Found 35 hits with Last Name = 'wardle' and Initial = 'ka' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
5-hydroxytryptamine receptor 2C
(PIG) | BDBM82505
(CAS_121881 | NSC_121881 | SB204070)Show InChI InChI=1S/C19H27ClN2O4/c1-2-3-6-22-7-4-13(5-8-22)12-26-19(23)14-11-15(20)16(21)18-17(14)24-9-10-25-18/h11,13H,2-10,12,21H2,1H3 | PDB
Reactome pathway
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| 126 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals
Curated by PDSP Ki Database
| |
Br J Pharmacol 112: 789-94 (1994)
Article DOI: 10.1111/j.1476-5381.1994.tb13148.x
BindingDB Entry DOI: 10.7270/Q2N0151D |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 3A
(RAT) | BDBM82505
(CAS_121881 | NSC_121881 | SB204070)Show InChI InChI=1S/C19H27ClN2O4/c1-2-3-6-22-7-4-13(5-8-22)12-26-19(23)14-11-15(20)16(21)18-17(14)24-9-10-25-18/h11,13H,2-10,12,21H2,1H3 | PDB
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| 398 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals
Curated by PDSP Ki Database
| |
Br J Pharmacol 112: 789-94 (1994)
Article DOI: 10.1111/j.1476-5381.1994.tb13148.x
BindingDB Entry DOI: 10.7270/Q2N0151D |
More data for this
Ligand-Target Pair | |
Beta-2 adrenergic receptor
(Homo sapiens (Human)) | BDBM82505
(CAS_121881 | NSC_121881 | SB204070)Show InChI InChI=1S/C19H27ClN2O4/c1-2-3-6-22-7-4-13(5-8-22)12-26-19(23)14-11-15(20)16(21)18-17(14)24-9-10-25-18/h11,13H,2-10,12,21H2,1H3 | PDB
MMDB
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| 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals
Curated by PDSP Ki Database
| |
Br J Pharmacol 112: 789-94 (1994)
Article DOI: 10.1111/j.1476-5381.1994.tb13148.x
BindingDB Entry DOI: 10.7270/Q2N0151D |
More data for this
Ligand-Target Pair | |
D(1A) dopamine receptor
(Homo sapiens (Human)) | BDBM82505
(CAS_121881 | NSC_121881 | SB204070)Show InChI InChI=1S/C19H27ClN2O4/c1-2-3-6-22-7-4-13(5-8-22)12-26-19(23)14-11-15(20)16(21)18-17(14)24-9-10-25-18/h11,13H,2-10,12,21H2,1H3 | PDB
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| 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals
Curated by PDSP Ki Database
| |
Br J Pharmacol 112: 789-94 (1994)
Article DOI: 10.1111/j.1476-5381.1994.tb13148.x
BindingDB Entry DOI: 10.7270/Q2N0151D |
More data for this
Ligand-Target Pair | |
Adrenergic alpha2 receptor
(Mesocricetus auratus) | BDBM82505
(CAS_121881 | NSC_121881 | SB204070)Show InChI InChI=1S/C19H27ClN2O4/c1-2-3-6-22-7-4-13(5-8-22)12-26-19(23)14-11-15(20)16(21)18-17(14)24-9-10-25-18/h11,13H,2-10,12,21H2,1H3 | PDB
UniProtKB/TrEMBL
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| 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals
Curated by PDSP Ki Database
| |
Br J Pharmacol 112: 789-94 (1994)
Article DOI: 10.1111/j.1476-5381.1994.tb13148.x
BindingDB Entry DOI: 10.7270/Q2N0151D |
More data for this
Ligand-Target Pair | |
Beta-1 adrenergic receptor
(Homo sapiens (Human)) | BDBM82505
(CAS_121881 | NSC_121881 | SB204070)Show InChI InChI=1S/C19H27ClN2O4/c1-2-3-6-22-7-4-13(5-8-22)12-26-19(23)14-11-15(20)16(21)18-17(14)24-9-10-25-18/h11,13H,2-10,12,21H2,1H3 | PDB
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| 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals
Curated by PDSP Ki Database
| |
Br J Pharmacol 112: 789-94 (1994)
Article DOI: 10.1111/j.1476-5381.1994.tb13148.x
BindingDB Entry DOI: 10.7270/Q2N0151D |
More data for this
Ligand-Target Pair | |
D(3) dopamine receptor
(Homo sapiens (Human)) | BDBM82505
