Found 457 hits with Last Name = 'taveras' and Initial = 'ag' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
C-X-C chemokine receptor type 2
(Homo sapiens (Human)) | BDBM50211457
(3-(2-((R)-1-(4-sec-butylfuran-2-yl)propylamino)-3,...)Show SMILES CCC(C)c1coc(c1)[C@@H](CC)Nc1c(Nc2cccc(C(=O)N(C)C)c2O)c(=O)c1=O |w:2.2| Show InChI InChI=1S/C24H29N3O5/c1-6-13(3)14-11-18(32-12-14)16(7-2)25-19-20(23(30)22(19)29)26-17-10-8-9-15(21(17)28)24(31)27(4)5/h8-13,16,25-26,28H,6-7H2,1-5H3/t13?,16-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 0.600 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Schering Plough Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]IL8 from human CXCR2 expressed in CHO cells by SPA |
Bioorg Med Chem Lett 17: 3778-83 (2007)
Article DOI: 10.1016/j.bmcl.2007.04.016
BindingDB Entry DOI: 10.7270/Q25D8RH5 |
More data for this
Ligand-Target Pair | |
C-X-C chemokine receptor type 2
(Homo sapiens (Human)) | BDBM50211449
((R)-3-(3,4-dioxo-2-(1-(4-(pentan-3-yl)furan-2-yl)p...)Show SMILES CCC(CC)c1coc(c1)[C@@H](CC)Nc1c(Nc2cccc(C(=O)N(C)C)c2O)c(=O)c1=O Show InChI InChI=1S/C25H31N3O5/c1-6-14(7-2)15-12-19(33-13-15)17(8-3)26-20-21(24(31)23(20)30)27-18-11-9-10-16(22(18)29)25(32)28(4)5/h9-14,17,26-27,29H,6-8H2,1-5H3/t17-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 0.800 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Schering Plough Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]IL8 from human CXCR2 expressed in CHO cells by SPA |
Bioorg Med Chem Lett 17: 3778-83 (2007)
Article DOI: 10.1016/j.bmcl.2007.04.016
BindingDB Entry DOI: 10.7270/Q25D8RH5 |
More data for this
Ligand-Target Pair | |
C-X-C chemokine receptor type 2
(Homo sapiens (Human)) | BDBM50236065
((R)-3-(2-(1-(3-fluoro-5-methylphenyl)-2-methylprop...)Show SMILES CC(C)[C@@H](Nc1c(Nc2cccc(C(=O)N(C)C)c2O)c(=O)c1=O)c1cc(C)cc(F)c1 Show InChI InChI=1S/C24H26FN3O4/c1-12(2)18(14-9-13(3)10-15(25)11-14)27-20-19(22(30)23(20)31)26-17-8-6-7-16(21(17)29)24(32)28(4)5/h6-12,18,26-27,29H,1-5H3/t18-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmacopeia, Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I]IL8 from human CXCR2 by SPA assay |
Bioorg Med Chem Lett 18: 1864-8 (2008)
Article DOI: 10.1016/j.bmcl.2008.02.010
BindingDB Entry DOI: 10.7270/Q2CC10DK |
More data for this
Ligand-Target Pair | |
C-X-C chemokine receptor type 2
(Homo sapiens (Human)) | BDBM50211458
((R)-2-hydroxy-3-(2-(1-(4-isopropylfuran-2-yl)propy...)Show SMILES CC[C@@H](Nc1c(Nc2cccc(C(=O)N(C)C)c2O)c(=O)c1=O)c1cc(co1)C(C)C Show InChI InChI=1S/C23H27N3O5/c1-6-15(17-10-13(11-31-17)12(2)3)24-18-19(22(29)21(18)28)25-16-9-7-8-14(20(16)27)23(30)26(4)5/h7-12,15,24-25,27H,6H2,1-5H3/t15-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Schering Plough Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]IL8 from human CXCR2 expressed in CHO cells by SPA |
Bioorg Med Chem Lett 17: 3778-83 (2007)
Article DOI: 10.1016/j.bmcl.2007.04.016
BindingDB Entry DOI: 10.7270/Q25D8RH5 |
More data for this
Ligand-Target Pair | |
C-X-C chemokine receptor type 2
(Homo sapiens (Human)) | BDBM50211454
((R)-3-(2-(1-(4-ethylfuran-2-yl)propylamino)-3,4-di...)Show SMILES CC[C@@H](Nc1c(Nc2cccc(C(=O)N(C)C)c2O)c(=O)c1=O)c1cc(CC)co1 Show InChI InChI=1S/C22H25N3O5/c1-5-12-10-16(30-11-12)14(6-2)23-17-18(21(28)20(17)27)24-15-9-7-8-13(19(15)26)22(29)25(3)4/h7-11,14,23-24,26H,5-6H2,1-4H3/t14-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Schering Plough Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]IL8 from human CXCR2 expressed in CHO cells by SPA |
Bioorg Med Chem Lett 17: 3778-83 (2007)
Article DOI: 10.1016/j.bmcl.2007.04.016
BindingDB Entry DOI: 10.7270/Q25D8RH5 |
More data for this
Ligand-Target Pair | |
C-X-C chemokine receptor type 2
(Homo sapiens (Human)) | BDBM50236057
((R)-3-(2-(1-(3-fluoro-4-methoxyphenyl)-2-methylpro...)Show SMILES COc1ccc(cc1F)[C@H](Nc1c(Nc2cccc(C(=O)N(C)C)c2O)c(=O)c1=O)C(C)C Show InChI InChI=1S/C24H26FN3O5/c1-12(2)18(13-9-10-17(33-5)15(25)11-13)27-20-19(22(30)23(20)31)26-16-8-6-7-14(21(16)29)24(32)28(3)4/h6-12,18,26-27,29H,1-5H3/t18-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 1.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmacopeia, Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I]IL8 from human CXCR2 by SPA assay |
Bioorg Med Chem Lett 18: 1864-8 (2008)
Article DOI: 10.1016/j.bmcl.2008.02.010
BindingDB Entry DOI: 10.7270/Q2CC10DK |
