BindingDB PrimarySearch

Found 312 hits with Last Name = 'velu' and Initial = 'se'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Bifunctional dihydrofolate reductase-thymidylate synthase (Trypanosoma cruzi)	BDBM50320792 (CHEMBL1165388 \| Ethyl4-(5-[(2,4-diamino-6-quinazol...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid PDB UniChem Similars	MMDB PDB Article PubMed	1.30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Alabama Curated by ChEMBL					Assay Description Inhibition of Trypanosoma cruzi DHFR by spectrophotometric assay				Bioorg Med Chem 18: 4056-66 (2010) Article DOI: 10.1016/j.bmc.2010.04.020 BindingDB Entry DOI: 10.7270/Q26110GG
University of Alabama Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Bifunctional dihydrofolate reductase-thymidylate synthase (Trypanosoma cruzi)	BDBM50320791 (6-[(3,4-Dimethoxyanilino)methyl]-2,4-quinazolinedi...) Show SMILES COc1ccc(NCc2ccc3nc(N)nc(N)c3c2)cc1OC Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.60	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Alabama Curated by ChEMBL					Assay Description Inhibition of Trypanosoma cruzi DHFR by spectrophotometric assay				Bioorg Med Chem 18: 4056-66 (2010) Article DOI: 10.1016/j.bmc.2010.04.020 BindingDB Entry DOI: 10.7270/Q26110GG
University of Alabama Curated by ChEMBL					More data for this Ligand-Target Pair
Bifunctional dihydrofolate reductase-thymidylate synthase (Trypanosoma cruzi)	BDBM50320793 (CHEMBL1165305 \| Methyl5-(5-[(2,4-diamino-6-quinazo...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.60	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Alabama Curated by ChEMBL					Assay Description Inhibition of Trypanosoma cruzi DHFR by spectrophotometric assay				Bioorg Med Chem 18: 4056-66 (2010) Article DOI: 10.1016/j.bmc.2010.04.020 BindingDB Entry DOI: 10.7270/Q26110GG
University of Alabama Curated by ChEMBL					More data for this Ligand-Target Pair
Bifunctional dihydrofolate reductase-thymidylate synthase (Trypanosoma cruzi)	BDBM50320794 (CHEMBL1165306 \| Methyl4-[(5-[(2,4-diamino-6-quinaz...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	3.30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Alabama Curated by ChEMBL					Assay Description Inhibition of Trypanosoma cruzi DHFR by spectrophotometric assay				Bioorg Med Chem 18: 4056-66 (2010) Article DOI: 10.1016/j.bmc.2010.04.020 BindingDB Entry DOI: 10.7270/Q26110GG
University of Alabama Curated by ChEMBL					More data for this Ligand-Target Pair
Bifunctional dihydrofolate reductase-thymidylate synthase (Trypanosoma cruzi)	BDBM50320790 (4-(5-[(2,4-diamino-6-quinazolinyl)methyl]amino-2-m...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	3.60	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Alabama Curated by ChEMBL					Assay Description Inhibition of Trypanosoma cruzi DHFR by spectrophotometric assay				Bioorg Med Chem 18: 4056-66 (2010) Article DOI: 10.1016/j.bmc.2010.04.020 BindingDB Entry DOI: 10.7270/Q26110GG
University of Alabama Curated by ChEMBL					More data for this Ligand-Target Pair
Bifunctional dihydrofolate reductase-thymidylate synthase (Trypanosoma cruzi)	BDBM50320791 (6-[(3,4-Dimethoxyanilino)methyl]-2,4-quinazolinedi...) Show SMILES COc1ccc(NCc2ccc3nc(N)nc(N)c3c2)cc1OC Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	4.75	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Alabama Curated by ChEMBL					Assay Description Inhibition of Trypanosoma cruzi DHFR by Lineweaver-Burk plot				Bioorg Med Chem 18: 4056-66 (2010) Article DOI: 10.1016/j.bmc.2010.04.020 BindingDB Entry DOI: 10.7270/Q26110GG
