured as described previously (Anastassiadis T, et al., ... | US Patent US11020398 (2021) BindingDB Entry DOI: 10.7270/Q2DZ0CFC | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Tyrosine-protein kinase BTK (Homo sapiens (Human)) | BDBM499813 ((2-chloro-4-phenoxyphenyl)(4- (((3R,6R)-6-(hydroxy...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.560 | n/a | n/a | n/a | n/a | n/a | n/a |
ArQule, Inc. US Patent | Assay Description Enzyme assay using full length recombinant active form of wild-type BTK and BTK-C481S was measured as described previously (Anastassiadis T, et al., ... | US Patent US11020398 (2021) BindingDB Entry DOI: 10.7270/Q2DZ0CFC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase BTK (Homo sapiens (Human)) | BDBM499813 ((2-chloro-4-phenoxyphenyl)(4- (((3R,6R)-6-(hydroxy...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.560 | n/a | n/a | n/a | n/a | n/a | n/a |
ArQule, Inc. US Patent | Assay Description Enzyme assay using full length recombinant active form of wild-type BTK and BTK-C481S was measured as described previously (Anastassiadis T, et al., ... | US Patent US11020398 (2021) BindingDB Entry DOI: 10.7270/Q2DZ0CFC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase BTK (Homo sapiens (Human)) | BDBM499810 (N-((S)-1-((2S,5R)-5-((5-(2-chloro-4- phenoxybenzoy...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.770 | n/a | n/a | n/a | n/a | n/a | n/a |
ArQule, Inc. US Patent | Assay Description Full length unphosphorylated form of BTK expressed in Sf9 cells was employed to test inhibitory activity in the inactive BTK assay. The assay was mea... | US Patent US11020398 (2021) BindingDB Entry DOI: 10.7270/Q2DZ0CFC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase BTK [C481S] (Homo sapiens (Human)) | BDBM499814 ((2-chloro-4-phenoxyphenyl)(4- (((3S,6S)-6-(hydroxy...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.790 | n/a | n/a | n/a | n/a | n/a | n/a |
ArQule, Inc. US Patent | Assay Description Enzyme assay using full length recombinant active form of wild-type BTK and BTK-C481S was measured as described previously (Anastassiadis T, et al., ... | US Patent US11020398 (2021) BindingDB Entry DOI: 10.7270/Q2DZ0CFC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase BTK (Homo sapiens (Human)) | BDBM499811 (US11020398, Compound I-123 | US20230364079, Exampl...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem | PDB US Patent | n/a | n/a | 0.850 | n/a | n/a | n/a | n/a | n/a | n/a |
ArQule, Inc. US Patent | Assay Description Enzyme assay using full length recombinant active form of wild-type BTK and BTK-C481S was measured as described previously (Anastassiadis T, et al., ... | US Patent US11020398 (2021) BindingDB Entry DOI: 10.7270/Q2DZ0CFC | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Tyrosine-protein kinase BTK (Homo sapiens (Human)) | BDBM499811 (US11020398, Compound I-123 | US20230364079, Exampl...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem | PDB US Patent | n/a | n/a | 0.850 | n/a | n/a | n/a | n/a | n/a | n/a |
ArQule, Inc. US Patent | Assay Description Enzyme assay using full length recombinant active form of wild-type BTK and BTK-C481S was measured as described previously (Anastassiadis T, et al., ... | US Patent US11020398 (2021) BindingDB Entry DOI: 10.7270/Q2DZ0CFC | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Tyrosine-protein kinase BTK (Homo sapiens (Human)) | BDBM499838 ((2-chloro-4-phenoxyphenyl)(4- (((3R,6S)-6-((R)-1- ...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.930 | n/a | n/a | n/a | n/a | n/a | n/a |
ArQule, Inc. US Patent | Assay Description Full length unphosphorylated form of BTK expressed in Sf9 cells was employed to test inhibitory activity in the inactive BTK assay. The assay was mea... | US Patent US11020398 (2021) BindingDB Entry DOI: 10.7270/Q2DZ0CFC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase BTK (Homo sapiens (Human)) | BDBM499976 ((racemic)-1-(2-(((5-(2-chloro-4- phenoxybenzoyl)-7...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.980 | n/a | n/a | n/a | n/a | n/a | n/a |
