Compile Data Set for Download or QSAR

Found 1314 hits with Last Name = 'truong' and Initial = 'ap'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Presenilin-1 (Homo sapiens (Human))	BDBM50481062 (CHEMBL583904) Show SMILES Clc1ccc(cc1)S(=O)(=O)N1C(C2CC2)c2c[nH]nc2-c2ccccc12 Show InChI InChI=1S/C19H16ClN3O2S/c20-13-7-9-14(10-8-13)26(24,25)23-17-4-2-1-3-15(17)18-16(11-21-22-18)19(23)12-5-6-12/h1-4,7-12,19H,5-6H2,(H,21,22)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.170	n/a	n/a	n/a	n/a	n/a	n/a
Elan Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of Gamma-secretase in human IMR-32 cells after 2 hrs by ELISA assay				Bioorg Med Chem Lett 19: 4920-3 (2009) Article DOI: 10.1016/j.bmcl.2009.07.092 BindingDB Entry DOI: 10.7270/Q2DR2ZBR
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM50481056 (CHEMBL572032) Show SMILES FC(F)(F)c1ccc(cc1)S(=O)(=O)N1C(C2CC2)c2c[nH]nc2-c2ccc(cc12)C#N Show InChI InChI=1S/C21H15F3N4O2S/c22-21(23,24)14-4-6-15(7-5-14)31(29,30)28-18-9-12(10-25)1-8-16(18)19-17(11-26-27-19)20(28)13-2-3-13/h1,4-9,11,13,20H,2-3H2,(H,26,27)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.170	n/a	n/a	n/a	n/a	n/a	n/a
Elan Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of Gamma-secretase in human IMR-32 cells after 2 hrs by ELISA assay				Bioorg Med Chem Lett 19: 4920-3 (2009) Article DOI: 10.1016/j.bmcl.2009.07.092 BindingDB Entry DOI: 10.7270/Q2DR2ZBR
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM50481086 (CHEMBL571602) Show SMILES FC(F)(F)c1ccc(cc1)S(=O)(=O)N1C(C2CC2)c2c[nH]nc2-c2ccc(cc12)-c1cncnc1 Show InChI InChI=1S/C24H18F3N5O2S/c25-24(26,27)17-4-6-18(7-5-17)35(33,34)32-21-9-15(16-10-28-13-29-11-16)3-8-19(21)22-20(12-30-31-22)23(32)14-1-2-14/h3-14,23H,1-2H2,(H,30,31)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.200	n/a	n/a	n/a	n/a	n/a	n/a
Elan Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of Gamma-secretase in human IMR-32 cells after 2 hrs by ELISA assay				Bioorg Med Chem Lett 19: 4920-3 (2009) Article DOI: 10.1016/j.bmcl.2009.07.092 BindingDB Entry DOI: 10.7270/Q2DR2ZBR
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM50481087 (CHEMBL571145) Show SMILES FC(F)(F)C1N(c2ccccc2-c2n[nH]cc12)S(=O)(=O)c1ccc(Cl)cc1 Show InChI InChI=1S/C17H11ClF3N3O2S/c18-10-5-7-11(8-6-10)27(25,26)24-14-4-2-1-3-12(14)15-13(9-22-23-15)16(24)17(19,20)21/h1-9,16H,(H,22,23)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.210	n/a	n/a	n/a	n/a	n/a	n/a
Elan Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of Gamma-secretase in human IMR-32 cells after 2 hrs by ELISA assay				Bioorg Med Chem Lett 19: 4920-3 (2009) Article DOI: 10.1016/j.bmcl.2009.07.092 BindingDB Entry DOI: 10.7270/Q2DR2ZBR
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM50481063 (CHEMBL583662) Show SMILES FC(F)(F)c1ccc(cc1)S(=O)(=O)N1C(C2CC2)c2c[nH]nc2-c2ccc(cc12)-n1ccnc1 Show InChI InChI=1S/C23H18F3N5O2S/c24-23(25,26)15-3-6-17(7-4-15)34(32,33)31-20-11-16(30-10-9-27-13-30)5-8-18(20)21-19(12-28-29-21)22(31)14-1-2-14/h3-14,22H,1-2H2,(H,28,29)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.240	n/a	n/a	n/a	n/a	n/a	n/a
Elan Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of Gamma-secretase in human IMR-32 cells after 2 hrs by ELISA assay				Bioorg Med Chem Lett 19: 4920-3 (2009) Article DOI: 10.1016/j.bmcl.2009.07.092 BindingDB Entry DOI: 10.7270/Q2DR2ZBR
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM50481089 (CHEMBL584330) Show SMILES COC(=O)c1ccc2-c3n[nH]cc3C(C3CC3)N(c2c1)S(=O)(=O)c1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C22H18F3N3O4S/c1-32-21(29)13-4-9-16-18(10-13)28(20(12-2-3-12)17-11-26-27-19(16)17)33(30,31)15-7-5-14(6-8-15)22(23,24)25/h4-12,20H,2-3H2,1H3,(H,26,27)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.260	n/a	n/a	n/a	n/a	n/a	n/a
Elan Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of Gamma-secretase in human IMR-32 cells after 2 hrs by ELISA assay				Bioorg Med Chem Lett 19: 4920-3 (2009) Article DOI: 10.1016/j.bmcl.2009.07.092 BindingDB Entry DOI: 10.7270/Q2DR2ZBR
