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Compile Data Set for Download or QSAR

Found 121 hits with Last Name = 'tsuchida' and Initial = 'h'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Solute carrier family 22 member 16


(Homo sapiens (Human))		BDBM50037268
PNG
((-)-Carnitine | (-)-L-Carnitine | (3R)-3-hydroxy-4...)
Show SMILES C[N+](C)(C)C[C@H](O)CC([O-])=O |r|
Show InChI InChI=1S/C7H15NO3/c1-8(2,3)5-6(9)4-7(10)11/h6,9H,4-5H2,1-3H3/t6-/m1/s1
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 3.00E+4n/an/an/an/an/an/an/an/a



Kyorin University

Curated by ChEMBL


Assay Description
TP_TRANSPORTER: inhibition of carnitine in Xenopus laevis oocytes

J Biol Chem 277: 36262-71 (2002)


Article DOI: 10.1074/jbc.M203883200
BindingDB Entry DOI: 10.7270/Q20003CS
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM50495787
PNG
(CHEMBL3114956)
Show SMILES COc1ccc(cc1Cl)-c1nc2CCCS(=O)(=O)c2c(Nc2ccc(CC(O)=O)c(F)c2)n1
Show InChI InChI=1S/C22H19ClFN3O5S/c1-32-18-7-5-13(9-15(18)23)21-26-17-3-2-8-33(30,31)20(17)22(27-21)25-14-6-4-12(10-19(28)29)16(24)11-14/h4-7,9,11H,2-3,8,10H2,1H3,(H,28,29)(H,25,26,27)
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n/an/a 3n/an/an/an/an/an/a



Kyushu University

Curated by ChEMBL


Assay Description
Inhibition of full-length human PDE4B2 assessed as cAMP hydrolysis preincubated for 20 mins followed by cAMP addition measured after 30 mins

Bioorg Med Chem Lett 24: 893-9 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.076
BindingDB Entry DOI: 10.7270/Q2GX4FHW
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM50495791
PNG
(CHEMBL3114958)
Show SMILES OC(=O)Cc1ccc(Nc2nc(nc3CCCS(=O)(=O)c23)-c2cc3ccccc3s2)cc1F
Show InChI InChI=1S/C23H18FN3O4S2/c24-16-12-15(8-7-13(16)11-20(28)29)25-23-21-17(5-3-9-33(21,30)31)26-22(27-23)19-10-14-4-1-2-6-18(14)32-19/h1-2,4,6-8,10,12H,3,5,9,11H2,(H,28,29)(H,25,26,27)
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n/an/a 3.80n/an/an/an/an/an/a



Kyushu University

Curated by ChEMBL


Assay Description
Inhibition of full-length human PDE4B2 assessed as cAMP hydrolysis preincubated for 20 mins followed by cAMP addition measured after 30 mins

Bioorg Med Chem Lett 24: 893-9 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.076
BindingDB Entry DOI: 10.7270/Q2GX4FHW
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM50495777
PNG
(CHEMBL3114948)
Show SMILES COc1ccc(cc1F)-c1nc2CCCS(=O)(=O)c2c(Nc2ccc(CC(O)=O)c(F)c2)n1
Show InChI InChI=1S/C22H19F2N3O5S/c1-32-18-7-5-13(9-16(18)24)21-26-17-3-2-8-33(30,31)20(17)22(27-21)25-14-6-4-12(10-19(28)29)15(23)11-14/h4-7,9,11H,2-3,8,10H2,1H3,(H,28,29)(H,25,26,27)
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n/an/a 4.60n/an/an/an/an/an/a



Kyushu University

Curated by ChEMBL


Assay Description
Inhibition of full-length human PDE4B2 assessed as cAMP hydrolysis preincubated for 20 mins followed by cAMP addition measured after 30 mins

Bioorg Med Chem Lett 24: 893-9 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.076
BindingDB Entry DOI: 10.7270/Q2GX4FHW
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM50495793
PNG
(CHEMBL3114950)
Show SMILES COc1ccc(cc1F)-c1nc2CCCS(=O)(=O)c2c(Nc2cc(F)c(CC(O)=O)c(F)c2)n1
Show InChI InChI=1S/C22H18F3N3O5S/c1-33-18-5-4-11(7-16(18)25)21-27-17-3-2-6-34(31,32)20(17)22(28-21)26-12-8-14(23)13(10-19(29)30)15(24)9-12/h4-5,7-9H,2-3,6,10H2,1H3,(H,29,30)(H,26,27,28)
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n/an/a 5.20n/an/an/an/an/an/a



Kyushu University

Curated by ChEMBL


Assay Description
Inhibition of full-length human PDE4B2 assessed as cAMP hydrolysis preincubated for 20 mins followed by cAMP addition measured after 30 mins

Bioorg Med Chem Lett 24: 893-9 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.076
BindingDB Entry DOI: 10.7270/Q2GX4FHW
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM50495778
PNG
(CHEMBL3114957)
Show SMILES OC(=O)Cc1ccc(Nc2nc(nc3CCCS(=O)(=O)c23)-c2ccc3ccccc3c2)cc1F
Show InChI InChI=1S/C25H20FN3O4S/c26-20-14-19(10-9-17(20)13-22(30)31)27-25-23-21(6-3-11-34(23,32)33)28-24(29-25)18-8-7-15-4-1-2-5-16(15)12-18/h1-2,4-5,7-10,12,14H,3,6,11,13H2,(H,30,31)(H,27,28,29)
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n/an/a 5.90n/an/an/an/an/an/a



Kyushu University

Curated by ChEMBL


Assay Description
Inhibition of full-length human PDE4B2 assessed as cAMP hydrolysis preincubated for 20 mins followed by cAMP addition measured after 30 mins