More data for this
Ligand-Target Pair | |
C-X-C chemokine receptor type 2
(Homo sapiens (Human)) | BDBM50236066
((R)-3-(2-(1-(3,5-difluorophenyl)propylamino)-3,4-d...)Show SMILES CC[C@@H](Nc1c(Nc2cccc(C(=O)N(C)C)c2O)c(=O)c1=O)c1cc(F)cc(F)c1 Show InChI InChI=1S/C22H21F2N3O4/c1-4-15(11-8-12(23)10-13(24)9-11)25-17-18(21(30)20(17)29)26-16-7-5-6-14(19(16)28)22(31)27(2)3/h5-10,15,25-26,28H,4H2,1-3H3/t15-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 1.70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmacopeia, Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I]IL8 from human CXCR2 by SPA assay |
Bioorg Med Chem Lett 18: 1864-8 (2008)
Article DOI: 10.1016/j.bmcl.2008.02.010
BindingDB Entry DOI: 10.7270/Q2CC10DK |
More data for this
Ligand-Target Pair | |
C-X-C chemokine receptor type 2
(Homo sapiens (Human)) | BDBM50236050
((R)-3-(2-(1-(3-cyano-5-fluorophenyl)propylamino)-3...)Show SMILES CC[C@@H](Nc1c(Nc2cccc(C(=O)N(C)C)c2O)c(=O)c1=O)c1cc(F)cc(c1)C#N Show InChI InChI=1S/C23H21FN4O4/c1-4-16(13-8-12(11-25)9-14(24)10-13)26-18-19(22(31)21(18)30)27-17-7-5-6-15(20(17)29)23(32)28(2)3/h5-10,16,26-27,29H,4H2,1-3H3/t16-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 1.70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmacopeia, Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I]IL8 from human CXCR2 by SPA assay |
Bioorg Med Chem Lett 18: 1864-8 (2008)
Article DOI: 10.1016/j.bmcl.2008.02.010
BindingDB Entry DOI: 10.7270/Q2CC10DK |
More data for this
Ligand-Target Pair | |
C-X-C chemokine receptor type 2
(Homo sapiens (Human)) | BDBM50236068
((R)-3-(2-(1-(3-cyano-5-methylphenyl)propylamino)-3...)Show SMILES CC[C@@H](Nc1c(Nc2cccc(C(=O)N(C)C)c2O)c(=O)c1=O)c1cc(C)cc(c1)C#N Show InChI InChI=1S/C24H24N4O4/c1-5-17(15-10-13(2)9-14(11-15)12-25)26-19-20(23(31)22(19)30)27-18-8-6-7-16(21(18)29)24(32)28(3)4/h6-11,17,26-27,29H,5H2,1-4H3/t17-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 1.90 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmacopeia, Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I]IL8 from human CXCR2 by SPA assay |
Bioorg Med Chem Lett 18: 1864-8 (2008)
Article DOI: 10.1016/j.bmcl.2008.02.010
BindingDB Entry DOI: 10.7270/Q2CC10DK |
More data for this
Ligand-Target Pair | |
C-X-C chemokine receptor type 2
(Homo sapiens (Human)) | BDBM50236064
((R)-3-(2-(1-(3,5-difluorophenyl)-2-methylpropylami...)Show SMILES CC(C)[C@@H](Nc1c(Nc2cccc(C(=O)N(C)C)c2O)c(=O)c1=O)c1cc(F)cc(F)c1 Show InChI InChI=1S/C23H23F2N3O4/c1-11(2)17(12-8-13(24)10-14(25)9-12)27-19-18(21(30)22(19)31)26-16-7-5-6-15(20(16)29)23(32)28(3)4/h5-11,17,26-27,29H,1-4H3/t17-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 1.90 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmacopeia, Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I]IL8 from human CXCR2 by SPA assay |
Bioorg Med Chem Lett 18: 1864-8 (2008)
Article DOI: 10.1016/j.bmcl.2008.02.010
BindingDB Entry DOI: 10.7270/Q2CC10DK |
More data for this
Ligand-Target Pair | |
C-X-C chemokine receptor type 2
(Homo sapiens (Human)) | BDBM50248403
((S)-3-(2-(2,2-difluoro-1-(4-isopropylfuran-2-yl)pr...)Show SMILES CC(C)c1coc(c1)[C@H](Nc1c(Nc2cccc(C(=O)N(C)C)c2O)c(=O)c1=O)C(C)(F)F |r| Show InChI InChI=1S/C23H25F2N3O5/c1-11(2)12-9-15(33-10-12)21(23(3,24)25)27-17-16(19(30)20(17)31)26-14-8-6-7-13(18(14)29)22(32)28(4)5/h6-11,21,26-27,29H,1-5H3/t21-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 2 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Binding affinity to CXCR2 (unknown origin) |
Bioorg Med Chem Lett 19: 1431-3 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.033
BindingDB Entry DOI: 10.7270/Q2CV4HMF |
More data for this
Ligand-Target Pair | |
C-X-C chemokine receptor type 2
(Homo sapiens (Human)) | BDBM50211453
((R)-3-(2-(1-(4-butylfuran-2-yl)propylamino)-3,4-di...)Show SMILES CCCCc1coc(c1)[C@@H](CC)Nc1c(Nc2cccc(C(=O)N(C)C)c2O)c(=O)c1=O Show InChI InChI=1S/C24H29N3O5/c1-5-7-9-14-12-18(32-13-14)16(6-2)25-19-20(23(30)22(19)29)26-17-11-8-10-15(21(17)28)24(31)27(3)4/h8,10-13,16,25-26,28H,5-7,9H2,1-4H3/t16-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 2 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Schering Plough Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]IL8 from human CXCR2 expressed in CHO cells by SPA |
Bioorg Med Chem Lett 17: 3778-83 (2007)
Article DOI: 10.1016/j.bmcl.2007.04.016