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM50481058 (CHEMBL570694) Show SMILES FC(F)(F)c1ccc(cc1)S(=O)(=O)N1C(C2CC2)c2c[nH]nc2-c2ccc(cc12)N1CCOC1=O Show InChI InChI=1S/C23H19F3N4O4S/c24-23(25,26)14-3-6-16(7-4-14)35(32,33)30-19-11-15(29-9-10-34-22(29)31)5-8-17(19)20-18(12-27-28-20)21(30)13-1-2-13/h3-8,11-13,21H,1-2,9-10H2,(H,27,28)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.260	n/a	n/a	n/a	n/a	n/a	n/a
Elan Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of Gamma-secretase in human IMR-32 cells after 2 hrs by ELISA assay				Bioorg Med Chem Lett 19: 4920-3 (2009) Article DOI: 10.1016/j.bmcl.2009.07.092 BindingDB Entry DOI: 10.7270/Q2DR2ZBR
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM50481055 (CHEMBL571821) Show SMILES FC(F)(F)c1ccc(cc1)S(=O)(=O)N1C(C2CC2)c2c[nH]nc2-c2ccc(I)cc12 Show InChI InChI=1S/C20H15F3IN3O2S/c21-20(22,23)12-3-6-14(7-4-12)30(28,29)27-17-9-13(24)5-8-15(17)18-16(10-25-26-18)19(27)11-1-2-11/h3-11,19H,1-2H2,(H,25,26)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.260	n/a	n/a	n/a	n/a	n/a	n/a
Elan Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of Gamma-secretase in human IMR-32 cells after 2 hrs by ELISA assay				Bioorg Med Chem Lett 19: 4920-3 (2009) Article DOI: 10.1016/j.bmcl.2009.07.092 BindingDB Entry DOI: 10.7270/Q2DR2ZBR
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM50481061 (CHEMBL570379) Show SMILES CC(C)C1N(c2ccccc2-c2n[nH]cc12)S(=O)(=O)c1ccc(Cl)cc1 Show InChI InChI=1S/C19H18ClN3O2S/c1-12(2)19-16-11-21-22-18(16)15-5-3-4-6-17(15)23(19)26(24,25)14-9-7-13(20)8-10-14/h3-12,19H,1-2H3,(H,21,22)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.280	n/a	n/a	n/a	n/a	n/a	n/a
Elan Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of Gamma-secretase in human IMR-32 cells after 2 hrs by ELISA assay				Bioorg Med Chem Lett 19: 4920-3 (2009) Article DOI: 10.1016/j.bmcl.2009.07.092 BindingDB Entry DOI: 10.7270/Q2DR2ZBR
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM50481081 (CHEMBL584956) Show SMILES FC(F)(F)c1ccc(cc1)S(=O)(=O)N1C(C2CC2)c2c[nH]nc2-c2ccccc12 Show InChI InChI=1S/C20H16F3N3O2S/c21-20(22,23)13-7-9-14(10-8-13)29(27,28)26-17-4-2-1-3-15(17)18-16(11-24-25-18)19(26)12-5-6-12/h1-4,7-12,19H,5-6H2,(H,24,25)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.310	n/a	n/a	n/a	n/a	n/a	n/a
Elan Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of Gamma-secretase in human IMR-32 cells after 2 hrs by ELISA assay				Bioorg Med Chem Lett 19: 4920-3 (2009) Article DOI: 10.1016/j.bmcl.2009.07.092 BindingDB Entry DOI: 10.7270/Q2DR2ZBR
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM50481070 (CHEMBL571591) Show SMILES CCC1N(c2ccccc2-c2n[nH]cc12)S(=O)(=O)c1ccc(Cl)cc1 Show InChI InChI=1S/C18H16ClN3O2S/c1-2-16-15-11-20-21-18(15)14-5-3-4-6-17(14)22(16)25(23,24)13-9-7-12(19)8-10-13/h3-11,16H,2H2,1H3,(H,20,21)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.360	n/a	n/a	n/a	n/a	n/a	n/a
Elan Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of Gamma-secretase in human IMR-32 cells after 2 hrs by ELISA assay				Bioorg Med Chem Lett 19: 4920-3 (2009) Article DOI: 10.1016/j.bmcl.2009.07.092 BindingDB Entry DOI: 10.7270/Q2DR2ZBR
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM50481068 (CHEMBL584113) Show SMILES Fc1ccc2N(C(C3CC3)c3c[nH]nc3-c2c1)S(=O)(=O)c1ccc(OC(F)(F)F)cc1 Show InChI InChI=1S/C20H15F4N3O3S/c21-12-3-8-17-15(9-12)18-16(10-25-26-18)19(11-1-2-11)27(17)31(28,29)14-6-4-13(5-7-14)30-20(22,23)24/h3-11,19H,1-2H2,(H,25,26)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.370	n/a	n/a	n/a	n/a	n/a	n/a
Elan Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of Gamma-secretase in human IMR-32 cells after 2 hrs by ELISA assay				Bioorg Med Chem Lett 19: 4920-3 (2009) Article DOI: 10.1016/j.bmcl.2009.07.092 BindingDB Entry DOI: 10.7270/Q2DR2ZBR
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM50481064 (CHEMBL585713) Show SMILES FC(F)(F)c1ccc(cc1)S(=O)(=O)N1C(C2CC2)c2c[nH]nc2-c2ccc(cc12)-c1cscn1 Show InChI InChI=1S/C23H17F3N4O2S2/c24-23(25,26)15-4-6-16(7-5-15)34(31,32)30-20-9-14(19-11-33-12-27-19)3-8-17(20)21-18(10-28-29-21)22(30)13-1-2-13/h3-13,22H,1-2H2,(H,28,29)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.410	n/a	n/a	n/a	n/a	n/a	n/a