ArQule, Inc. US Patent | Assay Description Purified full-length inactive BTK (wild type and C481 mutant, N-terminal 6XHIS tagged BTK, Mwt=78.2 kDa) were activated using soluble inositol hexaki... | US Patent US11020398 (2021) BindingDB Entry DOI: 10.7270/Q2DZ0CFC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase BTK (Homo sapiens (Human)) | BDBM499869 (N-(cis-4-((5-(2-chloro-4- phenoxybenzoyl)-7H-pyrro...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.980 | n/a | n/a | n/a | n/a | n/a | n/a |
ArQule, Inc. US Patent | Assay Description The active BTK assay consisted of phosphorylated form of full length BTK. The assay was performed in a buffer solution utilized in the inactive BTK a... | US Patent US11020398 (2021) BindingDB Entry DOI: 10.7270/Q2DZ0CFC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase BTK (Homo sapiens (Human)) | BDBM499924 (N-(4-chloro-3-(4-(((3R,6S)-6- (hydroxymethyl)tetra...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.980 | n/a | n/a | n/a | n/a | n/a | n/a |
ArQule, Inc. US Patent | Assay Description Purified full-length inactive BTK (wild type and C481 mutant, N-terminal 6XHIS tagged BTK, Mwt=78.2 kDa) were activated using soluble inositol hexaki... | US Patent US11020398 (2021) BindingDB Entry DOI: 10.7270/Q2DZ0CFC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase BTK (Homo sapiens (Human)) | BDBM499974 ((racemic)-1-(2-(((5-(2-chloro-4- phenoxybenzoyl)-7...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.980 | n/a | n/a | n/a | n/a | n/a | n/a |
ArQule, Inc. US Patent | Assay Description Purified full-length inactive BTK (wild type and C481 mutant, N-terminal 6XHIS tagged BTK, Mwt=78.2 kDa) were activated using soluble inositol hexaki... | US Patent US11020398 (2021) BindingDB Entry DOI: 10.7270/Q2DZ0CFC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase BTK (Homo sapiens (Human)) | BDBM499890 ((S)-2-hydroxy-N-(cis-4-((5-(4- phenoxybenzoyl)-7H-...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
ArQule, Inc. US Patent | Assay Description The active BTK assay consisted of phosphorylated form of full length BTK. The assay was performed in a buffer solution utilized in the inactive BTK a... | US Patent US11020398 (2021) BindingDB Entry DOI: 10.7270/Q2DZ0CFC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase BTK (Homo sapiens (Human)) | BDBM499991 (US11020398, Compound I-360e | racemic-cis-(2-chlor...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.07 | n/a | n/a | n/a | n/a | n/a | n/a |
ArQule, Inc. US Patent | Assay Description Purified full-length inactive BTK (wild type and C481 mutant, N-terminal 6XHIS tagged BTK, Mwt=78.2 kDa) were activated using soluble inositol hexaki... | US Patent US11020398 (2021) BindingDB Entry DOI: 10.7270/Q2DZ0CFC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase BTK (Homo sapiens (Human)) | BDBM499854 ((4-(((3R,6S)-6-((S)-1- aminoethyl)tetrahydro-2H-py...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a |
ArQule, Inc. US Patent | Assay Description Full length unphosphorylated form of BTK expressed in Sf9 cells was employed to test inhibitory activity in the inactive BTK assay. The assay was mea... | US Patent US11020398 (2021) BindingDB Entry DOI: 10.7270/Q2DZ0CFC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase BTK (Homo sapiens (Human)) | BDBM499892 (N-((S)-1-((2S,5R)-5-((5-(2-methyl-4- phenoxybenzoy...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a |
ArQule, Inc. US Patent | Assay Description The active BTK assay consisted of phosphorylated form of full length BTK. The assay was performed in a buffer solution utilized in the inactive BTK a... | US Patent US11020398 (2021) BindingDB Entry DOI: 10.7270/Q2DZ0CFC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase BTK (Homo sapiens (Human)) | BDBM499881 ((S)-N-(cis-4-((5-(2-chloro-4- phenoxybenzoyl)-7H-p...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.20 | n/a | n/a | n/a | n/a | n/a | n/a |