BindingDB Entry DOI: 10.7270/Q25D8RH5 |
More data for this
Ligand-Target Pair | |
C-X-C chemokine receptor type 2
(Homo sapiens (Human)) | BDBM50211456
((R)-2-hydroxy-3-(2-(1-(4-isopropylfuran-2-yl)ethyl...)Show SMILES CC(C)c1coc(c1)[C@@H](C)Nc1c(Nc2cccc(C(=O)N(C)C)c2O)c(=O)c1=O Show InChI InChI=1S/C22H25N3O5/c1-11(2)13-9-16(30-10-13)12(3)23-17-18(21(28)20(17)27)24-15-8-6-7-14(19(15)26)22(29)25(4)5/h6-12,23-24,26H,1-5H3/t12-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 2 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Schering Plough Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]IL8 from human CXCR2 expressed in CHO cells by SPA |
Bioorg Med Chem Lett 17: 3778-83 (2007)
Article DOI: 10.1016/j.bmcl.2007.04.016
BindingDB Entry DOI: 10.7270/Q25D8RH5 |
More data for this
Ligand-Target Pair | |
C-X-C chemokine receptor type 2
(Homo sapiens (Human)) | BDBM50248279
((S)-3-(3,4-dioxo-2-(2,2,2-trifluoro-1-(furan-2-yl)...)Show SMILES CN(C)C(=O)c1cccc(Nc2c(N[C@@H](c3ccco3)C(F)(F)F)c(=O)c2=O)c1O |r| Show InChI InChI=1S/C19H16F3N3O5/c1-25(2)18(29)9-5-3-6-10(14(9)26)23-12-13(16(28)15(12)27)24-17(19(20,21)22)11-7-4-8-30-11/h3-8,17,23-24,26H,1-2H3/t17-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 2 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Binding affinity to CXCR2 (unknown origin) |
Bioorg Med Chem Lett 19: 1431-3 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.033
BindingDB Entry DOI: 10.7270/Q2CV4HMF |
More data for this
Ligand-Target Pair | |
C-X-C chemokine receptor type 2
(Homo sapiens (Human)) | BDBM50236059
((R)-3-(2-(1-(3-fluoro-5-methylphenyl)propylamino)-...)Show SMILES CC[C@@H](Nc1c(Nc2cccc(C(=O)N(C)C)c2O)c(=O)c1=O)c1cc(C)cc(F)c1 Show InChI InChI=1S/C23H24FN3O4/c1-5-16(13-9-12(2)10-14(24)11-13)25-18-19(22(30)21(18)29)26-17-8-6-7-15(20(17)28)23(31)27(3)4/h6-11,16,25-26,28H,5H2,1-4H3/t16-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 2.80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmacopeia, Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I]IL8 from human CXCR2 by SPA assay |
Bioorg Med Chem Lett 18: 1864-8 (2008)
Article DOI: 10.1016/j.bmcl.2008.02.010
BindingDB Entry DOI: 10.7270/Q2CC10DK |
More data for this
Ligand-Target Pair | |
C-X-C chemokine receptor type 2
(Homo sapiens (Human)) | BDBM50297764
((R)-5-cyano-3-(3,4-dioxo-2-(1-phenylpropylamino)cy...)Show SMILES CC[C@@H](Nc1c(Nc2cc(cc(C(=O)N(C)C)c2O)C#N)c(=O)c1=O)c1ccccc1 |r| Show InChI InChI=1S/C23H22N4O4/c1-4-16(14-8-6-5-7-9-14)25-18-19(22(30)21(18)29)26-17-11-13(12-24)10-15(20(17)28)23(31)27(2)3/h5-11,16,25-26,28H,4H2,1-3H3/t16-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Displacement of human [125I]IL-8 from human CXCR2 |
Bioorg Med Chem Lett 19: 4446-9 (2009)
Article DOI: 10.1016/j.bmcl.2009.05.049
BindingDB Entry DOI: 10.7270/Q2H1323X |
More data for this
Ligand-Target Pair | |
C-X-C chemokine receptor type 2
(Homo sapiens (Human)) | BDBM50211450
((R)-3-(2-(1-(4-cyclopentylfuran-2-yl)propylamino)-...)Show SMILES CC[C@@H](Nc1c(Nc2cccc(C(=O)N(C)C)c2O)c(=O)c1=O)c1cc(co1)C1CCCC1 Show InChI InChI=1S/C25H29N3O5/c1-4-17(19-12-15(13-33-19)14-8-5-6-9-14)26-20-21(24(31)23(20)30)27-18-11-7-10-16(22(18)29)25(32)28(2)3/h7,10-14,17,26-27,29H,4-6,8-9H2,1-3H3/t17-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Schering Plough Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]IL8 from human CXCR2 expressed in CHO cells by SPA |
Bioorg Med Chem Lett 17: 3778-83 (2007)
Article DOI: 10.1016/j.bmcl.2007.04.016
BindingDB Entry DOI: 10.7270/Q25D8RH5 |
More data for this
Ligand-Target Pair | |
C-X-C chemokine receptor type 2
(Homo sapiens (Human)) | BDBM50211462
((R)-3-(2-(cyclopropyl(4-isopropylfuran-2-yl)methyl...)Show SMILES CC(C)c1coc(c1)[C@H](Nc1c(Nc2cccc(C(=O)N(C)C)c2O)c(=O)c1=O)C1CC1 Show InChI InChI=1S/C24H27N3O5/c1-12(2)14-10-17(32-11-14)18(13-8-9-13)26-20-19(22(29)23(20)30)25-16-7-5-6-15(21(16)28)24(31)27(3)4/h5-7,10-13,18,25-26,28H,8-9H2,1-4H3/t18-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
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| CHEMBL
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PC sid
UniChem
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| Article
PubMed
| 3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Schering Plough Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]IL8 from human CXCR2 expressed in CHO cells by SPA |