Elan Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of Gamma-secretase in human IMR-32 cells after 2 hrs by ELISA assay				Bioorg Med Chem Lett 19: 4920-3 (2009) Article DOI: 10.1016/j.bmcl.2009.07.092 BindingDB Entry DOI: 10.7270/Q2DR2ZBR
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM50481043 (CHEMBL583660) Show SMILES Fc1ccc(cc1)S(=O)(=O)N1C(C2CC2)c2c[nH]nc2-c2ccccc12 Show InChI InChI=1S/C19H16FN3O2S/c20-13-7-9-14(10-8-13)26(24,25)23-17-4-2-1-3-15(17)18-16(11-21-22-18)19(23)12-5-6-12/h1-4,7-12,19H,5-6H2,(H,21,22)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.420	n/a	n/a	n/a	n/a	n/a	n/a
Elan Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of Gamma-secretase in human IMR-32 cells after 2 hrs by ELISA assay				Bioorg Med Chem Lett 19: 4920-3 (2009) Article DOI: 10.1016/j.bmcl.2009.07.092 BindingDB Entry DOI: 10.7270/Q2DR2ZBR
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM50481069 (CHEMBL571175) Show SMILES FC(F)(F)c1ccc(cc1)S(=O)(=O)N1C(C2CC2)c2c[nH]nc2-c2ccc(Cl)cc12 Show InChI InChI=1S/C20H15ClF3N3O2S/c21-13-5-8-15-17(9-13)27(19(11-1-2-11)16-10-25-26-18(15)16)30(28,29)14-6-3-12(4-7-14)20(22,23)24/h3-11,19H,1-2H2,(H,25,26)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.440	n/a	n/a	n/a	n/a	n/a	n/a
Elan Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of Gamma-secretase in human IMR-32 cells after 2 hrs by ELISA assay				Bioorg Med Chem Lett 19: 4920-3 (2009) Article DOI: 10.1016/j.bmcl.2009.07.092 BindingDB Entry DOI: 10.7270/Q2DR2ZBR
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM50481075 (CHEMBL571817) Show SMILES Fc1cc2N(C(C3CC3)c3c[nH]nc3-c2cc1F)S(=O)(=O)c1ncc(Cl)s1 Show InChI InChI=1S/C16H11ClF2N4O2S2/c17-13-6-20-16(26-13)27(24,25)23-12-4-11(19)10(18)3-8(12)14-9(5-21-22-14)15(23)7-1-2-7/h3-7,15H,1-2H2,(H,21,22)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.460	n/a	n/a	n/a	n/a	n/a	n/a
Elan Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of Gamma-secretase in human IMR-32 cells after 2 hrs by ELISA assay				Bioorg Med Chem Lett 19: 4920-3 (2009) Article DOI: 10.1016/j.bmcl.2009.07.092 BindingDB Entry DOI: 10.7270/Q2DR2ZBR
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM50482032 (ENT A) Show SMILES CC[C@H]1Cc2n[nH]cc2[C@@H](CC)N1S(=O)(=O)c1ccc(Cl)cc1 |r| Show InChI InChI=1S/C16H20ClN3O2S/c1-3-12-9-15-14(10-18-19-15)16(4-2)20(12)23(21,22)13-7-5-11(17)6-8-13/h5-8,10,12,16H,3-4,9H2,1-2H3,(H,18,19)/t12-,16+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.480	n/a	n/a	n/a	n/a	n/a	n/a
Elan Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of gamma-secretase-mediated APP cleavage in human IMR-32 cells assessed as amyloid beta40 level after 2 hrs by ELISA				Bioorg Med Chem Lett 20: 2195-9 (2010) Article DOI: 10.1016/j.bmcl.2010.02.039 BindingDB Entry DOI: 10.7270/Q2RN3BP7
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM50482032 (ENT A) Show SMILES CC[C@H]1Cc2n[nH]cc2[C@@H](CC)N1S(=O)(=O)c1ccc(Cl)cc1 |r| Show InChI InChI=1S/C16H20ClN3O2S/c1-3-12-9-15-14(10-18-19-15)16(4-2)20(12)23(21,22)13-7-5-11(17)6-8-13/h5-8,10,12,16H,3-4,9H2,1-2H3,(H,18,19)/t12-,16+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.480	n/a	n/a	n/a	n/a	n/a	n/a
Elan Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of gamma-secretase-mediated APP cleavage in human IMR-32 cells assessed as amyloid beta40 level after 2 hrs by ELISA				Bioorg Med Chem Lett 20: 2195-9 (2010) Article DOI: 10.1016/j.bmcl.2010.02.039 BindingDB Entry DOI: 10.7270/Q2RN3BP7
					More data for this Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM282619 (US9884828, 2-114) Show SMILES CN(C)C(=O)c1ccc(cc1)-c1ccc2cc(nnc2c1)C(N)=O Show InChI InChI=1S/C18H16N4O2/c1-22(2)18(24)12-5-3-11(4-6-12)13-7-8-14-10-16(17(19)23)21-20-15(14)9-13/h3-10H,1-2H3,(H2,19,23)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	7.5	25
Imago Pharmaceuticals, Inc. US Patent					Assay Description Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...				US Patent US9884828 (2018) BindingDB Entry DOI: 10.7270/Q2NG4SNW
