Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Flap endonuclease 1 [1-336] (Homo sapiens (Human)) | BDBM197162 (3-hydroxy-1-(4-methoxybenzyl)quinazoline-2,4(1H,3H...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 16.9 | n/a | n/a | n/a | n/a | 7.5 | n/a |
University of Sheffield | Assay Description Reaction mixtures containing twelve different concentrations of FAM-labeled DF1 (Supplementary Fig. 5a) substrate were prepared in reaction buffer (R... | Nat Chem Biol 12: 815-21 (2016) Article DOI: 10.1038/nchembio.2148 BindingDB Entry DOI: 10.7270/Q2RJ4H88 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Flap endonuclease 1 [1-336] (Homo sapiens (Human)) | BDBM197161 (1-(cyclopropylmethyl)-3-hydroxyquinazoline-2,4(1H,...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | 30 | n/a | n/a | n/a | n/a | 7.5 | n/a |
University of Sheffield | Assay Description Reaction mixtures containing twelve different concentrations of FAM-labeled DF1 (Supplementary Fig. 5a) substrate were prepared in reaction buffer (R... | Nat Chem Biol 12: 815-21 (2016) Article DOI: 10.1038/nchembio.2148 BindingDB Entry DOI: 10.7270/Q2RJ4H88 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Flap endonuclease 1 [1-336] (Homo sapiens (Human)) | BDBM50157840 (1-((2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)-3-...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents | PDB Article PubMed | n/a | n/a | 46.4 | n/a | n/a | n/a | n/a | 7.5 | n/a |
University of Sheffield | Assay Description Reaction mixtures containing twelve different concentrations of FAM-labeled DF1 (Supplementary Fig. 5a) substrate were prepared in reaction buffer (R... | Nat Chem Biol 12: 815-21 (2016) Article DOI: 10.1038/nchembio.2148 BindingDB Entry DOI: 10.7270/Q2RJ4H88 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Tubulin beta chain (Sus scrofa) | BDBM50500399 (CHEMBL3746906) | PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 160 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Sheffield Curated by ChEMBL | Assay Description Displacement of [3H]-colchicine from biotinylated porcine tubulin after 2 hrs by competitive binding assay | J Med Chem 58: 9309-33 (2015) Article DOI: 10.1021/acs.jmedchem.5b01312 BindingDB Entry DOI: 10.7270/Q2Z60S2S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tubulin beta chain (Sus scrofa) | BDBM50500401 (CHEMBL3746593) | PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 420 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Sheffield Curated by ChEMBL | Assay Description Displacement of [3H]-colchicine from biotinylated porcine tubulin after 2 hrs by competitive binding assay | J Med Chem 58: 9309-33 (2015) Article DOI: 10.1021/acs.jmedchem.5b01312 BindingDB Entry DOI: 10.7270/Q2Z60S2S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tubulin beta chain (Sus scrofa) | BDBM50500404 (CHEMBL3747333) | PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 500 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Sheffield Curated by ChEMBL | Assay Description Displacement of [3H]-colchicine from biotinylated porcine tubulin after 2 hrs by competitive binding assay | J Med Chem 58: 9309-33 (2015) Article DOI: 10.1021/acs.jmedchem.5b01312 BindingDB Entry DOI: 10.7270/Q2Z60S2S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tubulin beta chain (Sus scrofa) | BDBM50500403 (CHEMBL3746996) | PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 940 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Sheffield Curated by ChEMBL | Assay Description Displacement of [3H]-colchicine from biotinylated porcine tubulin after 2 hrs by competitive binding assay | J Med Chem 58: 9309-33 (2015) Article DOI: 10.1021/acs.jmedchem.5b01312 BindingDB Entry DOI: 10.7270/Q2Z60S2S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tubulin beta chain (Sus scrofa) | BDBM50500400 (CHEMBL3747196) | PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Sheffield Curated by ChEMBL | Assay Description Displacement of [3H]-colchicine from biotinylated porcine tubulin after 2 hrs by competitive binding assay | J Med Chem 58: 9309-33 (2015) Article DOI: 10.1021/acs.jmedchem.5b01312 BindingDB Entry DOI: 10.7270/Q2Z60S2S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tubulin beta chain (Sus scrofa) | BDBM50014846 ((S)-N-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-...) | PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 2.