Bioorg Med Chem Lett 24: 893-9 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.076
BindingDB Entry DOI: 10.7270/Q2GX4FHW
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM50495788
PNG
(CHEMBL3114954)
Show SMILES COc1ccc(cc1)-c1nc2CCCS(=O)(=O)c2c(Nc2ccc(CC(O)=O)c(F)c2)n1
Show InChI InChI=1S/C22H20FN3O5S/c1-31-16-8-5-13(6-9-16)21-25-18-3-2-10-32(29,30)20(18)22(26-21)24-15-7-4-14(11-19(27)28)17(23)12-15/h4-9,12H,2-3,10-11H2,1H3,(H,27,28)(H,24,25,26)
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n/an/a 7.5n/an/an/an/an/an/a



Kyushu University

Curated by ChEMBL


Assay Description
Inhibition of full-length human PDE4B2 assessed as cAMP hydrolysis preincubated for 20 mins followed by cAMP addition measured after 30 mins

Bioorg Med Chem Lett 24: 893-9 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.076
BindingDB Entry DOI: 10.7270/Q2GX4FHW
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM50495755
PNG
(CHEMBL3114955)
Show SMILES COc1ccc(c(F)c1F)-c1nc2CCCS(=O)(=O)c2c(Nc2ccc(CC(O)=O)c(F)c2)n1
Show InChI InChI=1S/C22H18F3N3O5S/c1-33-16-7-6-13(18(24)19(16)25)21-27-15-3-2-8-34(31,32)20(15)22(28-21)26-12-5-4-11(9-17(29)30)14(23)10-12/h4-7,10H,2-3,8-9H2,1H3,(H,29,30)(H,26,27,28)
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n/an/a 8.20n/an/an/an/an/an/a



Kyushu University

Curated by ChEMBL


Assay Description
Inhibition of full-length human PDE4B2 assessed as cAMP hydrolysis preincubated for 20 mins followed by cAMP addition measured after 30 mins

Bioorg Med Chem Lett 24: 893-9 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.076
BindingDB Entry DOI: 10.7270/Q2GX4FHW
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM50495762
PNG
(CHEMBL3114945)
Show SMILES OC(=O)Cc1ccc(Nc2nc(nc3CCCS(=O)(=O)c23)-c2cc3ccccc3s2)cc1
Show InChI InChI=1S/C23H19N3O4S2/c27-20(28)12-14-7-9-16(10-8-14)24-23-21-17(5-3-11-32(21,29)30)25-22(26-23)19-13-15-4-1-2-6-18(15)31-19/h1-2,4,6-10,13H,3,5,11-12H2,(H,27,28)(H,24,25,26)
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n/an/a 8.30n/an/an/an/an/an/a



Kyushu University

Curated by ChEMBL


Assay Description
Inhibition of full-length human PDE4B2 assessed as cAMP hydrolysis preincubated for 20 mins followed by cAMP addition measured after 30 mins

Bioorg Med Chem Lett 24: 893-9 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.076
BindingDB Entry DOI: 10.7270/Q2GX4FHW
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM50495779
PNG
(CHEMBL3114953)
Show SMILES COc1ccc(cc1F)-c1nc2CCCS(=O)(=O)c2c(Nc2cc(F)c(CC(O)=O)cc2Cl)n1
Show InChI InChI=1S/C22H18ClF2N3O5S/c1-33-18-5-4-11(8-15(18)25)21-26-16-3-2-6-34(31,32)20(16)22(28-21)27-17-10-14(24)12(7-13(17)23)9-19(29)30/h4-5,7-8,10H,2-3,6,9H2,1H3,(H,29,30)(H,26,27,28)
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n/an/a 9.90n/an/an/an/an/an/a



Kyushu University

Curated by ChEMBL


Assay Description
Inhibition of full-length human PDE4B2 assessed as cAMP hydrolysis preincubated for 20 mins followed by cAMP addition measured after 30 mins

Bioorg Med Chem Lett 24: 893-9 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.076
BindingDB Entry DOI: 10.7270/Q2GX4FHW
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM50495781
PNG
(CHEMBL3114947)
Show SMILES COc1ccc(cc1F)-c1nc2CCCS(=O)(=O)c2c(Nc2ccc(CC(O)=O)cc2)n1
Show InChI InChI=1S/C22H20FN3O5S/c1-31-18-9-6-14(12-16(18)23)21-25-17-3-2-10-32(29,30)20(17)22(26-21)24-15-7-4-13(5-8-15)11-19(27)28/h4-9,12H,2-3,10-11H2,1H3,(H,27,28)(H,24,25,26)
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n/an/a 10n/an/an/an/an/an/a



Kyushu University

Curated by ChEMBL


Assay Description
Inhibition of full-length human PDE4B2 assessed as cAMP hydrolysis preincubated for 20 mins followed by cAMP addition measured after 30 mins

Bioorg Med Chem Lett 24: 893-9 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.076
BindingDB Entry DOI: 10.7270/Q2GX4FHW
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM50495789
PNG
(CHEMBL3114936)
Show SMILES CC(=O)c1ccc(cc1)-c1nc2CCCS(=O)(=O)c2c(Nc2ccc(CC(O)=O)cc2)n1
Show InChI InChI=1S/C23H21N3O5S/c1-14(27)16-6-8-17(9-7-16)22-25-19-3-2-12-32(30,31)21(19)23(26-22)24-18-10-4-15(5-11-18)13-20(28)29/h4-11H,2-3,12-13H2,1H3,(H,28,29)(H,24,25,26)
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n/an/a 10n/an/an/an/an/an/a



Kyushu University

Curated by ChEMBL


Assay Description
Inhibition of full-length human PDE4B2 assessed as cAMP hydrolysis preincubated for 20 mins followed by cAMP addition measured after 30 mins