(CAS_121881 | NSC_121881 | SB204070)Show InChI InChI=1S/C19H27ClN2O4/c1-2-3-6-22-7-4-13(5-8-22)12-26-19(23)14-11-15(20)16(21)18-17(14)24-9-10-25-18/h11,13H,2-10,12,21H2,1H3 | PDB
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| 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals
Curated by PDSP Ki Database
| |
Br J Pharmacol 112: 789-94 (1994)
Article DOI: 10.1111/j.1476-5381.1994.tb13148.x
BindingDB Entry DOI: 10.7270/Q2N0151D |
More data for this
Ligand-Target Pair | |
Solute carrier family 22 member 1
(RAT) | BDBM82505
(CAS_121881 | NSC_121881 | SB204070)Show InChI InChI=1S/C19H27ClN2O4/c1-2-3-6-22-7-4-13(5-8-22)12-26-19(23)14-11-15(20)16(21)18-17(14)24-9-10-25-18/h11,13H,2-10,12,21H2,1H3 | UniProtKB/SwissProt
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| 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals
Curated by PDSP Ki Database
| |
Br J Pharmacol 112: 789-94 (1994)
Article DOI: 10.1111/j.1476-5381.1994.tb13148.x
BindingDB Entry DOI: 10.7270/Q2N0151D |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 2A
(Homo sapiens (Human)) | BDBM82505
(CAS_121881 | NSC_121881 | SB204070)Show InChI InChI=1S/C19H27ClN2O4/c1-2-3-6-22-7-4-13(5-8-22)12-26-19(23)14-11-15(20)16(21)18-17(14)24-9-10-25-18/h11,13H,2-10,12,21H2,1H3 | PDB
MMDB
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| 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals
Curated by PDSP Ki Database
| |
Br J Pharmacol 112: 789-94 (1994)
Article DOI: 10.1111/j.1476-5381.1994.tb13148.x
BindingDB Entry DOI: 10.7270/Q2N0151D |
More data for this
Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit alpha-1
(Homo sapiens (Human)) | BDBM82505
(CAS_121881 | NSC_121881 | SB204070)Show InChI InChI=1S/C19H27ClN2O4/c1-2-3-6-22-7-4-13(5-8-22)12-26-19(23)14-11-15(20)16(21)18-17(14)24-9-10-25-18/h11,13H,2-10,12,21H2,1H3 | PDB
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| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals
Curated by PDSP Ki Database
| |
Br J Pharmacol 112: 789-94 (1994)
Article DOI: 10.1111/j.1476-5381.1994.tb13148.x
BindingDB Entry DOI: 10.7270/Q2N0151D |
More data for this
Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit alpha-1
(Homo sapiens (Human)) | BDBM82505
(CAS_121881 | NSC_121881 | SB204070)Show InChI InChI=1S/C19H27ClN2O4/c1-2-3-6-22-7-4-13(5-8-22)12-26-19(23)14-11-15(20)16(21)18-17(14)24-9-10-25-18/h11,13H,2-10,12,21H2,1H3 | PDB
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| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals
Curated by PDSP Ki Database
| |
Br J Pharmacol 112: 789-94 (1994)
Article DOI: 10.1111/j.1476-5381.1994.tb13148.x
BindingDB Entry DOI: 10.7270/Q2N0151D |
More data for this
Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit alpha-1
(Rattus norvegicus (Rat)) | BDBM82505
(CAS_121881 | NSC_121881 | SB204070)Show InChI InChI=1S/C19H27ClN2O4/c1-2-3-6-22-7-4-13(5-8-22)12-26-19(23)14-11-15(20)16(21)18-17(14)24-9-10-25-18/h11,13H,2-10,12,21H2,1H3 | PDB
UniProtKB/SwissProt
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| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals
Curated by PDSP Ki Database
| |
Br J Pharmacol 112: 789-94 (1994)
Article DOI: 10.1111/j.1476-5381.1994.tb13148.x
BindingDB Entry DOI: 10.7270/Q2N0151D |
More data for this
Ligand-Target Pair | |
D(2) dopamine receptor
(Homo sapiens (Human)) | BDBM82505
(CAS_121881 | NSC_121881 | SB204070)Show InChI InChI=1S/C19H27ClN2O4/c1-2-3-6-22-7-4-13(5-8-22)12-26-19(23)14-11-15(20)16(21)18-17(14)24-9-10-25-18/h11,13H,2-10,12,21H2,1H3 | PDB
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| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals