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM50481154 (CHEMBL570980) Show SMILES CC#CC1CC2Cc3[nH]ncc3C(C1)N2S(=O)(=O)c1ccc(Cl)cc1 |TLB:2:3:14:6.11.7,THB:10:11:4.3.13:14| Show InChI InChI=1S/C18H18ClN3O2S/c1-2-3-12-8-14-10-17-16(11-20-21-17)18(9-12)22(14)25(23,24)15-6-4-13(19)5-7-15/h4-7,11-12,14,18H,8-10H2,1H3,(H,20,21)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.520	n/a	n/a	n/a	n/a	n/a	n/a
Elan Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of gamma secretase in human IMR32 cells assessed as inhibition of Abeta40 site cleavage by ELISA				Bioorg Med Chem Lett 19: 6952-6 (2009) Article DOI: 10.1016/j.bmcl.2009.10.060 BindingDB Entry DOI: 10.7270/Q2N87DKH
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM50481048 (CHEMBL584115) Show SMILES Fc1cc2N(C(C3CC3)c3c[nH]nc3-c2cc1F)S(=O)(=O)c1ccc(Cl)s1 Show InChI InChI=1S/C17H12ClF2N3O2S2/c18-14-3-4-15(26-14)27(24,25)23-13-6-12(20)11(19)5-9(13)16-10(7-21-22-16)17(23)8-1-2-8/h3-8,17H,1-2H2,(H,21,22)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.520	n/a	n/a	n/a	n/a	n/a	n/a
Elan Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of Gamma-secretase in human IMR-32 cells after 2 hrs by ELISA assay				Bioorg Med Chem Lett 19: 4920-3 (2009) Article DOI: 10.1016/j.bmcl.2009.07.092 BindingDB Entry DOI: 10.7270/Q2DR2ZBR
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM50481088 (CHEMBL568891) Show SMILES FC(F)(F)c1ccc(cc1)S(=O)(=O)N1C(C2CC2)c2c[nH]nc2-c2ccc(cc12)N1CCOCC1 Show InChI InChI=1S/C24H23F3N4O3S/c25-24(26,27)16-3-6-18(7-4-16)35(32,33)31-21-13-17(30-9-11-34-12-10-30)5-8-19(21)22-20(14-28-29-22)23(31)15-1-2-15/h3-8,13-15,23H,1-2,9-12H2,(H,28,29)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.580	n/a	n/a	n/a	n/a	n/a	n/a
Elan Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of Gamma-secretase in human IMR-32 cells after 2 hrs by ELISA assay				Bioorg Med Chem Lett 19: 4920-3 (2009) Article DOI: 10.1016/j.bmcl.2009.07.092 BindingDB Entry DOI: 10.7270/Q2DR2ZBR
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM50481065 (CHEMBL571818) Show SMILES C[C@H]1N(c2ccc(F)cc2-c2n[nH]cc12)S(=O)(=O)c1ccc(Cl)cc1 |r| Show InChI InChI=1S/C17H13ClFN3O2S/c1-10-15-9-20-21-17(15)14-8-12(19)4-7-16(14)22(10)25(23,24)13-5-2-11(18)3-6-13/h2-10H,1H3,(H,20,21)/t10-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.620	n/a	n/a	n/a	n/a	n/a	n/a
Elan Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of Gamma-secretase in human IMR-32 cells after 2 hrs by ELISA assay				Bioorg Med Chem Lett 19: 4920-3 (2009) Article DOI: 10.1016/j.bmcl.2009.07.092 BindingDB Entry DOI: 10.7270/Q2DR2ZBR
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM50481054 (CHEMBL583674) Show SMILES CC1N(c2cc(O)ccc2-c2n[nH]cc12)S(=O)(=O)c1ccc(Cl)cc1 Show InChI InChI=1S/C17H14ClN3O3S/c1-10-15-9-19-20-17(15)14-7-4-12(22)8-16(14)21(10)25(23,24)13-5-2-11(18)3-6-13/h2-10,22H,1H3,(H,19,20)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.650	n/a	n/a	n/a	n/a	n/a	n/a
Elan Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of Gamma-secretase in human IMR-32 cells after 2 hrs by ELISA assay				Bioorg Med Chem Lett 19: 4920-3 (2009) Article DOI: 10.1016/j.bmcl.2009.07.092 BindingDB Entry DOI: 10.7270/Q2DR2ZBR
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM50481079 (CHEMBL585538) Show SMILES Fc1ccc2N([C@H](C3CC3)c3c[nH]nc3-c2c1)S(=O)(=O)c1ccc(cn1)C(F)(F)F |r| Show InChI InChI=1S/C19H14F4N4O2S/c20-12-4-5-15-13(7-12)17-14(9-25-26-17)18(10-1-2-10)27(15)30(28,29)16-6-3-11(8-24-16)19(21,22)23/h3-10,18H,1-2H2,(H,25,26)/t18-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.670	n/a	n/a	n/a	n/a	n/a	n/a
Elan Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of Gamma-secretase in human IMR-32 cells after 2 hrs by ELISA assay				Bioorg Med Chem Lett 19: 4920-3 (2009) Article DOI: 10.1016/j.bmcl.2009.07.092 BindingDB Entry DOI: 10.7270/Q2DR2ZBR