Bioorg Med Chem Lett 24: 893-9 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.076
BindingDB Entry DOI: 10.7270/Q2GX4FHW
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM50495771
PNG
(CHEMBL3112613)
Show SMILES COc1ccc(cc1)-c1nc2CCCSc2c(Nc2ccc(CC(O)=O)cc2)n1
Show InChI InChI=1S/C22H21N3O3S/c1-28-17-10-6-15(7-11-17)21-24-18-3-2-12-29-20(18)22(25-21)23-16-8-4-14(5-9-16)13-19(26)27/h4-11H,2-3,12-13H2,1H3,(H,26,27)(H,23,24,25)
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n/an/a 11n/an/an/an/an/an/a



Kyushu University

Curated by ChEMBL


Assay Description
Inhibition of full-length human PDE4B2 assessed as cAMP hydrolysis preincubated for 20 mins followed by cAMP addition measured after 30 mins

Bioorg Med Chem Lett 24: 893-9 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.076
BindingDB Entry DOI: 10.7270/Q2GX4FHW
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM50495774
PNG
(CHEMBL3114940)
Show SMILES COc1ccc(cc1Cl)-c1nc2CCCS(=O)(=O)c2c(Nc2ccc(CC(O)=O)cc2)n1
Show InChI InChI=1S/C22H20ClN3O5S/c1-31-18-9-6-14(12-16(18)23)21-25-17-3-2-10-32(29,30)20(17)22(26-21)24-15-7-4-13(5-8-15)11-19(27)28/h4-9,12H,2-3,10-11H2,1H3,(H,27,28)(H,24,25,26)
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n/an/a 13n/an/an/an/an/an/a



Kyushu University

Curated by ChEMBL


Assay Description
Inhibition of full-length human PDE4B2 assessed as cAMP hydrolysis preincubated for 20 mins followed by cAMP addition measured after 30 mins

Bioorg Med Chem Lett 24: 893-9 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.076
BindingDB Entry DOI: 10.7270/Q2GX4FHW
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM50495763
PNG
(CHEMBL3114944)
Show SMILES OC(=O)Cc1ccc(Nc2nc(nc3CCCS(=O)(=O)c23)-c2ccc3c(F)cccc3c2)cc1
Show InChI InChI=1S/C25H20FN3O4S/c26-20-4-1-3-16-14-17(8-11-19(16)20)24-28-21-5-2-12-34(32,33)23(21)25(29-24)27-18-9-6-15(7-10-18)13-22(30)31/h1,3-4,6-11,14H,2,5,12-13H2,(H,30,31)(H,27,28,29)
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n/an/a 14n/an/an/an/an/an/a



Kyushu University

Curated by ChEMBL


Assay Description
Inhibition of full-length human PDE4B2 assessed as cAMP hydrolysis preincubated for 20 mins followed by cAMP addition measured after 30 mins

Bioorg Med Chem Lett 24: 893-9 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.076
BindingDB Entry DOI: 10.7270/Q2GX4FHW
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM50495761
PNG
(CHEMBL3114949)
Show SMILES COc1ccc(cc1F)-c1nc2CCCS(=O)(=O)c2c(Nc2cc(F)c(CC(O)=O)cc2F)n1
Show InChI InChI=1S/C22H18F3N3O5S/c1-33-18-5-4-11(7-15(18)25)21-26-16-3-2-6-34(31,32)20(16)22(28-21)27-17-10-13(23)12(8-14(17)24)9-19(29)30/h4-5,7-8,10H,2-3,6,9H2,1H3,(H,29,30)(H,26,27,28)
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n/an/a 16n/an/an/an/an/an/a



Kyushu University

Curated by ChEMBL


Assay Description
Inhibition of full-length human PDE4B2 assessed as cAMP hydrolysis preincubated for 20 mins followed by cAMP addition measured after 30 mins

Bioorg Med Chem Lett 24: 893-9 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.076
BindingDB Entry DOI: 10.7270/Q2GX4FHW
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM50495760
PNG
(CHEMBL3114941)
Show SMILES OC(=O)Cc1ccc(Nc2nc(nc3CCCS(=O)(=O)c23)-c2ccc3ccccc3c2)cc1
Show InChI InChI=1S/C25H21N3O4S/c29-22(30)14-16-7-11-20(12-8-16)26-25-23-21(6-3-13-33(23,31)32)27-24(28-25)19-10-9-17-4-1-2-5-18(17)15-19/h1-2,4-5,7-12,15H,3,6,13-14H2,(H,29,30)(H,26,27,28)
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n/an/a 19n/an/an/an/an/an/a



Kyushu University

Curated by ChEMBL


Assay Description
Inhibition of full-length human PDE4B2 assessed as cAMP hydrolysis preincubated for 20 mins followed by cAMP addition measured after 30 mins

Bioorg Med Chem Lett 24: 893-9 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.076
BindingDB Entry DOI: 10.7270/Q2GX4FHW
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM50495782
PNG
(CHEMBL3114946)
Show SMILES OC(=O)Cc1ccc(Nc2nc(nc3CCCS(=O)(=O)c23)-c2cc3ccccc3o2)cc1
Show InChI InChI=1S/C23H19N3O5S/c27-20(28)12-14-7-9-16(10-8-14)24-23-21-17(5-3-11-32(21,29)30)25-22(26-23)19-13-15-4-1-2-6-18(15)31-19/h1-2,4,6-10,13H,3,5,11-12H2,(H,27,28)(H,24,25,26)
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n/an/a 20n/an/an/an/an/an/a



Kyushu University

Curated by ChEMBL


Assay Description
Inhibition of full-length human PDE4B2 assessed as cAMP hydrolysis preincubated for 20 mins followed by cAMP addition measured after 30 mins