ArQule, Inc. US Patent | Assay Description The active BTK assay consisted of phosphorylated form of full length BTK. The assay was performed in a buffer solution utilized in the inactive BTK a... | US Patent US11020398 (2021) BindingDB Entry DOI: 10.7270/Q2DZ0CFC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase BTK (Homo sapiens (Human)) | BDBM499839 (N-(cis-4-((5-(2-chloro-4- phenoxybenzoyl)-7H-pyrro...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.30 | n/a | n/a | n/a | n/a | n/a | n/a |
ArQule, Inc. US Patent | Assay Description Full length unphosphorylated form of BTK expressed in Sf9 cells was employed to test inhibitory activity in the inactive BTK assay. The assay was mea... | US Patent US11020398 (2021) BindingDB Entry DOI: 10.7270/Q2DZ0CFC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase BTK (Homo sapiens (Human)) | BDBM499855 ((2-chloro-4-phenoxyphenyl)(4- (((3R,6S)-6-((S)-1- ...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.40 | n/a | n/a | n/a | n/a | n/a | n/a |
ArQule, Inc. US Patent | Assay Description Full length unphosphorylated form of BTK expressed in Sf9 cells was employed to test inhibitory activity in the inactive BTK assay. The assay was mea... | US Patent US11020398 (2021) BindingDB Entry DOI: 10.7270/Q2DZ0CFC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase BTK (Homo sapiens (Human)) | BDBM499891 (2-hydroxy-2-methyl-N-(cis-4-((5-(4- phenoxybenzoyl...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.40 | n/a | n/a | n/a | n/a | n/a | n/a |
ArQule, Inc. US Patent | Assay Description The active BTK assay consisted of phosphorylated form of full length BTK. The assay was performed in a buffer solution utilized in the inactive BTK a... | US Patent US11020398 (2021) BindingDB Entry DOI: 10.7270/Q2DZ0CFC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase BTK (Homo sapiens (Human)) | BDBM499888 ((2-chloro-4-phenoxyphenyl)(4-((cis-4- hydroxy-4-me...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.40 | n/a | n/a | n/a | n/a | n/a | n/a |
ArQule, Inc. US Patent | Assay Description The active BTK assay consisted of phosphorylated form of full length BTK. The assay was performed in a buffer solution utilized in the inactive BTK a... | US Patent US11020398 (2021) BindingDB Entry DOI: 10.7270/Q2DZ0CFC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human)) | BDBM108434 (US8609688, 12) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 1.44 | n/a | n/a | n/a | n/a | n/a | n/a |
ArQule, Inc. US Patent | Assay Description AKT1 activity was assayed using the GSK3-derived biotinylated peptide substrate, crosstide (biotin-GRPRTSSFAEG), and AlphaScreen (Amplified Luminesce... | US Patent US8962619 (2015) BindingDB Entry DOI: 10.7270/Q2W957W7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human)) | BDBM108434 (US8609688, 12) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 1.44 | n/a | n/a | n/a | n/a | 8.0 | 25 |
ArQule, Inc. US Patent | Assay Description AKT1 activity was assayed using the GSK3-derived biotinylated peptide substrate, crosstide (biotin-GRPRTSSFAEG), and AlphaScreen (Amplified Lum... | US Patent US8609688 (2013) BindingDB Entry DOI: 10.7270/Q2H41Q2M | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase BTK (Homo sapiens (Human)) | BDBM499889 ((2-chloro-4-phenoxyphenyl)(4-((trans- 4-hydroxy-4-...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.5 | n/a | n/a | n/a | n/a | n/a | n/a |
ArQule, Inc. US Patent | Assay Description The active BTK assay consisted of phosphorylated form of full length BTK. The assay was performed in a buffer solution utilized in the inactive BTK a... | US Patent US11020398 (2021) BindingDB Entry DOI: 10.7270/Q2DZ0CFC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human)) | BDBM108430 (US8609688, 8) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 1.5 | n/a | n/a | n/a | n/a | 8.0 | 25 |
