Compile Data Set for Download or QSAR

Found 534 hits with Last Name = 'wall' and Initial = 'mj'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Macrophage colony-stimulating factor 1 receptor (Homo sapiens (Human))	BDBM50377072 (CHEMBL438533) Show SMILES CC1CCN(CC1)c1cc(ccc1NC(=O)c1ccc(o1)C#N)C1CCNCC1 Show InChI InChI=1S/C23H28N4O2/c1-16-8-12-27(13-9-16)21-14-18(17-6-10-25-11-7-17)2-4-20(21)26-23(28)22-5-3-19(15-24)29-22/h2-5,14,16-17,25H,6-13H2,1H3,(H,26,28)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a	n/a
Johnson& Johnson Pharmaceutical Research& Development Curated by ChEMBL					Assay Description Inhibition of FMS mediated phosphorylation using SYEGNSYTFIDPTQ as substrate after 80 mins by fluorescence polarization				J Med Chem 54: 7860-83 (2011) Article DOI: 10.1021/jm200900q BindingDB Entry DOI: 10.7270/Q2VD70JB
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (Homo sapiens (Human))	BDBM50321368 (4-cyano-N-(4-(1,3-dimethyl-2-oxohexahydropyrimidin...) Show SMILES CN1CC(CN(C)C1=O)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCC(C)(C)CC1 |t:28| Show InChI InChI=1S/C25H30N6O2/c1-25(2)9-7-16(8-10-25)20-11-17(18-14-30(3)24(33)31(4)15-18)5-6-21(20)29-23(32)22-27-13-19(12-26)28-22/h5-7,11,13,18H,8-10,14-15H2,1-4H3,(H,27,28)(H,29,32)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a	n/a
Johnson& Johnson Pharmaceutical Research& Development Curated by ChEMBL					Assay Description Inhibition of human FMS by fluorescence polarization				Bioorg Med Chem Lett 20: 3925-9 (2010) Article DOI: 10.1016/j.bmcl.2010.05.013 BindingDB Entry DOI: 10.7270/Q22Z16HG
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (Homo sapiens (Human))	BDBM50377072 (CHEMBL438533) Show SMILES CC1CCN(CC1)c1cc(ccc1NC(=O)c1ccc(o1)C#N)C1CCNCC1 Show InChI InChI=1S/C23H28N4O2/c1-16-8-12-27(13-9-16)21-14-18(17-6-10-25-11-7-17)2-4-20(21)26-23(28)22-5-3-19(15-24)29-22/h2-5,14,16-17,25H,6-13H2,1H3,(H,26,28)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a	n/a
Johnson& Johnson Pharmaceutical Research& Development Curated by ChEMBL					Assay Description Inhibition of FMS				Bioorg Med Chem Lett 18: 3632-7 (2008) Article DOI: 10.1016/j.bmcl.2008.04.059 BindingDB Entry DOI: 10.7270/Q2FN173T
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (Homo sapiens (Human))	BDBM50321373 (4-cyano-N-(4-(2-(cyanoimino)-1,3-dimethylhexahydro...) Show SMILES CN1CC(CN(C)C1=NC#N)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCC(C)(C)CC1 |t:30| Show InChI InChI=1S/C26H30N8O/c1-26(2)9-7-17(8-10-26)21-11-18(19-14-33(3)25(30-16-28)34(4)15-19)5-6-22(21)32-24(35)23-29-13-20(12-27)31-23/h5-7,11,13,19H,8-10,14-15H2,1-4H3,(H,29,31)(H,32,35)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
Johnson& Johnson Pharmaceutical Research& Development Curated by ChEMBL					Assay Description Inhibition of human FMS by fluorescence polarization				Bioorg Med Chem Lett 20: 3925-9 (2010) Article DOI: 10.1016/j.bmcl.2010.05.013 BindingDB Entry DOI: 10.7270/Q22Z16HG
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (Homo sapiens (Human))	BDBM50377071 (CHEMBL402337) Show SMILES CC1CCC(=CC1)c1cc(ccc1NC(=O)c1ncc([nH]1)C#N)C1CCNCC1 |c:4| Show InChI InChI=1S/C23H27N5O/c1-15-2-4-17(5-3-15)20-12-18(16-8-10-25-11-9-16)6-7-21(20)28-23(29)22-26-14-19(13-24)27-22/h4,6-7,12,14-16,25H,2-3,5,8-11H2,1H3,(H,26,27)(H,28,29)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
Johnson& Johnson Pharmaceutical Research& Development Curated by ChEMBL					Assay Description Inhibition of FMS				Bioorg Med Chem Lett 18: 3632-7 (2008) Article DOI: 10.1016/j.bmcl.2008.04.059 BindingDB Entry DOI: 10.7270/Q2FN173T
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (Mus musculus (Mouse))	BDBM98644 (US8497376, 20) Show SMILES CC1(C)CCC(=CC1)c1nc(ccc1NC(=O)c1ncc([nH]1)C#N)C1C[C@@](C)(CO)O[C@@](C)(CO)C1 |r,c:5| Show InChI InChI=1S/C27H35N5O4/c1-25(2)9-7-17(8-10-25)22-21(32-24(35)23-29-14-19(13-28)30-23)6-5-20(31-22)18-11-26(3,15-33)36-27(4,12-18)16-34/h5-7,14,18,33-34H,8-12,15-16H2,1-4H3,(H,29,30)(H,32,35)/t18?,26-,27+	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.410	n/a	n/a	n/a	n/a	7.5	n/a
Janssen Pharmaceutica N.V. US Patent					Assay Description An autophosphorylation, fluroescence polarization competition immunoassay was used to determine the potency for c-fms inhibition.				US Patent US8497376 (2013) BindingDB Entry DOI: 10.7270/Q2RN36GW
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (Mus musculus (Mouse))	BDBM98627 (US8497376, 8) Show SMILES CC1(C)CCC(=CC1)c1cc(ccc1NC(=O)c1nc(c[nH]1)[N+]#[C-])[C@]1(O)C[C@@]2(CO)CC[C@@](CO)(C1)O2 |r,c:5| Show InChI InChI=1S/C28H34N4O5/c1-25(2)8-6-18(7-9-25)20-12-19(4-5-21(20)31-24(35)23-30-13-22(29-3)32-23)28(36)14-26(16-33)10-11-27(15-28,17-34)37-26/h4-6,12-13,33-34,36H,7-11,14-17H2,1-2H3,(H,30,32)(H,31,35)/t26-,27+,28+	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.420	n/a	n/a	n/a	n/a	7.5	n/a