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM50481067 (CHEMBL571387) Show SMILES O=S(=O)(N1C(C2CC2)c2c[nH]nc2-c2ccccc12)c1ccc(cc1)C#N Show InChI InChI=1S/C20H16N4O2S/c21-11-13-5-9-15(10-6-13)27(25,26)24-18-4-2-1-3-16(18)19-17(12-22-23-19)20(24)14-7-8-14/h1-6,9-10,12,14,20H,7-8H2,(H,22,23)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.740	n/a	n/a	n/a	n/a	n/a	n/a
Elan Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of Gamma-secretase in human IMR-32 cells after 2 hrs by ELISA assay				Bioorg Med Chem Lett 19: 4920-3 (2009) Article DOI: 10.1016/j.bmcl.2009.07.092 BindingDB Entry DOI: 10.7270/Q2DR2ZBR
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM50481148 (CHEMBL570752) Show SMILES Clc1ccc(cc1)S(=O)(=O)N1C2CC(CC1c1cn[nH]c1C2)C#C |TLB:17:16:12.13.14:10,THB:22:13:10:21.16.20| Show InChI InChI=1S/C17H16ClN3O2S/c1-2-11-7-13-9-16-15(10-19-20-16)17(8-11)21(13)24(22,23)14-5-3-12(18)4-6-14/h1,3-6,10-11,13,17H,7-9H2,(H,19,20)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.75	n/a	n/a	n/a	n/a	n/a	n/a
Elan Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of gamma secretase in human IMR32 cells assessed as inhibition of Abeta40 site cleavage by ELISA				Bioorg Med Chem Lett 19: 6952-6 (2009) Article DOI: 10.1016/j.bmcl.2009.10.060 BindingDB Entry DOI: 10.7270/Q2N87DKH
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM50481045 (CHEMBL569570) Show SMILES FC(F)Oc1ccc(cc1)S(=O)(=O)N1C(C2CC2)c2c[nH]nc2-c2cc(F)ccc12 Show InChI InChI=1S/C20H16F3N3O3S/c21-12-3-8-17-15(9-12)18-16(10-24-25-18)19(11-1-2-11)26(17)30(27,28)14-6-4-13(5-7-14)29-20(22)23/h3-11,19-20H,1-2H2,(H,24,25)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.760	n/a	n/a	n/a	n/a	n/a	n/a
Elan Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of Gamma-secretase in human IMR-32 cells after 2 hrs by ELISA assay				Bioorg Med Chem Lett 19: 4920-3 (2009) Article DOI: 10.1016/j.bmcl.2009.07.092 BindingDB Entry DOI: 10.7270/Q2DR2ZBR
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM50482033 (CHEMBL1093761) Show SMILES CC(C)[C@H]1Cc2n[nH]cc2[C@@H](C(C)C)N1S(=O)(=O)c1ccc(cc1)C(F)(F)F |r| Show InChI InChI=1S/C19H24F3N3O2S/c1-11(2)17-9-16-15(10-23-24-16)18(12(3)4)25(17)28(26,27)14-7-5-13(6-8-14)19(20,21)22/h5-8,10-12,17-18H,9H2,1-4H3,(H,23,24)/t17-,18-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.770	n/a	n/a	n/a	n/a	n/a	n/a
Elan Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of gamma-secretase-mediated APP cleavage in human IMR-32 cells assessed as amyloid beta40 level after 2 hrs by ELISA				Bioorg Med Chem Lett 20: 2195-9 (2010) Article DOI: 10.1016/j.bmcl.2010.02.039 BindingDB Entry DOI: 10.7270/Q2RN3BP7
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM50481057 (CHEMBL571822) Show SMILES CC1N(c2cc(OC(=O)N(C)C)ccc2-c2n[nH]cc12)S(=O)(=O)c1ccc(Cl)cc1 Show InChI InChI=1S/C20H19ClN4O4S/c1-12-17-11-22-23-19(17)16-9-6-14(29-20(26)24(2)3)10-18(16)25(12)30(27,28)15-7-4-13(21)5-8-15/h4-12H,1-3H3,(H,22,23)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.930	n/a	n/a	n/a	n/a	n/a	n/a
Elan Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of Gamma-secretase in human IMR-32 cells after 2 hrs by ELISA assay				Bioorg Med Chem Lett 19: 4920-3 (2009) Article DOI: 10.1016/j.bmcl.2009.07.092 BindingDB Entry DOI: 10.7270/Q2DR2ZBR
					More data for this Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM282606 (US9884828, 2-101) Show SMILES C[C@@H](Nc1c(nnc2cc(ccc12)-c1cnn(C)c1)C(N)=O)C1CC1 Show InChI InChI=1S/C18H20N6O/c1-10(11-3-4-11)21-16-14-6-5-12(13-8-20-24(2)9-13)7-15(14)22-23-17(16)18(19)25/h5-11H,3-4H2,1-2H3,(H2,19,25)(H,21,22)/t10-/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	7.5	25
Imago Pharmaceuticals, Inc. US Patent					Assay Description Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...				US Patent US9884828 (2018) BindingDB Entry DOI: 10.7270/Q2NG4SNW
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 8 (Homo sapiens (Human))	BDBM50352621 (CHEMBL1822152) Show SMILES Brc1csc(NC(=O)Cn2c3cc(ccc3ccc2=O)C#N)c1-c1nnc[nH]1 Show InChI InChI=1S/C18H11BrN6O2S/c19-12-8-28-18(16(12)17-21-9-22-24-17)23-14(26)7-25-13-5-10(6-20)1-2-11(13)3-4-15(25)27/h1-5,8-9H,7H2,(H,23,26)(H,21,22,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Elan Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of recombinant JNK1 using ser73 of c-jun as substrate preincubated for 15 mins measured after 60 mins by TR-FRET assay				Bioorg Med Chem Lett 21: 5521-7 (2011) Article DOI: 10.1016/j.bmcl.2011.06.100 BindingDB Entry DOI: 10.7270/Q29Z959K