Curated by PDSP Ki Database
| |
Br J Pharmacol 112: 789-94 (1994)
Article DOI: 10.1111/j.1476-5381.1994.tb13148.x
BindingDB Entry DOI: 10.7270/Q2N0151D |
More data for this
Ligand-Target Pair | |
Adenosine receptor A1
(Rattus norvegicus (rat)) | BDBM82505
(CAS_121881 | NSC_121881 | SB204070)Show InChI InChI=1S/C19H27ClN2O4/c1-2-3-6-22-7-4-13(5-8-22)12-26-19(23)14-11-15(20)16(21)18-17(14)24-9-10-25-18/h11,13H,2-10,12,21H2,1H3 | PDB
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| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals
Curated by PDSP Ki Database
| |
Br J Pharmacol 112: 789-94 (1994)
Article DOI: 10.1111/j.1476-5381.1994.tb13148.x
BindingDB Entry DOI: 10.7270/Q2N0151D |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 1D
(GUINEA PIG) | BDBM82505
(CAS_121881 | NSC_121881 | SB204070)Show InChI InChI=1S/C19H27ClN2O4/c1-2-3-6-22-7-4-13(5-8-22)12-26-19(23)14-11-15(20)16(21)18-17(14)24-9-10-25-18/h11,13H,2-10,12,21H2,1H3 | PDB
UniProtKB/SwissProt
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PC sid
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| Article
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| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals
Curated by PDSP Ki Database
| |
Br J Pharmacol 112: 789-94 (1994)
Article DOI: 10.1111/j.1476-5381.1994.tb13148.x
BindingDB Entry DOI: 10.7270/Q2N0151D |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 1E
(Homo sapiens (Human)) | BDBM82505
(CAS_121881 | NSC_121881 | SB204070)Show InChI InChI=1S/C19H27ClN2O4/c1-2-3-6-22-7-4-13(5-8-22)12-26-19(23)14-11-15(20)16(21)18-17(14)24-9-10-25-18/h11,13H,2-10,12,21H2,1H3 | PDB
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| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals
Curated by PDSP Ki Database
| |
Br J Pharmacol 112: 789-94 (1994)
Article DOI: 10.1111/j.1476-5381.1994.tb13148.x
BindingDB Entry DOI: 10.7270/Q2N0151D |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 4
(GUINEA PIG) | BDBM50421360
(CHEMBL358119 | SB-207058)Show InChI InChI=1S/C22H30N2O3/c1-2-3-11-23-13-9-17(10-14-23)16-27-22(25)20-18-7-4-5-8-19(18)24-12-6-15-26-21(20)24/h4-5,7-8,17H,2-3,6,9-16H2,1H3 | PDB
UniProtKB/SwissProt
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 0.0250 | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals
Curated by ChEMBL
| Assay Description
Ability to antagonize 5-HT-evoked contractions mediated through 5-hydroxytryptamine 4 receptor activation in the guinea pig distal colon LMMP |
J Med Chem 38: 4760-3 (1996)
BindingDB Entry DOI: 10.7270/Q2B56M1M |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 4
(GUINEA PIG) | BDBM82505
(CAS_121881 | NSC_121881 | SB204070)Show InChI InChI=1S/C19H27ClN2O4/c1-2-3-6-22-7-4-13(5-8-22)12-26-19(23)14-11-15(20)16(21)18-17(14)24-9-10-25-18/h11,13H,2-10,12,21H2,1H3 | PDB
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| n/a | n/a | 0.0800 | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals
Curated by ChEMBL
| Assay Description
Ability to antagonize 5-HT-evoked contractions mediated through 5-hydroxytryptamine 4 receptor activation in the guinea pig distal colon LMMP |
J Med Chem 38: 4760-3 (1996)
BindingDB Entry DOI: 10.7270/Q2B56M1M |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 4
(GUINEA PIG) | BDBM50421359
(CHEMBL145075)Show InChI InChI=1S/C21H28N2O3/c1-2-3-10-22-11-8-16(9-12-22)15-26-21(24)19-17-6-4-5-7-18(17)23-13-14-25-20(19)23/h4-7,16H,2-3,8-15H2,1H3 | PDB
UniProtKB/SwissProt
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| CHEMBL