Janssen Pharmaceutica N.V. US Patent					Assay Description An autophosphorylation, fluroescence polarization competition immunoassay was used to determine the potency for c-fms inhibition.				US Patent US8497376 (2013) BindingDB Entry DOI: 10.7270/Q2RN36GW
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (Mus musculus (Mouse))	BDBM98621 (US8497376, 2) Show SMILES CC1(C)CCC(=CC1)c1cc(ccc1NC(=O)c1ncc([nH]1)C#N)[C@]1(O)C[C@]2(CO)O[C@](CO)(C1)C=C2 |r,c:5,39| Show InChI InChI=1S/C28H32N4O5/c1-25(2)7-5-18(6-8-25)21-11-19(3-4-22(21)32-24(35)23-30-13-20(12-29)31-23)28(36)14-26(16-33)9-10-27(15-28,17-34)37-26/h3-5,9-11,13,33-34,36H,6-8,14-17H2,1-2H3,(H,30,31)(H,32,35)/t26-,27+,28+	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.430	n/a	n/a	n/a	n/a	7.5	n/a
Janssen Pharmaceutica N.V. US Patent					Assay Description An autophosphorylation, fluroescence polarization competition immunoassay was used to determine the potency for c-fms inhibition.				US Patent US8497376 (2013) BindingDB Entry DOI: 10.7270/Q2RN36GW
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (Mus musculus (Mouse))	BDBM98624 (US8497376, 5) Show SMILES CC1(C)CCC(=CC1)c1cc(ccc1NC(=O)c1ncc([nH]1)C#N)[C@H]1C[C@@]2(CO)CC[C@@](CO)(C1)O2 |r,c:5| Show InChI InChI=1S/C28H34N4O4/c1-26(2)7-5-18(6-8-26)22-11-19(20-12-27(16-33)9-10-28(13-20,17-34)36-27)3-4-23(22)32-25(35)24-30-15-21(14-29)31-24/h3-5,11,15,20,33-34H,6-10,12-13,16-17H2,1-2H3,(H,30,31)(H,32,35)/t20-,27+,28-	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.470	n/a	n/a	n/a	n/a	7.5	n/a
Janssen Pharmaceutica N.V. US Patent					Assay Description An autophosphorylation, fluroescence polarization competition immunoassay was used to determine the potency for c-fms inhibition.				US Patent US8497376 (2013) BindingDB Entry DOI: 10.7270/Q2RN36GW
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (Homo sapiens (Human))	BDBM50321367 (4-cyano-N-(2-cyclohexenyl-4-(1,3-dimethyl-2-oxohex...) Show SMILES CN1CC(CN(C)C1=O)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCCCC1 |t:28| Show InChI InChI=1S/C23H26N6O2/c1-28-13-17(14-29(2)23(28)31)16-8-9-20(19(10-16)15-6-4-3-5-7-15)27-22(30)21-25-12-18(11-24)26-21/h6,8-10,12,17H,3-5,7,13-14H2,1-2H3,(H,25,26)(H,27,30)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
Johnson& Johnson Pharmaceutical Research& Development Curated by ChEMBL					Assay Description Inhibition of human FMS by fluorescence polarization				Bioorg Med Chem Lett 20: 3925-9 (2010) Article DOI: 10.1016/j.bmcl.2010.05.013 BindingDB Entry DOI: 10.7270/Q22Z16HG
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (Homo sapiens (Human))	BDBM50321365 (4-cyano-N-(2-cyclohexenyl-4-(1-methyl-2,6-dioxopip...) Show SMILES CN1C(=O)CC(CC1=O)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCCCC1 |t:28| Show InChI InChI=1S/C23H23N5O3/c1-28-20(29)10-16(11-21(28)30)15-7-8-19(18(9-15)14-5-3-2-4-6-14)27-23(31)22-25-13-17(12-24)26-22/h5,7-9,13,16H,2-4,6,10-11H2,1H3,(H,25,26)(H,27,31)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
Johnson& Johnson Pharmaceutical Research& Development Curated by ChEMBL					Assay Description Inhibition of human FMS by fluorescence polarization				Bioorg Med Chem Lett 20: 3925-9 (2010) Article DOI: 10.1016/j.bmcl.2010.05.013 BindingDB Entry DOI: 10.7270/Q22Z16HG
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (Homo sapiens (Human))	BDBM50443154 (CHEMBL3085973 | US8674100, 147) Show SMILES COCCNCC(C)(C)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCC(C)(C)CC1 |t:27| Show InChI InChI=1S/C26H35N5O2/c1-25(2)10-8-18(9-11-25)21-14-19(26(3,4)17-28-12-13-33-5)6-7-22(21)31-24(32)23-29-16-20(15-27)30-23/h6-8,14,16,28H,9-13,17H2,1-5H3,(H,29,30)(H,31,32)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.600	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutical Research& Development LLC Curated by ChEMBL					Assay Description Inhibition of FMS (unknown origin)				Bioorg Med Chem Lett 23: 6363-9 (2013) Article DOI: 10.1016/j.bmcl.2013.09.061 BindingDB Entry DOI: 10.7270/Q2MP54RH
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (Homo sapiens (Human))	BDBM119049 (CHEMBL3086320 | US8674100, 20 | US8674100, 69) Show SMILES COCCNC(C)(C)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCC(C)(C)CC1 |t:26| Show InChI InChI=1S/C25H33N5O2/c1-24(2)10-8-17(9-11-24)20-14-18(25(3,4)28-12-13-32-5)6-7-21(20)30-23(31)22-27-16-19(15-26)29-22/h6-8,14,16,28H,9-13H2,1-5H3,(H,27,29)(H,30,31)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.600	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutical Research& Development LLC Curated by ChEMBL					Assay Description Inhibition of FMS (unknown origin)				Bioorg Med Chem Lett 23: 6363-9 (2013) Article DOI: 10.1016/j.bmcl.2013.09.061 BindingDB Entry DOI: 10.7270/Q2MP54RH