Bioorg Med Chem Lett 24: 893-9 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.076
BindingDB Entry DOI: 10.7270/Q2GX4FHW
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM50495764
PNG
(CHEMBL3114943)
Show SMILES COc1cccc2cc(ccc12)-c1nc2CCCS(=O)(=O)c2c(Nc2ccc(CC(O)=O)cc2)n1
Show InChI InChI=1S/C26H23N3O5S/c1-34-22-6-2-4-17-15-18(9-12-20(17)22)25-28-21-5-3-13-35(32,33)24(21)26(29-25)27-19-10-7-16(8-11-19)14-23(30)31/h2,4,6-12,15H,3,5,13-14H2,1H3,(H,30,31)(H,27,28,29)
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n/an/a 30n/an/an/an/an/an/a



Kyushu University

Curated by ChEMBL


Assay Description
Inhibition of full-length human PDE4B2 assessed as cAMP hydrolysis preincubated for 20 mins followed by cAMP addition measured after 30 mins

Bioorg Med Chem Lett 24: 893-9 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.076
BindingDB Entry DOI: 10.7270/Q2GX4FHW
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM50495772
PNG
(CHEMBL3114926)
Show SMILES OC(=O)Cc1ccc(Nc2nc(nc3CCCSc23)-c2ccc(cc2)C#N)cc1
Show InChI InChI=1S/C22H18N4O2S/c23-13-15-3-7-16(8-4-15)21-25-18-2-1-11-29-20(18)22(26-21)24-17-9-5-14(6-10-17)12-19(27)28/h3-10H,1-2,11-12H2,(H,27,28)(H,24,25,26)
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n/an/a 30n/an/an/an/an/an/a



Kyushu University

Curated by ChEMBL


Assay Description
Inhibition of full-length human PDE4B2 assessed as cAMP hydrolysis preincubated for 20 mins followed by cAMP addition measured after 30 mins

Bioorg Med Chem Lett 24: 893-9 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.076
BindingDB Entry DOI: 10.7270/Q2GX4FHW
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM50495769
PNG
(CHEMBL3114929)
Show SMILES CC(=O)c1ccc(cc1)-c1nc2CCCSc2c(Nc2ccc(CC(O)=O)cc2)n1
Show InChI InChI=1S/C23H21N3O3S/c1-14(27)16-6-8-17(9-7-16)22-25-19-3-2-12-30-21(19)23(26-22)24-18-10-4-15(5-11-18)13-20(28)29/h4-11H,2-3,12-13H2,1H3,(H,28,29)(H,24,25,26)
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Kyushu University

Curated by ChEMBL


Assay Description
Inhibition of full-length human PDE4B2 assessed as cAMP hydrolysis preincubated for 20 mins followed by cAMP addition measured after 30 mins

Bioorg Med Chem Lett 24: 893-9 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.076
BindingDB Entry DOI: 10.7270/Q2GX4FHW
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM50495766
PNG
(CHEMBL3114935)
Show SMILES CN(C)c1ccc(cc1)-c1nc2CCCS(=O)(=O)c2c(Nc2ccc(CC(O)=O)cc2)n1
Show InChI InChI=1S/C23H24N4O4S/c1-27(2)18-11-7-16(8-12-18)22-25-19-4-3-13-32(30,31)21(19)23(26-22)24-17-9-5-15(6-10-17)14-20(28)29/h5-12H,3-4,13-14H2,1-2H3,(H,28,29)(H,24,25,26)
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Kyushu University

Curated by ChEMBL


Assay Description
Inhibition of full-length human PDE4B2 assessed as cAMP hydrolysis preincubated for 20 mins followed by cAMP addition measured after 30 mins

Bioorg Med Chem Lett 24: 893-9 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.076
BindingDB Entry DOI: 10.7270/Q2GX4FHW
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM50495783
PNG
(CHEMBL3114942)
Show SMILES OC(=O)Cc1ccc(Nc2nc(nc3CCCS(=O)(=O)c23)-c2ccc(cc2)-c2ccccc2)cc1
Show InChI InChI=1S/C27H23N3O4S/c31-24(32)17-18-8-14-22(15-9-18)28-27-25-23(7-4-16-35(25,33)34)29-26(30-27)21-12-10-20(11-13-21)19-5-2-1-3-6-19/h1-3,5-6,8-15H,4,7,16-17H2,(H,31,32)(H,28,29,30)
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Kyushu University

Curated by ChEMBL


Assay Description
Inhibition of full-length human PDE4B2 assessed as cAMP hydrolysis preincubated for 20 mins followed by cAMP addition measured after 30 mins

Bioorg Med Chem Lett 24: 893-9 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.076
BindingDB Entry DOI: 10.7270/Q2GX4FHW
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM50495786
PNG
(CHEMBL3114928)
Show SMILES CN(C)c1ccc(cc1)-c1nc2CCCSc2c(Nc2ccc(CC(O)=O)cc2)n1
Show InChI InChI=1S/C23H24N4O2S/c1-27(2)18-11-7-16(8-12-18)22-25-19-4-3-13-30-21(19)23(26-22)24-17-9-5-15(6-10-17)14-20(28)29/h5-12H,3-4,13-14H2,1-2H3,(H,28,29)(H,24,25,26)
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Kyushu University

Curated by ChEMBL


Assay Description
Inhibition of full-length human PDE4B2 assessed as cAMP hydrolysis preincubated for 20 mins followed by cAMP addition measured after 30 mins

Bioorg Med Chem Lett 24: 893-9 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.076
BindingDB Entry DOI: 10.7270/Q2GX4FHW
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM50495767
PNG
(CHEMBL3114934)
Show SMILES COc1ccc(cc1)-c1nc2CCCS(=O)(=O)c2c(Nc2ccc(CC(O)=O)cc2)n1
Show InChI InChI=1S/C22H21N3O5S/c1-30-17-10-6-15(7-11-17)21-24-18-3-2-12-31(28,29)20(18)22(25-21)23-16-8-4-14(5-9-16)13-19(26)27/h4-11H,2-3,12-13H2,1H3,(H,26,27)(H,23,24,25)
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Kyushu University