Bioorg Med Chem Lett 17: 3778-83 (2007)
Article DOI: 10.1016/j.bmcl.2007.04.016
BindingDB Entry DOI: 10.7270/Q25D8RH5 |
More data for this
Ligand-Target Pair | |
C-X-C chemokine receptor type 1
(Homo sapiens (Human)) | BDBM50211458
((R)-2-hydroxy-3-(2-(1-(4-isopropylfuran-2-yl)propy...)Show SMILES CC[C@@H](Nc1c(Nc2cccc(C(=O)N(C)C)c2O)c(=O)c1=O)c1cc(co1)C(C)C Show InChI InChI=1S/C23H27N3O5/c1-6-15(17-10-13(11-31-17)12(2)3)24-18-19(22(29)21(18)28)25-16-9-7-8-14(20(16)27)23(30)26(4)5/h7-12,15,24-25,27H,6H2,1-5H3/t15-/m1/s1 | PDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Schering Plough Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]IL8 from human CXCR1 expressed in CHO cells by SPA |
Bioorg Med Chem Lett 17: 3778-83 (2007)
Article DOI: 10.1016/j.bmcl.2007.04.016
BindingDB Entry DOI: 10.7270/Q25D8RH5 |
More data for this
Ligand-Target Pair | |
C-X-C chemokine receptor type 2
(Homo sapiens (Human)) | BDBM50211459
((R)-3-(2-(1-(4-cyclohexylfuran-2-yl)propylamino)-3...)Show SMILES CC[C@@H](Nc1c(Nc2cccc(C(=O)N(C)C)c2O)c(=O)c1=O)c1cc(co1)C1CCCCC1 Show InChI InChI=1S/C26H31N3O5/c1-4-18(20-13-16(14-34-20)15-9-6-5-7-10-15)27-21-22(25(32)24(21)31)28-19-12-8-11-17(23(19)30)26(33)29(2)3/h8,11-15,18,27-28,30H,4-7,9-10H2,1-3H3/t18-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Schering Plough Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]IL8 from human CXCR2 expressed in CHO cells by SPA |
Bioorg Med Chem Lett 17: 3778-83 (2007)
Article DOI: 10.1016/j.bmcl.2007.04.016
BindingDB Entry DOI: 10.7270/Q25D8RH5 |
More data for this
Ligand-Target Pair | |
C-X-C chemokine receptor type 2
(Homo sapiens (Human)) | BDBM50211448
((R)-2-hydroxy-3-(2-(1-(4-isopropylfuran-2-yl)-2,2-...)Show SMILES CC(C)c1coc(c1)[C@H](Nc1c(Nc2cccc(C(=O)N(C)C)c2O)c(=O)c1=O)C(C)(C)C Show InChI InChI=1S/C25H31N3O5/c1-13(2)14-11-17(33-12-14)23(25(3,4)5)27-19-18(21(30)22(19)31)26-16-10-8-9-15(20(16)29)24(32)28(6)7/h8-13,23,26-27,29H,1-7H3/t23-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Schering Plough Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]IL8 from human CXCR2 expressed in CHO cells by SPA |
Bioorg Med Chem Lett 17: 3778-83 (2007)
Article DOI: 10.1016/j.bmcl.2007.04.016
BindingDB Entry DOI: 10.7270/Q25D8RH5 |
More data for this
Ligand-Target Pair | |
C-X-C chemokine receptor type 2
(Homo sapiens (Human)) | BDBM50211464
((R)-2-hydroxy-N,N-dimethyl-3-(2-(1-(4-methylfuran-...)Show SMILES CC[C@@H](Nc1c(Nc2cccc(C(=O)N(C)C)c2O)c(=O)c1=O)c1cc(C)co1 Show InChI InChI=1S/C21H23N3O5/c1-5-13(15-9-11(2)10-29-15)22-16-17(20(27)19(16)26)23-14-8-6-7-12(18(14)25)21(28)24(3)4/h6-10,13,22-23,25H,5H2,1-4H3/t13-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Schering Plough Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]IL8 from human CXCR2 expressed in CHO cells by SPA |
Bioorg Med Chem Lett 17: 3778-83 (2007)
Article DOI: 10.1016/j.bmcl.2007.04.016
BindingDB Entry DOI: 10.7270/Q25D8RH5 |
More data for this
Ligand-Target Pair | |
C-X-C chemokine receptor type 2
(Homo sapiens (Human)) | BDBM50211455
((R)-3-(2-(1-(4-tert-butylfuran-2-yl)propylamino)-3...)Show SMILES CC[C@@H](Nc1c(Nc2cccc(C(=O)N(C)C)c2O)c(=O)c1=O)c1cc(co1)C(C)(C)C Show InChI InChI=1S/C24H29N3O5/c1-7-15(17-11-13(12-32-17)24(2,3)4)25-18-19(22(30)21(18)29)26-16-10-8-9-14(20(16)28)23(31)27(5)6/h8-12,15,25-26,28H,7H2,1-6H3/t15-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Schering Plough Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]IL8 from human CXCR2 expressed in CHO cells by SPA |
Bioorg Med Chem Lett 17: 3778-83 (2007)
Article DOI: 10.1016/j.bmcl.2007.04.016
BindingDB Entry DOI: 10.7270/Q25D8RH5 |
More data for this
Ligand-Target Pair | |
C-X-C chemokine receptor type 2
(Homo sapiens (Human)) | BDBM50200880
((R)-2-hydroxy-N,N-dimethyl-3-(2-(1-(5-methylfuran-...)Show SMILES CC[C@@H](Nc1c(Nc2cccc(C(=O)N(C)C)c2O)c(=O)c1=O)c1ccc(C)o1 |r| Show InChI InChI=1S/C21H23N3O5/c1-5-13(15-10-9-11(2)29-15)22-16-17(20(27)19(16)26)23-14-8-6-7-12(18(14)25)21(28)24(3)4/h6-10,13,22-23,25H,5H2,1-4H3/t13-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Patents
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| Article
PubMed
| 4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Binding affinity to CXCR2 (unknown origin) |
Bioorg Med Chem Lett 19: 1431-3 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.033
BindingDB Entry DOI: 10.7270/Q2CV4HMF |
More data for this