University of Alabama Curated by ChEMBL					More data for this Ligand-Target Pair
Bifunctional dihydrofolate reductase-thymidylate synthase (Trypanosoma cruzi)	BDBM50320792 (CHEMBL1165388 \| Ethyl4-(5-[(2,4-diamino-6-quinazol...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid PDB UniChem Similars	MMDB PDB Article PubMed	5.68	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Alabama Curated by ChEMBL					Assay Description Inhibition of Trypanosoma cruzi DHFR by Lineweaver-Burk plot				Bioorg Med Chem 18: 4056-66 (2010) Article DOI: 10.1016/j.bmc.2010.04.020 BindingDB Entry DOI: 10.7270/Q26110GG
University of Alabama Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Bifunctional dihydrofolate reductase-thymidylate synthase (Trypanosoma cruzi)	BDBM18268 (5-methyl-6-{[(3,4,5-trimethoxyphenyl)amino]methyl}...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	MMDB PDB Article PubMed	6.60	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Alabama Curated by ChEMBL					Assay Description Inhibition of Trypanosoma cruzi DHFR by spectrophotometric assay				Bioorg Med Chem 18: 4056-66 (2010) Article DOI: 10.1016/j.bmc.2010.04.020 BindingDB Entry DOI: 10.7270/Q26110GG
University of Alabama Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Dihydrofolate reductase (Homo sapiens (Human))	BDBM50320792 (CHEMBL1165388 \| Ethyl4-(5-[(2,4-diamino-6-quinazol...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	9.60	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Alabama Curated by ChEMBL					Assay Description Inhibition of human DHFR by spectrophotometric assay				Bioorg Med Chem 18: 4056-66 (2010) Article DOI: 10.1016/j.bmc.2010.04.020 BindingDB Entry DOI: 10.7270/Q26110GG
University of Alabama Curated by ChEMBL					More data for this Ligand-Target Pair
Dihydrofolate reductase (Homo sapiens (Human))	BDBM50320791 (6-[(3,4-Dimethoxyanilino)methyl]-2,4-quinazolinedi...) Show SMILES COc1ccc(NCc2ccc3nc(N)nc(N)c3c2)cc1OC Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	11.8	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Alabama Curated by ChEMBL					Assay Description Inhibition of human DHFR by spectrophotometric assay				Bioorg Med Chem 18: 4056-66 (2010) Article DOI: 10.1016/j.bmc.2010.04.020 BindingDB Entry DOI: 10.7270/Q26110GG
University of Alabama Curated by ChEMBL					More data for this Ligand-Target Pair
Dihydrofolate reductase (Homo sapiens (Human))	BDBM50320793 (CHEMBL1165305 \| Methyl5-(5-[(2,4-diamino-6-quinazo...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	13	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Alabama Curated by ChEMBL					Assay Description Inhibition of human DHFR by spectrophotometric assay				Bioorg Med Chem 18: 4056-66 (2010) Article DOI: 10.1016/j.bmc.2010.04.020 BindingDB Entry DOI: 10.7270/Q26110GG
University of Alabama Curated by ChEMBL					More data for this Ligand-Target Pair
Dihydrofolate reductase (Homo sapiens (Human))	BDBM50320794 (CHEMBL1165306 \| Methyl4-[(5-[(2,4-diamino-6-quinaz...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	24.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Alabama Curated by ChEMBL					Assay Description Inhibition of human DHFR by spectrophotometric assay				Bioorg Med Chem 18: 4056-66 (2010) Article DOI: 10.1016/j.bmc.2010.04.020 BindingDB Entry DOI: 10.7270/Q26110GG
University of Alabama Curated by ChEMBL					More data for this Ligand-Target Pair