ArQule, Inc. US Patent | Assay Description AKT1 activity was assayed using the GSK3-derived biotinylated peptide substrate, crosstide (biotin-GRPRTSSFAEG), and AlphaScreen (Amplified Lum... | US Patent US8609688 (2013) BindingDB Entry DOI: 10.7270/Q2H41Q2M | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human)) | BDBM108430 (US8609688, 8) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 1.5 | n/a | n/a | n/a | n/a | n/a | n/a |
ArQule, Inc. US Patent | Assay Description AKT1 activity was assayed using the GSK3-derived biotinylated peptide substrate, crosstide (biotin-GRPRTSSFAEG), and AlphaScreen (Amplified Luminesce... | US Patent US8962619 (2015) BindingDB Entry DOI: 10.7270/Q2W957W7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase BTK (Homo sapiens (Human)) | BDBM499882 (N-(cis-4-((5-(2-chloro-4- phenoxybenzoyl)-7H-pyrro...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.5 | n/a | n/a | n/a | n/a | n/a | n/a |
ArQule, Inc. US Patent | Assay Description The active BTK assay consisted of phosphorylated form of full length BTK. The assay was performed in a buffer solution utilized in the inactive BTK a... | US Patent US11020398 (2021) BindingDB Entry DOI: 10.7270/Q2DZ0CFC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase BTK (Homo sapiens (Human)) | BDBM499870 ((2-chloro-4-(3- fluorophenoxy)phenyl)(4-(((3R,6S)-...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.5 | n/a | n/a | n/a | n/a | n/a | n/a |
ArQule, Inc. US Patent | Assay Description The active BTK assay consisted of phosphorylated form of full length BTK. The assay was performed in a buffer solution utilized in the inactive BTK a... | US Patent US11020398 (2021) BindingDB Entry DOI: 10.7270/Q2DZ0CFC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase BTK (Homo sapiens (Human)) | BDBM499885 ((4-(((3R,6S)-6-((R)-1- hydroxyethyl)tetrahydro-2H-...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.60 | n/a | n/a | n/a | n/a | n/a | n/a |
ArQule, Inc. US Patent | Assay Description The active BTK assay consisted of phosphorylated form of full length BTK. The assay was performed in a buffer solution utilized in the inactive BTK a... | US Patent US11020398 (2021) BindingDB Entry DOI: 10.7270/Q2DZ0CFC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase BTK (Homo sapiens (Human)) | BDBM499893 (N-(((2S,5R)-5-((5-(4-phenoxybenzoyl)- 7H-pyrrolo[2...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.60 | n/a | n/a | n/a | n/a | n/a | n/a |
ArQule, Inc. US Patent | Assay Description The active BTK assay consisted of phosphorylated form of full length BTK. The assay was performed in a buffer solution utilized in the inactive BTK a... | US Patent US11020398 (2021) BindingDB Entry DOI: 10.7270/Q2DZ0CFC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human)) | BDBM108428 (US8609688, 6) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 1.63 | n/a | n/a | n/a | n/a | n/a | n/a |
ArQule, Inc. US Patent | Assay Description AKT1 activity was assayed using the GSK3-derived biotinylated peptide substrate, crosstide (biotin-GRPRTSSFAEG), and AlphaScreen (Amplified Luminesce... | US Patent US8962619 (2015) BindingDB Entry DOI: 10.7270/Q2W957W7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human)) | BDBM108428 (US8609688, 6) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 1.63 | n/a | n/a | n/a | n/a | 8.0 | 25 |
ArQule, Inc. US Patent | Assay Description AKT1 activity was assayed using the GSK3-derived biotinylated peptide substrate, crosstide (biotin-GRPRTSSFAEG), and AlphaScreen (Amplified Lum... | US Patent US8609688 (2013) BindingDB Entry DOI: 10.7270/Q2H41Q2M | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase BTK (Homo sapiens (Human)) | BDBM499815 (N-(((2S,5R)-5-((5-(2-chloro-4- phenoxybenzoyl)-7H-...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.63 | n/a | n/a | n/a | n/a | n/a | n/a |