Ligand-Target Pair | |
C-X-C chemokine receptor type 2
(Homo sapiens (Human)) | BDBM50248336
(3-(2-((1S,2S)-2-fluoro-1-(4-methylfuran-2-yl)propy...)Show SMILES C[C@H](F)[C@@H](Nc1c(Nc2cccc(C(=O)N(C)C)c2O)c(=O)c1=O)c1cc(C)co1 |r| Show InChI InChI=1S/C21H22FN3O5/c1-10-8-14(30-9-10)15(11(2)22)24-17-16(19(27)20(17)28)23-13-7-5-6-12(18(13)26)21(29)25(3)4/h5-9,11,15,23-24,26H,1-4H3/t11-,15+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Binding affinity to CXCR2 (unknown origin) |
Bioorg Med Chem Lett 19: 1431-3 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.033
BindingDB Entry DOI: 10.7270/Q2CV4HMF |
More data for this
Ligand-Target Pair | |
C-X-C chemokine receptor type 2
(Homo sapiens (Human)) | BDBM50248456
((S)-3-(3,4-dioxo-2-(2,2,3,3,3-pentafluoro-1-(5-met...)Show SMILES CN(C)C(=O)c1cccc(Nc2c(N[C@@H](c3ccc(C)o3)C(F)(F)C(F)(F)F)c(=O)c2=O)c1O |r| Show InChI InChI=1S/C21H18F5N3O5/c1-9-7-8-12(34-9)18(20(22,23)21(24,25)26)28-14-13(16(31)17(14)32)27-11-6-4-5-10(15(11)30)19(33)29(2)3/h4-8,18,27-28,30H,1-3H3/t18-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Binding affinity to CXCR2 (unknown origin) |
Bioorg Med Chem Lett 19: 1431-3 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.033
BindingDB Entry DOI: 10.7270/Q2CV4HMF |
More data for this
Ligand-Target Pair | |
C-X-C chemokine receptor type 2
(Homo sapiens (Human)) | BDBM50236053
((R)-3-(3,4-dioxo-2-(1-phenylpropylamino)cyclobut-1...)Show SMILES CC[C@@H](Nc1c(Nc2cccc(C(=O)N(C)C)c2O)c(=O)c1=O)c1ccccc1 |r| Show InChI InChI=1S/C22H23N3O4/c1-4-15(13-9-6-5-7-10-13)23-17-18(21(28)20(17)27)24-16-12-8-11-14(19(16)26)22(29)25(2)3/h5-12,15,23-24,26H,4H2,1-3H3/t15-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Binding affinity to CXCR2 (unknown origin) |
Bioorg Med Chem Lett 19: 1431-3 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.033
BindingDB Entry DOI: 10.7270/Q2CV4HMF |
More data for this
Ligand-Target Pair | |
C-X-C chemokine receptor type 2
(Homo sapiens (Human)) | BDBM50297761
((R)-6-bromo-3-(3,4-dioxo-2-(1-phenylpropylamino)cy...)Show SMILES CC[C@@H](Nc1c(Nc2ccc(Br)c(C(=O)N(C)C)c2O)c(=O)c1=O)c1ccccc1 |r| Show InChI InChI=1S/C22H22BrN3O4/c1-4-14(12-8-6-5-7-9-12)24-17-18(21(29)20(17)28)25-15-11-10-13(23)16(19(15)27)22(30)26(2)3/h5-11,14,24-25,27H,4H2,1-3H3/t14-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Displacement of human [125I]IL-8 from human CXCR2 |
Bioorg Med Chem Lett 19: 4446-9 (2009)
Article DOI: 10.1016/j.bmcl.2009.05.049
BindingDB Entry DOI: 10.7270/Q2H1323X |
More data for this
Ligand-Target Pair | |
C-X-C chemokine receptor type 2
(Homo sapiens (Human)) | BDBM50211452
((R)-2-hydroxy-3-(2-(1-(4-isopropylfuran-2-yl)-2-me...)Show SMILES CC(C)[C@@H](Nc1c(Nc2cccc(C(=O)N(C)C)c2O)c(=O)c1=O)c1cc(co1)C(C)C Show InChI InChI=1S/C24H29N3O5/c1-12(2)14-10-17(32-11-14)18(13(3)4)26-20-19(22(29)23(20)30)25-16-9-7-8-15(21(16)28)24(31)27(5)6/h7-13,18,25-26,28H,1-6H3/t18-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Schering Plough Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]IL8 from human CXCR2 expressed in CHO cells by SPA |
Bioorg Med Chem Lett 17: 3778-83 (2007)
Article DOI: 10.1016/j.bmcl.2007.04.016
BindingDB Entry DOI: 10.7270/Q25D8RH5 |
More data for this
Ligand-Target Pair | |
C-X-C chemokine receptor type 2
(Homo sapiens (Human)) | BDBM50236062
((R)-2-hydroxy-N,N-dimethyl-3-(2-(2-methyl-1-(3-met...)Show SMILES CC(C)[C@@H](Nc1c(Nc2cccc(C(=O)N(C)C)c2O)c(=O)c1=O)c1cc(C)cc(c1)C(F)(F)F Show InChI InChI=1S/C25H26F3N3O4/c1-12(2)18(14-9-13(3)10-15(11-14)25(26,27)28)30-20-19(22(33)23(20)34)29-17-8-6-7-16(21(17)32)24(35)31(4)5/h6-12,18,29-30,32H,1-5H3/t18-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 4.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmacopeia, Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I]IL8 from human CXCR2 by SPA assay |
Bioorg Med Chem Lett 18: 1864-8 (2008)
Article DOI: 10.1016/j.bmcl.2008.02.010
BindingDB Entry DOI: 10.7270/Q2CC10DK |
More data for this
Ligand-Target Pair | |
C-X-C chemokine receptor type 2
(Homo sapiens (Human)) | BDBM50236053
((R)-3-(3,4-dioxo-2-(1-phenylpropylamino)cyclobut-1...)Show SMILES CC[C@@H](Nc1c(Nc2cccc(C(=O)N(C)C)c2O)c(=O)c1=O)c1ccccc1 |r| Show InChI InChI=1S/C22H23N3O4/c1-4-15(13-9-6-5-7-10-13)23-17-18(21(28)20(17)27)24-16-12-8-11-14(19(16)26)22(29)25(2)3/h5-12,15,23-24,26H,4H2,1-3H3/t15-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 4.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Displacement of human [125I]IL-8 from human CXCR2 |