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (Homo sapiens (Human))	BDBM50233716 (5-cyano-N-(4-(4-(2-hydroxyethyl)piperazin-1-yl)-2-...) Show SMILES CC1CCN(CC1)c1cc(ccc1NC(=O)c1ccc(o1)C#N)N1CCN(CCO)CC1 Show InChI InChI=1S/C24H31N5O3/c1-18-6-8-29(9-7-18)22-16-19(28-12-10-27(11-13-28)14-15-30)2-4-21(22)26-24(31)23-5-3-20(17-25)32-23/h2-5,16,18,30H,6-15H2,1H3,(H,26,31)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	0.600	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research & Development Curated by ChEMBL					Assay Description Inhibition of human cytoplasmic FMS expressed in Sf9-baculovirus system after 80 mins by fluorescence polarization				Bioorg Med Chem Lett 18: 1642-8 (2008) Article DOI: 10.1016/j.bmcl.2008.01.059 BindingDB Entry DOI: 10.7270/Q2FB52PS
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (Homo sapiens (Human))	BDBM50393560 (CHEMBL2158300 | US8697716, 48) Show SMILES CC(C)(N)CC(=O)N1CCC(CC1)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCCCC1 |t:32| Show InChI InChI=1S/C27H34N6O2/c1-27(2,29)15-24(34)33-12-10-18(11-13-33)20-8-9-23(22(14-20)19-6-4-3-5-7-19)32-26(35)25-30-17-21(16-28)31-25/h6,8-9,14,17-18H,3-5,7,10-13,15,29H2,1-2H3,(H,30,31)(H,32,35)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.620	n/a	n/a	n/a	n/a	n/a	n/a
Johnson& Johnson Pharmaceutical Research& Development Curated by ChEMBL					Assay Description Inhibition of FMS mediated phosphorylation using SYEGNSYTFIDPTQ as substrate after 80 mins by fluorescence polarization				J Med Chem 54: 7860-83 (2011) Article DOI: 10.1021/jm200900q BindingDB Entry DOI: 10.7270/Q2VD70JB
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (Mus musculus (Mouse))	BDBM50393549 (CHEMBL2158289) Show SMILES CN(CCO)CC(=O)N1CCC(CC1)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCCCC1 |t:33| Show InChI InChI=1S/C27H34N6O3/c1-32(13-14-34)18-25(35)33-11-9-19(10-12-33)21-7-8-24(23(15-21)20-5-3-2-4-6-20)31-27(36)26-29-17-22(16-28)30-26/h5,7-8,15,17,19,34H,2-4,6,9-14,18H2,1H3,(H,29,30)(H,31,36)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.640	n/a	n/a	n/a	n/a	n/a	n/a
Johnson& Johnson Pharmaceutical Research& Development Curated by ChEMBL					Assay Description Inhibition of FMS-mediated proliferation in CSF1-stimulated bone marrow-derived mouse macrophages assessed as inhibition of incorporation of bromodeo...				J Med Chem 54: 7860-83 (2011) Article DOI: 10.1021/jm200900q BindingDB Entry DOI: 10.7270/Q2VD70JB
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (Mus musculus (Mouse))	BDBM98622 (US8497376, 3) Show SMILES CC1(C)CCC(=CC1)c1cc(ccc1NC(=O)c1ncc([nH]1)C#N)C1=C[C@]2(CO)O[C@](CO)(C1)C=C2 |r,c:5,38,t:27| Show InChI InChI=1S/C28H30N4O4/c1-26(2)7-5-18(6-8-26)22-11-19(20-12-27(16-33)9-10-28(13-20,17-34)36-27)3-4-23(22)32-25(35)24-30-15-21(14-29)31-24/h3-5,9-12,15,33-34H,6-8,13,16-17H2,1-2H3,(H,30,31)(H,32,35)/t27-,28+/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.650	n/a	n/a	n/a	n/a	7.5	n/a
Janssen Pharmaceutica N.V. US Patent					Assay Description An autophosphorylation, fluroescence polarization competition immunoassay was used to determine the potency for c-fms inhibition.				US Patent US8497376 (2013) BindingDB Entry DOI: 10.7270/Q2RN36GW
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (Mus musculus (Mouse))	BDBM98648 (US8497376, 27) Show SMILES CC1(C)CCC(=CC1)c1cc(ccc1NC(=O)c1ncc([nH]1)C#N)[C@@]1(O)CC2O[C@@H](C1)C=C2 |r,c:5,35| Show InChI InChI=1S/C26H28N4O3/c1-25(2)9-7-16(8-10-25)21-11-17(26(32)12-19-4-5-20(13-26)33-19)3-6-22(21)30-24(31)23-28-15-18(14-27)29-23/h3-7,11,15,19-20,32H,8-10,12-13H2,1-2H3,(H,28,29)(H,30,31)/t19-,20?,26+/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.660	n/a	n/a	n/a	n/a	7.5	n/a
Janssen Pharmaceutica N.V. US Patent					Assay Description An autophosphorylation, fluroescence polarization competition immunoassay was used to determine the potency for c-fms inhibition.				US Patent US8497376 (2013) BindingDB Entry DOI: 10.7270/Q2RN36GW
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (Mus musculus (Mouse))	BDBM98631 (US8497376, 12) Show SMILES C[C@@]12C[C@](O)(C[C@@](C)(O1)[C@@H](O)[C@H]2O)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCC(C)(C)CC1 |r,t:33| Show InChI InChI=1S/C28H34N4O5/c1-25(2)9-7-16(8-10-25)19-11-17(5-6-20(19)32-24(35)23-30-13-18(12-29)31-23)28(36)14-26(3)21(33)22(34)27(4,15-28)37-26/h5-7,11,13,21-22,33-34,36H,8-10,14-15H2,1-4H3,(H,30,31)(H,32,35)/t21-,22+,26+,27-,28+	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.660	n/a	n/a	n/a	n/a	7.5	n/a