Curated by ChEMBL


Assay Description
Inhibition of full-length human PDE4B2 assessed as cAMP hydrolysis preincubated for 20 mins followed by cAMP addition measured after 30 mins

Bioorg Med Chem Lett 24: 893-9 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.076
BindingDB Entry DOI: 10.7270/Q2GX4FHW
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM50495765
PNG
(CHEMBL3114939)
Show SMILES COc1ccc(c(F)c1F)-c1nc2CCCS(=O)(=O)c2c(Nc2ccc(CC(O)=O)cc2)n1
Show InChI InChI=1S/C22H19F2N3O5S/c1-32-16-9-8-14(18(23)19(16)24)21-26-15-3-2-10-33(30,31)20(15)22(27-21)25-13-6-4-12(5-7-13)11-17(28)29/h4-9H,2-3,10-11H2,1H3,(H,28,29)(H,25,26,27)
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Kyushu University

Curated by ChEMBL


Assay Description
Inhibition of full-length human PDE4B2 assessed as cAMP hydrolysis preincubated for 20 mins followed by cAMP addition measured after 30 mins

Bioorg Med Chem Lett 24: 893-9 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.076
BindingDB Entry DOI: 10.7270/Q2GX4FHW
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM50495759
PNG
(CHEMBL3114952)
Show SMILES COc1ccc(cc1F)-c1nc2CCCS(=O)(=O)c2c(Nc2cc(Cl)c(CC(O)=O)cc2Cl)n1
Show InChI InChI=1S/C22H18Cl2FN3O5S/c1-33-18-5-4-11(8-15(18)25)21-26-16-3-2-6-34(31,32)20(16)22(28-21)27-17-10-13(23)12(7-14(17)24)9-19(29)30/h4-5,7-8,10H,2-3,6,9H2,1H3,(H,29,30)(H,26,27,28)
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Kyushu University

Curated by ChEMBL


Assay Description
Inhibition of full-length human PDE4B2 assessed as cAMP hydrolysis preincubated for 20 mins followed by cAMP addition measured after 30 mins

Bioorg Med Chem Lett 24: 893-9 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.076
BindingDB Entry DOI: 10.7270/Q2GX4FHW
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM50495784
PNG
(CHEMBL3114938)
Show SMILES CN(C)c1ccc(cn1)-c1nc2CCCS(=O)(=O)c2c(Nc2ccc(CC(O)=O)cc2)n1
Show InChI InChI=1S/C22H23N5O4S/c1-27(2)18-10-7-15(13-23-18)21-25-17-4-3-11-32(30,31)20(17)22(26-21)24-16-8-5-14(6-9-16)12-19(28)29/h5-10,13H,3-4,11-12H2,1-2H3,(H,28,29)(H,24,25,26)
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Kyushu University

Curated by ChEMBL


Assay Description
Inhibition of full-length human PDE4B2 assessed as cAMP hydrolysis preincubated for 20 mins followed by cAMP addition measured after 30 mins

Bioorg Med Chem Lett 24: 893-9 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.076
BindingDB Entry DOI: 10.7270/Q2GX4FHW
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM50495792
PNG
(CHEMBL3114923)
Show SMILES OC(=O)Cc1ccc(Nc2nc(nc3CCCSc23)-c2cccc(F)c2)cc1
Show InChI InChI=1S/C21H18FN3O2S/c22-15-4-1-3-14(12-15)20-24-17-5-2-10-28-19(17)21(25-20)23-16-8-6-13(7-9-16)11-18(26)27/h1,3-4,6-9,12H,2,5,10-11H2,(H,26,27)(H,23,24,25)
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Kyushu University

Curated by ChEMBL


Assay Description
Inhibition of full-length human PDE4B2 assessed as cAMP hydrolysis preincubated for 20 mins followed by cAMP addition measured after 30 mins

Bioorg Med Chem Lett 24: 893-9 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.076
BindingDB Entry DOI: 10.7270/Q2GX4FHW
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM50495780
PNG
(CHEMBL3114951)
Show SMILES COc1ccc(cc1F)-c1nc2CCCS(=O)(=O)c2c(Nc2ccc(CC(O)=O)c(Cl)c2)n1
Show InChI InChI=1S/C22H19ClFN3O5S/c1-32-18-7-5-13(9-16(18)24)21-26-17-3-2-8-33(30,31)20(17)22(27-21)25-14-6-4-12(10-19(28)29)15(23)11-14/h4-7,9,11H,2-3,8,10H2,1H3,(H,28,29)(H,25,26,27)
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Kyushu University

Curated by ChEMBL


Assay Description
Inhibition of full-length human PDE4B2 assessed as cAMP hydrolysis preincubated for 20 mins followed by cAMP addition measured after 30 mins

Bioorg Med Chem Lett 24: 893-9 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.076
BindingDB Entry DOI: 10.7270/Q2GX4FHW
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM50491754
PNG
(CHEMBL2385756)
Show SMILES CCCCNC(=O)Cc1ccc(Nc2nc(nc3CCCS(=O)(=O)c23)-c2ccccc2)cc1
Show InChI InChI=1S/C25H28N4O3S/c1-2-3-15-26-22(30)17-18-11-13-20(14-12-18)27-25-23-21(10-7-16-33(23,31)32)28-24(29-25)19-8-5-4-6-9-19/h4-6,8-9,11-14H,2-3,7,10,15-17H2,1H3,(H,26,30)(H,27,28,29)
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Kyushu University