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Sheffield Curated by ChEMBL | Assay Description Inhibition of porcine brain tubulin polymerization assessed as reduction in GTP-induced microtubule assembly after 60 mins by OD340 method | J Med Chem 58: 9309-33 (2015) Article DOI: 10.1021/acs.jmedchem.5b01312 BindingDB Entry DOI: 10.7270/Q2Z60S2S | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Tubulin beta chain (Sus scrofa) | BDBM50500402 (CHEMBL3747607) | PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 2.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Sheffield Curated by ChEMBL | Assay Description Displacement of [3H]-colchicine from biotinylated porcine tubulin after 2 hrs by competitive binding assay | J Med Chem 58: 9309-33 (2015) Article DOI: 10.1021/acs.jmedchem.5b01312 BindingDB Entry DOI: 10.7270/Q2Z60S2S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tubulin beta chain (Sus scrofa) | BDBM50500403 (CHEMBL3746996) | PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 2.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Sheffield Curated by ChEMBL | Assay Description Inhibition of porcine brain tubulin polymerization assessed as reduction in GTP-induced microtubule assembly after 60 mins by OD340 method | J Med Chem 58: 9309-33 (2015) Article DOI: 10.1021/acs.jmedchem.5b01312 BindingDB Entry DOI: 10.7270/Q2Z60S2S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tubulin beta chain (Sus scrofa) | BDBM50500399 (CHEMBL3746906) | PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 3.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Sheffield Curated by ChEMBL | Assay Description Inhibition of porcine brain tubulin polymerization assessed as reduction in GTP-induced microtubule assembly after 60 mins by OD340 method | J Med Chem 58: 9309-33 (2015) Article DOI: 10.1021/acs.jmedchem.5b01312 BindingDB Entry DOI: 10.7270/Q2Z60S2S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tubulin beta chain (Sus scrofa) | BDBM50500404 (CHEMBL3747333) | PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 6.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Sheffield Curated by ChEMBL | Assay Description Inhibition of porcine brain tubulin polymerization assessed as reduction in GTP-induced microtubule assembly after 60 mins by OD340 method | J Med Chem 58: 9309-33 (2015) Article DOI: 10.1021/acs.jmedchem.5b01312 BindingDB Entry DOI: 10.7270/Q2Z60S2S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tubulin beta chain (Sus scrofa) | BDBM50500402 (CHEMBL3747607) | PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 7.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Sheffield Curated by ChEMBL | Assay Description Inhibition of porcine brain tubulin polymerization assessed as reduction in GTP-induced microtubule assembly after 60 mins by OD340 method | J Med Chem 58: 9309-33 (2015) Article DOI: 10.1021/acs.jmedchem.5b01312 BindingDB Entry DOI: 10.7270/Q2Z60S2S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tubulin beta chain (Sus scrofa) | BDBM50500401 (CHEMBL3746593) | PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 8.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Sheffield Curated by ChEMBL | Assay Description Inhibition of porcine brain tubulin polymerization assessed as reduction in GTP-induced microtubule assembly after 60 mins by OD340 method | J Med Chem 58: 9309-33 (2015) Article DOI: 10.1021/acs.jmedchem.5b01312 BindingDB Entry DOI: 10.7270/Q2Z60S2S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tubulin beta chain (Sus scrofa) | BDBM50500400 (CHEMBL3747196) | PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.49E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Sheffield Curated by ChEMBL | Assay Description Inhibition of porcine brain tubulin polymerization assessed as reduction in GTP-induced microtubule assembly after 60 mins by OD340 method | J Med Chem 58: 9309-33 (2015) Article DOI: 10.1021/acs.jmedchem.5b01312 BindingDB Entry DOI: 10.7270/Q2Z60S2S | |||||||||||
More data for this Ligand-Target Pair |