Bifunctional dihydrofolate reductase-thymidylate synthase (Trypanosoma cruzi)	BDBM50320789 (CHEMBL1164234 \| methyl5-{5-[[(2,4-diamino-6-quinaz...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	24.9	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Alabama Curated by ChEMBL					Assay Description Inhibition of Trypanosoma cruzi DHFR by spectrophotometric assay				Bioorg Med Chem 18: 4056-66 (2010) Article DOI: 10.1016/j.bmc.2010.04.020 BindingDB Entry DOI: 10.7270/Q26110GG
University of Alabama Curated by ChEMBL					More data for this Ligand-Target Pair
Dihydrofolate reductase (Homo sapiens (Human))	BDBM50320790 (4-(5-[(2,4-diamino-6-quinazolinyl)methyl]amino-2-m...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	49.8	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Alabama Curated by ChEMBL					Assay Description Inhibition of human DHFR by spectrophotometric assay				Bioorg Med Chem 18: 4056-66 (2010) Article DOI: 10.1016/j.bmc.2010.04.020 BindingDB Entry DOI: 10.7270/Q26110GG
University of Alabama Curated by ChEMBL					More data for this Ligand-Target Pair
Dihydrofolate reductase (Homo sapiens (Human))	BDBM50320789 (CHEMBL1164234 \| methyl5-{5-[[(2,4-diamino-6-quinaz...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	188	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Alabama Curated by ChEMBL					Assay Description Inhibition of human DHFR by spectrophotometric assay				Bioorg Med Chem 18: 4056-66 (2010) Article DOI: 10.1016/j.bmc.2010.04.020 BindingDB Entry DOI: 10.7270/Q26110GG
University of Alabama Curated by ChEMBL					More data for this Ligand-Target Pair
Bifunctional dihydrofolate reductase-thymidylate synthase (Trypanosoma cruzi)	BDBM18268 (5-methyl-6-{[(3,4,5-trimethoxyphenyl)amino]methyl}...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	MMDB PDB Article PubMed	n/a	n/a	20.2	n/a	n/a	n/a	n/a	n/a	n/a
University of Alabama Curated by ChEMBL					Assay Description Inhibition of Trypanosoma cruzi DHFR by spectrophotometric assay				Bioorg Med Chem 18: 4056-66 (2010) Article DOI: 10.1016/j.bmc.2010.04.020 BindingDB Entry DOI: 10.7270/Q26110GG
University of Alabama Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Bifunctional dihydrofolate reductase-thymidylate synthase (Trypanosoma cruzi)	BDBM50320792 (CHEMBL1165388 \| Ethyl4-(5-[(2,4-diamino-6-quinazol...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid PDB UniChem Similars	MMDB PDB Article PubMed	n/a	n/a	23.8	n/a	n/a	n/a	n/a	n/a	n/a
University of Alabama Curated by ChEMBL					Assay Description Inhibition of Trypanosoma cruzi DHFR by spectrophotometric assay				Bioorg Med Chem 18: 4056-66 (2010) Article DOI: 10.1016/j.bmc.2010.04.020 BindingDB Entry DOI: 10.7270/Q26110GG
University of Alabama Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Bifunctional dihydrofolate reductase-thymidylate synthase (Trypanosoma cruzi)	BDBM50320793 (CHEMBL1165305 \| Methyl5-(5-[(2,4-diamino-6-quinazo...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	27	n/a	n/a	n/a	n/a	n/a	n/a
University of Alabama Curated by ChEMBL					Assay Description Inhibition of Trypanosoma cruzi DHFR by spectrophotometric assay				Bioorg Med Chem 18: 4056-66 (2010) Article DOI: 10.1016/j.bmc.2010.04.020 BindingDB Entry DOI: 10.7270/Q26110GG
University of Alabama Curated by ChEMBL					More data for this Ligand-Target Pair
Bifunctional dihydrofolate reductase-thymidylate synthase (Trypanosoma cruzi)	BDBM50320791 (6-[(3,4-Dimethoxyanilino)methyl]-2,4-quinazolinedi...) Show SMILES COc1ccc(NCc2ccc3nc(N)nc(N)c3c2)cc1OC Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	27.1	n/a	n/a	n/a	n/a	n/a	n/a