Curated by ChEMBL


Assay Description
Inhibition of full-length human PDE4B2 assessed as cAMP hydrolysis preincubated for 20 mins followed by cAMP addition measured after 30 mins

Bioorg Med Chem Lett 24: 893-9 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.076
BindingDB Entry DOI: 10.7270/Q2GX4FHW
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM50495785
PNG
(CHEMBL3114933)
Show SMILES COc1ccc(cc1Cl)-c1nc2CCCSc2c(Nc2ccc(CC(O)=O)cc2)n1
Show InChI InChI=1S/C22H20ClN3O3S/c1-29-18-9-6-14(12-16(18)23)21-25-17-3-2-10-30-20(17)22(26-21)24-15-7-4-13(5-8-15)11-19(27)28/h4-9,12H,2-3,10-11H2,1H3,(H,27,28)(H,24,25,26)
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Kyushu University

Curated by ChEMBL


Assay Description
Inhibition of full-length human PDE4B2 assessed as cAMP hydrolysis preincubated for 20 mins followed by cAMP addition measured after 30 mins

Bioorg Med Chem Lett 24: 893-9 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.076
BindingDB Entry DOI: 10.7270/Q2GX4FHW
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM50495773
PNG
(CHEMBL3114921)
Show SMILES COc1ccc(cc1F)-c1nc2CCCS(=O)(=O)c2c(Nc2ccc(CC(=O)NCC(C)(C)C)cc2)n1
Show InChI InChI=1S/C27H31FN4O4S/c1-27(2,3)16-29-23(33)14-17-7-10-19(11-8-17)30-26-24-21(6-5-13-37(24,34)35)31-25(32-26)18-9-12-22(36-4)20(28)15-18/h7-12,15H,5-6,13-14,16H2,1-4H3,(H,29,33)(H,30,31,32)
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Kyushu University

Curated by ChEMBL


Assay Description
Inhibition of full-length human PDE4B2 assessed as cAMP hydrolysis preincubated for 20 mins followed by cAMP addition measured after 30 mins

Bioorg Med Chem Lett 24: 893-9 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.076
BindingDB Entry DOI: 10.7270/Q2GX4FHW
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM50495770
PNG
(CHEMBL3114927)
Show SMILES COc1cccc(c1)-c1nc2CCCSc2c(Nc2ccc(CC(O)=O)cc2)n1
Show InChI InChI=1S/C22H21N3O3S/c1-28-17-5-2-4-15(13-17)21-24-18-6-3-11-29-20(18)22(25-21)23-16-9-7-14(8-10-16)12-19(26)27/h2,4-5,7-10,13H,3,6,11-12H2,1H3,(H,26,27)(H,23,24,25)
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Kyushu University

Curated by ChEMBL


Assay Description
Inhibition of full-length human PDE4B2 assessed as cAMP hydrolysis preincubated for 20 mins followed by cAMP addition measured after 30 mins

Bioorg Med Chem Lett 24: 893-9 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.076
BindingDB Entry DOI: 10.7270/Q2GX4FHW
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM50495776
PNG
(CHEMBL3114924)
Show SMILES OC(=O)Cc1ccc(Nc2nc(nc3CCCSc23)-c2ccc(F)cc2)cc1
Show InChI InChI=1S/C21H18FN3O2S/c22-15-7-5-14(6-8-15)20-24-17-2-1-11-28-19(17)21(25-20)23-16-9-3-13(4-10-16)12-18(26)27/h3-10H,1-2,11-12H2,(H,26,27)(H,23,24,25)
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Kyushu University

Curated by ChEMBL


Assay Description
Inhibition of full-length human PDE4B2 assessed as cAMP hydrolysis preincubated for 20 mins followed by cAMP addition measured after 30 mins

Bioorg Med Chem Lett 24: 893-9 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.076
BindingDB Entry DOI: 10.7270/Q2GX4FHW
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM50495790
PNG
(CHEMBL3114925)
Show SMILES OC(=O)Cc1ccc(Nc2nc(nc3CCCSc23)-c2ccc(Cl)cc2)cc1
Show InChI InChI=1S/C21H18ClN3O2S/c22-15-7-5-14(6-8-15)20-24-17-2-1-11-28-19(17)21(25-20)23-16-9-3-13(4-10-16)12-18(26)27/h3-10H,1-2,11-12H2,(H,26,27)(H,23,24,25)
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Kyushu University

Curated by ChEMBL


Assay Description
Inhibition of full-length human PDE4B2 assessed as cAMP hydrolysis preincubated for 20 mins followed by cAMP addition measured after 30 mins

Bioorg Med Chem Lett 24: 893-9 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.076
BindingDB Entry DOI: 10.7270/Q2GX4FHW
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM50495758
PNG
(CHEMBL3114930)
Show SMILES COc1ccc(cn1)-c1nc2CCCSc2c(Nc2ccc(CC(O)=O)cc2)n1
Show InChI InChI=1S/C21H20N4O3S/c1-28-17-9-6-14(12-22-17)20-24-16-3-2-10-29-19(16)21(25-20)23-15-7-4-13(5-8-15)11-18(26)27/h4-9,12H,2-3,10-11H2,1H3,(H,26,27)(H,23,24,25)
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Kyushu University

Curated by ChEMBL


Assay Description
Inhibition of full-length human PDE4B2 assessed as cAMP hydrolysis preincubated for 20 mins followed by cAMP addition measured after 30 mins

Bioorg Med Chem Lett 24: 893-9 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.076
BindingDB Entry DOI: 10.7270/Q2GX4FHW
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM50495768
PNG
(CHEMBL3114931)
Show SMILES CN(C)c1ccc(cn1)-c1nc2CCCSc2c(Nc2ccc(CC(O)=O)cc2)n1
Show InChI InChI=1S/C22H23N5O2S/c1-27(2)18-10-7-15(13-23-18)21-25-17-4-3-11-30-20(17)22(26-21)24-16-8-5-14(6-9-16)12-19(28)29/h5-10,13H,3-4,11-12H2,1-2H3,(H,28,29)(H,24,25,26)
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Kyushu University