Bioorg Med Chem Lett 19: 4446-9 (2009)
Article DOI: 10.1016/j.bmcl.2009.05.049
BindingDB Entry DOI: 10.7270/Q2H1323X |
More data for this
Ligand-Target Pair | |
C-X-C chemokine receptor type 2
(Homo sapiens (Human)) | BDBM50236052
((R)-3-(2-(cyclopropyl(3,5-difluorophenyl)methylami...)Show SMILES CN(C)C(=O)c1cccc(Nc2c(N[C@H](C3CC3)c3cc(F)cc(F)c3)c(=O)c2=O)c1O Show InChI InChI=1S/C23H21F2N3O4/c1-28(2)23(32)15-4-3-5-16(20(15)29)26-18-19(22(31)21(18)30)27-17(11-6-7-11)12-8-13(24)10-14(25)9-12/h3-5,8-11,17,26-27,29H,6-7H2,1-2H3/t17-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 4.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmacopeia, Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I]IL8 from human CXCR2 by SPA assay |
Bioorg Med Chem Lett 18: 1864-8 (2008)
Article DOI: 10.1016/j.bmcl.2008.02.010
BindingDB Entry DOI: 10.7270/Q2CC10DK |
More data for this
Ligand-Target Pair | |
C-X-C chemokine receptor type 2
(Homo sapiens (Human)) | BDBM50297740
((R)-3-(3,4-dioxo-2-(1-phenylpropylamino)cyclobut-1...)Show SMILES CC[C@@H](Nc1c(Nc2c(C)ccc(C(=O)N(C)C)c2O)c(=O)c1=O)c1ccccc1 |r| Show InChI InChI=1S/C23H25N3O4/c1-5-16(14-9-7-6-8-10-14)24-18-19(22(29)21(18)28)25-17-13(2)11-12-15(20(17)27)23(30)26(3)4/h6-12,16,24-25,27H,5H2,1-4H3/t16-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 4.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Displacement of human [125I]IL-8 from human CXCR2 |
Bioorg Med Chem Lett 19: 4446-9 (2009)
Article DOI: 10.1016/j.bmcl.2009.05.049
BindingDB Entry DOI: 10.7270/Q2H1323X |
More data for this
Ligand-Target Pair | |
C-X-C chemokine receptor type 2
(Homo sapiens (Human)) | BDBM50236053
((R)-3-(3,4-dioxo-2-(1-phenylpropylamino)cyclobut-1...)Show SMILES CC[C@@H](Nc1c(Nc2cccc(C(=O)N(C)C)c2O)c(=O)c1=O)c1ccccc1 |r| Show InChI InChI=1S/C22H23N3O4/c1-4-15(13-9-6-5-7-10-13)23-17-18(21(28)20(17)27)24-16-12-8-11-14(19(16)26)22(29)25(2)3/h5-12,15,23-24,26H,4H2,1-3H3/t15-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 4.70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmacopeia, Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I]IL8 from human CXCR2 by SPA assay |
Bioorg Med Chem Lett 18: 1864-8 (2008)
Article DOI: 10.1016/j.bmcl.2008.02.010
BindingDB Entry DOI: 10.7270/Q2CC10DK |
More data for this
Ligand-Target Pair | |
C-X-C chemokine receptor type 2
(Homo sapiens (Human)) | BDBM50200880
((R)-2-hydroxy-N,N-dimethyl-3-(2-(1-(5-methylfuran-...)Show SMILES CC[C@@H](Nc1c(Nc2cccc(C(=O)N(C)C)c2O)c(=O)c1=O)c1ccc(C)o1 |r| Show InChI InChI=1S/C21H23N3O5/c1-5-13(15-10-9-11(2)29-15)22-16-17(20(27)19(16)26)23-14-8-6-7-12(18(14)25)21(28)24(3)4/h6-10,13,22-23,25H,5H2,1-4H3/t13-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
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GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Patents
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| Article
PubMed
| 5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Displacement of human [125I]IL-8 from human CXCR2 |
Bioorg Med Chem Lett 19: 4446-9 (2009)
Article DOI: 10.1016/j.bmcl.2009.05.049
BindingDB Entry DOI: 10.7270/Q2H1323X |
More data for this
Ligand-Target Pair | |
C-X-C chemokine receptor type 2
(Homo sapiens (Human)) | BDBM50297738
((R)-1-(3-(3,4-dioxo-2-(1-phenylpropylamino)cyclobu...)Show SMILES CC[C@@H](Nc1c(Nc2cccc(C(=O)N3CCCC3C(O)=O)c2O)c(=O)c1=O)c1ccccc1 |r| Show InChI InChI=1S/C25H25N3O6/c1-2-16(14-8-4-3-5-9-14)26-19-20(23(31)22(19)30)27-17-11-6-10-15(21(17)29)24(32)28-13-7-12-18(28)25(33)34/h3-6,8-11,16,18,26-27,29H,2,7,12-13H2,1H3,(H,33,34)/t16-,18?/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Displacement of human [125I]IL-8 from human CXCR2 |
Bioorg Med Chem Lett 19: 4446-9 (2009)
Article DOI: 10.1016/j.bmcl.2009.05.049
BindingDB Entry DOI: 10.7270/Q2H1323X |
More data for this
Ligand-Target Pair | |
C-X-C chemokine receptor type 2
(Homo sapiens (Human)) | BDBM50200887
((R)-3-(3,4-dioxo-2-(1-(thiophen-2-yl)propylamino)c...)Show SMILES CC[C@@H](Nc1c(Nc2cccc(C(=O)N(C)C)c2O)c(=O)c1=O)c1cccs1 |r| Show InChI InChI=1S/C20H21N3O4S/c1-4-12(14-9-6-10-28-14)21-15-16(19(26)18(15)25)22-13-8-5-7-11(17(13)24)20(27)23(2)3/h5-10,12,21-22,24H,4H2,1-3H3/t12-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Displacement of human [125I]IL-8 from human CXCR2 |