ArQule, Inc. US Patent | Assay Description The active BTK assay consisted of phosphorylated form of full length BTK. The assay was performed in a buffer solution utilized in the inactive BTK a... | US Patent US11020398 (2021) BindingDB Entry DOI: 10.7270/Q2DZ0CFC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human)) | BDBM130225 (US8815854, 14) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 1.69 | n/a | n/a | n/a | n/a | 8.0 | n/a |
ArQule, Inc. US Patent | Assay Description AKT1 activity was assayed using the GSK3-derived biotinylated peptide substrate, crosstide (biotin-GRPRTSSFAEG), and AlphaScreen (Amplified Luminesce... | US Patent US8815854 (2014) BindingDB Entry DOI: 10.7270/Q2J67FMR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase BTK (Homo sapiens (Human)) | BDBM499876 ((2-chloro-4-phenoxyphenyl)(4- (((3R,6S)-6-(2-hydro...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.70 | n/a | n/a | n/a | n/a | n/a | n/a |
ArQule, Inc. US Patent | Assay Description The active BTK assay consisted of phosphorylated form of full length BTK. The assay was performed in a buffer solution utilized in the inactive BTK a... | US Patent US11020398 (2021) BindingDB Entry DOI: 10.7270/Q2DZ0CFC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human)) | BDBM108426 (US8609688, 4) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 1.70 | n/a | n/a | n/a | n/a | 8.0 | 25 |
ArQule, Inc. US Patent | Assay Description AKT1 activity was assayed using the GSK3-derived biotinylated peptide substrate, crosstide (biotin-GRPRTSSFAEG), and AlphaScreen (Amplified Lum... | US Patent US8609688 (2013) BindingDB Entry DOI: 10.7270/Q2H41Q2M | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human)) | BDBM108426 (US8609688, 4) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 1.70 | n/a | n/a | n/a | n/a | n/a | n/a |
ArQule, Inc. US Patent | Assay Description AKT1 activity was assayed using the GSK3-derived biotinylated peptide substrate, crosstide (biotin-GRPRTSSFAEG), and AlphaScreen (Amplified Luminesce... | US Patent US8962619 (2015) BindingDB Entry DOI: 10.7270/Q2W957W7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase BTK (Homo sapiens (Human)) | BDBM499865 ((2-chloro-4-phenoxyphenyl)(4-((trans- 4-((dimethyl...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.70 | n/a | n/a | n/a | n/a | n/a | n/a |
ArQule, Inc. US Patent | Assay Description The active BTK assay consisted of phosphorylated form of full length BTK. The assay was performed in a buffer solution utilized in the inactive BTK a... | US Patent US11020398 (2021) BindingDB Entry DOI: 10.7270/Q2DZ0CFC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase BTK (Homo sapiens (Human)) | BDBM499857 ((2-chloro-4-phenoxyphenyl)(4-((trans- 4-hydroxycyc...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.70 | n/a | n/a | n/a | n/a | n/a | n/a |
ArQule, Inc. US Patent | Assay Description Full length unphosphorylated form of BTK expressed in Sf9 cells was employed to test inhibitory activity in the inactive BTK assay. The assay was mea... | US Patent US11020398 (2021) BindingDB Entry DOI: 10.7270/Q2DZ0CFC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human)) | BDBM108440 (US8609688, 18) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 1.79 | n/a | n/a | n/a | n/a | n/a | n/a |
ArQule, Inc. US Patent | Assay Description AKT1 activity was assayed using the GSK3-derived biotinylated peptide substrate, crosstide (biotin-GRPRTSSFAEG), and AlphaScreen (Amplified Luminesce... | US Patent US8962619 (2015) BindingDB Entry DOI: 10.7270/Q2W957W7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human)) | BDBM108440 (US8609688, 18) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 1.79 | n/a | n/a | n/a | n/a | 8.0 | 25 |
ArQule, Inc. US Patent | Assay Description AKT1 activity was assayed using the GSK3-derived biotinylated peptide substrate, crosstide (biotin-GRPRTSSFAEG), and AlphaScreen (Amplified Lum... | US Patent US8609688 (2013) BindingDB Entry DOI: 10.7270/Q2H41Q2M | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase BTK (Homo sapiens (Human)) | BDBM499894 ((R)-2-hydroxy-N-(cis-4-((5-(4- phenoxybenzoyl)-7H-...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.80 | n/a | n/a | n/a | n/a | n/a | n/a |