Curated by ChEMBL


Assay Description
Inhibition of full-length human PDE4B2 assessed as cAMP hydrolysis preincubated for 20 mins followed by cAMP addition measured after 30 mins

Bioorg Med Chem Lett 24: 893-9 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.076
BindingDB Entry DOI: 10.7270/Q2GX4FHW
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM50495775
PNG
(CHEMBL3114932)
Show SMILES COc1ccc(c(F)c1F)-c1nc2CCCSc2c(Nc2ccc(CC(O)=O)cc2)n1
Show InChI InChI=1S/C22H19F2N3O3S/c1-30-16-9-8-14(18(23)19(16)24)21-26-15-3-2-10-31-20(15)22(27-21)25-13-6-4-12(5-7-13)11-17(28)29/h4-9H,2-3,10-11H2,1H3,(H,28,29)(H,25,26,27)
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Kyushu University

Curated by ChEMBL


Assay Description
Inhibition of full-length human PDE4B2 assessed as cAMP hydrolysis preincubated for 20 mins followed by cAMP addition measured after 30 mins

Bioorg Med Chem Lett 24: 893-9 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.076
BindingDB Entry DOI: 10.7270/Q2GX4FHW
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM50491740
PNG
(CHEMBL2385749)
Show SMILES OC(=O)Cc1ccc(Nc2nc(nc3CCCS(=O)(=O)c23)-c2ccccc2)cc1
Show InChI InChI=1S/C21H19N3O4S/c25-18(26)13-14-8-10-16(11-9-14)22-21-19-17(7-4-12-29(19,27)28)23-20(24-21)15-5-2-1-3-6-15/h1-3,5-6,8-11H,4,7,12-13H2,(H,25,26)(H,22,23,24)
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Kyushu University

Curated by ChEMBL


Assay Description
Inhibition of full-length human PDE4B2 assessed as cAMP hydrolysis preincubated for 20 mins followed by cAMP addition measured after 30 mins

Bioorg Med Chem Lett 24: 893-9 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.076
BindingDB Entry DOI: 10.7270/Q2GX4FHW
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D


(Homo sapiens (Human))		BDBM50491754
PNG
(CHEMBL2385756)
Show SMILES CCCCNC(=O)Cc1ccc(Nc2nc(nc3CCCS(=O)(=O)c23)-c2ccccc2)cc1
Show InChI InChI=1S/C25H28N4O3S/c1-2-3-15-26-22(30)17-18-11-13-20(14-12-18)27-25-23-21(10-7-16-33(23,31)32)28-24(29-25)19-8-5-4-6-9-19/h4-6,8-9,11-14H,2-3,7,10,15-17H2,1H3,(H,26,30)(H,27,28,29)
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Kyushu University

Curated by ChEMBL


Assay Description
Inhibition of full-length human PDE4D2 assessed as cAMP hydrolysis preincubated for 20 mins followed by cAMP addition measured after 30 mins

Bioorg Med Chem Lett 24: 893-9 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.076
BindingDB Entry DOI: 10.7270/Q2GX4FHW
More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (Human))		BDBM50338244
PNG
(6-(4-fluorobenzyl)-2-ureido-5,6-dihydro-4H-thieno[...)
Show SMILES NC(=O)Nc1sc-2c(CCc3c-2cnn3Cc2ccc(F)cc2)c1C(N)=O
Show InChI InChI=1S/C18H16FN5O2S/c19-10-3-1-9(2-4-10)8-24-13-6-5-11-14(16(20)25)17(23-18(21)26)27-15(11)12(13)7-22-24/h1-4,7H,5-6,8H2,(H2,20,25)(H3,21,23,26)
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n/an/a 200n/an/an/an/an/an/a



Kyorin Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human IKK-beta by substrate phosphorylation assay

Bioorg Med Chem Lett 21: 1758-62 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.069
BindingDB Entry DOI: 10.7270/Q2TX3FPV
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM50491761
PNG
(CHEMBL2385573)
Show SMILES OC(=O)Cc1ccc(Nc2nc(nc3CCCSc23)-c2ccccc2)cc1
Show InChI InChI=1S/C21H19N3O2S/c25-18(26)13-14-8-10-16(11-9-14)22-21-19-17(7-4-12-27-19)23-20(24-21)15-5-2-1-3-6-15/h1-3,5-6,8-11H,4,7,12-13H2,(H,25,26)(H,22,23,24)
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Kyushu University

Curated by ChEMBL


Assay Description
Inhibition of full-length human PDE4B2 assessed as cAMP hydrolysis preincubated for 20 mins followed by cAMP addition measured after 30 mins

Bioorg Med Chem Lett 24: 893-9 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.076
BindingDB Entry DOI: 10.7270/Q2GX4FHW
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM50495756
PNG
(CHEMBL3114937)
Show SMILES COc1ccc(cn1)-c1nc2CCCS(=O)(=O)c2c(Nc2ccc(CC(O)=O)cc2)n1
Show InChI InChI=1S/C21H20N4O5S/c1-30-17-9-6-14(12-22-17)20-24-16-3-2-10-31(28,29)19(16)21(25-20)23-15-7-4-13(5-8-15)11-18(26)27/h4-9,12H,2-3,10-11H2,1H3,(H,26,27)(H,23,24,25)
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Kyushu University

Curated by ChEMBL


Assay Description
Inhibition of full-length human PDE4B2 assessed as cAMP hydrolysis preincubated for 20 mins followed by cAMP addition measured after 30 mins