Janssen Pharmaceutica N.V. US Patent					Assay Description An autophosphorylation, fluroescence polarization competition immunoassay was used to determine the potency for c-fms inhibition.				US Patent US8497376 (2013) BindingDB Entry DOI: 10.7270/Q2RN36GW
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (Homo sapiens (Human))	BDBM50355499 (CHEMBL1908395 | CHEMBL1908842) Show SMILES CN(C)CC(=O)N1CCC(CC1)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCCCC1 |t:31| Show InChI InChI=1S/C26H32N6O2/c1-31(2)17-24(33)32-12-10-18(11-13-32)20-8-9-23(22(14-20)19-6-4-3-5-7-19)30-26(34)25-28-16-21(15-27)29-25/h6,8-9,14,16,18H,3-5,7,10-13,17H2,1-2H3,(H,28,29)(H,30,34)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.690	n/a	n/a	n/a	n/a	n/a	n/a
Johnson& Johnson Pharmaceutical Research& Development Curated by ChEMBL					Assay Description Inhibition of FMS mediated phosphorylation using SYEGNSYTFIDPTQ as substrate after 80 mins by fluorescence polarization				J Med Chem 54: 7860-83 (2011) Article DOI: 10.1021/jm200900q BindingDB Entry DOI: 10.7270/Q2VD70JB
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (Homo sapiens (Human))	BDBM50355499 (CHEMBL1908395 | CHEMBL1908842) Show SMILES CN(C)CC(=O)N1CCC(CC1)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCCCC1 |t:31| Show InChI InChI=1S/C26H32N6O2/c1-31(2)17-24(33)32-12-10-18(11-13-32)20-8-9-23(22(14-20)19-6-4-3-5-7-19)30-26(34)25-28-16-21(15-27)29-25/h6,8-9,14,16,18H,3-5,7,10-13,17H2,1-2H3,(H,28,29)(H,30,34)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.690	n/a	n/a	n/a	n/a	n/a	n/a
Johnson& Johnson Pharmaceutical Research& Development Curated by ChEMBL					Assay Description Inhibition of FMS				J Med Chem 54: 7860-83 (2011) Article DOI: 10.1021/jm200900q BindingDB Entry DOI: 10.7270/Q2VD70JB
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (Homo sapiens (Human))	BDBM50233701 (5-cyano-furan-2-carboxylic acid [4-(1,1-dioxo-1lam...) Show SMILES O=C(Nc1ccc(cc1N1CCCCC1)N1CCS(=O)(=O)CC1)c1ccc(o1)C#N Show InChI InChI=1S/C21H24N4O4S/c22-15-17-5-7-20(29-17)21(26)23-18-6-4-16(24-10-12-30(27,28)13-11-24)14-19(18)25-8-2-1-3-9-25/h4-7,14H,1-3,8-13H2,(H,23,26)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	0.700	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research & Development Curated by ChEMBL					Assay Description Inhibition of human cytoplasmic FMS expressed in Sf9-baculovirus system after 80 mins by fluorescence polarization				Bioorg Med Chem Lett 18: 1642-8 (2008) Article DOI: 10.1016/j.bmcl.2008.01.059 BindingDB Entry DOI: 10.7270/Q2FB52PS
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (Homo sapiens (Human))	BDBM50393562 (CHEMBL2158302) Show SMILES OCCNC(=O)N1CCC(CC1)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCCCC1 |t:31| Show InChI InChI=1S/C25H30N6O3/c26-15-20-16-28-23(29-20)24(33)30-22-7-6-19(14-21(22)18-4-2-1-3-5-18)17-8-11-31(12-9-17)25(34)27-10-13-32/h4,6-7,14,16-17,32H,1-3,5,8-13H2,(H,27,34)(H,28,29)(H,30,33)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.700	n/a	n/a	n/a	n/a	n/a	n/a
Johnson& Johnson Pharmaceutical Research& Development Curated by ChEMBL					Assay Description Inhibition of FMS mediated phosphorylation using SYEGNSYTFIDPTQ as substrate after 80 mins by fluorescence polarization				J Med Chem 54: 7860-83 (2011) Article DOI: 10.1021/jm200900q BindingDB Entry DOI: 10.7270/Q2VD70JB
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (Homo sapiens (Human))	BDBM50233720 (CHEMBL254909 | N-(4-(4-acetylpiperazin-1-yl)-2-(4-...) Show SMILES CC1CCN(CC1)c1cc(ccc1NC(=O)c1cc(c[nH]1)C#N)N1CCN(CC1)C(C)=O Show InChI InChI=1S/C24H30N6O2/c1-17-5-7-30(8-6-17)23-14-20(29-11-9-28(10-12-29)18(2)31)3-4-21(23)27-24(32)22-13-19(15-25)16-26-22/h3-4,13-14,16-17,26H,5-12H2,1-2H3,(H,27,32)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	0.700	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research & Development Curated by ChEMBL					Assay Description Inhibition of human cytoplasmic FMS expressed in Sf9-baculovirus system after 80 mins by fluorescence polarization				Bioorg Med Chem Lett 18: 1642-8 (2008) Article DOI: 10.1016/j.bmcl.2008.01.059 BindingDB Entry DOI: 10.7270/Q2FB52PS
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (Homo sapiens (Human))	BDBM50443167 (CHEMBL3085977 | US8674100, 76) Show SMILES CC(=O)NCCNC(C)(C)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCC(C)(C)CC1 |t:28| Show InChI InChI=1S/C26H34N6O2/c1-17(33)28-12-13-30-26(4,5)19-6-7-22(32-24(34)23-29-16-20(15-27)31-23)21(14-19)18-8-10-25(2,3)11-9-18/h6-8,14,16,30H,9-13H2,1-5H3,(H,28,33)(H,29,31)(H,32,34)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.700	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutical Research& Development LLC Curated by ChEMBL					Assay Description Inhibition of FMS (unknown origin)				Bioorg Med Chem Lett 23: 6363-9 (2013) Article DOI: 10.1016/j.bmcl.2013.09.061 BindingDB Entry DOI: 10.7270/Q2MP54RH