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 8 (Homo sapiens (Human))	BDBM50352620 (CHEMBL1822151) Show SMILES Brc1csc(NC(=O)Cn2c3ccc(cc3ccc2=O)C#N)c1-c1nnc[nH]1 Show InChI InChI=1S/C18H11BrN6O2S/c19-12-8-28-18(16(12)17-21-9-22-24-17)23-14(26)7-25-13-3-1-10(6-20)5-11(13)2-4-15(25)27/h1-5,8-9H,7H2,(H,23,26)(H,21,22,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Elan Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of recombinant JNK1 using ser73 of c-jun as substrate preincubated for 15 mins measured after 60 mins by TR-FRET assay				Bioorg Med Chem Lett 21: 5521-7 (2011) Article DOI: 10.1016/j.bmcl.2011.06.100 BindingDB Entry DOI: 10.7270/Q29Z959K
					More data for this Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM50428717 (CHEMBL2333127 | US9884828, 2-37) Show SMILES CC[C@@H](C)Nc1c(nnc2cc(ccc12)-c1ccc(cc1)S(C)(=O)=O)C(N)=O |r| Show InChI InChI=1S/C20H22N4O3S/c1-4-12(2)22-18-16-10-7-14(11-17(16)23-24-19(18)20(21)25)13-5-8-15(9-6-13)28(3,26)27/h5-12H,4H2,1-3H3,(H2,21,25)(H,22,23)/t12-/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Elan Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of wild type GST-tagged LRRK2 (970 to 2527 amino acid residues) (unknown origin) assessed as inhibition of biotinylated-LRRKtide phosphory...				Bioorg Med Chem Lett 23: 71-4 (2012) Article DOI: 10.1016/j.bmcl.2012.11.021 BindingDB Entry DOI: 10.7270/Q2930VHH
					More data for this Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM50428716 (CHEMBL2333128 | US9884828, 2-41) Show SMILES C[C@@H](Nc1c(nnc2cc(ccc12)-c1ccc(cc1)S(C)(=O)=O)C(N)=O)C1CC1 |r| Show InChI InChI=1S/C21H22N4O3S/c1-12(13-3-4-13)23-19-17-10-7-15(11-18(17)24-25-20(19)21(22)26)14-5-8-16(9-6-14)29(2,27)28/h5-13H,3-4H2,1-2H3,(H2,22,26)(H,23,24)/t12-/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Elan Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of wild type GST-tagged LRRK2 (970 to 2527 amino acid residues) (unknown origin) assessed as inhibition of biotinylated-LRRKtide phosphory...				Bioorg Med Chem Lett 23: 71-4 (2012) Article DOI: 10.1016/j.bmcl.2012.11.021 BindingDB Entry DOI: 10.7270/Q2930VHH
					More data for this Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM50428701 (CHEMBL2333115 | US9884828, 2-127) Show SMILES CC(C)Nc1c(nnc2ccc(cc12)-c1cn[nH]c1)C(N)=O Show InChI InChI=1S/C15H16N6O/c1-8(2)19-13-11-5-9(10-6-17-18-7-10)3-4-12(11)20-21-14(13)15(16)22/h3-8H,1-2H3,(H2,16,22)(H,17,18)(H,19,20)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Elan Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of wild type GST-tagged LRRK2 (970 to 2527 amino acid residues) (unknown origin) assessed as inhibition of biotinylated-LRRKtide phosphory...				Bioorg Med Chem Lett 23: 71-4 (2012) Article DOI: 10.1016/j.bmcl.2012.11.021 BindingDB Entry DOI: 10.7270/Q2930VHH
					More data for this Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM282670 (US9884828, 9-213) Show SMILES C[C@@H](Nc1c(nnc2cc(ccc12)-c1ccc(cc1)N1CCOC1=O)C(N)=O)C1CC1 Show InChI InChI=1S/C23H23N5O3/c1-13(14-2-3-14)25-20-18-9-6-16(12-19(18)26-27-21(20)22(24)29)15-4-7-17(8-5-15)28-10-11-31-23(28)30/h4-9,12-14H,2-3,10-11H2,1H3,(H2,24,29)(H,25,26)/t13-/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	7.5	25
Imago Pharmaceuticals, Inc. US Patent					Assay Description Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...				US Patent US9884828 (2018) BindingDB Entry DOI: 10.7270/Q2NG4SNW