University of Alabama Curated by ChEMBL					Assay Description Inhibition of Trypanosoma cruzi DHFR by spectrophotometric assay				Bioorg Med Chem 18: 4056-66 (2010) Article DOI: 10.1016/j.bmc.2010.04.020 BindingDB Entry DOI: 10.7270/Q26110GG
University of Alabama Curated by ChEMBL					More data for this Ligand-Target Pair
Bifunctional dihydrofolate reductase-thymidylate synthase (Trypanosoma cruzi)	BDBM50320794 (CHEMBL1165306 \| Methyl4-[(5-[(2,4-diamino-6-quinaz...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	57.5	n/a	n/a	n/a	n/a	n/a	n/a
University of Alabama Curated by ChEMBL					Assay Description Inhibition of Trypanosoma cruzi DHFR by spectrophotometric assay				Bioorg Med Chem 18: 4056-66 (2010) Article DOI: 10.1016/j.bmc.2010.04.020 BindingDB Entry DOI: 10.7270/Q26110GG
University of Alabama Curated by ChEMBL					More data for this Ligand-Target Pair
Bifunctional dihydrofolate reductase-thymidylate synthase (Trypanosoma cruzi)	BDBM50320790 (4-(5-[(2,4-diamino-6-quinazolinyl)methyl]amino-2-m...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	61	n/a	n/a	n/a	n/a	n/a	n/a
University of Alabama Curated by ChEMBL					Assay Description Inhibition of Trypanosoma cruzi DHFR by spectrophotometric assay				Bioorg Med Chem 18: 4056-66 (2010) Article DOI: 10.1016/j.bmc.2010.04.020 BindingDB Entry DOI: 10.7270/Q26110GG
University of Alabama Curated by ChEMBL					More data for this Ligand-Target Pair
Dihydrofolate reductase (Homo sapiens (Human))	BDBM50320792 (CHEMBL1165388 \| Ethyl4-(5-[(2,4-diamino-6-quinazol...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	68.3	n/a	n/a	n/a	n/a	n/a	n/a
University of Alabama Curated by ChEMBL					Assay Description Inhibition of human DHFR by spectrophotometric assay				Bioorg Med Chem 18: 4056-66 (2010) Article DOI: 10.1016/j.bmc.2010.04.020 BindingDB Entry DOI: 10.7270/Q26110GG
University of Alabama Curated by ChEMBL					More data for this Ligand-Target Pair
Dihydrofolate reductase (Homo sapiens (Human))	BDBM18268 (5-methyl-6-{[(3,4,5-trimethoxyphenyl)amino]methyl}...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank Article PubMed	n/a	n/a	80.9	n/a	n/a	n/a	n/a	n/a	n/a
University of Alabama Curated by ChEMBL					Assay Description Inhibition of human DHFR by spectrophotometric assay				Bioorg Med Chem 18: 4056-66 (2010) Article DOI: 10.1016/j.bmc.2010.04.020 BindingDB Entry DOI: 10.7270/Q26110GG
University of Alabama Curated by ChEMBL					More data for this Ligand-Target Pair
Dihydrofolate reductase (Homo sapiens (Human))	BDBM50320791 (6-[(3,4-Dimethoxyanilino)methyl]-2,4-quinazolinedi...) Show SMILES COc1ccc(NCc2ccc3nc(N)nc(N)c3c2)cc1OC Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	85.5	n/a	n/a	n/a	n/a	n/a	n/a
University of Alabama Curated by ChEMBL					Assay Description Inhibition of human DHFR by spectrophotometric assay				Bioorg Med Chem 18: 4056-66 (2010) Article DOI: 10.1016/j.bmc.2010.04.020 BindingDB Entry DOI: 10.7270/Q26110GG
University of Alabama Curated by ChEMBL					More data for this Ligand-Target Pair
Dihydrofolate reductase (Homo sapiens (Human))	BDBM50320793 (CHEMBL1165305 \| Methyl5-(5-[(2,4-diamino-6-quinazo...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	93.5	n/a	n/a	n/a	n/a	n/a	n/a
University of Alabama Curated by ChEMBL					Assay Description Inhibition of human DHFR by spectrophotometric assay				Bioorg Med Chem 18: 4056-66 (2010) Article DOI: 10.1016/j.bmc.2010.04.020 BindingDB Entry DOI: 10.7270/Q26110GG
University of Alabama Curated by ChEMBL					More data for this Ligand-Target Pair