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (Homo sapiens (Human))	BDBM119044 (CHEMBL3085833 | US8674100, 62 | US8674100, 63) Show SMILES CC(C)(N1CCN(CCO)CC1)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCC(C)(C)CC1 |t:31| Show InChI InChI=1S/C28H38N6O2/c1-27(2)9-7-20(8-10-27)23-17-21(28(3,4)34-13-11-33(12-14-34)15-16-35)5-6-24(23)32-26(36)25-30-19-22(18-29)31-25/h5-7,17,19,35H,8-16H2,1-4H3,(H,30,31)(H,32,36)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.700	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutical Research& Development LLC Curated by ChEMBL					Assay Description Inhibition of FMS (unknown origin)				Bioorg Med Chem Lett 23: 6363-9 (2013) Article DOI: 10.1016/j.bmcl.2013.09.061 BindingDB Entry DOI: 10.7270/Q2MP54RH
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (Mus musculus (Mouse))	BDBM98642 (US8497376, 18) Show SMILES C[C@@]12CC(C[C@@](C)(O1)[C@@H](O)[C@H]2O)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(n1)C1=CCC(C)(C)CC1 |r,t:32| Show InChI InChI=1S/C27H33N5O4/c1-25(2)9-7-15(8-10-25)20-19(32-24(35)23-29-14-17(13-28)30-23)6-5-18(31-20)16-11-26(3)21(33)22(34)27(4,12-16)36-26/h5-7,14,16,21-22,33-34H,8-12H2,1-4H3,(H,29,30)(H,32,35)/t16?,21-,22+,26+,27-	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.720	n/a	n/a	n/a	n/a	7.5	n/a
Janssen Pharmaceutica N.V. US Patent					Assay Description An autophosphorylation, fluroescence polarization competition immunoassay was used to determine the potency for c-fms inhibition.				US Patent US8497376 (2013) BindingDB Entry DOI: 10.7270/Q2RN36GW
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (Mus musculus (Mouse))	BDBM98623 (US8497376, 4) Show SMILES CC1(C)CCC(=CC1)c1cc(ccc1NC(=O)c1ncc([nH]1)C#N)[C@@H]1C[C@@]2(CO)CC[C@@](CO)(C1)O2 |r,c:5| Show InChI InChI=1S/C28H34N4O4/c1-26(2)7-5-18(6-8-26)22-11-19(20-12-27(16-33)9-10-28(13-20,17-34)36-27)3-4-23(22)32-25(35)24-30-15-21(14-29)31-24/h3-5,11,15,20,33-34H,6-10,12-13,16-17H2,1-2H3,(H,30,31)(H,32,35)/t20-,27-,28+	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.720	n/a	n/a	n/a	n/a	7.5	n/a
Janssen Pharmaceutica N.V. US Patent					Assay Description An autophosphorylation, fluroescence polarization competition immunoassay was used to determine the potency for c-fms inhibition.				US Patent US8497376 (2013) BindingDB Entry DOI: 10.7270/Q2RN36GW
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (Homo sapiens (Human))	BDBM27917 (4-cyano-N-[4-(4-methylpiperazin-1-yl)-2-(4-methylp...) Show SMILES CC1CCN(CC1)c1cc(ccc1NC(=O)c1cc(c[nH]1)C#N)N1CCN(C)CC1 Show InChI InChI=1S/C23H30N6O/c1-17-5-7-29(8-6-17)22-14-19(28-11-9-27(2)10-12-28)3-4-20(22)26-23(30)21-13-18(15-24)16-25-21/h3-4,13-14,16-17,25H,5-12H2,1-2H3,(H,26,30)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	0.780	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research & Development Curated by ChEMBL					Assay Description Inhibition of human cytoplasmic FMS expressed in Sf9-baculovirus system after 80 mins by fluorescence polarization				Bioorg Med Chem Lett 18: 1642-8 (2008) Article DOI: 10.1016/j.bmcl.2008.01.059 BindingDB Entry DOI: 10.7270/Q2FB52PS
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (Homo sapiens (Human))	BDBM27917 (4-cyano-N-[4-(4-methylpiperazin-1-yl)-2-(4-methylp...) Show SMILES CC1CCN(CC1)c1cc(ccc1NC(=O)c1cc(c[nH]1)C#N)N1CCN(C)CC1 Show InChI InChI=1S/C23H30N6O/c1-17-5-7-29(8-6-17)22-14-19(28-11-9-27(2)10-12-28)3-4-20(22)26-23(30)21-13-18(15-24)16-25-21/h3-4,13-14,16-17,25H,5-12H2,1-2H3,(H,26,30)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	0.800	n/a	n/a	n/a	n/a	n/a	n/a
Johnson& Johnson Pharmaceutical Research& Development Curated by ChEMBL					Assay Description Inhibition of FMS mediated phosphorylation using SYEGNSYTFIDPTQ as substrate after 80 mins by fluorescence polarization				J Med Chem 54: 7860-83 (2011) Article DOI: 10.1021/jm200900q BindingDB Entry DOI: 10.7270/Q2VD70JB
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (Homo sapiens (Human))	BDBM50233715 (5-cyano-N-(4-(4-methylpiperazin-1-yl)-2-(piperidin...) Show SMILES CN1CCN(CC1)c1ccc(NC(=O)c2ccc(o2)C#N)c(c1)N1CCCCC1 Show InChI InChI=1S/C22H27N5O2/c1-25-11-13-26(14-12-25)17-5-7-19(20(15-17)27-9-3-2-4-10-27)24-22(28)21-8-6-18(16-23)29-21/h5-8,15H,2-4,9-14H2,1H3,(H,24,28)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	0.800	n/a	n/a	n/a	n/a	n/a	n/a
Johnson& Johnson Pharmaceutical Research& Development Curated by ChEMBL					Assay Description Inhibition of FMS mediated phosphorylation using SYEGNSYTFIDPTQ as substrate after 80 mins by fluorescence polarization				J Med Chem 54: 7860-83 (2011) Article DOI: 10.1021/jm200900q BindingDB Entry DOI: 10.7270/Q2VD70JB