ArQule, Inc. US Patent | Assay Description The active BTK assay consisted of phosphorylated form of full length BTK. The assay was performed in a buffer solution utilized in the inactive BTK a... | US Patent US11020398 (2021) BindingDB Entry DOI: 10.7270/Q2DZ0CFC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase BTK (Homo sapiens (Human)) | BDBM499868 (US11020398, Compound I-180 | rac-(2-chloro-4-pheno...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.80 | n/a | n/a | n/a | n/a | n/a | n/a |
ArQule, Inc. US Patent | Assay Description The active BTK assay consisted of phosphorylated form of full length BTK. The assay was performed in a buffer solution utilized in the inactive BTK a... | US Patent US11020398 (2021) BindingDB Entry DOI: 10.7270/Q2DZ0CFC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase BTK (Homo sapiens (Human)) | BDBM499867 (US11020398, Compound I-179 | rac-(2-chloro-4-pheno...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.80 | n/a | n/a | n/a | n/a | n/a | n/a |
ArQule, Inc. US Patent | Assay Description The active BTK assay consisted of phosphorylated form of full length BTK. The assay was performed in a buffer solution utilized in the inactive BTK a... | US Patent US11020398 (2021) BindingDB Entry DOI: 10.7270/Q2DZ0CFC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human)) | BDBM108436 (US8609688, 14) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 1.84 | n/a | n/a | n/a | n/a | 8.0 | 25 |
ArQule, Inc. US Patent | Assay Description AKT1 activity was assayed using the GSK3-derived biotinylated peptide substrate, crosstide (biotin-GRPRTSSFAEG), and AlphaScreen (Amplified Lum... | US Patent US8609688 (2013) BindingDB Entry DOI: 10.7270/Q2H41Q2M | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human)) | BDBM108436 (US8609688, 14) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 1.84 | n/a | n/a | n/a | n/a | n/a | n/a |
ArQule, Inc. US Patent | Assay Description AKT1 activity was assayed using the GSK3-derived biotinylated peptide substrate, crosstide (biotin-GRPRTSSFAEG), and AlphaScreen (Amplified Luminesce... | US Patent US8962619 (2015) BindingDB Entry DOI: 10.7270/Q2W957W7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase BTK (Homo sapiens (Human)) | BDBM499904 ((R)-N-(((2S,5R)-5-((5-(2-chloro-4- phenoxybenzoyl)...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.90 | n/a | n/a | n/a | n/a | n/a | n/a |
ArQule, Inc. US Patent | Assay Description The active BTK assay consisted of phosphorylated form of full length BTK. The assay was performed in a buffer solution utilized in the inactive BTK a... | US Patent US11020398 (2021) BindingDB Entry DOI: 10.7270/Q2DZ0CFC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase BTK (Homo sapiens (Human)) | BDBM499898 ((S)-N-(((2S,5R)-5-((5-(2-chloro-4- phenoxybenzoyl)...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.90 | n/a | n/a | n/a | n/a | n/a | n/a |
ArQule, Inc. US Patent | Assay Description The active BTK assay consisted of phosphorylated form of full length BTK. The assay was performed in a buffer solution utilized in the inactive BTK a... | US Patent US11020398 (2021) BindingDB Entry DOI: 10.7270/Q2DZ0CFC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase BTK (Homo sapiens (Human)) | BDBM499739 (1-(cis-4-((5-(2-chlorobenzoyl)-7H- pyrrolo[2,3-d]p...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.90 | n/a | n/a | n/a | n/a | n/a | n/a |
ArQule, Inc. US Patent | Assay Description Full length unphosphorylated form of BTK expressed in Sf9 cells was employed to test inhibitory activity in the inactive BTK assay. The assay was mea... | US Patent US11020398 (2021) BindingDB Entry DOI: 10.7270/Q2DZ0CFC | |||||||||||
More data for this Ligand-Target Pair |
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