Dihydrofolate reductase (Homo sapiens (Human))	BDBM50320794 (CHEMBL1165306 \| Methyl4-[(5-[(2,4-diamino-6-quinaz...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	175	n/a	n/a	n/a	n/a	n/a	n/a
University of Alabama Curated by ChEMBL					Assay Description Inhibition of human DHFR by spectrophotometric assay				Bioorg Med Chem 18: 4056-66 (2010) Article DOI: 10.1016/j.bmc.2010.04.020 BindingDB Entry DOI: 10.7270/Q26110GG
University of Alabama Curated by ChEMBL					More data for this Ligand-Target Pair
Dihydrofolate reductase (Homo sapiens (Human))	BDBM50320790 (4-(5-[(2,4-diamino-6-quinazolinyl)methyl]amino-2-m...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	357	n/a	n/a	n/a	n/a	n/a	n/a
University of Alabama Curated by ChEMBL					Assay Description Inhibition of human DHFR by spectrophotometric assay				Bioorg Med Chem 18: 4056-66 (2010) Article DOI: 10.1016/j.bmc.2010.04.020 BindingDB Entry DOI: 10.7270/Q26110GG
University of Alabama Curated by ChEMBL					More data for this Ligand-Target Pair
Bifunctional dihydrofolate reductase-thymidylate synthase (Trypanosoma cruzi)	BDBM50320789 (CHEMBL1164234 \| methyl5-{5-[[(2,4-diamino-6-quinaz...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	422	n/a	n/a	n/a	n/a	n/a	n/a
University of Alabama Curated by ChEMBL					Assay Description Inhibition of Trypanosoma cruzi DHFR by spectrophotometric assay				Bioorg Med Chem 18: 4056-66 (2010) Article DOI: 10.1016/j.bmc.2010.04.020 BindingDB Entry DOI: 10.7270/Q26110GG
University of Alabama Curated by ChEMBL					More data for this Ligand-Target Pair
NH(3)-dependent NAD(+) synthetase (Bacillus subtilis)	BDBM50370232 (BA-41166E \| L-5103 \| RIFAMPIN \| Rifadin \| Rifampic...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase DrugBank MCE KEGG PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Alabama at Birmingham Curated by ChEMBL					Assay Description Inhibitory activity against Bacillus subtilis NAD synthetase				J Med Chem 46: 3371-81 (2003) Article DOI: 10.1021/jm030003x BindingDB Entry DOI: 10.7270/Q25T3M6Q
University of Alabama at Birmingham Curated by ChEMBL					More data for this Ligand-Target Pair
NH(3)-dependent NAD(+) synthetase (Bacillus subtilis)	BDBM50366389 (GENTAMICIN) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Alabama at Birmingham Curated by ChEMBL					Assay Description Inhibitory activity against Bacillus subtilis NAD synthetase				J Med Chem 46: 3371-81 (2003) Article DOI: 10.1021/jm030003x BindingDB Entry DOI: 10.7270/Q25T3M6Q
University of Alabama at Birmingham Curated by ChEMBL					More data for this Ligand-Target Pair
NH(3)-dependent NAD(+) synthetase (Bacillus subtilis)	BDBM18069 (5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-d...) Show SMILES COc1cc(Cc2cnc(N)nc2N)cc(OC)c1OC Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Alabama at Birmingham Curated by ChEMBL					Assay Description Inhibitory activity against Bacillus subtilis NAD synthetase				J Med Chem 46: 3371-81 (2003) Article DOI: 10.1021/jm030003x BindingDB Entry DOI: 10.7270/Q25T3M6Q
University of Alabama at Birmingham Curated by ChEMBL					More data for this Ligand-Target Pair
NH(3)-dependent NAD(+) synthetase (Bacillus subtilis)	BDBM50130829 (CHEMBL1164 \| Dimocillin sodium \| Meticillin sodium...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Alabama at Birmingham Curated by ChEMBL					Assay Description Inhibitory activity against Bacillus subtilis NAD synthetase				J Med Chem 46: 3371-81 (2003) Article DOI: 10.1021/jm030003x BindingDB Entry DOI: 10.7270/Q25T3M6Q