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (Homo sapiens (Human))	BDBM50443140 (CHEMBL3085984 | US8674100, 150) Show SMILES CC1(C)CCC(=CC1)c1cc(CN2CCN(CCO)CC2)ccc1NC(=O)c1ncc([nH]1)C#N |c:5| Show InChI InChI=1S/C26H34N6O2/c1-26(2)7-5-20(6-8-26)22-15-19(18-32-11-9-31(10-12-32)13-14-33)3-4-23(22)30-25(34)24-28-17-21(16-27)29-24/h3-5,15,17,33H,6-14,18H2,1-2H3,(H,28,29)(H,30,34)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.800	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutical Research& Development LLC Curated by ChEMBL					Assay Description Inhibition of FMS (unknown origin)				Bioorg Med Chem Lett 23: 6363-9 (2013) Article DOI: 10.1016/j.bmcl.2013.09.061 BindingDB Entry DOI: 10.7270/Q2MP54RH
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (Homo sapiens (Human))	BDBM50233715 (5-cyano-N-(4-(4-methylpiperazin-1-yl)-2-(piperidin...) Show SMILES CN1CCN(CC1)c1ccc(NC(=O)c2ccc(o2)C#N)c(c1)N1CCCCC1 Show InChI InChI=1S/C22H27N5O2/c1-25-11-13-26(14-12-25)17-5-7-19(20(15-17)27-9-3-2-4-10-27)24-22(28)21-8-6-18(16-23)29-21/h5-8,15H,2-4,9-14H2,1H3,(H,24,28)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	0.800	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research & Development Curated by ChEMBL					Assay Description Inhibition of human cytoplasmic FMS expressed in Sf9-baculovirus system after 80 mins by fluorescence polarization				Bioorg Med Chem Lett 18: 1642-8 (2008) Article DOI: 10.1016/j.bmcl.2008.01.059 BindingDB Entry DOI: 10.7270/Q2FB52PS
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (Homo sapiens (Human))	BDBM50321364 (4-cyano-N-(2-(4,4-dimethylcyclohex-1-enyl)-4-(2,6-...) Show SMILES CC1(C)CCC(=CC1)c1cc(ccc1NC(=O)c1ncc([nH]1)C#N)C1CC(=O)NC(=O)C1 |c:5| Show InChI InChI=1S/C24H25N5O3/c1-24(2)7-5-14(6-8-24)18-9-15(16-10-20(30)29-21(31)11-16)3-4-19(18)28-23(32)22-26-13-17(12-25)27-22/h3-5,9,13,16H,6-8,10-11H2,1-2H3,(H,26,27)(H,28,32)(H,29,30,31)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	0.800	n/a	n/a	n/a	n/a	n/a	n/a
Johnson& Johnson Pharmaceutical Research& Development Curated by ChEMBL					Assay Description Inhibition of human FMS by fluorescence polarization				Bioorg Med Chem Lett 20: 3925-9 (2010) Article DOI: 10.1016/j.bmcl.2010.05.013 BindingDB Entry DOI: 10.7270/Q22Z16HG
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (Homo sapiens (Human))	BDBM50377060 (CHEMBL255443) Show SMILES CC1CCN(CC1)c1cc(ccc1NC(=O)c1ccc(o1)C#N)C1=CCNCC1 |t:26| Show InChI InChI=1S/C23H26N4O2/c1-16-8-12-27(13-9-16)21-14-18(17-6-10-25-11-7-17)2-4-20(21)26-23(28)22-5-3-19(15-24)29-22/h2-6,14,16,25H,7-13H2,1H3,(H,26,28)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.800	n/a	n/a	n/a	n/a	n/a	n/a
Johnson& Johnson Pharmaceutical Research& Development Curated by ChEMBL					Assay Description Inhibition of FMS				Bioorg Med Chem Lett 18: 3632-7 (2008) Article DOI: 10.1016/j.bmcl.2008.04.059 BindingDB Entry DOI: 10.7270/Q2FN173T
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (Homo sapiens (Human))	BDBM27917 (4-cyano-N-[4-(4-methylpiperazin-1-yl)-2-(4-methylp...) Show SMILES CC1CCN(CC1)c1cc(ccc1NC(=O)c1cc(c[nH]1)C#N)N1CCN(C)CC1 Show InChI InChI=1S/C23H30N6O/c1-17-5-7-29(8-6-17)22-14-19(28-11-9-27(2)10-12-28)3-4-20(22)26-23(30)21-13-18(15-24)16-25-21/h3-4,13-14,16-17,25H,5-12H2,1-2H3,(H,26,30)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	0.800	n/a	n/a	n/a	n/a	n/a	n/a
Johnson& Johnson Pharmaceutical Research& Development Curated by ChEMBL					Assay Description Inhibition of FMS				Bioorg Med Chem Lett 18: 3632-7 (2008) Article DOI: 10.1016/j.bmcl.2008.04.059 BindingDB Entry DOI: 10.7270/Q2FN173T
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (Homo sapiens (Human))	BDBM50377059 (CHEMBL257620) Show SMILES CC1CCN(CC1)c1cc(ccc1NC(=O)c1ccc(o1)C#N)C1CCN(CC1)C(C)=O Show InChI InChI=1S/C25H30N4O3/c1-17-7-11-29(12-8-17)23-15-20(19-9-13-28(14-10-19)18(2)30)3-5-22(23)27-25(31)24-6-4-21(16-26)32-24/h3-6,15,17,19H,7-14H2,1-2H3,(H,27,31)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.800	n/a	n/a	n/a	n/a	n/a	n/a
Johnson& Johnson Pharmaceutical Research& Development Curated by ChEMBL					Assay Description Inhibition of FMS				Bioorg Med Chem Lett 18: 3632-7 (2008) Article DOI: 10.1016/j.bmcl.2008.04.059 BindingDB Entry DOI: 10.7270/Q2FN173T
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (Homo sapiens (Human))	BDBM119043 (CHEMBL3085978 | US8674100, 60 | US9221797, 60) Show SMILES CC1(C)CCC(=CC1)c1cc(CCN2CCOCC2)ccc1NC(=O)c1ncc([nH]1)C#N |c:5| Show InChI InChI=1S/C25H31N5O2/c1-25(2)8-5-19(6-9-25)21-15-18(7-10-30-11-13-32-14-12-30)3-4-22(21)29-24(31)23-27-17-20(16-26)28-23/h3-5,15,17H,6-14H2,1-2H3,(H,27,28)(H,29,31)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.800	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutical Research& Development LLC Curated by ChEMBL					Assay Description Inhibition of FMS (unknown origin)				Bioorg Med Chem Lett 23: 6363-9 (2013) Article DOI: 10.1016/j.bmcl.2013.09.061 BindingDB Entry DOI: 10.7270/Q2MP54RH