Bioorg Med Chem Lett 19: 4446-9 (2009)
Article DOI: 10.1016/j.bmcl.2009.05.049
BindingDB Entry DOI: 10.7270/Q2H1323X |
More data for this
Ligand-Target Pair | |
C-X-C chemokine receptor type 2
(Homo sapiens (Human)) | BDBM50297741
((R)-5-cyano-3-(3,4-dioxo-2-(1-(thiophen-2-yl)propy...)Show SMILES CC[C@@H](Nc1c(Nc2cc(cc(C(=O)N(C)C)c2O)C#N)c(=O)c1=O)c1cccs1 |r| Show InChI InChI=1S/C21H20N4O4S/c1-4-13(15-6-5-7-30-15)23-16-17(20(28)19(16)27)24-14-9-11(10-22)8-12(18(14)26)21(29)25(2)3/h5-9,13,23-24,26H,4H2,1-3H3/t13-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Displacement of human [125I]IL-8 from human CXCR2 |
Bioorg Med Chem Lett 19: 4446-9 (2009)
Article DOI: 10.1016/j.bmcl.2009.05.049
BindingDB Entry DOI: 10.7270/Q2H1323X |
More data for this
Ligand-Target Pair | |
C-X-C chemokine receptor type 2
(Homo sapiens (Human)) | BDBM50248280
((S)-3-(3,4-dioxo-2-(2,2,2-trifluoro-1-(5-methylfur...)Show SMILES CN(C)C(=O)c1cccc(Nc2c(N[C@@H](c3ccc(C)o3)C(F)(F)F)c(=O)c2=O)c1O |r| Show InChI InChI=1S/C20H18F3N3O5/c1-9-7-8-12(31-9)18(20(21,22)23)25-14-13(16(28)17(14)29)24-11-6-4-5-10(15(11)27)19(30)26(2)3/h4-8,18,24-25,27H,1-3H3/t18-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Binding affinity to CXCR2 (unknown origin) |
Bioorg Med Chem Lett 19: 1431-3 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.033
BindingDB Entry DOI: 10.7270/Q2CV4HMF |
More data for this
Ligand-Target Pair | |
C-X-C chemokine receptor type 2
(Homo sapiens (Human)) | BDBM50248281
((R)-3-(3,4-dioxo-2-(3,3,3-trifluoro-1-(furan-2-yl)...)Show SMILES CN(C)C(=O)c1cccc(Nc2c(N[C@H](CC(F)(F)F)c3ccco3)c(=O)c2=O)c1O |r| Show InChI InChI=1S/C20H18F3N3O5/c1-26(2)19(30)10-5-3-6-11(16(10)27)24-14-15(18(29)17(14)28)25-12(9-20(21,22)23)13-7-4-8-31-13/h3-8,12,24-25,27H,9H2,1-2H3/t12-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Binding affinity to CXCR2 (unknown origin) |
Bioorg Med Chem Lett 19: 1431-3 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.033
BindingDB Entry DOI: 10.7270/Q2CV4HMF |
More data for this
Ligand-Target Pair | |
C-X-C chemokine receptor type 2
(Homo sapiens (Human)) | BDBM50248453
((S)-3-(2-(2,2-difluoro-1-(5-methylfuran-2-yl)butyl...)Show SMILES CCC(F)(F)[C@@H](Nc1c(Nc2cccc(C(=O)N(C)C)c2O)c(=O)c1=O)c1ccc(C)o1 |r| Show InChI InChI=1S/C22H23F2N3O5/c1-5-22(23,24)20(14-10-9-11(2)32-14)26-16-15(18(29)19(16)30)25-13-8-6-7-12(17(13)28)21(31)27(3)4/h6-10,20,25-26,28H,5H2,1-4H3/t20-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Binding affinity to CXCR2 (unknown origin) |
Bioorg Med Chem Lett 19: 1431-3 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.033
BindingDB Entry DOI: 10.7270/Q2CV4HMF |
More data for this
Ligand-Target Pair | |
C-X-C chemokine receptor type 2
(Homo sapiens (Human)) | BDBM50248501
((S)-3-(2-(1-(4,5-dichlorofuran-2-yl)-2,2,2-trifluo...)Show SMILES CN(C)C(=O)c1cccc(Nc2c(N[C@@H](c3cc(Cl)c(Cl)o3)C(F)(F)F)c(=O)c2=O)c1O |r| Show InChI InChI=1S/C19H14Cl2F3N3O5/c1-27(2)18(31)7-4-3-5-9(13(7)28)25-11-12(15(30)14(11)29)26-16(19(22,23)24)10-6-8(20)17(21)32-10/h3-6,16,25-26,28H,1-2H3/t16-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Binding affinity to CXCR2 (unknown origin) |
Bioorg Med Chem Lett 19: 1431-3 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.033
BindingDB Entry DOI: 10.7270/Q2CV4HMF |
More data for this
Ligand-Target Pair | |
C-X-C chemokine receptor type 2
(Homo sapiens (Human)) | BDBM50248502
((S)-3-(2-(1-(4-chlorofuran-2-yl)-2,2,2-trifluoroet...)Show SMILES CN(C)C(=O)c1cccc(Nc2c(N[C@@H](c3cc(Cl)co3)C(F)(F)F)c(=O)c2=O)c1O |r| Show InChI InChI=1S/C19H15ClF3N3O5/c1-26(2)18(30)9-4-3-5-10(14(9)27)24-12-13(16(29)15(12)28)25-17(19(21,22)23)11-6-8(20)7-31-11/h3-7,17,24-25,27H,1-2H3/t17-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Binding affinity to CXCR2 (unknown origin) |
Bioorg Med Chem Lett 19: 1431-3 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.033
BindingDB Entry DOI: 10.7270/Q2CV4HMF |
More data for this
Ligand-Target Pair | |
C-X-C chemokine receptor type 2
(Homo sapiens (Human)) | BDBM50248545
((S)-3-(2-(1-(benzo[d][1,3]dioxol-5-yl)-2,2,2-trifl...)Show SMILES CN(C)C(=O)c1cccc(Nc2c(N[C@@H](c3ccc4OCOc4c3)C(F)(F)F)c(=O)c2=O)c1O |r| Show InChI InChI=1S/C22H18F3N3O6/c1-28(2)21(32)11-4-3-5-12(17(11)29)26-15-16(19(31)18(15)30)27-20(22(23,24)25)10-6-7-13-14(8-10)34-9-33-13/h3-8,20,26-27,29H,9H2,1-2H3/t20-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Binding affinity to CXCR2 (unknown origin) |