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM50481147 (CHEMBL585542) Show SMILES Cl\C=C\C1CC2Cc3[nH]ncc3C(C1)N2S(=O)(=O)c1ccc(Cl)cc1 |TLB:2:3:14:6.11.7,THB:10:11:4.3.13:14| Show InChI InChI=1S/C17H17Cl2N3O2S/c18-6-5-11-7-13-9-16-15(10-20-21-16)17(8-11)22(13)25(23,24)14-3-1-12(19)2-4-14/h1-6,10-11,13,17H,7-9H2,(H,20,21)/b6-5+	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Elan Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of gamma secretase in human IMR32 cells assessed as inhibition of Abeta40 site cleavage by ELISA				Bioorg Med Chem Lett 19: 6952-6 (2009) Article DOI: 10.1016/j.bmcl.2009.10.060 BindingDB Entry DOI: 10.7270/Q2N87DKH
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM50481164 (CHEMBL585911) Show SMILES FC(F)(F)\C=C\C1CC2Cc3[nH]ncc3C(C1)N2S(=O)(=O)c1ccc(Cl)cc1 |TLB:5:6:17:9.14.10,THB:13:14:7.6.16:17| Show InChI InChI=1S/C18H17ClF3N3O2S/c19-12-1-3-14(4-2-12)28(26,27)25-13-7-11(5-6-18(20,21)22)8-17(25)15-10-23-24-16(15)9-13/h1-6,10-11,13,17H,7-9H2,(H,23,24)/b6-5+	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Elan Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of gamma secretase in human IMR32 cells assessed as inhibition of Abeta40 site cleavage by ELISA				Bioorg Med Chem Lett 19: 6952-6 (2009) Article DOI: 10.1016/j.bmcl.2009.10.060 BindingDB Entry DOI: 10.7270/Q2N87DKH
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM50482050 (CHEMBL1090408) Show SMILES CC[C@H]1Cc2n[nH]cc2CN1S(=O)(=O)c1ccc(Cl)cc1 |r| Show InChI InChI=1S/C14H16ClN3O2S/c1-2-12-7-14-10(8-16-17-14)9-18(12)21(19,20)13-5-3-11(15)4-6-13/h3-6,8,12H,2,7,9H2,1H3,(H,16,17)/t12-/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Elan Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of gamma-secretase-mediated APP cleavage in human IMR-32 cells assessed as amyloid beta40 level after 2 hrs by ELISA				Bioorg Med Chem Lett 20: 2195-9 (2010) Article DOI: 10.1016/j.bmcl.2010.02.039 BindingDB Entry DOI: 10.7270/Q2RN3BP7
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 8 (Homo sapiens (Human))	BDBM50352624 (CHEMBL1822305 | US9796706, Compound 139) Show SMILES Cn1cnc(n1)-c1c(Br)csc1NC(=O)CN1C(=O)CCc2ncccc12 Show InChI InChI=1S/C17H15BrN6O2S/c1-23-9-20-16(22-23)15-10(18)8-27-17(15)21-13(25)7-24-12-3-2-6-19-11(12)4-5-14(24)26/h2-3,6,8-9H,4-5,7H2,1H3,(H,21,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Elan Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of recombinant JNK1 using ser73 of c-jun as substrate preincubated for 15 mins measured after 60 mins by TR-FRET assay				Bioorg Med Chem Lett 21: 5521-7 (2011) Article DOI: 10.1016/j.bmcl.2011.06.100 BindingDB Entry DOI: 10.7270/Q29Z959K
					More data for this Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM282616 (US9884828, 2-111) Show SMILES C[C@@H](Nc1c(nnc2cc(ccc12)-c1cccc(c1)S(C)(=O)=O)C(N)=O)C1CC1 Show InChI InChI=1S/C21H22N4O3S/c1-12(13-6-7-13)23-19-17-9-8-15(11-18(17)24-25-20(19)21(22)26)14-4-3-5-16(10-14)29(2,27)28/h3-5,8-13H,6-7H2,1-2H3,(H2,22,26)(H,23,24)/t12-/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	7.5	25
Imago Pharmaceuticals, Inc. US Patent					Assay Description Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...				US Patent US9884828 (2018) BindingDB Entry DOI: 10.7270/Q2NG4SNW
					More data for this Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM282625 (US9884828, 2-120) Show SMILES C[C@@H](Nc1c(nnc2cc(ccc12)-c1ccc2CC(=O)Nc2c1)C(N)=O)C1CC1 Show InChI InChI=1S/C22H21N5O2/c1-11(12-2-3-12)24-20-16-7-6-14(9-18(16)26-27-21(20)22(23)29)13-4-5-15-10-19(28)25-17(15)8-13/h4-9,11-12H,2-3,10H2,1H3,(H2,23,29)(H,24,26)(H,25,28)/t11-/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	7.5	25
Imago Pharmaceuticals, Inc. US Patent					Assay Description Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...				US Patent US9884828 (2018) BindingDB Entry DOI: 10.7270/Q2NG4SNW
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM50481084 (CHEMBL570471) Show SMILES FC(F)(F)c1ccc(cc1)S(=O)(=O)N1C(C2CC2)c2c[nH]nc2-c2cccnc12 Show InChI InChI=1S/C19H15F3N4O2S/c20-19(21,22)12-5-7-13(8-6-12)29(27,28)26-17(11-3-4-11)15-10-24-25-16(15)14-2-1-9-23-18(14)26/h1-2,5-11,17H,3-4H2,(H,24,25)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a	n/a
Elan Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of Gamma-secretase in human IMR-32 cells after 2 hrs by ELISA assay				Bioorg Med Chem Lett 19: 4920-3 (2009) Article DOI: 10.1016/j.bmcl.2009.07.092 BindingDB Entry DOI: 10.7270/Q2DR2ZBR