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PC sid
UniChem
Similars
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| n/a | n/a | 0.100 | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals
Curated by ChEMBL
| Assay Description
Ability to antagonize 5-HT-evoked contractions mediated through 5-hydroxytryptamine 4 receptor activation in the guinea pig distal colon LMMP |
J Med Chem 38: 4760-3 (1996)
BindingDB Entry DOI: 10.7270/Q2B56M1M |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 4
(GUINEA PIG) | BDBM50422085
(CHEMBL142490)Show InChI InChI=1S/C20H28N2O3/c1-3-4-11-22-12-9-15(10-13-22)14-25-20(23)18-16-7-5-6-8-17(16)21-19(18)24-2/h5-8,15,21H,3-4,9-14H2,1-2H3 | PDB
UniProtKB/SwissProt
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| CHEMBL
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| n/a | n/a | 0.100 | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals
Curated by ChEMBL
| Assay Description
Ability to antagonize 5-HT-evoked contractions mediated through 5-hydroxytryptamine 4 receptor activation in the guinea pig distal colon LMMP |
J Med Chem 38: 4760-3 (1996)
BindingDB Entry DOI: 10.7270/Q2B56M1M |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 4
(GUINEA PIG) | BDBM82505
(CAS_121881 | NSC_121881 | SB204070)Show InChI InChI=1S/C19H27ClN2O4/c1-2-3-6-22-7-4-13(5-8-22)12-26-19(23)14-11-15(20)16(21)18-17(14)24-9-10-25-18/h11,13H,2-10,12,21H2,1H3 | PDB
UniProtKB/SwissProt
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| n/a | n/a | 0.100 | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of 5-HT-evoked 5-HT4 receptor-mediated contractions in the guinea pig distal colon longitudinal muscle myenteric plexus (LMMP) |
J Med Chem 36: 4121-3 (1994)
BindingDB Entry DOI: 10.7270/Q20003D7 |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 4
(GUINEA PIG) | BDBM50421362
(CHEMBL143862)Show InChI InChI=1S/C23H32N2O3/c1-2-3-12-24-14-10-18(11-15-24)17-28-23(26)21-19-8-4-5-9-20(19)25-13-6-7-16-27-22(21)25/h4-5,8-9,18H,2-3,6-7,10-17H2,1H3 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
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| n/a | n/a | 0.160 | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals
Curated by ChEMBL
| Assay Description
Ability to antagonize 5-HT-evoked contractions mediated through 5-hydroxytryptamine 4 receptor activation in the guinea pig distal colon LMMP |
J Med Chem 38: 4760-3 (1996)
BindingDB Entry DOI: 10.7270/Q2B56M1M |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 4
(GUINEA PIG) | BDBM50421361
(CHEMBL143426)Show InChI InChI=1S/C19H26N2O2/c1-2-3-10-21-11-8-15(9-12-21)14-23-19(22)17-13-20-18-7-5-4-6-16(17)18/h4-7,13,15,20H,2-3,8-12,14H2,1H3 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
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| n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals
Curated by ChEMBL
| Assay Description
Ability to antagonize 5-HT-evoked contractions mediated through 5-hydroxytryptamine 4 receptor activation in the guinea pig distal colon LMMP |
J Med Chem 38: 4760-3 (1996)
BindingDB Entry DOI: 10.7270/Q2B56M1M |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 4
(Homo sapiens (Human)) | BDBM85026
(N-(1-Butylpiperidine-4-ylmethyl)-1,2-(trimethylene...)Show InChI InChI=1S/C22H31N3O2/c1-2-3-11-24-13-9-17(10-14-24)16-23-21(26)20-18-7-4-5-8-19(18)25-12-6-15-27-22(20)25/h4-5,7-8,17H,2-3,6,9-16H2,1H3,(H,23,26) | PDB
UniProtKB/SwissProt
antibodypedia
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MCE
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| n/a | n/a | 0.630 | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals
Curated by ChEMBL
| Assay Description
Binding affinity was determined against 5-hydroxytryptamine 3 receptor |
J Med Chem 38: 4760-3 (1996)
BindingDB Entry DOI: 10.7270/Q2B56M1M |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 4
(GUINEA PIG) | BDBM50422007
(CHEMBL334818)Show InChI InChI=1S/C18H27ClN2O3/c1-3-4-7-21-8-5-13(6-9-21)12-24-18(22)14-10-15(19)16(20)11-17(14)23-2/h10-11,13H,3-9,12,20H2,1-2H3 | PDB
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UniChem
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| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of 5-HT-evoked 5-HT4 receptor-mediated contractions in the guinea pig distal colon longitudinal muscle myenteric plexus (LMMP) |
J Med Chem 36: 4121-3 (1994)
BindingDB Entry DOI: 10.7270/Q20003D7 |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 4
(GUINEA PIG) | BDBM50422009
(CHEMBL130040)Show InChI InChI=1S/C19H27NO4/c1-2-3-9-20-10-7-15(8-11-20)14-24-19(21)16-5-4-6-17-18(16)23-13-12-22-17/h4-6,15H,2-3,7-14H2,1H3 | PDB
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| n/a | n/a | 6.30 | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of 5-HT-evoked 5-HT4 receptor-mediated contractions in the guinea pig distal colon longitudinal muscle myenteric plexus (LMMP) |
J Med Chem 36: 4121-3 (1994)
BindingDB Entry DOI: 10.7270/Q20003D7 |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 4
(GUINEA PIG) | BDBM50422086
(CHEMBL142621)Show InChI InChI=1S/C23H33N3O2/c1-2-3-12-25-14-10-18(11-15-25)17-24-22(27)21-19-8-4-5-9-20(19)26-13-6-7-16-28-23(21)26/h4-5,8-9,18H,2-3,6-7,10-17H2,1H3,(H,24,27) | PDB
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| n/a | n/a | 7.90 | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals
Curated by ChEMBL
| Assay Description
Ability to antagonize 5-HT-evoked contractions mediated through 5-hydroxytryptamine 4 receptor activation in the guinea pig distal colon LMMP |
J Med Chem 38: 4760-3 (1996)
BindingDB Entry DOI: 10.7270/Q2B56M1M |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 4
(GUINEA PIG) | BDBM50422005
(CHEMBL130809)Show InChI InChI=1S/C18H28ClN3O2/c1-3-4-7-22-8-5-13(6-9-22)12-21-18(23)14-10-15(19)16(20)11-17(14)24-2/h10-11,13H,3-9,12,20H2,1-2H3,(H,21,23) | PDB
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| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of 5-HT-evoked 5-HT4 receptor-mediated contractions in the guinea pig distal colon longitudinal muscle myenteric plexus (LMMP) |
J Med Chem 36: 4121-3 (1994)
BindingDB Entry DOI: 10.7270/Q20003D7 |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 4
(GUINEA PIG) | BDBM50422083
(CHEMBL356546)Show InChI InChI=1S/C21H29N3O2/c1-2-3-10-23-11-8-16(9-12-23)15-22-20(25)19-17-6-4-5-7-18(17)24-13-14-26-21(19)24/h4-7,16H,2-3,8-15H2,1H3,(H,22,25) | PDB
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| n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals
Curated by ChEMBL
| Assay Description
Ability to antagonize 5-HT-evoked contractions mediated through 5-hydroxytryptamine 4 receptor activation in the guinea pig distal colon LMMP |
J Med Chem 38: 4760-3 (1996)
BindingDB Entry DOI: 10.7270/Q2B56M1M |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 4
(GUINEA PIG) | BDBM50422006
(CHEMBL130118)Show InChI InChI=1S/C20H29NO4/c1-2-3-10-21-11-8-16(9-12-21)15-25-20(22)17-6-4-7-18-19(17)24-14-5-13-23-18/h4,6-7,16H,2-3,5,8-15H2,1H3 | PDB