Bioorg Med Chem Lett 19: 1431-3 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.033
BindingDB Entry DOI: 10.7270/Q2CV4HMF |
More data for this
Ligand-Target Pair | |
C-X-C chemokine receptor type 1
(Homo sapiens (Human)) | BDBM50248336
(3-(2-((1S,2S)-2-fluoro-1-(4-methylfuran-2-yl)propy...)Show SMILES C[C@H](F)[C@@H](Nc1c(Nc2cccc(C(=O)N(C)C)c2O)c(=O)c1=O)c1cc(C)co1 |r| Show InChI InChI=1S/C21H22FN3O5/c1-10-8-14(30-9-10)15(11(2)22)24-17-16(19(27)20(17)28)23-13-7-5-6-12(18(13)26)21(29)25(3)4/h5-9,11,15,23-24,26H,1-4H3/t11-,15+/m0/s1 | PDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Binding affinity to CXCR1 (unknown origin) |
Bioorg Med Chem Lett 19: 1431-3 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.033
BindingDB Entry DOI: 10.7270/Q2CV4HMF |
More data for this
Ligand-Target Pair | |
C-X-C chemokine receptor type 2
(Homo sapiens (Human)) | BDBM50200880
((R)-2-hydroxy-N,N-dimethyl-3-(2-(1-(5-methylfuran-...)Show SMILES CC[C@@H](Nc1c(Nc2cccc(C(=O)N(C)C)c2O)c(=O)c1=O)c1ccc(C)o1 |r| Show InChI InChI=1S/C21H23N3O5/c1-5-13(15-10-9-11(2)29-15)22-16-17(20(27)19(16)26)23-14-8-6-7-12(18(14)25)21(28)24(3)4/h6-10,13,22-23,25H,5H2,1-4H3/t13-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Schering Plough Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]IL8 from human CXCR2 expressed in CHO cells by SPA |
Bioorg Med Chem Lett 17: 3778-83 (2007)
Article DOI: 10.1016/j.bmcl.2007.04.016
BindingDB Entry DOI: 10.7270/Q25D8RH5 |
More data for this
Ligand-Target Pair | |
C-X-C chemokine receptor type 2
(Homo sapiens (Human)) | BDBM50211451
((R)-2-hydroxy-N,N-dimethyl-3-(2-(1-(4-methylthioph...)Show SMILES CC[C@@H](Nc1c(Nc2cccc(C(=O)N(C)C)c2O)c(=O)c1=O)c1cc(C)cs1 Show InChI InChI=1S/C21H23N3O4S/c1-5-13(15-9-11(2)10-29-15)22-16-17(20(27)19(16)26)23-14-8-6-7-12(18(14)25)21(28)24(3)4/h6-10,13,22-23,25H,5H2,1-4H3/t13-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Schering Plough Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]IL8 from human CXCR2 expressed in CHO cells by SPA |
Bioorg Med Chem Lett 17: 3778-83 (2007)
Article DOI: 10.1016/j.bmcl.2007.04.016
BindingDB Entry DOI: 10.7270/Q25D8RH5 |
More data for this
Ligand-Target Pair | |
C-X-C chemokine receptor type 2
(Homo sapiens (Human)) | BDBM50200877
((R)-2-hydroxy-N,N-dimethyl-3-(2-(1-(5-methylthioph...)Show SMILES CC[C@@H](Nc1c(Nc2cccc(C(=O)N(C)C)c2O)c(=O)c1=O)c1ccc(C)s1 |r| Show InChI InChI=1S/C21H23N3O4S/c1-5-13(15-10-9-11(2)29-15)22-16-17(20(27)19(16)26)23-14-8-6-7-12(18(14)25)21(28)24(3)4/h6-10,13,22-23,25H,5H2,1-4H3/t13-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Schering Plough Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]IL8 from human CXCR2 expressed in CHO cells by SPA |
Bioorg Med Chem Lett 17: 3778-83 (2007)
Article DOI: 10.1016/j.bmcl.2007.04.016
BindingDB Entry DOI: 10.7270/Q25D8RH5 |
More data for this
Ligand-Target Pair | |
C-X-C chemokine receptor type 2
(Homo sapiens (Human)) | BDBM50236061
((R)-3-(2-(1-(3-fluoro-4-methoxyphenyl)propylamino)...)Show SMILES CC[C@@H](Nc1c(Nc2cccc(C(=O)N(C)C)c2O)c(=O)c1=O)c1ccc(OC)c(F)c1 Show InChI InChI=1S/C23H24FN3O5/c1-5-15(12-9-10-17(32-4)14(24)11-12)25-18-19(22(30)21(18)29)26-16-8-6-7-13(20(16)28)23(31)27(2)3/h6-11,15,25-26,28H,5H2,1-4H3/t15-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 5.20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmacopeia, Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I]IL8 from human CXCR2 by SPA assay |
Bioorg Med Chem Lett 18: 1864-8 (2008)
Article DOI: 10.1016/j.bmcl.2008.02.010
BindingDB Entry DOI: 10.7270/Q2CC10DK |
More data for this
Ligand-Target Pair | |
C-X-C chemokine receptor type 1
(Homo sapiens (Human)) | BDBM50248401
((S)-3-(2-(2,2-difluoro-1-(4-methylfuran-2-yl)propy...)Show SMILES CN(C)C(=O)c1cccc(Nc2c(N[C@@H](c3cc(C)co3)C(C)(F)F)c(=O)c2=O)c1O |r| Show InChI InChI=1S/C21H21F2N3O5/c1-10-8-13(31-9-10)19(21(2,22)23)25-15-14(17(28)18(15)29)24-12-7-5-6-11(16(12)27)20(30)26(3)4/h5-9,19,24-25,27H,1-4H3/t19-/m0/s1 | PDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Binding affinity to CXCR1 (unknown origin) |
Bioorg Med Chem Lett 19: 1431-3 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.033
BindingDB Entry DOI: 10.7270/Q2CV4HMF |
More data for this
Ligand-Target Pair | |
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