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (Mus musculus (Mouse))	BDBM98632 (US8497376, 13) Show SMILES C[C@@]12C[C@@H](C[C@@](C)(O1)[C@@H](O)[C@H]2O)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCC(C)(C)CC1 |r,t:32| Show InChI InChI=1S/C28H34N4O4/c1-26(2)9-7-16(8-10-26)20-11-17(18-12-27(3)22(33)23(34)28(4,13-18)36-27)5-6-21(20)32-25(35)24-30-15-19(14-29)31-24/h5-7,11,15,18,22-23,33-34H,8-10,12-13H2,1-4H3,(H,30,31)(H,32,35)/t18-,22+,23-,27-,28+	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.810	n/a	n/a	n/a	n/a	7.5	n/a
Janssen Pharmaceutica N.V. US Patent					Assay Description An autophosphorylation, fluroescence polarization competition immunoassay was used to determine the potency for c-fms inhibition.				US Patent US8497376 (2013) BindingDB Entry DOI: 10.7270/Q2RN36GW
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (Homo sapiens (Human))	BDBM50393548 (CHEMBL2158288) Show SMILES OCCNCC(=O)N1CCC(CC1)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCCCC1 |t:32| Show InChI InChI=1S/C26H32N6O3/c27-15-21-16-29-25(30-21)26(35)31-23-7-6-20(14-22(23)19-4-2-1-3-5-19)18-8-11-32(12-9-18)24(34)17-28-10-13-33/h4,6-7,14,16,18,28,33H,1-3,5,8-13,17H2,(H,29,30)(H,31,35)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.830	n/a	n/a	n/a	n/a	n/a	n/a
Johnson& Johnson Pharmaceutical Research& Development Curated by ChEMBL					Assay Description Inhibition of FMS mediated phosphorylation using SYEGNSYTFIDPTQ as substrate after 80 mins by fluorescence polarization				J Med Chem 54: 7860-83 (2011) Article DOI: 10.1021/jm200900q BindingDB Entry DOI: 10.7270/Q2VD70JB
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (Mus musculus (Mouse))	BDBM98620 (US8497376, 1) Show SMILES COC[C@@]12C[C@](O)(C[C@@](COC)(O1)C=C2)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCC(C)(C)CC1 |r,c:14,t:35| Show InChI InChI=1S/C30H36N4O5/c1-27(2)9-7-20(8-10-27)23-13-21(5-6-24(23)34-26(35)25-32-15-22(14-31)33-25)30(36)16-28(18-37-3)11-12-29(17-30,39-28)19-38-4/h5-7,11-13,15,36H,8-10,16-19H2,1-4H3,(H,32,33)(H,34,35)/t28-,29+,30+	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.860	n/a	n/a	n/a	n/a	7.5	n/a
Janssen Pharmaceutica N.V. US Patent					Assay Description An autophosphorylation, fluroescence polarization competition immunoassay was used to determine the potency for c-fms inhibition.				US Patent US8497376 (2013) BindingDB Entry DOI: 10.7270/Q2RN36GW
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (Homo sapiens (Human))	BDBM50233713 (5-cyano-N-(2-(4-methylpiperidin-1-yl)-4-(4-(methyl...) Show SMILES CC1CCN(CC1)c1cc(ccc1NC(=O)c1ccc(o1)C#N)N1CCN(CC1)S(C)(=O)=O Show InChI InChI=1S/C23H29N5O4S/c1-17-7-9-27(10-8-17)21-15-18(26-11-13-28(14-12-26)33(2,30)31)3-5-20(21)25-23(29)22-6-4-19(16-24)32-22/h3-6,15,17H,7-14H2,1-2H3,(H,25,29)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	0.900	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research & Development Curated by ChEMBL					Assay Description Inhibition of human cytoplasmic FMS expressed in Sf9-baculovirus system after 80 mins by fluorescence polarization				Bioorg Med Chem Lett 18: 1642-8 (2008) Article DOI: 10.1016/j.bmcl.2008.01.059 BindingDB Entry DOI: 10.7270/Q2FB52PS
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (Homo sapiens (Human))	BDBM50443165 (CHEMBL3085828 | US8674100, 22) Show SMILES CC(C)(N1CCOCC1)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCC(C)(C)CC1 |t:28| Show InChI InChI=1S/C26H33N5O2/c1-25(2)9-7-18(8-10-25)21-15-19(26(3,4)31-11-13-33-14-12-31)5-6-22(21)30-24(32)23-28-17-20(16-27)29-23/h5-7,15,17H,8-14H2,1-4H3,(H,28,29)(H,30,32)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.900	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutical Research& Development LLC Curated by ChEMBL					Assay Description Inhibition of FMS (unknown origin)				Bioorg Med Chem Lett 23: 6363-9 (2013) Article DOI: 10.1016/j.bmcl.2013.09.061 BindingDB Entry DOI: 10.7270/Q2MP54RH
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (Homo sapiens (Human))	BDBM50321369 (4-cyano-N-(2-cycloheptenyl-4-(1,3-dimethyl-2-oxohe...) Show SMILES CN1CC(CN(C)C1=O)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCCCCC1 |t:28| Show InChI InChI=1S/C24H28N6O2/c1-29-14-18(15-30(2)24(29)32)17-9-10-21(20(11-17)16-7-5-3-4-6-8-16)28-23(31)22-26-13-19(12-25)27-22/h7,9-11,13,18H,3-6,8,14-15H2,1-2H3,(H,26,27)(H,28,31)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	0.900	n/a	n/a	n/a	n/a	n/a	n/a