Bioorg Med Chem Lett 24: 893-9 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.076
BindingDB Entry DOI: 10.7270/Q2GX4FHW
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D


(Homo sapiens (Human))		BDBM50491754
PNG
(CHEMBL2385756)
Show SMILES CCCCNC(=O)Cc1ccc(Nc2nc(nc3CCCS(=O)(=O)c23)-c2ccccc2)cc1
Show InChI InChI=1S/C25H28N4O3S/c1-2-3-15-26-22(30)17-18-11-13-20(14-12-18)27-25-23-21(10-7-16-33(23,31)32)28-24(29-25)19-8-5-4-6-9-19/h4-6,8-9,11-14H,2-3,7,10,15-17H2,1H3,(H,26,30)(H,27,28,29)
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n/an/a 260n/an/an/an/an/an/a



Kyushu University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PDE4D (78 to 508)

Bioorg Med Chem Lett 24: 893-9 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.076
BindingDB Entry DOI: 10.7270/Q2GX4FHW
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D


(Homo sapiens (Human))		BDBM50495771
PNG
(CHEMBL3112613)
Show SMILES COc1ccc(cc1)-c1nc2CCCSc2c(Nc2ccc(CC(O)=O)cc2)n1
Show InChI InChI=1S/C22H21N3O3S/c1-28-17-10-6-15(7-11-17)21-24-18-3-2-12-29-20(18)22(25-21)23-16-8-4-14(5-9-16)13-19(26)27/h4-11H,2-3,12-13H2,1H3,(H,26,27)(H,23,24,25)
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Kyushu University

Curated by ChEMBL


Assay Description
Inhibition of full-length human PDE4D2 assessed as cAMP hydrolysis preincubated for 20 mins followed by cAMP addition measured after 30 mins

Bioorg Med Chem Lett 24: 893-9 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.076
BindingDB Entry DOI: 10.7270/Q2GX4FHW
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D


(Homo sapiens (Human))		BDBM50495772
PNG
(CHEMBL3114926)
Show SMILES OC(=O)Cc1ccc(Nc2nc(nc3CCCSc23)-c2ccc(cc2)C#N)cc1
Show InChI InChI=1S/C22H18N4O2S/c23-13-15-3-7-16(8-4-15)21-25-18-2-1-11-29-20(18)22(26-21)24-17-9-5-14(6-10-17)12-19(27)28/h3-10H,1-2,11-12H2,(H,27,28)(H,24,25,26)
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Kyushu University

Curated by ChEMBL


Assay Description
Inhibition of full-length human PDE4D2 assessed as cAMP hydrolysis preincubated for 20 mins followed by cAMP addition measured after 30 mins

Bioorg Med Chem Lett 24: 893-9 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.076
BindingDB Entry DOI: 10.7270/Q2GX4FHW
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D


(Homo sapiens (Human))		BDBM50495764
PNG
(CHEMBL3114943)
Show SMILES COc1cccc2cc(ccc12)-c1nc2CCCS(=O)(=O)c2c(Nc2ccc(CC(O)=O)cc2)n1
Show InChI InChI=1S/C26H23N3O5S/c1-34-22-6-2-4-17-15-18(9-12-20(17)22)25-28-21-5-3-13-35(32,33)24(21)26(29-25)27-19-10-7-16(8-11-19)14-23(30)31/h2,4,6-12,15H,3,5,13-14H2,1H3,(H,30,31)(H,27,28,29)
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Kyushu University

Curated by ChEMBL


Assay Description
Inhibition of full-length human PDE4D2 assessed as cAMP hydrolysis preincubated for 20 mins followed by cAMP addition measured after 30 mins

Bioorg Med Chem Lett 24: 893-9 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.076
BindingDB Entry DOI: 10.7270/Q2GX4FHW
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D


(Homo sapiens (Human))		BDBM50495773
PNG
(CHEMBL3114921)
Show SMILES COc1ccc(cc1F)-c1nc2CCCS(=O)(=O)c2c(Nc2ccc(CC(=O)NCC(C)(C)C)cc2)n1
Show InChI InChI=1S/C27H31FN4O4S/c1-27(2,3)16-29-23(33)14-17-7-10-19(11-8-17)30-26-24-21(6-5-13-37(24,34)35)31-25(32-26)18-9-12-22(36-4)20(28)15-18/h7-12,15H,5-6,13-14,16H2,1-4H3,(H,29,33)(H,30,31,32)
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Kyushu University

Curated by ChEMBL


Assay Description
Inhibition of full-length human PDE4D2 assessed as cAMP hydrolysis preincubated for 20 mins followed by cAMP addition measured after 30 mins

Bioorg Med Chem Lett 24: 893-9 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.076
BindingDB Entry DOI: 10.7270/Q2GX4FHW
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D


(Homo sapiens (Human))		BDBM50495762
PNG
(CHEMBL3114945)
Show SMILES OC(=O)Cc1ccc(Nc2nc(nc3CCCS(=O)(=O)c23)-c2cc3ccccc3s2)cc1
Show InChI InChI=1S/C23H19N3O4S2/c27-20(28)12-14-7-9-16(10-8-14)24-23-21-17(5-3-11-32(21,29)30)25-22(26-23)19-13-15-4-1-2-6-18(15)31-19/h1-2,4,6-10,13H,3,5,11-12H2,(H,27,28)(H,24,25,26)
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Kyushu University

Curated by ChEMBL


Assay Description
Inhibition of full-length human PDE4D2 assessed as cAMP hydrolysis preincubated for 20 mins followed by cAMP addition measured after 30 mins

Bioorg Med Chem Lett 24: 893-9 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.076
BindingDB Entry DOI: 10.7270/Q2GX4FHW
More data for this
Ligand-Target Pair
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