University of Alabama at Birmingham Curated by ChEMBL					More data for this Ligand-Target Pair
Dihydrofolate reductase (Homo sapiens (Human))	BDBM50320789 (CHEMBL1164234 \| methyl5-{5-[[(2,4-diamino-6-quinaz...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.34E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Alabama Curated by ChEMBL					Assay Description Inhibition of human DHFR by spectrophotometric assay				Bioorg Med Chem 18: 4056-66 (2010) Article DOI: 10.1016/j.bmc.2010.04.020 BindingDB Entry DOI: 10.7270/Q26110GG
University of Alabama Curated by ChEMBL					More data for this Ligand-Target Pair
Biofilm regulatory protein A (Streptococcus mutans serotype c (strain ATCC 70061...)	BDBM643909 (US11866416, Compound SN-I-238D \| US11866416, Compo...) Show SMILES Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	2.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
TBA					More data for this Ligand-Target Pair
Biofilm regulatory protein A (Streptococcus mutans serotype c (strain ATCC 70061...)	BDBM643909 (US11866416, Compound SN-I-238D \| US11866416, Compo...) Show SMILES Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	2.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
TBA					More data for this Ligand-Target Pair
Biofilm regulatory protein A (Streptococcus mutans serotype c (strain ATCC 70061...)	BDBM644003 (US11866416, Compound SN-II-50) Show SMILES Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	4.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
TBA					More data for this Ligand-Target Pair
Sodium channel protein type 5 subunit alpha (Homo sapiens (Human))	BDBM50461651 (CHEMBL4226210) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	4.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Alabama at Birmingham Curated by ChEMBL					Assay Description Inhibition of neonatal Nav1.5 in human MDA-MB-231 cells assessed as reduction in inward sodium peak current at -100 mV holding potential after 5 to 1...				Bioorg Med Chem 26: 2428-2436 (2018) Article DOI: 10.1016/j.bmc.2018.04.003 BindingDB Entry DOI: 10.7270/Q2MP55X5
University of Alabama at Birmingham Curated by ChEMBL					More data for this Ligand-Target Pair
Biofilm regulatory protein A (Streptococcus mutans serotype c (strain ATCC 70061...)	BDBM644015 (US11866416, Compound SN-II-105) Show SMILES COC(=O)c1cccc(NC(=O)c2cc3cc(N)ccc3o2)c1 Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	5.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
TBA					More data for this Ligand-Target Pair
Sodium channel protein type 5 subunit alpha (Homo sapiens (Human))	BDBM50461652 (CHEMBL4229014) Show SMILES Fc1ccc(CCCCNCCCN2CCCCC2)cc1 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	5.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Alabama at Birmingham Curated by ChEMBL					Assay Description Inhibition of neonatal Nav1.5 in human MDA-MB-231 cells assessed as reduction in inward sodium peak current at -100 mV holding potential after 5 to 1...				Bioorg Med Chem 26: 2428-2436 (2018) Article DOI: 10.1016/j.bmc.2018.04.003 BindingDB Entry DOI: 10.7270/Q2MP55X5
University of Alabama at Birmingham Curated by ChEMBL					More data for this Ligand-Target Pair
Biofilm regulatory protein A (Streptococcus mutans serotype c (strain ATCC 70061...)	BDBM644024 (US11866416, Compound LC-I-205) Show SMILES COc1cc(OC)c(\C=C2/Oc3ccccc3C2=O)cc1CO Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	8.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
TBA					More data for this Ligand-Target Pair