Johnson& Johnson Pharmaceutical Research& Development Curated by ChEMBL					Assay Description Inhibition of human FMS by fluorescence polarization				Bioorg Med Chem Lett 20: 3925-9 (2010) Article DOI: 10.1016/j.bmcl.2010.05.013 BindingDB Entry DOI: 10.7270/Q22Z16HG
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (Homo sapiens (Human))	BDBM50393549 (CHEMBL2158289) Show SMILES CN(CCO)CC(=O)N1CCC(CC1)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCCCC1 |t:33| Show InChI InChI=1S/C27H34N6O3/c1-32(13-14-34)18-25(35)33-11-9-19(10-12-33)21-7-8-24(23(15-21)20-5-3-2-4-6-20)31-27(36)26-29-17-22(16-28)30-26/h5,7-8,15,17,19,34H,2-4,6,9-14,18H2,1H3,(H,29,30)(H,31,36)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Johnson& Johnson Pharmaceutical Research& Development Curated by ChEMBL					Assay Description Inhibition of FMS mediated phosphorylation using SYEGNSYTFIDPTQ as substrate after 80 mins by fluorescence polarization				J Med Chem 54: 7860-83 (2011) Article DOI: 10.1021/jm200900q BindingDB Entry DOI: 10.7270/Q2VD70JB
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (Homo sapiens (Human))	BDBM50321363 (4-cyano-N-(2-cyclohexenyl-4-(2,6-dioxopiperidin-4-...) Show SMILES O=C(Nc1ccc(cc1C1=CCCCC1)C1CC(=O)NC(=O)C1)c1ncc([nH]1)C#N |t:10| Show InChI InChI=1S/C22H21N5O3/c23-11-16-12-24-21(25-16)22(30)26-18-7-6-14(15-9-19(28)27-20(29)10-15)8-17(18)13-4-2-1-3-5-13/h4,6-8,12,15H,1-3,5,9-10H2,(H,24,25)(H,26,30)(H,27,28,29)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Johnson& Johnson Pharmaceutical Research& Development Curated by ChEMBL					Assay Description Inhibition of human FMS by fluorescence polarization				Bioorg Med Chem Lett 20: 3925-9 (2010) Article DOI: 10.1016/j.bmcl.2010.05.013 BindingDB Entry DOI: 10.7270/Q22Z16HG
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (Homo sapiens (Human))	BDBM50377058 (CHEMBL2158221 | CHEMBL257154 | US8697716, 14) Show SMILES O=C(Nc1ccc(cc1C1=CCCCC1)C1CCNCC1)c1ncc([nH]1)C#N |t:10| Show InChI InChI=1S/C22H25N5O/c23-13-18-14-25-21(26-18)22(28)27-20-7-6-17(15-8-10-24-11-9-15)12-19(20)16-4-2-1-3-5-16/h4,6-7,12,14-15,24H,1-3,5,8-11H2,(H,25,26)(H,27,28)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Johnson& Johnson Pharmaceutical Research& Development Curated by ChEMBL					Assay Description Inhibition of FMS				Bioorg Med Chem Lett 18: 3632-7 (2008) Article DOI: 10.1016/j.bmcl.2008.04.059 BindingDB Entry DOI: 10.7270/Q2FN173T
					More data for this Ligand-Target Pair
Voltage-dependent N-type calcium channel subunit alpha-1B (Homo sapiens (Human))	BDBM50465788 (CHEMBL4292697) Show SMILES COc1ccccc1-n1nc(cc1-c1ccc(cc1)C#N)C1CC(C)(C)OC(C)(C)C1 Show InChI InChI=1S/C26H29N3O2/c1-25(2)15-20(16-26(3,4)31-25)21-14-23(19-12-10-18(17-27)11-13-19)29(28-21)22-8-6-7-9-24(22)30-5/h6-14,20H,15-16H2,1-5H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Research & Development, L.L.C. Curated by ChEMBL					Assay Description Inhibition of Cav2.2 (unknown origin) expressed in HEK293 cells assessed as decrease in KCl depolarization-induced Ca2+ influx measured for 5 mins by...				Bioorg Med Chem Lett 28: 3780-3783 (2018) Article DOI: 10.1016/j.bmcl.2018.10.007 BindingDB Entry DOI: 10.7270/Q2571FP9
					More data for this Ligand-Target Pair
Voltage-dependent N-type calcium channel subunit alpha-1B (Homo sapiens (Human))	BDBM50465792 (CHEMBL4279774) Show SMILES COc1ccccc1-n1nc(cc1-c1ccc(Cl)cc1)C1CC(C)(C)OC(C)(C)C1 Show InChI InChI=1S/C25H29ClN2O2/c1-24(2)15-18(16-25(3,4)30-24)20-14-22(17-10-12-19(26)13-11-17)28(27-20)21-8-6-7-9-23(21)29-5/h6-14,18H,15-16H2,1-5H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Research & Development, L.L.C. Curated by ChEMBL					Assay Description Inhibition of Cav2.2 (unknown origin) expressed in HEK293 cells assessed as decrease in KCl depolarization-induced Ca2+ influx measured for 5 mins by...				Bioorg Med Chem Lett 28: 3780-3783 (2018) Article DOI: 10.1016/j.bmcl.2018.10.007 BindingDB Entry DOI: 10.7270/Q2571FP9
					More data for this Ligand-Target Pair				3D Structure (crystal)
Macrophage colony-stimulating factor 1 receptor (Homo sapiens (Human))	BDBM50233707 (5-cyano-N-(4-(4-methylpiperazin-1-yl)-2-(4-methylp...) Show SMILES CC1CCN(CC1)c1cc(ccc1NC(=O)c1ccc(o1)C#N)N1CCN(C)CC1 Show InChI InChI=1S/C23H29N5O2/c1-17-7-9-28(10-8-17)21-15-18(27-13-11-26(2)12-14-27)3-5-20(21)25-23(29)22-6-4-19(16-24)30-22/h3-6,15,17H,7-14H2,1-2H3,(H,25,29)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Johnson& Johnson Pharmaceutical Research& Development Curated by ChEMBL					Assay Description Inhibition of FMS mediated phosphorylation using SYEGNSYTFIDPTQ as substrate after 80 mins by fluorescence polarization				J Med Chem 54: 7860-83 (2011) Article DOI: 10.1021/jm200900q BindingDB Entry DOI: 10.7270/Q2VD70JB
					More data for this Ligand-Target Pair

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