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM50481060 (CHEMBL571590) Show SMILES CC1N(c2ccccc2-c2n[nH]cc12)S(=O)(=O)c1ccc(Cl)cc1 Show InChI InChI=1S/C17H14ClN3O2S/c1-11-15-10-19-20-17(15)14-4-2-3-5-16(14)21(11)24(22,23)13-8-6-12(18)7-9-13/h2-11H,1H3,(H,19,20)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.20	n/a	n/a	n/a	n/a	n/a	n/a
Elan Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of Gamma-secretase in human IMR-32 cells after 2 hrs by ELISA assay				Bioorg Med Chem Lett 19: 4920-3 (2009) Article DOI: 10.1016/j.bmcl.2009.07.092 BindingDB Entry DOI: 10.7270/Q2DR2ZBR
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM50481083 (CHEMBL584536) Show SMILES Fc1ccc2N(C(C3CC3)c3c[nH]nc3-c2c1)S(=O)(=O)c1ccc(Cl)cn1 Show InChI InChI=1S/C18H14ClFN4O2S/c19-11-3-6-16(21-8-11)27(25,26)24-15-5-4-12(20)7-13(15)17-14(9-22-23-17)18(24)10-1-2-10/h3-10,18H,1-2H2,(H,22,23)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.30	n/a	n/a	n/a	n/a	n/a	n/a
Elan Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of Gamma-secretase in human IMR-32 cells after 2 hrs by ELISA assay				Bioorg Med Chem Lett 19: 4920-3 (2009) Article DOI: 10.1016/j.bmcl.2009.07.092 BindingDB Entry DOI: 10.7270/Q2DR2ZBR
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM50481082 (CHEMBL571173) Show SMILES CC1N(c2cccc(F)c2-c2n[nH]cc12)S(=O)(=O)c1ccc(Cl)cc1 Show InChI InChI=1S/C17H13ClFN3O2S/c1-10-13-9-20-21-17(13)16-14(19)3-2-4-15(16)22(10)25(23,24)12-7-5-11(18)6-8-12/h2-10H,1H3,(H,20,21)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.40	n/a	n/a	n/a	n/a	n/a	n/a
Elan Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of Gamma-secretase in human IMR-32 cells after 2 hrs by ELISA assay				Bioorg Med Chem Lett 19: 4920-3 (2009) Article DOI: 10.1016/j.bmcl.2009.07.092 BindingDB Entry DOI: 10.7270/Q2DR2ZBR
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM50481078 (CHEMBL572033) Show SMILES CC1N(c2cc(OCc3ccccc3)ccc2-c2n[nH]cc12)S(=O)(=O)c1ccc(Cl)cc1 Show InChI InChI=1S/C24H20ClN3O3S/c1-16-22-14-26-27-24(22)21-12-9-19(31-15-17-5-3-2-4-6-17)13-23(21)28(16)32(29,30)20-10-7-18(25)8-11-20/h2-14,16H,15H2,1H3,(H,26,27)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.5	n/a	n/a	n/a	n/a	n/a	n/a
Elan Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of Gamma-secretase in human IMR-32 cells after 2 hrs by ELISA assay				Bioorg Med Chem Lett 19: 4920-3 (2009) Article DOI: 10.1016/j.bmcl.2009.07.092 BindingDB Entry DOI: 10.7270/Q2DR2ZBR
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM50481071 (CHEMBL571172) Show SMILES CC1N(c2ccc(F)cc2-c2n[nH]cc12)S(=O)(=O)c1ccc(Cl)cc1 Show InChI InChI=1S/C17H13ClFN3O2S/c1-10-15-9-20-21-17(15)14-8-12(19)4-7-16(14)22(10)25(23,24)13-5-2-11(18)3-6-13/h2-10H,1H3,(H,20,21)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.60	n/a	n/a	n/a	n/a	n/a	n/a
Elan Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of Gamma-secretase in human IMR-32 cells after 2 hrs by ELISA assay				Bioorg Med Chem Lett 19: 4920-3 (2009) Article DOI: 10.1016/j.bmcl.2009.07.092 BindingDB Entry DOI: 10.7270/Q2DR2ZBR
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 10 (Homo sapiens (Human))	BDBM16016 (CHEMBL437747 | N-cyclohexyl-4-[4-(3,4-dichlorophen...) Show SMILES CCCn1c(nc(c1-c1ccnc(NC2CCCCC2)n1)-c1ccc(Cl)c(Cl)c1)C1CCNCC1 Show InChI InChI=1S/C27H34Cl2N6/c1-2-16-35-25(23-12-15-31-27(33-23)32-20-6-4-3-5-7-20)24(19-8-9-21(28)22(29)17-19)34-26(35)18-10-13-30-14-11-18/h8-9,12,15,17-18,20,30H,2-7,10-11,13-14,16H2,1H3,(H,31,32,33)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank MMDB PDB Article PubMed	n/a	n/a	1.60	n/a	n/a	n/a	n/a	n/a	n/a
Elan Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of recombinant JNK3 after 60 mins by TR-FRET assay				Bioorg Med Chem Lett 21: 315-9 (2010) Article DOI: 10.1016/j.bmcl.2010.11.010 BindingDB Entry DOI: 10.7270/Q24F1R0T
					More data for this Ligand-Target Pair				3D Structure (crystal)

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