Biofilm regulatory protein A (Streptococcus mutans serotype c (strain ATCC 70061...)	BDBM644024 (US11866416, Compound LC-I-205) Show SMILES COc1cc(OC)c(\C=C2/Oc3ccccc3C2=O)cc1CO Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	8.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
TBA					More data for this Ligand-Target Pair
Biofilm regulatory protein A (Streptococcus mutans serotype c (strain ATCC 70061...)	BDBM50036936 (3'',4''-Dimethoxy-Aurone \| 3',4'-DIMETHOXY-AURONE ...) Show SMILES COc1ccc(\C=C2/Oc3ccccc3C2=O)cc1OC Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars		n/a	n/a	8.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
TBA					More data for this Ligand-Target Pair
Biofilm regulatory protein A (Streptococcus mutans serotype c (strain ATCC 70061...)	BDBM50036936 (3'',4''-Dimethoxy-Aurone \| 3',4'-DIMETHOXY-AURONE ...) Show SMILES COc1ccc(\C=C2/Oc3ccccc3C2=O)cc1OC Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars		n/a	n/a	8.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
TBA					More data for this Ligand-Target Pair
Biofilm regulatory protein A (Streptococcus mutans serotype c (strain ATCC 70061...)	BDBM643896 (US11866416, Compound SN-I-225C \| US11866416, Compo...) Show SMILES NC(=O)c1cccc(NC(=O)c2cnc3ccccc3c2)c1 Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	8.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
TBA					More data for this Ligand-Target Pair
Biofilm regulatory protein A (Streptococcus mutans serotype c (strain ATCC 70061...)	BDBM643896 (US11866416, Compound SN-I-225C \| US11866416, Compo...) Show SMILES NC(=O)c1cccc(NC(=O)c2cnc3ccccc3c2)c1 Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	8.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
TBA					More data for this Ligand-Target Pair
NH(3)-dependent NAD(+) synthetase (Bacillus subtilis)	BDBM92599 (CHEMBL263057 \| NAD Synthetase Inhibitor, 4) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Alabama at Birmingham Curated by ChEMBL					Assay Description Inhibitory activity against Bacillus subtilis NAD synthetase				J Med Chem 46: 3371-81 (2003) Article DOI: 10.1021/jm030003x BindingDB Entry DOI: 10.7270/Q25T3M6Q
University of Alabama at Birmingham Curated by ChEMBL					More data for this Ligand-Target Pair
Biofilm regulatory protein A (Streptococcus mutans serotype c (strain ATCC 70061...)	BDBM644013 (US11866416, Compound SN-II-81Cl \| US11866416, Comp...) Show SMILES Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	9.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
TBA					More data for this Ligand-Target Pair
Biofilm regulatory protein A (Streptococcus mutans serotype c (strain ATCC 70061...)	BDBM643893 (US11866416, Compound SN-I-217) Show SMILES Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	9.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
TBA					More data for this Ligand-Target Pair
Biofilm regulatory protein A (Streptococcus mutans serotype c (strain ATCC 70061...)	BDBM643893 (US11866416, Compound SN-I-217) Show SMILES Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	9.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
TBA					More data for this Ligand-Target Pair
Biofilm regulatory protein A (Streptococcus mutans serotype c (strain ATCC 70061...)	BDBM643893 (US11866416, Compound SN-I-217) Show SMILES Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	9.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
TBA					More data for this Ligand-Target Pair

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