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| n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of 5-HT-evoked 5-HT4 receptor-mediated contractions in the guinea pig distal colon longitudinal muscle myenteric plexus (LMMP) |
J Med Chem 36: 4121-3 (1994)
BindingDB Entry DOI: 10.7270/Q20003D7 |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 4
(GUINEA PIG) | BDBM50422008
(CHEMBL132826)Show InChI InChI=1S/C18H25NO4/c1-2-3-9-19-10-7-14(8-11-19)12-21-18(20)15-5-4-6-16-17(15)23-13-22-16/h4-6,14H,2-3,7-13H2,1H3 | PDB
UniProtKB/SwissProt
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| PubMed
| n/a | n/a | 63 | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of 5-HT-evoked 5-HT4 receptor-mediated contractions in the guinea pig distal colon longitudinal muscle myenteric plexus (LMMP) |
J Med Chem 36: 4121-3 (1994)
BindingDB Entry DOI: 10.7270/Q20003D7 |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 4
(GUINEA PIG) | BDBM50422087
(CHEMBL422116)Show InChI InChI=1S/C20H29N3O2/c1-3-4-11-23-12-9-15(10-13-23)14-21-19(24)18-16-7-5-6-8-17(16)22-20(18)25-2/h5-8,15,22H,3-4,9-14H2,1-2H3,(H,21,24) | PDB
UniProtKB/SwissProt
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| n/a | n/a | 79 | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals
Curated by ChEMBL
| Assay Description
Ability to antagonize 5-HT-evoked contractions mediated through 5-hydroxytryptamine 4 receptor activation in the guinea pig distal colon LMMP |
J Med Chem 38: 4760-3 (1996)
BindingDB Entry DOI: 10.7270/Q2B56M1M |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 4
(GUINEA PIG) | BDBM50422084
(CHEMBL146386)Show InChI InChI=1S/C19H27N3O/c1-2-3-10-22-11-8-15(9-12-22)13-21-19(23)17-14-20-18-7-5-4-6-16(17)18/h4-7,14-15,20H,2-3,8-13H2,1H3,(H,21,23) | PDB
UniProtKB/SwissProt
GoogleScholar
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| CHEMBL
PC cid
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UniChem
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| n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals
Curated by ChEMBL
| Assay Description
Ability to antagonize 5-HT-evoked contractions mediated through 5-hydroxytryptamine 4 receptor activation in the guinea pig distal colon LMMP |
J Med Chem 38: 4760-3 (1996)
BindingDB Entry DOI: 10.7270/Q2B56M1M |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 4
(GUINEA PIG) | BDBM50056401
(2-diethylaminoethyl [2-methoxy-4-amino-5-chloro]be...)Show InChI InChI=1S/C14H21ClN2O3/c1-4-17(5-2)6-7-20-14(18)10-8-11(15)12(16)9-13(10)19-3/h8-9H,4-7,16H2,1-3H3 | PDB
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| n/a | n/a | 251 | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of 5-HT-evoked 5-HT4 receptor-mediated contractions in the guinea pig distal colon longitudinal muscle myenteric plexus (LMMP) |
J Med Chem 36: 4121-3 (1994)
BindingDB Entry DOI: 10.7270/Q20003D7 |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 4
(GUINEA PIG) | BDBM50108392
((3-ENDO)-8-METHYL-8-AZABICYCLO[3.2.1]OCT-3-YL 1H-I...)Show SMILES CN1[C@H]2CC[C@@H]1C[C@@H](C2)OC(=O)c1c[nH]c2ccccc12 |r,THB:9:7:4.3:1| Show InChI InChI=1S/C17H20N2O2/c1-19-11-6-7-12(19)9-13(8-11)21-17(20)15-10-18-16-5-3-2-4-14(15)16/h2-5,10-13,18H,6-9H2,1H3/t11-,12+,13+ | PDB
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| n/a | n/a | 3.16E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of 5-HT-evoked 5-HT4 receptor-mediated contractions in the guinea pig distal colon longitudinal muscle myenteric plexus (LMMP) |
J Med Chem 36: 4121-3 (1994)
BindingDB Entry DOI: 10.7270/Q20003D7 |
More data for this
Ligand-Target Pair | |
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